{"id":48905,"date":"2018-09-18T01:00:00","date_gmt":"2018-09-26T01:53:00","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e3%80%90%e5%88%86%e6%9e%90%e3%80%91hairpin-dna%e4%bf%ae%e9%a5%b0%e7%94%b5%e6%9e%81%e8%a1%a8%e9%9d%a2%e5%8f%91%e5%8d%a1%e6%9e%84%e5%9e%8b%e7%9a%84%e8%af%84%e6%b5%8b%e3%80%81%e8%b0%83%e6%8e%a7%e5%8f%8a\/"},"modified":"2018-09-26T09:53:03","modified_gmt":"2018-09-26T01:53:03","slug":"%e3%80%90%e5%88%86%e6%9e%90%e3%80%91hairpin-dna%e4%bf%ae%e9%a5%b0%e7%94%b5%e6%9e%81%e8%a1%a8%e9%9d%a2%e5%8f%91%e5%8d%a1%e6%9e%84%e5%9e%8b%e7%9a%84%e8%af%84%e6%b5%8b%e3%80%81%e8%b0%83%e6%8e%a7%e5%8f%8a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/48905\/","title":{"rendered":"\u3010\u5206\u6790\u3011Hairpin DNA\u4fee\u9970\u7535\u6781\u8868\u9762\u53d1\u5361\u6784\u578b\u7684\u8bc4\u6d4b\u3001\u8c03\u63a7\u53ca\u5176\u4f20\u611f\u6027\u80fd\u7684\u63d0\u5347"},"content":{"rendered":"
\n

\u200d\u200d<\/span>\u200d<\/a>\"\u3010\u5206\u6790\u3011Hairpin<\/span><\/a><\/span><\/a><\/p>\n


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Hairpin DNA\uff08\u4ee5\u4e0b\u7b80\u79f0hpDNA\uff09\u662f\u4e00\u79cd\u80fd\u5f62\u6210\u830e-\u73af\u76f8\u8fde\u201c\u53d1\u5361\u72b6\u201d\u6784\u578b\u7684\u5355\u94feDNA\uff08ssDNA\uff09\u3002\u7531\u4e8ehpDNA\u80fd\u4e0e\u591a\u79cd\u76ee\u6807\u7269\u9ad8\u9009\u62e9\u6027\u7ed3\u5408\u5e76\u5f15\u53d1\u663e\u8457\u7684\u7ed3\u6784\u7ffb\u8f6c\uff0c\u4f5c\u4e3a\u63a2\u9488\u5df2\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5206\u6790\u68c0\u6d4b\u9886\u57df\uff0c\u7279\u522b\u662f\u5728\u57fa\u7247\u4f20\u611f\u5668\u548c\u5206\u5b50\u5668\u4ef6\u7b49\u9886\u57df\u8868\u73b0\u51fa\u7279\u522b\u7684\u4f18\u52bf\u3002\u9700\u8981\u6307\u51fa\u7684\u662f\uff0c\u8fd9\u7c7b\u5668\u4ef6\u7684\u6027\u80fd\u4e3b\u8981\u53d6\u51b3\u4e8ehpDNA\u94fe\u5728\u57fa\u7247\u8868\u9762\u53d1\u5361\u6784\u578b\u7684\u9ad8\u6548\u201c\u5e94\u6fc0\u201d\u7ffb\u8f6c\uff0c\u800c\u5728\u57fa\u7247\uff08\u7535\u6781\u3001\u82af\u7247\u7b49\uff09\u8868\u9762\u9ad8\u4ea7\u7387\u5730\u5f62\u6210\u53d1\u5361\u6784\u578b\u662f\u4fdd\u969c\u5176\u7ed3\u6784\u7ffb\u8f6c\u7684\u524d\u63d0\u3002\u68d8\u624b\u7684\u662f\uff0chpDNA\u5728\u6eb6\u6db2\u4e2d\u5e38\u4ee5\u6df7\u5408\u6784\u578b\uff08\u5373\u5355\u94fe\u5377\u66f2\u6784\u578b\u3001\u53d1\u5361\u6784\u578b\u3001\u5934-\u5c3e\u76f8\u8fde\u4e8c\u805a\u4f53\u6784\u578b\uff09\u7684\u5f62\u5f0f\u5b58\u5728\uff0c\u56e0\u800c\u7ec4\u88c5\u5230\u57fa\u7247\u8868\u9762\u7684\u901a\u5e38\u4e5f\u662f\u5177\u6709\u6df7\u5408\u6784\u578b\u7684\u63a2\u9488\u819c\u3002\u66f4\u4e3a\u9057\u61be\u7684\u662f\uff0c\u76ee\u524d\u4e0d\u4ec5\u7f3a\u4e4f\u4fc3\u4f7fhpDNA\u63a2\u9488\u5728\u57fa\u7247\u8868\u9762\u9ad8\u6548\u5f62\u6210\u53d1\u5361\u6784\u578b\u7684\u6709\u6548\u7ec4\u88c5\u5de5\u827a\uff0c\u8fd8\u7279\u522b\u6b20\u7f3a\u5b9a\u91cf\u8bc4\u4ef7hpDNA\u63a2\u9488\u5728\u57fa\u7247\u5b9e\u9645\u5f62\u6210\u53d1\u5939\u6784\u578b\u4ea7\u7387\u7684\u7b80\u4fbf\u65b9\u6cd5\uff0c\u66f4\u4e0d\u7528\u8bf4\u5bf9\u53d1\u5939\u6784\u578b\u8fdb\u884c\u539f\u4f4d\u8c03\u63a7\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u6700\u8fd1\uff0c\u5317\u4eac\u5e08\u8303\u5927\u5b66<\/strong>\u7684\u674e\u8fd0\u8d85<\/strong>\u6559\u6388\u8bfe\u9898\u7ec4\u4e0e\u52a0\u62ff\u5927Simon Fraser\u5927\u5b66<\/strong>\u7684\u4e8e\u5316\u5fe0<\/strong>\u6559\u6388\u8bfe\u9898\u7ec4\u5408\u4f5c\uff0c\u5c06Exo I\uff08\u4e00\u79cdDNA\u7279\u5f02\u6027\u5916\u5207\u9176\uff0c\u53ef\u5c06ssDNA\u4ece3’\u7aef\u52305’\u7aef\u9010\u6b65\u6c34\u89e3\u6210\u5355\u6838\u82f7\u9178\uff09\u5bf9ssDNA\u9009\u62e9\u6027\u526a\u5207\u7684\u80fd\u529b\u548cRu(NH<\/span>3<\/sub><\/span>)<\/span>6<\/sub>3+<\/sup><\/span>\u5bf9DNA\u94fe\u7535\u5316\u5b66\u5b9a\u91cf\u6807\u8bb0\u7684\u80fd\u529b\u76f8\u7ed3\u5408\uff0c\u5b9e\u73b0\u4e86\u5bf9\u7535\u6781\u8868\u9762hpDNA\u53d1\u5361\u72b6\u6784\u578b\u7684\u5b9a\u91cf\u8bc4\u6d4b\u4e0e\u53ef\u63a7\u8c03\u63a7\uff0c\u5e76\u8fdb\u4e00\u6b65\u8bbe\u8ba1\u51fa\u9ad8\u7075\u654f\u7684hpDNA\u57fa\u751f\u7269\u4f20\u611f\u5668\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4ed6\u4eec\u9996\u5148\u501f\u52a9\u51dd\u80f6\u7535\u6cf3\uff08gel\uff09\u3001\u7535\u5316\u5b66\u5faa\u73af\u4f0f\u5b89\uff08CV\uff09\u6280\u672f\u4ee5\u53ca\u7535\u55b7\u96fe\u8d28\u8c31\uff08ESI-MS\uff09\u6280\u672f\uff0c\u53d1\u73b0\u5e76\u5efa\u7acb\u4e86\u4e00\u79cd\u80fd\u6709\u6548\u533a\u5206\u7535\u6781\u8868\u9762\u56fa\u5b9a\u7684ssDNA\u548chpDNA\u7684\u201cExo I\u6c34\u89e3\u8f85\u52a9\u6784\u578b\u533a\u5206\u6cd5\u201d\uff0c\u5373\u5229\u7528\u9002\u4e2d\u6d3b\u6027\u7684Exo I\u80fd\u9ad8\u6548\u201c\u5254\u9664\u201dssDNA\u800c\u201c\u5b8c\u597d\u201d\u4fdd\u7559hpDNA\u94fe\u7684\u6c34\u89e3\u7279\u6027\u3002\u4ed6\u4eec\u8fd8\u53d1\u73b0Exo I\u5bf9ssDNA\u94fe\u7684\u6c34\u89e3\u4f5c\u7528\u4f1a\u53d7\u5230\u57fa\u7247\u4f4d\u963b\u6548\u5e94\u7684\u663e\u8457\u5f71\u54cd\uff0c\u901a\u5e38\u4f1a\u7559\u4e0b12\u4e2a\u78b1\u57fa\u5de6\u53f3\u7684\u6b8b\u4f59\u7247\u6bb5\uff08Anal. Chem<\/em>., 2017<\/strong>, 89<\/em>, 2464\uff09\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u4ed6\u4eec\u5229\u7528Ru(NH3<\/sub><\/span>)<\/span>6<\/sub>3+<\/sup><\/span>\u63a2\u9488\u7684\u7535\u5316\u5b66\u6807\u8bb0\u4e0e\u5b9a\u91cf\u529f\u80fd\uff0c\u901a\u8fc7\u5b9a\u91cf\u6bd4\u8f83\u7535\u6781\u8868\u9762\u5728Exo I\u6c34\u89e3\u524d\uff08\u6df7\u5408\u819c\uff09\u548c\u6c34\u89e3\u540e\uff08\u7eafhpDNA\u819c\uff09\u6240\u56fa\u5b9aDNA\u94fe\u6570\u91cf\uff08\u53ef\u7528\u79ef\u5206\u7535\u91cf\u8868\u793a\uff09\u7684\u53d8\u5316\uff0c\u5b9e\u73b0\u4e86\u5b9a\u91cf\u8bc4\u6d4b\u7535\u6781\u8868\u9762\u56fa\u5b9ahpDNA\u94fe\u7684\u6570\u91cf\u4ee5\u53ca\u6bd4\u4f8b\u8fd9\u4e00\u201c\u68d8\u624b\u201d\u76ee\u6807\u3002\u5229\u7528\u8fd9\u4e00\u65b9\u6cd5\uff0c\u4ed6\u4eec\u7cfb\u7edf\u63a2\u7a76\u4e86\u7ec4\u88c5\u6eb6\u6db2\u4e2dDNA\u7ec4\u6210\uff08\u5373ssDNA\/hpDNA\u6bd4\u503c\uff09\u4e0e\u7535\u6781\u8868\u9762\u7ec4\u88c5\u819c\u4e2d\u8fd9\u4e24\u79cdDNA\u6784\u578b\u6bd4\u4f8b\u4e4b\u95f4\u7684\u5173\u8054\u6027\uff1b\u63ed\u793a\u4e86\u94fe\u5bc6\u5ea6\u5bf9\u53d1\u5939\u6784\u578b\u5f62\u6210\u4ea7\u7387\u7684\u663e\u8457\u5f71\u54cd\u3002\u6b64\u5916\uff0c\u4ed6\u4eec\u8fd8\u91c7\u7528\u201c\u77ed\u94feDNA\u9009\u62e9\u6742\u4ea4\u7b56\u7565\u201d\u9a8c\u8bc1\u4e86Exo I\u6c34\u89e3\u8f85\u52a9\u7535\u5316\u5b66\u6784\u578b\u8bc4\u6d4b\u8fd9\u4e00\u65b9\u6cd5\u7684\u53ef\u9760\u6027\u3002<\/span><\/p>\n

\"\u3010\u5206\u6790\u3011Hairpin<\/p>\n


<\/span><\/p>\n

\u66f4\u91cd\u8981\u7684\u662f\uff0c\u4ed6\u4eec\u8fd8\u53d1\u73b0Exo I\u5728\u8f85\u52a9\u6784\u578b\u5b9a\u91cf\u7684\u540c\u65f6\uff0c\u8fd8\u53ef\u6709\u6548\u6d88\u9664\u7531\u975e\u53d1\u5361\u6784\u578b\u5f15\u8d77\u7684\u80cc\u666f\u4fe1\u53f7\uff0c\u4ece\u800c\u663e\u8457\u63d0\u9ad8hpDNA\u57fa\u751f\u7269\u4f20\u611f\u5668\u7684\u54cd\u5e94\u6027\u80fd\u3002\u4ee5\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2-1\uff08\u5373HIV-1\uff09\u57fa\u56e0\u7247\u6bb5\u68c0\u6d4b\u4e3a\u4f8b\uff0c\u7ecfExo I\u201c\u4fee\u6574\u201d\u7684hpDNA\u57fa\u7535\u5316\u5b66\u4f20\u611f\u5668\u53ef\u5c06\u68c0\u6d4b\u9650\u964d\u4f4e\u5230\u672a\u5904\u7406\u524d\u76841\/120\u3002\u6b64\u5916\uff0c\u4ece\u539f\u7406\u4e0a\u8bb2\uff0cExo I\u8f85\u52a9\u7684\u6784\u578b\u5b9a\u91cf\u8bc4\u6d4b\u548c\u80cc\u666f\u6d88\u9664\u7b56\u7565\u8fd8\u53ef\u9002\u7528\u4e8e\u5176\u4ed6\u5177\u6709\u7279\u6b8a\u6784\u578b\u7684DNA\u4f53\u7cfb\uff08\u5982G-\u56db\u8fde\u4f53\u3001i-motif\u3001Y-shape\u7b49)\uff0c\u56e0\u6b64\u5bf9\u6784\u5efa\u9ad8\u7075\u654f\u5ea6\u751f\u7269\u4f20\u611f\u5668\u53caDNA\u5206\u5b50\u5668\u4ef6\u5177\u6709\u5e7f\u6cdb\u800c\u53c8\u91cd\u8981\u7684\u610f\u4e49\u3002<\/span><\/p>\n

\"\u3010\u5206\u6790\u3011Hairpin<\/p>\n


<\/p>\n

\u8fd9\u4e00\u6210\u679c\u8fd1\u671f\u53d1\u8868\u5728<\/span>Analytical Chemistry <\/em><\/strong><\/span>\u4e0a\uff0c\u6587\u7ae0\u7684\u7b2c\u4e00\u4f5c\u8005\u662f\u5317\u4eac\u5e08\u8303\u5927\u5b66\u7684\u535a\u58eb\u7814\u7a76\u751f\u9ad8\u6653\u6021<\/strong>\u3002\u8be5\u5de5\u4f5c\u53d7\u5230\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u9762\u4e0a\u9879\u76ee\uff08No.21573024\uff09\u7684\u652f\u6301\u3002<\/span><\/p>\n


<\/p>\n

\u8be5\u8bba\u6587\u4f5c\u8005\u4e3a\uff1a<\/span><\/strong>Xiaoyi Gao, Xinglin Wang, Yunchao Li, Jiale He, and Hua-Zhong Yu<\/span><\/p>\n

\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762\uff09\uff1a<\/span><\/p>\n

\"\u3010\u5206\u6790\u3011Hairpin<\/p>\n

Exonuclease I\u2011Hydrolysis Assisted Electrochemical Quantitation of Surface-Immobilized DNA Hairpins and Improved HIV\u20111 Gene Detection<\/span><\/p>\n

Anal. Chem.<\/span><\/em>, 2018<\/strong>, 90<\/em>, 8147, DOI: 10.1021\/acs.analchem.8b01445<\/span><\/p>\n


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\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/span><\/strong><\/p>\n


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\u674e\u8fd0\u8d85<\/span><\/p>\n

http:\/\/www.x-mol.com\/university\/faculty\/49886<\/span><\/p>\n

\u4e8e\u5316\u5fe0<\/span><\/p>\n

http:\/\/www.x-mol.com\/university\/faculty\/49887<\/span><\/p>\n


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\u79d1\u7814\u601d\u8def\u5206\u6790<\/span><\/strong><\/p>\n


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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587<\/span>\u201d\uff0c\u67e5\u770b \u5316\u5b66 \u2022 \u6750\u6599 <\/strong>\u9886\u57df\u6240\u6709\u6536\u5f55\u671f\u520a<\/span><\/span><\/p>\n

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\u200d\u200d\u200d \u6ce8\uff1a\u6587\u672b\u6709\u7814\u7a76\u56e2\u961f\u7b80\u4ecb \u53ca\u672c\u6587\u4f5c\u8005\u79d1\u7814\u601d\u8def\u5206\u6790 Hairpin DNA\uff08\u4ee5\u4e0b\u7b80\u79f0hpDNA\uff09 […]<\/p>\n","protected":false},"author":1,"featured_media":48906,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/48905"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=48905"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/48905\/revisions"}],"predecessor-version":[{"id":48914,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/48905\/revisions\/48914"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/48906"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=48905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=48905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=48905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}