{"id":49082,"date":"2018-09-21T01:00:00","date_gmt":"2018-09-26T01:54:58","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e5%89%8d%e6%b2%bf-science%ef%bc%9a%e9%99%8d%e4%bd%8e%e9%98%bf%e7%89%87%e8%8d%af%e7%89%a9%e4%b8%8a%e7%98%be%e9%a3%8e%e9%99%a9%e7%9a%84%e6%96%b0%e5%9e%8b%e6%ad%a2%e7%97%9b%e8%8d%af%e6%9c%89%e5%93%aa\/"},"modified":"2018-09-26T09:55:00","modified_gmt":"2018-09-26T01:55:00","slug":"%e5%89%8d%e6%b2%bf-science%ef%bc%9a%e9%99%8d%e4%bd%8e%e9%98%bf%e7%89%87%e8%8d%af%e7%89%a9%e4%b8%8a%e7%98%be%e9%a3%8e%e9%99%a9%e7%9a%84%e6%96%b0%e5%9e%8b%e6%ad%a2%e7%97%9b%e8%8d%af%e6%9c%89%e5%93%aa","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/49082\/","title":{"rendered":"\u524d\u6cbf | Science\uff1a\u964d\u4f4e\u963f\u7247\u836f\u7269\u4e0a\u763e\u98ce\u9669\u7684\u65b0\u578b\u6b62\u75db\u836f\u6709\u54ea\u4e9b\uff1f"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<h1 style=\"margin-bottom: 0.8em;font-weight: inherit;font-size: 1.7em;white-space: normal;max-width: 100%;box-sizing: border-box;word-wrap: break-word;color: rgb(51, 51, 51);\" ><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word 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1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537926899.jpg\" alt=\"\u524d\u6cbf | Science\uff1a\u964d\u4f4e\u963f\u7247\u836f\u7269\u4e0a\u763e\u98ce\u9669\u7684\u65b0\u578b\u6b62\u75db\u836f\u6709\u54ea\u4e9b\uff1f\" title=\"\u524d\u6cbf | Science\uff1a\u964d\u4f4e\u963f\u7247\u836f\u7269\u4e0a\u763e\u98ce\u9669\u7684\u65b0\u578b\u6b62\u75db\u836f\u6709\u54ea\u4e9b\uff1f\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u963f\u7247\u7c7b\u836f\u7269\u662f\u5f3a\u529b\u6b62\u75db\u836f\u7684\u539f\u56e0\u662f\u4ed6\u4eec\u53ef\u4ee5\u4e0e\u5927\u8111\u548c\u810a\u9ad3\u4e2d\u4e00\u4e2a\u5173\u952e\u6027\u819c\u86cb\u767d\u76f8\u7ed3\u5408\uff0c\u8fd9\u5c31\u662f\u00b5\u963f\u7247\u53d7\u4f53\uff08MOR\uff09\u3002\u5f53MOR\u88ab\u6fc0\u6d3b\u4ee5\u540e\uff0c\u5b83\u80fd\u591f\u901a\u8fc7\u7ec6\u80de\u5185G\u86cb\u767d\u6765\u5f15\u53d1\u5206\u5b50\u7ea7\u8054\u53cd\u5e94\uff0c\u5bfc\u81f4\u75bc\u75db\u7f13\u89e3\u3002\u4f46\u662f\u4f20\u7edf\u7684\u963f\u7247\u7c7b\u836f\u7269\u540c\u65f6\u4f1a\u6fc0\u6d3b\u53e6\u4e00\u4e2a\u7ec6\u80de\u5185\u86cb\u767d\uff0c\u5b83\u5c31\u662f\u03b2\u6291\u5236\u86cb\u767d\uff08\u03b2-arrestin\uff09\u3002\u8fd9\u79cd\u86cb\u767d\u4f1a\u5bfc\u81f4\u547c\u5438\u6291\u5236\u548c\u4fbf\u79d8\uff0c\u5b83\u4eec\u662f\u963f\u7247\u7c7b\u836f\u7269\u6700\u5e38\u89c1\u7684\u526f\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u65e5\u524d\u5728\u65e7\u91d1\u5c71\u4e3e\u884c\u7684\u7f8e\u56fd\u5316\u5b66\u4f1a\uff08ACS\uff09\u7684\u4f1a\u8bae\u4e0a\uff0c\u4f4d\u4e8e\u65e7\u91d1\u5c71\u7684Nektar Therapeutics\u516c\u53f8\u63d0\u51fa\u4e86\u4e00\u4e2a\u65b0\u7b56\u7565\u3002\u8be5\u516c\u53f8\u7684<\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDA5NTIxNQ==&amp;mid=2649975436&amp;idx=5&amp;sn=f611d618aa86162008a8c7eab7f1c718&amp;chksm=82e9ec0cb59e651aa584fed1e3e3ebfa18b7ebb58e3c6fb4211425178463f03b6bd1b5a7d383&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;font-size: 15px;color: rgb(0, 112, 192);\"><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">NKTR-181<\/span><\/a><span style=\"font-size: 15px;\">\u662f\u4e00\u79cd\u6539\u826f\u7684\u7f9f\u8003\u916e\uff08oxycodone\uff09\u3002\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0c<strong>\u5b83\u8de8\u8d8a\u8840\u8111\u5c4f\u969c\u7684\u901f\u5ea6\u6bd4\u7f9f\u8003\u916e\u8981\u616270\u500d<\/strong>\u3002\u901a\u5e38\u7f9f\u8003\u916e\u4f1a\u89e6\u53d1\u4e00\u4e2a\u6b62\u75db\u548c\u6b23\u5feb\u7684\u9ad8\u5cf0\uff0c\u8fd9\u662f\u7531\u4e8e\u5b83\u53ef\u4ee5\u5728\u5927\u8111\u4e2d\u5bfc\u81f4\u591a\u5df4\u80fa\u7684\u8fc5\u901f\u91ca\u653e\u3002\u800cNKTR-181\u5bfc\u81f4\u591a\u5df4\u80fa\u7684\u91ca\u653e\u8fc7\u7a0b\u66f4\u4e3a\u6f2b\u957f\uff0c\u4ece\u800c\u5728\u6301\u4e45\u6b62\u75db\u7684\u540c\u65f6\u964d\u4f4e\u6b23\u5feb\u611f\u3002\u5728<strong>\u5305\u542b600\u540d\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u5b83\u4e0e\u7f9f\u8003\u916e\u76f8\u6bd4\uff0c\u5bfc\u81f4\u66f4\u5c11\u4e0a\u763e\u73b0\u8c61\u548c\u5176\u5b83\u526f\u4f5c\u7528\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u5b83\u663e\u7136\u662f\u4e00\u79cd\u6709\u6548\u7684\u6b62\u75db\u836f\uff0c\u201d\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u7684\u836f\u7269\u5316\u5b66\u5bb6Steven McKerrall\u5148\u751f\u8bf4\uff1a\u201c\u800c\u4e14\u4ed6\u4eec\u5c06\u7f13\u91ca\u529f\u80fd\u6574\u5408\u5230\u4e86\u836f\u7269\u672c\u8eab\u3002\u201d\u4f46\u662f\u4ed6\u540c\u65f6\u8b66\u544a\u963f\u7247\u4e0a\u763e\u7684\u60a3\u8005\u5df2\u7ecf\u60f3\u51fa\u8fc7\u529e\u6cd5\u6765\u7ed5\u8fc7\u5df2\u6709\u7684\u7f13\u91ca\u914d\u65b9\uff0c\u6bd4\u5982\u538b\u788e\u5e26\u6709\u7f13\u91ca\u5916\u5c42\u7684\u836f\u7247\u3002\u201c\u4e0a\u763e\u7684\u4eba\u603b\u4f1a\u60f3\u51fa\u529e\u6cd5\u6765\u7684\u3002\u201dScripps\u7814\u7a76\u6240\u7684\u751f\u7269\u5316\u5b66\u5bb6Laura Bohn\u5973\u58eb\u8bf4\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">Astraea Therapeutics\u516c\u53f8\u7814\u53d1\u7684\u65b0\u5316\u5408\u7269\u4e0d\u7ed9\u4e0a\u763e\u60a3\u8005\u7834\u574f\u7f13\u91ca\u529f\u80fd\u7684\u673a\u4f1a\u3002<strong>\u8be5\u516c\u53f8\u7684AT-121\u80fd\u591f\u540c\u65f6\u6fc0\u6d3b\u4e24\u79cd\u5927\u8111\u5206\u5b50\uff0c\u9664\u4e86\u6fc0\u6d3bMOR\u4ee5\u5916\uff0c\u5b83\u8fd8\u53ef\u4ee5\u6fc0\u6d3b\u5b64\u5561\u80bd\u963f\u7247\u6837\u53d7\u4f53\uff08nociceptin opioid receptor, NOR\uff09\u3002<\/strong>\u5f53NOR\u5728\u5927\u8111\u4e2d\u88ab\u6fc0\u6d3b\u65f6\uff0c\u5b83\u53ef\u4ee5\u5bf9\u6297MOR\u6fc0\u6d3b\u7684\u6548\u679c\u3002\u540c\u65f6\uff0c\u5b83\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7684\u5176\u5b83\u533a\u57df\u589e\u5f3aMOR\u4ecb\u5bfc\u7684\u6b62\u75db\u6548\u5e94\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537926900.jpg\" alt=\"\u524d\u6cbf | Science\uff1a\u964d\u4f4e\u963f\u7247\u836f\u7269\u4e0a\u763e\u98ce\u9669\u7684\u65b0\u578b\u6b62\u75db\u836f\u6709\u54ea\u4e9b\uff1f\" title=\"\u524d\u6cbf | Science\uff1a\u964d\u4f4e\u963f\u7247\u836f\u7269\u4e0a\u763e\u98ce\u9669\u7684\u65b0\u578b\u6b62\u75db\u836f\u6709\u54ea\u4e9b\uff1f\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u8fd1\u671f\u7684\u300aScience Translational Medicine\u300b\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\u4e2d\uff0cAstraea\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c<strong>\u63a5\u53d7AT-121\u6cbb\u7597\u7684\u7334\u5b50\u83b7\u5f97\u7684\u75bc\u75db\u7f13\u89e3\u662f\u540c\u6837\u5242\u91cf\u5417\u5561\u7684100\u500d\u4ee5\u4e0a<\/strong>\u3002\u800c\u4e14\uff0c\u8fd9\u4e00\u836f\u7269\u6ca1\u6709\u89e6\u53d1\u547c\u5438\u6291\u5236\uff0c\u6210\u763e\u884c\u4e3a\u548c\u5bf9\u836f\u7269\u7684\u8010\u53d7\u53cd\u5e94\u3002AT-121\u8fd8\u53ef\u4ee5\u5bf9\u6297\u7531\u6807\u51c6\u963f\u7247\u7c7b\u836f\u7269\u5bfc\u81f4\u7684\u4e0a\u763e\u3002\u7531\u4e8e\u7f9f\u8003\u916e\u4e0a\u763e\u800c\u81ea\u6211\u670d\u7528\u7f9f\u8003\u916e\u7684\u7334\u5b50\u5728\u63a5\u53d7AT-121\u6cbb\u7597\u4e4b\u540e\uff0c\u7ee7\u7eed\u5bfb\u627e\u7f9f\u8003\u916e\u7684\u6d3b\u52a8\u6025\u5267\u4e0b\u964d\u3002\u201c\u5b9e\u9a8c\u7ed3\u679c\u770b\u8d77\u6765\u975e\u5e38\u6709\u524d\u666f\u3002\u201dBohn\u5973\u58eb\u8bf4\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5b8c\u5168\u907f\u514d\u963f\u7247\u7c7b\u53d7\u4f53\u662f\u53e6\u4e00\u79cd\u5728\u9547\u75db\u540c\u65f6\u964d\u4f4e\u4e0a\u763e\u98ce\u9669\u7684\u7b56\u7565\u3002<\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDA5NTIxNQ==&amp;mid=2649973485&amp;idx=5&amp;sn=c5692645828aa67f35757310dd03d126&amp;chksm=82e9e46db59e6d7bf9f9d06e6becf8eaa40853c62cec976cca7628250650aa0ab00cb755c339&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;font-size: 15px;color: rgb(0, 112, 192);\"><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">Aptinyx<\/span><\/a><span style=\"font-size: 15px;\">\u516c\u53f8\u7814\u53d1\u7684\u4e00\u79cd\u5316\u5408\u7269\u540d\u4e3a<strong>NYX-2925\uff0c\u5b83\u80fd\u591f\u6fc0\u6d3bNMDA\u53d7\u4f53\u3002<\/strong>NMDA\u80fd\u591f\u5e2e\u52a9\u52a0\u5f3a\u4e0e\u5b66\u4e60\u548c\u8bb0\u5fc6\u76f8\u5173\u7684\u795e\u7ecf\u7a81\u89e6\u7684\u5f3a\u5ea6\u3002\u867d\u7136\u6025\u6027\u75bc\u75db\u4e0e\u5b66\u4e60\u6210\u4efd\u65e0\u5173\uff0c\u4f46\u662f\u6162\u6027\u75bc\u75db\u88ab\u8ba4\u4e3a\u4f1a\u5bfc\u81f4\u957f\u671f\u795e\u7ecf\u7ed3\u6784\u53d8\u5316\uff0c\u800c\u8fd9\u79cd\u53d8\u5316\u7684\u4e00\u90e8\u5206\u662f\u7531NMDA\u4ecb\u5bfc\u7684\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5f88\u591a\u4f17\u6240\u5468\u77e5\u7684\u836f\u7269\u80fd\u591f\u963b\u65ad\u8fd9\u4e9b\u53d7\u4f53\uff0c\u4f8b\u5982\u6c2f\u80fa\u916e\u548c\u7f8e\u6c99\u916e\uff0c\u4ed6\u4eec\u5728\u6b62\u75db\u7684\u540c\u65f6\u4e0e\u963f\u7247\u7c7b\u836f\u7269\u76f8\u6bd4\u66f4\u4e0d\u5bb9\u6613\u4e0a\u763e\u3002\u4f46\u662f\u8fd9\u4e9b\u836f\u7269\u4f1a\u5bf9\u5176\u5b83\u9776\u70b9\u4ea7\u751f\u4f5c\u7528\uff0c\u56e0\u6b64\u5e26\u6765\u5176\u5b83\u7684\u526f\u4f5c\u7528\u3002\u6570\u636e\u663e\u793a\uff0c<strong>NYX-2925\u7684\u7279\u5f02\u6027\u66f4\u9ad8\u3002\u5728\u5c0f\u9f20\u548c\u5927\u9f20\u7684\u4e34\u5e8a\u524d\u5b9e\u9a8c\u4e2d\uff0c\u8fd9\u4e00\u5316\u5408\u7269\u53ef\u4ee5\u7f13\u89e3\u75bc\u75db\uff0c\u5e76\u4e14\u5bf9\u4e0e\u5b66\u4e60\u548c\u8bb0\u5fc6\u76f8\u5173\u7684\u795e\u7ecf\u7a81\u89e6\u8fdb\u884c\u91cd\u5851\uff0c\u5c06\u90a3\u4e9b\u5df2\u7ecf\u4e60\u60ef\u4e8e\u75bc\u75db\u7684\u795e\u7ecf\u901a\u8def\u91cd\u65b0\u8fde\u63a5\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5b9e\u9a8c\u7ed3\u679c\u201c\u5f88\u4ee4\u4eba\u5174\u594b\u201d\uff0c\u5b89\u8fdb\uff08Amgen\uff09\u516c\u53f8\u7684\u836f\u7269\u5316\u5b66\u5bb6Ben Milgram\u5148\u751f\u8bf4\u3002Aptinyx\u73b0\u5728\u5728\u4e34\u5e8a2\u671f\u8bd5\u9a8c\u4e2d\u68c0\u9a8cNYX-2959\u5728\u6cbb\u7597\u7cd6\u5c3f\u75c5\u795e\u7ecf\u75db\u548c\u7ea4\u7ef4\u808c\u75db\uff08fibromyalgia\uff09\u60a3\u8005\u65f6\u7684\u7597\u6548\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u8fd9\u4e00\u4f1a\u8bae\u4e2d\u53d1\u5e03\u7684\u5927\u591a\u6570\u7814\u7a76\u53ea\u8fdb\u884c\u8fc7\u52a8\u7269\u5b9e\u9a8c\uff0c\u56e0\u6b64\u8fd9\u4e9b\u5728\u7814\u836f\u7269\u8fd8\u9700\u8981\u8de8\u8d8a\u5f88\u591a\u969c\u788d\u624d\u80fd\u591f\u6210\u4e3a\u83b7\u6279\u836f\u7269\u3002\u7136\u800c\uff0c\u5b83\u4eec\u7ed9\u7814\u7a76\u4eba\u5458\u5e26\u6765\u4e86\u5e0c\u671b\u3002\u201c\u8fd9\u662f\u4ee4\u4eba\u9f13\u821e\u7684\uff0c\u201dBohn\u5973\u58eb\u8bf4\uff1a\u201c\u6211\u4eec\u770b\u5230\u4e86\u63a8\u52a8\u7814\u53d1\u975e\u963f\u7247\u7c7b\u6b62\u75db\u836f\u7684\u5de8\u5927\u529b\u91cf\u3002\u201d<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);font-size: 15px;\">\u70b9\u51fb\u6587\u672b\u201c\u9605\u8bfb\u539f\u6587\u201d\u6216\u201cRead More\u201d\uff0c\u5373\u53ef\u8bbf\u95ee\u539f\u59cb\u8bba\u6587\u9875\u9762\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 15px;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] Service, (2018). New pain drugs may lower overdose and addiction risk. Science, http:\/\/doi.org\/10.1126\/science.361.6405.831<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] Ding, et al., (2018). A bifunctional nociceptin and mu opioid receptor agonist is&nbsp;analgesic&nbsp;without opioid side effects in nonhuman primates. Science Translational Medicine, http:\/\/doi.org\/10.1126\/scitranslmed.aar3483<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"background-color: rgb(255, 255, 255);color: rgb(178, 178, 178);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 10px;letter-spacing: 0.544px;text-align: justify;\">\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><br  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\">\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\u7f16\u8bd1\u6574\u7406\uff08\u6765\u6e90\uff1a\u300a\u79d1\u5b66\u300b\uff09 \u968f\u7740\u963f\u7247\u7c7b\u836f\u7269\u4e0a\u763e\u5371\u673a\u5728\u7f8e\u56fd\u6108\u6f14\u6108\u70c8\uff0c\u79d1\u5b66\u5bb6\u4eec\u548c\u533b\u836f\u516c\u53f8\u4e5f\u52a0\u5927\u4e86\u7814\u53d1\u66f4\u5b89 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":49083,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49082"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=49082"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49082\/revisions"}],"predecessor-version":[{"id":49086,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49082\/revisions\/49086"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/49083"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=49082"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=49082"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=49082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}