{"id":49484,"date":"2018-09-20T01:00:00","date_gmt":"2018-09-26T01:58:58","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e6%b2%bb%e5%84%bf%e7%ab%a5%e8%a1%80%e7%99%8c-yes-%e6%88%90%e4%ba%bano%ef%bc%9a%e8%8b%b1%e5%9b%bdnice%e9%ab%98%e8%b0%83%e6%8b%92car-t\/"},"modified":"2018-09-26T09:58:59","modified_gmt":"2018-09-26T01:58:59","slug":"%e6%b2%bb%e5%84%bf%e7%ab%a5%e8%a1%80%e7%99%8c-yes-%e6%88%90%e4%ba%bano%ef%bc%9a%e8%8b%b1%e5%9b%bdnice%e9%ab%98%e8%b0%83%e6%8b%92car-t","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/49484\/","title":{"rendered":"\u6cbb\u513f\u7ae5\u8840\u764c Yes \u6210\u4ebaNO\uff1a\u82f1\u56fdNICE\u9ad8\u8c03\u62d2CAR-T"},"content":{"rendered":"
\n

\u201c\u5f88\u96be\u786e\u5b9a Kymriah(tisagenlecleucel )\u7684\u786e\u5207\u597d\u5904, \u201c \u82f1\u56fd\u59d4\u5458\u4f1a\u5728\u7ed3\u8bba\u4e2d\u8868\u793a\u3002<\/span><\/p>\n


<\/p>\n

\u201c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b, tisagenlecleucel \u5728\u764c\u75c7\u836f\u7269\u57fa\u91d1 (CDF) \u5185\u7684\u5e38\u89c4\u8d44\u91d1\uff08\u8986\u76d6\uff09\u548c\u4f7f\u7528\u65b9\u9762\u5e76\u4e0d\u5177\u6709\u6210\u672c\u6548\u76ca\u3002\u201c\u82f1\u56fd\u7684NICE\u5728\u58f0\u660e\u4e2d\u8868\u793a\u3002<\/span><\/p>\n


<\/p>\n

NICE\u662f\u56fd\u5bb6\u4e34\u5e8a\u5353\u8d8a\u4e2d\u5fc3(National Instituet for Health and Clinical Excellence)\u7684\u7b80\u79f0\uff0c\u8fd9\u4e2a\u673a\u6784\u8d1f\u8d23\u51b3\u5b9a\u54ea\u4e9b\u836f\u7269\u53ef\u4ee5\u8fdb\u5165\u56fd\u5bb6\u5065\u5eb7\u670d\u52a1\uff08NHS\uff09\u7684\u8986\u76d6\u3002<\/span><\/p>\n

\"\u6cbb\u513f\u7ae5\u8840\u764c<\/p>\n

\u7136\u800c, NICE\u4e5f\u540c\u65f6\u627f\u8ba4, \u8bfa\u534e\u7684\u8fd9\u4e2a\u5d4c\u5408\u539f\u6297\u4f53T\u7ec6\u80de\u7597\u6cd5\u5177\u6709\u663e\u8457\u7684\u4e34\u5e8a\u6548\u76ca, \u5e76\u5e0c\u671b\u80fd\u8fdb\u4e00\u6b65\u8ba8\u8bba\u5176\u6210\u672c\u6548\u76ca\u3002<\/span><\/p>\n


<\/p>\n

NICE\u7684\u72ec\u7acb\u6280\u672f\u8bc4\u4f30\u59d4\u5458\u4f1a\u662f\u5728\u8bc4\u5ba1\u4e86 Kymriah\u4e8c\u7ebf\u6216\u4e09\u7ebf\u6cbb\u7597\u6210\u4eba\u590d\u53d1\u6216\u987d\u56fa\u578b\u5f25\u6f2b\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u540e\u505a\u51fa\u4e0a\u8ff0\u51b3\u5b9a\u7684\u3002<\/span><\/p>\n


<\/p>\n

\u8bfa\u534e\u516c\u53f8\u627f\u8bfa\uff0c\u5728282,000\u82f1\u9551\u7684\u5b9a\u4ef7\u4e0a\u7ed9NICE\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6ca1\u6709\u900f\u9732\u8be6\u60c5\u7684\u6298\u6263<\/span>\u3002<\/span><\/p>\n


<\/p>\n

\u4f46\u662f, \u6210\u672c\u6548\u76ca\u4ecd\u7136\u9ad8\u4e8eNICE\u8ba4\u4e3a\u53ef\u4ee5\u63a5\u53d7\u7684\u8303\u56f4\u3002<\/span><\/p>\n


<\/p>\n

\u59d4\u5458\u4f1a\u5c06\u572810\u670823\u65e5\u7684\u4e0b\u4e00\u6b21\u4f1a\u8bae\u4e0a\u7ee7\u7eed\u8bc4\u5ba1\u3002<\/span><\/p>\n


<\/p>\n

\u672c\u6708\u65e9\u4e9b\u65f6\u5019\uff0cNICE\u652f\u6301\u80bf\u7624\u57fa\u91d1\u4e3aKymriah\u63d0\u4f9b\u8d44\u91d1\uff0c\u7528\u4e8e\u6cbb\u759725\u5c81\u4ee5\u4e0b\u60a3\u6709\u6025\u6027B\u7ec6\u80de\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08ALL\uff09<\/span>, \u96be\u4ee5\u6cbb\u6108\uff0c\u79fb\u690d\u540e\u590d\u53d1\u6216\u5728\u6570\u5468\u5185\u590d\u53d1\u6216\u7b2c\u4e8c\u6b21\u6216\u665a\u671f\u590d\u53d1\u7684\u60a3\u8005\u3002<\/span><\/p>\n


<\/p>\n

CAR-T\u6cbb\u7597\u5f00\u521b\u4e86\u4e2a\u6027\u5316\u6cbb\u7597\u80bf\u7624\u7684\u65b0\u65f6\u4ee3\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u4e2a\u7597\u6cd5\u4e3a\u6bcf\u4e2a\u75c5\u4eba\u4e2a\u6027\u5316\u8bbe\u8ba1\uff0c\u5176\u4e2d\u5305\u62ec\u5bf9\u60a3\u8005\u7684\u767d\u8840\u7403\u8fdb\u884c\u57fa\u56e0\u6539\u9020, \u4ee5\u4fbf\u4ed6\u4eec\u80fd\u591f\u8bc6\u522b\u548c\u653b\u51fb\u764c\u7ec6\u80de\u3002<\/span><\/p>\n


<\/p>\n

\u5c3d\u7ba1\u5bf9\u60a3\u6709\u6dcb\u5df4\u7624\u7684\u6210\u4eba\u6709\u663e\u8457\u7684\u4e34\u5e8a\u7597\u6548, \u4f46\u6ca1\u6709\u6570\u636e\u6bd4\u8f83 tisagenlecleucel \u4e0e\u62a2\u6551\uff08salvage\uff09\u5316\u7597, \u8fd9\u662f\u76ee\u524d\u7528\u4e8e\u8fd9\u7c7b\u8840\u6db2\u80bf\u7624\u7684\u6700\u5e38\u89c1\u7684\u6cbb\u7597\u65b9\u6cd5, NICE\u8868\u793a\u3002<\/span><\/p>\n


<\/p>\n

\u800c\u4e14\uff0c CAR-T\u8fd8\u6709\u8bb8\u591a\u526f\u4f5c\u7528, <\/span>\u9700\u8981\u8bad\u7ec3\u6709\u7d20\u7684\u4e13\u5bb6\u8fdb\u884c\u76d1\u6d4b\u4e5f\u662f\u5341\u5206\u5fc5\u8981<\/span>\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u867d\u7136\u76ee\u524d\u65e0\u6cd5\u63a8\u8350\u8fd9\u4e2a\u6cbb\u7597, \u4f46NICE\u8fd8\u662f\u5e0c\u671b\u8fdb\u4e00\u6b65\u8ba8\u8bbaKymriah \u6cbb\u7597\u6210\u4ebaB \u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u3002<\/span><\/p>\n


<\/p>\n

NICE\u5065\u5eb7\u6280\u672f\u8bc4\u4f30\u4e2d\u5fc3\u4e3b\u4efb Meindert Boysen \u8bf4: “\u6211\u4eec\u5728\u65e9\u671f\u8bd5\u9a8c\u4e2d\u770b\u5230\u4e86\u5bf9CAR-T\u7597\u6cd5\u7684\u6709\u5e0c\u671b\u7684\u7ed3\u679c, \u5e76\u8ba4\u4e3a tisagenlecleucel \u6709\u5f88\u5927\u7684\u6f5c\u529b\uff0c\u80fd\u5e2e\u52a9\u90a3\u4e9b\u6ca1\u6709\u56de\u5e94\u5176\u4ed6\u5f62\u5f0f\u7684\u6cbb\u7597\u3002\u201c<\/span><\/p>\n


<\/p>\n

“\u867d\u7136\u6211\u4eec\u4e0d\u80fd\u5efa\u8bae\u6210\u4eba\u4f7f\u7528 tisagenlecleucel \u6dcb\u5df4\u7624, \u4f46\u6211\u4eec\u6b22\u8fce\u56f4\u7ed5\u6cbb\u7597\u548c\u4e0e\u5229\u76ca\u6538\u5173\u8005\u63a5\u89e6\u7684\u6210\u672c\u6548\u76ca\u95ee\u9898\u8fdb\u884c\u8fdb\u4e00\u6b65\u8ba8\u8bba.”<\/span><\/p>\n


<\/p>\n

\u6dcb\u5df4\u7624\u662f\u6dcb\u5df4\u7cfb\u7edf\u7684\u764c\u75c7\u30022015\u5e74, \u82f1\u56fd\u6709\u5927\u7ea611,690\u4f8b\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624 (NHL)\u60a3\u8005, \u5176\u4e2d4\uff0c688\u4e3a\u5f25\u6f2b\u6027\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u3002<\/span><\/p>\n


<\/span><\/p>\n

NICE\u58f0\u660e<\/span><\/strong>\uff1a<\/span><\/p>\n

https:\/\/www.nice.org.uk\/news\/article\/nice-encourages-further-discussions-on-kymriah-for-adult-lymphoma<\/p>\n

<\/span>
<\/p>\n

\u4f60\u53ef\u80fd\u559c\u6b22<\/strong>\uff1a<\/p>\n

\u5f81\u670d\u8840\u6db2\u80bf\u7624\uff0c\u534e\u4eba\u5973\u533b\u751f\u5317\u5927\u8bb2\u8ff0CAR-T\u68a6<\/a>
<\/p>\n

\u65bd\u8d35\u5b9d\u98ce\u5934\u6b63\u5065Opdivo\u88ab\u82f1\u56fdNICE\u62d2\u7edd|\u5065\u70b9\u5b50\u56fd\u9645\u836f\u8baf<\/a>
<\/p>\n

\u4e2d\u56fd\u5236\u9020\u80bf\u7624\u65b0\u836f\u83b7\u6279 \u548c\u8bb0\u9ec4\u57d4\u7b2c\u4e00<\/a>
<\/p>\n


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\u670d\u52a1\u65b0\u836f\u7814\u53d1 \u628a\u63e1\u6295\u8d44\u8d8b\u52bf<\/span><\/em><\/span><\/p>\n

\u6bcf\u5929\u7528\u65b0\u8bf4\u8bdd \u51b3\u7b56\u4e0d\u53ef\u6216\u7f3a<\/span><\/em><\/span><\/p>\n

\u5065\u70b9\u5b50ihealth<\/em><\/strong>\u662f\u533b\u836f\u884c\u4e1a\u9886\u5148\u7684\u6295\u8d44\u987e\u95ee\u8d44\u8baf\u5e73\u53f0\uff0c\u4e13\u6ce8<\/em>\u7f55\u89c1\u75c5\uff0c<\/strong>\u751f\u7269\u7c7b\u4f3c\u836f\uff0c<\/strong><\/em>\u65e5\u97e9\u5370\u5ea6<\/strong><\/em>\u5065\u5eb7\u884c\u4e1a\u7684\u6700\u65b0\u52a8\u5411\u3002<\/em><\/span><\/p>\n

\u4f60\u4e5f\u53ef\u4ee5\u5728\u4efb\u4f55\u5065\u70b9\u5b50\u6587\u7ae0\u540e\u7559\u8a00\u3002\u8bf7\u7b80\u77ed\u8bf4\u660e\u5177\u4f53\u9700\u6c42\u3002\u6211\u4eec\u4e00\u822c\u572824\u5c0f\u65f6\u4e4b\u5185\u8054\u7cfb\u3002<\/em><\/span><\/p>\n

<\/em><\/em><\/em><\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u201c\u5f88\u96be\u786e\u5b9a Kymriah(tisagenlecleucel )\u7684\u786e\u5207\u597d\u5904, \u201c \u82f1\u56fd\u59d4\u5458\u4f1a\u5728\u7ed3\u8bba\u4e2d\u8868\u793a\u3002 \u201c […]<\/p>\n","protected":false},"author":1,"featured_media":49485,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49484"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=49484"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49484\/revisions"}],"predecessor-version":[{"id":49487,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/49484\/revisions\/49487"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/49485"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=49484"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=49484"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=49484"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}