{"id":49371,"date":"2018-09-18T01:00:00","date_gmt":"2018-09-26T01:57:48","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/2018%e5%b9%b48%e6%9c%88%e5%85%a8%e7%90%83%e6%89%b9%e5%87%86%e6%96%b0%e8%8d%af%e6%a6%82%e5%86%b5\/"},"modified":"2018-09-26T09:58:00","modified_gmt":"2018-09-26T01:58:00","slug":"2018%e5%b9%b48%e6%9c%88%e5%85%a8%e7%90%83%e6%89%b9%e5%87%86%e6%96%b0%e8%8d%af%e6%a6%82%e5%86%b5","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/49371\/","title":{"rendered":"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"__bg_gif\"     width=\"auto\" style=\"font-size: 16px;white-space: normal;color: rgb(62, 62, 62);line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537927069.gif\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">2018\u5e748\u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40FDA\u5171\u6279\u51c65\u4e2a\u65b0\u5206\u5b50\u5b9e\u4f53\u836f\u7269\uff08NME\uff09<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\uff0c\u5206\u522b\u662f\u6cbb\u7597\u8f6c\u7532\u72b6\u817a\u7d20\u86cb\u767d\u5bb6\u65cf\u6027\u6dc0\u7c89\u6837\u591a\u53d1\u6027\u795e\u7ecf\u75c5\u7684Patisiran\u3001\u6cbb\u7597\u590d\u6742\u8179\u8154\u611f\u67d3\u7684Eravacycline\u3001\u6cbb\u7597\u827e\u6ecb\u75c5\u7684Doravirine\u3001\u6cbb\u7597\u827e\u6ecb\u75c5\u7684\u590d\u65b9\u836f\u7269Doravirine\/ Lamivudine\/ Tenofovir Disoproxil Fumarate\u548c\u7528\u4e8e\u5973\u6027\u907f\u5b55\u7684\u590d\u65b9\u836f\u7269\u918b\u9178\u70ef\u8bfa\u5b55\u916e\/\u7094\u96cc\u9187\uff08Nestorone Acetate\/ Ethinyl Estradiol\uff09\u3002<\/span><strong><span style=\"font-size: 15px;color: rgb(0, 128, 255);\">FDA\u9996\u62792\u4e2a\u751f\u7269\u5236\u54c1\uff0c<\/span><\/strong><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u5206\u522b\u662f\u6cbb\u7597\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf\u7684Lanadelumab\u5355\u6297\u3001\u6cbb\u7597\u8840\u53cb\u75c5A\u7684Damoctocog alfa pegol\u3002<\/span><strong><span style=\"color: rgb(0, 128, 255);font-size: 15px;\">\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40NMPA\uff08\u539fCFDA\uff09\u6279\u51c61\u4e2a1\u7c7b\u65b0\u836f\uff0c<\/span><\/strong><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u5373\u6cbb\u7597HER2\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\uff08Pyrotinib Maleate\uff09\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537927070.jpg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section  label=\"Powered by 135editor.com\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 1.5px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);text-align: justify;\"><span class=\"autonum\"  placeholder=\"1\" style=\"color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);word-wrap: break-word !important;\" title=\"\">1<\/span><span style=\"font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\">Patisiran<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537927070.jpg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">Patisiran\u4e8e2018\u5e748\u670810\u65e5\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\uff0c\u7528\u4e8e\u6cbb\u7597\u8f6c\u7532\u72b6\u817a\u7d20\u86cb\u767d\u5bb6\u65cf\u6027\u6dc0\u7c89\u6837\u591a\u53d1\u6027\u795e\u7ecf\u75c5\uff08hATTR amyloidosis\uff09\u6210\u4eba\u60a3\u8005\uff0c\u5546\u54c1\u540d\u4e3a<\/span><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>Onpattro<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002Patisiran\u6700\u521d\u7531Alnylam Pharmaceuticals\u7814\u53d1\uff0c2012\u5e74\u6388\u6743\u7ed9\u5065\u8d5e\uff08\u8d5b\u8bfa\u83f2\u5b50\u516c\u53f8\uff09\u3002\u8be5\u5316\u5408\u7269\u5206\u522b\u5728\u6b27\u76df\uff082011\u5e74\uff09\u3001\u7f8e\u56fd\uff082017\u5e74\uff09\u83b7\u5f97\u7528\u4e8e\u6cbb\u7597\u6dc0\u7c89\u6837\u591a\u53d1\u6027\u795e\u7ecf\u75c5\u7684\u5b64\u513f\u836f\u8d44\u683c<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[1]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">\u8f6c\u7532\u72b6\u817a\u7d20\u86cb\u767d\u5bb6\u65cf\u6027\u6dc0\u7c89\u6837\u591a\u53d1\u6027\u795e\u7ecf\u75c5<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\uff08hATTR amyloidosis\uff09\u662f\u4e00\u79cd\u5e38\u67d3\u8272\u4f53\u663e\u6027\u7a81\u53d8\u75be\u75c5\uff0c\u5177\u6709\u786e\u8bca\u96be\u5ea6\u5927\u3001\u8fdb\u5c55\u901f\u5ea6\u5feb\u548c\u81f4\u547d\u7684\u7279\u70b9\u3002\u6b63\u5e38TTR\u86cb\u767d\u7531\u809d\u810f\u5408\u6210\uff0c\u5e76\u8d1f\u8d23\u7ef4\u4ed6\u547dA\u7684\u8f6c\u8fd0\u3002\u7a81\u53d8\u5bfc\u81f4TTR\u86cb\u767d\u9519\u8bef\u6298\u53e0\uff0c\u5e76\u4ee5\u6dc0\u7c89\u6837\u7ea4\u7ef4\u7684\u5f62\u5f0f\u6c89\u79ef\u5728\u795e\u7ecf\u7cfb\u7edf\u3001\u5fc3\u810f\u3001\u80a0\u80c3\u9053\u7b49\u5668\u5b98\u7ec4\u7ec7\uff0c\u9020\u6210\u75c5\u4eba\u611f\u89c9\u3001\u8fd0\u52a8\u548c\u81ea\u4e3b\u795e\u7ecf\u529f\u80fd\u969c\u788d\u3002\u76ee\u524d\uff0c\u5df2\u53d1\u73b0\u4e86\u5bfc\u81f4\u8be5\u75c5\u7684120\u591a\u79cd\u57fa\u56e0\u7a81\u53d8\uff0c\u5177\u6709\u660e<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u663e\u7684\u79cd\u65cf\u548c\u5730\u57df\u5206\u5e03\u7279\u70b9\u3002hATTR\u75c5\u53d8\u5f71\u54cd\u7740\u4e16\u754c\u4e0a50000\u591a\u4f4d\u75c5\u4eba\uff0c\u9664\u6b64\u4e4b\u5916\uff0c\u5c1a\u5b58\u5728\u5f88\u591a\u672a\u786e\u8bca\u6216\u8bef\u8bca\u4e3a\u5176\u4ed6\u75c5\u7684\u6f5c\u5728\u60a3\u8005<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[2<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537927071.jpg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">Patisiran\u662f\u4e00\u79cd\u9776\u5411TTR\u4fe1\u4f7fRNA \uff08TTR mRNA\uff09\u7684\u53cd\u4e49\u5be1\u6838\u82f7\u9178\uff08ASO\uff09\uff0c<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u53ef\u4ee5\u6291\u5236\u4eba\u8f6c\u7532\u72b6\u817a\u7d20\u86cb\u767d\uff08TTR\uff09\u7684\u751f\u6210\u3002Patisiran\u9009\u62e9\u6027\u7ed3\u5408\u5e76\u964d\u89e3TTR mRNA\uff0c\u4f7f\u5f97\u8840\u6e05\u4e2d\u7684TTR\u86cb\u767d\u542b\u91cf\u53ca\u7ec4\u7ec7\u4e2d\u6c89\u79ef\u7684TTR\u542b\u91cf\u660e\u663e\u51cf\u5c11<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[3]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">Pattisiran\u7684\u83b7\u6279\u662f\u57fa\u4e8e\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u4e34\u5e8a\u4e09\u671f\u8bd5\u9a8c\uff08NCT 01960348\uff09\uff0c<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u7eb3\u5165225\u4e2a\u75c5\u4eba\uff08Pattisiran\u548c\u5b89\u6170\u52422:1\u5206\u7ec4\uff09\uff0c\u5386\u65f618\u4e2a\u6708\u3002\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u4e3a\u6539\u826f\u795e\u7ecf\u75c5\u53d8\u635f\u5bb3\u8bc4\u5206\uff08mNIS+7\uff09\uff0c\u6b21\u8981\u7ec8\u70b9\u4e3aNorfolk\u7cd6\u5c3f\u75c5\u795e\u7ecf\u75c5\u53d8\u751f\u6d3b\u8d28\u91cf\u8bc4\u5206\uff08Norfolk QoL-DN\uff09\u300110\u7c73\u6b65\u884c\u6d4b\u8bd5\u3001\u4f53\u91cd\u6307\u6570mBMI\u3002\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff1aPatisiran\u548c\u5b89\u6170\u5242\u7ec4\u7684mNIS+7\u8bc4\u5206\u5dee\u503c\u8fbe-34.0\u5206\uff08p&lt;0.001\uff09\uff0cNorfolk QoL-DN\u5dee\u503c\u4e3a-21.1\uff08p&lt;0.001\uff09\uff0c10\u7c73\u6b65\u884c\u5dee\u503c\u4e3a0.31\uff08p&lt;0.001\uff09\uff0c\u4f53\u91cd\u6307\u6570mBMI\u5dee\u503c\u4e3a116\uff08p&lt;0.001\uff09\u3002Patisiran\u6cbb\u7597\u7ec4\u7684\u4e3b\u8981\u548c\u6b21\u8981\u7ec8\u70b9\u5747\u5f97\u5230\u663e\u8457\u6539\u5584<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[4]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">Patisiran\u4f5c\u4e3a\u7f8e\u56fd\u9996\u4e2a\u6279\u51c6\u7528\u4e8e\u6cbb\u7597hATTR\u7684RNAi\u836f\u7269\uff0c\u4e0e\u6b27\u76df\u6279\u51c6\u7684Inotersen\u4e00\u8d77\u4e3aRNAi\u836f\u7269\u7684\u7814\u53d1\u63d0\u4f9b\u4e86\u66f4\u591a\u7684\u501f\u9274\u610f\u4e49\u3002<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u5bf9\u4e8e\u57fa\u56e0\u7a81\u53d8\u4f4d\u70b9\u8f83\u591a\u4ee5\u53ca\u96be\u4ee5\u6210\u4e3a\u9776\u70b9\u7684\u86cb\u767d\u8d28\uff0c\u53ef\u4ee5\u5c06mRNA\u4f5c\u4e3a\u836f\u7269\u9776\u70b9\uff0c\u5229\u7528\u9776\u5411RNAi\u6280\u672f\u8fdb\u884c\u6cbb\u7597\u3002\u4ece\u4e0a\u4e16\u7eaa90\u5e74\u4ee3RNAi\u5e72\u6270\u73b0\u8c61\u7684\u53d1\u73b0\uff0c\u5230\u9996\u4e2a\u57fa\u4e8eRNAi\u7684\u836f\u7269\u83b7\u6279\uff0c\u7528\u4e86\u5c06\u8fd130\u5e74\u7684\u65f6\u95f4\u3002Intersen\u548cPatisran\u7684\u83b7\u6279\uff0c\u610f\u5473\u7740RNAi\u836f\u7269\u7684\u65f6\u4ee3\u5df2\u7ecf\u5230\u6765\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section  label=\"Powered by 135editor.com\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 1.5px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);text-align: justify;\"><span class=\"autonum\"  placeholder=\"1\" style=\"color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);word-wrap: break-word !important;\" title=\"\">2<\/span><span style=\"font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\">Nestorone Acetate\/Ethinyl Estradiol<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"width: 340px;height: 125px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537927071.png\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;\">Nestorone Acetate\/ Ethinyl Estradiol\uff08\u918b\u9178\u70ef\u8bfa\u5b55\u916e\/\u7094\u96cc\u9187\uff09\u4f5c\u4e3a\u590d\u65b9\u836f\u7269\uff0c<\/span><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">\u4e8e2018\u5e748\u670810\u65e5\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\uff0c<\/span><\/strong><\/span><span style=\"font-size: 15px;\">\u7528\u4e8e\u9884\u9632\u610f\u5916\u6000\u5b55\uff0c\u5546\u54c1\u540d\u4e3a<\/span><strong><span style=\"color: rgb(0, 128, 255);font-size: 15px;\">Annovera<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><\/strong><span style=\"font-size: 15px;\">\u3002\u5176\u4e2d\uff0cNestorone Acetate\u662f\u9996\u6b21\u4f5c\u4e3aNME\u5206\u5b50\u83b7\u6279\u3002Annovera<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"font-size: 15px;\">\u7531Population Council\u7814\u53d1\u9500\u552e<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[5]<\/span><\/sup><\/span><span style=\"font-size: 15px;\">\u3002<\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u5728\u7f8e\u56fd\u7ea6\u6709\u4e00\u534a\u4ee5\u4e0a\u7684\u6000\u5b55\u5c5e\u4e8e\u610f\u5916\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4\u5b55\u5987\u672a\u80fd\u53ca\u65f6\u63a5\u53d7\u4ea7\u68c0\uff0c\u4f4e\u51fa\u751f\u4f53\u91cd\u513f\u589e\u591a\uff0c\u4e25\u91cd\u5f71\u54cd\u6bcd\u5a74\u7684\u8eab\u5fc3\u5065\u5eb7\u3002\u6b64\u5916\uff0c\u610f\u5916\u6000\u5b55\u8fd8\u4f1a\u589e\u52a0\u4e2d\u4f4e\u6536\u5165\u5bb6\u5ead\u7684\u7ecf\u6d4e\u8d1f\u62c5\u3002\u957f\u6548\u907f\u5b55\u836f\u7269\u53ef\u4ee5\u589e\u52a0\u5973\u6027\u7684\u9009\u62e9\uff0c\u5bf9\u4e8e\u8d44\u6e90\u532e\u4e4f\u7684\u5730\u533a\u5c24\u4e3a\u91cd\u8981<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[6]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537927071.jpg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">Nestorone Acetate\uff08\u918b\u9178\u70ef\u8bfa\u5b55\u916e\uff09\u662f\u4e00\u79cd\u5b55\u6fc0\u7d20\u53d7\u4f53\u6291\u5236\u5242\uff0c\u901a\u8fc7\u6291\u5236\u6392\u5375\u5b9e\u73b0\u907f\u5b55\u4f5c\u7528\u3002Ethinyl Estradiol\uff08\u7094\u96cc\u9187\uff09\u53ef\u4ee5\u589e\u5f3aNestorone Acetate\uff08\u918b\u9178\u70ef\u8bfa\u5b55\u916e\uff09\u7684\u907f\u5b55\u6548\u679c\uff0c\u5e76\u9632\u6b62\u5b50\u5bab\u5185\u819c\u4e0d\u89c4\u5219\u8131\u843d<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[7]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">Annovera<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup>\u7684\u83b7\u6279\u662f\u57fa\u4e8e\u4e24\u9879\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u4e09\u671f\u8bd5\u9a8c\uff0c\u7eb3\u516518~40\u5c81\u80b2\u9f84\u5987\u5973\u5171\u8ba12308\u4f4d\uff0c\u8bd5\u9a8c\u5468\u671f1\u5e74\uff08NCT00263341\uff0cNCT00455156\uff09\u3002<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u7ed3\u679c\u663e\u793a\u4e3b\u8981\u7ec8\u70b9Pearl\u6307\u6570\u4e3a2.98\uff0c\u76f4\u63a5\u4f7f\u7528Annovera<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup>\u836f\u7269\u53ef\u4ee5\u8fbe\u523097.3%\u7684\u6709\u6548\u907f\u5b55\u7387<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[8]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u7531\u4e8eAnnovera<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u4f7f\u7528\u65b9\u4fbf\uff0c\u4f5c\u4e3a\u957f\u6548\u836f\u7269\uff0c\u4e0d\u9700\u8981\u590d\u6742\u7684\u5b58\u50a8\u8bbe\u5907\u3002\u5bf9\u4e8e\u4f4e\u8d44\u6e90\u7684\u53d1\u5c55\u4e2d\u56fd\u5bb6\u5973\u6027\u800c\u8a00\uff0c\u662f\u4e00\u79cd\u66f4\u597d\u7684\u907f\u5b55\u66ff\u4ee3\u4ea7\u54c1\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section  label=\"Powered by 135editor.com\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 1.5px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);text-align: justify;\"><span class=\"autonum\"  placeholder=\"1\" style=\"color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);word-wrap: break-word !important;\" title=\"\">3<\/span><span style=\"font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\">Lanadelumab<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"           style=\"width: 206px;height: 139px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537927072.jpeg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">Lanadelumab\u7531Dyax\u516c\u53f8\uff08\u5df2\u88abShire\u6536\u8d2d\uff09\u7814\u53d1\uff0c<\/span><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>\u4e8e2018\u5e748\u670823\u65e5\u83b7FDA\u6279\u51c6\u4e0a\u5e02<\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\uff0c\u7528\u4e8e\u6cbb\u759712\u5c81\u53ca\u4ee5\u4e0a\u7684\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf\uff08HAE\uff09\uff0c\u5546\u54c1\u540d\u4e3a<\/span><strong><span style=\"font-size: 15px;color: rgb(0, 128, 255);\">Takhzyro<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><\/strong><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002\u8be5\u5355\u6297\u836f\u7269\u66fe\u5148\u540e\u88abFDA\uff082013\u5e74\uff09\u3001EMA\uff082015\u5e74\uff09\u8ba4\u8bc1\u4e3a\u6cbb\u7597HAE\u7684\u5b64\u513f\u836f\uff0c\u5e76\u4e8e2015\u5e74\u88abFDA\u8ba4\u8bc1\u4e3a\u6cbb\u7597HAE\u7684\u7a81\u7834\u7597\u6cd5<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[9]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf\uff08HAE\uff09\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u9057\u4f20\u75c5\uff0c<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u5f71\u54cd\u4e16\u754c\u4e0a1\/10000~1\/50000\u7684\u4eba\u3002\u4e34\u5e8a\u8868\u73b0\u4e3a\u53cd\u590d\u53d1\u4f5c\u7684\u8840\u7ba1\u6027\u6c34\u80bf\uff0c\u5e38\u89c1\u4e8e\u8179\u90e8\u3001\u9762\u90e8\u3001\u624b\u3001\u811a\u3001\u751f\u6b96\u7cfb\u7edf\u3001\u5589\u5499\u7b49\u5404\u4e2a\u5668\u5b98\u7ec4\u7ec7\u3002\u5589\u90e8\u53d1\u4f5c\u5f80\u5f80\u4f1a\u963b\u788d\u7a7a\u6c14\u6d41\u901a\uff0c\u589e\u52a0\u4e86\u60a3\u8005\u7684\u7a92\u606f\u98ce\u9669<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[10]<\/span><\/sup>\u3002\u57282009\u5e74\u4ee5\u524d\uff0c\u75c5\u4eba\u53ef\u4ee5\u9009\u62e9\u7684\u6cbb\u7597\u65b9\u6848\u6781\u5176\u6709\u9650\uff0c\u4e25\u91cd\u5f71\u54cd\u4e86\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u3002\u76ee\u524d\u5e38\u89c1\u7684\u836f\u7269\u4e3b\u8981\u662f\u901a\u8fc7\u4e0d\u540c\u7684\u9776\u70b9\u9014\u5f84\uff0c\u964d\u4f4e\u7f13\u6fc0\u80bd\u7684\u4ea7\u751f\u6216\u8005\u6291\u5236\u5176\u751f\u7406\u4f5c\u7528<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[11]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><img class=\"\"       style=\"text-align: center;white-space: normal;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537927072.jpg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u8840\u6d46\u6fc0\u80bd\u91ca\u653e\u9176\u5c06\u9ad8\u5206\u5b50\u91cf\u6fc0\u80bd\u539f\uff08HMWK\uff09\u88c2\u89e3\u5e76\u91ca\u653e\u51fa\u7f13\u6fc0\u80bd\uff0c\u800c\u7f13\u6fc0\u80bd\u4f5c\u4e3a\u8840\u7ba1\u6269\u5f20\u5242\uff0c\u9020\u6210\u8840\u7ba1\u6c34\u80bf\u3002Takhzyro<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u662f\u4e00\u79cd\u9776\u5411\u4e8e\u8840\u6d46\u6fc0\u80bd\u91ca\u653e\u9176\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u4ee5\u6291\u5236\u8be5\u9176\u7684\u86cb\u767d\u6c34\u89e3\u6d3b\u6027<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[12]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">Takhzyro<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup>\u7684\u83b7\u6279\u662f\u57fa\u4e8e\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684\u4e34\u5e8a\u4e09\u671f\u8bd5\u9a8c\uff08NCT02586805\uff09<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\uff0c\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u4e3a\u6c34\u80bf\u53d1\u4f5c\u6b21\u6570\u3002\u6bcf4\u5468\u7ed9\u836f150 mg\u7ec4\u3001\u6bcf4\u5468\u7ed9\u836f300 mg\u7ec4\u3001\u6bcf2\u5468\u7ed9\u836f300 mg\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u53d1\u4f5c\u6b21\u6570\u5206\u522b\u964d\u4f4e\u4e8676%\uff08p\ufe640.01\uff09\u300173%\uff08p\ufe640.01\uff09\u300187%\uff08p\ufe640.01\uff09\u3002\u5728\u4e34\u5e8a\u5b9e\u9a8c\u4e2d\u672a\u51fa\u73b0\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[12]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">Takhzyro<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u4f5c\u4e3a\u9996\u4e2a\u9884\u9632HAE\u53d1\u4f5c\u7684\u5355\u514b\u9686\u6297\u4f53\u836f\u7269\uff0c\u5c06\u4e3aHAE\u60a3\u8005\u63d0\u4f9b\u4e00\u79cd\u4e0d\u540c\u4e8e\u5176\u4ed6\u4e0a\u5e02HAE\u836f\u7269\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u6709\u671b\u6539\u53d8\u8fd9\u4e00\u7f55\u89c1\u75be\u75c5\u7684\u4e34\u5e8a\u6cbb\u7597\u6a21\u5f0f\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section  label=\"Powered by 135editor.com\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 1.5px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);text-align: justify;\"><span class=\"autonum\"  placeholder=\"1\" style=\"color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);word-wrap: break-word !important;\" title=\"\">4<\/span><span style=\"font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\">Eravacycline<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"           style=\"width: 362px;height: 131px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537927073.jpeg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">Eravacycline<\/span><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>\u4e8e2018\u5e748\u670827\u65e5\u83b7\u5f97FDA\u6279\u51c6\uff0c<\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u7528\u4e8e\u6cbb\u759718\u5c81\u4ee5\u4e0a\u7684\u590d\u6742\u8179\u8154\u611f\u67d3\u60a3\u8005\u3002\u8be5\u836f\u7531Tetraphase\u516c\u53f8\u7814\u53d1\u9500\u552e\uff0c\u5546\u54c1\u540d\u4e3a<\/span><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>Xerava<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[13]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u590d\u6742\u8179\u8154\u611f\u67d3\u4e3b\u8981\u5305\u62ec\u9611\u5c3e\u708e\u3001\u80c6\u56ca\u708e\u3001\u61a9\u5ba4\u708e\u3001\u80c3\/\u5341\u4e8c\u6307\u80a0\u7a7f\u5b54\u3001\u8179\u8154\u8113\u80bf\u548c\u8179\u819c\u708e\u7b49\uff0c\u7531\u591a\u79cd\u75c5\u83cc\u611f\u67d3\u5f15\u8d77<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[14<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002\u590d\u6742\u8179\u8154\u611f\u67d3\u901a\u5e38\u8868\u73b0\u4e3a\u7ec4\u7ec7\u521b\u4f24\u6027\u635f\u4f24\uff0c\u5e76\u8bf1\u53d1\u8113\u80bf\u53ca\u8179\u819c\u708e\uff0c\u624b\u672f\u5e72\u9884\u548c\u6297\u751f\u7d20\u836f\u7269\u662f\u5e38\u89c1\u7684\u6cbb\u7597\u63aa\u65bd\u3002\u7136\u800c\uff0c\u6297\u751f\u7d20\u8010\u53d7\u6027\u6b63\u6210\u4e3a\u591a\u75c5\u539f\u5fae\u751f\u7269\u611f\u67d3\u708e\u75c7\u7684\u6cbb\u7597\u6311\u6218\uff0c\u4e5f\u6fc0\u53d1\u4e86\u5f88\u591a\u65b0\u578b\u6297\u751f\u7d20\u836f\u7269\u7684\u5f00\u53d1<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[15]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1537927073.jpg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">Eravacycline\u5c5e\u4e8e\u56db\u73af\u7d20\u7c7b\u6297\u83cc\u836f\u7269\uff0c\u901a\u8fc7\u4e0e\u7ec6\u83cc\u768430S\u6838\u7cd6\u4f53\u4e9a\u57fa\u7ed3\u5408\uff0c\u6291\u5236\u7ec6\u83cc\u591a\u80bd\u94fe\u5ef6\u4f38<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[13, 16]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">Xerava<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup>\u7684\u6279\u51c6\u662f\u57fa\u4e8e\u4e24\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u9633\u6027\u5bf9\u7167\u3001\u56fd\u9645\u591a\u4e2d\u5fc3\u7684\u4e34\u5e8a\u4e09\u671f\u8bd5\u9a8c\uff08NCT01844856\uff0cNCT02784704\uff09\u3002<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u4e34\u5e8a\u6cbb\u6108\u7387\u4ee5\u5b8c\u5168\u6d88\u9000\u6216\u75c7\u72b6\u663e\u8457\u6539\u5584\u4e3a\u6807\u51c6\u3002\u5728\u4e0eErtapenem\u5bf9\u7167\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cXerava<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup>\u6cbb\u7597\u7ec4\u7684\u4e34\u5e8a\u6cbb\u6108\u7387\u4e3a86.8%\uff0cErtapenem\u6cbb\u7597\u7ec4\u4e3a87.6%\uff1b\u5728\u4e0eMeropenem\u5bf9\u7167\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cXerava<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup>\u6cbb\u7597\u7ec4\u7684\u4e34\u5e8a\u6cbb\u6108\u7387\u4e3a90.8%\uff0cMeropenem\u6cbb\u7597\u7ec4\u4e3a91.2%\u3002\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cXerava<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup>\u5747\u663e\u793a\u51fa\u8f83\u597d\u7684\u8010\u53d7\u6027\u548c\u8f83\u9ad8\u7684\u4e34\u5e8a\u6cbb\u6108\u7387\uff0c\u4e0e\u5df2\u4e0a\u5e02\u7684\u9633\u6027\u5bf9\u7167\u7269\u7597\u6548\u76f8\u4f3c<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[16]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u5fae\u751f\u7269\u7684\u6297\u751f\u7d20\u8010\u53d7\u6027\u5df2\u7ecf\u6210\u4e3a\u5168\u7403\u516c\u8ba4\u7684\u536b\u751f\u5a01\u80c1\uff0c\u591a\u836f\u7269\u8010\u53d7\u6027\u708e\u75c7\u4e5f\u5f71\u54cd\u7740\u75c5\u4eba\u5eb7\u590d\u6548\u679c\u3002Xerava\u00ae\u7684\u4e0a\u5e02\u4e3a\u6cbb\u6108\u590d\u6742\u8179\u8154\u611f\u67d3\u63d0\u4f9b\u4e86\u65b0\u7684\u9009\u62e9\u65b9\u6848\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section  label=\"Powered by 135editor.com\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 1.5px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);text-align: justify;\"><span class=\"autonum\"  placeholder=\"1\" style=\"color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);word-wrap: break-word !important;\" title=\"\">5<\/span><span style=\"font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\">Damoctocog alfa pegol<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/0-1537927074.png\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">Damoctocog alfa pegol\u7531\u62dc\u8033\u7814\u53d1\uff0c<\/span><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>\u4e8e2018\u5e748\u670829\u65e5\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c<\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u9002\u7528\u4e8e12\u5c81\u4ee5\u4e0a\u7684\u8840\u53cb\u75c5A\u60a3\u8005\uff0c\u5546\u54c1\u540d\u4e3a<\/span><strong><span style=\"font-size: 15px;color: rgb(0, 128, 255);\">Jivi<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><\/strong><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002\u8be5\u836f\u662f\u4e00\u79cd\u91cd\u7ec4\u4eba\u51dd\u8840\u56e0\u5b50VIII\uff0c\u805a\u4e59\u4e8c\u9187\u5316\u5ef6\u957f\u4e86\u836f\u7269\u7684\u534a\u8870\u671f\u548cAUC<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[17]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">\u8840\u53cb\u75c5\u662f\u4e00\u79cd\u9057\u4f20\u6027\u51dd\u8840\u529f\u80fd\u969c\u788d\u7684\u51fa\u8840\u6027\u75be\u75c5\uff0c<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u5176\u4e2d\u6700\u5e38\u89c1\u7684\u4e3a\u8840\u53cb\u75c5A\uff0c\u7ea6\u5360\u4e34\u5e8a\u768480%\u3002\u8840\u53cb\u75c5\u7684\u4e34\u5e8a\u8868\u73b0\u4e3a\u5916\u90e8\u64e6\u4f24\u800c\u8840\u6d41\u4e0d\u6b62\uff0c\u4ee5\u53ca\u5185\u90e8\u810f\u5668\u3001\u808c\u8089\u3001\u5173\u8282\u7b49\u90e8\u4f4d\u51fa\u8840\u3002\u6b63\u5e38\u7684\u51dd\u8840\u8fc7\u7a0b\u662f\u5728\u4e00\u7cfb\u5217\u51dd\u8840\u56e0\u5b50\u4f5c\u7528\u4e0b\u7684\u7ea7\u8054\u53cd\u5e94\u3002\u51dd\u8840\u56e0\u5b50VIII\u7684\u7f3a\u5931\u6216\u542b\u91cf\u4f4e\u662f\u8840\u53cb\u75c5A\u7684\u81f4\u75c5\u539f\u56e0\u3002\u4e34\u5e8a\u5904\u7406\u8840\u53cb\u75c5\u4e3b\u8981\u662f\u91c7\u53d6\u6ce8\u5c04\u51dd\u8840\u56e0\u5b50\u7684\u66ff\u4ee3\u7597\u6cd5\u3002\u76f8\u6bd4\u4e8e\u8840\u6db2\u63d0\u53d6\u7269\u7684\u611f\u67d3\u98ce\u9669\u3001\u7a7f\u523a\u75bc\u75db\u7b49\uff0c\u57fa\u56e0\u91cd\u7ec4\u836f\u7269\u66f4\u5177\u6709\u4f18\u8d8a\u6027<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[18]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1537927074.jpg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">Jivi<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u901a\u8fc7\u66ff\u4ee3\u7f3a\u5931\u6216\u8005\u542b\u91cf\u4f4e\u7684\u51dd\u8840\u56e0\u5b50VIII\uff0c\u6062\u590d\u8840\u53cb\u75c5\u60a3\u8005\u7684\u51dd\u8840\u529f\u80fd<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[19]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">Jivi<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup>\u7684\u6279\u51c6\u662f\u57fa\u4e8e\u4e00\u9879\u56fd\u9645\u591a\u4e2d\u5fc3\u3001\u516c\u5f00\u6807\u7b7e\u3001\u534a\u968f\u673a\u3001\u975e\u5bf9\u7167\u7684\u4e34\u5e8a\u4e09\u671f\u8bd5\u9a8c\uff08NCT01580293\uff09\u3002<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u672c\u8bd5\u9a8c\u7eb3\u5165132\u4f4d\u75c5\u4eba\uff08\u9884\u9632\u7ed9\u836f\u7ec4112\u4f4d\uff0c\u6309\u9700\u6cbb\u7597\u7ec420\u4f4d\uff09\uff0c\u4e3b\u8981\u7597\u6548\u6307\u6807\u4e3a\u5e74\u51fa\u8840\u7387ABR\u3002\u7ed3\u679c\u663e\u793a\uff0c1~2\u6b21\u6ce8\u5c04\u53ef\u4ee5\u89e3\u51b3\u4e24\u4e2a\u8bd5\u9a8c\u7ec490%\u7684\u51fa\u8840\u4e8b\u4ef6\u3002\u4e0e\u6309\u9700\u6cbb\u7597\u7ec4\u76f8\u6bd4\uff0c\u6bcf5\u5929\u6ce8\u5c04\u4e00\u6b21\u53ef\u4ee5\u51cf\u5c1188.2%\u7684\u51fa\u8840\u4e8b\u4ef6\uff08p\ufe640.001\uff09<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[19, 20]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">Jivi<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u662f\u62dc\u8033\u516c\u53f8\u63a8\u51fa\u7684\u7b2c\u4e09\u4e2a\u91cd\u7ec4\u51dd\u8840\u56e0\u5b50\uff0c\u76f8\u6bd4\u4e8e\u524d\u4e24\u4ee3\u4ea7\u54c1\uff08Kogenate FS\u548cKovaltry\uff09\uff0cJivi<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u5177\u6709\u5206\u5b50\u91cf\u5c0f\u3001\u836f\u6548\u6301\u4e45\u3001\u53ef\u4e2a\u6027\u5316\u7528\u836f\u7b49\u7279\u70b9\uff0c\u6781\u5927\u5730\u65b9\u4fbf\u4e86\u533b\u751f\u548c\u75c5\u4eba\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section  label=\"Powered by 135editor.com\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 1.5px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);text-align: justify;\"><span class=\"autonum\"  placeholder=\"1\" style=\"color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);word-wrap: break-word !important;\" title=\"\">6<\/span><span style=\"font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\">Doravirine<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537927074.png\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">Doravirine\u7531\u9ed8\u6c99\u4e1c\u7814\u53d1\uff0c<\/span><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>\u4e8e2018\u5e748\u670830\u65e5\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c<\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u5546\u54c1\u540d\u4e3a<\/span><strong><span style=\"font-size: 15px;color: rgb(0, 128, 255);\">Pifeltro<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><\/strong><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002Doravirine\u662f\u4e00\u79cd\u975e\u6838\u82f7\u9006\u8f6c\u5f55\u9176\u6291\u5236\u5242\uff08NNRTI\uff09\uff0c\u53ef\u4ee5\u4e0e\u6838\u82f7\u7c7b\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u836f\u7269\uff08NRTI\uff09\u8054\u5408\u4f7f\u7528\uff0c\u6cbb\u7597\u4ece\u672a\u63a5\u53d7\u8fc7\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u836f\u7269\u6cbb\u7597\uff08ART\uff09\u7684\u6210\u5e74\u578bHIV-1\u611f\u67d3<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[21]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">HIV\u611f\u67d3\u53ca\u827e\u6ecb\u75c5\u662f\u4e16\u754c\u6027\u7684\u516c\u5171\u536b\u751f\u96be\u9898\uff0c\u5728\u4e2d\u4f4e\u6536\u5165\u56fd\u5bb6\u5c24\u5176\u5982\u6b64\u3002\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u7597\u6cd5\uff08ART\uff09\u53ef\u4ee5\u6709\u6548\u5730\u9632\u6b62\u75c5\u6bd2\u589e\u6b96\uff0c\u8ba9\u611f\u67d3\u8005\u50cf\u666e\u901a\u4eba\u4e00\u6837\u751f\u6d3b\u3002\u6839\u636e\u4e16\u536b\u7ec4\u7ec7\u7edf\u8ba1\uff0c\u5168\u74033690\u4e07\u540dHIV\u643a\u5e26\u8005\u4e2d\uff0c\u53ea\u670959%\u7684\u611f\u67d3\u8005\u8fdb\u884c\u4e86\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u6cbb\u7597\u3002HIV\u75c5\u6bd2\u4fb5\u88adCD4+ T\u7ec6\u80de\uff0c\u9020\u6210\u514d\u75ab\u7cfb\u7edf\u6e10\u8fdb\u6027\u8870\u9000<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[22]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537927075.jpg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u4f5c\u4e3a\u975e\u6838\u82f7\u9006\u8f6c\u5f55\u9176\u6291\u5236\u5242\uff08NNRTI\uff09\uff0cDoravirine\u901a\u8fc7\u975e\u7ade\u4e89\u6027\u7ed3\u5408HIV-1\u9006\u8f6c\u5f55\u9176\u963b\u6b62\u75c5\u6bd2\u590d\u5236<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[23]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">Pifeltro<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup>\u7684\u6279\u51c6\u662f\u57fa\u4e8e\u4e24\u9879\u968f\u673a\u3001\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u9633\u6027\u5bf9\u7167\u7684\u4e34\u5e8a\u4e09\u671f\u8bd5\uff08NCT02275780\uff0cNCT02403674\uff09\u3002<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u5728\u7b2c\u4e00\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cPifeltro<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup>\u8054\u54082\u79cdNRTI\u836f\u7269\u4e0e\u9633\u6027\u5bf9\u7167\u7ec4\u7684CD4+T\u7ec6\u80de\u5206\u522b\u6062\u590d\u5230193\u4e2a\/mm3\u3001186\u4e2a\/ mm3\u3002\u5728\u7b2c\u4e8c\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cPifeltro<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup>\u8054\u54082\u79cdNRTI\u836f\u7269\u4e0e\u9633\u6027\u5bf9\u7167\u7ec4\u7684CD4+T\u7ec6\u80de\u5206\u522b\u6062\u590d\u5230198\u4e2a\/mm3\u3001188\u4e2a\/ mm3\u3002\u4e24\u9879\u8bd5\u9a8c\u5747\u5f97\u5230\u4e86\u4e0d\u52a3\u4e8e\u9633\u6027\u5bf9\u7167\u7ec4\u7684\u7597\u6548\u7ed3\u679c\uff0c\u5b9e\u73b0\u4e86\u5bf9\u75c5\u6bd2\u7684\u6709\u6548\u63a7\u5236<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[23]<\/span><\/sup>\u3002\u57fa\u4e8e\u7b2c\u4e8c\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0cFDA\u540c\u671f\u6279\u51c6\u4e86\u542b\u6709Doravirine\/ Lamivudine\/ Tenofovir Disoproxil Fumarate\u7684\u590d\u65b9\u836f\u7269Delstrigo<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae[24]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">Doravirine\u662f\u65b0\u4e00\u4ee3\u7684NNRTI\u4ea7\u54c1\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597HIV-1\u611f\u67d3\u8005\u3002Pifeltro<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u548cDelstrigo<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u7684\u83b7\u6279\u4e3a\u827e\u6ecb\u75c5\u7684\u4e34\u5e8a\u6cbb\u7597\u63d0\u4f9b\u4e86\u66f4\u591a\u7684\u9009\u62e9\u65b9\u5f0f\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><br  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section  label=\"Powered by 135editor.com\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 1.5px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);text-align: justify;\"><span class=\"autonum\"  placeholder=\"1\" style=\"color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);word-wrap: break-word !important;\" title=\"\">7<\/span><span style=\"font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\">Pyrotinib Maleate<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"width: 279px;height: 140px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1537927075.png\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">Pyrotinib Maleate\uff08\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\u7247\uff09<\/span><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>\u4e8e2018\u5e748\u670812\u65e5\u83b7NMPA\uff08\u539fCFDA\uff09\u6279\u51c6\u4e0a\u5e02\uff0c<\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u7528\u4e8e\u6cbb\u7597HER2\u9633\u6027\u665a\u671f\u4e73\u817a\u764c<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[25]<\/span><\/sup>\u3002\u8be5\u836f\u662f\u4e2d\u56fd\u9996\u4e2a\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684HER2\u9776\u5411\u836f\u7269\uff0c\u7531\u6c5f\u82cf\u6052\u745e\u7814\u53d1\u9500\u552e\uff0c\u5546\u54c1\u540d\u4e3a<\/span><strong><span style=\"font-size: 15px;color: rgb(0, 128, 255);\">\u827e\u745e\u59ae<sup><span style=\"font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><\/strong><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002\u8be5\u836f\u7684\u4e34\u5e8a\u7533\u62a5\u6309\u7167\u7279\u6b8a\u5ba1\u6279\u5904\u7406<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[26]<\/span><\/sup>\uff0c\u5e76\u57fa\u4e8e\u4e34\u5e8a\u4e8c\u671f\u8bd5\u9a8c\u7684\u663e\u8457\u7597\u6548\u83b7\u5f97NMPA\u6709\u6761\u4ef6\u6279\u51c6<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[27, 28]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u4e73\u817a\u764c\u662f\u5973\u6027\u6700\u5e38\u89c1\u7684\u80bf\u7624\u75be\u75c5\uff0c\u5168\u7403\u6bcf\u5e74\u7ea6150\u4e07\u4f4d\u5973\u6027\u88ab\u8bca\u65ad\u51fa\u4e73\u817a\u764c\u30022015\u5e74\uff0c\u5168\u4e16\u754c\u7ea657\u4e07\u5973\u6027\u6b7b\u4e8e\u4e73\u817a\u764c\uff0c\u5360\u5973\u6027\u764c\u75c7\u6b7b\u4ea1\u768415%\u3002\u5c3d\u7ba1\u4e73\u817a\u764c\u66f4\u5e38\u89c1\u4e8e\u53d1\u8fbe\u56fd\u5bb6\uff0c\u4f46\u662f\u5728\u5176\u4ed6\u5730\u533a\u6b63\u5448\u73b0\u51fa\u9010\u5e74\u589e\u9ad8\u7684\u60c5\u51b5<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[29]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002\u800c\u6839\u636e\u300a2015\u4e2d\u56fd\u764c\u75c7\u7edf\u8ba1\u6570\u636e\u300b\uff0c\u4e73\u817a\u764c\u5df2\u7ecf\u6210\u4e3a\u6211\u56fd\u5973\u6027\u53d1\u75c5\u7387\u6700\u9ad8\u7684\u6076\u6027\u80bf\u7624\uff0c\u7ea6\u5360\u6240\u6709\u5973\u6027\u764c\u75c7\u603b\u53d1\u75c5\u7387\u768416.5%<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[27]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002\u5176\u4e2d\uff0cHER2\u8fc7\u8868\u8fbe\u662f\u5e38\u89c1\u7684\u4e73\u817a\u764c\u8bf1\u53d1\u56e0\u7d20\u4e4b\u4e00\uff0c\u5360\u4e73\u817a\u764c\u768415~20%<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[30]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537927075-1.jpg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\uff08Pyrotinib Maleate\uff09\u662f\u4e00\u79cd\u975e\u53ef\u9006\u7684\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\u6291\u5236\u5242\uff0c\u901a\u8fc7\u5c06\u53d7\u4f53\u7684\u80de\u5185\u533aATP\u9176\u7ed3\u5408\u57df\u7684\u534a\u80f1\u6c28\u9178\u6b8b\u57fa\u70f7\u57fa\u5316\uff0c\u4f7f\u53d7\u4f53\u6c38\u4e45\u5931\u6d3b\u3002\u5421\u54af\u66ff\u5c3c\u5bf9ERBB\u5bb6\u65cf\u7684HER1\u3001HER2\u3001HER4\u5177\u6709\u5e7f\u8c31\u6027\u7684\u6291\u5236\u4f5c\u7528<\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[31, 32]<\/span><\/sup><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\u7531\u4e8e\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u7a81\u7834\u6027\u7597\u6548\u800c\u88abNMPA\u5217\u5165\u4f18\u5148\u5ba1\u8bc4\uff08NCT02422199\uff0cCTR20150279\uff09\u3002<\/span><\/strong><\/span><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u76f8\u5173\u7ed3\u679c\u663e\u793a\uff1a\u5728\u9488\u5bf9\u7ecf\u84bd\u73af\u7c7b\u548c\u7d2b\u6749\u9187\u7c7b\u836f\u7269\u6cbb\u7597\u5931\u8d25\uff0c\u4e14\u590d\u53d1\u3001\u8f6c\u79fb\u540e\u5316\u7597\u4e0d\u8d85\u8fc72\u7ebf\u7684\u4e73\u817a\u764c\u60a3\u8005\uff0c\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\u7247\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u7247\uff08ORR\u4e3a78.5%\uff0cmPFS\u4e3a18.1\u4e2a\u6708\uff09\uff0c\u4e0e\u7532\u82ef\u78fa\u9178\u62c9\u5e15\u66ff\u5c3c\u7247\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u7247\uff08ORR\u4e3a57.1%\uff0cmPFS\u4e3a7.0\u4e2a\u6708\uff09\u76f8\u6bd4\uff0c\u60a3\u8005\u7684\u751f\u5b58\u671f\u663e\u8457\u5ef6\u957f\uff0c\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u610f\u4e49\uff08p&lt;0.0001\uff09\uff0c\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u4e0b\u964d63.7%\uff08HR=0.363\uff09\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d<sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[32]<\/span><\/sup>\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\uff08Pyrotinib Maleate\uff09\u7684\u4e0a\u5e02\uff0c\u4e3aHER2\u9633\u6027\u4e73\u817a\u764c\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u6cbb\u7597\u624b\u6bb5\u3002<\/span><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>\u4f5c\u4e3aNMPA\u7684\u4f18\u5148\u8bc4\u5ba1\u4ea7\u54c1\uff0c\u4ece\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\u5230\u83b7\u6279\u4ec5\u7528\u4e8610\u4e2a\u6708\u3002\u8be5\u56fd\u4ea7\u836f\u7269\u7684\u8fc5\u901f\u83b7\u6279\uff0c\u5c06\u6781\u5927\u5730\u6fc0\u53d1\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u7684\u521b\u65b0\u6d3b\u529b\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(0, 0, 0);font-size: 15px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">\u53c2\u8003\u6587\u732e<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">1.&nbsp;\u836f\u6e21\u6570\u636e\uff1ahttps:\/\/data.pharmacodia.com\/web\/basic\/basic_detail_PN15410.html(accessed August 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">2. Gertz, M.A., Hereditary ATTR amyloidosis:burden of illness and diagnostic challenges. Am J Manag Care, 2017. 23(7Suppl): p. S107-s112.<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">3. Drugbank. https:\/\/www.drugbank.ca\/drugs\/DB14582&nbsp; (accessedAugust 2018) <\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">4. FDA Database. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/210922s000lbl.pdf (accessedAugust 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">5.&nbsp;\u836f\u6e21\u6570\u636e\uff1ahttps:\/\/data.pharmacodia.com\/web\/basic\/basic_detail_PC901.html(accessed August 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">6. Population Council\u5b98\u7f51: https:\/\/www.popcouncil.org\/news\/fda-approves-the-first-one-year-contraceptive-fully-under-a-womans-control&nbsp; (accessed August 2018)<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">7. Drugbank https:\/\/www.drugbank.ca\/drugs\/DB14583&nbsp; (accessedAugust 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">8. FDA Database. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/209627s000lbl.pdf&nbsp; (accessed August 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">9.&nbsp;\u836f\u6e21\u6570\u636e\uff1ahttps:\/\/data.pharmacodia.com\/web\/basic\/basic_detail_PB0286.html&nbsp; (accessed August 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">10.Shire\u5b98\u7f51\uff1ahttps:\/\/www.shire.com\/en\/newsroom\/2018\/august\/4fhgmy&nbsp; (accessed August 2018) <\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">11.Gower, R.G., et al., Currentoptions for prophylactic treatment of hereditary angioedema in the UnitedStates: patient-based considerations. Allergy Asthma Proc, 2012. 33(3): p.235-40.<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">12.FDA Database. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/761090s000lbl.pdf&nbsp; (accessed August 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">13.\u836f\u6e21\u6570\u636e\uff1ahttps:\/\/data.pharmacodia.com\/web\/basic\/basic_detail_PN0863.html(accessed August 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">14.Tetraphase \u5b98\u7f51\uff1ahttps:\/\/ir.tphase.com\/news-releases\/news-release-details\/tetraphase-pharmaceuticals-announces-fda-approval-xeravatm&nbsp; (accessed August 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">15.Solomkin, J., et al.,Ceftolozane\/Tazobactam Plus Metronidazole for Complicated Intra-abdominalInfections in an Era of Multidrug Resistance: Results From a Randomized,Double-Blind, Phase 3 Trial (ASPECT-cIAI). Clin Infect Dis, 2015. 60(10): p.1462-71.<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">16.FDA Database. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/211109lbl.pdf&nbsp; (accessed August 2018) <\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">17.\u836f\u6e21\u6570\u636e\uff1ahttps:\/\/data.pharmacodia.com\/web\/basic\/basic_detail_PB0191.html(accessed August 2018) <\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">18.\u62dc\u8033\u5b98\u7f51\uff1ahttp:\/\/pharma.bayer.com\/en\/treatment-care\/heart-and-blood-disorders\/hemophilia\/ (accessedAugust 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">19.FDA Database. https:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/UCM618979.pdf (accessedAugust 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">20.Reding, M.T., et al., Safety andefficacy of BAY 94-9027, a prolonged-half-life factor VIII. J Thromb Haemost,2017. 15(3): p. 411-419.<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">21.\u836f\u6e21\u6570\u636e\uff1ahttps:\/\/data.pharmacodia.com\/web\/basic\/basic_detail_PN0872.html&nbsp; (accessed August 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">22.WHO\u5b98\u7f51\uff1ahttp:\/\/www.who.int\/news-room\/facts-in-pictures\/detail\/hiv-aids&nbsp;&nbsp; (accessed August 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">23.FDA Database. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/210806s000lbl.pdf&nbsp; (accessed August 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">24.FDA Database. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/210807s000lbl.pdf (accessedAugust 2018)<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">25.\u836f\u6e21\u6570\u636e\uff1ahttps:\/\/data.pharmacodia.com\/web\/basic\/basic_detail_PN2476.html(accessed August 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">26.\u54b8\u8fbe\u6570\u636e : http:\/\/www.xanda.cn\/blog\/?p=10167&nbsp; (accessed July 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">27.\u6c5f\u82cf\u6052\u745e\u5b98\u7f51\uff1ahttp:\/\/www.hrs.com.cn\/main_newshow\/show-6018.html&nbsp; (accessed August 2018) <\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">28.\u96ea\u7403\uff1ahttps:\/\/xueqiu.com\/S\/SH600276\/112284539&nbsp; (accessed July 2018) <\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">29.WHO\u5b98\u7f51\uff1ahttp:\/\/www.who.int\/cancer\/prevention\/diagnosis-screening\/breast-cancer\/en\/&nbsp;&nbsp; (accessed August 2018).<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">30.Krishnamurti, U. and J.F.Silverman, HER2 in breast cancer: a review and update. Adv Anat Pathol, 2014.21(2): p. 100-7.<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">31.\u6768\u660c\u6c38,\u66f9\u56fd\u5e86,\u5510\u871c,\u5b59\u661f,\u5b59\u626c\u98de,\u5f20\u8fde\u5c71, \u4e00\u79cdEGFR\/HER2\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u5728\u5236\u5907\u6cbb\u7597\u764c\u75c7\u7684\u836f\u7269\u4e2d\u7684\u7528\u9014.201710588783 .3. 2017.<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\">32.B Xu, F.M., Q Ouyang, W Li, ZJiang, Z Tong, Y Liu, H Li, S Yu, J Feng, S Wang, X Hu, X Zhu and J Zou, Arandomized phase II trial of pyrotinib plus capecitabine versus lapatinib pluscapecitabine in patients with HER2-positive metastatic breast cancer previouslytreated with taxanes, anthracyclines and\/or trastuzumab, in 2017 San AntonioBreast Cancer Symposium., in 2017 San Antonio Breast Cancer Symposium. 2018.02.<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 10px;\"><br  \/><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section  label=\"Powered by 135editor.com\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section style=\"text-align:center;\">\n<section  style=\"display: inline-block;background-color: #ffffff;\">\n<section style=\"padding-top: 8px;padding-right: 8px;background-image: repeating-linear-gradient(-45deg, transparent, transparent 1px, rgb(254, 254, 254) 4px, rgb(254, 254, 254) 8px);box-sizing: border-box;\">\n<section style=\"padding: 6px 20px;background-color: rgb(182, 228, 253);box-sizing: border-box;\">\n<p><strong>\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"padding: 40px 20px 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src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1537927078.jpg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"         style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537927079.jpg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"         style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537927080.jpg\" alt=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e748\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<section class=\"RankEditor\" style=\"margin-top: 20px;\">\n<section style=\"display: inline-block;vertical-align: middle;width:12%;box-sizing: border-box;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"display:inline-block;width: 88%;padding:5px;box-sizing: border-box;vertical-align:middle;\">\n<p class=\"active brush\" style=\"box-sizing: border-box;font-size: 16px;color: rgb(121,121,121);min-width:1px;\"><span style=\"font-size: 15px;\">\u7acb\u5373\u89e3\u9501\u4f60\u7684\u638c\u4e0a\u4e13\u4e1a\u5de5\u5177\uff01<\/span><\/p>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>2018\u5e748\u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40FDA\u5171\u6279\u51c65\u4e2a\u65b0\u5206\u5b50\u5b9e\u4f53\u836f\u7269\uff08NME\uff09\uff0c\u5206\u522b\u662f\u6cbb\u7597\u8f6c\u7532\u72b6\u817a\u7d20\u86cb\u767d\u5bb6\u65cf\u6027 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