{"id":49456,"date":"2018-09-19T01:00:00","date_gmt":"2018-09-26T01:58:34","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e3%80%90%e6%81%92%e7%91%9epd-1%e6%8b%9b%e5%8b%9f24%e3%80%91shr-1210%e8%81%94%e5%90%88bp102%e5%9c%a8egfr-alk%e9%87%8e%e7%94%9f%e5%9e%8b%e9%9d%9e%e5%b0%8f%e7%bb%86%e8%83%9e%e8%82%ba%e7%99%8c%e5%88%9d\/"},"modified":"2018-09-26T09:58:35","modified_gmt":"2018-09-26T01:58:35","slug":"%e3%80%90%e6%81%92%e7%91%9epd-1%e6%8b%9b%e5%8b%9f24%e3%80%91shr-1210%e8%81%94%e5%90%88bp102%e5%9c%a8egfr-alk%e9%87%8e%e7%94%9f%e5%9e%8b%e9%9d%9e%e5%b0%8f%e7%bb%86%e8%83%9e%e8%82%ba%e7%99%8c%e5%88%9d","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/49456\/","title":{"rendered":"\u3010\u6052\u745ePD-1\u62db\u52df24\u3011SHR-1210\u8054\u5408BP102\u5728EGFR\/ALK\u91ce\u751f\u578b\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u521d\u6cbb\u60a3\u8005\u5355\u81c2\u3001\u5f00\u653e\u3001\u591a\u4e2d\u5fc3II\u671f\u7814\u7a76"},"content":{"rendered":"
\n
<\/mpcps><\/section>\n

<\/span>
<\/p>\n

1.  <\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span><\/p>\n

\u6297<\/span>PD-1<\/span>\u6297\u4f53<\/span>(programmed death 1)<\/span>\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53<\/span>1<\/span>\uff0c\u662f\u4e00\u79cd\u91cd\u8981\u7684\u514d\u75ab\u6291\u5236\u5206\u5b50\u3002\u672c\u8bd5\u9a8c\u836f\u7269\u662f\u6052\u745e\u7814\u53d1\u7684<\/span>SHR-1210<\/span>\u3002<\/span><\/span><\/p>\n

BP102<\/span>\u662f\u6052\u745e\u7814\u53d1\u7684\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u3002<\/span><\/span><\/p>\n

\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f<\/span>PD-L1<\/span>\u9633\u6027\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027<\/span>EGFR\/ALK<\/span>\u91ce\u751f\u578b\u975e\u9cde\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

2.      <\/span><\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n

\u8bc4\u4ef7<\/span>SHR-1210<\/span>\u8054\u5408<\/span>BP102<\/span>\u5728<\/span>PD-L1<\/span>\u9633\u6027\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027<\/span>EGFR\/ALK<\/span>\u91ce\u751f\u578b\u975e\u9cde\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u521d\u6cbb\u60a3\u8005\u4e2d\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08<\/span>ORR<\/span>\uff09\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08<\/span>PFS<\/span>\uff09\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

3.       <\/span><\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u5206\u7c7b\uff1a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u5206\u671f\uff1a<\/span> II<\/span>\u671f<\/span><\/span><\/p>\n

\u8bbe\u8ba1\u7c7b\u578b\uff1a\u5355\u81c2\u8bd5\u9a8c<\/span><\/span><\/p>\n

\u968f\u673a\u5316\uff1a<\/span>     <\/span>\u975e\u968f\u673a\u5316<\/span><\/p>\n

\u76f2\u6cd5\uff1a<\/span>         <\/span>\u5f00\u653e<\/span><\/p>\n

\u8bd5\u9a8c\u8303\u56f4\uff1a <\/span>\u56fd\u5185\u8bd5\u9a8c<\/span><\/p>\n

\u8bd5\u9a8c\u4eba\u6570\uff1a<\/span> 50<\/span><\/span>\u4eba<\/span><\/p>\n


<\/p>\n


<\/span><\/span><\/p>\n

4.       <\/span><\/span>\u5165\u9009\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff08<\/span>ICF<\/span>\uff09\uff1b<\/span><\/span><\/p>\n

2  18-75<\/span>\u5c81\uff08\u542b\u4e24\u7aef\u503c\uff09\uff0c\u7537\u5973\u4e0d\u9650\uff1b<\/span><\/span><\/p>\n

3  ECOG PS 0~1<\/span>\uff1b<\/span><\/span><\/p>\n

4  <\/span>\u53c2\u7167<\/span>RECIST v1.1<\/span>\u6807\u6ce8\uff0c\u81f3\u5c11\u6709\u4e00\u4e2a\u672a\u7ecf\u653e\u7597\u7684\u53ef\u6d4b\u91cf\u7684\u75c5\u7076\uff1b<\/span><\/span><\/p>\n

5  <\/span>\u7ec4\u7ec7\u5b66\u6216\u7ec6\u80de\u5b66\u786e\u8bca\u4e3a<\/span>EGFR\/ALK<\/span>\u91ce\u751f\u578b\u7684\u975e\u9cde\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u5e76\u4e14\u4e3a<\/span>IIIB~IV<\/span>\u671f\u80bf\u7624\u7684\u53d7\u8bd5\u8005\uff1b<\/span><\/span><\/p>\n

6  <\/span>\u5145\u5206\u7684\u8840\u6db2\u5b66\u6216\u7ec8\u672b\u5668\u5b98\u529f\u80fd<\/span><\/span><\/p>\n

7  <\/span>\u613f\u610f\u53c2\u52a0\u80fd\u591f\u9075\u5b88\u7814\u7a76\u65b9\u6848\u8981\u6c42\uff0c\u5e76\u613f\u610f\u914d\u5408\u968f\u8bbf\u3002<\/span><\/span><\/p>\n

8  <\/span>\u975e\u624b\u672f\u7edd\u80b2\u7684\u80b2\u9f84\u671f\u5973\u6027\u6216\u7537\u6027\u53d7\u8bd5\u8005\uff0c\u9700\u540c\u610f\u5728\u7814\u7a76\u6cbb\u7597\u671f\u95f4\u548c\u7814\u7a76\u6cbb\u7597\u671f\u7ed3\u675f\u540e<\/span>6<\/span>\u4e2a\u6708\u5185\u91c7\u7528\u4e00\u79cd\u7ecf\u533b\u5b66\u8ba4\u53ef\u7684\u907f\u5b55\u63aa\u65bd\uff08\u5982\u5bab\u5185\u8282\u80b2\u5668\uff0c\u907f\u5b55\u836f\u6216\u907f\u5b55\u5957\uff09\u8fdb\u884c\u907f\u5b55\uff1b\u975e\u624b\u672f\u7edd\u80b2\u7684\u80b2\u9f84\u671f\u5973\u6027\u53d7\u8bd5\u8005\u5728\u9996\u6b21\u7ed9\u836f\u524d\u7684<\/span>7<\/span>\u5929\u5185\u8840\u6e05\u4eba\u7ed2\u6bdb\u819c\u4fc3\u6027\u817a\u6fc0\u7d20\uff08<\/span>HCG<\/span>\uff09\u68c0\u67e5\u5fc5\u987b\u4e3a\u9634\u6027\uff0c\u4e14\u5fc5\u987b\u4e3a\u975e\u54fa\u4e73\u671f\uff1b<\/span><\/span><\/p>\n

 <\/span><\/p>\n

5.       <\/span><\/span>\u6392\u9664\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u6392\u9664\u5176\u4ed6\u75c5\u7406\u7ec4\u7ec7\u7c7b\u578b\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53d7\u8bd5\u8005\uff0c\u5305\u62ec\u9cde\u72b6\u7ec6\u80de\u764c\uff0c\u6216\u4ee5\u9cde\u764c\u4e3a\u4e3b\u7684\u80ba\u817a\u9cde\u764c\uff0c\u6216\u975e\u5c0f\u7ec6\u80de\u548c\u5c0f\u7ec6\u80de\u6df7\u5408\u578b<\/span>NSCLC<\/span>\uff1b<\/span><\/span><\/p>\n

2  <\/span>\u672a\u7ecf\u624b\u672f\u548c<\/span>\/<\/span>\u6216\u653e\u7597\u7684\u810a\u9ad3\u538b\u8feb\uff0c\u6216\u5148\u524d\u8bca\u65ad\u7684\u810a\u9ad3\u538b\u8feb\u4e14\u7ecf\u8fc7\u6cbb\u7597\uff0c\u5728\u9996\u5242\u7814\u7a76\u836f\u7269\u7ed9\u836f\u524d\u65e0\u8bc1\u636e\u8868\u660e\u7a33\u5b9a<\/span>> 2<\/span>\u5468\uff1b<\/span><\/span><\/p>\n

3  <\/span>\u6709\u5148\u5929\u6027\u7684\u80ba\u7ea4\u7ef4\u5316\u3001\u8fc1\u5ef6\u6027\u80ba\u708e\u3001\u836f\u7269\u5f15\u8d77\u7684\u80ba\u708e\u3001\u5148\u5929\u6027\u80ba\u708e\u75c5\u53f2\u6216\u80f8\u90e8<\/span>CT<\/span>\u626b\u63cf\u53d1\u73b0\u4efb\u4f55\u6d3b\u52a8\u6027\u80ba\u708e\u8bc1\u636e\uff1b<\/span><\/span><\/p>\n

4  <\/span>\u4e0d\u80fd\u63a7\u5236\u7684\u80bf\u7624\u76f8\u5173\u75bc\u75db<\/span><\/span><\/p>\n

5  <\/span>\u5df2\u77e5\u9ad8\u8840\u538b\u5371\u8c61\u6216\u9ad8\u8840\u538b\u8111\u75c5\uff1b<\/span><\/span><\/p>\n

6  <\/span>\u51dd\u8840\u529f\u80fd\u5f02\u5e38\uff0c\u5177\u6709\u51fa\u8840\u503e\u5411\u6216\u6b63\u5728\u63a5\u53d7\u6eb6\u6813\u6216\u6297\u51dd\u6cbb\u7597\uff1b<\/span><\/span><\/p>\n

 <\/span><\/p>\n

6.       <\/span><\/span>\u533b\u9662\u548c\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n

\u4e3b\u8981\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/p>\n\n\n\n\n\n
\n

\u59d3\u540d <\/span><\/p>\n<\/td>\n

\n

\u8303\u4e91\uff0c\u533b\u5b66\u535a\u58eb <\/span><\/p>\n<\/td>\n

\n

\u804c\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u4efb\u533b\u5e08 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u90ae\u653f\u5730\u5740 <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f\u7701\u676d\u5dde\u5e02\u62f1\u5885\u533a\u534a\u5c71\u4e1c\u8def1\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u90ae\u7f16 <\/span><\/p>\n<\/td>\n

\n

310022 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5355\u4f4d\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5404\u53c2\u52a0\u673a\u6784\u4fe1\u606f<\/span><\/p>\n\n\n\n\n
\n

\u5e8f\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u673a\u6784\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u7814\u7a76\u8005 <\/span><\/p>\n<\/td>\n

\n

\u56fd\u5bb6 <\/span><\/p>\n<\/td>\n

\n

\u7701\uff08\u5dde\uff09 <\/span><\/p>\n<\/td>\n

\n

\u57ce\u5e02 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1 <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u738b\u51ef <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f <\/span><\/p>\n<\/td>\n

\n

\u676d\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n

\u672c\u8bd5\u9a8c\u4fe1\u606f\u6765\u81ea<\/span>CFDA<\/span>\u201c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u516c\u793a\u5e73\u53f0\u201d\u3002<\/span><\/span><\/p>\n

\u6b22\u8fce\u7533\u529e\u65b9\/CRO\/\u533b\u9662\u63d0\u4f9b\u80bf\u7624\u62db\u52df\u4fe1\u606f\uff0c\u53ef\u4ee5\u53d1\u90ae\u4ef6\u81f3LCSYZMXX@163.com\uff0c\u672c\u516c\u4f17\u53f7\u9996\u6b21\u514d\u8d39\u63a8\u9001\uff0c\u5176\u4ed6\u5546\u4e1a\u5408\u4f5c\u4e5f\u53ef\u4ee5\u53d1\u6b64\u90ae\u7bb1\uff01<\/span><\/p>\n


<\/p>\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

1.  \u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb \u6297PD-1\u6297\u4f53(programmed death 1)\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f531\uff0c\u662f\u4e00\u79cd […]<\/p>\n","protected":false},"author":1,"featured_media":49457,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49456"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=49456"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49456\/revisions"}],"predecessor-version":[{"id":49458,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49456\/revisions\/49458"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/49457"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=49456"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=49456"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=49456"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}