{"id":49008,"date":"2018-09-25T01:00:00","date_gmt":"2018-09-26T01:54:04","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e9%80%9f%e9%80%92-%e6%ad%a6%e7%94%b0%e8%be%be%e6%88%90%e5%90%88%e4%bd%9c%e5%8d%8f%e8%ae%ae%ef%bc%8c%e9%92%88%e5%af%b9cd38%e5%bc%80%e5%8f%91%e6%96%b0%e7%96%97%e6%b3%95\/"},"modified":"2018-09-26T09:54:05","modified_gmt":"2018-09-26T01:54:05","slug":"%e9%80%9f%e9%80%92-%e6%ad%a6%e7%94%b0%e8%be%be%e6%88%90%e5%90%88%e4%bd%9c%e5%8d%8f%e8%ae%ae%ef%bc%8c%e9%92%88%e5%af%b9cd38%e5%bc%80%e5%8f%91%e6%96%b0%e7%96%97%e6%b3%95","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/49008\/","title":{"rendered":"\u901f\u9012 | \u6b66\u7530\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u9488\u5bf9CD38\u5f00\u53d1\u65b0\u7597\u6cd5"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<h1  style=\"margin-bottom: 0.8em;font-weight: inherit;font-size: 1.7em;white-space: normal;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4f4d\u4e8e\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u5dde\u5967\u65af\u6c40\u5e02\u7684\u751f\u7269\u6280\u672f\u516c\u53f8<strong>Molecular Templates\u8fd1\u65e5\u5ba3\u5e03\u4e0e\u6b66\u7530\uff08Takeda\uff09\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u5c06\u5171\u540c\u7814\u53d1\u9776\u5411\u7cd6\u86cb\u767dCD38\u7684\u5de5\u7a0b\u5316\u6bd2\u7d20\u4f53\uff08Engineered Toxin Bodies\uff0cETBs\uff09\uff0c\u4ee5\u671f\u5e94\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08Multiple Myeloma\uff09\u5728\u5185\u7684\u591a\u79cd\u75be\u75c5<\/strong>\u3002\u5728\u524d\u671f\u5408\u4f5c\u4e2d\uff0c\u4e24\u5bb6\u516c\u53f8\u5df2\u5b8c\u6210\u9776\u5411CD38\u7684\u591a\u4e2aETBs\u7684\u4e34\u5e8a\u524d\u7814\u53d1\u8fdb\u7a0b\uff0c\u5e76\u53d6\u5176\u4e2d\u4e4b\u4e00\u4f5c\u4e3a\u4e3b\u8981\u7814\u53d1\u5019\u9009\u836f\u7269\u3002\u6b64\u6b21\u5408\u4f5c\u534f\u8bae\u7684\u8fbe\u6210\u5c06\u63a8\u8fdb\u4e24\u5bb6\u516c\u53f8\u8fdb\u4e00\u6b65\u7814\u53d1\u9488\u5bf9\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u65b0\u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537926845.jpg\" alt=\"\u901f\u9012 | \u6b66\u7530\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u9488\u5bf9CD38\u5f00\u53d1\u65b0\u7597\u6cd5\" title=\"\u901f\u9012 | \u6b66\u7530\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u9488\u5bf9CD38\u5f00\u53d1\u65b0\u7597\u6cd5\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u662f\u4e00\u79cd\u7531\u4e8e\u6d46\u7ec6\u80de\uff08\u4e00\u79cd\u4e13\u95e8\u8d1f\u8d23\u5236\u9020\u6297\u4f53\u7684\u767d\u8840\u7403\u7ec6\u80de\uff09\u4e0d\u6b63\u5e38\u589e\u751f\u800c\u5bfc\u81f4\u7684\u9aa8\u9ad3\u6076\u6027\u80bf\u7624\u3002<strong>\u5b83\u521d\u671f\u5e76\u65e0\u75c7\u72b6\u4ea7\u751f\uff0c\u76f4\u5230\u75c5\u60c5\u52a0\u91cd\u624d\u4f1a\u6709\u9aa8\u75db\u3001\u7ecf\u5e38\u6027\u611f\u67d3\u548c\u8d2b\u8840\u7b49\u7684\u75c7\u72b6\uff0c\u4e14\u76ee\u524d\u81f4\u75c5\u539f\u56e0\u4e0d\u660e\u3002<\/strong>2015\u5e74\u5168\u7403\u7ea6\u670949\u4e07\u540d\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u3002\u5728\u7f8e\u56fd\uff0c\u6bcf10\u4e07\u4eba\u4e2d\u53ef\u80fd\u51fa\u73b06.5\u4f8b\u60a3\u8005\uff0c\u67090.7%\u7684\u4eba\u5728\u5176\u4e00\u751f\u4e2d\u4f1a\u6709\u67d0\u4e2a\u65f6\u95f4\u70b9\u7f79\u60a3\u6b64\u75be\u75c5\u3002\u82e5\u65e0\u6cbb\u7597\uff0c\u5176\u9884\u671f\u751f\u5b58\u65f6\u95f4\u7ea6\u4e3a\u4e03\u4e2a\u6708\u3002\u82e5\u8fdb\u884c\u6cbb\u7597\uff0c\u5219\u53ef\u751f\u5b584\u81f35\u5e74\u3002<strong>\u8be5\u75be\u75c5\u7684\u4e94\u5e74\u751f\u5b58\u7387\u7ea6\u4e3a49%\u3002<\/strong>\u56e0\u6b64\uff0c\u60a3\u8005\u4eec\u6025\u9700\u4e00\u6b3e\u521b\u65b0\u578b\u7597\u6cd5\u6765\u5e2e\u52a9\u4ed6\u4eec\u964d\u4f4e\u75be\u75c5\u5e26\u6765\u7684\u5371\u9669\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">CD38\u662f\u4e00\u79cd\u5728\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7ec6\u80de\u4e2d\u9ad8\u5ea6\u8868\u8fbe\u7684\u8868\u9762\u7cd6\u86cb\u767d\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u56e0\u6b64\uff0c\u9776\u5411CD38\u6210\u4e3a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7597\u6cd5\u7814\u53d1\u4e2d\u81f3\u5173\u91cd\u8981\u7684\u4e00\u73af\u3002\u9776\u5411CD38\u7684ETBs\u53ef\u4ee5\u8bc6\u522b\u8be5\u86cb\u767d\uff0c\u5e76\u5c06\u4e00\u79cd\u4fee\u9970\u8fc7\u7684\u7ec6\u83cc\u6027\u6bd2\u7d20\u4f20\u9001\u8fdb\u9aa8\u9ad3\u7624\u7ec6\u80de\uff0c\u4fc3\u8fdb\u6838\u7cd6\u4f53\u7684\u4e0d\u53ef\u9006\u7834\u574f\uff0c\u6700\u7ec8\u5c06\u80bf\u7624\u7ec6\u80de\u6740\u6b7b\u3002\u4e0e\u5176\u4ed6\u9776\u5411CD38\u7684\u7597\u6cd5\u4e0d\u540c\uff0cETBs\u7684\u4f5c\u7528\u5e76\u4e0d\u4f9d\u8d56\u4e8e\u8eab\u4f53\u514d\u75ab\u7cfb\u7edf\uff0c\u4f7f\u5176\u53ef\u4ee5\u5177\u6709\u66f4\u5e7f\u6cdb\u7684\u6f5c\u529b\u548c\u66f4\u6df1\u5165\u7684\u7597\u6548\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537926845.jpg\" alt=\"\u901f\u9012 | \u6b66\u7530\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u9488\u5bf9CD38\u5f00\u53d1\u65b0\u7597\u6cd5\" title=\"\u901f\u9012 | \u6b66\u7530\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u9488\u5bf9CD38\u5f00\u53d1\u65b0\u7597\u6cd5\"  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2Molecular Templates\u516c\u53f8\u836f\u7269\u7814\u53d1\u7ba1\u7ebf\uff08\u56fe\u7247\u6765\u6e90\uff1aMolecular Templates\u516c\u53f8\u5b98\u7f51\uff09<\/span><\/strong><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u672c\u6b21\u5408\u4f5c\u662f\u57fa\u4e8e\u6b66\u7530\u516c\u53f8\u5bf9\u4e8e\u5305\u62ec\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u5728\u5185\u7684\u591a\u79cd\u8840\u6db2\u764c\u75c7\u7684\u957f\u671f\u7ecf\u9a8c\uff0c\u201d\u6b66\u7530\u516c\u53f8\u80bf\u7624\u6cbb\u7597\u90e8\u4e3b\u7ba1Philip Rowlands\u535a\u58eb\u8bf4\uff1a\u201c\u901a\u8fc7\u4e0eMolecular Templates\u7684\u5408\u4f5c\u7814\u7a76\uff0c\u6211\u4eec\u770b\u5230\u4e86\u5176ETB\u5e73\u53f0\u5177\u6709\u7684\u53d1\u73b0\u53ca\u53d1\u5c55\u65b0\u7597\u6cd5\u7684\u6f5c\u529b\u3002\u901a\u8fc7\u8fd9\u6b21\u5408\u4f5c\u7684\u6269\u5c55\uff0c\u76f8\u4fe1\u6211\u4eec\u53ef\u4ee5\u4e3a\u60a3\u8005\u5e26\u6765\u66f4\u591a\u91cd\u8981\u7684\u521b\u65b0\u578b\u7597\u6cd5\u9009\u62e9\u3002\u201d<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u81ea2016\u5e74\u5341\u6708\u4ee5\u6765\uff0c\u6211\u4eec\u4e00\u76f4\u4e0e\u6b66\u7530\u516c\u53f8\u7684\u79d1\u5b66\u56e2\u961f\u7d27\u5bc6\u5408\u4f5c\uff0c\u7814\u53d1\u9776\u5411CD38\u7684ETBs\uff0c\u5e76\u6781\u5927\u6539\u8fdb\u4e86\u6211\u4eec\u7684\u5185\u90e8\u9879\u76eeMT-4019\uff0c\u201dMolecular Templates\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98\u517c\u79d1\u5b66\u5b98Eric Poma\u535a\u58eb\u8bf4\uff1a\u201c\u6709\u4e86\u6b66\u7530\u516c\u53f8\u5728\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u53ca\u6297\u4f53\u7814\u7a76\u65b9\u9762\u7684\u96c4\u539a\u4e13\u4e1a\u77e5\u8bc6\u53ca\u5b9e\u529b\u7684\u652f\u6301\uff0c\u6211\u4eec\u9009\u51fa\u4e86\u5728\u81ea\u5df1\u7684\u6280\u672f\u5e73\u53f0\u4e0a\u751f\u4ea7\u7684\u6240\u6709ETBs\u4e2d\u6700\u6709\u6f5c\u529b\u7684\u9776\u5411CD38\u7684ETB\uff0c\u5e76\u987a\u5229\u5bf9\u5176\u8fdb\u884c\u7814\u53d1\u3002\u6211\u4eec\u671f\u5f85\u5c06\u8fd9\u4e00\u9879\u76ee\u63a8\u8fdb\u81f3\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u3002\u201d<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6211\u4eec\u795d\u8d3aMolecular Templates\u4e0e\u6b66\u7530\u6b64\u6b21\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u5e76\u671f\u5f85\u65b0\u7684\u7597\u6cd5\u53ef\u4ee5\u65e9\u65e5\u5f00\u5c55\u4e34\u5e8a\u9636\u6bb5\u7684\u7814\u7a76\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] Molecular Templates Announces Agreement with Takeda for the Joint Development of a Protein-Based Oncology Therapy. Retrieved September 20, 2018, from http:\/\/ir.mtem.com\/news-releases\/news-release-details\/molecular-templates-announces-agreement-takeda-joint-development<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] Multiple&nbsp;<\/span><span class=\"\" style=\"font-size: 10px;color: rgb(178, 178, 178);\">myeloma<\/span><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">&nbsp;&#8211; Wikipedia. Retrieved September 20, 2018, from https:\/\/en.wikipedia.org\/wiki\/Multiple_myeloma<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"background-color: rgb(255, 255, 255);color: rgb(178, 178, 178);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 10px;letter-spacing: 0.544px;text-align: justify;\">\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><br  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;word-break: normal !important;\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;overflow-wrap: break-word !important;word-break: normal !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;word-break: normal !important;\"  \/><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;word-break: normal !important;\">\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u4f4d\u4e8e\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u5dde\u5967\u65af\u6c40\u5e02\u7684\u751f\u7269\u6280\u672f\u516c\u53f8Molecular Templates\u8fd1\u65e5\u5ba3\u5e03\u4e0e\u6b66\u7530 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":49009,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49008"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=49008"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49008\/revisions"}],"predecessor-version":[{"id":49012,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49008\/revisions\/49012"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/49009"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=49008"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=49008"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=49008"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}