{"id":50089,"date":"2018-09-20T01:00:00","date_gmt":"2018-09-26T02:05:17","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e8%82%bf%e7%98%a4%e9%9d%b6%e5%90%91%e8%8d%af%e7%89%a9%e4%b8%8e%e5%9f%ba%e5%9b%a0%e6%a3%80%e6%b5%8b\/"},"modified":"2018-09-26T10:05:23","modified_gmt":"2018-09-26T02:05:23","slug":"%e8%82%bf%e7%98%a4%e9%9d%b6%e5%90%91%e8%8d%af%e7%89%a9%e4%b8%8e%e5%9f%ba%e5%9b%a0%e6%a3%80%e6%b5%8b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/50089\/","title":{"rendered":"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b"},"content":{"rendered":"
\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

\u76ee\u524d\u5df2\u7ecf\u6709\u8d85\u8fc780\u4e2a\u80bf\u7624\u5206\u5b50\u9776\u5411\u836f\u7269\u7ecfFDA\u83b7\u6279\u4e0a\u5e02\uff0c\u8fd9\u4e9b\u836f\u7269\u5305\u62ec\u4e86\u9488\u5bf9\u81f4\u764c\u57fa\u56e0\u901a\u8def\u548c\u80bf\u7624\u751f\u957f\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u548c\u5355\u514b\u9686\u6297\u4f53\u3002\u7531\u4e8e\u80bf\u7624\u7684\u5f02\u8d28\u6027\uff0c\u9776\u5411\u6cbb\u7597\u53ef\u80fd\u9488\u5bf9\u4e00\u4e9b\u80bf\u7624\u7ec6\u80de\u800c\u975e\u6240\u6709\u7684\u80bf\u7624\u7ec6\u80de\uff0c\u9776\u70b9\u7684\u68c0\u6d4b\u5bf9\u4e8e\u9776\u5411\u6cbb\u7597\u5341\u5206\u91cd\u8981\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u9776\u5411\u836f\u7269\u4e0e\u9776\u70b9<\/span><\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u4e0b\u56fe\u662f\u5404\u7624\u79cd\u7ecfFDA\u83b7\u6279\u768480\u591a\u4e2a\u836f\u7269\uff0c\u6279\u51c6\u65f6\u95f4\u4e0e\u9776\u70b9\uff0c\u548c\u9884\u6d4bbiomarker\u7684\u4fe1\u606f\uff0c\u6b64\u56fe\u622a\u81f3\u4e8e\u53bb\u5e74\u5e74\u5e95\uff0c\u81f3\u4eca\u5e74\uff0c\u53c8\u6709\u5c11\u91cf\u65b0\u9002\u5e94\u75c7\u6216\u65b0\u836f\u83b7\u6279\u3002 <\/span><\/p>\n


<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

 <\/span><\/p>\n

\u7cbe\u51c6\u533b\u7597\u5bf9\u8bca\u65ad\u7684\u9700\u6c42<\/span><\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u4e0d\u4ec5\u4ec5\u662f\u9776\u5411\u836f\u7269\u7814\u53d1\u548c\u83b7\u6279\u7684\u589e\u591a\uff0c\u57fa\u4e8e\u80bf\u7624Biomarker\u5bf9\u80bf\u7624\u4f34\u968f\u8bca\u65ad\u7684\u83b7\u6279\u4e5f\u662f\u8d8a\u6765\u8d8a\u591a\uff0c\u5982\u4e0b\u56fe\u6240\u793a\uff1a<\/span><\/p>\n

 <\/span><\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

 <\/span><\/p>\n

\u201c\u5f02\u75c5\u540c\u6cbb\uff0c\u540c\u75c5\u5f02\u6cbb\u201d\u53ef\u80fd\u662f\u672a\u6765\u80bf\u7624\u6cbb\u7597\u7684\u65b9\u5411\uff0c\u8d8a\u6765\u8d8a\u591a\u9776\u70b9\u7684\u53d1\u73b0\u53ca\u836f\u7269\u7684\u7814\u53d1\uff0c\u4f7f\u5f97\u7cbe\u51c6\u533b\u7597\u8fdb\u5165\u4e86\u65b0\u7684\u65f6\u4ee3\u3002\u57fa\u4e8e\u4e8c\u4ee3\u6d4b\u5e8f\u6280\u672f\uff0c\u76f8\u5e94\u7684\u201c\u96e8\u4f1e\u7814\u7a76\u201d\uff08Umbrella Trial\uff09\u4e0e\u7bee\u5b50\u7814\u7a76\uff08Basket Trial\uff09\u4e5f\u662f\u73b0\u5728\u975e\u5e38\u91cd\u8981\u7684\u7814\u7a76\u65b9\u5411\u3002\u4e0e\u4ee5\u5f80\u6309\u7167\u80bf\u7624\u53d1\u75c5\u5668\u5b98\u6765\u533a\u5206\u4e0d\u540c\uff0c\u7bee\u5b50\u7814\u7a76\u7684\u6cbb\u7597\u9009\u62e9\u57fa\u4e8e\u67d0\u79cd\u5206\u5b50\u53d8\u5316\u3002<\/span><\/p>\n


<\/p>\n

 \"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/span><\/p>\n


<\/p>\n

\u672a\u6765\u836f\u7269\u6108\u53d1\u589e\u591a\u3001\u9776\u70b9\u6108\u53d1\u589e\u591a\u65f6\uff0c\u80bf\u7624\u4e34\u5e8a\u5bf9NGS\u7684\u9700\u6c42\u4e5f\u4f1a\u52a0\u5927\u3002NGS\u5927Panel\u4f1a\u6839\u636e\u4e34\u5e8a\u7684\u9700\u6c42\u51fa\u73b0\u65b0\u7684\u83b7\u6279\u8fdb\u5c55\u548c\u5e02\u573a\u589e\u957f\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u9776\u5411\u836f\u7269\u4e0e\u6807\u51c6\u5316\u7597\u836f\u7269\u7684\u4f5c\u7528\u673a\u5236\u4e0d\u540c\u3002<\/strong>\u5316\u7597\u836f\u4ee5\u201c\u6740\u654c\u4e00\u5343\uff0c\u81ea\u635f\u516b\u767e\u201d\u95fb\u540d\uff0c\u526f\u4f5c\u7528\u6781\u5927\u3002\u800c\u9776\u5411\u836f\u662f\u9488\u5bf9\u6709\u7279\u5b9a\u57fa\u56e0\u7a81\u53d8\u7684\u80ba\u764c\uff0c\u4e00\u51fb\u5373\u4e2d\uff0c\u5982EGFR\u3001ALK\u3001ROS1\u3001MEK\u3001BRAF\u7b49\u7b49\uff0c\u4e14\u526f\u4f5c\u7528\u6bd4\u5316\u7597\u5927\u5927\u51cf\u5c11\u3002\u4f46\u6709\u4e00\u70b9\u5c40\u9650\u6027\uff0c\u5c31\u662f\u5fc5\u987by\u6709\u5bf9\u5e94\u7279\u5b9a\u9776\u70b9\u7a81\u53d8\u624d\u6709\u6548\u3002\u6211\u4eec\u6765\u770b\u770b\u90fd\u6709\u54ea\u4e9b\u9776\u5411\u836f\u53ef\u4f9b\u60a3\u8005\u9009\u62e9\u3002<\/p>\n

1\u3001VEGF<\/p>\n

\u8fd9\u662f\u4e00\u7c7b\u9776\u5411\u80bf\u7624\u8840\u7ba1\u751f\u6210\u7684\u836f\u7269\uff0c\u4e3a\u4e86\u4f7f\u65b0\u80bf\u7624\u751f\u957f\uff0c\u9700\u8981\u5f62\u6210\u65b0\u7684\u8840\u7ba1\u4ee5\u4fdd\u6301\u5b83\u4eec\u7684\u8425\u517b\uff0c\u8be5\u8fc7\u7a0b\u79f0\u4e3a\u8840\u7ba1\u751f\u6210\u3002\u4e00\u4e9b\u540d\u4e3a\u8840\u7ba1\u751f\u6210\u6291\u5236\u5242\u7684\u9776\u5411\u836f\u4f1a\u963b\u6b62\u8fd9\u79cd\u65b0\u7684\u8840\u7ba1\u751f\u957f\uff1a<\/p>\n

\u8d1d\u4f10\u5355\u6297\uff08Bevacizumab\uff0cAvastin\uff09<\/span><\/p>\n

\u7528\u4e8e\u6cbb\u7597\u665a\u671fNSCLC\u3002\u5b83\u662f\u4e00\u79cd\u5355\u514b\u9686\u6297\u4f53\uff08\u4e00\u79cd\u5408\u6210\u7684\u7279\u5b9a\u514d\u75ab\u7cfb\u7edf\u86cb\u767d\uff09\uff0c\u9776\u5411\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u8fd9\u79cd\u5e2e\u52a9\u65b0\u8840\u7ba1\u5f62\u6210\u7684\u86cb\u767d\u8d28\u3002\u8fd9\u79cd\u836f\u901a\u5e38\u4e0e\u5316\u7597\u4e00\u8d77\u4f7f\u7528\u3002\u7136\u540e\uff0c\u5982\u679c\u764c\u75c7\u60a3\u8005\u5e94\u7b54\u53cd\u5e94\u826f\u597d\uff0c\u53ef\u4ee5\u505c\u6b62\u5316\u7597\u5e76\u4e14\u53ea\u7ed9\u4e88\u8d1d\u4f10\u5355\u6297\u76f4\u5230\u764c\u75c7\u518d\u6b21\u5f00\u59cb\u751f\u957f\u3002<\/p>\n

\u96f7\u83ab\u82a6\u5355\u6297\uff08Ramucirumab\uff0cCyramza\uff09<\/span><\/p>\n

\u4e5f\u53ef\u7528\u4e8e\u6cbb\u7597\u665a\u671fNSCLC\u3002\u8be5\u836f\u7269\u901a\u8fc7\u7ed3\u5408\u5230\u79f0\u4e3a\u53d7\u4f53\u7684\u7ec6\u80de\u86cb\u767d\u4e0a\u800c\u53d1\u6325\u4f5c\u7528\uff0c\u662f\u9776\u5411VEGF\u53d7\u4f53\u7684\u5355\u514b\u9686\u6297\u4f53\u3002\u8fd9\u6709\u52a9\u4e8e\u963b\u6b62\u65b0\u8840\u7ba1\u7684\u5f62\u6210\u3002\u8fd9\u79cd\u836f\u7269\u901a\u5e38\u5728\u5176\u4ed6\u836f\u7269\u8010\u836f\u540e\u7ed9\u4e88\uff0c\u901a\u5e38\u4e0e\u5316\u7597\u8054\u5408\u6cbb\u7597\u3002<\/p>\n

VEGF\u6291\u5236\u5242\u5e38\u89c1\u526f\u4f5c\u7528<\/span><\/p>\n

\u00d8 \u9ad8\u8840\u538b<\/p>\n

\u00d8 \u75b2\u5026\uff08\u75b2\u52b3\uff09<\/p>\n

\u00d8 \u6d41\u8840<\/p>\n

\u00d8 \u767d\u7ec6\u80de\u8ba1\u6570\u4f4e\uff08\u611f\u67d3\u98ce\u9669\u589e\u52a0\uff09<\/p>\n

\u00d8 \u5934\u75db<\/p>\n

\u00d8 \u53e3\u8154\u6e83\u75a1<\/p>\n

\u00d8 \u98df\u6b32\u4e0d\u632f<\/p>\n

\u00d8 \u8179\u6cfb<\/p>\n

\u7f55\u89c1\u526f\u4f5c\u7528<\/span><\/p>\n

\u7f55\u89c1\u4f46\u53ef\u80fd\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u53ef\u80fd\u5305\u62ec\u8840\u6813\uff0c\u4e25\u91cd\u51fa\u8840\uff0c\u80a0\u9053\u7a7f\u5b54\uff0c\u5fc3\u810f\u95ee\u9898\u548c\u4f24\u53e3\u6108\u5408\u7f13\u6162\u3002\u5982\u679c\u53d1\u751f\u80a0\u9053\u7a7f\u5b54\uff0c\u5219\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u611f\u67d3\uff0c\u5e76\u4e14\u53ef\u80fd\u9700\u8981\u624b\u672f\u6765\u5904\u7406\u3002<\/p>\n

\u7531\u4e8e\u51fa\u8840\u7684\u98ce\u9669\uff0c\u8fd9\u4e9b\u836f\u7269\u901a\u5e38\u4e0d\u7528\u4e8e\u54b3\u8840\u6216\u670d\u7528\u8840\u6db2\u7a00\u91ca\u5242\u836f\u7269\u7684\u60a3\u8005\u3002\u5bf9\u4e8e\u9cde\u72b6\u7ec6\u80de\u578bNSCLC\u60a3\u8005\uff0c\u80ba\u90e8\u4e25\u91cd\u51fa\u8840\u7684\u98ce\u9669\u8f83\u9ad8\uff0c\u8fd9\u5c31\u662f\u4e3a\u4ec0\u4e48\u5927\u591a\u6570\u73b0\u884c\u6307\u5357\u4e0d\u5efa\u8bae\u5728\u60a3\u6709\u6b64\u7c7b\u80ba\u764c\u7684\u4eba\u7fa4\u4e2d\u4f7f\u7528\u8d1d\u4f10\u5355\u6297\u3002<\/p>\n

2 EGFR<\/p>\n

\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u662f\u7ec6\u80de\u8868\u9762\u7684\u86cb\u767d\u8d28\uff0c\u6709\u52a9\u4e8e\u7ec6\u80de\u751f\u957f\u548c\u5206\u88c2\u3002NSCLC\u7ec6\u80de\u901a\u5e38\u8fc7\u8868\u8fbeEGFR\uff0c\u8fd9\u4f7f\u5f97\u764c\u7ec6\u80de\u751f\u957f\u5f97\u66f4\u5feb\u3002EGFR\u6291\u5236\u5242\u7c7b\u836f\u7269\u53ef\u963b\u65adEGFR\u7684\u4fe1\u53f7\uff0c\u963b\u6b62\u7ec6\u80de\u751f\u957f\uff0c\u8fd9\u7c7b\u7528\u4e8e\u6cbb\u7597NSCLC\u7684\u9776\u5411\u836f\u975e\u5e38\u591a\u3002<\/p>\n

\u7528\u4e8eNSCLC\u7684EGFR\u6291\u5236\u5242<\/span><\/p>\n

\u00d8 \u5384\u6d1b\u66ff\u5c3c(Erlotinib \uff0c\u7279\u7f57\u51efTarceva)<\/p>\n

\u00d8 \u963f\u6cd5\u66ff\u5c3c(Afatinib\uff0c\u5409\u6cf0\u745eGilotrif)<\/p>\n

\u00d8 \u5409\u975e\u66ff\u5c3c(Gefitinib \uff0c\u6613\u745e\u6c99Iressa)<\/p>\n

\u00d8 \u5965\u5e0c\u66ff\u5c3c(Osimertinib\uff0c\u6cf0\u745e\u6c99Tagrisso)<\/p>\n

\u8fd9\u4e9b\u836f\u7269\u53ef\u5355\u72ec\u4f7f\u7528\uff08\u65e0\u5316\u7597\uff09\u4f5c\u4e3aEGFR\u57fa\u56e0\u7a81\u53d8\u7684\u665a\u671fNSCLC\u7684\u9996\u6b21\u6cbb\u7597\u3002\u8fd9\u4e9b\u5728\u5973\u6027\u548c\u672a\u5438\u70df\u7684\u4eba\u7fa4\u4e2d\u66f4\u4e3a\u5e38\u89c1\u3002\u5982\u679c\u5316\u7597\u4e0d\u8d77\u4f5c\u7528\uff0c\u5384\u6d1b\u66ff\u5c3c\u4e5f\u53ef\u4ee5\u7528\u4e8e\u6ca1\u6709\u8fd9\u4e9b\u7a81\u53d8\u7684\u665a\u671fNSCLC\u3002\u6240\u6709\u8fd9\u4e9b\u836f\u7269\u90fd\u662f\u53e3\u670d\u7c7b\u836f\u4e38\uff0c\u4e0d\u7528\u6ce8\u5c04\uff0c\u7528\u836f\u975e\u5e38\u65b9\u4fbf\u3002<\/p>\n

\u5965\u5e0c\u66ff\u5c3c\u9776\u5411\u5177\u6709T790M\u7a81\u53d8\u7684\u7ec6\u80de<\/span><\/p>\n

EGFR\u6291\u5236\u5242\u901a\u5e38\u53ef\u4f7f\u80bf\u7624\u7f29\u5c0f\u6570\u6708\u6216\u66f4\u957f\u65f6\u95f4\u3002\u4f46\u6700\u7ec8\u5927\u591a\u6570\u4eba\u7531\u4e8e\u53d1\u751f\u8010\u836f\uff0c\u8fd9\u4e9b\u836f\u7269\u4e0d\u518d\u9002\u7528\uff0c\u901a\u5e38\u662f\u56e0\u4e3a\u764c\u7ec6\u80de\u4f1a\u5728EGFR\u57fa\u56e0\u4e2d\u53d1\u751f\u53e6\u4e00\u79cd\u7a81\u53d8\uff0c\u5373T790M\u7a81\u53d8\u3002 Osimertinib\uff08Tagrisso\uff09\u662f\u4e00\u79cdEGFR\u6291\u5236\u5242\uff0c\u53ef\u4e13\u95e8\u5bf9\u6297\u5177\u6709T790M\u7a81\u53d8\u7684\u764c\u7ec6\u80de\u3002\u5f53EGFR\u6291\u5236\u5242\u53d1\u751f\u8010\u836f\uff0c\u4e3a\u4e86\u89e3\u60a3\u8005\u662f\u5426\u5df2\u53d1\u751fT790M\u7a81\u53d8\u65f6\uff0c\u533b\u751f\u73b0\u5728\u901a\u5e38\u4f1a\u8fdb\u884c\u53e6\u4e00\u6b21\u80bf\u7624\u6d3b\u68c0\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u6765\u786e\u5b9a\u3002<\/p>\n

EGFR\u6291\u5236\u5242\u7528\u4e8e\u9cde\u72b6NSCLC<\/span><\/p>\n

\u8010\u59a5\u73e0\u5355\u6297\uff08Necitumumab\uff0cPortrazza\uff09\u662f\u4e00\u79cd\u9488\u5bf9EGFR\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u4e00\u79cd\u91cd\u7ec4\u4eba\u6e90\u6027lgG1\u5355\u514b\u9686\u6297\u4f53\uff0c\u4e0e\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53(EGFR)\u7ed3\u5408\uff0c\u4ece\u800c\u963b\u65adEGFR\u4e0e\u5176\u914d\u4f53\u7684\u7ed3\u5408\u3002\u5b83\u53ef\u4ee5\u4e0e\u5316\u7597\u4e00\u8d77\u7528\u4f5c\u665a\u671f\u9cde\u72b6\u7ec6\u80deNSCLC\u60a3\u8005\u7684\u9996\u6b21\u6cbb\u7597\u3002\u8be5\u836f\u7269\u662f\u901a\u8fc7\u9759\u8109\u8f93\u6ce8\u7ed9\u836f\uff08IV\uff09\u3002<\/p>\n

EGFR\u6291\u5236\u5242\u5e38\u89c1\u526f\u4f5c\u7528<\/span><\/p>\n

\u00d8 \u76ae\u80a4\u95ee\u9898<\/p>\n

\u00d8 \u8179\u6cfb<\/p>\n

\u00d8 \u53e3\u8154\u6e83\u75a1<\/p>\n

\u00d8 \u98df\u6b32\u4e0d\u632f<\/p>\n

**\u76ae\u80a4\u95ee\u9898\u53ef\u80fd\u5305\u62ec\u9762\u90e8\u548c\u80f8\u90e8\u51fa\u73b0\u75e4\u75ae\u6837\u76ae\u75b9\uff0c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u4f1a\u5bfc\u81f4\u76ae\u80a4\u611f\u67d3\uff0c\u4e25\u91cd\u7684\u60c5\u51b5\u9700\u8981\u627e\u533b\u751f\u4f1a\u7ed9\u4e88\u5bf9\u75c7\u5904\u7406\u3002<\/p>\n

\u7f55\u89c1\u526f\u4f5c\u7528<\/span><\/p>\n

\u8fd9\u4e9b\u836f\u7269\u4e5f\u53ef\u5f15\u8d77\u66f4\u4e25\u91cd\u4f46\u4e0d\u592a\u5e38\u89c1\u7684\u526f\u4f5c\u7528\u3002\u4f8b\u5982\uff0c\u8010\u59a5\u73e0\u5355\u6297\u53ef\u4ee5\u964d\u4f4e\u8840\u6db2\u4e2d\u67d0\u4e9b\u77ff\u7269\u8d28\u7684\u542b\u91cf\uff0c\u4f1a\u5f71\u54cd\u5fc3\u5f8b\uff0c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u53ef\u80fd\u4f1a\u5371\u53ca\u751f\u547d\u3002<\/p>\n

3 ALK<\/p>\n

\u5927\u7ea65\uff05\u7684NSCLC\u4f1a\u53d1\u751fALK\u57fa\u56e0\u91cd\u6392\u3002\u8fd9\u79cd\u53d8\u5316\u6700\u5e38\u89c1\u4e8e\u60a3\u6709\u817a\u764c\u4e9a\u578b\u7684\u975e\u5438\u70df\u8005\uff08\u6216\u8f7b\u5ea6\u5438\u70df\u8005\uff09\u3002 ALK\u57fa\u56e0\u91cd\u6392\u4ea7\u751f\u5f02\u5e38\u7684ALK\u86cb\u767d\uff0c\u5bfc\u81f4\u7ec6\u80de\u751f\u957f\u548c\u6269\u6563\u3002<\/p>\n

\u9776\u5411ALK\u86cb\u767d\u5f02\u5e38\u7684\u836f\u7269\uff1a<\/span><\/p>\n

\u00d8 \u514b\u5511\u66ff\u5c3c(Crizotinib\uff0cXalkori)<\/p>\n

\u00d8 \u8272\u745e\u66ff\u5c3c(Ceritinib\uff0cZykadia)<\/p>\n

\u00d8 \u827e\u4e50\u66ff\u5c3c(Alectinib\uff0cAlecensa)<\/p>\n

\u00d8 \u5e03\u52a0\u66ff\u5c3c(Brigatinib\uff0cAlunbrig)<\/p>\n

\u8fd9\u4e9b\u836f\u7269\u901a\u5e38\u53ef\u4ee5\u7f29\u5c0f\u80ba\u764c\u60a3\u8005ALK\u57fa\u56e0\u53d1\u751f\u7a81\u53d8\u7684\u80bf\u7624\u3002\u867d\u7136\u4ed6\u4eec\u53ef\u4ee5\u5728\u5316\u7597\u8010\u836f\u540e\u4e5f\u6709\u6548\uff0c\u4f46\u5728ALK\u57fa\u56e0\u91cd\u6392\u7684\u60a3\u8005\u4e2d\u7ecf\u5e38\u4f7f\u7528\u8fd9\u7c7b\u836f\u7269\u4ee3\u66ff\u5316\u7597\u3002\u8fd9\u4e9b\u836f\u7269\u4e5f\u53ef\u4ee5\u7528\u4e8e\u6cbb\u7597ROS1\u57fa\u56e0\u7a81\u53d8\u7684\u60a3\u8005\u3002\u6240\u6709\u8fd9\u4e9b\u836f\u7269\u90fd\u662f\u53e3\u670d\u7c7b\u836f\u4e38\u3002<\/p>\n

ALK\u6291\u5236\u5242\u5e38\u89c1\u526f\u4f5c\u7528<\/span><\/p>\n

\u6076\u5fc3<\/p>\n

\u5455\u5410<\/p>\n

\u8179\u6cfb\u4fbf<\/p>\n

\u79d8\u75b2\u52b3<\/p>\n

\u89c6\u529b\u53d8\u5dee<\/p>\n

\u7f55\u89c1\u526f\u4f5c\u7528<\/span><\/p>\n

\u4e00\u4e9b\u526f\u4f5c\u7528\u53ef\u80fd\u5f88\u4e25\u91cd\uff0c\u4f8b\u5982\u767d\u7ec6\u80de\u8ba1\u6570\u4f4e\uff0c\u80ba\u90e8\u708e\u75c7\uff0c\u809d\u635f\u4f24\u548c\u5fc3\u5f8b\u95ee\u9898\uff0c\u51fa\u73b0\u4e25\u91cd\u526f\u4f5c\u7528\u4e00\u5b9a\u8981\u53bb\u533b\u9662\u5c31\u8bca\u3002<\/p>\n

4 BRAF<\/p>\n

\u5728\u4e00\u4e9bNSCLC\u60a3\u8005\u4e2d\uff0c\u4e5f\u4f1a\u53d1\u751fBRAF\u57fa\u56e0\u7a81\u53d8\u3002\u5177\u6709\u8fd9\u4e9b\u53d8\u5316\u7684\u7ec6\u80de\u5c06\u4ea7\u751f\u6539\u53d8\u7684BRAF\u86cb\u767d\u8d28\uff0c\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u3002\u9776\u5411BRAF\u86cb\u767d\u8d28\u836f\u7269\u5305\u62ec\uff1a<\/p>\n

\u8fbe\u62c9\u975e\u5c3c\uff08Dabrafenib\uff0cTafinlar\uff09<\/span>\u662f\u4e00\u79cdBRAF\u6291\u5236\u5242\u7c7b\u836f\u7269\uff0c\u53ef\u76f4\u63a5\u653b\u51fbBRAF\u86cb\u767d\u3002<\/p>\n

\u66f2\u7f8e\u66ff\u5c3c\uff08Trametinib\uff0cMekinist\uff09<\/span>\u88ab\u79f0\u4e3aMEK\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u5b83\u653b\u51fb\u76f8\u5173\u7684MEK\u86cb\u767d\u3002<\/p>\n

\u5982\u679c\u60a3\u8005\u53d1\u751fBRAF\u57fa\u56e0\u6539\u53d8\uff0c\u8fd9\u4e24\u4e2a\u836f\u7269\u53ef\u4ee5\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027NSCLC\u3002\u8fd9\u4e9b\u836f\u7269\u7684\u5242\u578b\u4e3a\u836f\u7247\u6216\u80f6\u56ca\u3002<\/p>\n

BRAF\u6291\u5236\u5242\u5e38\u89c1\u526f\u4f5c\u7528<\/span><\/p>\n

\u76ae\u80a4\u589e\u539a\uff0c\u76ae\u75b9\uff0c\u7619\u75d2\uff0c\u5bf9\u592a\u9633\u7684\u654f\u611f\uff0c\u5934\u75db\uff0c\u53d1\u70e7\uff0c\u5173\u8282\u75bc\u75db\uff0c\u75b2\u52b3\uff0c\u8131\u53d1\uff0c\u6076\u5fc3\u548c\u8179\u6cfb\u3002<\/p>\n

\u7f55\u89c1\u526f\u4f5c\u7528<\/span><\/p>\n

\u53ef\u80fd\u5305\u62ec\u51fa\u8840\uff0c\u5fc3\u5f8b\u95ee\u9898\uff0c\u809d\u810f\u6216\u80be\u810f\u95ee\u9898\uff0c\u80ba\u90e8\u95ee\u9898\uff0c\u4e25\u91cd\u7684\u8fc7\u654f\u53cd\u5e94\uff0c\u4e25\u91cd\u7684\u76ae\u80a4\u6216\u773c\u90e8\u95ee\u9898\uff0c\u4ee5\u53ca\u8840\u7cd6\u6c34\u5e73\u5347\u9ad8\u3002\u4e00\u4e9b\u63a5\u53d7\u6b64\u7c7b\u836f\u7269\u6cbb\u7597\u7684\u4eba\u4f1a\u60a3\u76ae\u80a4\u764c\uff0c\u7279\u522b\u662f\u9cde\u72b6\u76ae\u80a4\u764c\u3002\u5728\u6cbb\u7597\u671f\u95f4\u548c\u4e4b\u540e\u51e0\u4e2a\u6708\u9700\u8981\u7ecf\u5e38\u590d\u67e5\u76ae\u80a4\u3002\u5982\u679c\u60a8\u53d1\u73b0\u76ae\u80a4\u6709\u4efb\u4f55\u65b0\u7684\u751f\u957f\u6216\u5f02\u5e38\u533a\u57df\uff0c\u60a8\u4e5f\u5e94\u7acb\u5373\u544a\u77e5\u533b\u751f\u3002<\/p>\n

\u57fa\u56e0\u68c0\u6d4b\u9700\u51c6\u5907<\/span><\/p>\n

\u505a\u4e86\u624b\u672f\u6216\u8005\u75c5\u7076\u7a7f\u523a\u7684\u60a3\u8005\u53ea\u9700\u8981\u53bb\u75c5\u7406\u79d1\u501f\u4e00\u4e9b\u5207\u7247\u51fa\u6765\u5c31\u53ef\u4ee5\u5b8c\u6210\u57fa\u56e0\u68c0\u6d4b\u4e86\uff0c\u5982\u679c\u6ca1\u6709\u505a\u624b\u672f\u6216\u8005\u624b\u672f\u65f6\u95f4\u591a\u4e8e\u4e00\u5e74\u7684\u60a3\u8005\u60f3\u8981\u57fa\u56e0\u68c0\u6d4b\u53ef\u4ee5\u9009\u62e9\u8840\u6db2\u68c0\u6d4b\uff0c\u62bd\u53d610ml\u5916\u5468\u8840\u5373\u53ef\u5b8c\u6210\u5168\u57fa\u56e0\u68c0\u6d4b\u3002<\/p>\n

\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u9996\u5148\u8981\u6709\u6211\u4eec\u8eab\u4e0a\u7684\u57fa\u56e0\uff0c\u505a\u8fc7\u624b\u672f\u6216\u8005\u505a\u8fc7\u80a0\u955c\u80c3\u955c\u7b49\u7684\u4eba\uff0c\u5728\u75c5\u7406\u79d1\u90fd\u4f1a\u6709\u4ee5\u8721\u5757\u7684\u5f62\u5f0f\u4fdd\u5b58\u7684\u4ece\u60a3\u8005\u8eab\u4e0a\u53d6\u7684\u201c\u8089\u201d\uff0c\u5982\u679c\u5b9e\u5728\u6ca1\u6709\u80fd\u7528\u4e8e\u68c0\u6d4b\u7684\u201c\u8089\u201d\uff0c\u90a3\u62bd\u4e00\u7ba1\u8840\u3001\u7559\u53d6\u553e\u6db2\u6216\u8005\u7ec6\u80de\u6d82\u7247\u90fd\u662f\u53ef\u4ee5\u7684\uff08\u67d0\u4e9b\u7279\u6b8a\u60c5\u51b5\u4e0b\uff09\uff0c\u8fd9\u4e9b\u68c0\u6750\u91cc\u9762\u5c31\u5305\u542b\u4e86\u6211\u4eec\u7684\u57fa\u56e0\u3002<\/p>\n

\u75c5\u7406\u533b\u751f\u62ff\u5230\u8fd9\u4e9b\u68c0\u6750\u540e\u4f1a\u8fdb\u884c\u57fa\u56e0\u7684\u63d0\u53d6\uff0c\u53bb\u9664\u68c0\u6750\u4e2d\u4e00\u4e9b\u5176\u4ed6\u7684\u6210\u5206\uff08\u4f8b\u5982\u86cb\u767d\u8d28\u3001\u8102\u80aa\u3001\u7cd6\u7c7b\u7b49\uff09\uff0c\u6700\u540e\u53ea\u5269\u4e0b\u6211\u4eec\u7684\u57fa\u56e0\uff0c\u7136\u540e\u628a\u63d0\u53d6\u5230\u7684\u57fa\u56e0\u6eb6\u89e3\u5728\u4e13\u7528\u7684\u6db2\u4f53\u91cc\uff0c\u5e76\u5728\u8d85\u4f4e\u6e29\u73af\u5883\u4e2d\u4fdd\u5b58\uff08-80\u2103\uff09\uff0c\u53ef\u4ee5\u4fdd\u8bc1\u5728\u76f8\u5f53\u957f\u7684\u65f6\u95f4\u5185\u4e0d\u4f1a\u4f7f\u63d0\u53d6\u51fa\u6765\u7684\u57fa\u56e0\u53d8\u8d28\u3002\u53ef\u4ee5\u8bf4\uff0c\u63d0\u53d6\u8fd9\u4e00\u6b65\u57fa\u672c\u4e0a\u662f\u505a\u57fa\u56e0\u68c0\u6d4b\u7684\u201c\u5fc5\u7ecf\u4e4b\u8def\u201d\u3002<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

\u56fe\u6ce8\uff1a\u6837\u672c\u5c31\u88ab\u4fdd\u5b58\u5728\u8fd9\u6837\u7684\u51b0\u7bb1\u91cc<\/p>\n

\u63a5\u4e0b\u6765\u75c5\u7406\u533b\u751f\u4f1a\u600e\u4e48\u505a\u5462\uff1f\u8fd9\u5177\u4f53\u8981\u770b\u60a3\u8005\u7684\u4e34\u5e8a\u533b\u751f\u5728\u75c5\u7406\u68c0\u67e5\u7533\u8bf7\u5355\u4e0a\u63d0\u51fa\u7684\u662f\u4ec0\u4e48\u57fa\u56e0\u7684\u68c0\u6d4b\uff0c\u800c\u4e0d\u540c\u7684\u57fa\u56e0\u53c8\u6709\u4e0d\u540c\u7684\u68c0\u6d4b\u624b\u6bb5\uff0c\u4e3b\u8981\u6709\u4ee5\u4e0b\u51e0\u79cd\uff1a1\u3001\u8367\u5149\u5b9a\u91cf\uff0c2\u3001\u4e00\u4ee3\u57fa\u56e0\u6d4b\u5e8f\uff0c3\u3001\u4e8c\u4ee3\u57fa\u56e0\u6d4b\u5e8f\uff0c4\u3001\u8367\u5149\u539f\u4f4d\u6742\u4ea4\uff08\u4ee5\u4e0b\u7b80\u79f0FISH\uff09\u7b49\u6280\u672f\u5e73\u53f0\uff0c\u4e0b\u9762\u5c06\u9488\u5bf9\u5404\u4e2a\u5e73\u53f0\u7ed3\u5408\u5b9e\u9645\u60c5\u51b5\u8c08\u8c08\u5728\u75c5\u7406\u79d1\u7684\u5e94\u7528\u3002<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

01<\/span><\/p>\n

\u7b2c\u4e00\u4e2a\u5148\u8bf4\u8bf4\u8367\u5149\u5b9a\u91cf\u5e73\u53f0<\/span>\u7684\u539f\u7406\u3002\u8fd9\u4e2a\u5e73\u53f0\u6240\u4f7f\u7528\u7684\u673a\u5668\uff0c\u65e0\u8bba\u8fdb\u53e3\u7684\u8fd8\u662f\u56fd\u4ea7\u7684\uff0c\u539f\u7406\u5927\u81f4\u76f8\u540c\uff0c\u5c31\u662f\u628a\u63d0\u53d6\u597d\u7684\u57fa\u56e0\u52a0\u5728\u914d\u5957\u4f7f\u7528\u7684\u8bd5\u5242\u91cc\u9762\uff0c\u5728\u7535\u8111\u4e0a\u8bbe\u7f6e\u597d\u7a0b\u5e8f\uff0c\u8ba9\u8367\u5149\u5b9a\u91cf\u5e73\u53f0\u7684\u673a\u5668\u8fd0\u884c\u8fd9\u4e2a\u7a0b\u5e8f\uff0c\u4ece\u800c\u8ba9\u6211\u4eec\u7684\u57fa\u56e0\u5728\u8bd5\u5242\u91cc\u9762\u8fdb\u884c\u6570\u4e07\u500d\u3001\u6570\u4ebf\u500d\u7684\u6269\u589e\uff08\u8ba9\u6211\u4eec\u7684\u57fa\u56e0\u53d8\u591a\uff09\uff0c\u5982\u679c\u6211\u4eec\u7684\u57fa\u56e0\u6709\u7a81\u53d8\u7684\u6210\u5206\uff0c\u5728\u8fd9\u4e2a\u6269\u589e\u7684\u8fc7\u7a0b\u4e2d\u5c31\u4f1a\u4f7f\u8bd5\u5242\u4e2d\u7684\u7279\u6b8a\u6210\u5206\u4f1a\u53d1\u51fa\u8367\u5149\u4fe1\u53f7\u4ece\u800c\u500d\u673a\u5668\u68c0\u6d4b\u5230\uff0c\u6574\u4e2a\u8fc7\u7a0b\u4e2d\u8367\u5149\u4fe1\u53f7\u662f\u5b9e\u65f6\u7d2f\u79ef\u7684\uff0c\u4ece\u800c\u8ba9\u6211\u4eec\u77e5\u9053\u8fd9\u4e2a\u57fa\u56e0\u662f\u4e0d\u662f\u7a81\u53d8\u7684\u3002\u6709\u8367\u5149\u4fe1\u53f7\u5373\u9633\u6027\uff0c\u53cd\u4e4b\u5219\u662f\u9634\u6027\u3002<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

\u8bf4\u5b8c\u4e86\u539f\u7406\uff0c\u63a5\u4e0b\u6765\u8bf4\u8bf4\u5177\u4f53\u7684\u5e94\u7528\u3002\u5728\u80ba\u764c\u4e2d\u5e38\u89c1\u7684\u81f4\u75c5\u57fa\u56e0\uff0c\u5982EGFR\u548cKRAS\uff0c\u548c\u5728\u67d0\u4e9b\u6076\u6027\u80bf\u7624\uff08\u5982\u6076\u6027\u9ed1\u8272\u7d20\u7624\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u7532\u72b6\u817a\u764c\u7b49\uff09\u4e2d\u5e38\u89c1\u7684\u81f4\u75c5\u57fa\u56e0BRAF\uff0c\u57fa\u672c\u4e0a\u5c31\u662f\u7528\u8fd9\u4e2a\u5e73\u53f0\u6765\u5b9e\u73b0\u68c0\u6d4b\u7684\u3002\u4e0a\u9762\u63d0\u5230\u4e86\u548c\u8fd9\u4e2a\u5e73\u53f0\u914d\u5957\u4f7f\u7528\u7684\u662f\u4e00\u4e9b\u8bd5\u5242\uff0c\u8fd9\u4e9b\u914d\u5957\u4f7f\u7528\u7684\u8bd5\u5242\u5c31\u51b3\u5b9a\u4e86\u53ef\u4ee5\u5728\u8fd9\u4e2a\u5e73\u53f0\u4e0a\u80fd\u68c0\u6d4b\u54ea\u4e9b\u57fa\u56e0\uff0c\u901a\u5e38\u914d\u5957\u4f7f\u7528\u7684\u67d0\u4e00\u79cd\u8bd5\u5242\u53ea\u80fd\u68c0\u6d4b\u67d0\u4e2a\u57fa\u56e0\uff0c\u4e5f\u5c31\u662f\u8bf4\u8bd5\u5242\u548c\u57fa\u56e0\u901a\u5e38\u662f\u4e00\u4e00\u5bf9\u5e94\u7684\u5173\u7cfb\u3002<\/p>\n

02<\/span><\/p>\n

\u7b2c\u4e8c\u4e2a\u6765\u8bf4\u8bf4\u4e00\u4ee3\u6d4b\u5e8f\u5e73\u53f0<\/span>\u3002\u6211\u4eec\u7684\u57fa\u56e0\u662f\u7531\u56db\u79cd\u4e0d\u540c\u7684\u5316\u5b66\u5206\u5b50\u7ec4\u6210\uff0c\u5b83\u4eec\u6309\u7167\u4e00\u5b9a\u7684\u987a\u5e8f\u6392\u5217\u5c31\u7ec4\u6210\u4e86\u6211\u4eec\u7684\u57fa\u56e0\u3002\u4e00\u4ee3\u6d4b\u5e8f\u5e73\u53f0\uff0c\u987e\u540d\u601d\u4e49\uff0c\u5c31\u662f\u628a\u57fa\u56e0\u91cc\u9762\u7ec4\u6210\u7684\u56db\u79cd\u4e0d\u540c\u7684\u5316\u5b66\u6210\u5206\u89e3\u8bfb\u51fa\u6765\u3002\u5728\u8fd9\u4e2a\u5e73\u53f0\u4e0a\u8fdb\u884c\u7684\u68c0\u6d4b\u4e3b\u8981\u662f\u6dcb\u5df4\u7624\u7ec6\u80de\u57fa\u56e0\u91cd\u6392\u3002<\/p>\n

\u6dcb\u5df4\u7ec6\u80de\u7684\u57fa\u672c\u7279\u5f81\u4e4b\u4e00\uff0c\u5373B\u7ec6\u80de\u4e2dIg\u57fa\u56e0\u548cT\u7ec6\u80de\u4e2d\u7684TCR\u57fa\u56e0\u7684\u91cd\u6392\u3002\u57fa\u56e0\u91cd\u6392\u6307\u7684\u662f\u4e0d\u540c\u7684\u6dcb\u5df4\u7ec6\u80de\u7684Ig\u6216\u8005TCR\u7247\u6bb5\u5728\u7ec6\u80de\u5206\u5316\u8fc7\u7a0b\u4e2d\u53d1\u751f\u7684\u91cd\u65b0\u6392\u5217\u7ec4\u5408\u3002\u6b63\u5e38\u6dcb\u5df4\u7ec6\u80de\u672a\u53d7\u4efb\u4f55\u523a\u6fc0\u60c5\u51b5\u4e0b\uff0c\u5176\u57fa\u56e0\u91cd\u6392\u662f\u968f\u673a\u7684\uff0c\u7ec6\u80de\u8868\u73b0\u4e3a\u591a\u5bb6\u65cf\u548c\u591a\u514b\u9686\u6027\uff0c\u5177\u6709\u53d1\u6325\u5404\u79cd\u7ec6\u80de\u514d\u75ab\u4f5c\u7528\u7684\u6f5c\u80fd\u3002<\/p>\n

\u800c\u5728\u6dcb\u5df4\u7624\u53d1\u751f\u8fc7\u7a0b\u4e2d\uff0c\u5728\u80bf\u7624\u7279\u5f02\u6027\u6297\u4f53\u6216\u80bf\u7624\u76f8\u5173\u6297\u539f\u523a\u6fc0\u4e0b\uff0c\u6dcb\u5df4\u7ec6\u80de\u67d0\u4e00\u4e2a\u6216\u51e0\u4e2aTCR\u6216Ig\u57fa\u56e0\u5bb6\u65cf\u4f1a\u53d1\u751f\u9488\u5bf9\u6027\u548c\u9009\u62e9\u6027\u91cd\u6392\uff0c\u5bfc\u81f4TCR\u6216Ig\u57fa\u56e0\u5355\u514b\u9686\u6027\u8868\u8fbe\uff0c\u4f7f\u6dcb\u5df4\u7ec6\u80de\u5448\u73b0\u4e3a\u514b\u9686\u6027\u589e\u6b96\uff0c\u5bfc\u81f4\u5728\u6dcb\u5df4\u7ed3\uff0c\u5916\u5468\u8840\u6216\u8005\u9aa8\u9ad3\u7ec6\u80de\u4e2d\u51fa\u73b01\u4e2a\u62162\u4e2a\u4e3b\u8981\u6dcb\u5df4\u7ec6\u80de\u514b\u9686\uff0c\u4e3a\u5355\u514b\u9686\u6027\u3002TCR\u548cIg\u57fa\u56e0\u5bb6\u65cf\u7684\u5355\u514b\u9686\u91cd\u6392\u662f\u6dcb\u5df4\u7624\u7ec6\u80de\u7fa4\u7684\u91cd\u8981\u7279\u5f81\uff0c\u7528\u4e8e\u8f85\u52a9\u8bca\u65ad\u6dcb\u5df4\u7624\u3002<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n

03<\/span><\/p>\n

\u7b2c\u4e09\u4e2a\u6765\u8bf4\u8bf4\u4e8c\u4ee3\u6d4b\u5e8f\u5e73\u53f0<\/span>\u3002\u4e8c\u4ee3\u6d4b\u5e8f\u5e73\u53f0\u662f\u5728\u4e00\u4ee3\u6d4b\u5e8f\u5e73\u53f0\u4e0a\u8fdb\u5316\u800c\u6765\u7684\u4e00\u79cd\u6d4b\u5e8f\u6280\u672f\u3002\u4e8c\u4ee3\u6d4b\u5e8f\u6280\u672f\u5e73\u53f0\u6bd4\u4e00\u4ee3\u6d4b\u5e8f\u6280\u672f\u5e73\u53f0\u7684\u901a\u91cf\uff08\u6bcf\u6b21\u80fd\u68c0\u6d4b\u7684\u57fa\u56e0\u4e2a\u6570\uff09\u5927\u4e86\u5f88\u591a\uff0c\u7075\u654f\u5ea6\u9ad8\uff0c\u800c\u4e14\u6210\u672c\u4e5f\u76f8\u5bf9\u4f4e\u5ec9\uff0c\u4ece\u800c\u5f97\u4ee5\u53d1\u5c55\u5e76\u88ab\u5b9e\u9645\u5e94\u7528\u3002\u539f\u7406\u548c\u4e00\u4ee3\u6d4b\u5e8f\u6280\u672f\u5e73\u53f0\u4e00\u6837\uff0c\u90fd\u662f\u5c06\u57fa\u56e0\u7684\u56db\u79cd\u5316\u5b66\u6210\u5206\u7684\u6392\u5217\u8fdb\u884c\u8bfb\u53d6\uff0c\u4e0d\u540c\u7684\u662f\uff0c\u4e8c\u4ee3\u6d4b\u5e8f\u5e73\u53f0\u9700\u8981\u5148\u5c06\u63d0\u53d6\u7684\u57fa\u56e0\u901a\u8fc7\u4e13\u7528\u8bd5\u5242\u8fdb\u884c\u51e0\u6b65\u7279\u6b8a\u7684\u5904\u7406\uff0c\u7136\u540e\u518d\u5728\u6d4b\u5e8f\u7684\u673a\u5668\u4e0a\u8fdb\u884c\u6d4b\u5e8f\u53cd\u5e94\uff0c\u518d\u7ecf\u8fc7\u6570\u636e\u5206\u6790\u5f97\u5230\u6211\u4eec\u60f3\u8981\u7684\u5e8f\u5217\u4fe1\u606f\u3002<\/p>\n

\u76ee\u524d\uff0c\u5728\u9776\u5411\u6cbb\u7597\u3001\u7528\u836f\u7597\u6548\u76d1\u63a7\u548c\u9057\u4f20\u7b5b\u67e5\u7b49\u65b9\u9762\uff0c\u4e8c\u4ee3\u6d4b\u5e8f\u6280\u672f\u5e73\u53f0\u53d1\u6325\u7740\u91cd\u8981\u7684\u4f5c\u7528\u3002\u968f\u7740\u9776\u5411\u6cbb\u7597\u836f\u7269\u7684\u7814\u53d1\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u9776\u5411\u836f\u7269\u88ab\u5f00\u53d1\u51fa\u6765\uff0c\u8fd9\u4e9b\u7528\u4e8e\u9776\u5411\u6cbb\u7597\u7684\u836f\u7269\u90fd\u5bf9\u5e94\u7740\u4e00\u4e9b\u53d7\u76ca\u4eba\u7fa4\uff0c\u800c\u8fd9\u4e9b\u53d7\u76ca\u4eba\u7fa4\u5c31\u662f\u4ee5\u57fa\u56e0\u6765\u8fdb\u884c\u533a\u5206\u7684\u3002\u663e\u7136\u4e8c\u4ee3\u6d4b\u5e8f\u6280\u672f\u5e73\u53f0\u7684\u5927\u901a\u91cf\u4e00\u6b21\u5c31\u53ef\u4ee5\u5c06\u5f88\u591a\u60a3\u8005\u8fdb\u884c\u6709\u6548\u7684\u7b5b\u9009\uff0c\u4ece\u800c\u786e\u5b9a\u75c5\u4eba\u9002\u5408\u7528\u4ec0\u4e48\u836f\u7269\u8fdb\u884c\u6cbb\u7597\uff0c\u4ece\u800c\u8f85\u52a9\u4e34\u5e8a\u533b\u751f\u5236\u5b9a\u5408\u7406\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n

04<\/span><\/p>\n

\u6700\u540e\u8bf4\u8bf4FISH<\/span>\u3002\u8fd9\u4e2a\u6280\u672f\u5e73\u53f0\u6bd4\u8f83\u7279\u6b8a\uff0c\u5b83\u4e0d\u9700\u8981\u8fdb\u884c\u57fa\u56e0\u7684\u63d0\u53d6\uff0c\u800c\u662f\u76f4\u63a5\u5728\u767d\u7247\u4e0a\u8fdb\u884c\u68c0\u6d4b\u3002\u4f17\u6240\u5468\u77e5\uff0c\u6211\u4eec\u7684\u57fa\u56e0\u662f\u53cc\u87ba\u65cb\u7ed3\u6784\u7684\uff0c\u5728\u5ba4\u6e29\u4e0b\u662f\u5f88\u7a33\u5b9a\u7684\uff0c\u4f46\u662f\u5728\u9ad8\u6e29\uff0895\u2103\u5de6\u53f3\uff09\u4e0b\u5bb9\u6613\u201c\u4e00\u5206\u4e3a\u4e8c\u201d\uff0c\u5f62\u6210\u4e24\u6761\u5355\u94fe\uff0c\u6e29\u5ea6\u964d\u4f4e\u540e\u53c8\u4f1a\u201c\u5408\u4e8c\u4e3a\u4e00\u201d\uff0c\u91cd\u65b0\u53d8\u6210\u53cc\u87ba\u65cb\u7ed3\u6784\uff0c\u800cFISH\u5e73\u53f0\u6700\u6838\u5fc3\u7684\u90e8\u5206\u5c31\u662f\u88ab\u8367\u5149\u6807\u8bb0\u4e86\u7684\u4e00\u6bb5\u548c\u76ee\u6807\u57fa\u56e0\u533a\u6bb5\u76f8\u5339\u914d\u7684\u63a2\u9488\uff0c\u5f53\u8fbe\u5230\u9ad8\u6e29\u540e\uff0c\u53cc\u87ba\u65cb\u7ed3\u6784\u201c\u4e00\u5206\u4e3a\u4e8c\u201d\uff0c\u5728\u6e29\u5ea6\u964d\u4f4e\u7684\u8fc7\u7a0b\u4e2d\u63a2\u9488\u5c31\u4f1a\u548c\u5b83\u6240\u5339\u914d\u7684\u57fa\u56e0\u8fdb\u884c\u6742\u4ea4\uff0c\u5f62\u6210\u7ed3\u5408\u4f53\uff0c\u7136\u540e\u628a\u5b83\u4eec\u653e\u5728\u8367\u5149\u663e\u5fae\u955c\u4e0b\u8fdb\u884c\u7ec6\u80de\u8ba1\u6570\uff0c\u5c06\u663e\u5fae\u955c\u4e0b\u8ba1\u6570\u9633\u6027\u7ec6\u80de\u4e2a\u6570\u548c\u603b\u8ba1\u7ec6\u80de\u4e2a\u6570\uff0c\u4e24\u503c\u76f8\u9664\uff0c\u5f97\u5230\u4e00\u4e2a\u767e\u5206\u6570\u7684\u6bd4\u503c\uff0c\u5728\u5c06\u8fd9\u4e2a\u6bd4\u503c\u548c\u5b9e\u9a8c\u6240\u7528\u7684\u63a2\u9488\u5bf9\u5e94\u7684\u9608\u503c\uff08\u9634\u6027\u548c\u9633\u6027\u7684\u5206\u754c\u7ebf\uff09\u8fdb\u884c\u6bd4\u8f83\uff0c\u5c0f\u4e8e\u9608\u503c\u5373\u9634\u6027\uff0c\u5927\u4e8e\u9608\u503c\u5373\u9633\u6027\u3002<\/p>\n

FISH\u6280\u672f\u5e73\u53f0\u5728\u80ba\u817a\u764c\u3001\u4e73\u817a\u764c\u3001\u8111\u80bf\u7624\u3001\u8f6f\u7ec4\u7ec7\u8089\u7624\u3001\u8840\u6db2\u5b66\u4e2d\u5df2\u5f97\u5230\u5e7f\u6cdb\u5e94\u7528\uff0c\u5176\u662f\u80ba\u817a\u764c\u548c\u4e73\u817a\u764c\u3002\u80ba\u817a\u764c\u4e2d\u67095%-8%\u7684\u60a3\u8005\u4e2d\u5b58\u5728ALK\u878d\u5408\u57fa\u56e0\uff0c\u643a\u5e26ALK\u878d\u5408\u57fa\u56e0\u7684\u60a3\u8005\u53ef\u4ee5\u4ece\u9776\u5411\u836f\u7269\u514b\u5511\u66ff\u5c3c\u7684\u6cbb\u7597\u4e2d\u53d7\u76ca\u3002\u4e0b\u56fe\u5de6\u4fa7\u90e8\u5206\u7ea2\u70b9\u548c\u7eff\u70b9\u5206\u5f00\u4e86\uff0c\u8bf4\u660eALK\u57fa\u56e0\u53d1\u751f\u4e86\u65ad\u88c2\u4e0e\u522b\u7684\u57fa\u56e0\u8fdb\u884c\u4e86\u878d\u5408\uff0c\u663e\u793a\u4e3a\u9633\u6027\u7ed3\u679c\uff1b\u800c\u53f3\u4fa7\u56fe\u7247\u7ea2\u70b9\u548c\u7eff\u70b9\u672a\u5206\u5f00\uff0c\u8bf4\u660eALK\u57fa\u56e0\u6ca1\u6709\u53d1\u751f\u65ad\u88c2\uff0c\u663e\u793a\u4e3a\u9634\u6027\u7ed3\u679c\u3002<\/p>\n

\"\u80bf\u7624\u9776\u5411\u836f\u7269\u4e0e\u57fa\u56e0\u68c0\u6d4b\"<\/p>\n


<\/p>\n

\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/span>
<\/p>\n

<\/span><\/a>\u52a0\u5165\u57fa\u56e0\u4ff1\u4e50\u90e8  \u83b7\u53d6\u6700\u65b0\u884c\u4e1a\u62a5\u544a<\/span><\/a>
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