{"id":50068,"date":"2018-09-20T01:00:00","date_gmt":"2018-09-26T02:05:05","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e5%a4%9a%e7%af%87%e6%96%87%e7%ab%a0%e8%a7%a3%e8%af%bbdna%e6%8d%9f%e4%bc%a4%e9%a2%86%e5%9f%9f%e9%87%8d%e8%a6%81%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c\/"},"modified":"2018-09-26T10:05:06","modified_gmt":"2018-09-26T02:05:06","slug":"%e5%a4%9a%e7%af%87%e6%96%87%e7%ab%a0%e8%a7%a3%e8%af%bbdna%e6%8d%9f%e4%bc%a4%e9%a2%86%e5%9f%9f%e9%87%8d%e8%a6%81%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/50068\/","title":{"rendered":"\u591a\u7bc7\u6587\u7ae0\u89e3\u8bfbDNA\u635f\u4f24\u9886\u57df\u91cd\u8981\u7814\u7a76\u6210\u679c"},"content":{"rendered":"
\n

\"\u591a\u7bc7\u6587\u7ae0\u89e3\u8bfbDNA\u635f\u4f24\u9886\u57df\u91cd\u8981\u7814\u7a76\u6210\u679c\"<\/p>\n

\u6211\u4eec\u90fd\u77e5\u9053\uff0c\u673a\u4f53DNA\u635f\u4f24\u5982\u679c\u5f97\u4e0d\u5230\u53ca\u65f6\u4fee\u590d\u5c31\u4f1a\u5f15\u53d1\u4e00\u7cfb\u5217\u5065\u5eb7\u5371\u5bb3\uff0c\u6bd4\u5982\u764c\u75c7\u6216\u8870\u8001\u7b49\uff0c\u8fd1\u5e74\u6765\u79d1\u5b66\u5bb6\u4eec\u5728DNA\u635f\u4f24\u9886\u57df\u8fdb\u884c\u4e86\u6df1\u5165\u7814\u7a76\u5e76\u53d6\u5f97\u4e86\u4e00\u7cfb\u5217\u6210\u679c\uff0c\u672c\u6587\u4e2d\uff0c\u5c0f\u7f16\u6574\u7406\u4e86\u76f8\u5173\u7814\u7a76\u62a5\u544a\uff0c\u5206\u4eab\u7ed9\u5927\u5bb6\uff01<\/span><\/p>\n

\"\u591a\u7bc7\u6587\u7ae0\u89e3\u8bfbDNA\u635f\u4f24\u9886\u57df\u91cd\u8981\u7814\u7a76\u6210\u679c\"<\/p>\n

\u30101\u3011Nature\uff1a\u8b66\u60d5\uff01\u9633\u5149\u9020\u6210\u7684DNA\u635f\u4f24\u5f88\u96be\u4fee\u590d<\/span><\/p>\n

\u65b0\u95fb\u9605\u8bfb\uff1aStay sun safe for your DNA<\/span><\/p>\n

\u6765\u81ea\u65b0\u5357\u5a01\u5c14\u58eb\u5927\u5b66\u7684\u764c\u75c7\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\u6211\u4eecDNA\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u5728\u9633\u5149\u7167\u5c04\u4ea7\u751f\u635f\u4f24\u540e\u5e76\u4e0d\u5bb9\u6613\u88ab\u4fee\u590d\u8fd8\u539f\u3002<\/span><\/p>\n

\u8fd9\u9879\u53d1\u73b0\u4e8e\u8fd1\u65e5\u53d1\u8868\u5728\u300aNature\u300b\u4e0a\uff0c\u5c06\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u660e\u767d\u7a81\u53d8\u4e3a\u4ec0\u4e48\u4f1a\u5bcc\u96c6\u5728\u6211\u4eecDNA\u4e2d\u7684\u67d0\u4e9b\u90e8\u5206\u3002\u4e3a\u4e86\u8fd9\u9879\u7814\u7a76\uff0cRebecca Poulos\u535a\u58eb\u53ca\u5176\u540c\u4e8b\u7814\u7a76\u4e86\u8d85\u8fc71000\u4e2a\u80bf\u7624\u6837\u54c1\u4e2d\u7684DNA\u7a81\u53d8\uff0c\u4ee5\u66f4\u6df1\u5165\u5730\u660e\u767d\u80bf\u7624\u5982\u4f55\u5f62\u6210\u53ca\u751f\u957f\u3002<\/span><\/p>\n

\u201c\u6211\u4eec\u7684\u57fa\u56e0\u5bf9\u6211\u4eec\u7684\u7ec6\u80de\u7684\u529f\u80fd\u975e\u5e38\u91cd\u8981\u3002\u201d Rebecca\u89e3\u91ca\u9053\u3002\u201c\u6211\u4eec\u5df2\u7ecf\u7814\u7a76\u4e86\u6211\u4eecDNA\u4e2d\u8c03\u8282\u7ec6\u80de\u4e2d\u7684\u57fa\u56e0\u7684\u8868\u8fbe\u91cf\u7684\u90e8\u5206\u3002\u201d<\/span><\/p>\n

\u30102\u3011Nat Commun\uff1a\u79d1\u5b66\u5bb6\u6210\u529f\u7ed8\u5236\u51fa\u4e0e\u4eba\u7c7b\u9ed1\u8272\u7d20\u7624\u53d1\u751f\u76f8\u5173DNA\u635f\u4f24\u56fe\u8c31<\/span><\/p>\n

doi\uff1a10.1038\/s41467-018-05064-0<\/span><\/p>\n

\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Nature Communications\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u534e\u76db\u987f\u5dde\u7acb\u5927\u5b66\u548c\u4e54\u6cbb\u4e9a\u5dde\u7acb\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u8054\u5408\u7814\u7a76\u7ed8\u5236\u51fa\u4e86\u9ed1\u8272\u7d20\u7624\u590d\u53d1\u6027\u7a81\u53d8\u7684\u5173\u952e\u73af\u8282\u56fe\u8c31\uff0c\u9ed1\u8272\u7d20\u7624\u662f\u4e00\u79cd\u4eba\u7c7b\u6700\u4e25\u91cd\u7684\u76ae\u80a4\u764c\u3002<\/span><\/p>\n

\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u8005\u53d1\u73b0\uff0c\u901a\u8fc7\u540d\u4e3aETS\u7684\u7279\u5b9a\u8f6c\u5f55\u56e0\u5b50\u8fdb\u884c\u7684DNA\u7ed3\u5408\u4f5c\u7528\u6216\u8bb8\u4f1a\u5728\u66b4\u9732\u4e8e\u7d2b\u5916\u7ebf\uff08UV\uff09\u7684\u7ec6\u80de\u4e2d\u672c\u8eab\u5c31\u5904\u4e8e\u7a81\u53d8\u72b6\u6001\uff0c\u968f\u7740\u65b0\u578b\u57fa\u56e0\u7ec4\u56fe\u8c31\u7ed8\u5236\u6280\u672f\u7684\u53d1\u5c55\u548c\u5e94\u7528\uff0c\u76f8\u5173\u7684\u7814\u7a76\u53d1\u73b0\u6216\u80fd\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u7406\u89e3\u4e3a\u4f55\u4f1a\u5728\u7279\u6b8a\u57fa\u56e0\u7684ETS\u7ed3\u5408\u4f4d\u70b9\u5904\u53d1\u751f\u7a81\u53d8\uff0c\u800c\u8fd9\u88ab\u8ba4\u4e3a\u80fd\u591f\u9a71\u52a8\u4eba\u7c7b\u9ed1\u8272\u7d20\u7624\u53d1\u751f\u7684\u5f00\u7aef\u3002<\/span><\/p>\n

\"\u591a\u7bc7\u6587\u7ae0\u89e3\u8bfbDNA\u635f\u4f24\u9886\u57df\u91cd\u8981\u7814\u7a76\u6210\u679c\"<\/p>\n

\u30103\u3011PNAS\uff1a\u7535\u5b50\u70df\u80fd\u591f\u5bfc\u81f4DNA\u635f\u4f24\uff0c\u589e\u52a0\u764c\u75c7\u98ce\u9669<\/span><\/p>\n

doi\uff1a10.1073\/pnas.1718185115<\/span><\/p>\n

\u4e00\u9879\u65b0\u7684\u7814\u7a76\u8868\u660e\u5728\u5438\u7535\u5b50\u70df\uff08e-cigarette\uff09\u65f6\u5438\u5165\u7684\u5c3c\u53e4\u4e01\u4f1a\u8ba9\u5c0f\u9f20\u5fc3\u810f\u3001\u80ba\u90e8\u548c\u8180\u80f1\u4e2d\u7684DNA\u906d\u53d7\u635f\u4f24\uff0c\u800c\u4e14\u4e5f\u4f1a\u8ba9\u4f53\u5916\u57f9\u517b\u7684\u4eba\u80ba\u7ec6\u80de\u548c\u8180\u80f1\u7ec6\u80de\u4e2d\u7684DNA\u906d\u53d7\u635f\u4f24\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e741\u670829\u65e5\u5728\u7ebf\u53d1\u8868PNAS\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cE-cigarette smoke damages DNA and reduces repair activity in mouse lung\uff0c heart\uff0c and bladder as well as in human lung and bladder cells\u201d\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u63d0\u793a\u7740\u5438\u7535\u5b50\u70df\u4f1a\u589e\u52a0\u60a3\u4e0a\u764c\u75c7\u548c\u5fc3\u810f\u75c5\u7684\u98ce\u9669\uff0c\u5e76\u5e94\u52a0\u5f3a\u5f00\u5c55\u8868\u660e\u5438\u7535\u5b50\u70df\u5bf9\u4eba\u7c7b\u5065\u5eb7\u98ce\u9669\u7684\u7814\u7a76\u3002<\/span><\/p>\n

\u7814\u7a76\u8005Moon-shong Tang\u8bf4\uff0c\u8fd9\u79cdDNA\u53d8\u5316\u7c7b\u4f3c\u4e8e\u4e0e\u4e8c\u624b\u70df\u76f8\u5173\u7684\u90a3\u4e9b\u53d8\u5316\u3002\u5177\u4f53\u6765\u8bf4\uff0cTang\u53ca\u5176\u56e2\u961f\u5728\u66b4\u9732\u4e8e\u7535\u5b50\u70df\u70df\u96fe\u4e2d\u7684\u80ba\u7ec6\u80de\u3001\u8180\u80f1\u7ec6\u80de\u548c\u5fc3\u810f\u7ec6\u80de\u4e2d\u53d1\u73b0\u4e86\u4e24\u79cd\u8bf1\u5bfc\u7a81\u53d8\u7684\u5316\u5408\u7269\u3002DNA\u4fee\u590d\u6d3b\u6027\u4ee5\u53ca\u4fee\u590d\u86cb\u767dXPC\u548cOGG1\/2\u7684\u8868\u8fbe\u5728\u63a5\u89e6\u8fc7\u7535\u5b50\u70df\u70df\u96fe\u7684\u5c0f\u9f20\u80ba\u7ec4\u7ec7\u4e2d\u4e0b\u964d\u4e86\u3002<\/span><\/p>\n

\u30104\u3011PLoS Genet\uff1a\u53c2\u4e0eDNA\u635f\u4f24\u4fee\u590d\u7684\u57fa\u56e0\u7a81\u53d8\u5bfc\u81f4\u591a\u53d1\u6027\u786c\u5316\u7684\u53d1\u751f<\/span><\/p>\n

doi\uff1a10.1371\/journal.pgen.1007111<\/span><\/p>\n

\u6700\u8fd1\uff0c\u7814\u7a76\u8005\u4eec\u53d1\u73b0\u4e86\u4e24\u4e2a\u4e0e\u591a\u53d1\u6027\u786c\u5316\u76f8\u5173\u7684\u57fa\u56e0\u4f4d\u70b9\u3002\u76f8\u5173\u7ed3\u679c\u53d1\u8868\u5728\u6700\u8fd1\u4e00\u671f\u7684\u300aPLOS genetics\u300b\u6742\u5fd7\u4e0a\u3002<\/span><\/p>\n

\u4eba\u7c7b\u7684\u8840\u7edf\u7279\u5f81\u80fd\u591f\u5e2e\u52a9\u9057\u4f20\u5b66\u5bb6\u8ffd\u8e2a\u75be\u75c5\u7684\u5bb6\u65cf\u53f2\uff0c\u4ee5\u53ca\u627e\u5230\u5173\u952e\u7684\u57fa\u56e0\u7a81\u53d8\u3002\u5bf9\u4e8e\u5355\u57fa\u56e0\u7a81\u53d8\u6765\u8bf4\u8fd9\u79cd\u624b\u6bb5\u5341\u5206\u6709\u6548\uff0c\u4f46\u5bf9\u4e8e\u590d\u6742\u7684\u75be\u75c5\u6765\u8bf4\uff0c\u8840\u7edf\u5b66\u624b\u6bb5\u5219\u8fbe\u4e0d\u5230\u76f8\u5f53\u7684\u6548\u679c\u3002\u5728\u6700\u8fd1\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u7684\u624b\u6bb5\uff0c\u80fd\u591f\u5206\u6790\u9ad8\u5371\u578b\u7684\u8840\u7edf\u7279\u5f81\uff08\u5373\u5927\u8303\u56f4\uff0c\u591a\u4ee3\u7cfb\u7684\u9057\u4f20\u75c5\uff0c\u60a3\u75c5\u4eba\u7fa4\u7684\u6570\u91cf\u8f83\u591a\uff0c\u56e0\u6b64\u4e0d\u88ab\u4eba\u4e3a\u662f\u5076\u7136\u7a81\u53d8\u5bfc\u81f4\u7684\uff09\u3002\u5229\u7528\u8fd9\u79cd\u65b9\u6cd5\uff0c\u4f5c\u8005\u5bf911\u4e2a\u5b58\u5728\u8f83\u9ad8\u7684\u60a3\u591a\u53d1\u6027\u786c\u5316\u75be\u75c5\u7684\u5bb6\u5ead\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u7ed3\u679c\u663e\u793a\uff1a\u6709\u4e24\u4e2a\u57fa\u56e0\u5bf9\u4e8e\u75be\u75c5\u7684\u53d1\u751f\u5b58\u5728\u91cd\u8981\u5f71\u54cd\u3002\u5176\u4e2d\u4e00\u4e2a\u57fa\u56e0\u53c2\u4e0e\u4e86DNA\u635f\u4f24\u7684\u4fee\u590d\uff0c\u800c\u53e6\u5916\u4e00\u4e2a\u57fa\u56e0\u5219\u53c2\u4e0e\u4e86DNA\u7684\u7ec4\u88c5\u3002<\/span><\/p>\n

\"\u591a\u7bc7\u6587\u7ae0\u89e3\u8bfbDNA\u635f\u4f24\u9886\u57df\u91cd\u8981\u7814\u7a76\u6210\u679c\"<\/p>\n

\u30105\u3011Nature\uff1a\u63ed\u793a\u996e\u9152\u5982\u4f55\u5bfc\u81f4DNA\u635f\u4f24\u548c\u589e\u52a0\u7684\u764c\u75c7\u98ce\u9669<\/span><\/p>\n

doi\uff1a10.1038\/nature25154<\/span><\/p>\n

\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u82f1\u56fd\u5251\u6865\u5927\u5b66MRC\u5206\u5b50\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4\u548c\u97e6\u5c14\u79d1\u59c6\u57fa\u91d1\u4f1a\u6851\u683c\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u8bc1\u5b9e\u4e86\u9152\u7cbe\u5982\u4f55\u5bfc\u81f4\u5e72\u7ec6\u80de\u4e2d\u7684DNA\u906d\u53d7\u635f\u4f24\uff0c\u8fd9\u6709\u52a9\u89e3\u91ca\u4e3a\u4f55\u996e\u9152\u4f1a\u589e\u52a0\u764c\u75c7\u98ce\u9669\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e741\u67083\u65e5\u5728\u7ebf\u53d1\u8868\u5728Nature\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cAlcohol and endogenous aldehydes damage chromosomes and mutate stem cells\u201d\u3002<\/span><\/p>\n

\u5728\u6b64\u4e4b\u524d\uff0c\u5f88\u591a\u63a2\u7a76\u9152\u7cbe\u5bfc\u81f4\u764c\u75c7\u7684\u786e\u5207\u673a\u5236\u7684\u7814\u7a76\u90fd\u662f\u5728\u7ec6\u80de\u57f9\u517b\u7269\u4e2d\u5f00\u5c55\u7684\u3002\u4f46\u662f\u5728\u8fd9\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u4ee5\u5c0f\u9f20\u4e3a\u5b9e\u9a8c\u5bf9\u8c61\u8bc1\u5b9e\u4e86\u9152\u7cbe\u66b4\u9732\uff08alcohol exposure\uff09\u5982\u4f55\u5bfc\u81f4\u6c38\u4e45\u6027\u7684\u9057\u4f20\u635f\u4f24\u3002<\/span><\/p>\n

\u8fd9\u4e9b\u7814\u7a76\u4eba\u5458\u7ed9\u5c0f\u9f20\u5582\u98df\u7a00\u91ca\u7684\u9152\u7cbe\uff08\u5316\u5b66\u4e0a\u88ab\u79f0\u4e3a\u4e59\u9187\uff09\u3002\u4ed6\u4eec\u968f\u540e\u901a\u8fc7\u5f00\u5c55\u67d3\u8272\u4f53\u5206\u6790\u548cDNA\u6d4b\u5e8f\u6765\u7814\u7a76\u4e59\u919b\uff08\u5f53\u8eab\u4f53\u52a0\u5de5\u9152\u7cbe\u65f6\u4ea7\u751f\u7684\u4e00\u79cd\u6709\u5bb3\u7684\u5316\u5b66\u7269\uff09\u5bfc\u81f4\u7684\u9057\u4f20\u635f\u4f24\u3002<\/span><\/p>\n

\u4ed6\u4eec\u53d1\u73b0\u4e59\u919b\u80fd\u591f\u8ba9\u9020\u8840\u5e72\u7ec6\u80de\u4e2d\u7684DNA\u906d\u53d7\u65ad\u88c2\u548c\u635f\u4f24\uff0c\u8fd9\u4f1a\u5bfc\u81f4\u8fd9\u4e9b\u7ec6\u80de\u53d1\u751f\u67d3\u8272\u4f53\u91cd\u6392\uff0c\u4ece\u800c\u6c38\u4e45\u6027\u5730\u6539\u53d8\u5b83\u4eec\u7684DNA\u5e8f\u5217\u3002<\/span><\/p>\n

\u30106\u3011Nature\uff1a\u63ed\u793a\u7ec6\u80de\u68c0\u6d4b\u70f7\u57fa\u5316DNA\u635f\u4f24\u673a\u5236\uff0c\u6709\u52a9\u6539\u8fdb\u5316\u7597\u836f\u7269\u7597\u6548<\/span><\/p>\n

doi\uff1a10.1038\/nature24484<\/span><\/p>\n

\u7ec6\u80de\u5185\u90e8\u7684\u5fd9\u788c\u4e16\u754c\u662f\u7531\u5b83\u7684DNA\u84dd\u56fe\u5f15\u5bfc\u7684\u3002\u5f53\u8fd9\u79cd\u84dd\u56fe\u53d1\u751f\u53d8\u5316\u65f6\uff0c\u7ec6\u80de\u5c31\u4f1a\u751f\u75c5\u3001\u6b7b\u4ea1\u6216\u764c\u53d8\u3002\u4e3a\u4e86\u8ba9DNA\u4fdd\u6301\u6b63\u5e38\u8fd0\u8f6c\uff0c\u7ec6\u80de\u6709\u68c0\u6d4b\u548c\u4fee\u590d\u53d7\u635fDNA\u7684\u65b9\u6cd5\u3002<\/span><\/p>\n

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doi\uff1a10.1126\/science.aam6468<\/span><\/p>\n

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\u6839\u636e\u8be5\u6587\u7ae0\u7684\u901a\u8baf\u4f5c\u8005\uff0c\u6765\u81eaNIH\u7684Scott Williams\u6559\u6388\u7684\u8bf4\u6cd5\uff0c\u7814\u7a76\u8005\u4eec\u6b64\u524d\u5df2\u7ecf\u77e5\u9053TDP2\u5bf9\u4e8e\u6e05\u9664DPC\u73b0\u8c61\u5341\u5206\u91cd\u8981\uff0c\u4f46\u4ed6\u4eec\u4e0d\u77e5\u9053\u5b83\u7684\u5177\u4f53\u5de5\u4f5c\u65b9\u5f0f\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u4eec\u5229\u7528\u591a\u79cd\u624b\u6bb5\u9274\u5b9a\u51faZATT\u662f\u8c03\u63a7\u8fd9\u4ee5\u8fc7\u7a0b\u7684\u53e6\u4e00\u5173\u952e\u86cb\u767d\u3002<\/span><\/p>\n

\u30108\u3011Nature\uff1a\u63ed\u793aDNA\u635f\u4f24\u62db\u52df\u514d\u75ab\u7ec6\u80de\u62b5\u6297\u764c\u75c7\u673a\u5236<\/span><\/p>\n

doi\uff1a10.1038\/nature23470<\/span><\/p>\n

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\u30109\u3011Science\uff1a\u91cd\u78c5\uff01\u63ed\u793a\u4e00\u79cd\u65b0\u7684DNA\u635f\u4f24\u4fee\u590d\u673a\u5236<\/span><\/p>\n

doi\uff1a10.1126\/science.aag1095   doi\uff1a10.1126\/science.aan8293<\/span><\/p>\n

DNA\u4fee\u590d\u7cfb\u7edf\u80fd\u591f\u4fee\u590d\u6d3b\u6027\u6c27\u3001\u6d3b\u6027\u7fb0\u57fa\u5316\u5408\u7269\u3001\u70f7\u5316\u5242\u3001\u7d2b\u5916\u7ebf\u8f90\u5c04\u3001\u8131\u6c27\u5c3f\u5627\u5576\u6574\u5165\u548c\u590d\u5236\u9519\u8bef\u5bfc\u81f4\u7684DNA\u635f\u4f24\u3002DNA\u4fee\u590d\u673a\u5236\u5305\u62ec\u6838\u82f7\u9178\u6c60\u6d88\u6bd2\uff08nucleotide pool sanitization\uff09\u3001\u76f4\u63a5\u4fee\u590d\uff08DR\uff09\u3001\u78b1\u57fa\u5207\u9664\u4fee\u590d\uff08BER\uff09\u3001\u6838\u82f7\u9178\u5207\u9664\u4fee\u590d\uff08NER\uff09\u3001\u9519\u914d\u4fee\u590d\uff08MMR\uff09\u3001\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\uff08HRR\uff09\u548c\u975e\u540c\u6e90\u672b\u7aef\u8fde\u63a5\uff08NHEJ\uff09\u3002<\/span><\/p>\n

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doi\uff1a10.1073\/pnas.1706021114<\/span><\/p>\n

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“\u82ef\u5e76\u8298”\u662f\u4e00\u7c7b\u7b80\u5355\u7684\u70c3\u7c7b\u5316\u5408\u7269\u3002\u79d1\u5b66\u5bb6\u4eec\u8ba4\u4e3a\u8be5\u5316\u5408\u7269\u662f\u8bb8\u591a\u4f4e\u7b49\u7684\u78b3\u57fa\u751f\u7269\u7684\u5b58\u5728\u57fa\u7840\uff0c\u4f46\u5bf9\u4e8e\u4eba\u7c7b\u7b49\u9ad8\u7ea7\u751f\u7269\u6765\u8bf4\uff0c\u8fd9\u79cd\u5206\u5b50\u53cd\u800c\u5177\u6709\u8d1f\u9762\u7684\u5f71\u54cd\u3002\u82ef\u5e76\u8298\u662f\u6709\u673a\u7269\uff0c\u4f8b\u5982\u70df\u8349\u690d\u7269\u7b49\uff0c\u71c3\u70e7\u4ea7\u751f\u7684\u526f\u4ea7\u7269\u3002\u4e00\u822c\u60c5\u51b5\u4e0b\uff0c\u6709\u6bd2\u7684\u70c3\u7c7b\u7269\u8d28\u8fdb\u5165\u6d88\u5316\u9053\u6216\u547c\u5438\u9053\u4e2d\u540e\uff0c\u4f1a\u88ab\u4f53\u5185\u7684\u9176\u964d\u89e3\u4ee5\u53bb\u9664\u6bd2\u6027\uff0c\u800c\u82ef\u5e76\u8298\u964d\u89e3\u4e4b\u540e\u4f1a\u751f\u6210\u4e00\u79cd\u53eb\u505aBPDE\u7684\u5316\u5408\u7269\uff0c\u8fd9\u4e00\u7269\u8d28\u7684\u5371\u5bb3\u8fdc\u5927\u4e8e\u82ef\u5e76\u8298\u672c\u8eab\u3002<\/span><\/p>\n

\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span><\/p>\n

<\/span><\/a>\u52a0\u5165\u57fa\u56e0\u4ff1\u4e50\u90e8  \u83b7\u53d6\u6700\u65b0\u884c\u4e1a\u62a5\u544a<\/span><\/a>
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