{"id":49195,"date":"2018-09-24T01:00:00","date_gmt":"2018-09-26T01:56:13","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e8%b7%9f%e9%9a%8f%e7%a0%94%e5%8f%91%e5%ae%9e%e4%be%8b%e5%ad%a6%e4%b9%a0%e7%bb%93%e6%9e%84%e4%bc%98%e5%8c%96\/"},"modified":"2018-09-26T09:56:18","modified_gmt":"2018-09-26T01:56:18","slug":"%e8%b7%9f%e9%9a%8f%e7%a0%94%e5%8f%91%e5%ae%9e%e4%be%8b%e5%ad%a6%e4%b9%a0%e7%bb%93%e6%9e%84%e4%bc%98%e5%8c%96","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/49195\/","title":{"rendered":"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"text-align: center;\"><img class=\"\"      style=\"vertical-align: middle;width: 80%;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537926974.gif\" alt=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\" title=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\"  \/><\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p><br  \/><\/p>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u7ed3\u6784\u4f18\u5316\u53ef\u4ee5\u8bf4\u662f\u836f\u7269\u5316\u5b66\u7814\u7a76\u4e2d\u7684\u4e00\u9879\u91cd\u5934\u620f\u3002\u65e0\u8bba\u662f\u6784\u6548\u5173\u7cfb\u603b\u7ed3\uff0c\u8fd8\u662f\u5206\u5b50\u6a21\u62df\u8ba1\u7b97\uff0c\u5927\u5bb6\u7684\u76ee\u7684\u5f88\u660e\u786e\u90fd\u662f\u60f3\u901a\u8fc7\u4e0d\u65ad\u7684\u7ed3\u6784\u4f18\u5316\u5f97\u5230\u80fd\u8d70\u4e0a\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5019\u9009\u836f\u7269\u5206\u5b50\uff0c\u6700\u7ec8\u624d\u53ef\u80fd\u83b7\u5f97\u65f7\u4e16\u96be\u5bfb\u7684\u521b\u65b0\u836f\u7269\u3002\u4e0e\u4f17\u591a\u9ad8\u6821\u7814\u7a76\u673a\u6784\u4e0d\u540c\uff0c\u5236\u836f\u4f01\u4e1a\u5bf9\u521b\u65b0\u836f\u7269\u7684\u7814\u53d1\u5177\u6709\u6781\u5927\u7684\u6e34\u671b\uff0c\u6bd5\u7adf\u8fd9\u5173\u4e4e\u4f01\u4e1a\u80a1\u4ef7\u5e02\u503c\u4e43\u81f3\u751f\u6b7b\u5b58\u4ea1\u3002\u6b63\u56e0\u5982\u6b64\uff0c\u5168\u7403\u9876\u5c16\u5236\u836f\u4f01\u4e1a\u7684\u7814\u53d1\u6548\u7387\u4e5f\u662f\u60ca\u4eba\u7684\uff0c\u5176\u9879\u76ee\u4fe1\u606f\u4e0e\u8fdb\u5ea6\u66f4\u662f\u5907\u53d7\u5173\u6ce8\u3002\u4eca\u5929\u7b14\u8005\u8981\u4e3a\u5927\u5bb6\u5206\u4eab\u7684\u7ed3\u6784\u4f18\u5316\u6848\u4f8b\u5c31\u6765\u81ea\u8f89\u745e\u5236\u836f\u7684\u7814\u53d1\u9879\u76ee<\/span><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>PF-06409577<\/strong><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002\u4fe1\u606f\u5168\u90e8\u662f\u7b14\u8005\u4ece\u516c\u5f00\u6765\u6e90\u603b\u7ed3\u51fa\u6765\u7684\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">\u5316\u5408\u7269PF-06409577\u662f\u8f89\u745e\u5236\u836f\u5f00\u53d1\u7684\u4e00\u79cdAMPK-\u03b21\u9009\u62e9\u6027\u6fc0\u52a8\u5242<\/span><\/strong><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\uff0c\u516c\u5f00\u4fe1\u606f\u663e\u793a\u8f89\u745e\u5c06\u8be5\u5316\u5408\u7269\u7528\u4e8e\u7cd6\u5c3f\u75c5\u80be\u75c5\u9886\u57df\u836f\u7269\u7814\u53d1\u3002<\/span><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>AMPK\u5168\u79f05\u2032-Adenosine Monophosphate-Activated Protein Kinase\uff0c\u7b97\u5f97\u4e0a\u662f\u4e00\u4e2a\u201c\u795e\u5947\u201d\u7684\u9776\u70b9\u3002<\/strong><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u7cd6\u5c3f\u75c5\uff0c\u764c\u75c7\uff0c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u968f\u5904\u53ef\u89c1\u5173\u4e8e\u8fd9\u4e2a\u9776\u70b9\u7684\u76f8\u5173\u7814\u7a76\u3002\u201c\u795e\u836f\u201d\u4e8c\u7532\u53cc\u80cd\u7684\u8bf8\u591a\u836f\u7406\u673a\u5236\u66f4\u662f\u548cAMPK\u6709\u7740\u5343\u4e1d\u4e07\u7f15\u7684\u8054\u7cfb\u3002\u8f89\u745e\u5236\u836f\u81ea\u7136\u4e5f\u4e0d\u4f1a\u653e\u8fc7\u8fd9\u4e2a\u201c\u77e5\u540d\u201d\u9776\u70b9\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537926974.jpg\" alt=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\" title=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;\">AMPK\u6676\u4f53\u7ed3\u6784\uff08PDBID:5KQ5\uff09<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section  label=\"Powered by 135editor.com\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"padding-top: 10px;padding-bottom: 10px;box-sizing: border-box;\">\n<section style=\"width: 100%;border-top: 1px solid rgb(170, 170, 171);border-bottom: 1px solid rgb(170, 170, 171);box-sizing: border-box;\" >\n<section style=\"width: 45px;padding-right: 5px;padding-left: 5px;margin-top: -14px;box-sizing: border-box;\"><img class=\"\"      style=\"width: 100%;margin-left: -5px;background: none rgb(156, 218, 245);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537926975.png\" alt=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\" title=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\"  \/><\/section>\n<section style=\"font-size: 15px;color: rgb(63, 62, 63);text-align: justify;line-height: 25px;box-sizing: border-box;\" class=\"135brush\">\n<p style=\"font-family: Helvetica, Arial, sans-serif;font-size: medium;line-height: 1.75em;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">2016\u5e748\u6708<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\uff0c\u8f89\u745e\u7684\u7814\u7a76\u4eba\u5458\u5148\u662f\u5728J.Med.Chem.\u6742\u5fd7\u4e0a\u62a5\u9053\u4e86\u4e00\u79cd\u4ed6\u4eec\u5f00\u53d1\u7684AMPK\u6fc0\u52a8\u5242\u7b5b\u9009\u65b9\u6cd5\uff0c\u5e76\u4ee5\u6b64\u7b5b\u9009\u65b9\u6cd5\u53d1\u73b0\u4e86\u82d7\u5934\u5316\u5408\u72691\uff0c\u7ecf\u8fc7\u7ed3\u6784\u4f18\u5316\u5f97\u5230\u4e86PF-06409577\uff0c\u5e76\u7b80\u5355\u62a5\u9053\u4e86\u5176\u5bf9\u7cd6\u5c3f\u75c5\u80be\u75c5\u52a8\u7269\u7684\u836f\u7406\u4f5c\u7528<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[1]<\/span><\/sup>\u3002\u7ed3\u6784\u4f18\u5316\u91cd\u70b9\u662f\u4ece\u82d7\u5934\u5316\u5408\u7269\u51fa\u53d1\uff0c\u786e\u5b9a\u6d3b\u6027\u7ed3\u6784\u6bcd\u6838\u517c\u987e\u6eb6\u89e3\u6027\uff0c\u6e17\u900f\u6027\uff0c\u6e05\u9664\u7387\u7b49\u6210\u836f\u6027\u3002<\/span><\/p>\n<p style=\"font-family: Helvetica, Arial, sans-serif;font-size: medium;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"font-family: Helvetica, Arial, sans-serif;font-size: medium;line-height: 1.75em;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">2017\u5e745\u6708<\/span><\/strong><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\uff0c\u4ed6\u4eec\u5728J. Pharmacol. Exp. Ther.\u6742\u5fd7\u4e0a\u8be6\u7ec6\u62a5\u9053\u4e86\u5176\u901a\u8fc7\u6fc0\u52a8AMPK\u5b9e\u73b0\u5bf9\u7cd6\u5c3f\u75c5\u80be\u75c5\u5927\u9f20\u80be\u529f\u80fd\u7684\u6539\u5584\u4f5c\u7528<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[2]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"font-family: Helvetica, Arial, sans-serif;font-size: medium;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"font-family: Helvetica, Arial, sans-serif;font-size: medium;line-height: 1.75em;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">2018\u5e742\u6708<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\uff0c\u4ed6\u4eec\u5728J.Med.Chem.\u6742\u5fd7\u4e0a\u518d\u5ea6\u53d1\u6587\uff0c\u62a5\u9053\u4e86PF-06409577\u7ed3\u6784\u4f18\u5316\u540e\u7684\u4e24\u4e2a\u5206\u5b50PF-06679142\u548cPF-06685249\u3002\u5728\u8fd9\u7bc7\u6587\u7ae0\u4e2d\u4ed6\u4eec\u8981\u89e3\u51b3\u7684\u95ee\u9898\u662f\u5e0c\u671b\u964d\u4f4ePF-06409577\u7684\u8840\u6d46\u6e05\u9664\u7387\u548c\u80be\u810f\u6e05\u9664\u7387\u3002\u8fd9\u8f6e\u7ed3\u6784\u4f18\u5316\u7684\u7b56\u7565\u5f88\u660e\u786e\uff0c\u901a\u8fc7\u964d\u4f4ePF-06409577\u7684logD\u5b9e\u73b0\u964d\u4f4e\u5316\u5408\u7269\u4e3b\u52a8\u6392\u6cc4\uff0c\u63d0\u9ad8\u88ab\u52a8\u6e17\u900f\u7387\uff08Passive permeability\uff0cPapp\uff09\u8fbe\u5230\u589e\u52a0\u88ab\u52a8\u91cd\u5438\u6536\u964d\u4f4e\u6e05\u9664\u7387\u7684\u6548\u679c<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[3]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"font-family: Helvetica, Arial, sans-serif;font-size: medium;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"font-family: Helvetica, Arial, sans-serif;font-size: medium;line-height: 1.75em;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">2018\u5e745\u6708<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\uff0c\u4ed6\u4eec\u5728EBioMedicine\u6742\u5fd7\u4e0a\u53d1\u8868\u6587\u7ae0\u62a5\u9053\u4e86PF-06409577\u6539\u5584\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u7684\u836f\u7406\u4f5c\u7528<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[4]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"font-family: Helvetica, Arial, sans-serif;font-size: medium;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"font-family: Helvetica, Arial, sans-serif;font-size: medium;line-height: 1.75em;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">2018\u5e748\u6708<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\uff0c\u4ed6\u4eec\u5728J.Med.Chem.\u6742\u5fd7\u4e0a\u518d\u5ea6\u53d1\u6587\uff0c\u8981\u89e3\u51b3\u7684\u4f9d\u7136\u662f\u5316\u5408\u7269\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u3002\u8fd9\u6b21\u4ed6\u4eec\u53d1\u73b0PF-06409577\u7684\u8461\u8404\u7cd6\u919b\u9178\u82f7\u5316\u4f5c\u7528\u662f\u5176\u91cd\u8981\u7684\u4ee3\u8c22\u9014\u5f84\uff0c\u5e76\u4e14\u9274\u5b9a\u3001\u5236\u5907\u51faPF-06409577\uff0cPF-06679142\u548cPF-06685249\u7684\u8461\u8404\u7cd6\u919b\u9178\u82f7\u5316\u4ee3\u8c22\u4ea7\u7269M1-M3\u3002\u7ecf\u8fc7\u6d4b\u8bd5\uff0c\u4ee3\u8c22\u4ea7\u7269M1-M3\u4f9d\u7136\u5177\u6709AMPK\u6fc0\u52a8\u4f5c\u7528\uff0c\u5176\u548cAMPK\u7684\u7ed3\u5408\u89e3\u79bb\u5f3a\u5ea6\u6bd4\u539f\u578b\u5316\u5408\u7269\u4ec5\u964d\u4f4e\u4e86\u4e00\u4e2a\u6570\u91cf\u7ea7\u3002\u66f4\u6709\u610f\u601d\u7684\u662f\uff0cPF-06409577\u7684\u8461\u8404\u7cd6\u919b\u9178\u82f7\u5316\u4ee3\u8c22\u7269M1\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u5168\u9762\u8d85\u8d8a\u539f\u578b\u5316\u5408\u7269\uff0c\u5728\u5927\u9f20\u4e2d\u7684AUC\u63d0\u9ad8\u4e8610\u4f59\u500d\uff0ct1\/2\u63d0\u9ad8\u4e86\u8fd17\u500d<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[5]<\/span><\/sup>\u3002\u8fd9\u4e2a\u6848\u4f8b\u544a\u8bc9\u6211\u4eec\uff0c\u6d3b\u6027\u4ee3\u8c22\u4ea7\u7269\u7684\u836f\u4ee3\u6027\u8d28\u66f4\u4e3a\u5408\u7406\uff0c\u5728\u6d3b\u6027\u635f\u5931\u4e0d\u5927\u7684\u65f6\u5019\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u65b0\u7684\u5148\u5bfc\u5316\u5408\u7269\u8fdb\u884c\u6df1\u5165\u5f00\u53d1\u3002<\/span><\/p>\n<\/section>\n<section style=\"display: flex;justify-content: flex-end;\">\n<section style=\"width: 45px;padding-right: 5px;padding-left: 5px;margin-bottom: -11px;box-sizing: border-box;\"><img class=\"\"      style=\"width: 100%;background: none rgb(156, 218, 245);margin-left: 5px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537926975.png\" alt=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\" title=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section  label=\"Powered by 135editor.com\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section style=\"width: 100%;padding-top: 20px;padding-bottom: 20px;box-sizing: border-box;\" >\n<section style=\"width: 100%;\" >\n<section style=\"font-size: 15px;padding-top: 10px;padding-bottom: 10px;text-align: justify;line-height: 25px;letter-spacing: 1px;color: rgb(0, 128, 255);box-sizing: border-box;\" class=\"135brush\">\n<p><span style=\"font-family: Helvetica, Arial, sans-serif;color: rgb(0, 0, 0);\">\u5149\u770b\u6587\u5b57\u4e0d\u591f\u76f4\u89c2\uff0c\u7b14\u8005\u6574\u7406\u4e86\u4e00\u5f20\u56fe\u5927\u81f4\u6982\u51b5\u4e86PF-06409577\u8fd9\u4e2aAMPK\u6fc0\u52a8\u5242\u9879\u76ee\u7684\u7814\u53d1\u59cb\u672b\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<section>\n<section style=\"width: 100%;height: 6px;background: rgb(0, 128, 255);margin-bottom: -18px;overflow: hidden;box-shadow: rgb(153, 153, 153) -1px 1px 5px 0px;color: rgb(255, 255, 255);\" ><\/section>\n<section style=\"width: 25px;height: 25px;border-radius: 100%;background: rgb(255, 255, 255);margin-right: auto;margin-left: auto;border-width: 5px;border-style: solid;border-color: rgb(0, 128, 255);overflow: hidden;box-sizing: border-box;\"><\/section>\n<section style=\"width: 100%;height: 10px;background: rgb(255, 255, 255);margin-top: -32px;padding-bottom: 20px;box-sizing: border-box;\" ><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img class=\"\"           style=\"width: 558px;height: 713px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537926975.jpeg\" alt=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\" title=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u7ec6\u5fc3\u7684\u8bfb\u8005\u4e0d\u96be\u53d1\u73b0\uff0cPF-06409577\u9996\u6b21\u516c\u5f00\u53d1\u8868\u662f\u57282016\u5e74\uff0c\u4f46\u662f\u9996\u6b21\u767b\u8bb0\u4e34\u5e8a\u8bd5\u9a8c\u5374\u662f\u57282014\u5e74\uff08NCT02286882\uff0c\u8be5\u8bd5\u9a8c\u4e8e2015\u5e74\u7ec8\u6b62\uff09<\/span><span style=\"font-size: 15px;\"><sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[6]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002\u8fd9\u4e5f\u9a8c\u8bc1\u4e86\u574a\u95f4\u7684\u4e00\u8d2f\u4f20\u95fb\uff0c\u201c\u597d\u591a\u836f\u5382\u90fd\u662f\u628a\u6ca1\u5e0c\u671b\u7684\u9879\u76ee\u62ff\u6765\u53d1\u6587\u7ae0\u201d\u3002\u54b1\u4eec\u59d1\u4e14\u4e0d\u53bb\u731c\u6d4b\u8fd9\u4e2a\u7cfb\u5217\u5316\u5408\u7269\u6700\u7ec8\u80fd\u4e0d\u80fd\u6210\u4e3a\u4e0a\u5e02\u836f\u7269\u3002\u7b14\u8005\u8ba4\u4e3a\u8be5\u9879\u76ee\u7684\u6574\u4e2a\u5f00\u53d1\u601d\u8def\u5bf9\u5404\u4f4d\u4ece\u4e8b\u65b0\u836f\u7814\u53d1\u7684\u836f\u7269\u5316\u5b66\u5de5\u4f5c\u8005\u6765\u8bf4\u8fd8\u662f\u5f88\u6709\u5b66\u4e60\u501f\u9274\u610f\u4e49\u3002\u7b14\u8005\u6574\u7406\u8fd9\u4e9b\u4fe1\u606f\u613f\u4e0e\u8bf8\u541b\u5171\u5b66\u5171\u52c9\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[1].J. Med. Chem. 2016, 59, 8068<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[2].J. Pharmacol. Exp. Ther. 2017, 361(2):303-311<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[3].J. Med. Chem., 2018, 61 (6), 2372\u20132383<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[4].EBioMedicine. 2018, 31:122-132<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[5].J. Med. Chem., 2018, 61 (16), 7273\u20137288<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[6].Clinical Trials, NCT02286882, 2014-2015<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"color: rgb(74, 82, 165);padding-top: 2em;padding-bottom: 2em;box-sizing: border-box;\">\n<section style=\"text-align: center;\">\n<section class=\"135brush\"  style=\"font-size:18px;\">END<\/section>\n<section style=\"width: 60px;margin-right: auto;margin-left: auto;display: inline-block;\"><img class=\"\"      style=\"width: 100%;display: block;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537926975.png\" alt=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\" title=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section>\n<section style=\"text-align: center;\">\n<section style=\"width:240px;display:inline-block;\">\n<section   style=\"border-radius: 100%;overflow: hidden;box-shadow: rgb(207, 207, 206) 2px 2px 5px;margin-right: auto;margin-left: auto;width: 100%;padding-bottom: 100%;height: 0px;background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537926978.jpeg');background-position: 50% 50%;background-size: cover;box-sizing: border-box;\"><img class=\"\"     style=\"opacity:0;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537926975.jpeg\" alt=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\" title=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\"  \/><\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: -75px;\">\n<section style=\"width:140px;display:inline-block;\"><img class=\"\"      style=\"width: 100%;display: block;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537926976.png\" alt=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\" title=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section  label=\"Powered by 135editor.com\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"text-align: center;\"><img class=\"\"      style=\"width: 80%;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537926976.gif\" alt=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\" title=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\"  \/><\/section>\n<\/section>\n<p style=\"text-align: center;line-height: 1.5em;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MjEzODQ3NA==&amp;mid=2655762730&amp;idx=1&amp;sn=1e7cd8a6771f1081181c7f9f5bd48b8a&amp;chksm=8bcea7afbcb92eb9e0cd65a89eb9e9452d175f0e767ae0ffb2e055ba496f8976e353371cf6e3&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;font-size: 14px;\"><span style=\"font-size: 14px;\">2018\u5e747\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5<\/span><\/a><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MjEzODQ3NA==&amp;mid=2655762667&amp;idx=1&amp;sn=2192250bb8102fcbd33f49acea822b43&amp;chksm=8bcea66ebcb92f78dcd954d946228dd4b6aa2594236e8a0678994279838439636d3af11258ef&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;font-size: 14px;\"><span style=\"font-size: 14px;\">2018\u5e748\u6708\u4e2d\u56fd1\u7c7b\u65b0\u836f\u4e34\u5e8a\u52a8\u6001<\/span><\/a><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MjEzODQ3NA==&amp;mid=2655762432&amp;idx=1&amp;sn=14115ccf779c99a4c0bd579b26d054f6&amp;chksm=8bcea685bcb92f93d08b521f46e2c35da8ce6bff36d675bdcadfd81fa67f11c9010387df633f&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;font-size: 14px;\"><span style=\"font-size: 14px;\">\u55b9\u5549\u5728\u6297\u764c\u836f\u7269\u4e2d\u7684\u5e94\u7528<\/span><\/a><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MjEzODQ3NA==&amp;mid=2655762746&amp;idx=1&amp;sn=2e66dd28eaa12ae071263cf0c23f8167&amp;chksm=8bcea7bfbcb92ea9b7452b83adedf4e4230c393b312799c0a92ab4e7b9705ff600667d048138&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;font-size: 14px;\"><span style=\"font-size: 14px;\">\u60f3\u968f\u65f6\u4e86\u89e3\u5168\u7403\u4e0a\u5e02\u65b0\u836f\uff1f\u4e0a\u836f\u6e21\u65b0\u7248App\u627e\u201c\u65b0\u836f\u201d\uff01<\/span><\/a><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MjEzODQ3NA==&amp;mid=2655762730&amp;idx=2&amp;sn=e6300a27c523dbabffb745e71b955f75&amp;chksm=8bcea7afbcb92eb9cfbc718d33ab0f6d7fabe4960e2e5b1f7b73fc44f3dbabec7f6d7fcfc6e5&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;font-size: 14px;\"><span style=\"font-size: 14px;\">\u836f\u6e21APP\u5168\u9762\u5347\u7ea7\u5566\uff01\u4e00\u89c8\u5168\u7403\u83b7\u6279\u65b0\u836f\uff0c\u4e2d\u56fd\u4e34\u5e8a\u9879\u76ee\uff0c\u884c\u4e1a\u878d\u8d44\u4fe1\u606f\uff0c\u5b9e\u65f6\u66f4\u65b0\uff0c\u5168\u8986\u76d6\uff01<\/span><\/a><br  \/><\/p>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MjEzODQ3NA==&amp;mid=2655762488&amp;idx=2&amp;sn=8f278096debef35b578d6e03e56e3488&amp;chksm=8bcea6bdbcb92fabd503d5bb73cc273697ebf0769fbb7bfb96056b5dce3644647bd18e9d2fbe&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-align: center;white-space: normal;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;right: auto;bottom: auto;\"><img class=\"\"               style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537926976.jpg\" alt=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\" title=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\"  \/><\/span><\/a><\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA5MjEzODQ3NA==&amp;mid=2655756292&amp;idx=6&amp;sn=8ae873807e0f13e4eaaea32a11123559&amp;chksm=8bcebe81bcb9379718fa3f7c97699a16524969f4b74d9a3e1b46329a304786628bc806562b51&amp;scene=21#wechat_redirect\" target=\"_blank\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;margin: 0px;right: auto;bottom: auto;\"><img class=\"\"               style=\"margin: 0px;width: 100%;height: auto;top: auto;left: auto;right: auto;bottom: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537926977.jpeg\" alt=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\" title=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\"  \/><\/span><\/a><\/p>\n<p style=\"text-align: center;\"><img class=\"\"           style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537926977.jpeg\" alt=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\" title=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"           style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537926977.jpeg\" alt=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\" title=\"\u8ddf\u968f\u7814\u53d1\u5b9e\u4f8b\u5b66\u4e60\u7ed3\u6784\u4f18\u5316\"  \/><\/p>\n<section class=\"RankEditor\" style=\"margin-top: 20px;\">\n<section style=\"display: inline-block;vertical-align: middle;width:12%;box-sizing: border-box;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"display:inline-block;width: 88%;padding:5px;box-sizing: border-box;vertical-align:middle;\">\n<p class=\"active brush\" style=\"box-sizing: border-box;font-size: 16px;color: rgb(121,121,121);min-width:1px;\"><span style=\"font-size: 15px;\">\u7acb\u5373\u89e3\u9501\u4f60\u7684\u638c\u4e0a\u4e13\u4e1a\u5de5\u5177\uff01<\/span><\/p>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7ed3\u6784\u4f18\u5316\u53ef\u4ee5\u8bf4\u662f\u836f\u7269\u5316\u5b66\u7814\u7a76\u4e2d\u7684\u4e00\u9879\u91cd\u5934\u620f\u3002\u65e0\u8bba\u662f\u6784\u6548\u5173\u7cfb\u603b\u7ed3\uff0c\u8fd8\u662f\u5206\u5b50\u6a21\u62df\u8ba1\u7b97\uff0c\u5927\u5bb6\u7684\u76ee\u7684\u5f88\u660e\u786e\u90fd\u662f\u60f3\u901a\u8fc7\u4e0d 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