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\n

\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/p>\n


<\/span><\/strong><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/p>\n

\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u7597\u6cd5\uff08ART\uff09\u9769\u547d\u6027\u5730\u6539\u53d8\u4e86\u5bf9\u827e\u6ecb\u75c5\uff08AIDS\uff09\u75c5\u539f\u4f53HIV\u7684\u6cbb\u7597\uff0c\u4f46\u4e00\u5ea6\u81f4\u547d\u7684\u827e\u6ecb\u75c5\u4ecd\u4e0d\u80fd\u88ab\u6cbb\u6108\u3002<\/span><\/strong>HIV\u4e0d\u80fd\u88ab\u5f7b\u5e95\u6e05\u9664\u7684\u4e3b\u8981\u969c\u788d\uff0c\u662f\u7531\u4e8eHIV\u7684\u6f5c\u4f0f\u611f\u67d3\u7ec6\u80de\u6240\u6784\u6210\u7684\u6f5c\u4f0f\u50a8\u5e93(reservoir)\u7684\u5b58\u5728\u3002\u5904\u4e8e\u6f5c\u4f0f\u72b6\u6001\u7684HIV\u591a\u4ee5cDNA\u7684\u5f62\u5f0f\u6574\u5408\u81f3\u5bbf\u4e3b\u57fa\u56e0\u7ec4\u4e2d\uff0c\u4e0d\u6613\u53d7\u5230\u9ad8\u6548ART\u836f\u7269\u7684\u4f5c\u7528\u3002\u5982\u4f55\u6fc0\u6d3b\u6f5c\u4f0f\u50a8\u5e93\uff0c\u5e76\u8054\u5408\u9ad8\u6548ART\u836f\u7269\u8fdb\u884c\u6740\u706d\uff0c\u662f\u6839\u6cbb\u827e\u6ecb\u75c5\u6781\u5177\u6311\u6218\u6027\u7684\u5173\u952e\u95ee\u9898\u3002<\/strong><\/span><\/p>\n


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\u901a\u8fc7\u4f7f\u7528\u5177\u6709\u836f\u7406\u6d3b\u6027\u7684HIV\u6f5c\u4f0f\u671f\u9006\u8f6c\u5242\uff0c\u53ef\u8bf1\u5bfc\u75c5\u6bd2\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u8ba9\u75c5\u6bd2\u88abT\u7ec6\u80de\u653b\u51fb\u3002\u4f46\u662f\uff0c\u63a5\u53d7ART\u6cbb\u7597\u7684\u60a3\u8005\u4f53\u5185\u9488\u5bf9HIV\u514d\u75ab\u53cd\u5e94\u4e0d\u8db3\uff0c\u5373\u4f7f\u5728\u6f5c\u4f0f\u671f\u9006\u8f6c\u5242\u7684\u5e2e\u52a9\u4e0b\uff0c\u4e5f\u96be\u4ee5\u6e05\u9664\u73b0\u6709\u75c5\u6bd2\u611f\u67d3\u3002<\/strong><\/span><\/p>\n

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\u5317\u5361\u5927\u5b66\u6559\u5802\u5c71\u5206\u6821\uff08UNC-Chapel Hill\uff09\u7684\u79d1\u5b66\u5bb6\u4eec\u5728\u8fd1\u671f\u7684\u300aMolecular Therapy\u300b\u4e0a\uff0c\u62a5\u9053\u4e86\u4ed6\u4eec\u7528\u514d\u75ab\u7597\u6cd5\uff0c\u5982\u4f55\u6e05\u9664\u4eba\u4f53\u5185\u5b58\u7559\u7684HIV\u75c5\u6bd2\u3002<\/span><\/strong>\u5728\u4e00\u98791\u671f\u4e34\u5e8a\u5b9e\u9a8c\u4e2d\uff0c\u4ed6\u4eec\u4f53\u5916\u6269\u589e\u6765\u81ea\u4e8e\u63a5\u53d7\u8fc7ART\u7684\u60a3\u8005\u7684T\u7ec6\u80de\uff0c\u7136\u540e\u53c8\u5c06\u5176\u8f93\u56de\u60a3\u8005\u4f53\u5185\uff0c\u8bd5\u9a8c\u8bc1\u660e\u4e86\u8fd9\u4e00T\u7ec6\u80de\u7597\u6cd5\u5728\u6b64\u7c7b\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002<\/span><\/p>\n


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\u56e0\u6b64\uff0c\u4f7f\u7528\u514d\u75ab\u7597\u6cd5\uff0c\u53ef\u4ee5\u5c06HXTC\u8f93\u56de\u60a3\u8005\u4f53\u5185\uff0c\u7136\u540e\u7ed3\u5408Zolinza\u8fd9\u7c7b\u836f\u7269\u4ee5\u4f7fHIV\u6f5c\u4f0f\u50a8\u5e93\u88ab\u514d\u75ab\u7ec6\u80de\u8bc6\u522b\uff0c\u4ece\u800c\u8ba9T\u7ec6\u80de\u627e\u5230\u5e76\u6740\u6b7b\u8fd9\u4e9b\u75c5\u6bd2\uff0c\u4f46\u9996\u5148\u8981\u8bc1\u660e\u8fd9\u4e2a\u7b56\u7565\u7684\u7b2c\u4e00\u6b65\u662f\u5b89\u5168\u7684\uff0c\u800c\u8fd9\u6b63\u662f\u8fd9\u7bc7\u6587\u7ae0\u6240\u62a5\u9053\u7684\u3002<\/strong><\/span><\/p>\n


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\u6587\u7ae0\u7684\u7b2c\u4e00\u4f5c\u8005\uff0cJulia Sung\u535a\u58eb\u8bf4\uff1a\u201c\u8fd9\u6b21\u8bd5\u9a8c\u7684\u5b89\u5168\u6570\u636e\u4ee4\u4eba\u611f\u5230\u9f13\u821e\u3002\u5b83\u4e3a\u4e0b\u4e00\u6b65\u8bd5\u9a8c\u94fa\u5e73\u4e86\u9053\u8def\uff0c\u4e0b\u4e00\u6b65\u5b9e\u9a8c\u5c06\u628a\u514d\u75ab\u7597\u6cd5\u4e0e\u6f5c\u4f0f\u671f\u9006\u8f6c\u5242\u7ed3\u5408\u8d77\u6765\uff0c\u5c06HIV\u75c5\u6bd2\u4ece\u6f5c\u4f0f\u72b6\u6001\u4e2d\u6fc0\u6d3b\uff0c\u4f7f\u5176\u53ef\u4ee5\u88ab\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\uff0c\u968f\u540e\u88ab\u514d\u75ab\u7597\u6cd5\u6e05\u9664\u3002\u201d<\/span><\/p>\n

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\"\u524d\u6cbf<\/p>\n

\u25b2\u5317\u5361\u5927\u5b66\u6559\u5802\u5c71\u5206\u6821\u6559\u6388David Margolis\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1a\u5317\u5361\u5927\u5b66\u6559\u5802\u5c71\u5206\u6821\u5b98\u7f51\uff09<\/span><\/strong>
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\u8bd5\u9a8c\u56e2\u961f\u7684\u8054\u5408\u8d1f\u8d23\u4eba\uff0c\u5317\u5361\u5927\u5b66\u6559\u5802\u5c71\u5206\u6821\u6559\u6388David Margolis\u535a\u58eb\u8bf4\uff1a\u201c\u8fd9\u9879\u7814\u7a76\u7684\u91cd\u70b9\u662f\u627e\u5230\u4e00\u79cd\u65b9\u6cd5\u6765\u91cd\u65b0\u6559\u80b2\u8eab\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u66f4\u597d\u5730\u5bf9\u6297HIV\u611f\u67d3\u3002<\/strong>\u6211\u4eec\u53d1\u73b0\u8fd9\u79cd\u65b9\u6cd5\u91cd\u65b0\u6559\u80b2\u514d\u75ab\u7ec6\u80de\u5e76\u91cd\u65b0\u8f93\u6ce8\u662f\u5b89\u5168\u7684\uff0c\u8fd9\u662f\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u76ee\u6807\u3002<\/strong>\u8be5\u8bd5\u9a8c\u7684\u6570\u636e\u5c06\u7ee7\u7eed\u5e2e\u52a9\u6211\u4eec\u8bbe\u8ba1\u6539\u826f\u7684\u6297HIV\u514d\u75ab\u7597\u6cd5\u3002\u201d<\/span><\/p>\n


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\u8bd5\u9a8c\u56e2\u961f\u7684\u8054\u5408\u8d1f\u8d23\u4eba\uff0c\u56fd\u5bb6\u513f\u7ae5\u536b\u751f\u7cfb\u7edf\u7684Catherine Bollard\u535a\u58eb\u8bf4\uff1a \u201c\u5728\u5c06\u8fd9\u79cd\u65b9\u6cd5\u4e0e\u65e8\u5728\u53d6\u6d88HIV\u85cf\u533f\uff0c\u4ee5\u4fbf\u6539\u5584\u514d\u75ab\u53cd\u5e94\u7684\u65b9\u6cd5\u76f8\u7ed3\u5408\u4e4b\u524d\uff0c\u6211\u4eec\u9700\u8981\u9996\u5148\u786e\u5b9a\u8fd9\u79cd\u514d\u75ab\u7597\u6cd5\u672c\u8eab\u5c31\u662f\u5b89\u5168\u7684\u3002\u6211\u4eec\u5728\u7528\u75c5\u6bd2\u7279\u5f02\u6027T\u7ec6\u80de\u6cbb\u7597\u6f5c\u4f0f\u75c5\u6bd2\u60a3\u8005\u65b9\u9762\u62e5\u6709\u957f\u671f\u7ecf\u9a8c\uff0c\u6b64\u7c7b\u75c5\u6bd2\u5305\u62ecEpstein-Barr\u75c5\u6bd2\u548c\u5de8\u7ec6\u80de\u75c5\u6bd2\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u4e0e\u5317\u5361\u5927\u5b66\u56e2\u961f\u5408\u4f5c\uff0c\u4ee5\u671f\u5229\u7528\u8fd9\u79cd\u75c5\u6bd2\u7684\u7279\u5f02\u6027T\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u827e\u6ecb\u75c5\u3002<\/span><\/p>\n


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\u5317\u5361\u5927\u5b66\u6b63\u5728\u62db\u52df\u60a3\u8005\u8fdb\u884c\u4e00\u9879\u5c06Zolinza\u4e0e\u4ed6\u4eec\u81ea\u5df1\u7684HIV\u7279\u5f02\u6027T\u7ec6\u80de\u7ed3\u5408\u8d77\u6765\u7684\u7814\u7a76\u3002\u53c2\u4e0e\u8005\u5c06\u63a5\u53d720\u5242\u5316\u7597\u548c5\u6b21T\u7ec6\u80de\u8f93\u6ce8\u3002\u7814\u7a76\u4eba\u5458\u5e0c\u671b\u57282021\u5e74\u5b8c\u6210\u8fd9\u9879\u7814\u7a76\u3002<\/span><\/p>\n


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[1]. T-cell therapy for eradicating HIV reservoirs proves safe in <\/span>small<\/span> study. Retrieved September 21, 2018, from https:\/\/www.fiercebiotech.com\/research\/t-cell-therapy-for-t-cell-therapy-for-eradicating-hiv-reservoirs-proves-safe-small-study<\/span><\/p>\n

[2]. Proof-of-concept HIV immunotherapy study passes Phase 1 safety trial. Retrieved September 21, 2018, from https:\/\/www.eurekalert.org\/pub_releases\/2018-09\/cp-phi091318.php<\/span><\/p>\n

[3]. Margolis, et al., (2018). HIV-Specific, Ex Vivo Expanded T Cell Therapy: Feasibility, Safety, and Efficacy in ART-Suppressed HIV-Infected Individuals. Molecular Therapy, https:\/\/doi.org\/10.1016\/j.ymthe.2018.08.015<\/span><\/p>\n


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