{"id":48840,"date":"2018-09-19T01:00:00","date_gmt":"2018-09-26T01:52:32","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e3%80%90%e5%88%86%e6%9e%90%e3%80%91%e5%9f%ba%e5%9b%a0%e7%bc%96%e7%a0%81%e7%9a%84rna%e5%8f%91%e5%a4%b9%e7%bb%93%e6%9e%84%e7%94%a8%e4%bd%9c%e6%b4%bb%e7%bb%86%e8%83%9e%e5%86%85rna%e7%9a%84%e7%81%b5\/"},"modified":"2018-09-26T09:52:34","modified_gmt":"2018-09-26T01:52:34","slug":"%e3%80%90%e5%88%86%e6%9e%90%e3%80%91%e5%9f%ba%e5%9b%a0%e7%bc%96%e7%a0%81%e7%9a%84rna%e5%8f%91%e5%a4%b9%e7%bb%93%e6%9e%84%e7%94%a8%e4%bd%9c%e6%b4%bb%e7%bb%86%e8%83%9e%e5%86%85rna%e7%9a%84%e7%81%b5","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/48840\/","title":{"rendered":"\u3010\u5206\u6790\u3011\u57fa\u56e0\u7f16\u7801\u7684RNA\u53d1\u5939\u7ed3\u6784\u7528\u4f5c\u6d3b\u7ec6\u80de\u5185RNA\u7684\u7075\u654f\u6210\u50cf"},"content":{"rendered":"
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\u200d\u200d<\/span>\u200d<\/a>\"\u3010\u5206\u6790\u3011\u57fa\u56e0\u7f16\u7801\u7684RNA\u53d1\u5939\u7ed3\u6784\u7528\u4f5c\u6d3b\u7ec6\u80de\u5185RNA\u7684\u7075\u654f\u6210\u50cf\"<\/span><\/a><\/span><\/a><\/p>\n


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DNA\u548cRNA\u53ef\u6298\u53e0\u6210\u7cbe\u786e\u7eb3\u7c73\u7ed3\u6784\uff0c\u5df2\u7ecf\u88ab\u5e7f\u6cdb\u8fd0\u7528\u5230\u751f\u7269\u5b66\u548c\u751f\u7269\u533b\u5b66\u7684\u9886\u57df\u4e2d\uff0c\u8fd9\u4e9b\u6838\u9178\u7cbe\u786e\u81ea\u7ec4\u88c5\u7684\u7eb3\u7c73\u7ed3\u6784\u4e5f\u4e3a\u53ef\u7f16\u7a0b\u7684\u5206\u5b50\u8bc6\u522b\u63d0\u4f9b\u4e86\u4e00\u79cd\u5f3a\u6709\u529b\u7684\u5de5\u5177\u3002\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u4e2d\uff0c\u4e00\u7cfb\u5217\u590d\u6742\u7684\u6838\u9178\u7535\u8def\u5df2\u7ecf\u88ab\u8bbe\u8ba1\u5e76\u5e94\u7528\u4e8e\u751f\u7269\u5206\u6790\u9886\u57df\uff0c\u5176\u4e2d\uff0c\u50ac\u5316\u53d1\u5939\u7ec4\u88c5\uff08CHA\uff09\u88ab\u8bc1\u660e\u5177\u6709\u4fe1\u53f7\u653e\u5927\u6548\u7387\u9ad8\u3001\u80cc\u666f\u4f4e\u3001\u54cd\u5e94\u901f\u5ea6\u5feb\u7b49\u4f18\u70b9\u3002\u57fa\u4e8e\u9ad8\u5ea6\u7075\u654f\u548c\u9776\u5411\u7279\u5f02\u7684CHA\u53cd\u5e94\u8bbe\u8ba1\u7684DNA\u7535\u8def\u5df2\u7ecf\u88ab\u5e94\u7528\u4e8e\u5404\u79cd\u4f53\u5916\u68c0\u6d4b\uff0c\u5176\u4e2d\u5305\u62ec\u5404\u79cd\u6838\u9178\u3001\u86cb\u767d\u8d28\u548c\u5c0f\u5206\u5b50\u7684\u5b9a\u91cf\u5206\u6790\u3002\u4e0d\u8fc7\u82e5\u8981\u4f7f\u7528\u8fd9\u4e9bDNA\u7535\u8def\u53bb\u8fdb\u884c\u7ec6\u80de\u5185\u68c0\u6d4b\u6216\u57fa\u56e0\u8c03\u63a7\uff0c\u4f1a\u9762\u4e34DNA\u5206\u5b50\u7684\u751f\u7269\u9012\u9001\u6548\u7387\u4f4e\u548c\u7ec6\u80de\u5185\u6613\u964d\u89e3\u7b49\u95ee\u9898\u3002\u540c\u6837\u4f5c\u4e3a\u6838\u9178\u7684RNA\u5206\u5b50\u5374\u53ef\u4ee5\u5728\u7ec6\u80de\u5185\u901a\u8fc7\u57fa\u56e0\u7f16\u7801\u8fdb\u884c\u8f6c\u5f55\u751f\u6210\u3002\u56e0\u6b64\uff0c\u57fa\u4e8eRNA\u5206\u5b50\u8bbe\u8ba1\u7684CHA\u7535\u8def\u5728\u7ec6\u80de\u5185\u751f\u7269\u68c0\u6d4b\u9886\u57df\u5177\u6709\u5341\u5206\u5de8\u5927\u7684\u6f5c\u529b\u3002<\/span><\/p>\n


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\u8fd1\u65e5\uff0c\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5927\u5b66<\/strong>\u7684\u5c24\u660e\u65ed<\/strong>\u56e2\u961f\u62a5\u9053\u4e86\u4e00\u79cd\u57fa\u4e8e\u9057\u4f20\u7f16\u7801RNA\u5206\u5b50\u8bbe\u8ba1\u7684CHA\u7535\u8def\u7528\u4f5c\u6d3b\u7ec6\u80de\u5185RNA\u7684\u7075\u654f\u6210\u50cf<\/strong>\u3002\u901a\u8fc7\u57fa\u56e0\u7f16\u7801\u6280\u672f\uff0c\u7ec6\u80de\u53ef\u4ee5\u81ea\u52a8\u8f6c\u5f55\u751f\u6210RNA\u53d1\u5939H1\u548cH2\u3002\u5176\u4e2d\uff0cBroccoli RNA\u9002\u4f53\u88ab\u5206\u88c2\u6210\u4e24\u90e8\u5206\uff0c\u5206\u522b\u8fde\u63a5\u5728H1\u548cH2\u4e0a\u3002\u5f53\u6709\u76ee\u6807RNA\u5206\u5b50\u5b58\u5728\u65f6\uff0c\u4e00\u4e2a\u76ee\u6807RNA\u5206\u5b50\u53ef\u4ee5\u50ac\u5316\u89e6\u53d1\u591a\u4e2aH1\u548cH2\u7ec4\u88c5\uff0c\u751f\u6210\u6570\u4e2aBroccoli\u9002\u4f53\uff0c\u7ed3\u5408\u5c0f\u5206\u5b50DFHBI-1T\u540e\u4ea7\u751f\u8367\u5149\u4fe1\u53f7\u3002\uff0c\u4ece\u800c\u901a\u8fc7\u4fe1\u53f7\u653e\u5927\u7075\u654f\u5730\u68c0\u6d4b\u4f4e\u6d53\u5ea6\u7684\u76ee\u6807RNA\u3002\u8fd9\u4e2a\u57fa\u4e8e\u9057\u4f20\u7f16\u7801RNA\u5206\u5b50\u8bbe\u8ba1\u7684CHA\u7535\u8def\u88ab\u547d\u540d\u4e3aCHARGE\uff0c\u5e76\u88ab\u6210\u529f\u5e94\u7528\u4e8e\u7ec6\u83cc\u5185\u7684\u4f4e\u6d53\u5ea6RNA\u5206\u5b50\u6210\u50cf\u3002\u5b9e\u9a8c\u6570\u636e\u663e\u793a\uff0c\u5728\u5355\u4e2a\u7ec6\u80de\u4e2d\uff0c\u4f4e\u81f3\u53ea\u6709110\u4e2a\u62f7\u8d1d\u526f\u672c\u7684\u76ee\u6807RNA\u5206\u5b50\u53ef\u572830\u5206\u949f\u5185\u88ab\u6210\u529f\u68c0\u6d4b\u5230\uff0c\u8bc1\u660e\u4e86\u6b64\u8bbe\u8ba1\u7684\u786e\u53ef\u4ee5\u5bf9\u7ec6\u80de\u5185\u4f4e\u6d53\u5ea6RNA\u5206\u5b50\u8fdb\u884c\u9ad8\u6548\u7075\u654f\u5730\u68c0\u6d4b\u3002<\/span><\/p>\n

\"\u3010\u5206\u6790\u3011\u57fa\u56e0\u7f16\u7801\u7684RNA\u53d1\u5939\u7ed3\u6784\u7528\u4f5c\u6d3b\u7ec6\u80de\u5185RNA\u7684\u7075\u654f\u6210\u50cf\"<\/p>\n


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\u4e0e\u6b64\u540c\u65f6\uff0cCHARGE\u7684\u8bbe\u8ba1\u4e5f\u5177\u6709\u5728\u771f\u6838\u7ec6\u80de\u4e2d\u8fdb\u884cRNA\u7075\u654f\u6210\u50cf\u7684\u6f5c\u529b\u3002\u800c\u4e14\uff0c\u901a\u8fc7\u8bbe\u8ba1\u5404\u79cdCHARGE\u7535\u8def\uff0c\u4e5f\u53ef\u4ee5\u5b9e\u73b0\u7ec6\u80de\u5185\u5176\u4ed6RNA\uff0c\u86cb\u767d\u8d28\u548c\u5c0f\u5206\u5b50\u7684\u68c0\u6d4b\uff0c\u5e76\u53ef\u4ee5\u8fdb\u4e00\u6b65\u5730\u7528\u4e8e\u9057\u4f20\u8c03\u63a7\u3002\u8be5\u7814\u7a76\u4e3a\u5b9e\u73b0\u9057\u4f20\u7f16\u7801\u7684RNA\u7535\u8def\u5728\u7ec6\u80de\u5185\u5e94\u7528\u5f00\u8f9f\u4e86\u65b0\u7684\u9053\u8def\u3002<\/span><\/p>\n


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\u8be5\u8bba\u6587\u4f5c\u8005\u4e3a\uff1a<\/span><\/strong>Aruni P. K. K. Karunanayake Mudiyanselage, Qikun Yu, Mark A. Leon-Duque, Bin Zhao, Rigumula Wu, Mingxu You*<\/span><\/p>\n

\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762\uff09\uff1a<\/span><\/p>\n

\"\u3010\u5206\u6790\u3011\u57fa\u56e0\u7f16\u7801\u7684RNA\u53d1\u5939\u7ed3\u6784\u7528\u4f5c\u6d3b\u7ec6\u80de\u5185RNA\u7684\u7075\u654f\u6210\u50cf\"<\/p>\n

Genetically Encoded Catalytic Hairpin Assembly for Sensitive RNA Imaging in Live Cells<\/span><\/p>\n

J. Am. Chem. Soc.<\/span><\/em>, 2018<\/strong>, 140<\/em>, 8739-8745, DOI: 10.1021\/jacs.8b03956<\/span><\/p>\n


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\u5bfc\u5e08\u4ecb\u7ecd<\/span><\/p>\n

\u5c24\u660e\u65ed<\/span><\/p>\n

http:\/\/www.x-mol.com\/university\/faculty\/49888<\/span><\/p>\n


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\"\u3010\u5206\u6790\u3011\u57fa\u56e0\u7f16\u7801\u7684RNA\u53d1\u5939\u7ed3\u6784\u7528\u4f5c\u6d3b\u7ec6\u80de\u5185RNA\u7684\u7075\u654f\u6210\u50cf\"<\/p>\n

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\u672c\u6587\u7248\u6743\u5c5e\u4e8eX-MOL<\/strong><\/span>\uff08x-mol.com\uff09\uff0c\u672a\u7ecf\u8bb8\u53ef\u8c22\u7edd\u8f6c\u8f7d\uff01\u6b22\u8fce\u8bfb\u8005\u670b\u53cb\u4eec\u5206\u4eab\u5230\u670b\u53cb\u5708or\u5fae\u535a\uff01<\/span><\/p>\n


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\u957f\u6309<\/strong><\/span>\u4e0b\u56fe\u8bc6\u522b\u56fe\u4e2d\u4e8c\u7ef4\u7801<\/strong>\uff0c\u8f7b\u677e\u5173\u6ce8\u6211\u4eec\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u3010\u5206\u6790\u3011\u57fa\u56e0\u7f16\u7801\u7684RNA\u53d1\u5939\u7ed3\u6784\u7528\u4f5c\u6d3b\u7ec6\u80de\u5185RNA\u7684\u7075\u654f\u6210\u50cf\"<\/p>\n<\/section>\n<\/section>\n

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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587<\/span>\u201d\uff0c\u67e5\u770b \u5316\u5b66 \u2022 \u6750\u6599 <\/strong>\u9886\u57df\u6240\u6709\u6536\u5f55\u671f\u520a<\/span><\/span><\/p>\n

<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u200d\u200d\u200d DNA\u548cRNA\u53ef\u6298\u53e0\u6210\u7cbe\u786e\u7eb3\u7c73\u7ed3\u6784\uff0c\u5df2\u7ecf\u88ab\u5e7f\u6cdb\u8fd0\u7528\u5230\u751f\u7269\u5b66\u548c\u751f\u7269\u533b\u5b66\u7684\u9886\u57df\u4e2d\uff0c\u8fd9\u4e9b\u6838\u9178\u7cbe\u786e\u81ea\u7ec4\u88c5\u7684\u7eb3\u7c73 […]<\/p>\n","protected":false},"author":1,"featured_media":48841,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/48840"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=48840"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/48840\/revisions"}],"predecessor-version":[{"id":48848,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/48840\/revisions\/48848"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/48841"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=48840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=48840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=48840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}