{"id":49310,"date":"2018-09-20T01:00:00","date_gmt":"2018-09-26T01:57:17","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/pi3k%e6%8a%91%e5%88%b6%e5%89%82-%e7%99%8c%e7%97%87%e6%b2%bb%e7%96%97%e7%9a%84%e6%96%b0%e9%80%89%e6%8b%a9\/"},"modified":"2018-09-26T09:57:20","modified_gmt":"2018-09-26T01:57:20","slug":"pi3k%e6%8a%91%e5%88%b6%e5%89%82-%e7%99%8c%e7%97%87%e6%b2%bb%e7%96%97%e7%9a%84%e6%96%b0%e9%80%89%e6%8b%a9","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/49310\/","title":{"rendered":"PI3K\u6291\u5236\u5242\u2014\u2014\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u9009\u62e9"},"content":{"rendered":"
\n

\"PI3K\u6291\u5236\u5242\u2014\u2014\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u9009\u62e9\"<\/p>\n


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\u5728\u4eba\u7c7b\u80bf\u7624\u7ec6\u80de\u4e2d\uff0cPI3K\u2013AKT\u2013mTOR\u4fe1\u53f7\u901a\u8def\u662f\u6700\u5e38\u89c1\u7684\u5931\u8c03\u901a\u8def\u3002\u4f46\u8fd9\u6761\u901a\u8def\u53c8\u662f\u5982\u6b64\u91cd\u8981\uff0c\u6d89\u53ca\u5230\u6b63\u5e38\u7ec6\u80de\u7684\u4ee3\u8c22\u3001\u751f\u957f\u4e0e\u7e41\u6b96\uff0c\u800c\u80bf\u7624\u7ec6\u80de\u4e5f\u9760\u7740\u8fd9\u6761\u901a\u8def\u7ef4\u6301\u7740\u751f\u957f\u3001\u8f6c\u79fb\u4e0e\u6269\u6563\u3002\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\uff0c\u8fd9\u6761\u901a\u8def\u88ab\u5f02\u5e38\u6fc0\u6d3b\uff0c\u5305\u62ecPIK3CA\u3001PIK3R1\u3001PTEN\u3001AKT\u3001TSC1\u3001TSC2\u3001LKB1 \u3001MTOR\u7b49\u591a\u79cd\u6291\u764c\u57fa\u56e0\u7ec4\u53d1\u751f\u6539\u53d8\u3002
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\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0c<\/span>\u9776\u5411PI3K\u2013AKT\u2013mTOR\u901a\u8def\u7684\u6291\u5236\u5242\u5bf9\u6cbb\u7597\u80bf\u7624\u6709\u79ef\u6781\u4f5c\u7528\uff0c\u5305\u62ecPI3K \u4e0eAKT\u6291\u5236\u5242\u3001\u5f02\u6784mTOR\u6291\u5236\u5242\u4e0e\u50ac\u5316mTOR\u6291\u5236\u5242\u90fd\u6709\u663e\u8457\u7684\u6297\u80bf\u7624\u6548\u679c<\/strong><\/span>\u3002\u76ee\u524d\u5df2\u670940\u591a\u79cd\u5316\u5408\u7269\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f46\u53ea\u6709<\/span>\u4e24\u4e2amTOR\u6291\u5236\u5242temsirolimus \u4e0eeverolimus\u3001\u4e24\u4e2aPI3K\u6291\u5236\u5242idelalisib\u4e0ecopanlisib\u88abFDA\u6279\u51c6\u4e0a\u5e02<\/strong><\/span>\u3002<\/span><\/p>\n


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\u867d\u7136\u8fd9\u7c7b\u65b0\u578b\u6291\u5236\u5242\u5c1a\u672a\u7814\u7a76\u6210\u719f\uff0c\u4ecd\u6709\u5f88\u591a\u95ee\u9898\u9700\u8981\u89e3\u51b3\uff0c\u4f46\u662f\u4ece\u76ee\u524d\u60c5\u51b5\u6765\u770b\uff0c\u5b83\u4eec\u8fd8\u662f\u6709\u7740\u660e\u663e\u7684\u4f18\u70b9\uff0c\u8be5\u7c7b\u836f\u7269\u53ef\u4ee5\u5229\u7528\u751f\u7269\u6807\u5fd7\u7269\u6765\u786e\u5b9a\u7528\u836f\uff0c\u4ee5\u6ee1\u8db3\u4e2a\u4f53\u5316\u4e0e\u7cbe\u51c6\u6cbb\u7597\u3002\u4e0b\u9762\u8ba9\u6211\u4eec\u8be6\u7ec6\u4e86\u89e3\u8be5\u7c7b\u6291\u5236\u5242\u3002<\/span><\/p>\n


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mTOR\u6291\u5236\u5242<\/span><\/strong><\/span><\/p>\n<\/section>\n

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mTOR\u662f\u4e1d\u6c28\u9178\u548c\u82cf\u6c28\u9178\u86cb\u767d\u6fc0\u9176\uff0c\u5177\u6709\u4e24\u79cd\u86cb\u767d\u8d28\u590d\u5408\u7269\u4e9a\u578b\uff0cmTORC1\u4e0emTORC2\u3002mTOR\u901a\u8def\u662f\u54fa\u4e73\u52a8\u7269\u4ee3\u8c22\u8c03\u8282\u7684\u4e2d\u67a2\uff0c\u53c2\u4e0e\u591a\u79cd\u7ec6\u80de\u4e0e\u7ec4\u7ec7\u7684\u751f\u7406\u6d3b\u52a8\u3002\u6d3b\u5316mTORC1\u4f7f\u5176\u4e0b\u6e38\u901a\u8defPI3K\u548cAKT\u589e\u52a0\u86cb\u767d\u8d28\u3001\u8102\u8d28\u548c\u6838\u82f7\u9178\u7684\u5408\u6210\uff0c\u51cf\u5c11\u7ec6\u80de\u81ea\u566c\uff1bmTORC2\u4e5f\u662f\u901a\u8fc7\u8c03\u8282\u4e0b\u6e38\u6fc0\u9176\u5ef6\u957f\u7ec6\u80de\u5bff\u547d\u3002mTOR\u6291\u5236\u5242\u4e3b\u8981\u5305\u62ec\u53d8\u6784mTOR\u6291\u5236\u5242(Allosteric mTOR inhibitors)\u4e0emTOR\u6fc0\u9176\u6291\u5236\u5242(mTOR kinase inhibitors)\u3002<\/span>
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Temsirolimus\u662f\u53d8\u6784mTOR\u6291\u5236\u5242\u96f7\u5e15\u9709\u7d20\u7684\u524d\u836f\uff0c\u53ef\u4ee5\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u53d1\u6325\u836f\u6548\u30022007\u5e74\uff0c\u7531\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c(RCC)\u3002Temsirolimus\u4e0eFKBP-12\u86cb\u767d\u7ed3\u5408\uff0c\u5f62\u6210\u7684\u86cb\u767d-\u836f\u7269\u590d\u5408\u7269\uff0c\u6291\u5236 mTOR \u63a7\u5236\u7ec6\u80de\u5206\u88c2\uff0c \u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u5728 G1\u671f\u751f\u957f\u505c\u6ede\u3002\u5728\u80be\u7ec6\u80de\u764c\u7ec6\u80de\u682a\u7684\u4f53\u5916\u8bd5\u9a8c\u4e2d\uff0c\u8be5\u836f\u53ef\u6291\u5236 mTOR \u7684\u6d3b\u6027\uff0c\u5bfc\u81f4\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50 HIF-1\u3001HIF-2\u03b1\u53ca\u8840\u7ba1\u5185\u76ae \u751f\u957f\u56e0\u5b50\u7684\u6c34\u5e73\u964d\u4f4e\u3002Everolimus\u662f\u53e6\u4e00\u79cd\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\uff0c\u4e8e2009\u5e74\u7531\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\u3002\u8be5\u836f\u53ef\u4ee5\u7528\u4e8e\u591a\u79cd\u764c\u75c7\u7684\u6cbb\u7597\uff0c\u5305\u62ec\u665a\u671f\u80be\u7ec6\u80de\u764c\u3001\u505c\u7ecf\u540e\u4e73\u817a\u764c\u3001\u80f0\u817a\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u7b49\u3002\u4e0e\u767d\u86cb\u767d\u7ed3\u5408\u7684\u96f7\u5e15\u9709\u7d20\u7eb3\u7c73\u5fae\u7c92\u6ce8\u5c04\u5242\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8cII\u671f\uff0c\u7814\u7a76\u8868\u660e\uff0c\u8be5\u836f\u5bf9\u4f4e\u78f7\u8840\u75c7\u3001\u8d2b\u8840\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u6709\u6cbb\u7597\u4f5c\u7528\uff0c\u5bf9\u665a\u671f\u80be\u7ec6\u80de\u764c\u6709\u90e8\u5206\u5e94\u7b54\u3002<\/span><\/p>\n


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\u975e\u53d8\u6784mTOR\u6291\u5236\u5242\u53ef\u4ee5\u7ade\u4e89\u6027\u5730\u6291\u5236mTOR\u6fc0\u9176\uff0c\u5305\u62ecmTORC1 \u4e0emTORC2\uff0c\u6240\u4ee5\u4e5f\u53ebmTOR\u6fc0\u9176\u6291\u5236\u5242\u3002\u8be5\u7c7b\u6291\u5236\u5242\u53ef\u4ee5\u963b\u6b62\u7531 mTORC1\u6291\u5236\u5242\u9020\u6210\u7684AKT\u6d3b\u5316\u5f62\u6210\u7684\u53cd\u9988\u8c03\u8282\uff0c\u6240\u4ee5\uff0c\u8be5\u7c7b\u836f\u7269\u6bd4mTORC1\u6291\u5236\u5242\u5177\u6709\u66f4\u5f3a\u7684\u6291\u5236\u6548\u679c\u3002<\/span><\/p>\n


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\"PI3K\u6291\u5236\u5242\u2014\u2014\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u9009\u62e9\"<\/p>\n

PI3K\u2013AKT\u2013mTOR\u4fe1\u53f7\u8f6c\u5bfc\u793a\u610f\u56fe<\/span><\/p>\n


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Vistusertib\u662fmTORC1 \u4e0emTORC2\u6291\u5236\u5242\uff0c \u4e3b\u8981\u96c6\u4e2d\u5728\u5bf9\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u4e0e\u4e73\u817a\u764c\u7684\u7814\u7a76\uff0c\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8cII\u671f\uff0c\u7814\u7a76\u663e\u793a\uff0c\u8be5\u836f\u4e0efulvestrant\u76f8\u6bd4\uff0c\u5374\u672a\u80fd\u8bc1\u660e\u5bf9\u96cc\u6fc0\u7d20\u53d7\u4f53(ER)\u9633\u6027\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u6709\u76ca\u3002Sapanisertib\u4e5f\u4e3a\u53e3\u670dmTORC1\/2\u53cc\u91cd\u6291\u5236\u5242\uff0c\u5df2\u901a\u8fc7\u4e34\u5e8a\u8bd5\u9a8cI\u671f\u7684\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\u8bc4\u4ef7\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u591a\u79cd\u5b9e\u4f53\u7624\u3001\u6dcb\u5df4\u7624\u3001\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u4e34\u5e8a\u8bd5\u9a8cII MATCH\u671f\u7814\u7a76\u3002\u4e5f\u6709\u5176\u4ed6mTORC1\/2\u6291\u5236\u5242\u5904\u4e8e\u5f00\u53d1\u4e2d\uff0c\u4f46\u5b83\u4eec\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6548\u679c\u5374\u4e0d\u5c3d\u7406\u60f3\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u7406\u8bba\u4e0a\uff0cmTOR\u6fc0\u9176\u6291\u5236\u5242\u5177\u6709\u53cc\u91cd\u6291\u5236mTORC1\/2\u7684\u6548\u679c\uff0c\u4e5f\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4f46\u662f\u5728\u5b9e\u9645\u4e34\u5e8a\u7814\u7a76\u4e2d\u5374\u4e0d\u80fd\u8868\u73b0\u51fa\u66f4\u597d\u7684\u6d3b\u6027\u3002<\/span><\/strong><\/span>mTORC1\u6291\u5236\u5242\u5df2\u4e0a\u5e02\u591a\u5e74\uff0c\u5176\u6cbb\u7597\u6548\u529b\u5df2\u5f97\u5230\u5145\u5206\u7684\u8bc1\u660e\u3002\u5c06\u6765\u54ea\u79cd\u6291\u5236\u5242\u4f1a\u66f4\u80dc\u4e00\u7b79\uff0c\u76ee\u524d\u4ecd\u662f\u96fe\u91cc\u770b\u82b1\u3002<\/span><\/p>\n


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Pan\u2011PI3K \u6291\u5236\u5242<\/span><\/strong><\/span><\/strong><\/span><\/p>\n<\/section>\n

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Pan\u2011PI3K \u6291\u5236\u5242\u76ee\u524d\u6291\u52364\u79cdPI3K\u4e9a\u578b\uff0c\u5373PI3K\u03b1\u3001PI3K\u03b2 \u3001PI3K\u03b3\u4e0e PI3K\u03b4\u3002\u8fd9\u4e9b\u5316\u5408\u7269\u5177\u6709\u5e7f\u8c31\u7684\u6d3b\u6027\uff0c\u4f46\u4e5f\u5177\u6709\u8131\u9776\u98ce\u9669\u4e0e\u6bd2\u6027\u3002\u76ee\u524d\uff0c\u9664\u4e86copanlisib\u4e4b\u5916\uff0c\u7531\u4e8e\u6d3b\u6027\u95ee\u9898\u6216\u5b89\u5168\u6027\u8003\u8651\uff0c\u6ca1\u6709panPI3K\u6291\u5236\u5242\u88ab\u6279\u51c6\u7528\u4e8e\u4e34\u5e8a\u3002<\/span>
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Buparlisib\u7531Novartis\u516c\u53f8\u7814\u53d1\uff0c\u662f\u4e00\u79cd\u53ef\u53e3\u670d\u7684\u9ad8\u6548\u7684panPI3K\u6291\u5236\u5242\uff0c\u4e5f\u662f\u76ee\u524d\u7ecf\u5386\u6d4b\u8bd5\u6700\u591a\u7684Pan-PI3K\u6291\u5236\u5242\u3002\u5728III\u671fBELLE\u00ad2\u8bd5\u9a8c\u6570\u636e\u663e\u793a\uff0c\u8054\u7528buparlisib \u4e0efulvestrant\u53ef\u4ee5\u589e\u52a0\u7edd\u7ecf\u540e\u4e73\u817a\u764c\u60a3\u8005\u7684\u751f\u5b58\u7387\u3002<\/span><\/p>\n


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BGT226\u662fPan\u2011PI3K\u4e0emTOR\u7684\u53cc\u91cd\u6291\u5236\u5242\uff0c\u76ee\u524d\u5df2\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8cI\u671f\u3002\u7406\u8bba\u4e0a\uff0c\u53cc\u91cd\u6291\u5236\u5242\u4f1a\u6709\u66f4\u5f3a\u7684\u6291\u5236\u6548\u679c\uff0c\u4f46\u662f\u4e0d\u51fa\u610f\u5916\u7684\u8bdd\uff0c\u8fd9\u7c7b\u836f\u7269\u7684\u6bd2\u6027\u4e5f\u662f\u6210\u500d\u589e\u52a0\u3002<\/span><\/strong><\/span><\/p>\n


<\/span><\/strong><\/span><\/p>\n

PI3K\u03b1\u662fPI3K\u56db\u4e2a\u4e9a\u57fa\u4e4b\u4e00\uff0c\u5728PI3K\u901a\u8def\u4e2d\u8d77\u5230\u91cd\u8981\u4f5c\u7528\uff0c\u76ee\u524d\uff0c\u5df2\u6709\u591a\u4e2a\u6291\u5236\u5242\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u3002Alpelisib\u7531Novartis\u516c\u53f8\u7814\u53d1\uff0c\u76ee\u524d\u5df2\u8fdb\u5165\u4e34\u5e8aIII\u671f\u7814\u7a76\uff0c\u4e3b\u8981\u7528\u4e8e\u4e73\u817a\u764c\u7684\u6cbb\u7597\u3002\u5176\u4ed6PI3K\u03b1\u6291\u5236\u5242\u4e5f\u9646\u7eed\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\uff0cTakeda\u516c\u53f8\u7684TAK-117\u4e0eRoche\u516c\u53f8\u7684GDC-0077\/ RG6114\uff0c\u5c06\u662fAlpelisib\u7684\u6709\u529b\u7ade\u4e89\u8005\u3002<\/span><\/p>\n


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\u4f5c\u4e3aPI3K\u03b2\u6291\u5236\u5242\u7684GSK2636771\uff0c\u7528\u4e8e\u6cbb\u7597PTEN\u5b9e\u4f53\u7624\uff0c\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8cI\/IIa FTIH \u7814\u7a76\u4e2d\u3002\u53e6\u4e00\u79cdPI3K\u03b2\u6291\u5236\u5242\uff0cSAR260301\u5bf9\u591a\u79cd\u665a\u671f\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\u6b63\u5728\u7814\u7a76\u4e2d\uff0c\u836f\u52a8\u5b66\u8868\u660e\uff0cSAR260301\u5728\u4f53\u5185\u6392\u51fa\u8fc5\u901f\uff0c\u4e0d\u80fd\u4f5c\u4e3a\u957f\u6548\u7684\u6291\u5236\u5242\u3002<\/span><\/p>\n


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PI3K\u03b3\u6291\u5236\u5242\u4e0d\u4ec5\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4e5f\u53ef\u4ee5\u589e\u52a0\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u6d3b\u6027\uff0c\u6062\u590d\u80bf\u7624\u7ec6\u80de\u5bf9\u514d\u75ab\u7ec6\u80de\u7684\u654f\u611f\u6027\u3002IPI\u00ad549\u662f\u4e00\u79cd\u53e3\u670d\u7684PI3K\u03b3\u6291\u5236\u5242\uff0c\u5355\u72ec\u4f7f\u7528\u6216\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242nivolumab\u8054\u7528\uff0c\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u764c\u75c7\u6216\u8005\u9ed1\u8272\u7d20\u7624\u3002<\/span><\/p>\n


<\/span><\/p>\n

PI3K\u03b4\u5728B\u7ec6\u80de\u4fe1\u53f7\u8f6c\u5bfc\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\uff0c\u5728\u591a\u79cd\u8840\u6db2\u6076\u6027\u80bf\u7624\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272\u3002\u76ee\u524dPI3K\u03b4\u9009\u62e9\u6027\u6291\u5236\u5242idelalisib\u5df2\u83b7\u6279\u51c6\uff0c\u4e0erituximab\u8054\u7528\uff0c\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5(CLL)\u3002Duvelisib\u662f\u53e6\u4e00\u79cd\u9ad8\u6548\u7684PI3K\u03b3\u4e0e PI3K\u03b4\u6291\u5236\u5242\uff0c\u76ee\u524d\u5df2\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8cIII\u671f\u3002<\/span><\/p>\n


<\/span><\/p>\n

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AKT\u6291\u5236\u5242<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

AKT\uff0c\u53c8\u79f0\u4e3a\u86cb\u767d\u6fc0\u9176 B(PKB)\uff0c\u662f\u4e00\u7c7b\u4e1d\u6c28\u9178 \/\u82cf\u6c28\u9178\u6fc0\u9176\uff0c\u5c5e\u4e8eAGC\u6fc0\u9176\u5bb6\u65cf\uff0c\u4e0e PKA(\u86cb\u767d\u6fc0\u9176A)\u548c PKC(\u86cb\u767d\u6fc0\u9176C)\u5177\u6709\u9ad8\u5ea6\u540c\u6e90\u6027\u3002AKT\u5305\u542b3\u79cd\u4e9a\u578b\uff1aAKT1\u3001AKT2 \u548c AKT3\uff0c\u6bcf\u79cd\u4e9a\u578b\u90fd \u6709\u72ec\u7279\u7684\u529f\u80fd\u548c\u8868\u8fbe\u56fe\u8c31\u3002AKT<\/span>\u6709\u8bb8\u591a\u7ed3\u5408\u4f4d\u70b9\uff0c \u5f71\u54cdmTORC1\u7684\u6d3b\u6027\uff0c\u8fdb\u800c\u8c03\u8282\u4e0b\u6e38\u7684PI3K-AKT-mTOR\u4fe1\u53f7\u901a\u8def\u3002<\/span>
<\/p>\n


<\/span><\/p>\n

MK\u00ad2206\u5177\u6709\u6291\u5236AKT1\u3001AKT2\u7684\u6d3b\u6027\uff0c\u8f83\u5c11\u5730\u6291\u5236AKT3\u3002\u4e34\u5e8a\u7814\u7a76\u53d1\u73b0\uff0c\u8be5\u836f\u5bf9\u665a\u671f\u5b9e\u4f53\u7624\u5e76\u65e0\u660e\u663e\u54cd\u5e94\uff1b\u5728\u4e00\u9879\u4e73\u817a\u764c\u7814\u7a76\u4e2d\uff0cMK\u00ad2206\u53ef\u4ee5\u6539\u5584\u60a3\u8005\u7684CR\u7387\u3002Miransertib\u662f\u53e6\u4e00\u79cdAKT\u6291\u5236\u5242\uff0c\u5bf9\u591a\u79cd\u5b9e\u4f53\u7624\u7684\u4f5c\u7528\u6b63\u5728\u7814\u7a76\u4e2d\u3002ARQ 751\u4f5c\u4e3a\u4e0b\u4e00\u4ee3\u53d8\u6784Pan-AKT\u6291\u5236\u5242\u4e0eMiransertib\u6709\u8f83\u5927\u7684\u5dee\u522b\uff0c\u76ee\u524d\u5df2\u7ecf\u8fdb\u884c\u4e86\u5bf9\u591a\u79cd\u5b9e\u4f53\u7624\u7684\u5242\u91cf\u7814\u7a76\uff0c\u4e34\u5e8a\u524d\u8bd5\u9a8c\u8868\u660e\uff0c\u8be5\u836f\u5bf9\u591a\u79cd\u86cb\u767dPIK3CA\u3001PIK3R\u3001AKT1E17K\u3001PTEN\u5177\u6709\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528\u3002\u53e6\u5916\uff0c\u6709TAS\u00ad117\u4f5c\u4e3a\u975eATP\u7ade\u4e89\u6027AKT\u6291\u5236\u5242\u6b63\u5904\u5728\u4e34\u5e8aI\u671f\u7814\u7a76\u4e2d\uff0cUprosertib\u4f5c\u4e3aATP\u7ade\u4e89\u6027AKT\u6291\u5236\u5242\u4e5f\u5904\u4e8e\u4e34\u5e8aI\u671f\uff0c\u6b63\u5f00\u5c55\u591a\u79cd\u665a\u671f\u5b9e\u4f53\u7624\u8bd5\u9a8c\u7814\u7a76\u3002<\/span><\/p>\n


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\u5c55\u671b<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n<\/section>\n

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\u76ee\u524d\uff0c\u5927\u591a\u6570PI3K\u2013AKT\u2013mTOR\u901a\u8def\u6291\u5236\u5242\u867d\u5df2\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f46\u5bf9\u5176\u4e2d\u7684\u4e00\u4e9b\u95ee\u9898\u4ecd\u5904\u4e8e\u4e89\u8bba\u72b6\u6001\uff0c\u4e4b\u540e\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u5c06\u4f1a\u5448\u73b0\u7b54\u6848\u3002\u76ee\u524d\uff0c\u591a\u91cd\u6291\u5236\u5242\u4e0e\u5355\u4e00\u6291\u5236\u5242\u8fd9\u4e24\u7c7b\u836f\u7269\u7684\u6cbb\u7597\u6548\u679c\u4ecd\u5728\u4e89\u8bba\u4e4b\u4e2d\uff0c\u5bf9\u4e8e\u8be5\u7c7b\u836f\u7269\u7684\u5b89\u5168\u6027\u4e0e\u6bd2\u6027\u76ee\u524d\u8ba4\u77e5\u4e5f\u6bd4\u8f83\u5c11\uff0c\u5bf9\u4e8e\u7814\u53d1\u4f4e\u6bd2\u9ad8\u6548\u7684\u836f\u7269\u4ecd\u6709\u5f88\u957f\u7684\u63a2\u7d22\u4e4b\u8def\u3002<\/span>
<\/p>\n


<\/span><\/p>\n

\u53c2\u8003\u8d44\u6599<\/span><\/p>\n

1.Targeting the PI3K pathway in cancer: are we making headway?<\/span><\/p>\n

2.Seeking alpha in PI3K inhibition.<\/span><\/p>\n

3.Pi3K inhibitors as new cancer therapeutics: implications for clinicaltrial design.<\/span><\/p>\n

4.Novel Molecular-targeted Antitumor Drugs-PI3K Inhibitor.<\/span><\/p>\n


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\"PI3K\u6291\u5236\u5242\u2014\u2014\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u9009\u62e9\"<\/section>\n<\/section>\n

2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5<\/span><\/a>
<\/p>\n

2018\u5e747\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5<\/span><\/a>
<\/p>\n

\u4e73\u817a\u764c\u6700\u6709\u6f5c\u529b\u9776\u70b9\u2014\u2014CDK4\/6\u6291\u5236\u5242\u76d8\u70b9\u4e0e\u89e3\u6790<\/span><\/a>
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\u836f\u6e21APP\u5168\u9762\u5347\u7ea7\u5566\uff01\u4e00\u89c8\u5168\u7403\u83b7\u6279\u65b0\u836f\uff0c\u4e2d\u56fd\u4e34\u5e8a\u9879\u76ee\uff0c\u884c\u4e1a\u878d\u8d44\u4fe1\u606f\uff0c\u5b9e\u65f6\u66f4\u65b0\uff0c\u5168\u8986\u76d6\uff01<\/span><\/a>
<\/p>\n

\u67e5\u836f\u4f01\u3001\u627e\u533b\u836f\u56ed\u533a\uff1f\u4e0a\u836f\u6e21App<\/span><\/a>
<\/p>\n

\u201c\u836f\u5408\u6210\u201d\u4e00\u7ad9\u5f0f\u89e3\u51b3\u533b\u836f\u7814\u53d1\u8005\u4fe1\u606f\u9700\u6c42<\/span><\/a>
<\/p>\n<\/section>\n<\/section>\n


<\/p>\n

\"PI3K\u6291\u5236\u5242\u2014\u2014\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u9009\u62e9\"<\/span><\/a><\/p>\n

\"PI3K\u6291\u5236\u5242\u2014\u2014\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u9009\u62e9\"<\/span><\/a><\/p>\n

\"PI3K\u6291\u5236\u5242\u2014\u2014\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u9009\u62e9\"<\/p>\n

\"PI3K\u6291\u5236\u5242\u2014\u2014\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u9009\u62e9\"<\/p>\n

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\u7acb\u5373\u89e3\u9501\u4f60\u7684\u638c\u4e0a\u4e13\u4e1a\u5de5\u5177\uff01<\/span><\/p>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u5728\u4eba\u7c7b\u80bf\u7624\u7ec6\u80de\u4e2d\uff0cPI3K\u2013AKT\u2013mTOR\u4fe1\u53f7\u901a\u8def\u662f\u6700\u5e38\u89c1\u7684\u5931\u8c03\u901a\u8def\u3002\u4f46\u8fd9\u6761\u901a\u8def\u53c8\u662f\u5982\u6b64\u91cd\u8981\uff0c\u6d89\u53ca\u5230\u6b63\u5e38\u7ec6\u80de […]<\/p>\n","protected":false},"author":1,"featured_media":49311,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49310"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=49310"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49310\/revisions"}],"predecessor-version":[{"id":49319,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49310\/revisions\/49319"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/49311"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=49310"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=49310"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=49310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}