{"id":4897,"date":"2018-06-17T01:00:00","date_gmt":"2018-07-27T06:57:48","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e5%88%86%e4%ba%ab-%e5%b9%b2%e7%b2%89%e5%90%b8%e5%85%a5%e5%88%b6%e5%89%82%e4%b8%ad%e7%b2%89%e6%9c%ab%e7%89%b9%e6%80%a7%e5%8f%8a%e5%a4%84%e6%96%b9%e6%a8%a1%e5%bc%8f\/"},"modified":"2018-07-27T14:57:49","modified_gmt":"2018-07-27T06:57:49","slug":"%e5%88%86%e4%ba%ab-%e5%b9%b2%e7%b2%89%e5%90%b8%e5%85%a5%e5%88%b6%e5%89%82%e4%b8%ad%e7%b2%89%e6%9c%ab%e7%89%b9%e6%80%a7%e5%8f%8a%e5%a4%84%e6%96%b9%e6%a8%a1%e5%bc%8f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/4897\/","title":{"rendered":"\u5206\u4eab | \u5e72\u7c89\u5438\u5165\u5236\u5242\u4e2d\u7c89\u672b\u7279\u6027\u53ca\u5904\u65b9\u6a21\u5f0f"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;text-align: center;\"><strong style=\"max-width: 100%;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u7f6e\u9876\u201c<\/span><\/span><strong style=\"font-size: 16px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 82, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/span><\/span><\/span><\/strong><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u201d\uff0c\u83b7\u53d6\u6700\u65b0\u8d44\u8baf<\/span>\uff01<\/span><\/span><\/strong><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"font-size: 12px;\">\u6587\u7ae0\u8f6c\u81ea\u4e2d\u56fd\u533b\u836f\u5de5\u4e1a\u6742\u5fd7\uff0c\u8f6c\u8f7d\u65e8\u5728\u5b66\u4e60\u4ea4\u6d41\u3001\u4e0d\u4f5c\u4efb\u4f55\u5546\u4e1a\u7528\u9014\uff0c\u5982\u6d89\u4fb5\u6743\u70e6\u8bf7\u8054\u7cfb\u5e73\u53f0\u8fdb\u884c\u5220\u9664\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5e72\u7c89\u5438\u5165\u5236\u5242\u4e2d\u7c89\u672b\u7279\u6027\u53ca\u5904\u65b9\u6a21\u5f0f<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">Powder Characteristics and Formulation Patterns of Dry Powder Inhalers<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u6731\u4e07\u8f89\uff0c\u5434\u95fb\u54f2*<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">(\u4e2d\u56fd\u533b\u836f\u5de5\u4e1a\u7814\u7a76\u603b\u9662\u836f\u7269\u5236\u5242\u56fd\u5bb6\u5de5\u7a0b\u7814\u7a76\u4e2d\u5fc3\uff0c\u4e0a\u6d77 201203)<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;padding-right: 13px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: -1.55em;padding: 10px;max-width: 100%;box-sizing: border-box;border-radius: 0px 1.5em;border-width: 1px 3px 1px 1px;border-style: solid;border-color: rgb(192, 200, 209) rgb(169, 178, 54) rgb(192, 200, 209) rgb(192, 200, 209);background-color: rgb(250, 250, 239);box-shadow: rgb(170, 170, 170) 0px 0px 10px;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: left;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6458\u8981\uff1a<\/strong>\u5e72\u7c89\u5438\u5165\u5236\u5242\u4f5c\u4e3a\u533b\u836f\u884c\u4e1a\u8fd1\u5e74\u6765\u7684\u7814\u7a76\u70ed\u70b9\uff0c\u5177\u6709\u975e\u5e38\u4f18\u8d8a\u7684\u5e94\u7528\u524d\u666f\uff0c\u5176\u7814\u53d1\u751f\u4ea7\u5bf9\u5e72\u7c89\u7684\u7c89\u672b\u7279\u6027\u5177\u6709\u4e25\u683c\u7684\u8981\u6c42\u3002\u836f\u7269\ufe51\u8f7d\u4f53\u53ca\u6dfb\u52a0\u5242\u7684\u7269\u6599\u6027\u8d28\ufe51\u73af\u5883\u4ee5\u53ca\u5904\u7406\u6761\u4ef6\u5219\u51b3\u5b9a\u4e86\u5404\u79cd\u7c92\u5b50\u95f4\u4f5c\u7528\u529b\u7684\u76f8\u5bf9\u5927\u5c0f\uff0c\u8fdb\u800c\u5f71\u54cd\u7c89\u672b\u7684\u5b8f\u89c2\u6027\u8d28\u3002\u901a\u8fc7\u591a\u79cd\u624b\u6bb5\u4e86\u89e3\u5e72\u7c89\u7684\u7c89\u672b\u7279\u6027\uff0c\u9009\u62e9\u6700\u4f18\u7684\u5904\u7406\u6761\u4ef6\ufe51\u5904\u65b9\u6a21\u5f0f\ufe51\u88c5\u7f6e\u8bbe\u8ba1\u662f\u5e72\u7c89\u5438\u5165\u5236\u5242\u7814\u53d1\u7684\u5173\u952e\u3002<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: left;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5173\u952e\u8bcd\uff1a<\/strong>\u5e72\u7c89\u5438\u5165\u5236\u5242\uff1b\u7c89\u672b\u7279\u6027\uff1b\u5904\u65b9\u6a21\u5f0f\uff1b\u7efc\u8ff0<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\" style=\"margin-top: -1px;margin-right: -2px;margin-left: auto;max-width: 100%;box-sizing: border-box;width: 6px;height: 6px;border-radius: 50%;background-color: rgb(169, 178, 54);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: middle;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: -8px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;float: left;width: 3px;height: 8px;background-color: rgb(188, 169, 93);word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;float: left;width: 3px;height: 8px;background-color: rgb(188, 169, 93);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;float: left;width: 3px;height: 8px;background-color: rgb(188, 169, 93);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;float: right;width: 3px;height: 8px;background-color: rgb(188, 169, 93);word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;clear: both;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section class=\"\" style=\"padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;border-top: 3px solid rgb(188, 169, 93);border-bottom: 3px solid rgb(188, 169, 93);border-right-color: rgb(188, 169, 93);border-left-color: rgb(188, 169, 93);font-size: 18px;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u4ee5\u4e0b\u4e3a\u6587\u7ae0\u8282\u9009<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5e72\u7c89\u5438\u5165\u5242(dry powder inhaler\uff0cDPI) \u53c8\u79f0\u7c89\u96fe\u5242\uff0c\u6307\u7684\u662f\u5fae\u7ec6\u7c92\u5b50\u836f\u7269\u5355\u72ec\u6216\u4e0e\u8f7d\u4f53\u6df7\u5408\uff0c\u8d2e\u5b58\u4e8e\u80f6\u56ca\u3001\u6ce1\u56ca\u6216\u591a\u5242\u91cf\u50a8\u5e93\u4e2d\uff0c\u5229\u7528\u60a3\u8005\u5438\u6c14\u4ea7\u751f\u7684\u6c14\u6d41\uff0c\u4f5c\u7528\u4e8e\u7279\u522b\u8bbe\u8ba1\u7684\u5e72\u7c89\u5438\u5165\u88c5\u7f6e\uff0c\u4f7f\u88c5\u7f6e\u4ea7\u751f\u7684\u6e4d\u52a8\u6c14\u6d41\u6765\u96fe\u5316\u548c\u6392\u7a7a\u836f\u7269\uff0c\u5c06\u5206\u6563\u7684\u836f\u7269\u9012\u9001\u81f3\u80ba\u90e8\uff0c\u4ece\u800c\u4ea7\u751f\u7597\u6548\u7684\u5236\u5242\u3002DPI \u4e0d\u542b\u629b\u5c04\u5242\uff0c\u591a\u4e3a\u547c\u5438\u9a71\u52a8\uff0c\u5373\u201c\u88ab\u52a8\u5f0f\u201d\u3002DPI \u5177\u6709\u4f17\u591a\u4f18\u52bf\uff0c\u5982\uff1a\u4e0d\u542b\u6c22\u6c1f\u70f7\u70c3\u7c7b\u629b\u5c04\u5242\uff0c\u907f\u514d\u73af\u5883\u6c61\u67d3\uff1b\u5bf9\u4e8e\u591a\u80bd\u548c\u86cb\u767d\u8d28\u836f\u7269\uff0c\u5e72\u7c89\u7684\u5ba4\u6e29\u7a33\u5b9a\u6027\u597d\u4e14\u5438\u5165\u7684\u6548\u7387\u9ad8\uff0c\u4e0d\u6613\u88ab\u5fae\u751f\u7269\u6c61\u67d3\u7b49[1]\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">DPI \u662f\u76f8\u5f53\u590d\u6742\u7684\u836f\u7269\u9012\u9001\u7cfb\u7edf\uff0c\u8981\u505a\u5230\u7cbe\u786e\u5206\u914d\u5242\u91cf\uff0c\u9012\u9001\u836f\u7269\u5230\u5438\u5165\u6c14\u6d41\uff0c\u5e76\u5c06\u7c89\u672b\u89e3\u805a\u6210\u53ef\u5438\u5165\u7684\u9897\u7c92\uff0c\u5176\u6027\u80fd\u53d6\u51b3\u4e8e\u4ee5\u4e0b\u56e0\u7d20[2]\uff1a\u2460\u836f\u7c89\uff1b\u2461\u5904\u65b9\uff1b\u2462\u6c14\u6eb6\u80f6\u7684\u4ea7\u751f\u548c\u7ecf\u5438\u5165\u88c5\u7f6e\u9012\u9001\u3002\u800cDPI \u4e2d\u7c89\u672b\u7684\u7279\u6027\u548c\u5904\u65b9\u662f\u5f71\u54cd\u5176\u4f53\u5185\u5916\u5438\u5165\u6548\u679c\u7684\u91cd\u8981\u56e0\u7d20\u3002\u672c\u6587\u5c31\u7c89\u672b\u7684\u5927\u5c0f\u5f62\u6001\u3001\u6d41\u52a8\u6027\u3001\u7535\u6027\u3001\u5206\u6563\u6027\u548c\u5438\u6e7f\u6027\u7b49\u7279\u6027\u53ca\u5904\u65b9\u6a21\u5f0f\u8fdb\u884c\u7efc\u8ff0\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">1 \u5e72\u7c89\u5438\u5165\u5236\u5242\u7684\u7c89\u672b\u7279\u6027<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u7c89\u4f53\u4e2d\u7684\u9897\u7c92\u672c\u8eab\u590d\u6742\u591a\u53d8\uff0c\u9700\u8981\u7528\u4e00\u7cfb\u5217\u7406\u5316\u6027\u8d28\u6765\u63cf\u8ff0\uff1a\u7c92\u5f84\u53ca\u7c92\u5ea6\u5206\u5e03\u3001\u5f62\u72b6\u3001\u8868\u9762\u6784\u9020\u3001\u8868\u9762\u79ef\u3001\u5bc6\u5ea6\u3001\u5185\u805a\u3001\u9ecf\u9644\u6027\u3001\u5f39\u6027\u3001\u5851\u6027\u3001\u5b54\u9699\u7387\u3001\u4ea7\u751f\u9759\u7535\u7684\u53ef\u80fd\u6027\u3001\u5438\u6e7f\u6027\u3001\u786c\u5ea6\u53ca\u8106\u788e\u6027\u3001\u975e\u6676\u578b\u542b\u91cf\u7b49\u3002\u73b0\u4ece\u51e0\u4e2a\u5f71\u54cdDPI \u6027\u80fd\u7684\u4e3b\u8981\u65b9\u9762\u505a\u7b80\u8981\u9610\u8ff0\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">1.1 \u7c92\u5f84\u5927\u5c0f\u3001\u5bc6\u5ea6\u4e0e\u8868\u9762\u5f62\u8c8c<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u4e00\u822c\u6765\u8bf4\uff0c\u572860 L\/min \u7684\u6d41\u901f\u4e0b\uff0c\u5927\u4e8e5 \u03bcm\u7684\u7c92\u5b50\u5bb9\u6613\u78b0\u649e\u843d\u5728\u54bd\u5589\u90e8\u4f4d\uff0c\u800c\u5c0f\u4e8e5 \u03bcm \u7684\u7c92\u5b50\u66f4\u5bb9\u6613\u88ab\u9012\u9001\u5230\u652f\u6c14\u7ba1[3]\u3002\u7c92\u5f84\u5927\u5c0f\u662f\u5f71\u54cd\u5438\u5165\u6027\u80fd\u7684\u5173\u952e\u56e0\u7d20\u3002\u7531\u4e8e\u5b9e\u9645\u4e2d\u9897\u7c92\u7684\u5f62\u6001\u901a\u5e38\u4e0d\u89c4\u5219\uff0c\u56e0\u6b64\u865a\u62df\u4e00\u4e2a\u5177\u6709\u76f8\u540c\u8868\u9762\u79ef\u6216\u76f8\u540c\u4f53\u79ef\u7684\u7403\u4f53\uff0c\u5c06\u5b83\u4f5c\u4e3a\u88ab\u6d4b\u5b9a\u7c92\u5b50\u7684\u7b49\u4ef7\u7403\u4f53\u3002\u7528\u8fd9\u4e00\u7b49\u4ef7\u7403\u4f53\u7684\u76f4\u5f84\u4ee3\u8868\u88ab\u6d4b\u5b9a\u7684\u5f62\u6001\u4e0d\u89c4\u5219\u7684\u7c92\u5b50\u7c92\u5f84\uff0c\u6d4b\u5f97\u7684\u76f4\u5f84\u79f0\u4e3a\u7403\u5f62\u7b49\u4ef7\u5f84(diameter of an equivalent sphere\uff0cDe)\u3002\u7136\u800c\uff0c\u6c14\u96fe\u4e2d\u7c92\u5b50\u591a\u4e3a\u8fd0\u52a8\u7c92\u5b50\uff0c\u5176\u884c\u4e3a\u53c8\u4e0e\u9759\u6b62\u7c92\u5b50\u4e0d\u540c\u3002\u6240\u4ee5\u76ee\u524d\u8ba4\u4e3a\uff0c\u6bd4\u8f83\u5408\u7406\u7684\u65b9\u6cd5\u662f\u4f7f\u7528\u7a7a\u6c14\u52a8\u529b\u5b66\u7c92\u5f84(aerodynamic diameter\uff0cDa) \u6765\u8bc4\u4f30\u6c14\u96fe\u7c92\u5b50\u7c92\u5f84\u30022 \u79cd\u7c92\u5f84\u7684\u5173\u7cfb\u5982\u4e0b\u5f0f\u6240\u793a\u3002<img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532674669.jpeg\" alt=\"\u5206\u4eab | \u5e72\u7c89\u5438\u5165\u5236\u5242\u4e2d\u7c89\u672b\u7279\u6027\u53ca\u5904\u65b9\u6a21\u5f0f\" title=\"\u5206\u4eab | \u5e72\u7c89\u5438\u5165\u5236\u5242\u4e2d\u7c89\u672b\u7279\u6027\u53ca\u5904\u65b9\u6a21\u5f0f\"  \/>\u5176\u4e2d\uff0c\u03c1 \u4e3a\u6709\u6548\u9897\u7c92\u5bc6\u5ea6\uff0c\u03c10 \u4e3a\u53c2\u7167\u5bc6\u5ea6( \u7b49\u4e8e1 g\/cm3)\uff0cX \u4e3a\u52a8\u6001\u5f62\u6001\u56e0\u5b50( \u7403\u5f62\u65f6\uff0cX=1)\u3002\u8fd9\u5c31\u5c06\u7c92\u5b50\u7684\u5927\u5c0f\u3001\u5bc6\u5ea6\u548c\u5f62\u6001\u8054\u7cfb\u8003\u8651\uff0c\u5e76\u7531\u4e00\u4e2a\u503c\u8868\u793a\u3002\u7c92\u5b50\u7684\u5f62\u6001\u5343\u53d8\u4e07\u5316\uff0c\u6709\u9488\u5f62\u3001\u7403\u5f62\u3001\u591a\u89d2\u5f62\u3001\u679d\u72b6\u3001\u7ea4\u7ef4\u72b6\u548c\u7247\u72b6\u7b49\u3002\u5982\u679c\u7c92\u5b50\u5f62\u6001\u4e0d\u89c4\u5219\u6216\u504f\u79bb\u7403\u4f53\u8f83\u8fdc\uff0c\u4f1a\u663e\u8457\u5f71\u54cd\u6c14\u6d41\u52a8\u529b\u5b66\u884c\u4e3a\u3002\u4e00\u822c\u8ba4\u4e3a\uff0c\u7403\u5f62\u7684\u6c14\u96fe\u7c92\u5b50\u8f83\u597d\uff0c\u5176Da \u7b49\u4e8e\u5176\u7269\u7406\u76f4\u5f84(D) \u4e58\u4ee5\u6839\u53f7\u4e0b\u7c92\u5b50\u5bc6\u5ea6(\u03c1)\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">1.2 \u9759\u7535<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u9759\u7535\u529b\u662f\u4e00\u79cd\u4e3b\u8981\u7684\u7c92\u5b50\u95f4\u4f5c\u7528\u529b\uff0c\u5f71\u54cd\u836f\u7269\u88c5\u91cf\u3001\u9012\u9001\u5242\u91cf\u5747\u4e00\u6027\u4ee5\u53ca\u80ba\u90e8\u6c89\u79ef\u91cf[9\u201410]\u3002\u9759\u7535\u4e5f\u4f1a\u9020\u6210\u7ec6\u5c0f\u836f\u7c89\u5236\u5907\u8fc7\u7a0b\u4e2d\u7684\u7c89\u672b\u9ecf\u58c1\u73b0\u8c61[11]\uff0c\u9020\u6210\u6df7\u5408\u8fc7\u7a0b\u4e2d\u7684\u836f\u7269\u635f\u5931\u3002\u540c\u65f6\uff0c\u9759\u7535\u4f5c\u7528\u4e5f\u4e0d\u603b\u662f\u6709\u5bb3\u7684\uff0c\u4f8b\u5982\u5176\u6709\u52a9\u4e8e\u5236\u5907\u5747\u5300\u5305\u8986\u7ec6\u836f\u7269\u7c92\u5b50\u7684\u7c97\u8f7d\u4f53\u9897\u7c92[12]\uff0c\u4ee5\u53ca\u901a\u8fc7\u63a7\u5236\u7c92\u5b50\u5e26\u7535\u6781\u6027\u548c\u7535\u91cf\u8fbe\u5230\u80ba\u6df1\u90e8\u9776\u5411\u7684\u76ee\u7684\u3002DPI \u7cfb\u7edf\u7684\u9759\u7535\u662f\u7531\u5176\u88c5\u7f6e\u548c\u5904\u65b9\u51b3\u5b9a\u7684\u3002\u5728\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u7531\u4e8e\u9897\u7c92\u95f4\u4ee5\u53ca\u9897\u7c92\u4e0e\u88c5\u7f6e\u95f4\u6469\u64e6\u4f1a\u4ea7\u751f\u9759\u7535\uff0c\u800c\u836f\u7c89\u4e3b\u8981\u662f\u7531\u7edd\u7f18\u7ec6\u9897\u7c92\u7ec4\u6210\uff0c\u7535\u8377\u4e0d\u6613\u6d88\u6563\uff0c\u4f7f\u7c89\u672b\u53d1\u751f\u805a\u96c6\u3001\u9ecf\u9644\uff0c\u4e0d\u540c\u7684\u836f\u7c89\u4e5f\u4f1a\u4ea7\u751f\u4e0d\u540c\u7684\u6781\u6027\u548c\u7535\u8377\u6c34\u5e73\uff0c\u8868\u9762\u7535\u8377\u7684\u4ea7\u751f\u548c\u8870\u53d8\u53d6\u51b3\u4e8e\u9897\u7c92\u8868\u9762\u7535\u963b\u7387\u3001\u8868\u9762\u7c97\u7cd9\u5ea6\u3001\u8868\u9762\u6742\u8d28\u3001\u7c92\u5b50\u5927\u5c0f\u3001\u5f62\u72b6\u7b49\u56e0\u7d20\uff0c\u5236\u5907\u5de5\u827a( \u9897\u7c92\u5de5\u7a0b\u6280\u672f) \u4ee5\u53ca\u73af\u5883\u6761\u4ef6\u5982\u76f8\u5bf9\u6e7f\u5ea6\u4e0e\u5927\u6c14\u538b\u529b\u4e5f\u6709\u5f71\u54cd[13\u201414]\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u6982\u62ec\u6765\u8bb2\uff0c\u89e3\u51b3\u9759\u7535\u5f15\u8d77\u7684\u6d41\u52a8\u6027\u7b49\u76f8\u5173\u95ee\u9898\u7684\u4e3b\u8981\u5236\u5242\u624b\u6bb5\u67092 \u79cd[15\u201416] \uff1a\u4e00\u662f\u5c06\u5c0f\u7684\u836f\u7269\u9897\u7c92\u9644\u7740\u4e8e\u5927\u7684\u8f7d\u4f53\u4e0a\uff0c\u5f62\u6210\u9ecf\u6027\u6df7\u5408\u7269(adhesive mixture\uff0c\u56fe1A)\uff0c\u7531\u4e8e\u8f7d\u4f53\u8868\u9762\u5bb9\u91cf\u7684\u9650\u5236\uff0c\u9002\u7528\u4e8e\u5fae\u514b\u7ea7\u7684\u4f4e\u5242\u91cf\u836f\u7269\uff0c\u5982Elpen \u516c\u53f8\u7684Rolenium\u00ae\uff1b\u4e8c\u662f\u4f7f\u836f\u7269\u5f62\u6210\u7403\u5f62\u677e\u6563\u805a\u96c6\u4f53(soft spherical pellet\uff0c\u56fe1B)\uff0c\u9002\u7528\u4e8e\u6beb\u514b\u7ea7\u7684\u9ad8\u5242\u91cf\u836f\u7269\uff0c\u7a33\u5b9a\u6027\u76f8\u5bf9\u8f83\u4f4e\uff0c\u5e94\u7528\u8f83\u5c11\uff0c\u5982\u963f\u65af\u5229\u5eb7\u516c\u53f8\u7684Pulmicort\u00ae\u3002\u8fd8\u6709\u4e00\u79cd\u4ecd\u5904\u4e8e\u7814\u7a76\u9636\u6bb5\u7684\u6280\u672f\u624b\u6bb5\u662f\u5c06\u7eb3\u7c73\u7c92\u5b50\u8986\u4e8e\u6d3b\u6027\u6210\u5206\u7c92\u5b50\u8868\u9762\uff0c\u4f7f\u5176\u76f8\u4e92\u95f4\u9694\u5f00\u4ee5\u51cf\u5c0f\u7c92\u5b50\u95f4\u7684\u9ecf\u7740\u884c\u4e3a[17\u201418]\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532674669.jpeg\" alt=\"\u5206\u4eab | \u5e72\u7c89\u5438\u5165\u5236\u5242\u4e2d\u7c89\u672b\u7279\u6027\u53ca\u5904\u65b9\u6a21\u5f0f\" title=\"\u5206\u4eab | \u5e72\u7c89\u5438\u5165\u5236\u5242\u4e2d\u7c89\u672b\u7279\u6027\u53ca\u5904\u65b9\u6a21\u5f0f\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">1.3 \u6c34\u5206\u542b\u91cf<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u6c34\u5206\u542b\u91cf\u53d6\u51b3\u4e8e\u7269\u6599\u672c\u8eab\u7684\u5f15\u6e7f\u6027\u4ee5\u53ca\u7c92\u5f84\u3001\u5f62\u6001\u3001\u5bc6\u5ea6\u7b49\u591a\u79cd\u56e0\u7d20\u5f71\u54cd\u7684\u5438\u6c34\u884c\u4e3a[22]\u3002\u9ad8\u76f8\u5bf9\u6e7f\u5ea6\u4f1a\u901a\u8fc7\u6bdb\u7ec6\u7ba1\u529b\u5f71\u54cd\u836f\u7269\u56e2\u805a\u53ca\u5206\u6563\uff0c\u800c\u53e6\u4e00\u65b9\u9762\uff0c\u80ba\u90e8\u7684\u76f8\u5bf9\u6e7f\u5ea6\u7ea6\u4e3a99.5\uff05\uff0c\u5177\u6709\u5f15\u6e7f\u6027\u7684\u56fa\u4f53\u9897\u7c92\u5728\u8fdb\u5165\u80ba\u90e8\u540e\uff0c\u4f1a\u5438\u6536\u6c34\u5206\u4f7f\u7c92\u5f84\u5feb\u901f\u589e\u5927\uff0c\u5f71\u54cd\u836f\u7269\u5206\u6563\uff0c\u6b64\u5916\u7c92\u5b50\u7ed3\u6676\u5f62\u6001\u4e5f\u53ef\u80fd\u6539\u53d8\u3002\u63a7\u5236\u6c34\u5206\u53ef\u4ee5\u51cf\u5c11\u6bdb\u7ec6\u7ba1\u529b\uff0c\u4f46\u53ef\u80fd\u589e\u52a0\u8868\u9762\u7535\u8377[23]\u3002\u5728\u86cb\u767d\u8d28\u7c7b\u836f\u7269\u7684\u5438\u5165\u5242\u4e2d\uff0c\u6e7f\u5ea6\u589e\u52a0\u8fd8\u4f1a\u7834\u574f\u86cb\u767d\u8d28\u7684\u5316\u5b66\u7a33\u5b9a\u6027\u3002\u52a0\u5165\u4e73\u7cd6\u53ef\u4ee5\u6539\u5584\u836f\u7269\u7684\u5206\u6563\u6027\uff0c\u4f46\u4f1a\u589e\u52a0\u5e72\u7c89\u7684\u5438\u6e7f\u6027\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">1.4 \u6d41\u52a8\u6027<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u6d41\u52a8\u6027\u662f\u7c89\u672b\u7684\u91cd\u8981\u6027\u8d28\u4e4b\u4e00\uff0c\u53cd\u6620\u5176\u9ecf\u9644\u6027\u3002\u5438\u5165\u7c89\u672b\u5fc5\u987b\u5177\u6709\u4e00\u5b9a\u7684\u6d41\u52a8\u6027\uff0c\u8fd9\u4e00\u6027\u8d28\u5bf9\u4e8e\u5de5\u827a\u8fc7\u7a0b\u3001\u7cbe\u786e\u5b9a\u91cf\u548c\u91ca\u836f\u5242\u91cf\u5747\u4e00\u6027(DDU) \u975e\u5e38\u91cd\u8981\u3002\u5f71\u54cd\u7c89\u672b\u6d41\u52a8\u6027\u7684\u539f\u56e0\u5f52\u7eb3\u8d77\u6765\u6709\u4ee5\u4e0b\u51e0\u65b9\u9762\uff1a\u2460\u5f62\u6001\u4e0d\u89c4\u5219\u7c92\u5b50\u95f4\u7684\u526a\u5207\u529b\uff1b\u2461\u7c92\u5b50\u95f4\u4f5c\u76f8\u5bf9\u8fd0\u52a8\u65f6\u4ea7\u751f\u7684\u6469\u64e6\u529b\uff1b\u2462\u7c92\u5b50\u95f4\u56e0\u6469\u64e6\u7b49\u800c\u4ea7\u751f\u7684\u9759\u7535\u8377\uff0c\u4e0d\u540c\u7535\u8377\u7684\u7c92\u5b50\u95f4\u7684\u5438\u5f15\u529b\uff1b\u2463\u7c92\u5b50\u8868\u9762\u5438\u9644\u7740\u4e00\u5c42\u6c34\uff0c\u56e0\u6b64\u6709\u8868\u9762\u5f20\u529b\u53ca\u6bdb\u7ec6\u7ba1\u5f15\u529b\uff1b\u2464\u7c92\u5b50\u95f4\u8ddd\u79bb\u8fd1\u65f6\u7684\u5206\u5b50\u95f4\u5f15\u529b( \u8303\u5fb7\u534e\u529b)\u3002\u5bf9\u7c92\u5b50\u9ecf\u9644\u6027\u7684\u5f71\u54cd\u53d6\u51b3\u4e8e\u591a\u79cd\u56e0\u7d20\uff0c\u5982\u7c92\u5b50\u8868\u9762\u7269\u7406\u5316\u5b66\u6027\u8d28\u3001\u7c92\u5b50\u63a5\u89e6\u9762\u4ee5\u53ca\u73af\u5883\u56e0\u7d20\u7b49\u3002\u5f53\u7c92\u5b50\u7684\u7c92\u5f84\u5c0f\u4e8e20 \u03bcm \u65f6\uff0c\u5176\u6d41\u52a8\u6027\u5c31\u4f1a\u5f88\u5dee\u3002\u7c92\u5f84\u5927\u81f4\u76f8\u7b49\u4f46\u5f62\u72b6\u4e0d\u540c\u7684\u7c89\u672b\u5177\u6709\u4e0d\u540c\u7684\u6d41\u901f\uff0c\u7403\u5f62\u7c92\u5b50\u56e0\u76f8\u4e92\u95f4\u7684\u63a5\u89e6\u9762\u6700\u5c0f\u800c\u6d41\u52a8\u6027\u6700\u597d\uff0c\u7247\u72b6\u6216\u679d\u72b6\u7684\u7c92\u5b50\u5177\u6709\u5927\u91cf\u7684\u5e73\u9762\u63a5\u89e6\u70b9\uff0c\u6545\u6d41\u52a8\u6027\u5dee\u3002\u8868\u793a\u7c89\u672b\u6d41\u52a8\u6027\u7684\u65b9\u6cd5\u5f88\u591a\uff0c\u5e38\u7528\u7684\u6709\u4f11\u6b62\u89d2\u548c\u6d41\u901f\u7b49\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">1.5 \u5206\u6563\u6027<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5f71\u54cd\u7c89\u672b\u5904\u65b9\u5206\u6563\u7684\u56e0\u7d20\u5f88\u591a\uff0c\u5305\u62ec\u7c92\u5f84\u3001\u5f62\u72b6\u3001\u8868\u9762\u5f62\u6001\u3001\u836f\u7269\/ \u8f7d\u4f53\u6bd4\u4f8b\u3001\u7b2c\u4e09\u7ec4\u5206\u7b49\u3002\u53ef\u4ee5\u901a\u8fc7\u9897\u7c92\u5de5\u7a0b\u6280\u672f\u5236\u5907\u7279\u5b9a\u5f62\u6001\u7684\u836f\u7269\u7c92\u5b50\uff0c\u9009\u62e9\u5177\u6709\u201c\u5149\u6ed1\u201d\u6216\u8005\u201c\u7c97\u7cd9\u201d\u8868\u9762\u7684\u8f7d\u4f53\u7c92\u5b50\u6765\u6539\u53d8\u7c92\u5b50\u95f4\u4f5c\u7528\u529b\u3002\u8f7d\u4f53\u7c92\u5b50\u8868\u9762\u6027\u8d28\u4f1a\u5f71\u54cd\u7c89\u4f53\u7684\u5206\u6563\u6027\uff0c\u8fdb\u800c\u5f71\u54cd\u5fae\u7ec6\u7c92\u5b50\u5242\u91cf\u3002\u4e00\u4e9b\u7814\u7a76\u8868\u660e\u5149\u6ed1\u4e73\u7cd6\u4f1a\u589e\u52a0\u4ece\u8f7d\u4f53\u8868\u9762\u89e3\u805a\u7684\u836f\u7269\u91cf[26]\uff0c\u4f46\u4e5f\u6709\u4e00\u4e9b\u8bd5\u9a8c\u663e\u793a\u8936\u76b1\u7684\u8868\u9762\u6709\u52a9\u4e8e\u89e3\u805a[27\u201429]\u3002\u805a\u5408\u7269\u5305\u8863\u4e5f\u88ab\u7528\u6765\u6539\u5584\u9ecf\u9644\u529b[30]\uff0c\u6765\u4ee3\u66ff\u7b2c\u4e09\u5143\u7ec4\u5206\u5982\u7ec6\u7c89\u4e73\u7cd6\u7684\u6dfb\u52a0\uff0c\u7b80\u5316DPI \u7cfb\u7edf\uff0c\u5982\u75280.01\uff05\u7684\u4e59\u70ef\u57fa\u805a\u5408\u7269( \u805a\u4e59\u70ef\u9187\/ \u805a\u4e59\u70ef\u5421\u54af\u70f7\u916e) \u55b7\u96fe\u5e72\u71e5\u5305\u8863\u7684\u5e03\u5730\u5948\u5fb7\u5fae\u7c92[ (1.83\u00b10.03) \u03bcm] \u7684DPI \u5904\u65b9\u4e0e\u5e73\u6ed1\u4e73\u7cd6\u6df7\u5408\u5236\u5907\u7684DPI\u5904\u65b9\u76f8\u6bd4\uff0c\u5728NGI \u4e2d\u6d4b\u91cf\u5f97\u5230\u7684FPF \u7531(29.1\u00b10.7)\uff05\u5347\u81f3(52.8\u00b11.0)\uff05 [31]\uff0c\u901a\u8fc7AFM \u63a2\u9488\u6d4b\u91cf\u5f97\u5230\u7684\u9ecf\u9644\u529b\u7531(410\u00b1182)nN \u964d\u81f3(241\u00b182)nN\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u7c89\u4f53\u7684\u5438\u6e7f\u4f5c\u7528\uff0c\u7c92\u5b50\u8868\u9762\u5438\u9644\u7684\u6c34\u5206\u589e\u52a0\u4e86\u7c92\u5b50\u95f4\u9ecf\u7740\u529b\uff0c\u9002\u5f53\u5e72\u71e5\u6709\u5229\u4e8e\u6539\u5584\u7c89\u672b\u5206\u6563\u6027\u3002\u56e0\u6b64\u8981\u4e25\u683c\u63a7\u5236\u6e7f\u5ea6\u6761\u4ef6\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">2 \u5e72\u7c89\u5438\u5165\u5236\u5242\u5904\u65b9\u7ec4\u6210\u5bf9\u80ba\u6c89\u79ef\u7684\u5f71\u54cd<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">2.1 \u65e0\u8f7d\u4f53\u6a21\u5f0f<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5728\u65e0\u8f7d\u4f53\u548c\u6dfb\u52a0\u8f85\u6599\u6216\u4e0d\u6dfb\u52a0\u8f85\u6599\u7684\u60c5\u51b5\u4e0b\uff0c\u836f\u7269\u5e72\u7c89\u53ef\u4ee5\u662f\u5355\u4e00\u7684\u5316\u5408\u7269\u6709\u6548\u6210\u5206\uff0c\u4e5f\u53ef\u4ee5\u662f\u51e0\u79cd\u5316\u5408\u7269\u7684\u590d\u5408\u7269\uff0c\u901a\u8fc7\u55b7\u96fe\u5e72\u71e5\u6280\u672f\u3001\u5305\u8863\u6280\u672f\u3001\u63a7\u5236\u805a\u96c6\u6280\u672f\u3001PulmoSol\u2122 \u7c89\u672b\u6280\u672f\u3001TechnoSphere\u00ae \u7c89\u672b\u6280\u672f\u3001\u591a\u5b54\u7c92\u5b50\u6280\u672f\u7b49\u5236\u5907\uff0c\u4fdd\u8bc1\u836f\u7269\u9897\u7c92\u7684\u51e0\u4f55\u5f62\u72b6\u3001\u8f83\u4f4e\u7684\u8868\u9762\u80fd\u3001\u8f83\u7a84\u7684\u7c92\u5ea6\u5206\u5e03\u8303\u56f4\uff0c\u5e76\u907f\u514d\u975e\u6676\u6001\u5316\u5408\u7269\u7684\u4ea7\u751f\uff0c\u8fd9\u5bf9\u836f\u7c89\u6df7\u5408\u7269\u548c\u5438\u5165\u88c5\u7f6e\u63d0\u51fa\u4e86\u4e25\u683c\u8981\u6c42[32]\u3002\u76ee\u524d\u5df2\u7ecf\u6709Pulmicort Turbuhaler\u3001Bricanyl Turbuhaler \u65e0\u8f7d\u4f53\u5e72\u7c89\u5438\u5165\u5242\u4e0a\u5e02\u3002\u901a\u8fc7\u63a7\u5236\u5fae\u7c92\u805a\u96c6\u6280\u672f( \u6eda\u5706) \u53ef\u4ee5\u5f62\u6210\u201c\u7403\u5f62\u677e\u6563\u805a\u96c6\u4f53\u201d\uff0c\u8fd9\u79cd\u7403\u4f53\u6709\u7ea60.5 mm \u7684\u5927\u7c92\u5f84\uff0c\u56e0\u6b64\u5177\u6709\u8f83\u597d\u7684\u6d41\u52a8\u6027\u3001\u66f4\u5c0f\u7684\u9759\u7535\u3002\u5728\u5438\u5165\u6c14\u6d41\u7684\u4f5c\u7528\u4e0b\uff0c\u5438\u5165\u88c5\u7f6eTurbuhaler\u00ae\u4e2d\u88c5\u5165\u7684\u201c\u7403\u5f62\u677e\u6563\u805a\u96c6\u4f53\u201d\u4f1a\u5206\u89e3\u4e3a\u805a\u96c6\u524d\u7684\u5355\u4e2a\u7c92\u5b50\uff0c\u8fbe\u5230\u589e\u5f3a\u80ba\u6c89\u79ef\u7684\u76ee\u7684\u3002\u8fd9\u79cd\u7cfb\u7edf\u5df2\u88ab\u62a5\u9053\u7684\u7f3a\u70b9\u4e3b\u8981\u662f\u9012\u9001\u5242\u91cf\u7684\u9ad8\u5ea6\u53d8\u5f02\u6027\uff0c\u76f8\u5bf9\u6807\u51c6\u504f\u5dee\u9ad8\u8fbe15\uff05 [33]\uff0c\u4e14\u5176\u4e34\u5e8a\u6709\u6548\u6027\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u9a8c\u8bc1[34\u201435]\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">2.2 \u836f\u7269- \u8f7d\u4f53\u6a21\u5f0f(drug-carrier)<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u7c92\u5f84\u8303\u56f4\u57285 \u03bcm \u4ee5\u4e0b\u7684\u5438\u5165\u5242\u7c89\u672b\u5177\u6709\u8f83\u9ad8\u7684\u8868\u9762\u81ea\u7531\u80fd\uff0c\u6781\u6613\u805a\u96c6\u6210\u56e2\uff0c\u4f7f\u5f97\u836f\u7269\u7684\u586b\u88c5\u548c\u5206\u5242\u91cf\u96be\u4ee5\u7cbe\u786e\u64cd\u4f5c\u3002\u6700\u5e38\u7528\u7684\u89e3\u51b3\u65b9\u6cd5\u662f\u52a0\u5165\u4e00\u4e9b\u7c92\u5f84\u8f83\u5927(50 \uff5e 300 mm) \u4e14\u8868\u9762\u7c97\u7cd9\u7684\u9897\u7c92\u4f5c\u4e3a\u8f7d\u4f53\uff0c\u4f7f\u836f\u7269\u5fae\u7c89\u5438\u9644\u4e8e\u8f7d\u4f53\u88c2\u7f1d\u548c\u9ad8\u80fd\u7ed3\u5408\u4f4d\u70b9\u3002\u7528\u836f\u65f6\uff0c\u836f\u7269\u8f7d\u4f53\u590d\u5408\u7269\u501f\u52a9\u5438\u6c14\u6c14\u6d41\u8fdb\u5165\u4e0a\u547c\u5438\u9053\uff0c\u968f\u7740\u547c\u5438\u9053\u53d8\u7a84\u3001\u6c14\u6d41\u901f\u5ea6\u52a0\u5feb\uff0c\u836f\u7269\u4e0e\u8f7d\u4f53\u5206\u79bb\uff0c\u800c\u540e\u836f\u7269\u7ee7\u7eed\u5728\u9ad8\u6c14\u6d41\u4f5c\u7528\u4e0b\u8fdb\u5165\u4eba\u4f53\u80ba\u90e8\uff0c\u8f7d\u4f53\u7559\u5728\u53e3\u8154\u3002\u836f\u7269\u548c\u8f7d\u4f53\u8981\u7d27\u5bc6\u7ed3\u5408\u4ee5\u6ee1\u8db3\u6df7\u5408\u5747\u5300\u7684\u9700\u8981\uff0c\u53c8\u8981\u76f8\u5bf9\u84ec\u677e\u8fbe\u5230\u5438\u5165\u65f6\u89e3\u805a\u7684\u8981\u6c42\uff0c\u4ee5\u5b9e\u73b0\u91ca\u653e\u836f\u7269\u7684\u76ee\u7684\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">2.3 \u836f\u7269- \u8f7d\u4f53- \u6dfb\u52a0\u5242\u6a21\u5f0f(drug-carrier-additive)<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5728\u836f\u7269- \u8f7d\u4f53\u7cfb\u7edf\u4e2d\uff0c\u9664\u542b\u836f\u7ec6\u7c89\u4e0e\u8f7d\u4f53\u4e4b\u5916\uff0c\u8fd8\u53ef\u4ee5\u52a0\u5165\u53e6\u4e00\u79cd\u5c0f\u7c92\u5f84\u7684\u7ec4\u5206\u4ee5\u63d0\u9ad8\u836f\u7269\u80ba\u6c89\u79ef\u6027\u80fd\uff0c\u540e\u8005\u79f0\u4e3a\u7b2c\u4e09\u7ec4\u5206(ternary component)\u3002\u7b2c\u4e09\u7ec4\u5206( \u5982\u4e73\u7cd6\u3001\u7518\u9732\u9187\u3001\u78f7\u8102\u3001\u4eae\u6c28\u9178\u3001\u786c\u8102\u9178\u9541\u3001\u805a\u4e59\u4e8c\u91876000 \u7b49) \u53ef\u4ee5\u662f\u4e0e\u8f7d\u4f53\u4e0d\u540c\u7684\u6dfb\u52a0\u5242\uff0c\u4e5f\u53ef\u4ee5\u662f\u8ddf\u8f7d\u4f53\u6210\u5206\u4e00\u6837\u7684\u7ec6\u7c89\uff0c\u5728\u8fd110 \u5e74\u5185\u88ab\u5e7f\u6cdb\u7814\u7a76\uff0c\u5176\u4f5c\u7528\u662f\u4e0e\u836f\u7269\u7ade\u4e89\u5438\u9644\u4e8e\u8f7d\u4f53\u7684\u9ad8\u80fd\u90e8\u4f4d( \u5982\u51f9\u51f8\u6216\u7f1d\u9699\u5904) \u6216\u6d88\u9664 DPI \u4f7f\u7528\u65f6\u56e0\u6469\u64e6\u800c\u4ea7\u751f\u7684\u9759\u7535\u529b\uff0c\u4ece\u800c\u51cf\u5f31\u836f\u7269\u4e0e\u8f7d\u4f53\u7684\u5438\u9644\u4f5c\u7528\u3002\u56e0\u6b64\u836f\u7269\u3001\u8f7d\u4f53\u548c\u7b2c\u4e09\u7ec4\u5206\u7684\u52a0\u5165\u6bd4\u4f8b\u4ee5\u53ca\u6df7\u5408\u987a\u5e8f\u5341\u5206\u5173\u952e[45]\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">3 \u7ed3\u8bed<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u5bf9\u4e8e\u57fa\u4e8e\u8f7d\u4f53\u7684\u6df7\u5408\u7269\uff0c\u5fc5\u987b\u5728\u8d2e\u5b58\u548c\u5904\u7406\u8fc7\u7a0b\u4e2d\u7684\u6df7\u5408\u7a33\u5b9a\u6027\u4e0e\u5438\u5165\u5206\u6563\u8fc7\u7a0b\u4e2d\u53d6\u5f97\u5e73\u8861\uff0c\u8fd9\u5c31\u8981\u6c42\u63a7\u5236\u7c92\u5b50\u95f4\u4f5c\u7528\u529b\u3002de Boer \u7b49\u6307\u51fa\uff0c\u4e0e\u8fd9\u4e9b\u8fc7\u7a0b\u76f8\u5173\u7684\u53d8\u91cf\u4f1a\u4ee5\u4e0d\u540c\u7684\u65b9\u5f0f\u5f71\u54cd\u5f7c\u6b64\uff0c\u901a\u8fc7\u6539\u53d8\u5176\u4e2d\u4e00\u4e2a\u53d8\u91cf\uff0c\u5176\u4ed6\u53d8\u91cf\u5f71\u54cd\u7684\u7ed3\u679c\u5c31\u53ef\u80fd\u9006\u8f6c[49]\uff0c\u8fd9\u4e5f\u53ef\u4ee5\u89e3\u91ca\u4e3a\u4ec0\u4e48\u4e00\u4e9b\u5173\u4e8e\u5355\u4e2a\u53d8\u91cf\u5f71\u54cd\u7684\u6587\u732e\u5f97\u51fa\u76f8\u53cd\u7ed3\u8bba\u7684\u73b0\u8c61\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u7ed9\u836f\u9014\u5f84\uff0cDPI \u5177\u6709\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u65b0DPI \u4ea7\u54c1\u6b63\u8fdb\u5165\u5e02\u573a\u3002DPI\u4e2d\u7c89\u672b\u7684\u5927\u5c0f\u3001\u5f62\u8c8c\u3001\u6d41\u52a8\u6027\u3001\u7535\u6027\u3001\u5206\u6563\u6027\u548c\u5438\u6e7f\u6027\u7b49\u4f1a\u5bf9\u6574\u4e2a\u7c89\u672b\u6027\u8d28\u6709\u4e00\u5b9a\u7684\u5f71\u54cd\uff0c\u8fd9\u4e9b\u6027\u8d28\u7684\u7814\u7a76\u5bf9\u5b9e\u9645\u5e94\u7528\u4e5f\u6709\u8f83\u4e3a\u91cd\u8981\u7684\u6307\u5bfc\u610f\u4e49\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word 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