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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\u963f\u65af\u5229\u5eb7\uff08AstraZeneca\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u5176\u9488\u5bf9\u7cd6\u5c3f\u75c5\u7684\u65b0\u836fFarxiga\uff08dapagliflozin\uff0c\u8fbe\u683c\u5217\u51c0\uff09\u5728\u5fc3\u8840\u7ba1\u75be\u75c5\uff08CV\uff09\u9886\u57df\u76843\u671f\u8bd5\u9a8cDECLARE-TIMI 58\u4e2d\u83b7\u5f97\u4e86\u663e\u8457\u79ef\u6781\u7ed3\u679c\u3002<\/strong>\u8be5\u8bd5\u9a8c\u4e3a\u5927\u578b\u5b89\u6170\u5242\u5bf9\u71673\u671f\u8bd5\u9a8c\uff0c\u5305\u542b1\u4e077\u5343\u540d2\u578b\u7cd6\u5c3f\u75c5\uff08T2D\uff09\u60a3\u8005\u3002\u8bd5\u9a8c\u4ee5\u663e\u8457\u826f\u597d\u7684\u6570\u636e\u8fbe\u5230\u4e86\u5176\u4e3b\u8981\u590d\u5408\u7ec8\u70b9\u3002\u9664\u6b64\u4e4b\u5916\uff0cFarxiga\u826f\u597d\u7684\u5b89\u5168\u6027\u4e5f\u518d\u6b21\u5f97\u5230\u4e86\u8bc1\u5b9e\u3002\u8be5\u8bd5\u9a8c\u7684\u8be6\u7ec6\u6570\u636e\u5c06\u4e8e2018\u5e7411\u670810\u65e5\u5728\u829d\u52a0\u54e5\u4e3e\u529e\u7684\u7f8e\u56fd\u5fc3\u810f\u534f\u4f1a\u5e74\u5ea6\u79d1\u5b66\u4f1a\u8bae\u4e0a\u53d1\u8868\u3002<\/span><\/p>\n

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\"\u901f\u9012<\/p>\n

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<\/p>\n

Farxiga\u662f\u4e00\u6b3e\u521b\u65b0\u578b\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684\u4eba\u6e90\u94a0-\u8461\u8404\u7cd6\u5171\u8f6c\u8fd0\u86cb\u767d2\u578b\uff08SGLT2\uff09\u9009\u62e9\u6027\u6291\u5236\u5242\u3002<\/span><\/strong>\u8be5\u836f\u5e76\u4e0d\u80fd\u5355\u72ec\u6cbb\u7597\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u6216\u5fc3\u529b\u8870\u7aed\uff0c\u4f46\u53ef\u4ee5\u4f5c\u4e3a\u5355\u836f\u6216\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u5408\u4f7f\u7528\u5bf9T2D\u60a3\u8005\u8fdb\u884c\u8840\u7cd6\u63a7\u5236\u3002\u8be5\u836f\u8fd8\u53ef\u4ee5\u4f5c\u4e3aT2D\u6210\u4eba\u60a3\u8005\u914d\u5408\u996e\u98df\u63a7\u5236\u548c\u8fd0\u52a8\u7684\u8f85\u52a9\u6cbb\u7597\u624b\u6bb5\uff0c\u5e2e\u52a9\u60a3\u8005\u51cf\u8f7b\u4f53\u91cd\u548c\u964d\u4f4e\u8840\u538b\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8be5\u836f\u5df2\u5b8c\u6210\u4e86\u8d85\u8fc735\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u83b7\u5f97\u4e86\u575a\u5b9e\u7684\u8bd5\u9a8c\u6570\u636e\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u76842b\u671f\u53ca3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5305\u542b\u8d85\u8fc73\u4e075\u5343\u540d\u60a3\u8005\uff0c\u5e76\u6709\u8d85\u8fc7180\u4e07\u4e2a\u75c5\u4eba\u5e74\uff08patient-years\uff09\u7684\u6570\u636e\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

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\u672c\u6b21\u516c\u5e03\u7ed3\u679c\u7684DECLARE-TIMI 58\u662f\u4e00\u9879\u968f\u673a\u53cc\u76f2\u5b89\u6170\u5242\u5bf9\u7167\u591a\u4e2d\u5fc3\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65f6\u95f4\u8de8\u5ea6\u957f\u8fbe\u4e94\u5e74\uff0c\u5305\u542b\u6765\u81ea33\u4e2a\u56fd\u5bb6882\u4e2a\u4e2d\u5fc3\u7684\u8d85\u8fc71\u4e077\u5343\u540d\u53d7\u591a\u79cd\u5fc3\u8840\u7ba1\u75be\u75c5\u5f71\u54cd\u7684T2D\u60a3\u8005\u3002\u8bd5\u9a8c\u65e8\u5728\u8bc4\u4f30Farxiga\u5728\u5fc3\u8840\u7ba1\u75be\u75c5\u65b9\u9762\u5bf9\u6bd4\u5b89\u6170\u5242\u7684\u7597\u6548\u3002\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0cFarxiga\u8fbe\u5230\u4e86\u4e3b\u8981\u4e0d\u826f\u5fc3\u8840\u7ba1\u4e8b\u4ef6\uff08MACE\uff09\u7684\u975e\u52a3\u6548\u6027\u4e3b\u8981\u5b89\u5168\u6027\u7ec8\u70b9\uff0c\u4e5f\u8fbe\u5230\u4e86\u663e\u8457\u51cf\u5c11\u56e0\u5fc3\u529b\u8870\u7aed\uff08hHF\uff09\u800c\u9700\u5165\u9662\u6cbb\u7597\u7684\u6982\u7387\u6216\u5fc3\u8840\u7ba1\u6b7b\u4ea1\uff08CV death\uff09\u6982\u7387\u7684\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u3002<\/strong><\/span><\/p>\n

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\u963f\u65af\u5229\u5eb7\u5168\u7403\u533b\u836f\u53d1\u5c55\u90e8\uff0c\u80be\u810f\u53ca\u65b0\u9648\u4ee3\u8c22\u5206\u652f\uff0c\u5fc3\u8840\u7ba1\u4e2d\u5fc3\u526f\u603b\u88c1Elisabeth Bj\u00f6rk\u535a\u58eb\u8bf4\uff1a\u201cFarxiga\u663e\u8457\u826f\u597d\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u8bc1\u5b9e\u4e86\u8be5\u836f\u53ef\u4ee5\u666e\u904d\u5927\u5e45\u51cf\u5c11T2D\u60a3\u8005\u56e0\u5fc3\u529b\u8870\u7aed\u800c\u9700\u5165\u9662\u6cbb\u7597\u7684\u6982\u7387\u6216\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u6982\u7387\u3002\u8fd9\u4e00\u8bd5\u9a8c\u5177\u6709\u91cc\u7a0b\u7891\u5f0f\u7684\u610f\u4e49\uff0c\u56e0\u4e3a\u5fc3\u529b\u8870\u7aed\u662f\u7cd6\u5c3f\u75c5\u7684\u4e00\u79cd\u65e9\u671f\u5e38\u89c1\u5e76\u53d1\u75c7\uff0c\u4f1a\u5bfc\u81f4\u5927\u91cf\u60a3\u8005\u9700\u8981\u5165\u9662\u6cbb\u7597\uff0c\u4ece\u591a\u4e2a\u65b9\u9762\u7ed9\u793e\u4f1a\u548c\u7ecf\u6d4e\u5e26\u6765\u6781\u5927\u7684\u8d1f\u62c5\u3002\u201d<\/span><\/p>\n

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\u6211\u4eec\u795d\u8d3a\u963f\u65af\u5229\u5eb7\u7684Farxiga\u518d\u6b21\u83b7\u5f97\u826f\u597d\u575a\u5b9e\u7684\u8bd5\u9a8c\u6570\u636e\uff0c\u5e76\u671f\u5f85\u8fd9\u6b3e\u65b0\u836f\u53ef\u4ee5\u65e9\u65e5\u4e3a\u60a3\u6709\u5fc3\u8840\u7ba1\u75be\u75c5\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u964d\u4f4e\u75be\u75c5\u5e26\u6765\u7684\u5371\u9669\u3002<\/span><\/p>\n

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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] Farxiga achieved a positive result in the Phase III DECLARE-TIMI 58 trial, a large cardiovascular outcomes trial in 17,000 patients with type-2 diabetes. Retrieved September 24, 2018, from https:\/\/www.astrazeneca.com\/content\/astraz\/media-centre\/press-releases\/2018\/farxiga-achieved-a-positive-result-in-the-phase-iii-declare-timi-58-trial-a-large-cardiovascular-outcomes-trial-in-17000-patients-with-type-2-diabetes-24092018.html<\/span><\/p>\n

[2] Diabetes mellitus type 2 – Wikipedia. Retrieved September 24, 2018, from https:\/\/en.wikipedia.org\/wiki\/Diabetes_mellitus_type_2<\/span><\/p>\n

[3] \u963f\u65af\u5229\u5eb7\u516c\u5e032\u578b\u7cd6\u5c3f\u75c5\u65b0\u836f3\u671f\u4e34\u5e8a\u79ef\u6781\u7ed3\u679c. Retrieved September 24, 2018, from https:\/\/mp.weixin.qq.com\/s\/5Vv6Qq3Smx5vAuGCI_adgw<\/span><\/p>\n

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