{"id":50059,"date":"2018-09-20T01:00:00","date_gmt":"2018-09-26T02:04:59","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e5%9f%ba%e5%9b%a0%e6%a3%80%e6%b5%8b%e8%a1%8c%e4%b8%9a%e8%a6%81%e9%97%bb%e9%80%9f%e9%80%92\/"},"modified":"2018-09-26T10:05:02","modified_gmt":"2018-09-26T02:05:02","slug":"%e5%9f%ba%e5%9b%a0%e6%a3%80%e6%b5%8b%e8%a1%8c%e4%b8%9a%e8%a6%81%e9%97%bb%e9%80%9f%e9%80%92","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/50059\/","title":{"rendered":"\u57fa\u56e0\u68c0\u6d4b\u884c\u4e1a\u8981\u95fb\u901f\u9012"},"content":{"rendered":"
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\"\u57fa\u56e0\u68c0\u6d4b\u884c\u4e1a\u8981\u95fb\u901f\u9012\"<\/p>\n

\u4e2d\u6e90\u534f\u548c3\u4f4d\u8463\u4e8b\u96c6\u4e2d\u8f9e\u804c \u6216\u4e3a\u65b0\u8d44\u65b9\u8fdb\u5165\u8463\u4e8b\u4f1a\u505a\u817e\u632a<\/span><\/h1>\n

\"\u57fa\u56e0\u68c0\u6d4b\u884c\u4e1a\u8981\u95fb\u901f\u9012\"<\/p>\n

9\u670818\u65e5\u665a\u95f4\uff0c\u4e2d\u6e90\u534f\u548c\u7ec6\u80de\u57fa\u56e0\u5de5\u7a0b\u80a1\u4efd\u6709\u9650\u516c\u53f8\u516c\u544a\u79f0\uff0c\u8463\u4e8b\u4f1a\u6536\u5230\u4e09\u4f4d\u8463\u4e8b\u63d0\u4ea4\u7684\u4e66\u9762\u8f9e\u5448\u3002\u516c\u544a\u79f0\uff0c\u66f2\u4e07\u6210\u3001\u5e9e\u4e16\u8000\u3001\u5e08\u9e3f\u7fd4\u4e09\u4f4d\u8463\u4e8b\u56e0\u5de5\u4f5c\u8c03\u914d\u539f\u56e0\u5411\u516c\u53f8\u8f9e\u53bb\u7b2c\u4e5d\u5c4a\u8463\u4e8b\u4f1a\u8463\u4e8b\u548c\u4e13\u4e1a\u59d4\u5458\u4f1a\u59d4\u5458\u804c\u52a1\u3002
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\u4e2d\u6e90\u534f\u548c\u7b2c\u4e5d\u5c4a\u8463\u4e8b\u4f1a\u4efb\u671f\u5e94\u8be5\u662f\u52302020\u5e747\u670831\u65e5\uff0c\u75316\u540d\u8463\u4e8b\u30013\u540d\u72ec\u7acb\u8463\u4e8b\u7ec4\u6210\u30023\u4f4d\u8463\u4e8b\u7a81\u7136\u96c6\u4e2d\u8f9e\u804c\uff0c\u6216\u662f\u4e3a\u521a\u521a\u6536\u8d2d\u7684\u4e0a\u6d77\u50b2\u6e90\u65b9\u9762\u8fdb\u5165\u516c\u53f8\u8463\u4e8b\u4f1a\u505a\u94fa\u57ab\u3002<\/p>\n

\u4e3a\u4e86\u5b8c\u5584\u7cbe\u51c6\u8bca\u65ad\u7684\u5168\u4ea7\u4e1a\u94fe\u5e03\u5c40\uff0c\u4e2d\u6e90\u534f\u548c\u57282018\u5e74\u5b8c\u6210\u4e86\u5bf9\u56fd\u9645\u77e5\u540d\u751f\u7269\u79d1\u7814\u4f01\u4e1a\u50b2\u9510\u4e1c\u6e90\u7684\u6536\u8d2d\uff0c\u5e76\u5df2\u7ecf\u5b8c\u6210\u4e86\u8d44\u4ea7\u8fc7\u6237\u3002\u4e2d\u6e90\u534f\u548c\u4e00\u76f4\u8868\u793a\uff0c\u5bf9\u50b2\u9510\u4e1c\u6e90\u7684\u6536\u8d2d\u4e0d\u4ec5\u53ef\u4ee5\u5b9e\u73b0\u4f18\u52bf\u4e92\u8865\uff0c\u6253\u9020\u5305\u62ec\u751f\u5316\u8bca\u65ad+\u514d\u75ab\u8bca\u65ad+\u57fa\u56e0\u8bca\u65ad+\u7ec6\u80de\u6cbb\u7597\u5728\u5185\u7684\u6574\u4f53\u7cbe\u51c6\u533b\u7597\u4ea7\u4e1a\u94fe\uff0c\u8986\u76d6\u76ee\u524d\u7cbe\u51c6\u533b\u7597\u5e02\u573a\u7684\u4e3b\u8981\u70ed\u70b9\u9886\u57df\uff0c<\/p>\n

\u5728\u5229\u6da6\u8d21\u732e\u4e0a\uff0c\u4e0a\u6d77\u50b2\u6e90\u4e5f\u4e3e\u8db3\u8f7b\u91cd\uff0c\u5b83\u627f\u8bfa\uff0c2018\u5e74\u5ea6\u30012019\u5e74\u5ea6\u53ca2020\u5e74\u5ea6\u6263\u9664\u975e\u7ecf\u5e38\u6027\u635f\u76ca\u540e\u5f52\u5c5e\u4e8e\u6bcd\u516c\u53f8\u80a1\u4e1c\u7684\u51c0\u5229\u6da6\u5e94\u4e0d\u4f4e\u4e8e6,500\u4e07\u5143\u30017,900\u4e07\u5143\u548c9,600\u4e07\u5143\u3002\u5982\u679c\u6536\u8d2d\u5728\u5e74\u5185\u5b9e\u65bd\u5b8c\u6210\u540e\uff0c\u5c31\u53ef\u4ee5\u5e76\u51652018\u5e74\u4e0a\u5e02\u516c\u53f8\u4e1a\u7ee9\u3002\u4e2d\u6e90\u534f\u548c\u8463\u4e8b\u4f1a\u5e2d\u4f4d\u7ed9\u65b0\u7684\u8d44\u65b9\uff0c\u4e0a\u6d77\u50b2\u6e90\u5bf9\u4e2d\u6e90\u534f\u548c\u7684\u91cd\u8981\u6027\u53ef\u89c1\u4e00\u6591\u3002<\/p>\n

\u534e\u5927\u65e0\u521b\u6280\u672f\u518d\u5347\u7ea7\uff0cNIFTY\u00ae\u5168\u56e02.0\u6b63\u5f0f\u4e0a\u5e02\uff01<\/span><\/strong><\/span><\/h2>\n
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NIFTY<\/span><\/strong>\u00ae<\/span><\/sup><\/span><\/strong><\/span>\u5168\u56e02.0<\/span><\/strong><\/p>\n

\u7387\u5148<\/strong>\u5728\u56fd\u5185\u5b9e\u73b0\u4e34\u5e8a\u8f6c\u5316<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u57fa\u56e0\u68c0\u6d4b\u884c\u4e1a\u8981\u95fb\u901f\u9012\"<\/section>\n<\/section>\n<\/section>\n
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NIFTY\u00ae<\/span><\/sup>\u5168\u56e02.0\u6b63\u5f0f\u63a8\u51fa\uff0c\u68c0\u6d4b\u5c06\u7ee7\u7eed\u6cbf\u7528NIFTY\u00ae<\/span><\/sup>\u5168\u56e01.0\u768425M\u6570\u636e\u91cf\u68c0\u6d4b\u5168\u90e8\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\u300188\u79cd\u660e\u786e\u7684\u67d3\u8272\u4f53\u7f3a\u5931\/\u91cd\u590d\u7efc\u5408\u5f81\uff0c\u540c\u65f6\u65b0\u589e\u300c\u8f6f\u9aa8\u53d1\u80b2\u4e0d\u5168\u300d\u5355\u57fa\u56e0\u75be\u75c5\u68c0\u6d4b\u5185\u5bb9\u3002 <\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u68c0\u6d4b (Noninvasive Prenatal Testing\uff0cNIPT) \u88ab\u516c\u8ba4\u4e3a\u5168\u7403\u524d\u6cbf\u7684\u4ea7\u524d\u7b5b\u67e5\u6280\u672f\uff0c\u76ee\u524d\u4e3b\u8981\u5e94\u7528\u4e8e\u4ee521-\u4e09\u4f53\u300118-\u4e09\u4f53\u548c13-\u4e09\u4f53\u4e3a\u4ee3\u8868\u7684\u80ce\u513f\u67d3\u8272\u4f53\u5f02\u5e38\u7684\u7b5b\u67e5\u3002\u968f\u7740\u6280\u672f\u7684\u65e5\u76ca\u8fdb\u6b65\uff0c\u5176\u5e94\u7528\u8303\u56f4\u4e5f\u5728\u4e0d\u65ad\u6269\u5c55\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u68c0\u6d4b\u673a\u6784\u5c06\u65e0\u521b\u7684\u68c0\u6d4b\u8303\u56f4\u6269\u5c55\u5230\u66f4\u591a\u7684\u67d3\u8272\u4f53\u7f3a\u5931\/\u91cd\u590d\u7efc\u5408\u5f81\u3002
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\u7136\u800c\uff0c\u56fd\u5185\u65e0\u521b\u6280\u672f\u5728\u5355\u57fa\u56e0\u75be\u75c5\u68c0\u6d4b\u7684<\/span>\u4e34\u5e8a\u5e94\u7528\u4e00\u76f4\u5904\u4e8e\u7a7a\u767d\u72b6\u6001\u3002\u8fd9\u6b21\u534e\u5927\u65e0\u521b\u6280\u672f\u5728\u4eca\u5e74\u521d\u53d1\u5e03\u7684NIFTY<\/span>\u00ae<\/span><\/sup><\/span>\u5168\u56e01.0 <\/span>(\u4e86\u89e3\u8be6\u60c5) <\/a><\/span>\u57fa\u7840\u4e0a\u518d\u6b21\u5347\u7ea7\u81f3<\/span>NIFTY<\/strong><\/span>\u00ae<\/span><\/sup><\/strong><\/span>\u5168\u56e02.0\u7248\u672c\uff0c\u5728\u539f\u670925M\u6570\u636e\u91cf\u3001\u68c0\u6d4b\u5168\u90e8\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\u300188\u79cd\u660e\u786e\u7684\u67d3\u8272\u4f53\u7f3a\u5931\/\u91cd\u590d\u7efc\u5408\u5f81\u7684\u57fa\u7840\u4e0a\uff0c\u65b0\u589e\u4e86\u65e0\u521b\u5355\u57fa\u56e0\u75be\u75c5\u7684\u68c0\u6d4b\u5185\u5bb9<\/strong><\/span>\u3002<\/strong>NIFTY\u00ae<\/span><\/sup>\u5168\u56e02.0\u7684\u6b63\u5f0f\u63a8\u51fa\u6807\u5fd7\u7740\u6211\u56fd\u7684\u65e0\u521b\u6280\u672f\u53ef\u4ee5\u9996\u6b21\u5b9e\u73b0\u901a\u8fc7\u4e00\u6b21\u6027\u91c7\u96c6\u6bcd\u4f53\u5916\u5468\u8840\uff0c\u5bf9\u80ce\u513f\u4ece\u67d3\u8272\u4f53\u5230\u5355\u57fa\u56e0\u75be\u75c5\u591a\u65b9\u4f4d\u7684\u65e0\u521b\u7b5b\u67e5\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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NIFTY<\/span>\u00ae<\/span><\/sup>\u5168\u56e02.0\u6b63\u5f0f\u63a8\u51fa\uff0c\u68c0\u6d4b\u5c06\u7ee7\u7eed\u6cbf\u7528NIFTY<\/span>\u00ae<\/span><\/sup>\u5168\u56e01.0\u768425M\u6570\u636e\u91cf\u68c0\u6d4b\u5168\u90e8\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\u300188\u79cd\u660e\u786e\u7684\u67d3\u8272\u4f53\u7f3a\u5931\/\u91cd\u590d\u7efc\u5408\u5f81\uff0c<\/span>\u540c\u65f6\u65b0\u589e\u300c\u8f6f\u9aa8\u53d1\u80b2\u4e0d\u5168\u300d\u5355\u57fa\u56e0\u75be\u75c5\u68c0\u6d4b\u5185\u5bb9\u3002 <\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u8bfa\u552f\u8d5e\u4ea7\u54c1\u518d\u767bCell<\/span><\/strong><\/span><\/h2>\n

\"\u57fa\u56e0\u68c0\u6d4b\u884c\u4e1a\u8981\u95fb\u901f\u9012\"<\/p>\n

2018\u5e749\u670813\u65e5\uff0c\u751f\u7269\u5b66\u6743\u5a01\u6742\u5fd7\u300aCell\u300b\u520a\u767b\u4e86\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u803f\u7f8e\u7389\u8bfe\u9898\u7ec4\u3001\u4e01\u5065\u8bfe\u9898\u7ec4\u548c\u8c2d\u654f\u4f73\u8bfe\u9898\u7ec4\u53d1\u8868\u7684\u6587\u7ae0\uff0c\u9898\u4e3aTargeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumor\uff0c\u4e3b\u8981\u9610\u8ff0\u4e86\u9488\u5bf9\u80bf\u7624\u8868\u89c2\u9057\u4f20\u5f02\u5e38\u7684\u7cbe\u51c6\u6cbb\u7597\u7b56\u7565\u7684\u8054\u5408\u653b\u5173\u6210\u679c\u3002\u8be5\u7814\u7a76\u805a\u7126\u76ee\u524d\u80bf\u7624\u8868\u89c2\u9057\u4f20\u6297\u80bf\u7624\u836f\u7269\u7684\u4e34\u5e8a\u7528\u836f\u56f0\u5883\uff0c\u63ed\u793a\u4e86\u51b3\u5b9a\u7ec4\u86cb\u767d\u7532\u57fa\u8f6c\u79fb\u9176EZH2\u6291\u5236\u5242\u5b9e\u4f53\u7624\u7597\u6548\u54cd\u5e94\u7684\u6838\u5fc3\u673a\u5236\uff0c\u63d0\u51fa\u4e86\u65b0\u7684\u80bf\u7624\u5206\u7fa4\u7b56\u7565\u548c\u8054\u5408\u7528\u836f\u65b9\u6848\uff0c\u4e3a\u5e7f\u5927EZH2\u9ad8\u8868\u8fbe\u80bf\u7624\u7684\u4e2a\u6027\u5316\u6cbb\u7597\u6307\u660e\u4e86\u65b9\u5411\u3002<\/span>
<\/span><\/p>\n

\u8bfa\u552f\u8d5e\uff08Vazyme\uff09\u7684HiScript II 1st Strand cDNA Synthesis Kit\uff08+gDNA wiper\uff09\uff08R212\uff09<\/strong>\u4e0eChamQ SYBR qPCR Master Mix\uff08Q311\uff09<\/strong>\u5b9a\u91cfPCR\u4ea7\u54c1\u52a9\u529b\u8be5\u9879\u7814\u7a76\uff0c\u5bf9\u5176\u4e2d\u7ec4\u86cb\u767d\u7532\u57fa\u8f6c\u79fb\u9176MLL1\u7684\u57fa\u56e0\u8868\u8fbe\u6c34\u5e73\u8fdb\u884c\u4e86\u7cbe\u51c6\u5b9a\u91cf\uff0c\u53d1\u73b0MLL1\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u91cf\u5dee\u5f02\u662f\u51b3\u5b9a\u7ec4\u86cb\u767dH3K27\u4f4d\u4e0a\u7532\u57fa\u5316\uff08H3K27me\uff09\u4e0e\u4e59\u9170\u5316\uff08H3K27ac\uff09\u4e4b\u95f4\u8f6c\u5316\u7684\u5173\u952e\u3002\u8bfa\u552f\u8d5e\u7684\u4e00\u94fecDNA\u5408\u6210\u9006\u8f6c\u5f55\u8bd5\u5242\u76d2\u5177\u6709\u70ed\u7a33\u5b9a\u6027\u5f3a\u3001\u951a\u5b9aoligo\uff08dT\uff09\u7279\u5f02\u6027\u9ad8\u3001\u68c0\u6d4b\u7075\u654f\u5ea6\u9ad8\u7b49\u7279\u70b9\uff0c\u5e76\u4e14\u5305\u542b\u57fa\u56e0\u7ec4\u53bb\u9664\u6a21\u5757\uff0c\u80fd\u591f\u4fdd\u8bc1\u7b2c\u4e00\u94fecDNA\u5408\u6210\u6548\u7387\u548c\u6210\u529f\u7387\u3002\u6b64\u5916\uff0c\u6297\u4f53\u6cd5\u70ed\u542f\u52a8\u8367\u5149\u5b9a\u91cf\u9884\u6df7\u6db2\u6269\u589e\u7a33\u5b9a\u3001\u7075\u654f\u5ea6\u9ad8\u3001\u7279\u5f02\u578b\u5f3a\uff0c\u5b9a\u91cf\u7ed3\u679c\u5177\u6709\u9ad8\u5ea6\u91cd\u590d\u6027\u3002\u4e3a\u80bf\u7624\u751f\u7269\u5b66\u7684\u7814\u7a76\u4fdd\u9a7e\u62a4\u822a\uff01<\/span><\/p>\n

\u6db2\u4f53\u6d3b\u68c0\u5e73\u53f0E\u8f6e\u878d\u8d445200\u4e07\u7f8e\u5143<\/span><\/h1>\n

\u65e5\u524d\uff0cEpic Sciences\u5ba3\u5e03\u5b8c\u6210E\u8f6e5200\u4e07\u7f8e\u5143\u7684\u878d\u8d44\u3002\u672c\u8f6e\u6295\u8d44\u7531Blue Ox Healthcare Partners\u9886\u6295\uff0cDeerfield Management\u548cVarian\u5171\u540c\u53c2\u4e0e\u3002\u6b64\u5916\uff0c\u5305\u62ecAltos Capital Partners\u3001Genomic Health\u3001Domain Associates\u3001VI Ventures\u3001Alexandria Venture Investments\u548cSabby Management\u5728\u5185\u7684\u73b0\u6709\u6295\u8d44\u8005\u4e5f\u90fd\u53c2\u4e0e\u4e86\u672c\u8f6e\u878d\u8d44\u3002<\/p>\n


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\"\u57fa\u56e0\u68c0\u6d4b\u884c\u4e1a\u8981\u95fb\u901f\u9012\"<\/p>\n


<\/p>\n

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\u4f34\u968f\u8bca\u65ad\u5b9e\u73b0\u201c\u540c\u764c\u5f02\u6cbb\u201d<\/strong><\/p>\n<\/section>\n

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\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span><\/p>\n

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<\/p>\n

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