{"id":4902,"date":"2018-06-17T01:00:00","date_gmt":"2018-07-27T06:57:51","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e7%aa%84%e6%b2%bb%e7%96%97%e6%8c%87%e6%95%b0%e8%8d%af%e7%89%a9%e7%9a%84%e7%94%9f%e7%89%a9%e7%ad%89%e6%95%88%e6%80%a7%e8%af%84%e4%bb%b7%e8%bf%9b%e5%b1%95\/"},"modified":"2018-07-27T14:57:53","modified_gmt":"2018-07-27T06:57:53","slug":"%e7%aa%84%e6%b2%bb%e7%96%97%e6%8c%87%e6%95%b0%e8%8d%af%e7%89%a9%e7%9a%84%e7%94%9f%e7%89%a9%e7%ad%89%e6%95%88%e6%80%a7%e8%af%84%e4%bb%b7%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/4902\/","title":{"rendered":"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;text-align: center;\"><strong style=\"max-width: 100%;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u7f6e\u9876\u201c<\/span><\/span><strong style=\"font-size: 16px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 82, 255);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/span><\/span><\/span><\/strong><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u201d\uff0c\u83b7\u53d6\u6700\u65b0\u8d44\u8baf<\/span>\uff01<\/span><\/span><\/strong><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"font-size: 12px;\">\u6587\u7ae0\u8f6c\u81ea\u9a6d\u65f6\u4e34\u5e8a\u8bd5\u9a8c\u4fe1\u606f\uff0c\u8f6c\u8f7d\u65e8\u5728\u5b66\u4e60\u4ea4\u6d41\u3001\u4e0d\u4f5c\u4efb\u4f55\u5546\u4e1a\u7528\u9014\uff0c\u5982\u6d89\u4fb5\u6743\u70e6\u8bf7\u8054\u7cfb\u5e73\u53f0\u8fdb\u884c\u5220\u9664\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><br  \/><\/p>\n<section class=\"\"  style=\" max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51); ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; \">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;line-height: 2;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532674672.jpeg\" alt=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\" title=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\"><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0px;word-wrap: break-word !important;\">[\u6458\u8981] &nbsp;<\/span><\/strong><span style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0px;word-wrap: break-word !important;\">\u8fd1\u5e74\u6765\u7a84\u6cbb\u7597\u6307\u6570\u7c7b\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u5907\u53d7\u5173\u6ce8\uff0c\u5173\u4e8e\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u751f\u7269\u7b49\u6548\u6027\u5982\u4f55\u8bc4\u4ef7\uff0c\u4e00\u4e9b\u8981\u70b9\u95ee\u9898\u5c1a\u5b58\u5f88\u5927\u7684\u4e89\u8bae\u3002\u76ee\u524d\u56e0\u5185\u5c1a\u65e0\u76f8\u5173\u6307\u5bfc\u539f\u5219\uff0c\u672c\u6587\u5206\u6790\u548c\u4ecb\u7ecd\u4e86\u7a84\u6cbb\u7597\u6307\u6570\u7c7b\u836f\u7269\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u7684\u56f0\u96be\u53ca\u4e3b\u8981\u89e3\u51b3\u65b9\u6cd5\uff0c\u53c2\u8003\u56fd\u5185\u5916\u6cd5\u89c4\u3001\u6307\u5bfc\u539f\u5219\u53ca\u76f8\u5173\u6587\u732e\uff0c\u5bf9\u7a84\u6cbb\u7597\u7a97\u836f\u7269\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u53ca\u53c2\u6bd4\u5236\u5242\u6821\u6b63\u7684\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027(RSABE)\u65b9\u6cd5\u5c55\u5f00\u4ecb\u7ecd\uff0c\u4ee5\u671f\u5bf9\u6211\u56fd\u7a84\u6cbb\u7597\u6307\u6570\u7c7b\u836f\u7269\u7684\u4eff\u5236\u836f\u8d28\u91cf\u4e0e\u7597\u6548\u4e00\u81f4\u6027\u8bc4\u4ef7\u5de5\u4f5c\u63d0\u4f9b\u501f\u9274\u548c\u5e2e\u52a9\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0px;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">[\u5173\u952e\u8bcd] &nbsp;<\/strong>\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\uff1b\u751f\u7269\u7b49\u6548\u6027\uff1b\u53c2\u6bd4\u5236\u5242\u6821\u6b63\u7684\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027(RSABE)<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u7a84\u6cbb\u7597\u6307\u6570(narrow therapeutic index,NTI)\u836f\u7269\u662f\u6307\u7ed9\u836f\u5242\u91cf\u6216\u8840\u836f\u6d53\u5ea6\u7684\u5fae\u5c0f\u53d8\u5316\u53ef\u80fd\u5f15\u8d77\u6cbb\u7597\u5931\u8d25\u6216\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff0c\u5371\u53ca\u751f\u547d\u3001\u5bfc\u81f4\u6301\u7eed\u6216\u660e\u663e\u7684\u6b8b\u75be\u53ca\u529f\u80fd\u4e0d\u5168\u7684\u836f\u7269\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">NTI\u836f\u7269\u5177\u6709\u4ee5\u4e0b\u7279\u6027:<\/strong><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">(1)\u6709\u6548\u836f\u7269\u5242\u91cf\u4e0e\u4e25\u91cd\u7fa4\u6027\u5242\u91cf\u5728\u4e00\u4e2a\u7a84\u7684\u8303\u56f4\u5185\uff0c\u5373\u534a\u6570\u81f4\u6b7b\u5242\u91cf(median lethal dose,LD50)\u548c\u534a\u6570\u6709\u6548\u5242\u91cf(median effective dose,ED50)\u4e4b\u95f4\u7684\u5dee\u5f02\u5c0f\u4e8e\u4e24\u500d\uff0c\u6216\u8005\u8840\u6db2\u4e2d\u6700\u4f4e\u6bd2\u6027\u6d53\u5ea6(minimum toxic concentrations,MTC)\u548c\u6700\u4f4e\u6709\u6548\u6d53\u5ea6(minimum effective concentrations,MEC)\u4e4b\u95f4\u7684\u5dee\u5f02\u5c0f\u4e8e\u4e24\u500d\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">(2)\u504f\u79bb\u6700\u4f73\u5242\u91cf\u6216\u6d53\u5ea6\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u7684\u6cbb\u7597\u5931\u8d25\uff0c\u9700\u57fa\u4e8e\u836f\u52a8\u5b66(PK)\u6216\u836f\u6548\u5b66(PD)\u6307\u6807\u4ed4\u7ec6\u8c03\u6574\u5242\u91cf\u548c\u6cbb\u7597\u836f\u7269\u76d1\u6d4b(therapeutic drug monitoring,TDM),\u4ee5\u786e\u4fdd\u836f\u7269\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">(3)\u4e2a\u4f53\u5185\u53d8\u5f02\u6027(within-subject variahility\uff0cWSV)\u8f83\u5c0f\uff08\u4e0d\u8d85\u8fc730%),\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u5bf9\u5242\u91cf\u7684\u8c03\u6574\u65f6\uff0c\u901a\u5e38\u4ee5\u975e\u5e38\u5c0f\u7684\u589e\u91cf\uff08\u5c0f\u4e8e20%)\u8fdb\u884c\u8c03\u6574\u3002Tab.1\u663e\u793a\u90e8\u5206NTI\u836f\u7269\u7684\u7279\u6027\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532674672.png\" alt=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\" title=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\"><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u56fd\u5185\u5916\u76d1\u7ba1\u673a\u6784\u4f7f\u7528\u4e0d\u540c\u7684\u672f\u8bed\u8868\u793aNTI\u836f\u7269\uff0c\u5982\u201c\u4e34\u754c\u5242\u91cf\u836f\u7269\u201d(critical dose drugs)\u3001\uff02\u7a84\u6cbb\u7597\u7a97\u836f\u7269&#8221;(narrow treatment window drugs)\u548c\u201c\u7a84\u6cbb\u7597\u8303\u56f4\u836f\u7269&#8221;(narrow therapeutic range drugs)\u7b49\u3002FDA\u7f51\u7ad9\u516c\u5e03\u7684\u300a\u7279\u5b9a\u836f\u7269\u751f\u7269\u7b49\u6548\u6027\u6307\u5bfc\u539f\u5219\u300b\u4e2d\u5c5e\u4e8eNTI\u836f\u7269\u6709\u534e\u6cd5\u6797\u94a0\u7247\u3001\u5361\u9a6c\u897f\u5e73\u7247\u3001\u82ef\u59a5\u82f1\u94a0\u7f13\u91ca\u80f6\u56ca\u3001\u4ed6\u514b\u83ab\u53f8\u80f6\u56ca\u3001\u5de6\u7532\u72b6\u817a\u7d20\u94a0\u7b49\u3002\u300a\u7279\u5b9a\u836f\u7269\u751f\u7269\u7b49\u6548\u6027\u6307\u5bfc\u539f\u5219\u300b\u5217\u51faNTI\u836f\u7269\u7684\u7279\u70b9\uff0c\u5e76\u4ee5\u300a\u534e\u6cd5\u6797\u94a0\u751f\u7269\u7b49\u6548\u6027\u6307\u5bfc\u539f\u5219\u300b\uff08\u8349\u6848\uff09\u4e3a\u4f8b\u4f5c\u4e86\u8be6\u7ec6\u8bf4\u660e\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u751f\u7269\u7b49\u6548\u6027(bioequivalence,BE)\u662f\u5728\u76f8\u4f3c\u7684\u8bd5\u9a8c\u6761\u4ef6\u4e0b\uff0c\u5355\u6b21\u6216\u591a\u6b21\u670d\u7528\u76f8\u540c\u5242\u626f\u7684\u8bd5\u9a8c\u836f\u7269\u540e\uff0c\u53d7\u8bd5\u5236\u5242\u4e2d\u836f\u7269\u7684\u5438\u6536\u901f\u5ea6\u548c\u5438\u6536\u7a0b\u5ea6\u4e0e\u53c2\u6bd4\u5236\u5242\u7684\u5dee\u5f02\u5728\u53ef\u63a5\u53d7\u8303\u56f4\u5185\u3002FDA\u5c06\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u6307\u6807\u8fdb\u884c\u5206\u7c7b:\u836f\u4ee3\u52a8\u529b\u5b66\u7ec8\u70b9\u6307\u6807(phannacokinetic endpoint)\u3001\u836f\u6548\u52a8\u529b\u5b66\u7ec8\u70b9\u6307\u6807(phannacodynamic endpoint)\u3001\u4e34\u5e8a\u7ec8\u70b9\u6307\u6807(clinical endpoint)\u3001\u4f53\u5916\u7ec8\u70b9\u6307\u6807(in vitro endpoint),\u4ee5\u836f\u4ee3\u52a8\u529b\u5b66\u7ec8\u70b9\u6307\u6807\u6700\u4e3a\u5e38\u7528\u3002\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u5178\u300b\u6307\u51fa\u5728\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u4e2d\u9700\u8981\u5206\u6790\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u53c2\u6570\u662f\u8840\u836f\u6d53\u5ea6\u65f6\u95f4\u66f2\u7ebf\u4e0b\u9762\u79ef(AUC(O-t))\u548c\u5cf0\u6d53\u5ea6(Cmax)\u3002\u53d7\u8bd5\u5236\u5242(T)\u548c\u53c2\u6bd4\u5236\u5242(R)\u7684AUC\u548cCmax\u7ecf\u5bf9\u6570\u8f6c\u6362\uff0c\u5176\u51e0\u4f55\u5747\u503c\u6bd4(geometric mean ratio,GMR)\u8fdb\u884c\u53cc\u5411\u5355\u4fa7t\u68c0\u9a8c\u5e76\u8ba1\u7b9790%\u7f6e\u4fe1\u533a\u95f4(confidence interval,CI),\u5e94\u8be5\u843d\u5728\u53ef\u63a5\u53d7\u8303\u56f480.00%-125.00%\u4e4b\u5185\uff0c\u4e0b\u9650\u820d\u5165\u540e\u4fdd\u7559\u4e24\u4f4d\u5c0f\u6570\u5e94&gt;80.00%,\u4e0a\u9650\u820d\u5165\u540e\u4fdd\u7559\u4e24\u4f4d\u5c0f\u6570\u5e94&lt;125.00%\u3002\u8fd9\u4e00\u6807\u51c6\u9002\u7528\u4e8e\u5927\u591a\u6570\u836f\u7269\uff0c\u4f46\u662f\u5bf9\u4e8eWSV\u5c0f\u7684NTI\u7c7b\u836f\u7269\uff0c\u5e94\u91c7\u7528\u4e0d\u540c\u7684\u8bc4\u4ef7\u65b9\u6cd5,\u5982Fig.1\u6240\u793a\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532674672.jpeg\" alt=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\" title=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\"><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u56fd\u5185\u5916\u5bf9NTI\u836f\u7269BE\u7814\u7a76\u7684\u6cd5\u89c4\u8981\u6c42\u57fa\u672c\u4e0a\u5206\u4e3a\u4e24\u79cd\u65b9\u6cd5\uff1a\u76f4\u63a5\u7f29\u7a84\u5e73\u5747\u751f\u7269\u7b49\u6548\u9650\u65b9\u6cd5(direct tightening of average bioequivalence limits)\u548c\u57fa\u4e8e\u53c2\u6bd4\u5236\u5242\u6821\u6b63\u7684\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u65b9\u6cd5(reference-scaled average bioequivalence,RSABE)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\" max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51); ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; \">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\" max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51); ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; \">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: bottom;width: 0px;border-width: 5px;border-style: solid;border-color: rgb(179, 178, 179) rgb(179, 178, 179) transparent transparent;word-wrap: break-word !important;\"><\/section>\n<section class=\"\" style=\"padding: 5px 8px;max-width: 100%;box-sizing: border-box;border-radius: 4px 4px 0px 0px;display: inline-block;vertical-align: top;background-color: rgb(249, 110, 87);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\u76f4\u63a5\u7f29\u7a84\u5e73\u5747\u751f\u7269\u7b49\u6548\u9650\u65b9\u6cd5<\/strong><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: bottom;width: 0px;border-width: 5px;border-style: solid;border-color: rgb(179, 178, 179) transparent transparent rgb(179, 178, 179);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\" max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51); ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; \">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;line-height: 2;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u8003\u8651\u4e3b\u8981\u836f\u4ee3\u52a8\u529b\u5b66\u53c2\u6570GMR\u768490%CI\u572880.00%-125.00%\u53ef\u80fd\u8fc7\u4e8e\u5bbd\u677e\uff0c\u4e00\u4e9b\u76d1\u7ba1\u673a\u6784\u91c7\u53d6\u76f4\u63a5\u7f29\u7a84\u751f\u7269\u7b49\u6548\u6027\u9650\u5ea6\u5230\u4e00\u4e2a\u66f4\u5c0f\u7684\u8303\u56f4\u3002\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u5178\u300b2015\u5e74\u7248\u7b2c4\u90e8\u300a\u836f\u7269\u5236\u5242\u751f\u7269\u5229\u7528\u5ea6\u548c\u751f\u7269\u7b49\u6548\u6027\u6307\u5bfc\u539f\u5219\u300b\u6307\u51fa:\u5728\u836f\u54c1\u6cbb\u7597\u8303\u56f4\u7a84\u7684\u7279\u6b8a\u60c5\u51b5\u4e0b\u63a5\u53d7\u8303\u56f4\u53ef\u80fd\u9700\u800d\u7f29\u5c0f\u3002AUC\u7684\u53ef\u63a5\u53d7\u533a\u95f4\u5e94\u8be5\u88ab\u7f29\u7a84\u4e3a90.00%-111.11%\u3002\u5728Cmax\u5bf9\u5b89\u5168\u6027\u3001\u836f\u6548\u6216\u836f\u7269\u6d53\u5ea6\u76d1\u6d4b\u7279\u522b\u91cd\u8981\u7684\u60c5\u51b5\uff0c\u8be5\u53c2\u6570\u4e5f\u5e94\u9002\u752890.00%-111.11%\u7684\u63a5\u53d7\u9650\u3002\u5e94\u8be5\u6839\u636e\u4e34\u5e8a\u8003\u8651\uff0c\u89c6\u5177\u4f53\u60c5\u51b5\u51b3\u5b9a\u4e00\u79cd\u6d3b\u6027\u7269\u8d28\u662f\u5426\u4e3a\u6cbb\u7597\u6307\u7a84\u7684\u836f\u7269\u30022016\u5e74CFDA\u503e\u5e03\u7684\u5173\u4e8e\u53d1\u5e03\u6614\u901a\u53e3\u670d\u540c\u4f53\u5236\u5242\u53c2\u6bd4\u5236\u5242\u9009\u62e9\u548c\u786e\u5b9a\u7b493\u4e2a\u6280\u672f\u6307\u5bfc\u539f\u5219\u7684\u901a\u544a\uff082016\u5e74\u7b2c61\u53f7\uff09\u4e2d\u300a\u4ee5\u836f\u52a8\u5b66\u53c2\u6570\u4e3a\u7ec8\u70b9\u8bc4\u4ef7\u6307\u6807\u7684\u5316\u5b66\u836f\u7269\u4eff\u5236\u836f\u4eba\u4f53\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\u6307\u51fa\uff1a\u5bf9\u4e8e\u7a84\u6cbb\u7597\u7a97\u836f\u7269\uff0c\u5e94\u6839\u636e\u836f\u7269\u7684\u7279\u6027\u9002\u5f53\u7f29\u5c0f90%\u7f6e\u4fe1\u533a\u95f4\u8303\u56f4\u3002\u7f8e\u56fd\u3001\u6b27\u76df\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9a\u7b49\u5730\u5bf9NTI\u836f\u7269\u4f7f\u7528\u4e86\u66f4\u4e25\u683c\u7684BE\u7b49\u6548\u9650\u63a5\u53d7\u9650\u5ea6\u3002\u52a0\u62ff\u5927\u548c\u65e5\u672c\u5206\u522b\u5c06NTI\u836f\u7269\u79f0\u4e3a\u4e34\u754c\u5242\u91cf\u836f\u7269\u548c\u7a84\u6cbb\u7597\u8303\u56f4\u836f\u7269\uff0c\u5e76\u90fd\u5728\u5176\u5404\u81ea\u7684\u6307\u5357\u4e2d\u63d0\u4f9b\u4e86\u5b9a\u4e49(Tab.2)\u3002\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40(EMA)\u7684\u7ed3\u8bba\u662f\uff0c\u65e0\u6cd5\u786e\u5b9a\u4e00\u5957\u5c06\u836f\u7269\u5206\u7c7b\u4e3aNTI\u7684\u6807\u51c6\uff0c\u5e76\u5efa\u8bae\u5728\u4e2a\u6848\u57fa\u7840\u4e0a\u4f5c\u51fa\u51b3\u5b9a\u3002\u5177\u4f53\u6cd5\u89c4\u8981\u6c42\u53ca\u5176\u6240\u5217\u51faNTI\u836f\u7269\u5982Tab.2\u6240\u793a\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532674672.jpeg\" alt=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\" title=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\"><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\" max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51); ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; \">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;width: 0px;border-width: 5px;border-style: solid;border-color: transparent rgb(179, 178, 179) rgb(179, 178, 179) transparent;word-wrap: break-word !important;\"><\/section>\n<section class=\"\" style=\"padding: 5px 8px;max-width: 100%;box-sizing: border-box;border-radius: 0px 0px 4px 4px;display: inline-block;vertical-align: top;background-color: rgb(249, 110, 87);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">RSABE\u65b9\u6cd5<\/strong><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;width: 0px;border-width: 5px;border-style: solid;border-color: transparent transparent rgb(179, 178, 179) rgb(179, 178, 179);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\" max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51); ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; \">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;line-height: 2;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">2010\u5e74FDA\u5728\u836f\u7269\u79d1\u5b66\u548c\u4e34\u5e8a\u836f\u7406\u5b66\u54a8\u8be2\u59d4\u5458\u4f1a(Advisory Committee for Pharmaceutical Science and Clinical Pharmacology,ACPSCP)\u4e0a\u6307\u51faAUC\u3001Cmax\u7b49\u836f\u52a8\u5b66\u53c2\u657090%CI\u7684\u7b49\u6548\u9650\u8303\u56f4\u572880.00%-125.00%\u4e4b\u5185\u4e0d\u8db3\u4ee5\u8bf4\u660eNTI\u836f\u7269\u7684BE\u7b49\u6548\u6027,FDA\u968f\u4e4b\u5f00\u5c55\u4e86\u4e0d\u540cBE\u7814\u7a76\u65b9\u6cd5\u4ee5\u6a21\u62df\u5728NTI\u836f\u7269\u7814\u7a76\u4e2d\u7684\u5e94\u7528\uff0c\u4e3b\u8981\u5305\u62ec\u76f4\u63a5\u7f29\u7a84\u5e73\u5747\u751f\u7269\u7b49\u6548\u6027\u9650\u65b9\u6cd5\u548cRSABE\u65b9\u6cd5\u30022011\u5e74\u5728ACPSCP\u4f1a\u8bae\u4e0a\u63d0\u4ea4\u7684\u6a21\u62df\u7ed3\u679c\u8868\u660eRSABE\u65b9\u6cd5\u662f\u8bc4\u4f30NTI\u836f\u7269BE\u7684\u9996\u9009\u65b9\u6cd5,\u57fa\u4e8e\u4ee5\u4e0a\u52aa\u529b\uff0cFDA\u57282012\u5e7412\u6708\u53d1\u5e03\u4e86\u300a\u534e\u6cd5\u6797\u94a0\u751f\u7269\u7b49\u6548\u6027\u6307\u5357\u300b\u8349\u6848\uff0c\u4ee5\u6b64\u4e3a\u53c2\u9605\u6807\u51c6\u5bf9NTI\u836f\u7269\u7684BE\u4f5c\u4e86\u8f83\u4e3a\u8be6\u7ec6\u7684\u8bf4\u660e\uff0c\u5efa\u8bae\u5bf9NTI\u836f\u7269\u8fdb\u884c\u56db\u5468\u671f\u3001\u53cc\u5e8f\u5217\u3001\u5b8c\u5168\u91cd\u590d\u7684\u4ea4\u53c9\u8bbe\u8ba1(a four-way\uff0ctwo-sequence\uff0cfully replicated crossver design),\u4ee5\u8bc4\u4f30T\u548cR\u7684WSV,\u5e76\u4f7f\u7528RSABE\u65b9\u6cd5\u5bf9\u76f8\u5173\u836f\u52a8\u5b66\u53c2\u6570\u8fdb\u884c\u7edf\u8ba1\u6bd4\u8f83\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532674673.jpeg\" alt=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\" title=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532674673.jpeg\" alt=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\" title=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\"><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress9-1532674673.png\" alt=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\" title=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\"><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">Tab.3\u4e3a\u67d0NTI\u836f\u7269(X)T\u548cR\u4e3b\u8981\u836f\u4ee3\u52a8\u529b\u5b66\u53c2\u6570\uff08\u53d7\u8bd5\u5236\u5242\u4e3aT,\u53c2\u6bd4\u5236\u5242\u4e3aR)\u3002\u91c7\u7528RSABE\u65b9\u6cd5\u5bf912\u540d\u53d7\u8bd5\u8005\u56db\u5468\u671f\u3001\u53cc\u5e8f\u5217\u3001\u5b8c\u5168\u91cd\u590d\u7684\u4ea4\u53c9\u8bbe\u8ba1(TRTR\u3001RTRT)\u7684AUC\u548cCmax\u8fdb\u884c\u5b9a\u91cf\u8ba1\u7b97\uff0c\u7ed3\u679c\u89c1Tab.3\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532674673-1.jpeg\" alt=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\" title=\"\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fdb\u5c55\"><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u7531\u516c\u5f0f5\u8ba1\u7b97\u5f97AUC\u4e2a\u4f53\u5185\u6807\u51c6\u5deeSWR\u4e3a0.1462,\u7531\u516c\u5f0f4\u53ef\u5f97AUC\u7684WSV\u4e3a14.70%,\u7ecf\u8ba1\u7b97AUC\u7684T\u548cR\u51e0\u4f55\u5747\u503c\u6bd490%CI\u843d\u5728\u7531RSABE\u65b9\u6cd5\u5f97\u51fa\u7684\u53ef\u63a5\u53d7\u9650\u8303\u56f4\u5185(86.99%~116.66%)\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">\u53e6\u5916\uff0cCmax\u7684SWR\u4e3a0.1737,WSV\u4e3a17.50%,\u7ecf\u8ba1\u7b97Cmax\u7684T\u548cR\u51e0\u4f55\u5747\u503c\u6bd490%CI\u672a\u843d\u5728\u7531RSABE\u65b9\u6cd5\u5f97\u51fa\u7684\u53ef\u63a5\u53d7\u9650\u8303\u56f4\u5185(84.75%-120.08%)\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">NTI\u836f\u7269\u6cbb\u7597\u7a97\u7a84\u4e14\u6bd2\u6027\u5927\uff0c\u5242\u91cf\u5fae\u5c0f\u53d8\u5316\u53ef\u80fd\u4f1a\u5bfc\u81f4\u4e25\u91cd\u7684\u6cbb\u7597\u5931\u8d25\u6216\u4e0d\u826f\u53cd\u5e94\uff0c\u56e0\u6b64\u7528\u4eff\u5236\u836f\u66ff\u6362\u539f\u7814\u836f\uff0c\u5b58\u5728\u4e00\u5b9a\u7684\u98ce\u9669\u3002\u672c\u6587\u4ecb\u7ecd\u4e86NTI\u836f\u7269\u8bc4\u4ef7\u65b9\u6cd5\u53ca\u8fdb\u5c55\uff0c\u91cd\u70b9\u8ba8\u8bba\u4e86\u56fd\u5185\u5916\u5148\u8fdb\u76d1\u7ba1\u673a\u6784\u5bf9NTI\u836f\u7269\u7684\u6cd5\u89c4\u8981\u6c42\u53ca\u65b9\u6cd5\uff0c\u7279\u522b\u662f\u76f4\u63a5\u7f29\u7a84\u5e73\u5747\u751f\u7269\u7b49\u6548\u9650\u65b9\u6cd5\u548cRSABE\u65b9\u6cd5\u3002FDA\u5efa\u8baeRSABE\u65b9\u6cd5\u4f5c\u4e3aNTI\u836f\u7269\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u7684\u9996\u9009\u65b9\u6cd5\uff0c\u5373\u5229\u7528\u53c2\u6bd4\u5236\u5242\u7684\u4e2a\u4f53\u5185\u53d8\u5f02\u5bf9\u751f\u7269\u7b49\u6548\u9650\u4f5c\u6bd4\u4f8b\u5316\u8c03\u6574\uff0cRSABE\u65b9\u6cd5\u5df2\u88ab\u6210\u529f\u8fd0\u7528\u4e8e\u9ad8\u53d8\u5f02\u836f\u7269(highly variable drug)\u7684BE\u8bc4\u4ef7\u3002\u5bf9NTI\u836f\u7269\u5e94\u7528RSABE\u65b9\u6cd5\u4f7f\u5f97\u53ef\u63a5\u53d7\u9650\u76f8\u5e94\u7f29\u7a84\u3002\u8fd9\u79cd\u7edf\u8ba1\u65b9\u6cd5\u5c06\u589e\u52a0\u4f18\u8d28NTI\u4eff\u5236\u836f\u7269\u83b7\u6279\u7684\u540c\u65f6\u907f\u514d\u8ba9\u6cbb\u7597\u4e0d\u7b49\u6548\u7684\u4ea7\u54c1\u8fdb\u5165\u5e02\u573a\u56e2\u3002NTI\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bd5\u9a8c\u662f\u4e00\u4e2a\u6bd4\u8f83\u590d\u6742\u7684\u95ee\u9898\uff0c\u8d8a\u6765\u8d8a\u53d7\u5230\u4e1a\u5185\u7684\u5173\u6ce8\u3002\u5bf9\u4e8eNTI\u836f\u7269\u3001\u9ad8\u53d8\u5f02\u836f\u7269\u7b49\u7279\u6b8a\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\uff0c\u5728\u8bd5\u9a8c\u8bbe\u8ba1\u3001\u6837\u672c\u91cf\u8ba1\u7b97\u3001\u68c0\u6d4b\u5bf9\u8c61\u3001\u5b9a\u91cf\u8bc4\u4ef7\u6307\u6807\u7b49\u9009\u62e9\u4e0a\u5404\u81ea\u5b58\u5728\u7279\u6b8a\u6027\uff0c\u56fd\u5916\u76d1\u7ba1\u5df2\u6709\u76f8\u5173\u7684\u6307\u5bfc\u539f\u5219\u53ef\u4ee5\u501f\u9274\u3002\u76ee\u524d\u6211\u56fd\u5c1a\u65e0\u9488\u5bf9NTI\u836f\u7269\u7684\u76f8\u5173\u6307\u5bfc\u539f\u5219\uff0c\u4e5f\u672a\u89c1\u5b98\u7f51\u516c\u5e03NTI\u836f\u7269\u540d\u5355\u3002\u9488\u5bf9\u7a84\u6cbb\u7597\u6307\u6570\u836f\u7269\u7684\u751f\u7269\u7b49\u6548\u6027\u8bc4\u4ef7\u8fd8\u9700\u66f4\u52a0\u6df1\u5165\u7ec6\u81f4\u7684\u7814\u7a76\u548c\u63a2\u8ba8\uff0c\u5e76\u5c3d\u65e9\u5236\u5b9a\u51fa\u76f8\u5e94\u7684\u6307\u5357\u548c\u6807\u51c6\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;font-size: 14px;color: rgb(142, 201, 101);word-wrap: break-word !important;\">\u53c2\u8003\u6587\u732e\uff08\u7565\uff09<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;font-size: 14px;color: rgb(12, 162, 234);word-wrap: break-word !important;\">\u4f5c\u8005\u53ca\u5355\u4f4d\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;font-size: 14px;color: rgb(12, 162, 234);word-wrap: break-word !important;\">\u5f90\u6bdb\u8fea\u3001\u5434\u5b50\u9759\u3001\u8c22\u6d77\u68e0<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;font-size: 14px;color: rgb(12, 162, 234);word-wrap: break-word !important;\">\u7696\u5357\u533b\u5b66\u9662 \u7696\u5357\u533b\u5b66\u9662\u9644\u5c5e\u5f0b\u77f6\u5c71\u533b\u9662\u4e34\u5e8a\u836f\u5b66\u90e8<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;font-size: 14px;color: rgb(12, 162, 234);word-wrap: break-word !important;\">\u6765\u6e90\uff1a\u4e2d\u56fd\u4e34\u5e8a\u836f\u7406\u5b66\u4e0e\u6cbb\u7597\u5b66 2017\u5e7411\u671f<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\">\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                                               <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f6e\u9876\u201c\u201d\uff0c\u83b7\u53d6\u6700\u65b0\u8d44\u8baf\uff01 \u6587\u7ae0\u8f6c\u81ea\u9a6d\u65f6\u4e34\u5e8a\u8bd5\u9a8c\u4fe1\u606f\uff0c\u8f6c\u8f7d\u65e8\u5728\u5b66\u4e60\u4ea4\u6d41\u3001\u4e0d\u4f5c\u4efb\u4f55\u5546\u4e1a\u7528\u9014\uff0c\u5982\u6d89\u4fb5\u6743\u70e6\u8bf7\u8054\u7cfb\u5e73\u53f0\u8fdb [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4903,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4902"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=4902"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4902\/revisions"}],"predecessor-version":[{"id":4912,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/4902\/revisions\/4912"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/4903"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=4902"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=4902"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=4902"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}