{"id":49087,"date":"2018-09-21T01:00:00","date_gmt":"2018-09-26T01:55:02","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e7%9b%98%e7%82%b9-%e4%b8%80%e6%96%87%e7%9c%8b%e6%87%82%e7%b2%be%e5%87%86%e5%8c%bb%e5%ad%a6%e9%a2%86%e5%9f%9f%e5%85%ad%e5%a4%a7%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95%ef%bc%885%ef%bc%89\/"},"modified":"2018-09-26T09:55:03","modified_gmt":"2018-09-26T01:55:03","slug":"%e7%9b%98%e7%82%b9-%e4%b8%80%e6%96%87%e7%9c%8b%e6%87%82%e7%b2%be%e5%87%86%e5%8c%bb%e5%ad%a6%e9%a2%86%e5%9f%9f%e5%85%ad%e5%a4%a7%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95%ef%bc%885%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/49087\/","title":{"rendered":"\u76d8\u70b9 | \u4e00\u6587\u770b\u61c2\u7cbe\u51c6\u533b\u5b66\u9886\u57df\u516d\u5927\u6700\u65b0\u8fdb\u5c55\uff085\uff09"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\"\u76d8\u70b9<\/p>\n

\u56fe\u7247\u6765\u6e90\uff1a123RF<\/span><\/p>\n


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1.\t<\/span>\u7f57\u6c0f\u63a8\u51fa\u4e00\u6b3e\u8f6f\u4ef6\uff0c\u5e2e\u52a9\u60a3\u8005\u7cbe\u51c6\u5339\u914d\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/strong><\/p>\n


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9\u670818\u65e5\uff0c\u7f57\u6c0f\uff08Roche\uff09\u5ba3\u5e03\u63a8\u51fa\u4e00\u6b3e\u5e94\u7528\u7a0b\u5e8f\uff0c\u4f7f\u533b\u751f\u80fd\u591f\u6839\u636e\u60a3\u8005\u7684\u5e74\u9f84\uff0c\u6027\u522b\uff0c\u751f\u7269\u6807\u5fd7\u7269\u548c\u80bf\u7624\u786e\u5b9a\u5408\u9002\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\u3002\u540d\u4e3aNAVIFY\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5339\u914d\u5e94\u7528\u7a0b\u5e8f\uff0c\u53ef\u6839\u636e\u60a3\u8005\u7279\u5b9a\u5c5e\u6027\uff08\u5982\u5e74\u9f84\uff0c\u6027\u522b\uff0c\u751f\u7269\u6807\u5fd7\u7269\u548c\u6765\u81ea11\u4e2a\u56fd\u9645\u6ce8\u518c\u673a\u6784\u7684\u5404\u79cd\u80bf\u7624\u4fe1\u606f\uff09\u9009\u62e9\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5305\u62ec\u5728\u7f8e\u56fdClinicalTrials.gov\uff0c\u5fb7\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\uff08DRKS\uff09\u548c\u6b27\u6d32\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\uff08EUCTR\uff09\u7b49\u673a\u6784\u6ce8\u518c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u53e6\u4e00\u6b3eNAVIFY\u6587\u732e\u641c\u7d22\u5e94\u7528\u7a0b\u5e8f\uff0c\u53ef\u4ee5\u6316\u6398\u5168\u7403\u7684\u6587\u732e\u6765\u6e90\uff08\u5305\u62ecPubMed\uff0c\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff0c\u7f8e\u56fd\u4e2d\u592e\u764c\u75c7\u767b\u8bb0\u5904\u534f\u4f1a\uff09\uff0c\u4ee5\u83b7\u53d6\u6700\u65b0\u7684\u4e34\u5e8a\u548c\u6cbb\u7597\u76f8\u5173\u6587\u732e\u3002\u8fd9\u4e24\u4e2a\u5e94\u7528\u7a0b\u5e8f\u7684\u5185\u5bb9\u7531MolecularMatch\u63d0\u4f9b\uff0c\u8be5\u516c\u53f8\u662f\u4e00\u5bb6\u4e34\u5e8a\u4fe1\u606f\u5b66\u516c\u53f8\uff0c\u62e5\u6709\u7cbe\u51c6\u80bf\u7624\u5b66\uff0c\u514d\u75ab\u7597\u6cd5\u548c\u751f\u7269\u4fe1\u606f\u5b66\u65b9\u9762\u7684\u4e13\u4e1a\u77e5\u8bc6\u3002<\/span><\/p>\n


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\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u5bf9\u4e8e\u836f\u7269\u5f00\u53d1\u8005\u6765\u8bf4\u662f\u4e00\u4e2a\u957f\u671f\u5b58\u5728\u7684\u95ee\u9898\u3002\u7814\u7a76\u8868\u660e\uff0c\u5728\u764c\u75c7\u65b9\u9762\u53ea\u6709\u4e0d\u52305\uff05\u7684\u60a3\u8005\u53c2\u52a0\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7edd\u5927\u591a\u6570\u60a3\u8005\u4ece\u672a\u53c2\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u7684\u539f\u56e0\u6709\u5f88\u591a\u3002\u53c2\u4e0e\u7684\u7b2c\u4e00\u4e2a\u969c\u788d\u5f88\u7b80\u5355\uff1a\u8bb8\u591a\u60a3\u8005\u4e0d\u77e5\u9053\u4e34\u5e8a\u8bd5\u9a8c\u5bf9\u4ed6\u4eec\u5f00\u653e\u3002\u7f57\u6c0f\u5e0c\u671b\u901a\u8fc7\u8ba9\u533b\u751f\u8f7b\u677e\u83b7\u53d6\u4e0e\u60a3\u8005\u76f8\u5173\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ec6\u8282\u6765\u89e3\u51b3\u8fd9\u4e00\u969c\u788d\u3002<\/span><\/p>\n


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2.\t<\/span>Prescient Medicine\u548cMetabiomics\u5408\u4f5c\u5f00\u53d1\u80c3\u80a0\u9053\u57fa\u56e0\u68c0\u6d4b\uff0c\u7b5b\u67e5\u7ed3\u76f4\u80a0\u764c<\/span><\/strong><\/p>\n


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9\u670818\u65e5\uff0cPrescient Medicine\u548cMetabiomics\u5ba3\u5e03\u6210\u7acb\u5408\u8d44\u4f01\u4e1a\uff0c\u5f00\u53d1\u521b\u65b0\u7684\u5fae\u751f\u7269\u7ec4\u8bca\u65ad\u5e73\u53f0\uff0c\u7528\u4e8e\u68c0\u6d4b\u764c\u524d\u7ed3\u80a0\u606f\u8089\u548c\u8bca\u65ad\u5176\u4ed6\u7c7b\u578b\u7684\u80c3\u80a0\u9053\u75be\u75c5\uff0c\u5305\u62ec\u514b\u7f57\u6069\u75c5\uff0c\u7ed3\u80a0\u708e\uff08IBD\uff09\u548c\u80a0\u6613\u6fc0\u7efc\u5408\u5f81\uff08IBS\uff09\u3002\u5408\u4f5c\u76ee\u6807\u662f\u57282020\u5e74\u5b8c\u6210Metabiomics\u521b\u65b0\u5206\u5b50\u6d4b\u8bd5\u89e3\u51b3\u65b9\u6848\u7684\u63a8\u5e7f\u3002\u8fd9\u79cd\u521b\u65b0\u7684\u68c0\u6d4b\u65b9\u6cd5\u91c7\u7528\u4e86Metabiomics\u7684\u4e13\u5229MultiTag\u2122\u65b0\u4e00\u4ee3\u6d4b\u5e8f\uff08NGS\uff09\u6280\u672f\u5206\u6790\u80a0\u9053\u5fae\u751f\u7269DNA\uff0c\u68c0\u6d4b\u7ed3\u80a0\u4e2d\u606f\u8089\u548c\u764c\u53d8\u7684\u9884\u8b66\u4fe1\u53f7\u3002<\/strong>\u8be5\u5408\u4f5c\u6709\u671b\u4e3a\u60a3\u8005\u63d0\u4f9b\u7b80\u5355\u4e14\u5177\u6709\u6210\u672c\u6548\u76ca\u7684\u7cbe\u51c6\u533b\u5b66\u5206\u5b50\u8bca\u65ad\u89e3\u51b3\u65b9\u6848\u3002<\/span><\/p>\n


<\/p>\n

3.\t<\/span>Incyte\u548cFoundation Medicine\u5408\u4f5c\uff0c\u5f00\u53d1FGFR\u6291\u5236\u5242Pemigatinib\u7684\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1<\/span><\/strong><\/p>\n


<\/p>\n

9\u670811\u65e5\uff0cIncyte\u548cFoundation Medicine\u5ba3\u5e03\u5df2\u8fbe\u6210\u4f34\u968f\u8bca\u65ad\uff08CDx\uff09\u8bd5\u5242\u7684\u5f00\u53d1\u3001\u76d1\u7ba1\u548c\u63a8\u5e7f\u5408\u4f5c\uff0c\u4e13\u6ce8\u4e8e\u80c6\u56ca\u764c\u836f\u7269pemigatinib\uff08INCB54828\uff09\u7684CDx\u5f00\u53d1\u3002Pemigatinib\u662fIncyte\u6b63\u5728\u5f00\u53d1\u7684\u4e00\u79cdFGFR 1\/2\/3\u7684\u9009\u62e9\u6027\u53e3\u670d\u6291\u5236\u5242\u3002<\/strong>\u53cc\u65b9\u5c06\u57fa\u4e8eFDA\u6279\u51c6\u7684\u5168\u57fa\u56e0\u7ec4\u5206\u6790\uff08CGP\uff09\u4ea7\u54c1FoundationOne\u00ae CDx\uff0c\u5f00\u53d1\u80fd\u68c0\u6d4bFGFR2\u6613\u4f4d\u7684\u4f34\u968f\u8bca\u65ad\u65b9\u6cd5\u3002FoundationOne\u00ae CDx\u662f\u57fa\u4e8e\u4e8c\u4ee3\u6d4b\u5e8f\u6280\u672f\u7684\u4f53\u5916\u8bca\u65ad\u4ea7\u54c1\uff0c\u53ef\u4ee5\u68c0\u6d4b\u591a\u8fbe324\u4e2a\u57fa\u56e0\u7684\u7a81\u53d8\u60c5\u51b5\u3002\u8fd9\u9879\u5408\u4f5c\u6709\u671b\u4e3a\u764c\u75c7\u60a3\u8005\u5e26\u6765\u751f\u7269\u6807\u5fd7\u7269\u9a71\u52a8\u7684\u7597\u6cd5\u3002<\/span><\/p>\n


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4.\t<\/span>BMS\u4e0eNatera\u8fbe\u6210\u5408\u4f5c\uff0c\u901a\u8fc7\u6db2\u4f53\u6d3b\u68c0\u53d1\u73b0Opdivo\u7684\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269<\/span><\/strong><\/p>\n


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9\u670813\u65e5\uff0c\u4e13\u6ce8\u4e8e\u6e38\u79bb\u7ec6\u80deDNA\u68c0\u6d4b\u7684Natera\u516c\u53f8\u5ba3\u5e03\u4e0e\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08Bristol-Myers Squibb\uff09\u8fbe\u6210\u534f\u8bae\uff0c\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u76842\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u4f7f\u7528Natera\u7684Signatera\u2122\u5b9a\u5236\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u6d4b\u8bd5<\/strong>\u3002\u8be5\u7814\u7a76\u5c06\u4f7f\u7528\u6db2\u4f53\u6d3b\u68c0\u65b9\u6cd5Signatera\u2122\u7b5b\u9009\u624b\u672f\u5207\u9664\u540e\u5177\u6709\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u7684\u60a3\u8005\uff0c\u4f5c\u4e3a\u662f\u5426\u63a5\u53d7Opdivo\uff08nivolumab\uff09\u4f5c\u4e3a\u8f85\u52a9\u6807\u51c6\u6cbb\u7597\u7684\u5224\u65ad\u4f9d\u636e\uff0c\u9884\u8ba1\u7b2c1\u4f4d\u60a3\u8005\u5c06\u4e8e2019\u5e74\u5165\u7ec4\u3002\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0cSignatera\u2122\u80fd\u591f\u68c0\u6d4b\u6b8b\u7559\u75c5\u7076\uff0c\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\uff0c\u5e76\u4e14\u6bd4\u65e9\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6807\u51c6\u8bca\u7597\u65b9\u6cd5\u65e911\u4e2a\u6708\u8bc6\u522b\u590d\u53d1\uff0c\u7075\u654f\u5ea6\u4e3a93\uff05\uff0c\u5047\u9633\u6027\u7387\u4e3a0\u3002<\/span><\/p>\n


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5.\t<\/span>MRM Proteomics\u548cExactis\u5f00\u5c55\u7cbe\u51c6\u533b\u5b66\u5408\u4f5c\uff0c\u5206\u6790\u764c\u75c7\u7684\u86cb\u767d\u8d28\u751f\u7269\u6807\u5fd7\u7269<\/span><\/strong><\/p>\n


<\/p>\n

9\u670812\u65e5\uff0cMRM Proteomics\u4e0eExactis Innovation\u5ba3\u5e03\u5408\u4f5c\uff0c\u5f00\u53d1\u548c\u9a8c\u8bc1\u4e34\u5e8a\u86cb\u767d\u8d28\u7ec4\u5b66\u6d4b\u8bd5\uff0c\u4e3a\u4e34\u5e8a\u533b\u751f\u548c\u79d1\u5b66\u5bb6\u63d0\u4f9b\u8bc6\u522b\u514d\u75ab\u7279\u5f81\u548c\u80bf\u7624\u7a81\u53d8\u7279\u5f81\u7684\u65b9\u6cd5\uff0c\u4ee5\u4fbf\u66f4\u597d\u5730\u4e3a\u60a3\u8005\u5339\u914d\u6709\u6548\u7684\u6cbb\u7597\u3002\u65b0\u7684\u8bca\u65ad\u6d4b\u8bd5\u5c06\u662f\u7b2c\u4e00\u4e2a\u6d4b\u91cf\u591a\u79cd\u764c\u75c7\u76f8\u5173\u86cb\u767d\u6d3b\u6027\u7684\u514d\u75abMALDI\u6d4b\u8bd5\u3002\u8fd9\u79cd\u65b9\u6cd5\u6709\u53ef\u80fd\u901a\u8fc7\u76f4\u63a5\u5728\u5355\u4e2a\u60a3\u8005\u5c42\u9762\u4e86\u89e3\u75be\u75c5\u8fdb\u5c55\u7684\u673a\u5236\u548c\u9002\u5f53\u836f\u7269\u76ee\u6807\uff0c\u4ece\u800c\u6539\u53d8\u764c\u75c7\u6cbb\u7597\u7684\u9009\u62e9\u3002<\/strong>\u901a\u8fc7\u5408\u4f5c\uff0cMRM Proteomics\u5c06\u4f7f\u7528\u5176\u4e13\u6709\u7684immunMALDI\u6280\u672f\u5206\u6790Exactis\u7684\u201cPersonalize My Treatment\u201d\u60a3\u8005\u767b\u8bb0\u83b7\u5f97\u7684\u4e73\u817a\u764c\u548c\u7ed3\u80a0\u76f4\u80a0\u764c\u6837\u672c\u3002\u4e00\u65e6\u6d4b\u8bd5\u65b9\u6cd5\u7ecf\u8fc7\u9a8c\u8bc1\uff0c\u8fd9\u9879\u6d4b\u8bd5\u5c06\u7528\u4e8e\u4e34\u5e8a\u8868\u5f81\u514d\u75ab\u7279\u5f81\u548c\u80bf\u7624\u7a81\u53d8\u7279\u5f81\uff0c\u7b5b\u9009\u5bf9\u514d\u75ab\u80bf\u7624\u5b66\u764c\u75c7\u6cbb\u7597\u6709\u53cd\u5e94\u7684\u60a3\u8005\u3002<\/span><\/p>\n


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6.\t<\/span>Tempus\u5b8c\u62101.1\u4ebf\u7f8e\u5143E\u8f6e\u878d\u8d44\uff0c\u52a0\u901f\u7cbe\u51c6\u533b\u5b66\u4e1a\u52a1<\/span><\/strong><\/p>\n


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8\u670829\u65e5\uff0c\u4f4d\u4e8e\u829d\u52a0\u54e5\u7684Tempus\u516c\u53f8\u5ba3\u5e03\u5b8c\u62101.1\u4ebf\u7f8e\u5143\u7684E\u8f6e\u878d\u8d44\uff0c\u5c06\u8be5\u516c\u53f8\u4f30\u503c\u63d0\u5347\u523020\u4ebf\u7f8e\u5143\u3002\u6b64\u6b21\u878d\u8d44\u7684\u6295\u8d44\u65b9\u5305\u62ecBaillie Gifford, T. Rowe Price, Revolution Growth, New Enterprise Associates \u548c\u5176\u5b83\u5df2\u6709\u6295\u8d44\u8005\u3002Tempus\u662f\u4e00\u5bb6\u901a\u8fc7\u6536\u96c6\u548c\u5206\u6790\u5206\u5b50\u751f\u7269\u5b66\u548c\u4e34\u5e8a\u6570\u636e\uff0c\u81f4\u529b\u4e8e\u6539\u5584\u764c\u75c7\u7597\u6cd5\u7684\u7cbe\u51c6\u533b\u7597\u79d1\u6280\u516c\u53f8\u3002\u672c\u8f6e\u878d\u8d44\u83b7\u5f97\u7684\u8d44\u91d1\u5c06\u7528\u4e8e\u5411\u5305\u62ec\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u7cd6\u5c3f\u75c5\u7684\u5176\u5b83\u533b\u7597\u9886\u57df\u6269\u5c55\u516c\u53f8\u670d\u52a1\uff0c\u5e76\u4e14\u5c06\u516c\u53f8\u7684\u4e1a\u52a1\u5168\u7403\u5316\u3002\u8be5\u516c\u53f8\u4f7f\u7528\u673a\u5668\u5b66\u4e60\uff0c\u65b0\u4e00\u4ee3\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff0c\u548cAI\u8f85\u52a9\u7684\u56fe\u50cf\u8bc6\u522b\u6280\u672f\u6765\u66f4\u597d\u5730\u4e86\u89e3\u60a3\u8005\u80bf\u7624\u7684\u7279\u5f81\uff0c\u4ece\u800c\u4e3a\u60a3\u8005\u63d0\u4f9b\u201c\u91cf\u8eab\u5b9a\u505a\u201d\u7684\u6700\u4f73\u7597\u6cd5\u9009\u62e9<\/strong>\u3002\u5728\u77ed\u77ed3\u5e74\u91cc\uff0c\u8be5\u516c\u53f8\u5df2\u7ecf\u5efa\u7acb\u8d77\u884c\u4e1a\u4e2d\u6700\u5168\u9762\u7684\u6570\u636e\u5e93\u4e4b\u4e00\u3002\u76ee\u524d\uff0cTempus\u516c\u53f8\u7684\u6280\u672f\u5e73\u53f0\u89e6\u53ca\u4e86\u7f8e\u56fd\u63a5\u8fd1\u56db\u5206\u4e4b\u4e00\u7684\u764c\u75c7\u60a3\u8005\u3002<\/span><\/p>\n


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[1] \t<\/span>Roche\u2019s NAVIFY decision support portfolio unlocks relevant content from clinical trial and medical publication databases. Retrieved Sep 18, 2018, from https:\/\/www.roche.com\/media\/releases\/med-cor-2018-09-18.htm <\/span><\/p>\n

[2] \t<\/span>Roche tackles clinical trial matching challenge. Retrieved Sep 18, 2018, from https:\/\/www.fiercebiotech.com\/biotech\/roche-tackles-clinical-trial-matching-challenge <\/span><\/p>\n

[3] \t<\/span>Prescient Medicine and Metabiomics Partner to Develop New Gastrointestinal Health Tests to Detect Polyps, Prevent Colon Cancer. Retrieved Sep 18, 2018, from  https:\/\/www.prnewswire.com\/news-releases\/prescient-medicine-and-metabiomics-partner-to-develop-new-gastrointestinal-health-tests-to-detect-polyps-prevent-colon-cancer-300714306.html<\/span><\/p>\n

[4] \t<\/span>Tempus Announces $110 Million in Series E Financing. Retrieved August 29, 2018, from https:\/\/globenewswire.com\/news-release\/2018\/08\/29\/1558390\/0\/en\/Tempus-Announces-110-Million-in-Series-E-Financing.html<\/span><\/p>\n

[5] \t<\/span>Incyte and Foundation Medicine Announce Agreement to Develop Companion Diagnostic for Pemigatinib (INCB54828), a Selective FGFR Inhibitor, in Patients with Cholangiocarcinoma. Retrieved Sep 11, 2018, from https:\/\/www.businesswire.com\/news\/home\/20180911005165\/en\/Incyte-Foundation-Medicine-Announce-Agreement-Develop-Companion<\/span><\/p>\n

[6] \t<\/span>MRM Proteomics Inc and Exactis Innovation Partner to Establish Unique Clinical Proteomics Tools for Precision Medicine. Retrieved Sep 12, 2018, from https:\/\/www.businesswire.com\/news\/home\/20180912005976\/en\/<\/span><\/p>\n

[7] \t<\/span>Natera Signs Agreement with Bristol-Myers Squibb to Investigate Signatera\u2122 ctDNA Assay as a Potential Biomarker for Opdivo (nivolumab) in a Prospective Phase 2 Adjuvant Non-Small Cell Lung Cancer Clinical Trial. Retrieved Sep 13, 2018, from https:\/\/www.prnewswire.com\/news-releases\/natera-signs-agreement-with-bristol-myers-squibb-to-investigate-signatera-ctdna-assay-as-a-potential-biomarker-for-opdivo-nivolumab-in-a-prospective-phase-2-adjuvant-non-small-cell-lung-cancer-clinical-trial-300712311.html<\/span><\/p>\n


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