{"id":49002,"date":"2018-09-25T01:00:00","date_gmt":"2018-09-26T01:54:01","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e9%80%9f%e9%80%92-%e6%85%a2%e6%80%a7%e8%82%be%e7%97%85%e6%82%a3%e8%80%85%e7%a6%8f%e9%9f%b3%ef%bc%81%e6%96%b0%e8%8d%af3%e6%9c%9f%e4%b8%b4%e5%ba%8a%e5%8f%96%e5%be%97%e7%a7%af%e6%9e%81%e6%88%90\/"},"modified":"2018-09-26T09:54:02","modified_gmt":"2018-09-26T01:54:02","slug":"%e9%80%9f%e9%80%92-%e6%85%a2%e6%80%a7%e8%82%be%e7%97%85%e6%82%a3%e8%80%85%e7%a6%8f%e9%9f%b3%ef%bc%81%e6%96%b0%e8%8d%af3%e6%9c%9f%e4%b8%b4%e5%ba%8a%e5%8f%96%e5%be%97%e7%a7%af%e6%9e%81%e6%88%90","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/49002\/","title":{"rendered":"\u901f\u9012 | \u6162\u6027\u80be\u75c5\u60a3\u8005\u798f\u97f3\uff01\u65b0\u836f3\u671f\u4e34\u5e8a\u53d6\u5f97\u79ef\u6781\u6210\u679c"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\u5b89\u65af\u6cf0\u6765\uff08Astellas Pharma\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5176\u9488\u5bf9\u8d2b\u8840\u6027\u6162\u6027\u80be\u75c5\uff08CKD\uff09\u60a3\u8005\u7684\u65b0\u836froxadustat\uff08ASP1517 \/ FG-4592\uff09\uff0c\u5728\u5168\u7403\u8303\u56f43\u671f\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8cALPS\u4e2d\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\u3002<\/strong>\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0croxadustat\u663e\u793a\u51fa\u4e86\u8fdc\u8d85\u4e8e\u5b89\u6170\u5242\u7684\u826f\u597d\u7597\u6548\u3002\u521d\u6b65\u5b89\u5168\u6027\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0croxadustat\u6574\u4f53\u5b89\u5168\u6027\u4e0e\u4e4b\u524d\u9488\u5bf9\u8d2b\u8840\u6027CKD\u7684\u8bd5\u9a8c\u7ed3\u679c\u4fdd\u6301\u4e00\u81f4\u3002<\/span><\/p>\n

\"\u901f\u9012<\/span><\/p>\n

CKD\uff08\u53c8\u79f0\u6162\u6027\u80be\u529f\u80fd\u4e0d\u5168\u6216\u6162\u6027\u80be\u8870\u7aed\uff09\u662f\u4e00\u79cd\u80be\u529f\u80fd\u5728\u51e0\u4e2a\u6708\u6216\u82e5\u5e72\u5e74\u671f\u95f4\u53d1\u751f\u96be\u4ee5\u9006\u8f6c\u8870\u9000\u7684\u75be\u75c5\u3002\u636e\u4f30\u8ba1\u5168\u7403\u6709\u8d85\u8fc7\u4e24\u4ebf\u7684CKD\u60a3\u8005<\/strong>\uff0c\u5728\u7f8e\u56fd\u7ea6\u670913%\u7684\u6210\u4eba\u60a3\u6709\u8be5\u75be\u75c5\uff0c\u4f46\u5927\u591a\u6570\u60a3\u8005\u5bf9\u81ea\u8eab\u75c5\u60c5\u5f80\u5f80\u5e76\u4e0d\u81ea\u77e5\u3002CKD\u53ef\u80fd\u5728\u4efb\u4f55\u5e74\u9f84\u53d1\u751f\uff0c\u4e14\u60a3\u75c5\u7387\u968f\u5e74\u9f84\u589e\u957f\u663e\u8457\u589e\u52a0\uff0c\u56e0\u6b64\u5728\u8001\u5e74\u4eba\u7fa4\u4e2d\u66f4\u52a0\u666e\u904d\u3002\u8d2b\u8840\u662fCKD\u7684\u5e38\u89c1\u5e76\u53d1\u75c7\uff0c\u4e0e\u900f\u6790\u548c\u975e\u900f\u6790\u4eba\u7fa4\u7684\u4e25\u91cd\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u6709\u5173\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u9664\u4e86\u80be\u79fb\u690d\u4ee5\u5916\uff0c\u5e76\u6ca1\u6709\u963b\u6b62CKD\u60a3\u8005\u80be\u529f\u80fd\u6076\u5316\u7684\u6709\u6548\u7597\u6cd5\uff0c\u56e0\u6b64\u8be5\u9886\u57df\u7684\u533b\u7597\u9700\u6c42\u975e\u5e38\u5927\uff0c\u4e14\u65e5\u76ca\u589e\u957f\u3002<\/strong><\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

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\u25b2<\/span>Roxadustat\u7684\u5206\u5b50\u7ed3\u6784\u5f0f\uff08\u56fe\u7247\u6765\u6e90\uff1aBy Meodipt [Public domain or Public domain], from Wikimedia Commons\uff09<\/span><\/strong><\/p>\n


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Roxadustat\u662f\u4e00\u6b3e\u9762\u5411\u900f\u6790\u548c\u975e\u900f\u6790\u8d2b\u8840\u6027CKD\u60a3\u8005\u7684\u6df7\u5408\u53e3\u670d\u5c0f\u5206\u5b50\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff08HIF\uff09\u812f\u6c28\u9170\u7f9f\u5316\u9176\u6291\u5236\u5242<\/span><\/strong>\uff0c\u7531\u5b89\u65af\u6cf0\u6765\u7684\u5408\u4f5c\u4f19\u4f34FibroGen\u53d1\u73b0\u5e76\u5f00\u53d1\u3002HIF\u662f\u4e00\u79cd\u86cb\u767d\u8d28\u8f6c\u5f55\u56e0\u5b50\uff0c\u80fd\u8bf1\u5bfc\u4f4e\u6c27\u6761\u4ef6\u7684\u81ea\u7136\u751f\u7406\u53cd\u5e94\uff0c\u5f00\u542f\u7ea2\u7ec6\u80de\u751f\u6210\u548c\u5176\u4ed6\u4fdd\u62a4\u9014\u5f84\u3002<\/span><\/p>\n


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\u8fd9\u6b21\u516c\u5e03\u7ed3\u679c\u7684ALPS\u8bd5\u9a8c\u662f\u5b89\u65af\u6cf0\u6765EMEA\uff08\u6b27\u6d32\u3001\u4e2d\u4e1c\u53ca\u975e\u6d32\uff09\u4e2d\u5fc3\u8fdb\u884c\u76843\u98793\u671f\u8bd5\u9a8c\u4e2d\u9996\u4e2a\u63d0\u4ea4\u62a5\u544a\u7ed3\u679c\u7684\u8bd5\u9a8c\u3002\u8be5\u5168\u7403\u8303\u56f4\u5927\u89c4\u6a213\u671f\u8bd5\u9a8c\u7531\u5b89\u65af\u6cf0\u6765\u4e0eFibroGen\u5171\u540c\u5b8c\u6210\u3002ALPS\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u968f\u673a\u53cc\u76f2\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\uff0c\u4e3a\u671f52-104\u5468\uff0c\u65e8\u5728\u8bc4\u4f30roxadustat\u9488\u5bf9\u975e\u900f\u6790\u8d2b\u8840\u6027CKD\u60a3\u8005\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u3002\u8bd5\u9a8c\u9762\u5411\u975e\u900f\u6790\u8d2b\u8840\u6027CKD\u60a3\u8005\uff08\u5e73\u5747Hb \u2264 10 g\/dL\uff09\uff0c\u5176\u4e2d\u4e09\u5206\u4e4b\u4e8c\u968f\u673a\u5206\u914d\u81f3roxadustat\u7ec4\uff0c\u53e6\u4e09\u5206\u4e4b\u4e00\u968f\u673a\u5206\u914d\u81f3\u5b89\u6170\u5242\u7ec4\u3002\u8be5\u8bd5\u9a8c\u6709\u4e24\u4e2a\u4e3b\u8981\u7ec8\u70b9\uff0c\u5305\u62ec\u524d24\u5468\u7684Hb\u53cd\u5e94\u7387\uff08\u4ec5\u5305\u542b\u7f8e\u56fd\u60a3\u8005\uff09\u548c28-52\u5468Hb\u8f83\u57fa\u7ebf\u53d8\u5316\u5747\u6570\uff08\u4ec5\u5305\u542b\u6b27\u6d32\u53ca\u4e2d\u4e1c\u60a3\u8005\uff09\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0croxadustat\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\uff0c\u4e14\u8010\u53d7\u6027\u4e0e\u5b89\u5168\u6027\u5747\u4e3a\u826f\u597d\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

\u25b2<\/span><\/span><\/strong>\u5b89\u65af\u6cf0\u6765\u516c\u53f8\u8d44\u6df1\u526f\u603b\u88c1\u517c\u533b\u5b66\u7814\u53d1\u5168\u7403\u533b\u7597\u4e3b\u7ba1Salim Mujais\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1a\u5b89\u65af\u6cf0\u6765\u5b98\u7f51\uff09<\/span><\/strong><\/p>\n


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\u201cALPS\u8bd5\u9a8c\u83b7\u5f97\u7684\u7ed3\u679c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86roxadustat\u4f5c\u4e3a\u8d2b\u8840\u6027CKD\u7597\u6cd5\u5177\u6709\u7684\u6781\u5927\u6f5c\u529b\uff0c\u201d\u5b89\u65af\u6cf0\u6765\u516c\u53f8\u8d44\u6df1\u526f\u603b\u88c1\u517c\u533b\u5b66\u7814\u53d1\u5168\u7403\u533b\u7597\u4e3b\u7ba1Salim Mujais\u535a\u58eb\u8bf4\uff1a\u201c\u6211\u4eec\u671f\u5f85\u7ee7\u7eed\u5b8c\u5584\u8be5\u7597\u6cd5\uff0c\u4e89\u53d6\u65e9\u65e5\u4e3a\u6df1\u53d7\u8d2b\u8840\u6027CKD\u6298\u78e8\u7684\u60a3\u8005\u5e26\u6765\u4e00\u4e2a\u65b0\u7684\u6cbb\u7597\u9009\u9879\u3002\u201d<\/span><\/p>\n


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\u6211\u4eec\u795d\u8d3a\u5b89\u65af\u6cf0\u6765\u4e0eFibroGen\u6b64\u6b21\u83b7\u5f97\u7684\u79ef\u6781\u8bd5\u9a8c\u7ed3\u679c\uff0c\u5e76\u671f\u5f85\u8be5\u836f\u53ef\u4ee5\u8fdb\u4e00\u6b65\u5f97\u5230\u5b8c\u5584\uff0c\u4e3a\u5e7f\u5927\u60a3\u8005\u4eec\u5e26\u6765\u798f\u97f3\u3002<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] Astellas Announces Positive Topline Results for Global Phase 3 Trial of Roxadustat in Chronic Kidney Disease (CKD) Patients with Anemia <\/span>not<\/span> on Dialysis. Retrieved September 21, 2018, from https:\/\/www.astellas.com\/en\/news\/14261<\/span><\/p>\n

[2] \u9020\u798f2\u4ebf\u60a3\u8005\uff0c\u80be\u75c5\u65b0\u836f3\u671f\u4e34\u5e8a\u6570\u636e\u4f18\u79c0. Retrieved September 21, 2018, from https:\/\/mp.weixin.qq.com\/s\/cAIn08jrthjt3av7r4P54g<\/span><\/p>\n

[3] CKD – Wikipedia. Retrieved September 21, 2018, from https:\/\/en.wikipedia.org\/wiki\/Chronic_kidney_disease<\/span><\/p>\n


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\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


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\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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