{"id":48869,"date":"2018-09-18T01:00:00","date_gmt":"2018-09-26T01:52:45","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e5%8d%97%e7%a7%91%e5%a4%a7%e8%b0%ad%e6%96%8c%e5%9b%a2%e9%98%9fscience%ef%bc%9a%e4%b8%8d%e5%af%b9%e7%a7%b0%e7%a3%b7%e9%85%b8%e5%82%ac%e5%8c%96ugi%e5%9b%9b%e7%bb%84%e5%88%86%e5%8f%8d%e5%ba%94\/"},"modified":"2018-09-26T09:52:53","modified_gmt":"2018-09-26T01:52:53","slug":"%e5%8d%97%e7%a7%91%e5%a4%a7%e8%b0%ad%e6%96%8c%e5%9b%a2%e9%98%9fscience%ef%bc%9a%e4%b8%8d%e5%af%b9%e7%a7%b0%e7%a3%b7%e9%85%b8%e5%82%ac%e5%8c%96ugi%e5%9b%9b%e7%bb%84%e5%88%86%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/48869\/","title":{"rendered":"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;\"><span style=\"line-height: 0px;\">\u200d\u200d<\/span><span style=\"font-size: 18.018px;line-height: 0px;\">\u200d<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657590253&amp;idx=1&amp;sn=af64055348b35e9185b67c634d7ef95c&amp;chksm=80f7b23db7803b2bc868baa456f16ab2329ba355b97bce33703e32440ef4260a6f34c1ea970a&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-align: center;\"><\/a><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657590253&amp;idx=1&amp;sn=af64055348b35e9185b67c634d7ef95c&amp;chksm=80f7b23db7803b2bc868baa456f16ab2329ba355b97bce33703e32440ef4260a6f34c1ea970a&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-align: center;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;right: auto;bottom: auto;\"><img class=\"\"          style=\"height: 116px;width: 558px;top: auto;left: auto;right: auto;bottom: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1537926766.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/span><\/a><\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657574730&amp;idx=1&amp;sn=7001a26433acb77dcdd5629f27cd8b20&amp;chksm=80f7769ab780ff8cedab5baefd9bc7a02dd18b2191cd29afb2d190e8ea149564133c9437e7d5&amp;scene=21#wechat_redirect\" target=\"_blank\"><\/a><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u968f\u7740\u6709\u673a\u5408\u6210\u5316\u5b66\u7684\u53d1\u5c55\uff0c\u4eba\u4eec\u5bf9\u53cd\u5e94\u672c\u8eab\u7684\u9ad8\u6548\u6027\u3001\u7ecf\u6d4e\u6027\u548c\u666e\u9002\u6027\u8981\u6c42\u8d8a\u6765\u8d8a\u9ad8\uff0c\u5e0c\u671b\u901a\u8fc7\u7b80\u6d01\u7684\u5316\u5b66\u53cd\u5e94\u6b65\u9aa4\u6784\u5efa\u51fa\u65e2\u5177\u6709\u4e00\u5b9a\u590d\u6742\u6027\u7684\u9aa8\u67b6\u53c8\u9ad8\u5ea6\u5b98\u80fd\u56e2\u5316\u7684\u4ea7\u7269\u3002\u5bf9\u4e8e\u5408\u6210\u7b56\u7565\u800c\u8a00\uff0c\u4eba\u4eec\u4e0d\u4ec5\u5e0c\u671b\u5176\u5177\u6709\u9ad8\u6548\u6027\u3001\u6c47\u805a\u6027\uff0c\u66f4\u8981\u6c42\u80fd\u5b9e\u73b0\u591a\u6837\u5bfc\u5411\u6027\u5408\u6210\uff0c\u4ece\u800c\u4e3a\u836f\u7269\u5f00\u53d1\u63d0\u4f9b\u66f4\u591a\u53ef\u80fd\u6027\u3002\u591a\u7ec4\u5206\u53cd\u5e94\u4e2d\uff0c\u4e09\u4e2a\u6216\u4e09\u4e2a\u4ee5\u4e0a\u7684\u8d77\u59cb\u539f\u6599\u6295\u5165\u53cd\u5e94\uff0c\u7528\u201c\u4e00\u9505\u716e\u201d\u7684\u65b9\u6cd5\u6700\u7ec8\u751f\u6210\u4e00\u4e2a\u5f15\u5165\u6240\u6709\u539f\u6599\u7247\u6bb5\u7684\u7ec8\u4ea7\u7269\uff0c\u8fd9\u7c7b\u53cd\u5e94\u88ab\u8ba4\u4e3a\u662f\u8d4b\u4e88\u5408\u6210\u5206\u5b50\u591a\u6837\u6027\u548c\u590d\u6742\u6027\u7684\u6700\u6709\u6548\u624b\u6bb5\u4e4b\u4e00\u3002\u7531\u4e8e\u591a\u7ec4\u5206\u53cd\u5e94\u81ea\u8eab\u6240\u5177\u6709\u7684\u4f18\u52bf\u53ca\u5176\u5728\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u5e94\u7528\uff0c\u591a\u7ec4\u5206\u53cd\u5e94\u7279\u522b\u662f\u4e0d\u5bf9\u79f0\u50ac\u5316\u591a\u7ec4\u5206\u53cd\u5e94\u6210\u4e3a\u4e00\u4e2a\u6781\u5177\u5438\u5f15\u529b\u7684\u7814\u7a76\u9886\u57df\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 18px;\">\u57fa\u4e8e\u5f02\u8148\u7684\u591a\u7ec4\u5206\u53cd\u5e94<\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u5f02\u8148\u662f\u5df2\u77e5\u7684\u552f\u4e00\u4e00\u7c7b\u4ee5\u4e8c\u4ef7\u78b3\u5f62\u5f0f\u7a33\u5b9a\u5b58\u5728\u7684\u6709\u673a\u7269\uff0c\u7279\u6b8a\u7684\u4ef7\u952e\u7ed3\u6784\u548c\u53cd\u5e94\u6d3b\u6027\u8ba9\u5176\u53ef\u4ee5\u540c\u65f6\u4e0e\u4eb2\u7535\u8bd5\u5242\u3001\u4eb2\u6838\u8bd5\u5242\u8fdb\u884c\u53cd\u5e94\uff08\u56fe1a\uff09\u3002\u5f02\u8148\u5728\u5408\u6210\u4e0a\u5177\u6709\u5b9e\u9645\u5e94\u7528\u610f\u4e49\u7684\u7b2c\u4e00\u4e2a\u591a\u7ec4\u5206\u53cd\u5e94\u662f\u7531\u610f\u5927\u5229\u5316\u5b66\u5bb6Mario Passerini\u57281921\u5e74\u62a5\u9053\u7684\u3002\u4ed6\u53d1\u73b0\u5f02\u8148\u3001\u919b\u6216\u916e\u3001\u7fa7\u9178\u53ef\u201c\u4e00\u9505\u201d\u751f\u6210\u03b1-\u9170\u6c27\u57fa\u9170\u80fa\u5316\u5408\u7269\uff08\u56fe1b\uff09\uff0c\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u7fb0\u57fa\u5316\u5408\u7269<strong>2<\/strong>\u548c\u7fa7\u9178\u9996\u5148\u901a\u8fc7\u6c22\u952e\u5f62\u6210\u4e2d\u95f4\u4f53<strong>8<\/strong>\uff0c\u968f\u540e\u5f02\u8148\u7684\u8d1f\u78b3\u4e2d\u5fc3\u8fdb\u653b<strong>8<\/strong>\u4e2d\u4eb2\u7535\u6027\u7fb0\u57fa\u78b3\u539f\u5b50\u5f62\u6210\u8148\u9393\u79bb\u5b50<strong>9<\/strong>\uff0c<strong>9<\/strong>\u8fc5\u901f\u88ab\u7fa7\u9178\u6c27\u539f\u5b50\u6355\u83b7\u5f97\u5230\u4e9a\u6c28\u9178\u916f<strong>10<\/strong>\uff0c<strong>10<\/strong>\u6700\u540e\u901a\u8fc7\u5206\u5b50\u5185\u9170\u57fa\u91cd\u6392\uff08The Mumm rearrangement\uff09\u5f02\u6784\u5f97\u5230\u4ea7\u7269\u5206\u5b50\uff08\u56fe2\uff09\uff0c\u8be5\u53cd\u5e94\u4ee5\u53d1\u73b0\u8005\u7684\u540d\u5b57\u547d\u540d\u4e3aPasserini\u4e09\u7ec4\u5206\u53cd\u5e94\uff08P-3CR\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537926766.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe1. \u57fa\u4e8e\u5f02\u8148\u7684\u591a\u7ec4\u5206\u53cd\u5e94\u2014\u2014P-3CR\u548cU-4CR\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>Acc. Chem. Res.<sup> <\/sup><\/em><\/span><span style=\"color: rgb(136, 136, 136);font-size: 12px;\"><sup>[1]<\/sup><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537926767.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe2. P-3CR\u548cU-4CR\u673a\u7406\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>Acc. Chem. Res<em style=\"text-align: justify;white-space: normal;\">.<\/em><\/em><\/span><span style=\"color: rgb(136, 136, 136);font-size: 12px;\"><em style=\"text-align: justify;white-space: normal;\"><sup>&nbsp;<\/sup><\/em><sup style=\"text-align: justify;white-space: normal;\">[1]<\/sup><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u7136\u800c\uff0c\u7531\u4e8e\u5927\u90e8\u5206\u5f02\u8148\u662f\u5267\u6bd2\u7684\uff0c\u5e76\u4e14\u5f80\u5f80\u6563\u53d1\u51fa\u6076\u81ed\u7684\u6c14\u5473\uff0c\u81ea\u53d1\u73b0\u4ee5\u6765\u57fa\u4e8e\u5f02\u8148\u7684\u591a\u7ec4\u5206\u53cd\u5e94\uff08isocyanide-based multicomponent reaction, IMCR\uff09\u5e76\u672a\u83b7\u5f97\u5316\u5b66\u5bb6\u4eec\u8fc7\u591a\u7684\u5173\u6ce8\u3002\u76f4\u52301959\u5e74\uff0c\u5fb7\u56fd\u5316\u5b66\u5bb6Ivar Karl Ugi\u62a5\u9053\u4e86\u5f02\u8148\u53c2\u4e0e\u7684\u9996\u4e2a\u56db\u7ec4\u5206\u53cd\u5e94\uff0c\u4ed6\u53d1\u73b0\u5f02\u8148\u3001\u919b\u6216\u916e\u3001\u7fa7\u9178\u3001\u80fa\u53ef\u4e00\u6b65\u7f29\u5408\u751f\u6210\u03b1-\u9170\u6c28\u57fa\u9170\u80fa\uff0c\u8be5\u53cd\u5e94\u4e5f\u88ab\u547d\u540d\u4e3aUgi\u56db\u7ec4\u5206\u53cd\u5e94\uff08U-4CR\uff09\u3002U-4CR\u4e0eP-3CR\u5728\u53cd\u5e94\u673a\u7406\u4e0a\u5341\u5206\u76f8\u4f3c\uff08\u56fe2\uff09\uff0c\u552f\u4e00\u4e0d\u540c\u7684\u5730\u65b9\u5728\u4e8eU-4CR\u4e2d\uff0c\u4e0e\u5f02\u8148\u53d1\u751f\u52a0\u6210\u53cd\u5e94\u7684\u4eb2\u7535\u8bd5\u5242\u662f\u7531\u7fb0\u57fa\u5316\u5408\u7269\u4e0e\u80fa\u73b0\u573a\u7f29\u5408\u5f97\u5230\u7684\u4e9a\u80fa\uff08\u5728P-3CR\u4e2d\u4e3a\u919b\u6216\u916e\uff09\u3002\u7531\u4e8eU-4CR\u5c06\u4e00\u5206\u5b50\u80fa\u5f15\u5165\u5230P-3CR\u4e2d\u540e\uff0c\u8ba9\u4ea7\u7269\u80fd\u591f\u901a\u8fc7\u4e00\u4e2a\u78b3\u539f\u5b50\u5c06\u4e24\u4e2a\u9170\u80fa\u7247\u6bb5\u8fde\u63a5\u5728\u4e00\u8d77\uff0c\u8fd9\u8ba9U-4CR\u975e\u5e38\u9002\u5408\u4e8e\u7c7b\u80bd\u836f\u7269\u7684\u5408\u6210\uff0c\u6bd4P-3CR\u62e5\u6709\u66f4\u5e7f\u9614\u7684\u5e94\u7528\u7a7a\u95f4\uff0c\u540c\u65f6\u4e5f\u91cd\u65b0\u71c3\u8d77\u4e86\u5408\u6210\u5316\u5b66\u5bb6\u4eec\u5bf9IMCR\u7279\u522b\u662fU-4CR\u7684\u7814\u7a76\u70ed\u60c5\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 18px;\">Ugi\u56db\u7ec4\u5206\u53cd\u5e94\u7684\u7acb\u4f53\u5316\u5b66\u63a7\u5236\u96be\u9898<\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u81ea1959\u5e74\u9996\u6b21\u53d1\u73b0\u4ee5\u6765\uff0c\u5316\u5b66\u5bb6\u4eec\u5bf9U-4CR\u8fdb\u884c\u4e86\u4e0d\u65ad\u63a2\u7d22\u548c\u6df1\u5165\u7814\u7a76\uff0c\u6781\u5927\u7684\u6269\u5c55\u4e86\u8be5\u7c7b\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\uff0c\u5e76\u5c06\u5176\u5e94\u7528\u4e8e\u5404\u79cd\u751f\u7269\u6d3b\u6027\u5206\u5b50\u3001\u6742\u73af\u836f\u7269\u3001\u5929\u7136\u4ea7\u7269\u7684\u5408\u6210\u4e2d\uff08\u56fe3\uff09\uff0c\u540c\u65f6\u4e5f\u5c06\u6700\u521d\u7684U-4CR\u6f14\u53d8\u6210Ugi\u4e09\u7ec4\u5206\u53cd\u5e94\uff08U-3CR\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537926767.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe3. \u57fa\u4e8eU-4CR\u7684\u751f\u7269\u6d3b\u6027\u5206\u5b50\u3001\u6742\u73af\u836f\u7269\u3001\u5929\u7136\u4ea7\u7269\u7684\u5408\u6210\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>Science<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u76ee\u524d\uff0c\u9ad8\u5ea6\u7acb\u4f53\u9009\u62e9\u6027\u7684U-4CR\u548cU-3CR\u662f\u4e0d\u5bf9\u79f0\u5408\u6210\u9886\u57df\u7684\u4e00\u5927\u7814\u7a76\u70ed\u70b9\u3002\u5c31U-3CR\u800c\u8a00\uff0c\u5176\u5927\u591a\u662f\u540c\u4e00\u4e2a\u5e95\u7269\u4e2d\u5305\u542b\u539f\u6765\u7684\u4e24\u4e2a\u7ec4\u5206\u3002\u5c3d\u7ba1\u8fd1\u5e74\u6765\u5728\u5316\u5b66\u5bb6\u4eec\u7684\u52aa\u529b\u4e0b\uff0c\u5df2\u6709\u4e3a\u6570\u4e0d\u591a\u7684U-3CR\u6210\u529f\u5b9e\u73b0\u4e86\u4e0d\u5bf9\u79f0\u50ac\u5316\u8fc7\u7a0b\uff0c\u4f46\u662f\u8be5\u53cd\u5e94\u6700\u7ec8\u5f97\u5230\u7684\u4ea7\u7269\u5f80\u5f80\u4e0d\u5177\u6709\u7ebf\u6027\u7684\u03b1-\u9170\u6c28\u57fa\u9170\u80fa\u7ed3\u6784\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u867d\u7136U-4CR\u53ef\u4ee5\u4e00\u6b65\u5408\u6210\u03b1-\u9170\u6c28\u57fa\u9170\u80fa\uff0c\u4f46\u5176\u7acb\u4f53\u9009\u62e9\u6027\uff08\u975e\u5bf9\u6620\u9009\u62e9\u6027\uff09\u63a7\u5236\u4f9d\u8d56\u4e8e\u5f53\u91cf\u624b\u6027\u5e95\u7269\u7684\u4f7f\u7528\uff08\u4e3b\u8981\u662f\u624b\u6027\u80fa\uff09\uff0c\u5e76\u4e14\u624b\u6027\u8bf1\u5bfc\u6548\u679c\u5f80\u5f80\u4e0d\u5c3d\u5982\u4eba\u610f\uff08\u56fe4B\uff09\u3002\u76ee\u524d\u9ad8\u5149\u5b66\u7eaf\u03b1-\u9170\u6c28\u57fa\u9170\u80fa\u7684\u5408\u6210\u4e3b\u8981\u662f\u4ee5\u5929\u7136\u6c28\u57fa\u9178\u4e3a\u8d77\u59cb\u539f\u6599\uff0c\u7ecf\u5386\u590d\u6742\u7e41\u7410\u7684\u4fdd\u62a4\u3001\u53bb\u4fdd\u62a4\u3001\u9170\u80fa\u5316\u3001\u8fd8\u539f\u80fa\u5316\u7b49\u64cd\u4f5c\uff08\u56fe4A\uff09\uff0c\u65e2\u589e\u52a0\u4e86\u5408\u6210\u6b65\u9aa4\u3001\u9650\u5236\u4e86\u4ea7\u7269\u7684\u591a\u6837\u6027\uff0c\u4e5f\u4e0d\u7b26\u5408\u539f\u5b50\u7ecf\u6d4e\u6027\u3002\u6beb\u65e0\u7591\u95ee\uff0c\u5982\u679c\u80fd\u901a\u8fc7\u4e0d\u5bf9\u79f0\u50ac\u5316\u7b56\u7565\u5b9e\u73b0U-4CR\u4ea7\u7269\u7acb\u4f53\u5316\u5b66\u7684\u9ad8\u6548\u8c03\u63a7\uff0c\u90a3\u4e48\u624b\u6027\u03b1-\u9170\u6c28\u57fa\u9170\u80fa\u7684\u5408\u6210\u96be\u9898\u5c06\u8fce\u5203\u800c\u89e3\u3002<\/span><\/p>\n<p><br 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18px;\">\u9057\u61be\u5730\u662f\uff0c\u8fd9\u9879\u6781\u5177\u6311\u6218\u6027\u5de5\u4f5c\u7684\u8fdb\u5c55\u5df2\u7ecf\u505c\u6ede\u4e0d\u524d\u8fd160\u5e74\u4e4b\u4e45\uff0c\u5176\u96be\u70b9\u5728\u4e8e\uff1a1\uff09\u5f3a\u70c8\u7684\u975e\u624b\u6027\u80cc\u666f\u53cd\u5e94\uff0c\u5373U-4CR\u65e0\u9700\u50ac\u5316\u5242\u4fbf\u53ef\u5728\u5ba4\u6e29\u4e0b\u5feb\u901f\u53d1\u751f\uff1b2\uff09\u6765\u81eaP-3CR\u548c\u5176\u4ed6\u526f\u53cd\u5e94\u7684\u7ade\u4e89\uff1b3\uff09U-4CR\u7684\u771f\u5b9e\u53cd\u5e94\u673a\u7406\u53ef\u80fd\u5f88\u590d\u6742\uff0c\u5728\u53cd\u5e94\u8fc7\u6e21\u6001\u4e2d\u53ef\u80fd\u5305\u542b\u4e09\u4e2a\u6216\u4e09\u4e2a\u4ee5\u4e0a\u7684\u7ec4\u5206\uff0c\u589e\u52a0\u7684\u53ef\u80fd\u6784\u8c61\u52a0\u5927\u4e86\u63a7\u5236\u7acb\u4f53\u9009\u62e9\u6027\u7684\u96be\u5ea6\uff1b4\uff09U-4CR\u4ea7\u7269\u4e2d\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u751f\u6210\u6e90\u4e8e\u5f02\u8148\u5bf9\u4e9a\u80fa\u7684\u4eb2\u6838\u52a0\u6210\u8fc7\u7a0b\uff0c\u76ee\u524d\u4e0d\u5bf9\u79f0\u50ac\u5316\u5408\u6210\u4e2d\u6d3b\u5316\u4e9a\u80fa\u7684\u624b\u6027\u50ac\u5316\u5242\u65e0\u5916\u4e4e\u8def\u6613\u65af\u9178\u3001\u5e03\u6717\u65af\u7279\u9178\u3001\u914d\u4f53\u87af\u5408\u7684\u91d1\u5c5e\u50ac\u5316\u5242\uff0c\u800cU-4CR\u4e2d\u7684\u7fa7\u9178\u3001\u78b1\u6027\u5e95\u7269\u4ee5\u53ca\u5177\u6709\u53cc\u9f7f\u87af\u5408\u7684\u4ea7\u7269\u90fd\u6709\u53ef\u80fd\u4f7f\u8fd9\u4e9b\u50ac\u5316\u5242\u65e0\u6cd5\u53d1\u6325\u529f\u6548\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1537926768.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe4. \u624b\u6027\u03b1-\u9170\u6c28\u57fa\u9170\u80fa\u7684\u4e09\u79cd\u5408\u6210\u7b56\u7565\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>Science<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"font-size: 18px;\">\u5357\u79d1\u5927\u8c2d\u658c\u6559\u6388\u56e2\u961f\u7684\u91cd\u5927\u7a81\u7834<\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u8fd1\u65e5\uff0c<strong>\u5357\u65b9\u79d1\u6280\u5927\u5b66<\/strong>\u5316\u5b66\u7cfb<strong>\u8c2d\u658c<\/strong>\u6559\u6388\u56e2\u961f\u901a\u8fc7\u4f7f\u7528\u7cbe\u5fc3\u8bbe\u8ba1\u7684<strong>\u624b\u6027\u78f7\u9178\u4f5c\u4e3a\u5e03\u6717\u65af\u7279\u9178\u50ac\u5316\u5242\uff0c<\/strong>\u4ee5\u9ad8\u4ea7\u7387\u548c\u9ad8\u7acb\u4f53\u9009\u62e9\u6027\u5b9e\u73b0\u4e86Ugi\u56db\u7ec4\u5206\u53cd\u5e94\uff08U-4CR\uff09\u7684\u4e0d\u5bf9\u79f0\u50ac\u5316\u8fc7\u7a0b\uff0c<strong>\u7528\u6700\u77ed\u7684\u6b65\u9aa4\uff0c\u9ad8\u539f\u5b50\u7ecf\u6d4e\u6027\u5730\u5408\u6210\u4e86\u4e00\u7cfb\u5217\u542b\u78b3\u624b\u6027\u4e2d\u5fc3\u7684\u03b1-\u9170\u6c28\u57fa\u9170\u80fa\u884d\u751f\u7269<\/strong>\uff08\u56fe4C\uff09\u3002\u8fd9\u4e00\u4e0d\u5bf9\u79f0\u50ac\u5316\u9886\u57df\u7684\u7a81\u7834\u6027\u8fdb\u5c55\uff0c\u7834\u89e3\u4e86\u56f0\u6270\u5316\u5b66\u5bb6\u8fd160\u5e74\u4e4b\u4e45\u7684\u6709\u673a\u5408\u6210\u96be\u9898\u3002\u76f8\u5173\u7ed3\u679c\u4ee5\u201cResearch Article\u201d\u7684\u5f62\u5f0f\u53d1\u8868\u5728\u8fd1\u671f\u7684<strong><em>Science <\/em><\/strong>\u6742\u5fd7\u4e0a\uff0c<strong>\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821<\/strong>\uff08UCLA\uff09\u7684<strong>K. N. Houk<\/strong>\u6559\u6388\u4e3a\u6587\u7ae0\u7684\u53e6\u4e00\u4f4d\u901a\u8baf\u4f5c\u8005\uff0c\u5357\u65b9\u79d1\u6280\u5927\u5b66\u7684\u535a\u58eb\u751f<strong>\u5f20\u5065<\/strong>\uff08\u5408\u6210\u5b9e\u9a8c\u5de5\u4f5c\uff09\u4e0eUCLA\u7684\u535a\u58eb\u540e<strong>\u4f59\u6c9b\u6e90<\/strong>\uff08\u7406\u8bba\u8ba1\u7b97\u5de5\u4f5c\uff09\u4e3a\u6587\u7ae0\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u7b2c\u4e00\u901a\u8baf\u5355\u4f4d\u4e3a\u5357\u65b9\u79d1\u6280\u5927\u5b66\u3002\u610f\u5927\u5229\u70ed\u90a3\u4e9a\u5927\u5b66\u7684Renata Riva\u6559\u6388\u4ee5\u201c<em>Enantioselective four- component Ugi reactions<\/em>\u201d\u4e3a\u9898\u64b0\u6587\u5728\u540c\u671f\u7684<em>Science<\/em>\u6742\u5fd7\u4e0a\u5bf9\u8be5\u5de5\u4f5c\u8fdb\u884c\u4e86\u8bc4\u8ff0<sup>&nbsp;<\/sup><\/span><span style=\"font-size: 14px;\"><sup>[2]<\/sup><\/span><span style=\"font-size: 18px;\">\uff0c\u8ba4\u4e3a\u8fd9\u79cd\u9ad8\u6548\u3001\u666e\u9002\u7684\u4e0d\u5bf9\u79f0\u50ac\u5316\u4f53\u7cfb\u5c06\u4f1a\u5bf9\u836f\u7269\u5316\u5b66\u9886\u57df\u5e26\u6765\u5de8\u5927\u7684\u5e2e\u52a9\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537926768.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u8c2d\u658c\u6559\u6388\uff08\u5de6\uff09\u4e0e\u535a\u58eb\u751f\u5f20\u5065\uff08\u53f3\uff09\u3002\u56fe\u7247\u6765\u6e90\uff1a\u5357\u65b9\u79d1\u6280\u5927\u5b66<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u81ea2004\u5e74\u65e5\u672c\u5316\u5b66\u5bb6Akiyama\u548cTerada\u5206\u522b\u72ec\u7acb\u62a5\u9053\u624b\u6027\u78f7\u9178\u50ac\u5316\u7684\u4e9a\u80fa\u4e0d\u5bf9\u79f0\u4eb2\u6838\u52a0\u6210\u53cd\u5e94\u4ee5\u6765\uff0c\u624b\u6027\u78f7\u9178\u6d3b\u5316C=N\u952e\u6a21\u5f0f\u5df2\u88ab\u6210\u529f\u5e94\u7528\u4e8e\u5404\u7c7b\u6d89\u53ca\u4e9a\u80fa\u4e2d\u95f4\u4f53\u7684\u4e0d\u5bf9\u79f0\u8f6c\u5316\u4e2d\uff0c\u5982Strecker\u53cd\u5e94\u3001Biginelli\u53cd\u5e94\u3001Mannich\u53cd\u5e94\u3001Friedel-Crafts\u53cd\u5e94\u7b49\u3002\u901a\u5e38\uff0c\u624b\u6027\u78f7\u9178\u4e2d\u78f7\u539f\u5b50\u672c\u8eab\u5904\u4e8e\u73af\u72b6\u7ed3\u6784\u4e2d\uff0c\u4f7f\u5176\u4e0d\u80fd\u7ed5\u5355\u952e\u65cb\u8f6c\uff0c\u4ece\u800c\u5177\u6709\u4e00\u5b9a\u7684\u7acb\u4f53\u6784\u578b\uff0c\u901a\u8fc7\u8c03\u8282\u5176\u5468\u56f4\u7684\u53d6\u4ee3\u57fa\u53ef\u4ee5\u6539\u53d8\u5206\u5b50\u5728\u50ac\u5316\u8fc7\u7a0b\u4e2d\u7684\u5bf9\u6620\u9009\u62e9\u6027\u3002\u76f8\u8f83\u4e8e\u7fa7\u9178\uff0c\u624b\u6027\u78f7\u9178\u5177\u6709\u66f4\u5f3a\u7684\u9178\u6027\uff0c\u78f7\u539f\u5b50\u4e0a\u6240\u8fdeOH\u53ef\u4f5c\u4e3a\u5e03\u6717\u65af\u7279\u9178\u7684\u9178\u6027\u4f4d\u70b9\u4f18\u5148\u4e0e\u4e9a\u80fa\u3001\u7fb0\u57fa\u5e95\u7269\u5f62\u6210\u6c22\u952e\uff0c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u78f7\u539f\u5b50\u4e0a\u7684\u53cc\u6c27\u952e\u53ef\u4ee5\u4f5c\u4e3a\u8def\u6613\u65af\u78b1\u6027\u4f4d\u70b9\u63d0\u4f9b\u5b64\u5bf9\u7535\u5b50\uff0c\u4e0e\u7fa7\u9178\u5f62\u6210\u5f02\u4e8c\u805a\u4f53\uff0c\u589e\u5f3a\u78f7\u9178\u9178\u6027\u7684\u540c\u65f6\u63d0\u9ad8\u7fa7\u9178\u7684\u4eb2\u6838\u6027\u3002\u5229\u7528\u624b\u6027\u78f7\u9178\u7684\u8fd9\u4e00\u53cc\u529f\u80fd\u50ac\u5316\u7279\u6027\uff0c\u8c2d\u658c\u6559\u6388\u8bfe\u9898\u7ec4\u66fe\u57282015\u5e74\u6210\u529f\u5b9e\u73b0\u4e86\u4e0d\u5bf9\u79f0\u50ac\u5316P-3CR\uff08\u56fe5\uff09<span style=\"text-align: justify;font-size: 18px;\"><sup>&nbsp;<\/sup><\/span><span style=\"text-align: justify;font-size: 14px;\"><sup>[3]<\/sup><\/span>\u3002\u6b64\u5916\uff0c\u6e05\u534e\u5927\u5b66\u7684\u738b\u6885\u7965\u6559\u6388\u8bfe\u9898\u7ec4\u4e5f\u66fe\u4e8e2016\u5e74\u62a5\u9053\u4e86\u624b\u6027\u78f7\u9178\u50ac\u5316\u7684U-3CR\uff08\u56fe6\uff09<span style=\"font-size: 18px;text-align: justify;\"><sup>&nbsp;<\/sup><\/span><span style=\"text-align: justify;font-size: 14px;\"><sup>[4]<\/sup><\/span><span style=\"font-size: 18px;text-align: justify;\">\u3002<\/span>\u867d\u7136\u79cd\u79cd\u201c\u8ff9\u8c61\u201d\u8868\u660e\u624b\u6027\u78f7\u9178\u53ef\u80fd\u6b63\u662f\u89e3\u51b3U-4CR\u7acb\u4f53\u5316\u5b66\u63a7\u5236\u96be\u9898\u7684\u5173\u952e\u56e0\u7d20\uff08\u56fe7\uff09\uff0c\u4f46\u662f\u8981\u4ece\u201c\u7fb0\u57fa\u578b\u201dP-3CR\u5347\u7ea7\u5230\u201c\u4e9a\u80fa\u578b\u201dU-4CR\u4e5f\u5e76\u975e\u8f7b\u800c\u6613\u4e3e \u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537926769.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537926769.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe5. \u624b\u6027\u78f7\u9178\u50ac\u5316\u4e0d\u5bf9\u79f0P-3CR\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc<em style=\"text-align: justify;white-space: normal;\">.<\/em><\/em><em style=\"text-align: justify;white-space: normal;\"><sup>&nbsp;<\/sup><\/em><\/span><span style=\"color: rgb(136, 136, 136);font-size: 12px;\"><sup style=\"text-align: justify;white-space: normal;\">[3]<\/sup><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537926769-1.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe6. \u624b\u6027\u78f7\u9178\u50ac\u5316\u4e0d\u5bf9\u79f0U-3CR\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>Angew. Chem. Int. Ed<em style=\"text-align: justify;white-space: normal;\">.<sup>&nbsp;<\/sup><\/em><\/em><\/span><span style=\"color: rgb(136, 136, 136);font-size: 12px;\"><sup style=\"text-align: justify;white-space: normal;\">[4]<\/sup><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537926770.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe7. \u624b\u6027\u78f7\u9178\u50ac\u5316U-4CR\u8bbe\u8ba1\u7406\u5ff5\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>Science<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u7ecf\u8fc7\u4e0d\u65ad\u7684\u50ac\u5316\u5242\u8bbe\u8ba1\u548c\u5c1d\u8bd5\uff0c\u4f5c\u8005\u610f\u5916\u5730\u53d1\u73b0\u4f7f\u7528\u5177\u6709\u87ba\u73af\u9aa8\u67b6\u7684\u624b\u6027\u78f7\u9178<strong>CPA6<\/strong>\u65f6\uff0c\u6b63\u620a\u919b<strong>1a<\/strong>\u3001\u5bf9\u785d\u57fa\u82ef\u80fa<strong>2a<\/strong>\u3001\u82ef\u4e19\u9178<strong>3a<\/strong>\u548c\u73af\u5df1\u57fa\u5f02\u8148<strong>4a<\/strong>\u5728\u5ba4\u6e29\u30015\u00c5\u5206\u5b50\u7b5b\u5b58\u5728\u4e0b\u7684CH<\/span><span style=\"font-size: 14px;\"><sub>2<\/sub><\/span><span style=\"font-size: 18px;\">Cl<\/span><span style=\"font-size: 14px;\"><sub>2<\/sub><\/span><span style=\"font-size: 18px;\">\u6eb6\u6db2\u4e2d\u80fd\u4ee564%\u7684\u4ea7\u7387\u300182%\u7684ee\u503c\u751f\u6210\u7ebf\u6027\u7684\u03b1-\u9170\u6c28\u57fa\u9170\u80fa\u4ea7\u7269<strong>5<\/strong>\u3002\u8fdb\u4e00\u6b65\uff0c\u4ed6\u4eec\u5c06\u53cd\u5e94\u6e29\u5ea6\u964d\u4f4e\u5230\u96f6\u4e0b20 \u2103\uff0c\u5e76\u5bf9\u5e95\u7269\u7684\u7528\u91cf\u8fdb\u884c\u4e86\u8c03\u6574\uff0c\u6700\u7ec8\u76ee\u6807\u4ea7\u7269\u7684\u4ea7\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u5927\u5e45\u63d0\u5347\u81f390%\u548c92%\uff08\u56fe8\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1537926770.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe8. \u53cd\u5e94\u6761\u4ef6\u7684\u7b5b\u9009\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>Science<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u4f7f\u7528\u5404\u79cd\u82b3\u9999\u80fa-\u8102\u80aa\u919b\u7ec4\u5408\uff08\u56fe9\uff09\uff0c\u4f5c\u8005\u5728\u6700\u4f73\u6761\u4ef6\u4e0b\u5bf9\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u4e86\u8003\u5bdf\uff0c\u53cd\u5e94\u517c\u5177\u4f18\u79c0\u7684\u4ea7\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\uff0c\u5404\u79cd\u53d6\u4ee3\u7684\u8102\u80aa\u9178\u6216\u82b3\u9999\u9178\u3001\u70f7\u57fa\u5f02\u8148\u6216\u82b3\u57fa\u5f02\u8148\u90fd\u80fd\u987a\u5229\u5730\u751f\u6210\u76ee\u6807\u4ea7\u7269\u3002\u7531\u4e8e\u4e0d\u540c\u7c7b\u578b\u4e9a\u80fa\u7684\u53cd\u5e94\u6027\u8d28\u5dee\u522b\u5f88\u5927\uff0c\u5f53\u4f7f\u7528\u82b3\u9999\u919b-\u8102\u80aa\u80fa\u7ec4\u5408\u65f6\uff0c\u539f\u6709\u7684\u53cd\u5e94\u6761\u4ef6\u5e76\u672a\u53d6\u5f97\u4ee4\u4eba\u6ee1\u610f\u7684\u7ed3\u679c\u3002\u4f5c\u8005\u53c8\u91cd\u65b0\u5bf9\u53cd\u5e94\u6761\u4ef6\u8fdb\u884c\u7b5b\u9009\uff08\u56fe10\uff09\uff0c\u7ecf\u8fc7\u6574\u6574\u4e00\u5e74\u7684\u6478\u7d22\uff0c<\/span><span style=\"font-size: 14px;\"><sup>[5]&nbsp;<\/sup><\/span><span style=\"font-size: 18px;\">\u4ed6\u4eec\u7ec8\u4e8e\u53d1\u73b0\u4f7f\u7528\u53e6\u4e00\u79cd\u624b\u6027\u78f7\u9178<strong>CPA4<\/strong>\u4e3a\u50ac\u5316\u5242\uff0c\u4ee5\u73af\u5df1\u70f7\u4e3a\u6eb6\u5242\u5e76\u572820 \u2103\u4e0b\u8fdb\u884c\u53cd\u5e94\u53ef\u4ee5\u83b7\u5f97\u6700\u4f73\u7ed3\u679c\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537926771.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537926771.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe9. \u8102\u80aa\u919b-\u82b3\u9999\u80fa\u7ec4\u5408\u4e0b\u7684\u4e0d\u5bf9\u79f0U-4CR\u5e95\u7269\u9002\u7528\u8303\u56f4\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>Science<\/em><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537926772.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe10. \u82b3\u9999\u919b-\u8102\u80aa\u80fa\u7ec4\u5408\u4e0b\u7684\u4e0d\u5bf9\u79f0U-4CR\u5e95\u7269\u9002\u7528\u8303\u56f4\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>Science<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u5728\u5b9e\u9a8c\u5b8c\u6210\u540e\uff0c\u6587\u7ae0\u8fdb\u5165\u4e86<em>Science <\/em>\u7684\u7b2c\u4e00\u8f6e\u6295\u7a3f\u8fc7\u7a0b\u3002\u8fd4\u56de\u7684\u5ba1\u7a3f\u610f\u89c1\u662f\u5e0c\u671b\u4f5c\u8005\u80fd\u591f\u63d0\u4f9b\u5145\u5206\u7684\u673a\u7406\u7814\u7a76\u3002\u4e3a\u6b64\uff0c\u8c2d\u658c\u6559\u6388\u8054\u5408UCLA\u7684K. N. Houk\u6559\u6388\u5728\u7406\u8bba\u8ba1\u7b97\u7684\u5c42\u9762\u5bf9\u8fd9\u4e00\u79d1\u5b66\u95ee\u9898\u8fdb\u884c\u4e86\u6df1\u5165\u7814\u7a76\u3002<span style=\"text-align: justify;font-size: 14px;\"><sup>[5]&nbsp;<\/sup><\/span>\u7406\u8bba\u8ba1\u7b97\u7684\u7ed3\u679c\u4e0e\u4ed6\u4eec\u5b9e\u9a8c\u4e4b\u521d\u7684\u8bbe\u60f3\u9ad8\u5ea6\u4e00\u81f4\uff0c\u624b\u6027\u78f7\u9178<strong>1&#8242;<\/strong>\u9996\u5148\u4e0e\u7fa7\u9178<strong>2&#8242;<\/strong>\u5f62\u6210\u4e8c\u805a\u4f53<strong>3&#8242;<\/strong>\uff0c\u968f\u540e\u4e9a\u80fa\u4e0e\u78f7\u9178\u7684\u5e03\u6717\u65af\u7279\u9178\u9178\u6027\u4f4d\u70b9\u914d\u4f4d\u5f62\u6210\u4e09\u805a\u4f53<strong>5&#8242;<\/strong>\uff0c\u7d27\u63a5\u7740\u6d3b\u5316\u7684\u4e9a\u80fa\u63a5\u53d7\u5f02\u8148<strong>6&#8242;<\/strong>\u7684\u4eb2\u6838\u8fdb\u653b\uff0c\u7ecf\u8fc7\u6e21\u6001<strong>TS-1<\/strong>\u751f\u6210\u8148\u9393\u79bb\u5b50\u4e2d\u95f4\u4f53<strong>7&#8242;<\/strong>\uff0c\u7fa7\u9178\u8fdb\u653b\u8148\u9393\u79bb\u5b50\u7ecf\u8fc7\u6e21\u6001<strong>TS-2<\/strong>\u751f\u6210\u4e9a\u6c28\u9178\u916f<strong>8&#8242;<\/strong>\uff0c<strong>8&#8242;<\/strong>\u7ecf\u5feb\u901f\u5730\u9170\u57fa\u91cd\u6392\u5f02\u6784\u4e3a\u03b1-\u9170\u6c27\u57fa\u9170\u80fa<strong>14&#8242;<\/strong>\u3002\u6574\u4e2a\u5386\u7a0b\u4e2d\uff0c\u78f7\u9178\u4e0e\u7fa7\u9178\u4ee5\u6c22\u952e\u65b9\u5f0f\u8fde\u63a5\uff0c\u5e76\u4e00\u540c\u53c2\u4e0e\u4e86\u6240\u6709\u4e2d\u95f4\u4f53\u7684\u751f\u6210\uff0c\u5176\u4e2d\u5f02\u8148\u4e0e\u4e9a\u80fa\u7684\u4eb2\u6838\u52a0\u6210\u4e3a\u53cd\u5e94\u7684\u51b3\u901f\u6b65\u9aa4\uff0c\u5176\u6d3b\u5316\u80fd\u5927\u7ea6\u4e3a15.7 kcal\/mol\uff08\u56fe11\uff09\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u901a\u8fc7DFT\u8ba1\u7b97\u5bf9\u53cd\u5e94\u7684\u7acb\u4f53\u9009\u62e9\u6027\u8fdb\u884c\u4e86\u6a21\u62df\uff0c\u5176\u7ed3\u679c\u4e0e\u5b9e\u9a8c\u6570\u636e\u76f8\u4e00\u81f4\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u6709\u5229\u7684\u5bf9\u6620\u9009\u62e9\u6027\u8fc7\u6e21\u6001\u4e2d\uff0c\u5e95\u7269\u4e2d\u7684\u82b3\u57fa\u503e\u5411\u4e8e\u94bb\u8fdb\u50ac\u5316\u5242\u4e24\u4e2a\u5927\u4f4d\u963b\u53d6\u4ee3\u57fa\u6240\u5f62\u6210\u7684\u624b\u6027\u53e3\u888b\u4e2d\uff0c\u8fd9\u8868\u660e\u975e\u5171\u4ef7\u952e\u76f8\u4e92\u4f5c\u7528\u5728\u63a7\u5236\u53cd\u5e94\u7684\u7acb\u4f53\u9009\u62e9\u6027\u4e2d\u53ef\u80fd\u8d77\u7740\u91cd\u8981\u7684\u4f5c\u7528\uff08\u56fe12\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537926772.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe11. DFT\u8ba1\u7b97\u6a21\u62df\u78f7\u9178\u50ac\u5316U-4CR\u53cd\u5e94\u8def\u5f84\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>Science<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537926773.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe12. DFT\u8ba1\u7b97\u6a21\u62df\u78f7\u9178\u50ac\u5316U-4CR\u7684\u7acb\u4f53\u9009\u62e9\u6027\u3002\u56fe\u7247\u6765\u6e90\uff1a<\/span><em><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">Science<\/span><span style=\"font-size: 18px;\">&nbsp;<\/span><\/em><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><span style=\"color: rgb(33, 127, 188);\"><strong><span style=\"font-size: 18px;\">\u5c0f\u7ed3<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u8c2d\u658c\u6559\u6388\u8bfe\u9898\u7ec4\u5ef6\u7eed\u4ee5\u5f80\u7684\u5de5\u4f5c\uff0c\u4ee5\u624b\u6027\u78f7\u9178\u4f5c\u4e3a\u6709\u673a\u5c0f\u5206\u5b50\u50ac\u5316\u5242\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u9996\u4f8b\u4e0d\u5bf9\u79f0\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\uff0c\u7b80\u5355\u65b9\u4fbf\u7684\u4ece\u56db\u7c7b\u975e\u624b\u6027\u7ed3\u6784\u5355\u5143\u5408\u6210\u4e86\u591a\u8fbe86\u79cd\u901a\u8fc7\u5e38\u89c4\u65b9\u6cd5\u96be\u4ee5\u83b7\u5f97\u7684\u9ad8\u5149\u5b66\u7eaf\u03b1-\u9170\u6c27\u57fa\u9170\u80fa\u3002DFT\u8ba1\u7b97\u63d0\u51fa\u4e86\u8be6\u5c3d\u7684\u53cd\u5e94\u673a\u7406\u548c\u521b\u65b0\u6027\u7684\u7814\u7a76\u7ed3\u8bba\uff0c\u4e5f\u4e3a\u76f8\u5173\u7814\u7a76\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002\u8fd9\u4e00\u4e0d\u5bf9\u79f0\u50ac\u5316\u4f53\u7cfb\u7684\u666e\u9002\u6027\u548c\u591a\u6837\u6027\uff0c\u5c06\u4e3a\u836f\u7269\u5316\u5b66\u5bb6\u5408\u6210\u624b\u6027\u4e8c\u80bd\u7c7b\u5316\u5408\u7269\u63d0\u4f9b\u5f3a\u6709\u529b\u7684\u5de5\u5177\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762\uff09\uff1a<\/span><\/p>\n<p><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537926773.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">Asymmetric phosphoric acid\u2013catalyzed four-component Ugi reaction<\/span><\/p>\n<p><em><span style=\"font-size: 14px;\">Science<\/span><\/em><span style=\"font-size: 14px;\">, <strong>2018<\/strong>, DOI: 10.1126\/science.aas8707<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u5bfc\u5e08\u4ecb\u7ecd<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u8c2d\u658c<\/span><\/p>\n<p><span style=\"font-size: 14px;\">http:\/\/www.x-mol.com\/university\/faculty\/16800<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 14px;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 14px;\">1. Still Unconquered: Enantioselective Passerini and Ugi Multicomponent Reactions. <em>Acc. Chem. Res<\/em>., <strong>2018<\/strong>, <em>51<\/em>, 1290-1300, DOI: 10.1021\/acs.accounts.8b00105<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 14px;\">2. Enantioselective four-component Ugi reactions. <em>Science<\/em>, <strong>2018<\/strong>, <em>361<\/em>, 1072-1073, DOI: 10.1126\/science.aau7497<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 14px;\">3. Phosphoric Acid-Catalyzed Asymmetric Classic Passerini Reaction. <em>J. Am. Chem. Soc<\/em>., <strong>2015<\/strong>, <em>137<\/em>, 14039\u201314042, DOI: 10.1021\/jacs.5b09117<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 14px;\">4. Chiral Phosphoric Acid Catalyzed Asymmetric Ugi Reaction by Dynamic Kinetic Resolution of the Primary Multicomponent Adduct. <em>Angew. Chem. Int. Ed<\/em>.,&nbsp;<strong>2016<\/strong>, <strong>55<\/strong>, 5282-5285, DOI: 10.1002\/anie.201600751<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 14px;\">5. \u5357\u65b9\u79d1\u6280\u5927\u5b66\u5b98\u7f51\u62a5\u9053 http:\/\/www.sustc.edu.cn\/news_events_\/5252<\/span><\/p>\n<p><br  \/><\/p>\n<section style=\"white-space: normal;\">\n<section class=\"Powered-by-XIUMI V5\" >\n<section class=\"\">\n<section class=\"\">\n<p style=\"text-align: center;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657590253&amp;idx=1&amp;sn=af64055348b35e9185b67c634d7ef95c&amp;chksm=80f7b23db7803b2bc868baa456f16ab2329ba355b97bce33703e32440ef4260a6f34c1ea970a&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"font-size: 18.018px;\"><\/a><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657590253&amp;idx=1&amp;sn=af64055348b35e9185b67c634d7ef95c&amp;chksm=80f7b23db7803b2bc868baa456f16ab2329ba355b97bce33703e32440ef4260a6f34c1ea970a&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"font-size: 18.018px;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;right: auto;bottom: auto;\"><img class=\"\"          style=\"height: 116px;width: 558px;top: auto;left: auto;right: auto;bottom: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537926773.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 25.6px;text-align: center;\"><img      style=\"font-size: 18px;background-color: rgb(255, 255, 255);line-height: 25.6px;width: 556px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1537926773.png\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section class=\"\" style=\"height: 16px;box-sizing: border-box;\">\n<section style=\"height: 15.9961px;width: 24px;float: left;border-top: 6px solid rgb(9, 158, 206);border-left: 6px solid rgb(9, 158, 206);border-right-color: rgb(9, 158, 206);border-bottom-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"height: 15.9961px;width: 24px;float: right;border-top: 6px solid rgb(9, 158, 206);border-right: 6px solid rgb(9, 158, 206);border-bottom-color: rgb(9, 158, 206);border-left-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;color: transparent;clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<section class=\"\" style=\"margin: -13px 3px;padding: 12px;border-width: 1px;border-style: solid;border-color: rgb(9, 158, 206);border-radius: 6px;word-wrap: break-word;box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 18px;\">\u672c\u6587\u7248\u6743\u5c5e\u4e8e<span style=\"color: rgb(9, 158, 206);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">X-MOL<\/strong><\/span>\uff08x-mol.com\uff09\uff0c\u672a\u7ecf\u8bb8\u53ef\u8c22\u7edd\u8f6c\u8f7d\uff01\u6b22\u8fce\u8bfb\u8005\u670b\u53cb\u4eec\u5206\u4eab\u5230\u670b\u53cb\u5708or\u5fae\u535a\uff01<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 18px;\"><span style=\"color: rgb(9, 158, 206);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u957f\u6309<\/strong><\/span>\u4e0b\u56fe<strong style=\"box-sizing: border-box;\">\u8bc6\u522b\u56fe\u4e2d\u4e8c\u7ef4\u7801<\/strong>\uff0c\u8f7b\u677e\u5173\u6ce8\u6211\u4eec\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<p style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\"><img class=\"\"     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537926773-1.jpeg\" alt=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\" title=\"\u5357\u79d1\u5927\u8c2d\u658c\u56e2\u961fScience\uff1a\u4e0d\u5bf9\u79f0\u78f7\u9178\u50ac\u5316Ugi\u56db\u7ec4\u5206\u53cd\u5e94\"  \/><\/p>\n<\/section>\n<\/section>\n<section class=\"\" style=\"height: 16px;box-sizing: border-box;\">\n<section style=\"height: 15.9961px;width: 24px;float: left;border-bottom: 6px solid rgb(9, 158, 206);border-left: 6px solid rgb(9, 158, 206);border-top-color: rgb(9, 158, 206);border-right-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"height: 15.9961px;width: 24px;float: right;border-bottom: 6px solid rgb(9, 158, 206);border-right: 6px solid rgb(9, 158, 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