{"id":49148,"date":"2018-09-18T01:00:00","date_gmt":"2018-09-26T01:55:47","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e9%80%9f%e9%80%92-%e9%99%8d%e4%bd%8e%e6%82%a3%e8%80%85%e6%81%b6%e5%8c%96%e9%a3%8e%e9%99%a9%ef%bc%8ccopd%e6%96%b0%e7%96%97%e6%b3%95%e6%9c%89%e6%9c%9b%e5%b9%b4%e5%ba%95%e8%8e%b7%e6%89%b9\/"},"modified":"2018-09-26T09:55:49","modified_gmt":"2018-09-26T01:55:49","slug":"%e9%80%9f%e9%80%92-%e9%99%8d%e4%bd%8e%e6%82%a3%e8%80%85%e6%81%b6%e5%8c%96%e9%a3%8e%e9%99%a9%ef%bc%8ccopd%e6%96%b0%e7%96%97%e6%b3%95%e6%9c%89%e6%9c%9b%e5%b9%b4%e5%ba%95%e8%8e%b7%e6%89%b9","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/49148\/","title":{"rendered":"\u901f\u9012 | \u964d\u4f4e\u60a3\u8005\u6076\u5316\u98ce\u9669\uff0cCOPD\u65b0\u7597\u6cd5\u6709\u671b\u5e74\u5e95\u83b7\u6279"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/p>\n


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\u4eca\u65e5\uff0cTheravance Biopharma\u516c\u53f8\u4e0eMylan\u516c\u53f8\uff0c\u5ba3\u5e03\u4e86\u5176\u5438\u5165\u5f0f\u7597\u6cd5Yupelri\uff08revefenacin\uff09\uff0c\u5728\u4e34\u5e8a3\u671f\u8bd5\u9a8c\u4e2d\u7684\u6700\u65b0\u79ef\u6781\u6570\u636e\u3002\u8bd5\u9a8c\u6570\u636e\u663e\u793a\uff0c\u8be5\u9488\u5bf9\u6162\u6027\u963b\u585e\u6027\u80ba\u75be\u75c5\uff08COPD\uff09\u7684\u7597\u6cd5\uff0c\u53ef\u4ee5\u6709\u6548\u5e2e\u52a9\u4e2d\u5ea6\u81f3\u6781\u91cd\u5ea6COPD\u60a3\u8005\u5c06\u6076\u5316\u98ce\u9669\u964d\u4f4e15%-18%\u3002<\/strong>\u5728\u7b2c52\u5468\uff0c\u6bcf\u65e5\u63a5\u53d7\u4e00\u6b21Yupelri<\/span>\u6cbb\u7597\u7684\u60a3\u8005\u7ec4\u663e\u793a\u51fa\u4e86\u4f18\u4e8e\u5b89\u6170\u5242\u7ec4\u548ctiotropium\u7ec4\u7684\u826f\u597d\u7ed3\u679c\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

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COPD\u662f\u4e00\u79cd\u53d1\u75c5\u7387\u6b63\u5728\u63d0\u5347\u7684\u4e25\u91cd\u75be\u75c5\uff0c\u662f\u7f8e\u56fd\u6392\u540d\u7b2c\u4e09\u7684\u7684\u81f4\u6b7b\u75c5\u56e0\uff0c\u5168\u7f8e\u6709\u5c06\u8fd11570\u4e07\u540d\u786e\u8bca\u60a3\u8005\uff0c\u5360\u5168\u90e8\u4eba\u53e3\u76846.4%\u3002\u4ec52010\u5e74\u4e00\u5e74\u5185\u5c31\u6709\u8d85\u8fc770\u4e07\u60a3\u8005\u56e0COPD\u4f4f\u9662\u30022010\u5e74\u5168\u7f8e\u7684COPD\u76f8\u5173\u5f00\u9500\u4e5f\u9ad8\u8fbe500\u4ebf\u7f8e\u5143\uff0c\u5305\u62ec295\u4ebf\u7f8e\u5143\u7684\u76f4\u63a5\u533b\u7597\u5f00\u9500\uff0c80\u4ebf\u7f8e\u5143\u7684\u95f4\u63a5\u53d1\u75c5\u5f00\u9500\u4ee5\u53ca124\u4ebf\u7f8e\u5143\u7684\u95f4\u63a5\u6b7b\u4ea1\u5f00\u9500\u3002\u5982\u6b64\u4e25\u5cfb\u7684\u75be\u75c5\u73b0\u72b6\u4f7f\u5f97\u60a3\u8005\u4eec\u6025\u9700\u4e00\u6b3e\u6709\u6548\u7684\u836f\u7269\u6765\u5e2e\u52a9\u4ed6\u4eec\u964d\u4f4eCOPD\u5e26\u6765\u7684\u5371\u9669\u3002<\/span>
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Yupelri<\/span>\u662f\u4e00\u6b3e\u5728\u7814\u7684\u521b\u65b0\u957f\u6548\u6bd2\u8548\u78b1\u62ee\u6297\u5242\uff08LAMA\uff09\u5438\u5165\u5f0f\u7597\u6cd5\uff0c\u5176\u9488\u5bf9\u4e2d\u5ea6\u81f3\u91cd\u5ea6COPD\u7684\u65b0\u836f\u7533\u8bf7\u76ee\u524d\u6b63\u5728\u63a5\u53d7FDA\u7684\u5ba1\u8bc4\uff0c\u9884\u8ba1\u76ee\u6807\u6279\u51c6\u65e5\u671f\uff08PDUFA\uff09\u4e3a2018\u5e7411\u670813\u65e5\u3002\u5982\u679c\u5ba1\u8bc4\u901a\u8fc7\uff0cYupelri<\/span>\u5c06\u6210\u4e3a\u9996\u6b3e\u9488\u5bf9COPD\u7684\u6bcf\u65e5\u4e00\u6b21\u957f\u6548\u96fe\u5316\u652f\u6c14\u7ba1\u6269\u5f20\u5242\uff0c\u5e76\u53ef\u4ee5\u4e0e\u5e02\u9762\u4e0a\u4efb\u4e00\u6b3e\u6807\u51c6\u55b7\u5c04\u5f0f\u96fe\u5316\u5668\u517c\u5bb9\u3002<\/strong>\u9664\u6b64\u4e4b\u5916\uff0cYupelri<\/span>\u5728\u5b9a\u91cf\u96fe\u5316\u5438\u5165\u5668\u548c\u5e72\u7c89\u5438\u5165\u5668\u4e0a\u7684\u5e94\u7528\u6548\u679c\u5747\u4e3a\u7a33\u5b9a\u826f\u597d\uff0c\u8bc1\u660eLAMA\u4e0d\u4ec5\u53ef\u4ee5\u4f5c\u4e3aCOPD\u6301\u7eed\u6027\u7597\u6cd5\u7684\u4e2d\u575a\u529b\u91cf\uff0c\u4e5f\u6709\u671b\u6210\u4e3a\u65b0\u4e00\u4ee3\u624b\u6301\u578b\u590d\u5408\u836f\u7269\u7814\u53d1\u7684\u575a\u5b9e\u57fa\u7840\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

<\/span>\u25b2COPD\u6cbb\u7597\u4eea\u5668\uff08\u56fe\u7247\u6765\u6e90\uff1aMylan\u516c\u53f8\u5b98\u7f51\uff09<\/strong><\/span><\/strong><\/p>\n


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\u6b64\u6b21\u516c\u5e03\u7684\u7ed3\u679c\u5305\u62ec\u4e24\u9879\u957f\u8fbe12\u5468\u7684\u968f\u673a\u53cc\u76f2\uff0c\u5b89\u6170\u5242\u5bf9\u7167\u7684\u5e73\u884c\u5173\u952e3\u671f\u8bd5\u9a8c\uff0c\u5171\u5305\u542b1229\u540d\u4e2d\u5ea6\u81f3\u6781\u91cd\u5ea6COPD\u60a3\u8005\u3002\u8bd5\u9a8c\u6570\u636e\u8868\u660e\uff0c\u6bcf\u65e5\u4e00\u6b21175 mcg Yupelri<\/span>\u60a3\u8005\u7ec4\u7684\u5e73\u5747\u5e74\u6076\u5316\u7387\u4e3a0.47\uff0c\u6bcf\u65e5\u4e00\u6b2188 mcg Yupelri\u60a3\u8005\u7ec4\u4e3a0.45\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76840.55\u76f8\u6bd4\uff0c\u5206\u522b\u964d\u4f4e\u4e8615%\u548c18%\u3002<\/strong><\/span><\/p>\n


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\u9664\u6b64\u4e4b\u5916\uff0c\u957f\u8fbe12\u4e2a\u6708\u76843\u671f\u5b89\u5168\u6027\u8bd5\u9a8c\u5305\u542b\u4e861055\u540d\u4e2d\u5ea6\u81f3\u6781\u91cd\u5ea6COPD\u60a3\u8005\u3002\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\u6bcf\u65e5\u4e00\u6b21175 mcg Yupelri<\/span>\u60a3\u8005\u7ec4\u7684\u5e73\u5747\u5e74\u6076\u5316\u7387\u4e3a0.38\uff0c\u6bcf\u65e5\u4e00\u6b2188 mcg Yupelri<\/span>\u60a3\u8005\u7ec4\u4e3a0.57\uff0c\u800c\u6bcf\u65e5\u4e00\u6b2118 mcg tiotropium\u60a3\u8005\u7ec4\u4e3a0.46\u3002\u663e\u793a\u51fa\u6bcf\u65e5\u4e00\u6b21175 mcg Yupelri<\/span>\u5bf9\u6bd4tiotropium\u53ef\u4ee5\u5c06COPD\u6076\u5316\u7387\u964d\u4f4e17%\u3002<\/strong><\/span><\/p>\n


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\u201c\u5728\u6210\u529f\u5b8c\u6210Yupelri<\/span>\u7684\u5927\u578b3\u671f\u4e34\u5e8a\u9879\u76ee\u540e\uff0c\u6211\u4eec\u5f88\u9ad8\u5174\u53ef\u4ee5\u7ee7\u7eed\u9488\u5bf9\u5176\u6570\u636e\u8fdb\u884c\u5ef6\u5c55\u6027\u7814\u7a76\uff0c\u5bfb\u627e\u5176\u4ed6\u6709\u610f\u4e49\u7684\u53ef\u53d1\u5c55\u65b9\u5411\uff0c\u6bd4\u5982\u964d\u4f4eCOPD\u7684\u6076\u5316\u7387\u3002\u5c3d\u7ba1\u73b0\u6709\u7684\u4e8b\u540e\u5206\u6790\u7ed3\u679c\u6ca1\u6709\u8fbe\u5230\u7edf\u8ba1\u610f\u4e49\u4e0a\u7684\u663e\u8457\u533a\u522b\uff0c\u4f46\u662f\u4e0e\u5b89\u6170\u5242\u548ctiotropium\u4f5c\u6bd4\u8f83\uff0c\u6bcf\u65e5175 mcg Yupelri<\/span>\u8868\u73b0\u51fa\u53ef\u4ee5\u5c06COPD\u6076\u5316\u7387\u964d\u4f4e>15%\u7684\u8d8b\u52bf\uff0c\u201d\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u6559\u5802\u5c71\u5206\u6821\u533b\u5b66\u6559\u6388\uff0c\u517c\u7814\u7a76\u62a5\u544a\u7b2c\u4e00\u4f5c\u8005James F. Donohue\u535a\u58eb\u5728ERS\u5927\u4f1a\u4e0a\u8bf4\uff1a\u201c\u4f5c\u4e3a\u5de5\u4f5c\u5728\u7b2c\u4e00\u7ebf\u7684\u4e34\u5e8a\u533b\u751f\uff0c\u6211\u6df1\u77e5COPD\u6076\u5316\u5bf9\u60a3\u8005\u7684\u5065\u5eb7\u548c\u6b63\u5e38\u751f\u6d3b\u6709\u957f\u671f\u7684\u6076\u6027\u5f71\u54cd\u3002\u8fd9\u6b21\u516c\u5e03\u7684\u79ef\u6781\u6570\u636e\u7ed9\u6211\u4eec\u5e26\u6765\u4e86\u6781\u5927\u7684\u9f13\u821e\uff0c\u4e3a\u6211\u4eec\u8fdb\u4e00\u6b65\u8bc4\u4f30Yupelri\u5bf9COPD\u6076\u5316\u7387\u7684\u5f71\u54cd\u63d0\u4f9b\u575a\u5b9e\u7684\u7406\u8bba\u57fa\u7840\u3002\u201d<\/span><\/p>\n


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\u201c\u6211\u4eec\u5bf9\u672c\u6b213\u671f\u9879\u76ee\u7684\u6210\u529f\u53caYupelri<\/span>\u9488\u5bf9COPD\u6076\u5316\u7387\u7684\u672a\u6765\u53d1\u5c55\u6f5c\u529b\u611f\u5230\u975e\u5e38\u9a84\u50b2\uff0c\u201dTheravance\u516c\u53f8\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98Rick E Winningham\u5148\u751f\u8bf4\uff1a\u201c\u5373\u4f7f\u8fd8\u672a\u83b7\u5f97FDA\u7684\u6279\u51c6\uff0c\u6211\u4eec\u4e5f\u53ef\u4ee5\u51ed\u501f\u672c\u6b21\u5f97\u5230\u7684\u6570\u636e\u5bf9Yupelri<\/span>\u7684\u6cbb\u7597\u6f5c\u529b\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\u3002\u6211\u4eec\u4e0e\u5408\u4f5c\u4f19\u4f34Mylan\u516c\u53f8\u90fd\u575a\u4fe1\u8be5\u836f\u6709\u671b\u6210\u4e3aCOPD\u60a3\u8005\u53ef\u9009\u62e9\u7684\u6bcf\u65e5\u4e00\u6b21\u96fe\u5316\u652f\u6c14\u7ba1\u6269\u5f20\u5242\u7684\u91cd\u8981\u7597\u6cd5\u3002\u201d<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

\u25b2Mylan\u516c\u53f8\u603b\u88c1Rajiv Malik\u5148\u751f\uff08\u56fe\u7247\u6765\u6e90\uff1aMylan\u516c\u53f8\u5b98\u7f51\uff09<\/strong><\/span><\/strong><\/p>\n


<\/strong><\/span><\/strong><\/p>\n

Mylan\u516c\u53f8\u603b\u88c1Rajiv Malik\u5148\u751f\u8bf4\uff1a\u201c\u6700\u65b0\u7684\u6570\u636e\u663e\u793a\u4e86\u6211\u4eec\u5728\u4e34\u5e8a\u9879\u76ee\u4e0a\u7684\u4e0d\u61c8\u52aa\u529b\u83b7\u5f97\u4e86\u6210\u679c\u3002\u6211\u4eec\u5bf9\u4e8e\u672c\u6b21\u80fd\u5728ERS\u5927\u4f1a\u4e0a\u53d1\u8868\u8fd9\u4e9b\u6570\u636e\u8868\u793a\u5341\u5206\u9a84\u50b2\uff0c\u5e76\u671f\u5f85\u4e0eTheravance\u53caFDA\u7ee7\u7eed\u5408\u4f5c\uff0c\u63a8\u8fdb\u8fd9\u4e00\u91cd\u8981\u7597\u6cd5\u7684\u53d1\u5c55\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u798f\u97f3\u201d\u3002<\/span><\/p>\n


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[1] Theravance Biopharma and Mylan Report New Data from Phase 3 Studies of YUPELRI\u2122 (revefenacin) in Oral Presentation at the European Respiratory Society International Congress. Retrieved September 17, 2018, from https:\/\/www.biospace.com\/article\/releases\/theravance-biopharma-and-mylan-report-new-data-from-phase-3-studies-of-yupelri-revefenacin-in-oral-presentation-at-the-european-respiratory-society-international-congress\/<\/span><\/p>\n

[2] \u591a\u9879\u4e34\u5e8a\u7ed3\u679c\u51fa\u7089\uff0c\u7f8e\u56fd\u80f8\u79d1\u5b66\u4f1a\u56fd\u9645\u4f1a\u8bae\u65b0\u95fb\u6c47\u603b. Retrieved September 17, 2018, from https:\/\/mp.weixin.qq.com\/s\/iB5hFt-lGSDzxz_EA2r8gQ<\/span><\/p>\n


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\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


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