{"id":48439,"date":"2018-09-24T01:00:00","date_gmt":"2018-09-26T01:49:11","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e4%bb%8e%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9%e4%b8%ad%e6%9d%a5%ef%bc%8c%e5%88%b0nature%e5%b0%81%e9%9d%a2%e4%b8%8a%e5%8e%bb\/"},"modified":"2018-09-26T09:49:16","modified_gmt":"2018-09-26T01:49:16","slug":"%e4%bb%8e%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9%e4%b8%ad%e6%9d%a5%ef%bc%8c%e5%88%b0nature%e5%b0%81%e9%9d%a2%e4%b8%8a%e5%8e%bb","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/48439\/","title":{"rendered":"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;\"><span style=\"line-height: 0px;\">\u200d\u200d<\/span><span style=\"font-size: 18.018px;line-height: 0px;\">\u200d<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657590253&amp;idx=1&amp;sn=af64055348b35e9185b67c634d7ef95c&amp;chksm=80f7b23db7803b2bc868baa456f16ab2329ba355b97bce33703e32440ef4260a6f34c1ea970a&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-align: center;\"><\/a><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657590253&amp;idx=1&amp;sn=af64055348b35e9185b67c634d7ef95c&amp;chksm=80f7b23db7803b2bc868baa456f16ab2329ba355b97bce33703e32440ef4260a6f34c1ea970a&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-align: center;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;right: auto;bottom: auto;\"><img class=\"\"          style=\"height: 116px;width: 558px;top: auto;left: auto;right: auto;bottom: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537926552.jpeg\" alt=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\" title=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\"  \/><\/span><\/a><\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657574730&amp;idx=1&amp;sn=7001a26433acb77dcdd5629f27cd8b20&amp;chksm=80f7769ab780ff8cedab5baefd9bc7a02dd18b2191cd29afb2d190e8ea149564133c9437e7d5&amp;scene=21#wechat_redirect\" target=\"_blank\"><\/a><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 18px;\">Arylomycin<\/span><\/strong><span style=\"font-size: 18px;\">\u662f\u4e00\u7c7b\u5177\u6709\u6297\u83cc\u6d3b\u6027\u7684\u5927\u73af\u8102\u80bd\u7c7b\u5929\u7136\u4ea7\u7269\u3002\u8fd1\u65e5\uff0c<strong>\u4f18\u5316\u540e\u7684\u8fd9\u7c7b\u5929\u7136\u4ea7\u7269\u5206\u5b50<\/strong>\u4f5c\u4e3a\u65b0\u4e00\u7c7b\u6297\u751f\u7d20\u767b\u4e0a\u4e86<em><strong>Nature <\/strong><\/em>\u6742\u5fd7\u5c01\u9762\uff0c\u8be5\u6587\u4f5c\u8005\u4e3b\u8981\u6765\u81ea\u7f8e\u56fd\u5927\u540d\u9f0e\u9f0e\u7684<strong>\u57fa\u56e0\u6cf0\u514b\u516c\u53f8<\/strong>\uff08Genentech\uff09\u3002Arylomycin\u7684\u6297\u83cc\u6d3b\u6027\u65e9\u5df2\u88ab\u53d1\u73b0\uff0c<strong>Christopher Heise<\/strong>\u4e0e<strong>Peter Smith<\/strong>\u7b49\u4f5c\u8005\u5728\u64b0\u5199\u8fd9\u7bc7\u6587\u7ae0\u7684\u65f6\u5019\u5e76\u6ca1\u6709\u4ece\u5316\u5408\u7269\u672c\u8eab\u51fa\u53d1\uff0c\u800c\u662f\u4ece\u4e34\u5e8a\u4e9f\u987b\u89e3\u51b3\u7684\u591a\u91cd\u8010\u836f\uff08MDR\uff09\u7ec6\u83cc\u5165\u624b\u3002\u591a\u91cd\u8010\u836f\u7ec6\u83cc\u53c8\u79f0\u201c\u8d85\u7ea7\u7ec6\u83cc\u201d\uff0c\u80fd\u591f\u62b5\u6297\u4eba\u7c7b\u5df2\u7ecf\u62e5\u6709\u7684\u5927\u90e8\u5206\u6297\u751f\u7d20\uff0c\u53ef\u5f15\u8d77\u4e25\u91cd\u751a\u81f3\u81f4\u547d\u7684\u611f\u67d3\uff0c\u8ba9\u75c5\u4eba\u9762\u4e34\u65e0\u836f\u53ef\u7528\u7684\u7edd\u5883\u3002\u591a\u91cd\u8010\u836f\u7ec6\u83cc\u4e2d\u7684<strong>\u9769\u5170\u6c0f\u9634\u6027\u83cc<\/strong>\uff08Gram-negative bacteria\uff09\u5c24\u5176\u96be\u4ee5\u5bf9\u4ed8\uff0c\u5c3d\u7ba1\u65e0\u6570\u5927\u5c0f\u5236\u836f\u4f01\u4e1a\u52aa\u529b\u653b\u5173\uff0c\u6295\u5165\u4e86\u65e0\u6570\u7684\u8d44\u91d1\u548c\u4eba\u529b\uff0c\u4f46\u5728\u8fc7\u53bb50\u5e74\u91cc\uff0c\u8fd8\u6ca1\u6709\u4efb\u4f55\u4e00\u7c7b\u9488\u5bf9\u9769\u5170\u6c0f\u9634\u6027\u83cc\u7684\u65b0\u578b\u6297\u751f\u7d20\u83b7\u6279\u4e0a\u5e02\uff0c\u96be\u5ea6\u53ef\u89c1\u4e00\u6591\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1537926552.jpeg\" alt=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\" title=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1a<em>Nature<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u54b1\u4eec\u9996\u5148\u5f97\u505a\u4e00\u4e2a\u7b80\u5355\u79d1\u666e\u3002\u9769\u5170\u6c0f\u9633\u6027\u83cc\uff08Gram-positive bacteria\uff09\u548c\u9769\u5170\u6c0f\u9634\u6027\u83cc\u662f\u6307\u5bf9\u9769\u5170\u6c0f\u67d3\u8272\u53cd\u5e94\u5206\u522b\u4ea7\u751f\u9633\u6027\u548c\u9634\u6027\u7ed3\u679c\u7684\u7ec6\u83cc\uff0c\u5b83\u4eec\u7684\u7ec6\u80de\u58c1\u5177\u6709\u4e0d\u540c\u7684\u7ed3\u6784\uff08\u4e0b\u56fe\uff09\u3002\u9769\u5170\u6c0f\u9634\u6027\u83cc\u5177\u6709\u4e24\u5c42\u819c\u7ed3\u6784\uff0c\u4e3a\u5176\u6784\u6210\u4e86\u4e25\u5bc6\u9632\u62a4\uff0c\u7279\u522b\u5f53\u8fd9\u4e9b\u7ec6\u83cc\u51fa\u73b0\u4e86\u591a\u836f\u8010\u836f\u7a81\u53d8\u4e4b\u540e\uff0c\u95ee\u9898\u5c31\u53d8\u5f97\u66f4\u52a0\u68d8\u624b\uff0c\u4eba\u7c7b\u5f80\u5f80\u675f\u624b\u65e0\u7b56\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537926553.jpeg\" alt=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\" title=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u81ea\u7f51\u7edc<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u57fa\u56e0\u6cf0\u514b\u7684\u79d1\u7814\u56e2\u961f\u9488\u5bf9\u8fd9\u4e00\u4e16\u754c\u6027\u96be\u9898\u53d1\u8d77\u6311\u6218\u3002\u4ed6\u4eec\u4ee5\u5177\u6709\u6297\u83cc\u6d3b\u6027\u7684\u5929\u7136\u4ea7\u7269arylomycin\u4e3a\u5148\u5bfc\u5316\u5408\u7269\u8fdb\u884c\u4e86\u7ed3\u6784\u4f18\u5316\uff0c\u5f97\u5230\u4e86\u53ef\u6709\u6548\u6740\u6b7b\u9769\u5170\u6c0f\u9634\u6027\u83cc\u5e76\u4e14\u8f83arylomycin\u5bf9\u8010\u836f\u83cc\u682a\u6d3b\u6027\u63d0\u9ad8500\u500d\u7684\u5206\u5b50G0775\u3002\u672c\u541b\u4eca\u5929\u5c31\u4ece\u8be5\u6587\u7ae0\u7684\u5b66\u672f\u5185\u5bb9\u89d2\u5ea6\u7b80\u5355\u5206\u6790\u4e00\u4e0b\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">Arylomycin\u7684\u6297\u83cc\u6d3b\u6027\u662f\u57fa\u4e8e\u5bf9\u4fe1\u53f7\u80bd\u9176\uff08SPase\uff09\u7684\u6291\u5236\u4f5c\u7528\uff0c\u8fd9\u662f\u524d\u4eba\u7814\u7a76\u7684\u7ed3\u679c\u3002\u4f46\u662f\uff0c\u5728\u9769\u5170\u6c0f\u9634\u6027\u83cc\u4e2d\u8fd9\u4e2a\u9176\u4f4d\u4e8e\u53cc\u5c42\u819c\u7ed3\u6784\u4e2d\u95f4\u548c\u5185\u819c\u90e8\u5206\uff0c\u8fd9\u5c31\u4f7f\u5f97arylomycin\u5bf9\u9769\u5170\u6c0f\u9634\u6027\u83cc\u7684\u6d3b\u6027\u5927\u4e3a\u964d\u4f4e\u3002<strong>\u90a3\u4e3a\u4ec0\u4e48\u57fa\u56e0\u6cf0\u514b\u7684\u79d1\u7814\u56e2\u961f\u575a\u6301\u5f00\u53d1\u8fd9\u4e2a\u5316\u5408\u7269\u800c\u4e0d\u662f\u53e6\u8d77\u7089\u7076\u5462\uff1f<\/strong>\u6211\u60f3\u8fd9\u662f\u8bb8\u591a\u540c\u5b66\u5173\u5fc3\u7684\u5b66\u672f\u95ee\u9898\u3002\u91cd\u70b9\u6765\u5566\uff0c\u4ed6\u4eec\u4ece\u65c1\u4eba\u7684\u7814\u7a76\u4e2d\u5f97\u5230\u4e86\u542f\u793a\uff0carylomycin\u5bf9\u4e8e\u7a81\u53d8\u7684\u9769\u5170\u6c0f\u9634\u6027\u83cc\u4fe1\u53f7\u80bd\u9176LepB\u7684\u7ed3\u5408\u529b\u663e\u8457\u4e0b\u964d\u3002\u8fd9\u5c31\u8bf4\u660e\uff0carylomycin\u8fd9\u4e2a\u5316\u5408\u7269\u80fd\u900f\u8fc7\u53cc\u5c42\u819c\u7ed3\u6784\u7684\u5916\u819c\uff0c\u5230\u8fbe\u4fe1\u53f7\u80bd\u9176\u9776\u70b9\uff01\u65e2\u7136\u80fd\u8fc7\u5916\u819c\u3001\u5230\u9776\u70b9\uff0c\u90a3\u4e48\u63d0\u9ad8\u5316\u5408\u7269\u548c\u9776\u70b9\u7ed3\u5408\u529b\u5c31\u662f\u4e86\u3002\u8fd9\u79cd\u4e8b\u5bf9\u836f\u7269\u5316\u5b66\u5de5\u4f5c\u8005\u6765\u8bf4\u7b80\u76f4\u662f\u5bb6\u5e38\u4fbf\u996d\u5566\uff0c\u7279\u522b\u662f\u76ee\u6807\u9776\u70b9\u8fd8\u6709\u6676\u4f53\u7ed3\u6784\uff0c\u90a3\u5b8c\u5168\u53ef\u4ee5\u7528\u4e0a\u6559\u79d1\u4e66\u91cc\u7684\u5404\u79cd\u836f\u7269\u8bbe\u8ba1\u624b\u6bb5\u5b9e\u73b0\u201c\u7cbe\u51c6\u6253\u51fb\u201d\uff0c\u5408\u7406\u836f\u7269\u8bbe\u8ba1\u3002\u5177\u4f53\u7684\u4f18\u5316\u7b56\u7565\u5e76\u4e0d\u96be\uff0c\u4fdd\u7559arylomycin\u4e0e\u9776\u70b9\u7ed3\u5408\u7684\u5927\u73af\u80bd\u7c7b\u7ed3\u6784\uff0c\u4f18\u5316\u539f\u6709\u7684\u8102\u80aa\u80bd\u94fe\u4ee5\u63d0\u9ad8\u6d3b\u6027\uff0c\u8fdb\u4e00\u6b65\u5f15\u5165\u4eb2\u7535\u53cd\u5e94\u201c\u5f39\u5934\u201d\u6c30\u57fa\u9170\u80fa\u7528\u4e8e\u548c\u9776\u70b9\u751f\u6210\u5171\u4ef7\u952e\uff0c\u6700\u540e\u6839\u636e\u6587\u732e\u62a5\u9053\u4fee\u9970\u4e24\u4e2a\u915a\u7f9f\u57fa\uff0c\u6700\u7ec8\u5f97\u5230\u4e86\u6d3b\u6027\u63d0\u9ad8\u7684\u65b0\u5206\u5b50G0775\u3002\u5177\u4f53\u5316\u5408\u7269\u7ed3\u6784\u5982\u4e0b\u56fe\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537926553.jpeg\" alt=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\" title=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1a<em>Nature<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u7ed3\u6784\u4f18\u5316\u5f97\u5230\u7684G0775\u5bf9\u591a\u79cd\u9769\u5170\u6c0f\u9634\u6027\u83cc\u7684\u6291\u83cc\u6d3b\u6027\u8fd8\u662f\u975e\u5e38\u7a81\u51fa\u7684\uff0c\u5168\u9762\u8d85\u8d8a\u539f\u6765\u7684arylomycin\uff08Table 1\uff09\u3002\u540c\u65f6\uff0cG0775\u5bf9\u8010\u836f\u83cc\u682a\u7684\u4f5c\u7528\u66f4\u662f\u975e\u5e38\u4e86\u5f97\uff08Table 2\uff09\u3002\u8fd9\u5f88\u53ef\u80fd\u89e3\u51b3\u6297\u751f\u7d20\u7814\u53d1\u9886\u57df\u7684\u4e00\u5927\u91cd\u8981\u6280\u672f\u96be\u9898\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1537926553.jpeg\" alt=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\" title=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\"  \/><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537926554.jpeg\" alt=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\" title=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\"  \/><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537926554.jpeg\" alt=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\" title=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1a<em>Nature<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u8bb2\u5b8c\u4e86\u836f\u7269\u5bf9\u7ec6\u80de\u8868\u578b\u53d8\u5316\u5f71\u54cd\uff08\u6291\u83cc\uff09\uff0c\u5c31\u8be5\u804a\u804a\u673a\u5236\u4e86\u3002\u8fd9\u4e2a\u5957\u8def\u5728<em>Nature <\/em>\u7684\u6587\u7ae0\u4e2d\u4e5f\u4e0d\u4f8b\u5916\u3002\u4f5c\u8005\u4e3b\u8981\u4ece\u4e24\u4e2a\u5c42\u9762\u8bb2\u4e86G0775\u5168\u65b0\u7684\u4f5c\u7528\u673a\u5236\u3002\u5176\u4e00\u662f\u5316\u5408\u7269\u548c\u9776\u70b9\u7684\u4f5c\u7528\u5f62\u5f0f\uff1b\u5176\u4e8c\u662f\u9610\u8ff0\u4e86G0775\u5982\u4f55\u5230\u8fbe\u9776\u70b9\u3002\u54b1\u4eec\u5148\u8bf4\u7b2c\u4e00\u70b9\uff0c\u65e2\u7136\u5316\u5408\u7269\u8bbe\u8ba1\u6765\u81ea\u86cb\u767d\u6676\u4f53\u7ed3\u6784\uff0c\u90a3\u4e48G0775\u4e0e\u9776\u70b9\u7684\u5171\u6676\u7ed3\u6784\u81ea\u7136\u5907\u53d7\u671f\u5f85\u3002<strong>\u7b11\u70b9\u6765\u5566\uff0c\u4f5c\u8005\u539f\u6587\u660e\u786e\u5199\u5230\uff0c\u5f53\u521d\u8bbe\u8ba1\u5316\u5408\u7269\u7684\u65f6\u5019\u4eb2\u7535\u201c\u5f39\u5934\u201d\u7ed3\u6784\u7684\u5f15\u5165\u662f\u4e3a\u4e86\u548c\u9776\u70b9\u4e2d\u7684\u4e1d\u6c28\u917891\uff08S91\uff09\u5f62\u6210\u5171\u4ef7\u952e\u4ee5\u589e\u5f3a\u7ed3\u5408\u529b\u3002\u7ed3\u679c\uff0c\u6700\u540e\u7684\u5171\u6676\u7ed3\u679c\u544a\u8bc9\u6211\u4eec\uff0cG0775\u4e0e\u8d56\u6c28\u9178\uff08K146\uff09\u5f62\u6210\u4e86\u5171\u4ef7\u952e\uff0c\u6ca1\u6709S91\u4ec0\u4e48\u4e8b<\/strong>\u3002\u4e3a\u4e86\u66f4\u76f4\u63a5\u7684\u9a8c\u8bc1\u8fd9\u4e2a\u4e8b\u5b9e\uff0c\u4ed6\u4eec\u505a\u4e86G0775\u4e0e\u9776\u70b9\u6df7\u5408\u540e\u7684\u8d28\u8c31\u3002\u7ed3\u679c\u4f9d\u65e7\u201c\u6253\u8138\u201d\uff0c\u7ed3\u5408\u4f4d\u70b9\u7684\u786e\u5728LDYIKR\u80bd\u6bb5\u7684\u8d56\u6c28\u9178\u3002\u201c\u6b6a\u6253\u6b63\u7740\u201d\u4e5f\u597d\uff0c\u201c\u5e78\u8fd0\u5149\u73af\u52a0\u8eab\u201d\u4e5f\u597d\uff0cG0775\u4e0e\u9776\u70b9\u7684\u7ed3\u5408\u7684\u786e\u5f88\u5f3a\uff0c\u9176\u52a8\u529b\u5b66\u7ed3\u679c\u4ece\u5177\u4f53\u6570\u636e\u5c42\u9762\u8bc1\u5b9e\u4e86\u8fd9\u4e00\u70b9\uff08KI = 0.44 nM\uff09\u3002\u6240\u4ee5\uff0c\u5404\u4f4d\u540c\u5b66\u5982\u679c\u4f60\u4eec\u8981\u60f3\u8bc1\u660e\u81ea\u5df1\u7684\u5316\u5408\u7269\u548c\u67d0\u4e2a\u9776\u70b9\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u53ef\u4ee5\u4ece\u4e0a\u8ff0\u4e09\u4e2a\u7ef4\u5ea6\u9610\u8ff0\u95ee\u9898\uff0c\u6bd5\u7adf\u8fd9\u662f<em>Nature <\/em>\u6807\u51c6\u54e6\u3002\u81f3\u4e8e\u53e6\u4e00\u4e2a\u4f5c\u7528\u673a\u5236\u561b\uff0c\u4f5c\u8005\u5408\u6210\u4e86\u4e00\u4e9b\u5e26\u7535\u8377\u7684\u884d\u751f\u7269\uff0c\u53c8\u5229\u7528\u7a81\u53d8\u83cc\u682a\u8bc1\u660e\u4e86G0775\u5e76\u4e0d\u662f\u4ece\u6781\u6027\u7269\u8d28\u5e38\u89c4\u7684\u901a\u9053\u86cb\u767d\uff08porin\uff09\u900f\u8fc7\u5916\u819c\u7684\u3002\u8fd9\u7b97\u4e0d\u4e0a\u4ec0\u4e48\u7279\u522b\u7684\u673a\u5236\uff0c\u4f5c\u8005\u4e5f\u5c31\u6ca1\u628a\u5b9e\u9a8c\u7ed3\u679c\u653e\u5728\u6b63\u6587\u90e8\u5206\u3002\u4e00\u53e5\u8bdd\uff0cG0775\u4e0d\u8d70\u5bfb\u5e38\u8def\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537926554.jpeg\" alt=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\" title=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1a<em>Nature<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u6587\u7ae0\u6700\u540e\uff0c\u4f5c\u8005\u7ed9\u51fa\u4e86\u4e00\u4e9b\u52a8\u7269\u5b9e\u9a8c\u7ed3\u679c\uff0c\u5f53\u7136\u8fd9\u4e5f\u662f\u6807\u51c6\u5957\u8def\u5566\u3002\u5728\u591a\u79cd\u52a8\u7269\u6a21\u578b\u4e0a\u8bc4\u4ef7\u4e86G0775\u5bf9\u5305\u62ec\u591a\u91cd\u8010\u836f\u83cc\u5728\u5185\u7684\u591a\u79cd\u9769\u5170\u6c0f\u9634\u6027\u7ec6\u83cc\u611f\u67d3\u7684\u6cbb\u7597\u4f5c\u7528\u3002\u5b9e\u9a8c\u7ed3\u679c\u54b1\u5c31\u4e0d\u8d58\u8ff0\u4e86\u5427\uff0c\u80fd\u4e0a<em>Nature<\/em>\u5c01\u9762\u7684\u6587\u7ae0\u7ed3\u679c\u81ea\u7136\u5dee\u4e0d\u4e86\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537926555.jpeg\" alt=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\" title=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1a<em>Nature<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u7167\u4f8b\uff0c\u672c\u541b\u8fd8\u662f\u5728\u6700\u540e\u6597\u80c6\u70b9\u8bc4\u51e0\u53e5\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u79c1\u4ee5\u4e3a\uff0c\u8fd9\u7bc7\u6587\u7ae0\u6700\u5927\u7684\u4eae\u70b9\u5c31\u662f\u5bf9\u9769\u5170\u6c0f\u9634\u6027\u83cc\u6740\u706d\u7684\u5168\u65b0\u673a\u5236\u3002\u81f3\u4e8e\u836f\u7269\u5316\u5b66\u90e8\u5206\uff0c\u4f5c\u8005\u5e76\u6ca1\u6709\u8be6\u8ff0\u4f18\u5316\u8fc7\u7a0b\u3002\u5728\u672c\u541b\u770b\u6765\u4e5f\u5e76\u6ca1\u6709\u592a\u591a\u7684\u65b0\u610f\uff0c\u8102\u80aa\u94fe\u7684\u66ff\u6362\u5e38\u89c1\u4e8e\u5404\u7c7b\u8102\u8d28\u6a21\u62df\u7269\u836f\u7269\uff0c\u770b\u4f3c\u7cbe\u51c6\u7684\u57fa\u4e8e\u6676\u4f53\u7ed3\u6784\u7684\u5408\u7406\u836f\u7269\u8bbe\u8ba1\uff0c\u5728\u8fd9\u4e2a\u4f8b\u5b50\u4e0a\u66f4\u662f\u5e26\u4e86\u51e0\u5206\u5e7d\u9ed8\u611f\u3002\u82e5\u662f\u4ece\u836f\u7269\u5f00\u53d1\u7684\u89d2\u5ea6\u6765\u8bb2\uff0c\u5171\u4ef7\u7ed3\u5408\u836f\u7269\u6c38\u8fdc\u7ed5\u4e0d\u5f00\u7cfb\u7edf\u7684\u6bd2\u6027\u98ce\u9669\u3002\u5f53\u7136\uff0c\u8fd9\u4e48\u5927\u7684\u73af\u518d\u52a0\u4e0a\u4e24\u4e2a\u82b3\u73af\uff0cG0775\u7684\u836f\u4ee3\u884c\u4e3a\u53c8\u4f1a\u662f\u600e\u6837\u5462\uff1f\u53cd\u6b63\u6ca1\u6709\u836f\u4ee3\u6570\u636e\u548c\u6bd2\u6027\u6570\u636e\u5df2\u7ecf\u53d1\u5230\u9876\u520a\u5c01\u9762\u4e86\uff0c\u4e0d\u77e5\u9053\u662f\u57fa\u56e0\u6cf0\u514b\u6545\u610f\u96ea\u85cf\u5173\u952e\u6570\u636e\u4e3a\u5176\u65b0\u836f\u505a\u51c6\u5907\uff0c\u8fd8\u662f\u50cf\u672c\u541b\u62c5\u5fc3\u7684\u90a3\u6837\uff1a\u98ce\u9669\u5747\u5df2\u5151\u73b0\uff0c\u5fcd\u75db\u6bd9\u9879\u76ee\u53d1\u8bba\u6587\u8fdb\u884c\u201c\u5e9f\u7269\u5229\u7528\u201d\u5462\uff1f\u5927\u4f19\u62ed\u76ee\u4ee5\u5f85\u5427\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762\uff09\uff1a<\/span><\/p>\n<p><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537926555.jpeg\" alt=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\" title=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">Optimized arylomycins are a new class of Gram-negative antibiotics<\/span><\/p>\n<p><em><span style=\"font-size: 14px;\">Nature<\/span><\/em><span style=\"font-size: 14px;\">, <strong>2018<\/strong>, <em>561<\/em>, 189-194, DOI: 10.1038\/s41586-018-0483-6<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: right;\">\uff08\u672c\u6587\u7531<strong>\u4e50\u53ea\u541b\u5b50<\/strong>\u4f9b\u7a3f\uff09<\/p>\n<p><br  \/><\/p>\n<section style=\"white-space: normal;\">\n<section class=\"Powered-by-XIUMI V5\" >\n<section class=\"\">\n<section class=\"\">\n<p style=\"text-align: center;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657590253&amp;idx=1&amp;sn=af64055348b35e9185b67c634d7ef95c&amp;chksm=80f7b23db7803b2bc868baa456f16ab2329ba355b97bce33703e32440ef4260a6f34c1ea970a&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"font-size: 18.018px;\"><\/a><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657590253&amp;idx=1&amp;sn=af64055348b35e9185b67c634d7ef95c&amp;chksm=80f7b23db7803b2bc868baa456f16ab2329ba355b97bce33703e32440ef4260a6f34c1ea970a&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"font-size: 18.018px;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;right: auto;bottom: auto;\"><img class=\"\"          style=\"height: 116px;width: 558px;top: auto;left: auto;right: auto;bottom: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537926555.jpeg\" alt=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\" title=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\"  \/><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 25.6px;text-align: center;\"><img      style=\"font-size: 18px;background-color: rgb(255, 255, 255);line-height: 25.6px;width: 556px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537926555.png\" alt=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\" title=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\"  \/><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section class=\"\" style=\"height: 16px;box-sizing: border-box;\">\n<section style=\"height: 15.9961px;width: 24px;float: left;border-top: 6px solid rgb(9, 158, 206);border-left: 6px solid rgb(9, 158, 206);border-right-color: rgb(9, 158, 206);border-bottom-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"height: 15.9961px;width: 24px;float: right;border-top: 6px solid rgb(9, 158, 206);border-right: 6px solid rgb(9, 158, 206);border-bottom-color: rgb(9, 158, 206);border-left-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;color: transparent;clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<section class=\"\" style=\"margin: -13px 3px;padding: 12px;border-width: 1px;border-style: solid;border-color: rgb(9, 158, 206);border-radius: 6px;word-wrap: break-word;box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 18px;\">\u672c\u6587\u7248\u6743\u5c5e\u4e8e<span style=\"color: rgb(9, 158, 206);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">X-MOL<\/strong><\/span>\uff08x-mol.com\uff09\uff0c\u672a\u7ecf\u8bb8\u53ef\u8c22\u7edd\u8f6c\u8f7d\uff01\u6b22\u8fce\u8bfb\u8005\u670b\u53cb\u4eec\u5206\u4eab\u5230\u670b\u53cb\u5708or\u5fae\u535a\uff01<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 18px;\"><span style=\"color: rgb(9, 158, 206);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u957f\u6309<\/strong><\/span>\u4e0b\u56fe<strong style=\"box-sizing: border-box;\">\u8bc6\u522b\u56fe\u4e2d\u4e8c\u7ef4\u7801<\/strong>\uff0c\u8f7b\u677e\u5173\u6ce8\u6211\u4eec\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<p style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\"><img class=\"\"     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537926556.jpeg\" alt=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\" title=\"\u4ece\u5929\u7136\u4ea7\u7269\u4e2d\u6765\uff0c\u5230Nature\u5c01\u9762\u4e0a\u53bb\"  \/><\/p>\n<\/section>\n<\/section>\n<section class=\"\" style=\"height: 16px;box-sizing: border-box;\">\n<section style=\"height: 15.9961px;width: 24px;float: left;border-bottom: 6px solid rgb(9, 158, 206);border-left: 6px solid rgb(9, 158, 206);border-top-color: rgb(9, 158, 206);border-right-color: rgb(9, 158, 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