{"id":50002,"date":"2018-09-21T01:00:00","date_gmt":"2018-09-26T02:04:13","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e5%8f%8d%e6%80%9d%ef%bc%81%e7%a7%91%e5%ad%a6%e7%a0%94%e7%a9%b6%e4%b8%ba%e5%95%a5%e5%af%b990%e7%9a%84%e5%9f%ba%e5%9b%a0%e8%a7%86%e8%80%8c%e4%b8%8d%e8%a7%81%ef%bc%9f\/"},"modified":"2018-09-26T10:04:16","modified_gmt":"2018-09-26T02:04:16","slug":"%e5%8f%8d%e6%80%9d%ef%bc%81%e7%a7%91%e5%ad%a6%e7%a0%94%e7%a9%b6%e4%b8%ba%e5%95%a5%e5%af%b990%e7%9a%84%e5%9f%ba%e5%9b%a0%e8%a7%86%e8%80%8c%e4%b8%8d%e8%a7%81%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/50002\/","title":{"rendered":"\u53cd\u601d\uff01\u79d1\u5b66\u7814\u7a76\u4e3a\u5565\u5bf990%\u7684\u57fa\u56e0\u89c6\u800c\u4e0d\u89c1\uff1f"},"content":{"rendered":"
\n

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\u30101\u3011\u5783\u573eDNA\u662f\u8bf1\u53d1\u764c\u75c7\u7684\u52a8\u529b<\/p>\n

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\u795e\u7ecf\u5b66\u6559\u6388\u73cd\u59ae\u00b7\u52b3\u4f26\u65af\uff08Jeanne Lawrence\uff09\u535a\u58eb\u8bf4\uff1a\u201c\u8fd9\u4e9b\u536b\u661f\u91cd\u590d\u50cf\u901a\u5e38\u63a7\u5236\u5176\u4ed6\u57fa\u56e0\u8868\u8fbe\u7684\u4e3b\u8981\u8c03\u8282\u56e0\u5b50\u7684\u5206\u5b50\u6d77\u7ef5\u201d\u3002<\/p>\n

\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u7684\u4e00\u4e2a\u5de8\u5927\u7684\u7a7a\u767d\u6846\u5c1a\u672a\u88ab\u5b8c\u5168\u6d4b\u5e8f\u548c\u5b9a\u4f4d\uff0cHSAT-II\u7531\u6570\u767e\u4e07\u4efd\u975e\u5e38\u4e30\u5bcc\u7684\u5c0f\u5e8f\u5217\u7ec4\u6210\uff0c\u53ef\u4ee5\u5728\u663e\u5fae\u955c\u4e0b\u89c2\u5bdf\u5230\u4e00\u4e9b\u67d3\u8272\u4f53\uff0c\u7279\u522b\u662f\u67d3\u8272\u4f531\u3002\u56e0\u4e3aHSAT-II DNA\u901a\u5e38\u662f\u7532\u57fa\u5316\u7684\uff08\u4e00\u79cd\u5f62\u5f0f\u7684\u57fa\u56e0\u8c03\u63a7\uff09\uff0c\u5b83\u5728\u5065\u5eb7\u7ec6\u80de\u4e2d\u4fdd\u6301\u4f11\u7720\u3002\u56e0\u6b64\uff0cHSAT-II\u5c1a\u672a\u5f97\u5230\u5e7f\u6cdb\u7684\u7814\u7a76\u3002\u4e8b\u5b9e\u4e0a\uff0c\u6807\u51c6\u7684\u57fa\u56e0\u7ec4\u5b9e\u9a8c\u6709\u610f\u7684\u5c4f\u853d\u4e86HSAT-II\u7684\u7ed3\u679c\u3002<\/p>\n

\"\u53cd\u601d\uff01\u79d1\u5b66\u7814\u7a76\u4e3a\u5565\u5bf990%\u7684\u57fa\u56e0\u89c6\u800c\u4e0d\u89c1\uff1f\"<\/p>\n

\u30102\u3011Science\uff1a\u201c\u5783\u573eDNA\u201d\u4e2d\u53d1\u73b0\u6f5c\u5728\u764c\u75c7\u75c5\u6e90<\/p>\n

DOI\uff1a10.1126\/science.1235587<\/strong><\/p>\n

\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u4ec5\u67091%\u52302%\u7684\u662f\u8d1f\u8d23\u86cb\u767d\u8d28\u7f16\u7801\u7684\u57fa\u56e0\uff0c\u5176\u4f59\u975e\u7f16\u7801\u533a\u57df\u65e9\u5148\u88ab\u8ba4\u4e3a\u662f\u6beb\u65e0\u7528\u5904\u7684\u201c\u5783\u573eDNA\u201d\u3002\u4f46\u662f\uff0c\u7f8e\u3001\u82f1\u7b49\u56fd\u7814\u7a76\u4eba\u5458\u6700\u8fd1\u5728\u8fd9\u4e2a\u201c\u5783\u573e\u201d\u533a\u57df\u4e2d\u627e\u5230\u8fd1\u767e\u4e2a\u4e73\u817a\u764c\u4e0e\u524d\u5217\u817a\u764c\u7684\u6f5c\u5728\u201c\u5bfc\u706b\u7d22\u201d\uff0c\u663e\u793a\u4e86\u7814\u7a76\u201c\u5783\u573eDNA\u201d\u5bf9\u4e86\u89e3\u764c\u75c7\u7684\u91cd\u8981\u6027\u3002<\/p>\n

\u7f8e\u56fd\u8036\u9c81\u5927\u5b66\u3001\u82f1\u56fd\u97e6\u5c14\u79d1\u59c6\u57fa\u91d1\u4f1a\u6851\u683c\u7814\u7a76\u6240\u7b49\u673a\u6784\u7684\u7814\u7a76\u4eba\u545810\u67083\u65e5\u5728\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u4e0a\u62a5\u544a\u8bf4\uff0c\u968f\u7740\u4e2a\u4eba\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u7684\u6210\u672c\u76f4\u7ebf\u4e0b\u964d\uff0c\u8fdb\u884c\u6d4b\u5e8f\u7684\u4eba\u6570\u8fc5\u901f\u589e\u52a0\uff0c\u89e3\u8bfb\u4ed6\u4eec\u57fa\u56e0\u7ec4\u4e2d\u7684\u7a81\u53d8\u3001\u5c24\u5176\u662f\u975e\u7f16\u7801\u533a\u7684\u7a81\u53d8\uff0c\u5df2\u6210\u4e3a\u5f53\u524d\u533b\u5b66\u754c\u9762\u4e34\u7684\u6311\u6218\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u5229\u7528\u5927\u578b\u56fd\u9645\u79d1\u7814\u5408\u4f5c\u9879\u76ee\u201c\u5343\u4eba\u57fa\u56e0\u7ec4\u9879\u76ee\u201d\u83b7\u5f97\u7684\u57fa\u56e0\u53d8\u5f02\u6570\u636e\uff0c\u7ed3\u5408\u53e6\u4e00\u4e2a\u56fd\u9645\u5408\u4f5c\u9879\u76ee\u201cDNA\u5143\u7d20\u767e\u79d1\u5168\u4e66\uff08ENCODE\uff09\u201d\u7684\u4fe1\u606f\uff0c\u5f00\u53d1\u51fa\u4e00\u79cd\u65b0\u65b9\u6cd5\uff0c\u5728\u201c\u5783\u573eDNA\u201d\u4e2d\u7b5b\u9009\u53ef\u80fd\u5bfc\u81f4\u764c\u75c7\u7684\u7a81\u53d8\uff0c\u4e5f\u5c31\u662f\u764c\u75c7\u7684\u6f5c\u5728\u201c\u5bfc\u706b\u7d22\u201d\u3002<\/p>\n

\u30103\u3011Science\uff1a\u201c\u5783\u573eDNA\u201d\u51b3\u5b9a\u4eba\u8138\u957f\u76f8<\/p>\n

DOI\uff1a10.1126\/science.1241006<\/strong><\/p>\n

\u6709\u7684\u4eba\u76f8\u8c8c\u5802\u5802\uff0c\u6709\u7684\u4eba\u770b\u4e0a\u53bb\u4e0d\u5c3d\u5982\u4eba\u610f\u3002\u7f8e\u56fd\u7814\u7a76\u4eba\u5458\u7684\u6700\u65b0\u7814\u7a76\u8868\u660e\uff0c\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u7684\u201c\u5783\u573eDNA\u201d\uff0c\u53ef\u80fd\u662f\u6bcf\u4e2a\u4eba\u90fd\u957f\u5f97\u4e0e\u4f17\u4e0d\u540c\u7684\u6700\u7ec8\u51b3\u5b9a\u56e0\u7d20\u3002<\/p>\n

\u6240\u8c13\u201c\u5783\u573eDNA\u201d\uff0c\u662f\u6307\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u66fe\u88ab\u8ba4\u4e3a\u6beb\u65e0\u7528\u5904\u7684\u90e8\u5206\uff0c\u5b83\u4eec\u5728\u57fa\u56e0\u7ec4\u4e2d\u6240\u5360\u6bd4\u4f8b\u9ad8\u8fbe98%\u3002\u4f46\u7f8e\u56fd\u4f2f\u514b\u5229\u52b3\u4f26\u65af\u56fd\u5bb6\u5b9e\u9a8c\u6240\u7684\u7814\u7a76\u4eba\u545810\u670824\u65e5\u5728\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u4e0a\u62a5\u544a\u8bf4\uff0c\u4ed6\u4eec\u53d1\u73b0\u201c\u5783\u573eDNA\u201d\u4e2d\u6709\u4e00\u4e9b\u5e8f\u5217\u7247\u6bb5\uff0c\u53ef\u4ee5\u50cf\u5f00\u5173\u6216\u653e\u5927\u5668\u4e00\u6837\u5f71\u54cd\u8138\u90e8\u57fa\u56e0\u7684\u4f5c\u7528\u3002\u773c\u775b\u7684\u5927\u5c0f\u3001\u9f3b\u5b50\u7684\u633a\u62d4\u3001\u5934\u9885\u7684\u5f62\u72b6\u7b49\u53ef\u80fd\u90fd\u4e0e\u8fd9\u4e9b\u88ab\u79f0\u4e3a\u201c\u589e\u5f3a\u5b50\u201d\u7684\u5e8f\u5217\u7247\u6bb5\u5bc6\u4e0d\u53ef\u5206\u3002<\/p>\n

\u7814\u7a76\u8d1f\u8d23\u4eba\u3001\u9057\u4f20\u5b66\u5bb6\u963f\u514b\u585e\u5c14\u00b7\u83f2\u6cfd\u5c14\u5728\u4e00\u4efd\u58f0\u660e\u4e2d\u8bf4\uff1a\u201c\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u53ef\u80fd\u6709\u6210\u5343\u4e0a\u4e07\u4e2a\u589e\u5f3a\u5b50\uff0c\u5b83\u4eec\u90fd\u5728\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u5f71\u54cd\u8138\u578b\u7684\u5f62\u6210\uff0c\u4f46\u6211\u4eec\u5c1a\u4e0d\u6e05\u695a\u8fd9\u4e9b\u589e\u5f3a\u5b50\u90fd\u5728\u600e\u6837\u53d1\u6325\u4f5c\u7528\u3002\u201d<\/p>\n

\"\u53cd\u601d\uff01\u79d1\u5b66\u7814\u7a76\u4e3a\u5565\u5bf990%\u7684\u57fa\u56e0\u89c6\u800c\u4e0d\u89c1\uff1f\"<\/p>\n

\u30104\u3011Nat Struct Mol Biol \uff1a”\u5783\u573eDNA”\u7684\u7247\u6bb5\u4fe1\u606f\u6216\u53ef\u6539\u53d8\u57fa\u56e0\u7ec4\u88c5\u65b9\u5f0f<\/p>\n

doi\uff1a10.1038\/nsmb.2459<\/strong><\/p>\n

\u6765\u81ea\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u5728\u4e00\u9879\u65b0\u7814\u7a76\u4e2d\u9610\u660e\u4e86\u6211\u4eec\u7684\u6bcf\u4e2a\u57fa\u56e0\u4e2d\uff0c\u6240\u8c13\u7684\u201c\u5783\u573e\u201dDNA\uff08\u53c8\u79f0\u6697\u7269\u8d28\uff09\u6267\u884c\u7684\u4e00\u79cd\u91cd\u8981\u7684\u8c03\u63a7\u529f\u80fd\u3002\u65b0\u7814\u7a76\u63ed\u793a\uff1a\u5305\u542b\u5728\u6697\u7269\u8d28\u4e2d\u7684\u7247\u6bb5\u4fe1\u606f\u6709\u53ef\u80fd\u6539\u53d8\u4e86\u57fa\u56e0\u7684\u7ec4\u88c5\u65b9\u5f0f\u3002<\/p>\n

\u7814\u7a76\u7684\u8d44\u6df1\u4f5c\u8005\u3001\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u533b\u5b66\u9662\u836f\u7406\u5b66\u52a9\u7406\u6559\u6388\u3001Lineberger\u7efc\u5408\u764c\u75c7\u4e2d\u5fc3\u6210\u5458\u738b\u6cfd\u5cf0\uff08Zefeng Wang\uff0c\u97f3\u8bd1\uff09\u535a\u58eb\u8bf4\uff1a\u201c\u8fd9\u4e9b\u5c0f\u7684\u9057\u4f20\u4fe1\u606f\u5e8f\u5217\u544a\u8bc9\u57fa\u56e0\u5982\u4f55\u526a\u63a5\uff0c\u6216\u662f\u63d0\u9ad8\u6216\u662f\u6291\u5236\u526a\u63a5\u8fc7\u7a0b\u3002\u672c\u7814\u7a76\u4e3a\u89e3\u6790\u57fa\u56e0\u6697\u7269\u8d28\u5f00\u542f\u4e86\u5927\u95e8\u3002\u5b83\u6709\u52a9\u4e8e\u6211\u4eec\u66f4\u6df1\u5165\u5730\u4e86\u89e3\u7a81\u53d8\u6216\u591a\u6001\u6027\u5f71\u54cd\u57fa\u56e0\u529f\u80fd\u7684\u673a\u5236\u3002\u201d<\/p>\n

\u8fd9\u4e00\u7814\u7a76\u53d1\u5e03\u57282013\u5e741\u6708\u7684\u300a\u81ea\u7136\u7ed3\u6784\u4e0e\u5206\u5b50\u751f\u7269\u5b66\u300b\uff08Nature Structural & Molecular Biology\uff09\u6742\u5fd7\u4e0a\u3002<\/p>\n

\u526a\u63a5\u7684\u8fc7\u7a0b\uff0c\u6216\u8bb8\u53ef\u4e0e\u7535\u5f71\u884c\u4e1a\u7684\u526a\u7247\u8fc7\u7a0b\u76f8\u6bd4\uff0c\u4e00\u4e9b\u7535\u5f71\u80f6\u7247\u7247\u6bb5\u88ab\u62fc\u63a5\u5230\u4e00\u8d77\uff0c\u53e6\u5916\u4e00\u4e9b\u5219\u6700\u7ec8\u88ab\u5f03\u4e4b\u5728\u526a\u8f91\u5ba4\u7684\u5730\u677f\u4e0a\u3002<\/p>\n

\u30105\u3011Cell Rep\uff1a\u91cd\u78c5\u7ea7\u53d1\u73b0\uff01\u79d1\u5b66\u5bb6\u9610\u660e\u201c\u5783\u573eDNA\u201d\u5728\u764c\u75c7\u53d1\u751f\u8fc7\u7a0b\u626e\u6f14\u7684\u5173\u952e\u89d2\u8272<\/p>\n

DOI\uff1a10.1016\/j.celrep.2017.02.072<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Cell Reports\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u9a6c\u8428\u8bf8\u585e\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u8868\u793a\uff0c\u4eba\u7c7b\u536b\u661fII\uff08Human satellite II\uff0cHSAT-II\uff09\u662f\u4e00\u79cd\u9ad8\u5ea6\u62f7\u8d1d\u4f46\u76ee\u524d\u5c1a\u672a\u8fdb\u884c\u63a2\u7d22\u7814\u7a76\u7684\u4eba\u7c7b\u57fa\u56e0\u7ec4\u5e8f\u5217\uff0c\u5176\u4e5f\u88ab\u8ba4\u4e3a\u662f\u5783\u573eDNA\uff08junk DNA\uff09\uff0c\u4f46\u4eba\u7c7b\u536b\u661fII\u5e8f\u5217\u80fd\u591f\u5f71\u54cd\u6211\u4eec\u57fa\u56e0\u7ec4\u4e2d\u7684\u4e3b\u8981\u8c03\u8282\u5143\u4ef6\uff0c\u800c\u4e14\u5176\u5728\u5927\u7ea650%\u7684\u80bf\u7624\u4e2d\u90fd\u5904\u4e8e\u201c\u9519\u8bef\u201d\u72b6\u6001\u3002\u5f53\u8be5\u5e8f\u5217\u88ab\u89e3\u9664\u8c03\u8282\u540e\uff0c\u5927\u91cf\u7684\u91cd\u590d\u6027\u6838\u82f7\u9178\u5e8f\u5217\u5c31\u4f1a\u88ab\u5efa\u7acb\uff0c\u800c\u4e14\u764c\u7ec6\u80de\u4e2d\u4e3b\u8981\u7684\u8c03\u8282\u6027\u86cb\u767d\u4f1a\u88ab\u6324\u5165\u5230\u6838\u5c0f\u4f53\u4e2d\uff0c\u8fd9\u5f88\u6709\u53ef\u80fd\u4f1a\u5f15\u53d1\u8868\u89c2\u9057\u4f20\u4e0d\u7a33\u5b9a\u6027\uff0c\u4ece\u800c\u5c31\u4f1a\u9a71\u52a8\u591a\u79cd\u764c\u75c7\u7684\u53d1\u751f\u3002<\/p>\n

\u7814\u7a76\u8005Jeanne Lawrence\u8868\u793a\uff0c\u8fd9\u4e9b\u536b\u661f\u91cd\u590d\u5e8f\u5217\u5c31\u597d\u50cf\u662f\u4e3b\u8981\u8c03\u8282\u56e0\u5b50\u7684\u5206\u5b50\u6d77\u7ef5\u4e00\u6837\uff0c\u5176\u80fd\u591f\u63a7\u5236\u5176\u5b83\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u968f\u7740\u65f6\u95f4\u6d41\u901d\uff0c\u5f53\u7ec6\u80de\u8870\u8001\u4ee5\u53ca\u5206\u88c2\u65f6\uff0c\u8fd9\u4e9b\u6539\u53d8\u5c31\u4f1a\u9020\u6210\u9057\u4f20\u4e0d\u7a33\u5b9a\u6027\u7684\u4ea7\u751f\uff0c\u8fdb\u800c\u5c31\u4f1a\u5bfc\u81f4\u7279\u6b8a\u7684\u764c\u75c7\u76f8\u5173\u57fa\u56e0\u53d8\u5f97\u5177\u6709\u6d3b\u6027\u3002\u76ee\u524d\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8fd9\u4e00\u5de8\u5927\u7684\u7a7a\u767d\u7bb1\u8fd8\u6ca1\u6709\u88ab\u5b8c\u5168\u8fdb\u884c\u6d4b\u5e8f\u548c\u7ed8\u56fe\uff0cHSAT-II\u5305\u542b\u4e86\u6570\u767e\u4e07\u4e2a\u975e\u5e38\u4e30\u5bcc\u7684\u5c0f\u578b\u5e8f\u5217\u62f7\u8d1d\uff0c\u800c\u4e14\u5176\u663e\u5fae\u955c\u4e0b\u5c31\u80fd\u591f\u89c2\u5bdf\u5230\u67d0\u4e9b\u67d3\u8272\u4f53\uff0c\u5c24\u5176\u662f1\u53f7\u67d3\u8272\u4f53\uff0c\u7531\u4e8eHSAT-II\u7684DNA\u5728\u6b63\u5e38\u60c5\u51b5\u4e0b\u5904\u4e8e\u7532\u57fa\u5316\u72b6\u6001\uff0c\u56e0\u6b64\u5728\u5065\u5eb7\u7ec6\u80de\u4e2d\u5176\u4f9d\u7136\u5904\u4e8e\u4f11\u7720\u72b6\u6001\uff0c\u57fa\u4e8e\u8fd9\u4e2a\u539f\u56e0\uff0c\u7814\u7a76\u4eba\u5458\u65e0\u6cd5\u5bf9HSAT-II\u8fdb\u884c\u5e7f\u6cdb\u7684\u7814\u7a76\uff0c\u800c\u4e14\u7814\u7a76\u4eba\u5458\u4e5f\u8ba4\u4e3a\u8be5\u5e8f\u5217\u5e76\u4e0d\u4f1a\u53d1\u6325\u4f5c\u7528\uff0c\u5b9e\u9645\u4e0a\uff0c\u6807\u51c6\u7684\u57fa\u56e0\u7ec4\u5b66\u5b9e\u9a8c\u4f1a\u6709\u610f\u8bc6\u5730\u5254\u9664\u6389HSAT-II\u7684\u7ed3\u679c\u3002<\/p>\n

\"\u53cd\u601d\uff01\u79d1\u5b66\u7814\u7a76\u4e3a\u5565\u5bf990%\u7684\u57fa\u56e0\u89c6\u800c\u4e0d\u89c1\uff1f\"<\/p>\n

\u30106\u3011Cell\uff1a\u5783\u573eRNA\u5728\u7ec6\u80de\u5e94\u6fc0\u53cd\u5e94\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528<\/p>\n

doi\uff1a10.1016\/j.cell.2016.11.041<\/strong><\/p>\n

\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u9ebb\u7701\u603b\u533b\u9662\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u4e4b\u524d\u88ab\u8ba4\u4e3a\u662f\u975e\u529f\u80fd\u6027\u7684\u201c\u5783\u573e\u201dRNA\u5206\u5b50\u7684\u4e00\u79cd\u610f\u60f3\u4e0d\u5230\u7684\u4f5c\u7528\uff1a\u63a7\u5236\u7ec6\u80de\u5bf9\u5e94\u6fc0\u4f5c\u51fa\u7684\u53cd\u5e94\u3002\u4ed6\u4eec\u63cf\u8ff0\u4e86\u4e4b\u524d\u5df2\u77e5\u6291\u5236\u57fa\u56e0\u8f6c\u5f55\u7684\u4e24\u4e2a\u7ec4\u5206—B2 RNA\u548c\u4f5c\u4e3a\u4e00\u79cd\u4e4b\u524d\u5df2\u77e5\u4ec5\u6c89\u9ed8\u57fa\u56e0\u7684\u9176\uff0cEZH2—\u4e4b\u95f4\u7684\u4e00\u79cd\u9ad8\u5ea6\u7279\u5f02\u6027\u7684\u76f8\u4e92\u4f5c\u7528\u5b9e\u9645\u4e0a\u8bf1\u5bfc\u5c0f\u9f20\u7ec6\u80de\u5e94\u6fc0\u53cd\u5e94\u57fa\u56e0\u8868\u8fbe\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u57282016\u5e7412\u670815\u65e5\u90a3\u671fCell\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cDestabilization of B2 RNA by EZH2 Activates the Stress Response\u201d\u3002<\/p>\n

\u8bba\u6587\u901a\u4fe1\u4f5c\u8005\u3001\u9ebb\u7701\u603b\u533b\u9662\u5206\u5b50\u751f\u7269\u5b66\u7cfbJeannie T. Lee\u535a\u58eb\u8bf4\uff0c\u201cEZH2\u662f\u4e00\u79cd\u88ab\u79f0\u4f5c\u591a\u68b3\u6291\u5236\u590d\u5408\u72692\uff08Polycomb Repressive Complex 2\uff0c PRC2\uff09\u7684\u7ed3\u6784\u7684\u4e00\u90e8\u5206\uff0c\u5176\u4e2dPRC2\u6c89\u9ed8\u9776\u57fa\u56e0\u3002\u4f46\u662f\u8fd9\u4e2a\u9886\u57df\u5b58\u5728\u7684\u4e00\u4e2a\u5927\u7684\u6096\u8bba\u662fEZH2\u5728\u6709\u6d3b\u6027\u7684\u57fa\u56e0\u548c\u6ca1\u6709\u6d3b\u6027\u7684\u57fa\u56e0\u4e2d\u90fd\u53ef\u53d1\u73b0\u5230\u3002\u6211\u4eec\u9996\u6b21\u8bc1\u5b9eEZH2\u80fd\u591f\u5728PRC2\u590d\u5408\u7269\u5916\u9762\u53d1\u6325\u4f5c\u7528\uff1a\u901a\u8fc7\u53e6\u4e00\u79cd\u673a\u5236\u6fc0\u6d3b\u57fa\u56e0—\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\u662f\u901a\u8fc7\u5207\u5272B2 RNA\u6765\u5b9e\u73b0\u7684\uff0c\u8fd9\u79cd\u5207\u5272\u968f\u540e\u6fc0\u6d3b\u5e94\u6fc0\u53cd\u5e94\u57fa\u56e0\u3002\u201d<\/p>\n

\u30107\u3011Nat Commun\uff1a\u201c\u5783\u573e\u201dDNA\u663e\u795e\u6548\u2014\u2014\u6cbb\u7597\u4e73\u817a\u764c<\/p>\n

doi\uff1a10.1038\/ncomms10406<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u53d1\u8868\u5728\u56fd\u9645\u6742\u5fd7Nature Communications\u4e0a\u7684\u4e00\u9879\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u5df4\u65af\u5927\u5b66\u548c\u5251\u6865\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c\u4f4d\u4e8e\u57fa\u56e0\u95f4\u7684\u5783\u573eDNA\u6d3b\u5728\u6291\u5236\u764c\u75c7\u53d1\u751f\u4e0a\u626e\u6f14\u7740\u91cd\u8981\u89d2\u8272\uff1b\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u5305\u542b\u6709\u5927\u7ea63\u7c73\u957f\u7684DNA\uff0c\u8fd9\u5176\u4e2d\u5927\u7ea6\u67092%\u7684\u57fa\u56e0\u884c\u9a76\u7740\u7f16\u7801\u86cb\u767d\u7684\u4f5c\u7528\uff0c2000\u5e74\u4eba\u7c7b\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u5b8c\u6210\u540e\uff0c\u79d1\u5b66\u5bb6\u4eec\u5c31\u5bf9\u90a3\u5269\u4f59\u768498%\u7684DNA\u4ea7\u751f\u4e86\u7279\u522b\u6d53\u539a\u7684\u5174\u8da3\u3002<\/p>\n

\u8fd1\u4e9b\u5e74\u6765\u7814\u7a76\u8005\u53d1\u73b0\uff0c\u8bb8\u591a\u975e\u7f16\u7801DNA\u5b9e\u9645\u4e0a\u90fd\u53ef\u4ee5\u8f6c\u5f55\u6210\u4e3a\u975e\u7f16\u7801\u7684RNA\uff0c\u7136\u800c\u975e\u7f16\u7801\u7684RNA\u5230\u5e95\u5728\u7ec6\u80de\u4e2d\u6709\u6ca1\u6709\u529f\u80fd\u76ee\u524d\u79d1\u5b66\u754c\u5b58\u5728\u4e0d\u540c\u7684\u770b\u6cd5\uff0c\u5176\u4e2d\u4e00\u90e8\u5206\u539f\u56e0\u5c31\u662f\u76ee\u524d\u7814\u7a76\u4eba\u5458\u5f88\u96be\u5728\u4e0d\u635f\u4f24DNA\u7684\u60c5\u51b5\u4e0b\u6572\u9664\u975e\u7f16\u7801\u7684RNA\uff0c\u800c\u8fd9\u4f1a\u5f15\u53d1\u4e00\u7cfb\u5217\u7684\u8131\u9776\u6548\u5e94\u53ca\u9519\u8bef\u7684\u7ed3\u679c\u3002<\/p>\n

\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u4e00\u7cfb\u5217\u4e0d\u7f16\u7801\u86cb\u767d\u7684DNA\u53ef\u4ee5\u8f6c\u5f55\u5f62\u6210\u975e\u7f16\u7801RNA\uff0c\u800c\u8fd9\u4e00\u8fc7\u7a0b\u53ef\u4ee5\u963b\u65ad\u7ec6\u80de\u764c\u5316\uff1bAdele Murrell\u535a\u58eb\u8bf4\u9053\uff0c\u673a\u4f53\u4e2d\u7ec6\u80de\u7684\u6570\u91cf\u5f80\u5f80\u6839\u636e\u7ec6\u80de\u7684\u590d\u5236\u548c\u66ff\u6362\u800c\u8fbe\u5230\u4e00\u79cd\u52a8\u6001\u5e73\u8861\u7684\u8fc7\u7a0b\uff0c\u6709\u65f6\u5019\u63a7\u5236\u7ec6\u80de\u751f\u957f\u7684\u5f00\u5173\u4f1a\u5361\u5728\u201c\u5f00\u542f\u201d\u7684\u4f4d\u7f6e\uff0c\u4ece\u800c\u5f15\u53d1\u764c\u75c7\u3002\u968f\u7740\u80bf\u7624\u751f\u957f\u764c\u7ec6\u80de\u5c31\u4f1a\u805a\u96c6\uff0c\u764c\u7ec6\u80de\u5c31\u4f1a\u5f00\u59cb\u8131\u79bb\u539f\u59cb\u80bf\u7624\uff0c\u6539\u53d8\u5f62\u72b6\u5e76\u4e14\u901a\u8fc7\u8840\u6db2\u8f6c\u79fb\u5230\u673a\u4f53\u5176\u5b83\u7ec4\u7ec7\u4e2d\u53bb\uff0c\u8fd9\u5c31\u79f0\u4e4b\u4e3a\u764c\u75c7\u8f6c\u79fb\uff0c\u8fd9\u4e2a\u8fc7\u7a0b\u9700\u8981\u6574\u4e2a\u57fa\u56e0\u7f51\u7edc\u7684\u8c03\u63a7\u3002<\/p>\n

\"\u53cd\u601d\uff01\u79d1\u5b66\u7814\u7a76\u4e3a\u5565\u5bf990%\u7684\u57fa\u56e0\u89c6\u800c\u4e0d\u89c1\uff1f\"<\/p>\n

\u30108\u3011Cell\uff1a\u201c\u5783\u573e\u201d\u57fa\u56e0\u4e5f\u53ef\u81f4\u764c<\/p>\n

doi\uff1a10.1016\/j.cell.2015.02.043<\/strong><\/p>\n

\u5728\u8fc7\u53bb\u51e0\u5e74\u91cc\uff0c\u79d1\u5b66\u5bb6\u4eec\u5728\u957f\u975e\u7f16\u7801RNA\u529f\u80fd\u7814\u7a76\u65b9\u9762\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\uff0clncRNA\u4f5c\u4e3a\u591a\u79cd\u751f\u7269\u5b66\u8fc7\u7a0b\u7684\u91cd\u8981\u8c03\u63a7\u56e0\u5b50\uff0c\u76ee\u524d\u5df2\u7ecf\u53d1\u73b0\u5176\u5728\u591a\u79cd\u75be\u75c5\u8fc7\u7a0b\u5982\u764c\u75c7\u7684\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n

\u8fd1\u65e5\uff0c\u6765\u81ea\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u5728\u8457\u540d\u56fd\u9645\u5b66\u672f\u671f\u520acell\u5728\u7ebf\u53d1\u8868\u4e86\u4ed6\u4eec\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\uff0c\u4ed6\u4eec\u53d1\u73b0lncRNA\u7684\u4e00\u4e2a\u4e9a\u578b–\u5047\u6027\u57fa\u56e0\u53ef\u4ee5\u4f5c\u4e3a\u7ade\u4e89\u6027\u5185\u6e90RNA\uff08ceRNA\uff09\u4fc3\u8fdbBRAF\u8868\u8fbe\u548cMAPK\u6fc0\u6d3b\uff0c\u5bfc\u81f4\u764c\u75c7\u7684\u53d1\u751f\u3002<\/p>\n

\u5047\u6027\u57fa\u56e0\u662flncRNA\u7684\u4e00\u4e2a\u4e9a\u578b\uff0c\u5176\u6765\u81ea\u4e8e\u86cb\u767d\u7f16\u7801\u57fa\u56e0\uff0c\u4f46\u5931\u53bb\u4e86\u7f16\u7801\u86cb\u767d\u8d28\u7684\u80fd\u529b\uff0c\u957f\u671f\u88ab\u5f53\u4f5c\u57fa\u56e0\u7ec4\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684\u65e0\u529f\u80fd\u6027”\u5783\u573e”\u3002\u4f46\u7edd\u5927\u591a\u6570\u5047\u6027\u57fa\u56e0\u90fd\u5b58\u5728\u5177\u6709\u9ad8\u5ea6\u540c\u6e90\u6027\u5e76\u4e14\u5177\u6709\u86cb\u767d\u7f16\u7801\u529f\u80fd\u7684parental genes\uff0c\u5e76\u4e14\u80fd\u591f\u53c2\u4e0e\u5176parental genes\u7684\u8f6c\u5f55\u540e\u8c03\u63a7\u3002<\/p>\n

\u30109\u3011Neuron\uff1a\u79d1\u5b66\u5bb6\u53d1\u73b0\u201c\u5783\u573e\u201dDNA\u6216\u662f\u5f15\u53d1\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u7f6a\u9b41\u7978\u9996<\/p>\n

doi\uff1a10.1016\/j.neuron.2013.10.053<\/strong><\/p>\n

\u53cd\u8f6c\u5f55\u8f6c\u5ea7\u5b50\u957f\u88ab\u8ba4\u4e3a\u662f\u201c\u5783\u573eDNA\u201d\uff0c\u4f46\u662f\u8fd1\u65e5\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Neuron\u4e0a\u7684\u7814\u7a76\u62a5\u9053\u4e2d\uff0c\u6765\u81ea\u4e1c\u4eac\u5927\u5b66\u7b49\u5904\u7684\u7814\u7a76\u8005\u79f0\uff0c\u8fd9\u79cd\u5783\u573eDNA\u6216\u8bb8\u5728\u7cbe\u795e\u5206\u88c2\u75c7\u53d1\u75c5\u8fc7\u7a0b\u4e2d\u626e\u6f14\u7740\u91cd\u8981\u89d2\u8272\uff1b\u7814\u7a76\u8005\u5728\u6587\u4e2d\u53d1\u73b0\uff0c\u4e00\u79cd\u540d\u4e3aLINE-1\u7684\u53cd\u8f6c\u5f55\u8f6c\u5ea7\u5b50\u5728\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u7684\u5927\u8111\u4e2d\u6c34\u5e73\u5f88\u9ad8\uff0c\u800c\u4e14\u5176\u53ef\u4ee5\u4fee\u9970\u548c\u7cbe\u795e\u5206\u88c2\u75c7\u76f8\u5173\u7684\u57fa\u56e0\u7684\u8868\u8fbe\u60c5\u51b5\uff0c\u56e0\u6b64\u7814\u7a76\u8005\u63a8\u6d4b\u5176\u53ef\u80fd\u662f\u5f15\u53d1\u7cbe\u795e\u5206\u88c2\u75c7\u53d1\u751f\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/p>\n

\u53cd\u8f6c\u5f55\u8f6c\u5ea7\u5b50\u5373\u4e3a\u77ed\u7684DNA\u5e8f\u5217\uff0c\u5176\u53ef\u4ee5\u6cbf\u7740\u57fa\u56e0\u7ec4\u4e0d\u65ad\u5ef6\u4f38\u6269\u5f20\uff0c\u4e00\u79cd\u540d\u4e3a\u957f\u6563\u5728\u91cd\u590d\u5e8f\u5217\uff08Long Interspersed Nuclear Elements\uff0cLINE\uff09\u7684\u53cd\u8f6c\u5f55\u8f6c\u5ea7\u5b50\u5728\u771f\u6838\u7ec6\u80de\u57fa\u56e0\u7ec4\u4e2d\u5360\u636e\u7740\u5f88\u5927\u90e8\u5206\uff0c\u5176\u88ab\u8ba4\u4e3a\u548c\u8bb8\u591a\u75be\u75c5\u6bd4\u5982\u764c\u75c7\u7b49\u53d1\u751f\u76f8\u5173\u3002<\/p>\n

\"\u53cd\u601d\uff01\u79d1\u5b66\u7814\u7a76\u4e3a\u5565\u5bf990%\u7684\u57fa\u56e0\u89c6\u800c\u4e0d\u89c1\uff1f\"<\/p>\n

\u301010\u3011Cell\uff1a\u63ed\u793a\u201c\u5783\u573e\u201dDNA\u63a7\u5236\u7ec6\u80de\u53d1\u80b2\u7684\u5206\u5b50\u673a\u5236<\/p>\n

doi\uff1a10.1016\/j.cell.2013.06.052<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u520a\u767b\u5728\u56fd\u9645\u8457\u540d\u6742\u5fd7Cell\u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u6089\u5c3c\u96ea\u68a8\u767e\u5e74\u7814\u7a76\u6240\uff08Sydney’s Centenary Institute\uff09\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c\u4eba\u7c7b\u673a\u4f53DNA\u4e2d97%\u7684\u5783\u573eDNA\u867d\u7136\u5e76\u4e0d\u7f16\u7801\u4ea7\u751f\u4efb\u4f55\u86cb\u767d\u8d28\u7684\u6307\u4ee4\uff0c\u53ef\u662f\u5176\u5728\u63a7\u5236\u7ec6\u80de\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u4e5f\u626e\u6f14\u7740\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n

\u6587\u4e2d\u7814\u7a76\u8005\u63ed\u793a\u4e86\u4e00\u79cd\u4ee5\u524d\u672a\u77e5\u7684\u8c03\u8282\u57fa\u56e0\u6d3b\u6027\u7684\u5206\u5b50\u673a\u5236\uff0c\u589e\u52a0\u4e86\u6211\u4eec\u5bf9\u4e8e\u7ec6\u80de\u53d1\u80b2\u7684\u4e86\u89e3\uff0c\u800c\u4e14\u4e3a\u5f00\u53d1\u65b0\u578b\u9776\u5411\u7597\u6cd5\u63d0\u4f9b\u4e86\u601d\u8def\u3002\u7814\u7a76\u8005\u4f7f\u7528\u65b0\u4e00\u4ee3\u7684\u57fa\u56e0\u6d4b\u5e8f\u6280\u672f\u548c\u590d\u6742\u7684\u8ba1\u7b97\u673a\u5206\u6790\u6280\u672f\u63ed\u793a\u4e86\uff0c\u7279\u5b9a\u7684\u767d\u7ec6\u80de\u5982\u4f55\u4f7f\u7528\u975e\u7f16\u7801\u7684DNA\u6765\u8c03\u8282\u4e00\u7cfb\u5217\u63a7\u5236\u5f62\u72b6\u548c\u529f\u80fd\u7684\u57fa\u56e0\u7684\u6d3b\u6027\u3002<\/p>\n

\u7814\u7a76\u8005Rasko\u8868\u793a\uff0c\u6211\u4eec\u7684\u7814\u7a76\u53d1\u73b0\u975e\u5e38\u6709\u610f\u601d\uff0c\u8fd9\u4e5f\u4e3a\u6211\u4eec\u5f00\u53d1\u6cbb\u7597\u591a\u79cd\u75be\u75c5\uff0c\u5305\u62ec\u764c\u75c7\u3001\u767d\u8840\u75c5\u5728\u5185\u7684\u5f88\u591a\u75be\u75c5\u63d0\u4f9b\u4e86\u5e2e\u52a9\u3002\u4fe1\u4f7fRNA\u5728\u7ffb\u8bd1\u86cb\u767d\u8d28\u4e4b\u524d\u9700\u8981\u88ab\u8fdb\u884c\u4e00\u5b9a\u7684\u52a0\u5de5\uff0c\u4e00\u822c\u60c5\u51b5\u4e0b\uff0c\u975e\u7f16\u7801\u7684\u5185\u542b\u5b50\u9700\u8981\u88ab\u5207\u5272\u6765\u4ea7\u751f\u529f\u80fd\u6027\u86cb\u767d\u8d28\u7684\u6700\u540e\u5e8f\u5217\uff0c\u8bb8\u591a\u5185\u542b\u5b50\u90fd\u5305\u542b\u6709\u4e00\u4e9b\u77ed\u7684\u5e8f\u5217\uff0c\u4fd7\u79f0\u4e3a\u7ec8\u6b62\u5bc6\u7801\u5b50\uff0c\u5176\u53ef\u4ee5\u963b\u6b62\u86cb\u767d\u8d28\u91cd\u65b0\u8fde\u63a5\u5f62\u6210\u3002<\/p>\n

\u301011\u3011Nat Methods\uff1a\u201c\u5783\u573e\u57fa\u56e0\u201d\u5e76\u975e\u4e00\u65e0\u662f\u5904 \u7814\u7a76\u53d1\u73b0\u5176\u4e5f\u7f16\u7801\u86cb\u767d<\/p>\n

doi\uff1a10.1016\/j.cell.2013.06.052<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u520a\u767b\u5728\u56fd\u9645\u8457\u540d\u6742\u5fd7Cell\u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u6089\u5c3c\u96ea\u68a8\u767e\u5e74\u7814\u7a76\u6240\uff08Sydney’s Centenary Institute\uff09\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c\u4eba\u7c7b\u673a\u4f53DNA\u4e2d97%\u7684\u5783\u573eDNA\u867d\u7136\u5e76\u4e0d\u7f16\u7801\u4ea7\u751f\u4efb\u4f55\u86cb\u767d\u8d28\u7684\u6307\u4ee4\uff0c\u53ef\u662f\u5176\u5728\u63a7\u5236\u7ec6\u80de\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u4e5f\u626e\u6f14\u7740\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n

\u6587\u4e2d\u7814\u7a76\u8005\u63ed\u793a\u4e86\u4e00\u79cd\u4ee5\u524d\u672a\u77e5\u7684\u8c03\u8282\u57fa\u56e0\u6d3b\u6027\u7684\u5206\u5b50\u673a\u5236\uff0c\u589e\u52a0\u4e86\u6211\u4eec\u5bf9\u4e8e\u7ec6\u80de\u53d1\u80b2\u7684\u4e86\u89e3\uff0c\u800c\u4e14\u4e3a\u5f00\u53d1\u65b0\u578b\u9776\u5411\u7597\u6cd5\u63d0\u4f9b\u4e86\u601d\u8def\u3002\u7814\u7a76\u8005\u4f7f\u7528\u65b0\u4e00\u4ee3\u7684\u57fa\u56e0\u6d4b\u5e8f\u6280\u672f\u548c\u590d\u6742\u7684\u8ba1\u7b97\u673a\u5206\u6790\u6280\u672f\u63ed\u793a\u4e86\uff0c\u7279\u5b9a\u7684\u767d\u7ec6\u80de\u5982\u4f55\u4f7f\u7528\u975e\u7f16\u7801\u7684DNA\u6765\u8c03\u8282\u4e00\u7cfb\u5217\u63a7\u5236\u5f62\u72b6\u548c\u529f\u80fd\u7684\u57fa\u56e0\u7684\u6d3b\u6027\u3002<\/p>\n

\u7814\u7a76\u8005Rasko\u8868\u793a\uff0c\u6211\u4eec\u7684\u7814\u7a76\u53d1\u73b0\u975e\u5e38\u6709\u610f\u601d\uff0c\u8fd9\u4e5f\u4e3a\u6211\u4eec\u5f00\u53d1\u6cbb\u7597\u591a\u79cd\u75be\u75c5\uff0c\u5305\u62ec\u764c\u75c7\u3001\u767d\u8840\u75c5\u5728\u5185\u7684\u5f88\u591a\u75be\u75c5\u63d0\u4f9b\u4e86\u5e2e\u52a9\u3002\u4fe1\u4f7fRNA\u5728\u7ffb\u8bd1\u86cb\u767d\u8d28\u4e4b\u524d\u9700\u8981\u88ab\u8fdb\u884c\u4e00\u5b9a\u7684\u52a0\u5de5\uff0c\u4e00\u822c\u60c5\u51b5\u4e0b\uff0c\u975e\u7f16\u7801\u7684\u5185\u542b\u5b50\u9700\u8981\u88ab\u5207\u5272\u6765\u4ea7\u751f\u529f\u80fd\u6027\u86cb\u767d\u8d28\u7684\u6700\u540e\u5e8f\u5217\uff0c\u8bb8\u591a\u5185\u542b\u5b50\u90fd\u5305\u542b\u6709\u4e00\u4e9b\u77ed\u7684\u5e8f\u5217\uff0c\u4fd7\u79f0\u4e3a\u7ec8\u6b62\u5bc6\u7801\u5b50\uff0c\u5176\u53ef\u4ee5\u963b\u6b62\u86cb\u767d\u8d28\u91cd\u65b0\u8fde\u63a5\u5f62\u6210\u3002<\/p>\n

\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span><\/p>\n

\u76f8\u7ea6\u5e7f\u5dde\u4e28\u7b2c\u4e5d\u5c4a\u4e2d\u56fd\u5206\u5b50\u8bca\u65ad\u6280\u672f\u5927\u4f1a\u7b49\u60a8\u6765\uff01<\/span><\/a>
<\/strong><\/span><\/p>\n


<\/p>\n

<\/span><\/a>\u52a0\u5165\u57fa\u56e0\u4ff1\u4e50\u90e8  \u83b7\u53d6\u6700\u65b0\u884c\u4e1a\u62a5\u544a<\/span><\/a>
<\/strong><\/span><\/p>\n


<\/p>\n

\u201c\u771f\u201d\u77e5\u707c\u89c1\uff0c\u201c\u56fa\u201d\u672c\u6eaf\u6e90\uff1a\u9ad8\u901a\u91cf\u6d4b\u5e8f\u80bf\u7624\u4e34\u5e8a\u7ea7\u5e94\u7528\u4ea7\u54c1\u6807\u51c6\u5316\u4e0e\u5b9a\u5236\u5316\u6a21\u5f0f  \u4e13\u9898\u536b\u661f\u4f1a<\/a><\/span><\/p>\n


<\/span><\/p>\n

\u5168\u56fd1271\u5bb6\u7b2c\u4e09\u65b9\u533b\u5b66\u68c0\u9a8c\u5b9e\u9a8c\u5ba4\u540d\u5355\u6c47\u603b<\/span><\/a>
<\/span><\/p>\n


<\/span><\/p>\n

\u5317\u3001\u4e0a\u3001\u5e7f\u3001\u6df1\u3001\u5929239\u5bb6\u72ec\u7acb\u7b2c\u4e09\u65b9\u533b\u5b66\u68c0\u9a8c\u6240\uff08\u5ba4\uff09\u540d\u5355<\/span><\/a>
<\/span><\/p>\n


<\/p>\n

\u4e09\u5bb6\u57fa\u56e0\u68c0\u6d4b\u516c\u53f8\u5165\u90092018\u5e74\u4e2d\u56fd\u5927\u5065\u5eb7\u4ea7\u4e1a\u6700\u5177\u6295\u8d44\u4ef7\u503c\u4f01\u4e1aTOP10<\/a><\/span><\/p>\n


<\/p>\n

\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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