{"id":49159,"date":"2018-09-18T01:00:00","date_gmt":"2018-09-26T01:55:55","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e7%9b%98%e7%82%b9-%e4%b8%80%e6%96%87%e7%9c%8b%e6%87%82%e8%82%bf%e7%98%a4%e9%9d%b6%e5%90%91%e7%96%97%e6%b3%95%e4%ba%94%e5%a4%a7%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95%ef%bc%88%e7%ac%ac8%e6%9c%9f\/"},"modified":"2018-09-26T09:55:56","modified_gmt":"2018-09-26T01:55:56","slug":"%e7%9b%98%e7%82%b9-%e4%b8%80%e6%96%87%e7%9c%8b%e6%87%82%e8%82%bf%e7%98%a4%e9%9d%b6%e5%90%91%e7%96%97%e6%b3%95%e4%ba%94%e5%a4%a7%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95%ef%bc%88%e7%ac%ac8%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/49159\/","title":{"rendered":"\u76d8\u70b9 | \u4e00\u6587\u770b\u61c2\u80bf\u7624\u9776\u5411\u7597\u6cd5\u4e94\u5927\u6700\u65b0\u8fdb\u5c55\uff08\u7b2c8\u671f\uff09"},"content":{"rendered":"
\n

\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\"\u76d8\u70b9<\/p>\n

<\/span><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/strong><\/strong>\u56fe\u7247\u6765\u6e90\uff1a123RF<\/span><\/p>\n


<\/p>\n

1.\t<\/span>\u536b\u6750\u548c\u9ed8\u6c99\u4e1c\u5ba3\u5e03\u4e50\u536b\u739b\u00ae\uff08\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09\u5728\u4e2d\u56fd\u83b7\u6279\u6cbb\u7597\u809d\u764c<\/span><\/strong><\/span><\/p>\n


<\/p>\n

2018\u5e749\u67085\u65e5\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08Eisai\uff0c\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u548c\u9ed8\u6c99\u4e1c\uff08MSD\uff09\u516c\u53f8\u5ba3\u5e03\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5df2\u6279\u51c6\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u4e50\u536b\u739b\u00ae\uff08\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09\u5355\u836f\uff0c\u5728\u4e2d\u56fd\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u809d\u764c\u60a3\u8005<\/strong>\u3002\u4e2d\u56fd\u662f\u5168\u4e16\u754c\u809d\u764c\u60a3\u8005\u6700\u591a\u7684\u56fd\u5bb6\uff0c\u6b64\u6b21\u6279\u51c6\u6807\u5fd7\u7740\u4e50\u536b\u739b\u00ae\u5c06\u9996\u6b21\u8fdb\u5165\u4e2d\u56fd\uff0c\u662f\u5341\u5e74\u6765\u7b2c\u4e00\u4e2a\u5728\u4e2d\u56fd\u88ab\u6279\u51c6\u4f5c\u4e3a\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u4e00\u7ebf\u7cfb\u7edf\u7597\u6cd5\u7684\u65b0\u6cbb\u7597\u65b9\u6848\u3002\u81ea\u9996\u6b21\u4e0a\u5e02\u4ee5\u6765\uff0c\u5df2\u6709\u8d85\u8fc710000\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u4e50\u536b\u739b\u00ae\u6cbb\u7597\u3002\u76ee\u524d\uff0c\u4e50\u536b\u739b\u00ae\u5df2\u5728\u7f8e\u56fd\u3001\u65e5\u672c\u3001\u6b27\u6d32\u548c\u4e9a\u6d32\u7684\u591a\u4e2a\u56fd\u5bb6\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u96be\u6cbb\u6027\u7532\u72b6\u817a\u764c\uff0c\u5e76\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u7684\u591a\u4e2a\u56fd\u5bb6\u83b7\u6279\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u7528\u4e8e\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u7684\u4e8c\u7ebf\u6cbb\u7597\u3002\u5bf9\u4e8e\u809d\u7ec6\u80de\u764c\uff0c\u4e50\u536b\u739b\u00ae\u57282018\u5e743\u6708\u5728\u65e5\u672c\u83b7\u6279\u8be5\u9002\u5e94\u75c7\uff0c2018\u5e748\u6708\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u83b7\u6279\u8be5\u9002\u5e94\u75c7\u3002<\/span><\/p>\n


<\/p>\n

2.\t<\/span>\u6cbb\u7597\u590d\u53d1\u6027\u8111\u7624\uff0cSTAT3\u9776\u5411\u65b0\u836f\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/strong><\/span><\/p>\n


<\/p>\n

9\u670817\u65e5\uff0cMoleculin Biotech\u516c\u53f8\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u7684\u201cfirst-in-class\u201d\u6297\u764c\u5019\u9009\u836f\u7269\u8fdb\u5165\u6cbb\u7597\u590d\u53d1\u6027\u8111\u7624\u60a3\u8005\u7684\u4e34\u5e8a1\u671f\u8bd5\u9a8c\u3002\u8fd9\u4e00\u79f0\u4e3aWP1066\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u80fd\u591f\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u6291\u5236\u91cd\u8981\u4fe1\u53f7\u4f20\u5bfc\u86cb\u767dSTAT3\u7684\u6d3b\u6027\uff0c\u5e76\u4e14\u540c\u65f6\u523a\u6fc0\u514d\u75ab\u53cd\u5e94\u3002WP1066\u80fd\u591f\u7a7f\u8d8a\u8840\u8111\u5c4f\u969c\uff0c\u5728\u4e34\u5e8a1\u671f\u8bd5\u9a8c\u4e2d\u5c06\u7528\u4e8e\u6cbb\u7597\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7b49\u590d\u53d1\u6027\u8111\u7624\u60a3\u8005\u3002<\/span><\/p>\n


<\/span><\/p>\n

WP1066\u662f\u57fa\u4e8e\u8702\u80f6\u4e2d\u7684\u4e00\u79cd\u5929\u7136\u6d3b\u6027\u6210\u4efd\u7684\u5316\u5b66\u9aa8\u67b6\uff0c\u7531\u5fb7\u514b\u8428\u65af\u5927\u5b66MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u7684Waldemar Priebe\u6559\u6388\u7814\u53d1\u7684\u4e00\u6b3e\u76f4\u63a5\u6291\u5236STAT3\u6d3b\u6027\u7684\u6297\u764c\u836f\u7269\u3002STAT3\u867d\u7136\u591a\u5e74\u6765\u88ab\u8ba4\u4e3a\u662f\u6cbb\u7597\u80bf\u7624\u7684\u91cd\u8981\u9776\u70b9\uff0c\u4f46\u662f\u5927\u591a\u6570\u52aa\u529b\u90fd\u805a\u7126\u4e8e\u9776\u5411\u4e0a\u6e38\u4fe1\u53f7\u901a\u8def\u3002<\/strong>WP1066\u5177\u6709\u5728\u4f53\u5916\u548c\u52a8\u7269\u6a21\u578b\u4e2d\u76f4\u63a5\u6291\u5236STAT3\u6d3b\u6027\u7684\u72ec\u7279\u80fd\u529b\uff0c<\/strong>\u5b83\u80fd\u591f\u4ea7\u751f\u663e\u8457\u7684\u6297\u764c\u6548\u679c\uff0c\u5305\u62ec\u6291\u5236\u80bf\u7624\u751f\u957f\u548c\u63d0\u9ad8\u52a8\u7269\u751f\u5b58\u671f\u3002<\/span><\/p>\n


<\/p>\n

3.\t<\/span>\u6cbb\u7597\u80c6\u7ba1\u764c\uff0cSK2\u6291\u5236\u52422a\u671f\u8bd5\u9a8c\u53d6\u5f97\u79ef\u6781\u8fdb\u5c55<\/span><\/strong><\/span><\/p>\n


<\/p>\n

9\u67086\u65e5\uff0c RedHill Biopharma\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u6d88\u5316\u9053\u75be\u75c5\u836f\u7269\u7814\u53d1\u7684\u751f\u7269\u533b\u836f\u516c\u53f8\u5ba3\u5e03\uff0c\u53e3\u670dYELIVA\u00ae\uff08opaganib\uff0cABC294640\uff09\u6cbb\u7597\u665a\u671f\u80c6\u7ba1\u764c\u7684\u5355\u81c22a\u671f\u7814\u7a76\u5df2\u7ecf\u8fbe\u5230\u4e86\u9884\u5148\u8bbe\u5b9a\u7684\u7597\u6548\u76ee\u6807\u3002\u56e0\u6b64\uff0c\u8be5\u7814\u7a76\u5c06\u8fdb\u5165\u7b2c\u4e8c\u9636\u6bb5\uff0c\u62db\u52df39\u540d\u53ef\u8bc4\u4f30\u60a3\u8005\u7684\u5b8c\u6574\u961f\u5217\u3002\u60a3\u8005\u5165\u7ec4\u9884\u8ba1\u5c06\u4e8e2019\u5e74\u5e74\u4e2d\u5b8c\u6210\u3002YELIVA\u00ae\u662f\u4e00\u79cd\u5904\u4e8e2\u671f\u8bd5\u9a8c\u9636\u6bb5\u7684\u65b0\u5316\u5b66\u5b9e\u4f53\uff0c\u5c5e\u4e8e\u53e3\u670d\u7ed9\u836f\u7684\u201cfirst-in-class\u201d\u9798\u6c28\u9187\u6fc0\u9176-2\uff08SK2\uff09\u9009\u62e9\u6027\u6291\u5236\u5242<\/strong>\uff0c\u5177\u6709\u6297\u764c\u548c\u6297\u708e\u6d3b\u6027\uff0c\u53ef\u9488\u5bf9\u80bf\u7624\u5b66\uff0c\u708e\u75c7\u548c\u80c3\u80a0\u9053\u9002\u5e94\u75c7\u3002YELIVA\u00ae\u66fe\u83b7\u5f97FDA \u6388\u4e88\u6cbb\u7597\u80c6\u7ba1\u764c\u7684\u5b64\u513f\u836f\u8d44\u683c\u3002<\/span><\/p>\n


<\/p>\n

4.\t<\/span>Five Prime\u4e0e\u518d\u9f0e\u5408\u4f5c\u5f00\u53d1\uff0c\u80c3\u764cFGFR2b\u9776\u5411\u7597\u6cd5\u542f\u52a8\u5168\u74033\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/strong><\/span><\/p>\n


<\/p>\n

9\u670810\u65e5\uff0c\u81f4\u529b\u4e8e\u7814\u53d1\u521b\u65b0\u80bf\u7624\u514d\u75ab\u86cb\u767d\u7597\u6cd5\u7684\u751f\u7269\u6280\u672f\u516c\u53f8Five Prime Therapeutics\u5ba3\u5e03\u5b8c\u6210\u4e86\u9488\u5bf9bemarituzumab\uff08FPA144\uff09\uff0c\u540d\u4e3aFIGHT\u76841\/3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u76841\u671f\u5b89\u5168\u6027\u8bc4\u4f30\u90e8\u5206\uff0c\u5e76\u4e14\u5df2\u7ecf\u542f\u52a83\u671f\u7814\u7a76\u3002Bemarituzumab\u662f\u4e00\u79cd\u7279\u5f02\u6027FGF\u53d7\u4f532b\uff08FGFR2b\uff09\u6297\u4f53\uff0c\u5b83\u4f5c\u4e3a\u8fc7\u8868\u8fbeFGFR2b\u7684\u80bf\u7624\u9776\u5411\u514d\u75ab\u7597\u6cd5\uff0c\u53ef\u4e0e\u5316\u7597\u8054\u5408\u7528\u4e8e\u5148\u524d\u672a\u7ecf\u6cbb\u7597\u7684\u665a\u671f\u80c3\u764c\uff08GC\uff09\u6216\u80c3\u98df\u7ba1\u8fde\u63a5\uff08GEJ\uff09\u764c\u75c7\u60a3\u8005\u3002<\/strong>2017\u5e7412\u6708\uff0cFive Prime\u548c\u518d\u9f0e\uff08Zai Lab\uff09\u5ba3\u5e03\u8fbe\u6210\u4e86bemarituzumab\u5728\u5927\u4e2d\u534e\u533a\u7684\u5f00\u53d1\u548c\u63a8\u5e7f\u6218\u7565\u5408\u4f5c\u3002<\/span><\/p>\n


<\/p>\n

5.\t<\/span>Exelixis\u516c\u53f8TKI\u836f\u7269\u83b7\u5f97NCCN\u6307\u5357\u63a8\u8350\uff0c\u7528\u4e8e\u665a\u671f\u80be\u764c<\/span><\/strong><\/span><\/p>\n


<\/p>\n

9\u670810\u65e5\uff0cExelixis\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fd\u56fd\u5bb6\u7efc\u5408\u764c\u75c7\u7f51\u7edc\uff08NCCN\uff09\u66f4\u65b0\u4e86\u5173\u4e8eCabometyx\uff08cabozantinib\uff09\u7247\u5242\u7684\u4e34\u5e8a\u5b9e\u8df5\u6307\u5357\u5efa\u8bae\uff0c\u63a8\u8350\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\uff0c\u65e0\u8bba\u60a3\u8005\u7684\u98ce\u9669\u72b6\u6001\u5982\u4f55\uff08\u4f4e\u5371\u3001\u4e2d\u5371\u3001\u9ad8\u5371\uff09<\/strong>\u3002\u6839\u636eNCCN\u63a8\u8350\uff0cCabometyx<\/span>\u662f\u4e2d\u5371\u548c\u9ad8\u5371\u4eba\u7fa4\u4e2d\u4e00\u7ebf\u60a3\u8005\u552f\u4e00\u9996\u9009\u7684\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\uff0c\u4ee5\u53ca\u5148\u524d\u7ecf\u8fc7\u6cbb\u7597\u7684\u60a3\u8005\u552f\u4e00\u9996\u9009\u7684TKI\u6cbb\u7597\u65b9\u6848\u3002\u6b64\u5916\uff0c\u5728\u6700\u8fd1\u5bf9\u809d\u80c6\u764c\u4e34\u5e8a\u5b9e\u8df5\u6307\u5357\u7684\u66f4\u65b0\u4e2d\uff0cNCCN\u5c06Cabometyx<\/span><\/span>\u4f5c\u4e3a\u6cbb\u7597\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u60a3\u8005\u76841\u7c7b\u9009\u62e9\uff0c\u8fd9\u4e9b\u60a3\u8005\u4e4b\u524d\u66fe\u63a5\u53d7\u8fc7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u3002Cabometyx<\/span>\u5c1a\u672a\u83b7\u5f97FDA\u6279\u51c6\u7528\u4e8e\u5148\u524d\u7ecf\u6cbb\u7684\u665a\u671fHCC\u60a3\u8005\u30022018\u5e745\u670829\u65e5\uff0c\u7f8e\u56fdFDA\u63a5\u53d7\u4e86Cabometyx<\/span>\u9488\u5bf9\u5148\u524d\u7ecf\u6cbb\u7684\u665a\u671fHCC\u7684\u8865\u5145\u65b0\u836f\u7533\u8bf7\uff0cPDUFA\u65e5\u671f\u662f2019\u5e741\u670814\u65e5\u3002<\/span><\/p>\n


<\/p>\n

\u80bf\u7624\u9776\u5411\u7597\u6cd5\u7cfb\u5217\uff1a<\/span><\/strong><\/p>\n

\u7b2c7\u671f<\/span><\/strong><\/span><\/a> |<\/span> \u7b2c6\u671f<\/span><\/strong><\/span><\/a> | <\/span>\u7b2c5\u671f<\/span><\/strong><\/a><\/span><\/strong> | <\/span>\u7b2c4\u671f<\/span><\/strong><\/a> | <\/span>\u7b2c3\u671f<\/span><\/strong><\/a> | <\/span>\u7b2c2\u671f<\/span><\/strong><\/a> <\/span><\/strong>| <\/span>\u7b2c1\u671f<\/a><\/strong><\/p>\n


<\/span><\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] \t<\/span>\u536b\u6750\u548c\u9ed8\u6c99\u4e1c\u5ba3\u5e03\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u4e50\u536b\u739b\u00ae\uff08\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c. Retrieved Sep 5, 2018, from \u5fae\u4fe1\u53f7\uff08EisaiChinaComm\uff09<\/span><\/p>\n

[2] \t<\/span>Moleculin\u2019s Brain Cancer Drug Candidate Begins Patient Dosing at Clinical Trial Being Conducted at MD Anderson. Retrieved September 13, 2018, from https:\/\/ir.moleculin.com\/press-releases\/detail\/98\/moleculins-brain-cancer-drug-candidate-begins-patient<\/span><\/p>\n

[3] \t<\/span>RedHill Biopharma Announces Advancement to Second Stage of Phase IIa Study with YELIVA\u00ae for Cholangiocarcinoma. Retrieved September 10, 2018, from https:\/\/www.biospace.com\/article\/redhill-biopharma-announces-advancement-to-second-stage-of-phase-iia-study-with-yeliva-for-cholangiocarcinoma\/?s=95<\/span><\/p>\n

[4] \t<\/span>Five Prime Therapeutics Completes Phase 1 Safety Lead-In and Initiates Phase 3, Global Registrational Trial of Bemarituzumab in Front-Line Advanced Gastric and Gastroesophageal Junction Cancers. Retrieved September 10, 2018, from https:\/\/www.businesswire.com\/news\/home\/20180910005202\/en\/Prime-Therapeutics-Completes-Phase-1-Safety-Lead-In<\/span><\/p>\n

[5] \t<\/span>Exelixis Announces New Recommendations for CABOMETYX\u00ae (Cabozantinib) Tablets in Updated National Comprehensive Cancer Network Clinical Practice Guidelines.  Retrieved September 7, 2018, from https:\/\/www.businesswire.com\/news\/home\/20180907005050\/en\/Exelixis-Announces-New-Recommendations-CABOMETYX%C2%AE-Cabozantinib-Tablets<\/span><\/p>\n


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