{"id":50345,"date":"2018-09-23T01:00:00","date_gmt":"2018-09-26T02:08:18","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e5%85%ab%e4%b8%aa%e5%89%8d%e6%b2%bf%e5%9c%a8%e7%a0%94%e6%96%b0%e8%8d%af%e4%b8%b4%e5%ba%8a%e6%95%b0%e6%8d%ae%e5%85%a8%e7%90%83%e9%a6%96%e5%8f%91%ef%bc%8c%e8%8e%b7%e6%8a%95%e8%b5%84%e6%9c%ba%e6%9e%84\/"},"modified":"2018-09-26T10:08:23","modified_gmt":"2018-09-26T02:08:23","slug":"%e5%85%ab%e4%b8%aa%e5%89%8d%e6%b2%bf%e5%9c%a8%e7%a0%94%e6%96%b0%e8%8d%af%e4%b8%b4%e5%ba%8a%e6%95%b0%e6%8d%ae%e5%85%a8%e7%90%83%e9%a6%96%e5%8f%91%ef%bc%8c%e8%8e%b7%e6%8a%95%e8%b5%84%e6%9c%ba%e6%9e%84","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/50345\/","title":{"rendered":"\u516b\u4e2a\u524d\u6cbf\u5728\u7814\u65b0\u836f\u4e34\u5e8a\u6570\u636e\u5168\u7403\u9996\u53d1\uff0c\u83b7\u6295\u8d44\u673a\u6784\u9ad8\u5ea6\u5173\u6ce8"},"content":{"rendered":"
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2018\u5e749\u670818\u65e5\uff0c\u5728\u5907\u53d7\u77a9\u76ee\u7684\u7b2c\u4e09\u5c4a\u201c\u4e2d\u56fd\u533b\u836f\u521b\u65b0\u4e0e\u6295\u8d44\u5927\u4f1a\u201d\u4e34\u5e8a\u6570\u636e\u9996\u53d1\u4e13\u573a\uff0c\u516b\u4e2a\u5728\u7814\u65b0\u836f\u8fdb\u884c\u4e86\u5168\u7403\u9996\u53d1\uff0c\u9879\u76ee\u6db5\u76d6\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u708e\u3001\u8111\u80f6\u8d28\u7624\u3001\u665a\u671f\u8f6f\u7ec4\u7ec7\u8089\u7624\u3001\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\u3001\u6dcb\u5df4\u7624\u3001\u809d\u7ec6\u80de\u764c\u3001\u9547\u75db\u3001HIV\u7b49\u6cbb\u7597\u9886\u57df\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n

\u4e2d\u56fd\u533b\u836f\u521b\u65b0\u4fc3\u8fdb\u4f1a\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u4e2d\u56fd\u836f\u4fc3\u4f1a\u201d\uff092016-2017\u5e74\u5ea6\u4f1a\u957f\u3001\u8d1d\u8fbe\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u8463\u4e8b\u957f\u517cCEO\u4e01\u5217\u660e\u535a\u58eb\uff0c\u4e2d\u56fd\u836f\u4fc3\u4f1a\u521b\u65b0\u7814\u53d1\u670d\u52a1\u4e13\u4e1a\u59d4\u5458\u4f1a\u4e3b\u4efb\u59d4\u5458\u3001\u7f14\u8109\u751f\u7269\u533b\u836f\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\u8463\u4e8b\u957f\u517cCEO\u8c2d\u51cc\u5b9e\u535a\u58eb\u4f5c\u4e3a\u4e3b\u6301\u4eba\u5206\u522b\u4e3b\u6301\u4e0a\u3001\u4e0b\u534a\u573a\u7684\u6570\u636e\u9996\u53d1\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u516b\u4e2a\u524d\u6cbf\u5728\u7814\u65b0\u836f\u4e34\u5e8a\u6570\u636e\u5168\u7403\u9996\u53d1\uff0c\u83b7\u6295\u8d44\u673a\u6784\u9ad8\u5ea6\u5173\u6ce8\"
<\/strong><\/p>\n

\u4e3b\u6301\u4eba\uff1a\u4e01\u5217\u660e\u535a\u58eb\uff08\u5de6\uff09\u548c\u8c2d\u51cc\u5b9e\u535a\u58eb\uff08\u53f3\uff09<\/span><\/strong><\/p>\n


<\/p>\n

\u516b\u4e2a\u9879\u76ee\u5747\u805a\u7126\u4e34\u5e8a\u5177\u6709\u8feb\u5207\u9700\u6c42\u3001\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u624b\u6bb5\u7684\u75be\u75c5\u9886\u57df\uff0c\u53d1\u5e03\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u6d89\u53caI\u671f\u3001I&IIa\u671f\u3001II\/IIb\u671f\u4ee5\u53caIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002<\/span><\/p>\n


<\/span><\/p>\n

\uff08\u4e00\uff09\u56db\u4e2a\u53d1\u5e03I\u671f\u6216I\/IIa\u671f\u7684\u9879\u76ee\uff0c\u5747\u663e\u793a\u51fa\u6bd4\u5404\u81ea\u9886\u57df\u76f8\u5173\u540c\u7c7b\u6cbb\u7597\u836f\u7269\u5177\u6709\u66f4\u597d\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\u4f18\u52bf<\/span><\/strong><\/p>\n


<\/span><\/strong><\/p>\n

1\u3001\u514b\u670d\u683c\u5217\u536b\u8010\u836f\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5242HQP1351\u4e34\u5e8a\u5b89\u5168\u6027\u4e0e\u521d\u6b65\u7597\u6548 I\u671f\u7ed3\u679c <\/span><\/strong><\/p>\n


<\/span><\/p>\n

\"\u516b\u4e2a\u524d\u6cbf\u5728\u7814\u65b0\u836f\u4e34\u5e8a\u6570\u636e\u5168\u7403\u9996\u53d1\uff0c\u83b7\u6295\u8d44\u673a\u6784\u9ad8\u5ea6\u5173\u6ce8\"
<\/strong><\/p>\n

\u6c47\u62a5\u4eba\uff1a\u4e9a\u76db\u533b\u836f\u8463\u4e8b\u957f\u517cCEO\u6768\u5927\u4fca<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08CML\uff09\u662f\u6211\u56fd\u6162\u6027\u767d\u8840\u75c5\u7684\u4e3b\u8981\u75c5\u79cd\uff0c\u7ea6\u5360\u6162\u6027\u767d\u8840\u75c5\u768470%\uff0c\u4e3b\u8981\u89c1\u4e8e\u6210\u5e74\u4eba\u3002HQP1351\u662f\u4e9a\u76db\u533b\u836f\u5728\u7814\u76841\u7c7b\u65b0\u836f\uff0c\u4e3a\u56fd\u5185\u9996\u4e2a\u9ad8\u6548\u7b2c\u4e09\u4ee3Bcr-Abl\u9776\u5411\u8010\u836fCML\u7684\u53e3\u670d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u4e13\u4e3a\u9776\u5411Bcr-Abl\uff08\u5305\u62ec\u91ce\u751f\u578b\uff09\u548cT315I\u7a81\u53d8\u8bbe\u8ba1\uff0c\u7528\u4e8e\u6cbb\u7597\u5bf9\u4f0a\u9a6c\u66ff\u5c3c\u4ea7\u751f\u8010\u836f\u6027\u7684CML\u60a3\u8005\uff0c\u5305\u62ec\u643a\u5e26T315I\u7a81\u53d8\u7684\u60a3\u8005\u3002HQP1351\u76ee\u524d\u6b63\u5728CML\u548cGIST\u4e2d\u5f00\u5c55I\/II\u4e34\u5e8a\u7814\u7a76\u3002\u622a\u81f3 2018\u5e746\u670830\u65e5\uff0c\u5728CML\u4e2d\u53ef\u83b7\u5f97\u7684\u521d\u6b65\u4e34\u5e8a\u7ed3\u679c\u663e\u793a\uff0cHQP1351\u5bf9\u4e8e\u5176\u4ed6 TKI \u8010\u836f\u7684 CML \u60a3\u8005\u7597\u6548\u663e\u8457\u3002CML\u6162\u6027\u671f (CP-CML) \u7684\u60a3\u8005\uff0c48\u540d (100%) \u53ef\u8bc4\u4f30\u60a3\u8005\u8fbe\u5230\u5b8c\u5168\u8840\u6db2\u5b66\u53cd\u5e94(CHR)\uff0c56%\u8fbe\u5230\u4e3b\u8981\u7ec6\u80de\u9057\u4f20\u5b66\u53cd\u5e94\uff0c\u800c18%\u8fbe\u5230\u4e3b\u8981\/\u5b8c\u5168\u5206\u5b50\u5b66\u53cd\u5e94\u3002\u5728\u5177\u6709 T315I \u7a81\u53d8\u7684 CP- CML \u60a3\u8005\u4e2d\uff0c100%\u8fbe\u5230\u5b8c\u5168\u8840\u6db2\u5b66\u53cd\u5e94\uff0c62%\u8fbe\u5230\u4e3b\u8981\u7ec6\u80de\u9057\u4f20\u5b66\u53cd\u5e94\uff0c26%\u8fbe\u5230\u4e3b\u8981\/\u5b8c\u5168\u5206\u5b50\u5b66\u53cd\u5e94\uff0c\u60a3\u8005\u75c5\u60c5\u7f13\u89e3\u6548\u679c\u6301\u4e45\u3002CML\u52a0\u901f\u671f(AP-CML) \u7684\u60a3\u8005\uff0c58%\u8fbe\u5230CHR\uff0c\u800c 43%\u8fbe\u5230\u4e3b\u8981\u7ec6\u80de\u9057\u4f20\u5b66\u53cd\u5e94\u3002\u4e0e\u56fd\u5916\u5df2\u4e0a\u5e02\u7684\u4e09\u4ee3\u683c\u5217\u536b\u76f8\u6bd4\uff0cHQP1351\u663e\u793a\u51fa\u826f\u597d\u7684\u6709\u6548\u6027\uff0c\u66f4\u4f18\u7684\u5b89\u5168\u6027\uff0c\u6709\u6f5c\u529b\u6210\u4e3a\u683c\u5217\u536b\u8010\u836fCML\u6cbb\u7597\u7684\u201cbest-in-class\u201d\u836f\u7269\u3002<\/span><\/p>\n


<\/span><\/p>\n

2\u3001\u7ecf\u809d\u52a8\u8109\u7ed9\u836f\u5bf9\u809d\u7ec6\u80de\u764c\u7cbe\u51c6\u6cbb\u7597\u7684\u5168\u7403\u65b0\u5c0f\u5206\u5b50\u836f\u7269LT001\u7684I\u671f\u548cIIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c <\/span><\/strong><\/p>\n


<\/span><\/p>\n

\"\u516b\u4e2a\u524d\u6cbf\u5728\u7814\u65b0\u836f\u4e34\u5e8a\u6570\u636e\u5168\u7403\u9996\u53d1\uff0c\u83b7\u6295\u8d44\u673a\u6784\u9ad8\u5ea6\u5173\u6ce8\"
<\/strong><\/p>\n

\u6c47\u62a5\u4eba\uff1a\u676d\u5dde\u6cf0\u6cca\u533b\u836f\u4e2d\u56fd\u533b\u5b66\u6267\u884c\u5b98\u65bd\u6d77\u5764<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u4e2d\u56fd\u662f\u809d\u764c\u5927\u56fd\uff0c\u6bcf\u5206\u949f\u7ea6\u6709\u4e00\u4e2a\u75c5\u4eba\u6b7b\u4e8e\u809d\u764c\u3002\u809d\u52a8\u8109\u6813\u585e\u5408\u5e76\u5316\u7597\uff08TACE\uff09\u4f5c\u4e3a\u65e0\u6cd5\u8fdb\u884c\u624b\u672f\u7684\u4e2d\u671f\u809d\u764c\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6cd5\uff0c90%\uff08\u6bcf\u5e7440\u4e07\uff09\u7684\u809d\u764c\u75c5\u4eba\u91c7\u53d6TACE\uff0c\u80bf\u7624\u5b8c\u5168\u7f13\u89e3\u7387CR\u4e00\u822c\u4ec5\u4e3a10%-30%\u3002TACE\u7597\u6cd5\u4e0d\u5c3d\u4eba\u610f\u7684\u539f\u56e0\u5728\u4e8e\u6813\u585e\u9020\u6210\u80bf\u7624\u7f3a\u6c27\uff0c\u7f3a\u6c27\u8bf1\u5bfc\u809d\u80bf\u7624\u5e72\u7ec6\u80de\u7684\u6d3b\u5316\u589e\u6b96\uff0c\u589e\u52a0\u80bf\u7624\u518d\u53d1\u53ca\u6269\u6563\u7684\u673a\u4f1a\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u7ecf\u809d\u52a8\u8109\u6ce8\u5c04LT001\u540e\u518d\u884c\u809d\u52a8\u8109\u62f4\u585e\uff08TATE\uff09\u89e3\u51b3\u4e86TACE\u9762\u4e34\u7684\u95ee\u9898\u3002LT001\u5728\u7f3a\u6c27\u7684\u73af\u5883\u4e2d\u901a\u8fc7\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u4ea7\u751f\u5927\u91cf\u7684\u81ea\u7531\u57fa\uff0c\u4e0eDNA\u7ed3\u5408\u7834\u574fDNA\u548c\u7ec6\u80de\u5668\u800c\u6740\u6b7b\u80bf\u7624\uff08\u5e72\uff09\u7ec6\u80de\uff0c\u5bf9\u6b63\u5e38\u809d\u7ec4\u7ec7\u7ec6\u80de\u6ca1\u6709\u6740\u4f24\u4f5c\u7528\u3002<\/span><\/p>\n


<\/span><\/p>\n

TATE\u5728\u7f8e\u56fd\u5b8c\u6210\u4e86I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5171\u6cbb\u7597\u4e8627\u4f8b\u60a3\u8005\uff0824\u4f8b\u53ef\u8bc4\u4f30\u60a3\u8005\uff0c45%\u4e9a\u6d32\u4eba\uff09\uff0c62.5%\u7684\u75c5\u4eba\u8fbe\u5230\u4e86\u80bf\u7624\u5b8c\u5168\u574f\u6b7b\uff0c\u65e0\u80bf\u7624\u8fdb\u5c55\u671f\u7684\u4e2d\u4f4d\u6570\u4e3a12\u4e2a\u6708\u30022017\u5e745\u67088\u65e5\uff0cFDA \u5bf9I\u671f\u7ed3\u679c\u4e88\u4ee5\u80af\u5b9a\uff0c\u5982\u80fd\u5b8c\u6210134\u4e2a\u75c5\u4eba\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0cFDA\u5c06\u7ed9\u4e88LT001\u5feb\u901f\u5ba1\u8bc4\u8d44\u683c\u3002TATE\u6b63\u5728\u7f8e\u56fd\u5f00\u5c55IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5373\u8054\u5408anti-PD-1\u5355\u6297\u6cbb\u7597\u8fdb\u5c55\u6027\u665a\u671f\u809d\u764c\uff0c\u5171\u5165\u7ec43\u4f8b\u60a3\u8005\uff0c\u76ee\u524d\u4e24\u4f8b\u60a3\u8005\u809d\u764c\u80bf\u7624\u5168\u90e8\u574f\u6b7b\uff0c\u5904\u4e8e\u65e0\u80bf\u7624\u751f\u5b58\uff0c\u4e00\u4f8b\u60a3\u8005\u8fdb\u5c55\u60c5\u51b5\u6b63\u5728\u968f\u8bbf\u4e2d\u30022017\u5e747\u6708\uff0cCFDA\u5df2\u540c\u610fTATE\u5728\u4e2d\u56fd\u514d\u9664I\u671f\u4e34\u5e8a\uff0c\u76f4\u63a5\u8fdb\u884c200\u4eba\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5df2\u7ecf\u786e\u5b9a\u4e86PI, 16\u540d\u4e34\u5e8a\u7814\u7a76\u533b\u751f\u548c16\u5bb6\u533b\u7597\u5355\u4f4d\uff0c\u9884\u8ba12018\u5e7412\u67081\u65e5\u5f00\u59cb\u5165\u7ec4\u60a3\u8005\u3002<\/span><\/p>\n


<\/span><\/p>\n

3\u3001\u5929\u7136\u5c0f\u5206\u5b50\u521b\u65b0\u836f\u6ce8\u5c04\u7528\u7eff\u539f\u9178\u6cbb\u7597\u80f6\u8d28\u7624I\u671f\u4e34\u5e8a\u6570\u636e\u56de\u987e\u53ca\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5c55\u671b <\/span><\/strong><\/p>\n


<\/span><\/p>\n

\"\u516b\u4e2a\u524d\u6cbf\u5728\u7814\u65b0\u836f\u4e34\u5e8a\u6570\u636e\u5168\u7403\u9996\u53d1\uff0c\u83b7\u6295\u8d44\u673a\u6784\u9ad8\u5ea6\u5173\u6ce8\"
<\/strong><\/p>\n

\u6c47\u62a5\u4eba\uff1a\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5929\u575b\u533b\u9662\u4e3b\u4efb \u674e\u6587\u658c<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08GBM\uff09\u6076\u6027\u7a0b\u5ea6\u9ad8\uff0c\u73b0\u9636\u6bb5\u65e0\u6709\u6548\u6cbb\u7597\u836f\u7269\u3002\u7eff\u539f\u9178\uff08CHA\uff09\u662f\u56db\u5ddd\u4e5d\u7ae0\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u5f00\u53d1\u7684 1.2 \u7c7b\u5929\u7136\u5c0f\u5206\u5b50\u65b0\u836f\uff0c\u4e3b\u8981\u901a\u8fc7\u89e3\u9664LAG3\u5bf9\u514d\u75ab\u7ec6\u80de\u7684\u6291\u5236\u53d1\u6325\u5e7f\u8c31\u6297\u80bf\u7624\u7684\u4f5c\u7528\u3002\u6ce8\u5c04\u7528CHA\u6cbb\u7597\u7ecf\u6807\u51c6\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\u6027\u9ad8\u7ea7\u522b\u8111\u80f6\u8d28\u7624\u60a3\u8005\u7684 I \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e3b\u8981\u8003\u5bdf\u7eff\u539f\u9178\u7684\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u53ca\u521d\u6b65\u7684\u7597\u6548\u8bc4\u4ef7\uff1b\u5165\u7ec4\u60a3\u8005\u597d\u768426\u4f8b\uff08IV\u7ea721\u4f8b\uff0cIII\u7ea75\u4f8b\uff0c3\u4f8b\u63d0\u524d\u51fa\u7ec4\uff09\u3002I \u671f\u7ed3\u679c\u8868\u660e\uff0c\u7eff\u539f\u9178\u5b89\u5168\u6027\u826f\u597d\uff0c\u9664\u6ce8\u5c04\u90e8\u4f4d\u5c40\u90e8\u786c\u7ed3\u4e0d\u826f\u53cd\u5e94\u5916\uff0c\u65e0\u5176\u5b83\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u836f\u4ee3\u52a8\u529b\u5b66\u663e\u793a\uff0c\u7eff\u539f\u9178 t1\/2 \u4e3a 1-1.5 h\uff0c\u4ee3\u8c22\u5feb\uff0c\u65e0\u84c4\u79ef\u6bd2\u6027\u3002\u521d\u6b65\u7684\u7597\u6548\u8bc4\u4ef7\u7ed3\u679c\u559c\u4eba\uff0c1 \u4f8b CR\uff08\u5b8c\u5168\u7f13\u89e3\uff09\uff0c1 \u4f8b PR\uff08\u90e8\u5206\u7f13\u89e3\uff09\uff0c\u4e14\u6709\u6548\u5242\u91cf\u7ec4 IV \u7ea7\u8111\u80f6\u8d28\u7624\u60a3\u8005\u4e2d\u4f4d OS \u8fdc\u8d85\u5386\u53f2\u6570\u636e\uff0c\u8fbe\u5230 21.4 \u4e2a\u6708\uff0c\u80fd\u4e00\u5b9a\u7a0b\u5ea6\u89e3\u9664\u590d\u53d1\u6027GBM\u53d7\u8bd5\u8005\u51fa\u73b0\u7684TMZ\u8010\u836f\u73b0\u8c61\u3002CHA\u6cbb\u7597\u590d\u53d1\u6027GBM\u7684II\/III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9884\u8ba1\u4e3a\u968f\u673a\u3001\u5bf9\u7167\u3001\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u8bd5\u9a8c\uff0cOS\u4f5c\u4e3a\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff0c\u786e\u8bc1CHA\u6cbb\u7597\u590d\u53d1\u6027GBM\u7597\u6548\u540e\u5c06\u7533\u8bf7\u6709\u6761\u4ef6\u6279\u51c6\u4e0a\u5e02\u3002<\/span><\/p>\n


<\/span><\/p>\n

4\u3001\u7b2c\u4e09\u4ee3\u6297HIV\u975e\u6838\u82f7\u65b0\u836fACC007\u7684 I \u671f\u548c\u2161a\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c <\/span><\/strong><\/p>\n


<\/span><\/p>\n

\"\u516b\u4e2a\u524d\u6cbf\u5728\u7814\u65b0\u836f\u4e34\u5e8a\u6570\u636e\u5168\u7403\u9996\u53d1\uff0c\u83b7\u6295\u8d44\u673a\u6784\u9ad8\u5ea6\u5173\u6ce8\"
<\/strong><\/span><\/p>\n

\u6c47\u62a5\u4eba\uff1a\u6c5f\u82cf\u827e\u8fea\u836f\u4e1a\u526f\u603b\u88c1 \u6c88\u5c0f\u5b81<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

\u4e2d\u56fd\u662f\u827e\u6ecb\u75c5\u5927\u56fd\uff0c\u6309\u7167\u8054\u5408\u56fd\u827e\u6ecb\u75c5\u89c4\u5212\u7f72\u5173\u4e8e\u827e\u6ecb\u75c5\u57282020\u5e74\u8bca\u65ad90%\u3001\u6cbb\u759790%\u3001\u6cbb\u7597\u6709\u654890%\u7684\u76ee\u6807\uff0c\u4e2d\u56fd\u5728\u8bca\u65ad\u548c\u6cbb\u7597\u8986\u76d6\u4e0a\u8fd8\u6709\u5dee\u8ddd\uff0c\u6709\u7ea6\u4e09\u5206\u4e4b\u4e00\u7684\u611f\u67d3\u8005\u672a\u88ab\u53d1\u73b0\uff0c\u9632\u827e\u5de5\u4f5c\u4f9d\u7136\u4efb\u91cd\u9053\u8fdc\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4e00\u7c7b\u6297\u827e\u6ecb\u75c5\u65b0\u836fACC007\u662f\u6700\u5177\u6f5c\u529b\u7684\u7b2c\u4e09\u4ee3\u53e3\u670d\u975e\u6838\u82f7\u7c7bNNRTIs\u6291\u5236\u5242\uff0c2017\u5e74\u88ab\u5217\u5165\u56fd\u5bb6\u201c\u5341\u4e09\u4e94\u201d\u91cd\u5927\u65b0\u836f\u521b\u5236\u79d1\u6280\u91cd\u5927\u4e13\u9879\u3002\u76ee\u524d\u5df2\u5b8c\u6210I\u671f\u5065\u5eb7\u8005\u8bd5\u9a8c\u3001\u2161a\u671fHIV\u611f\u67d3\u8005\u8bd5\u9a8c\uff0c\u5728\u5b89\u5168\u6027\/\u4e0d\u826f\u4e8b\u4ef6\u65b9\u9762\u663e\u793a\u66f4\u5177\u4f18\u52bf\uff0c\u5bf9\u4e8e\u5355\u70b9\u8010\u836fWT\u3001K103N\u3001Y181C\u5177\u6709\u8f83\u597d\u6548\u679c\uff0c\u75c5\u6bd2\u8f7d\u91cf\u4e0b\u964d\u6307\u6807\u8d85\u51fa\u56fd\u9645\u516c\u8ba4\u7684\u6297\u827e\u6ecb\u75c5\u75c5\u6bd2\u6d3b\u6027\u8981\u6c42\uff1a\u7ecf\u8840\u6e05\u86cb\u767d\u8c03\u6574\u540e\uff0c\u5bf9HIV\u5177\u6709\u9ad8\u6548\u7684\u5f3a\u6291\u5236\u6d3b\u6027\uff1b\u5b89\u5168\u6027\u9ad8\uff0c\u5bf9\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u65e0\u5f71\u54cd\uff1a\u5065\u5eb7\u5fd7\u613f\u8005SAD\u548c7\u5929MAD\u7684PK\u7814\u7a76\u663e\u793a\uff0c\u5242\u91cf600mg qd\u8010\u53d7\u6027\u826f\u597d\uff0c\u6ca1\u6709\u4e0eEFV\u7c7b\u4f3c\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u526f\u4f5c\u7528, \u672a\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u548c\u5bfc\u81f4\u8131\u843d\u7684\u4e0d\u826f\u4e8b\u4ef6\uff1b\u7ed9\u836f\u9891\u7387\u4f4e\uff1a\u53e3\u670d150mg \u4e00\u5929\u4e00\u6b21\u53ef\u63d0\u4f9b\u6709\u6548\u5242\u91cf\uff1b\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u98ce\u9669\u4f4e\uff1a\u901a\u8fc7CYP2C19\u4ee3\u8c22\uff0c\u975eCYP3A4\u5e95\u7269\u3002<\/span><\/p>\n


<\/span><\/p>\n

ACC007\u7ecfCDE\u540c\u610f\u5f00\u5c55\u2162\u671f\u4e34\u5e8a\uff0c\u9884\u8ba12020\u5e74\u4f5c\u4e3a\u6cbb\u7597HIV\u7684\u4e00\u7ebf\u7528\u836f\u4e0a\u5e02\u3002ACC007\u8054\u54083TC\u548cTDF\u7684\u4e09\u5408\u4e00\u590d\u65b9\u5236\u5242ACC008\uff0c\u9884\u8ba12018\u5e74\u83b7\u6279\u4e34\u5e8a\uff0c\u5c06\u6210\u4e3a\u56fd\u5185\u9996\u4e2a\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u4e09\u8054\u590d\u65b9\u6297HIV\u65b0\u836f\u3002<\/span><\/p>\n


<\/span><\/p>\n

\uff08\u4e8c\uff09\u4e24\u4e2a\u53d1\u5e03II\u671f\/IIb\u671f\u6570\u636e\u7684\u9879\u76ee\u5728\u5404\u81ea\u6cbb\u7597\u9886\u57df\u586b\u8865\u4e34\u5e8a\u7a7a\u767d<\/span><\/strong><\/p>\n


<\/span><\/strong><\/p>\n

1\u3001\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d(NASH)\u65b0\u836fSNP-610\u7684\u5f00\u653e\u5f0f\u4eba\u4f53II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c <\/span><\/strong><\/p>\n


<\/span><\/p>\n

\"\u516b\u4e2a\u524d\u6cbf\u5728\u7814\u65b0\u836f\u4e34\u5e8a\u6570\u636e\u5168\u7403\u9996\u53d1\uff0c\u83b7\u6295\u8d44\u673a\u6784\u9ad8\u5ea6\u5173\u6ce8\"
<\/strong><\/p>\n

\u6c47\u62a5\u4eba\uff1a\u6b23\u8000\u751f\u533b\u8463\u4e8b\u957f\u517cCEO\u6731\u51ef\u6c11<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d(NASH)\u662f\u76ee\u524d\u666e\u904d\u53ca\u672a\u6765\u6700\u4e25\u91cd\u7684\u809d\u810f\u75be\u75c5\uff0c\u5168\u740375\u4ebf\u4eba\u4e2d\u6709\u5927\u7ea61.1-2.4\u4ebf\uff086%-13%\uff09\u7684\u4eba\u7f79\u60a3\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u3002NASH\u56e0\u81f4\u75c5\u673a\u5236\u590d\u6742\uff0c\u5355\u9776\u70b9\u836f\u7269\u96be\u594f\u6548\uff0c\u76ee\u524d\u4e16\u754c\u65e0\u6807\u51c6\u6cbb\u7597\u836f\u7269\uff0c\u9700\u957f\u671f\u6216\u7ec8\u751f\u6cbb\u7597\uff0c\u5bf9\u836f\u7269\u5b89\u5168\u6027\u8981\u6c42\u6781\u9ad8\uff0c\u6781\u5bcc\u6311\u6218\u6027\u3002<\/span><\/p>\n


<\/span><\/p>\n

NP-6\u7cfb\u5217\u662f\u5e02\u573a\u9996\u89c1\u6cbb\u7597NASH\u7684\u5168\u65b0\u5316\u5b66\u5b9e\u4f53\u53ca\u65b0\u7528\u9014\u65b0\u836f\u3002\u5b83\u5177\u6709\u201c\u591a\u6cbb\u7597\u9776\u70b9\u201d\u7279\u6027\uff0c\u6709\u591a\u91cd\u4f5c\u7528\u673a\u5236\uff1a\u53ef\u964d\u4f4e\u809d\u810f\u4e09\u9178\u7518\u6cb9\u8102\u5806\u79ef\u3001\u6291\u5236\u809d\u810fomega\u6c27\u5316\u76f8\u5173\u9176\u3001\u964d\u4f4e\u53d1\u708e\u6c27\u5316\u7269\u8d28\u53ca\u964d\u4f4e\u809d\u53d1\u708e\u7ea4\u7ef4\u5316\u7684\u8d8b\u5316\u56e0\u5b50CCL2\uff0c\u53ef\u9884\u9632\u548c\u6cbb\u7597NASH\u3002SNP\u7cfb\u5217\u662f\u6781\u4e3a\u5b89\u5168\u7684\u5c0f\u5206\u5b50\u5316\u5b66\u7269\uff0c\u5176\u4e2dSNP-610\uff0c\u5df2\u7ecfFDA\u6838\u51c6\u8fdb\u884c\u4e34\u5e8aII\u671f\uff0c\u5176\u5f00\u653e\u5f0fII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u83b7\u5f97\u6bd4\u56fd\u9645\u5176\u4ed6NASH\u5728\u7814\u836f\u7269\u66f4\u663e\u8457\u7684\u4eba\u4f53\u7597\u6548\u8bc1\u636e\u300217\u4f4d NASH\u75c5\u4eba\uff0c\u7ecf12\u5468\u6cbb\u7597\u540e\uff0c\u4e3b\u8981\u7597\u6548\u6307\u6807\u809d\u810f\u8c37\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176(ALT)\u663e\u8457\u964d\u4f4e\u8fbe-30.7\u00b133.7 U\/L (p=0.002)\u3002\u5176\u4ed6\u7597\u6548\u6307\u6807\u5982\u8c37\u8349\u8f6c\u6c28\u9176(AST)\u3001\u4e73\u9178\u8131\u6c22\u9176\uff08LDH\uff09\u3001\u8d8b\u5316\u56e0\u5b50CCL2\/CCL5\u3001Casepase-3\u3001\u7a7a\u8179\u8840\u7cd6\u503c\u7b49\uff0c\u4ea6\u7686\u663e\u8457\u964d\u4f4e\u3002<\/span><\/p>\n


<\/span><\/p>\n

2\u3001\u5f00\u542f\u9776\u5411\u6cbb\u7597\u665a\u671f\u8f6f\u7ec4\u7ec7\u8089\u7624\u65b0\u7bc7\u7ae0\u7684\u65b0\u836f\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c\uff08\u4f5c\u4e3a\u7f55\u89c1\u75c5\u7528\u836f\uff09IIb\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e <\/span><\/strong><\/p>\n


<\/span><\/p>\n

\"\u516b\u4e2a\u524d\u6cbf\u5728\u7814\u65b0\u836f\u4e34\u5e8a\u6570\u636e\u5168\u7403\u9996\u53d1\uff0c\u83b7\u6295\u8d44\u673a\u6784\u9ad8\u5ea6\u5173\u6ce8\"
<\/strong><\/p>\n

\u6c47\u62a5\u4eba\uff1a\u4e0a\u6d77\u5e02\u7b2c\u516d\u4eba\u6c11\u533b\u9662\u4e3b\u4efb\u59da\u9633<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u8f6f\u7ec4\u7ec7\u8089\u7624\u5177\u670919\u4e2a\u7ec4\u7ec7\u7c7b\u578b\u548c50\u4e2a\u4ee5\u4e0a\u7684\u4e0d\u540c\u4e9a\u578b\uff0c\u53d1\u75c5\u7387\u5927\u7ea6\u4e3a1.28 -1.72\/10\u4e07\uff0c\u5360\u6210\u4eba\u5168\u90e8\u6076\u6027\u80bf\u7624\u76840.73%-0.81%\uff0c\u5360<15\u5c81\u7684\u513f\u7ae5\u5168\u90e8\u6076\u6027\u80bf\u7624\u76846.5%\uff1b\u6309\u53d1\u75c5\u7387\u8ba1\u7b97\uff0c\u4e2d\u56fd\u6bcf\u5e74\u53d1\u75c5\u4eba\u7fa4\u8d85\u8fc73\u4e07\u4eba\u3002\u76ee\u524d\u5728\u4e2d\u56fd\uff0c\u5bf9\u4e8e\u665a\u671f\u8f6f\u7ec4\u7ec7\u8089\u7624\u7684\u4e00\u7ebf\u5316\u7597\u5931\u8d25\u540e\u7684\u60a3\u8005\uff0c\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u7f3a\u4e4f\u6807\u51c6\u7684\u6cbb\u7597\u65b9\u6848\uff08\u5316\u7597\u836f\u7269\uff09\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c\u662f\u4e00\u7c7b\u53e3\u670d\u3001\u65b0\u578b\u5c0f\u5206\u5b50\u591a\u9776\u70b9\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002\u4e0d\u4ec5\u62e5\u6709\u591a\u9776\u70b9\uff0c\u800c\u4e14\u5bf9\u8fd9\u4e9b\u9776\u70b9\u5747\u5177\u6709\u8f83\u5f3a\u7684\u6291\u5236\u6d3b\u6027\uff0c\u80fd\u6709\u6548\u6291\u5236VEGFR\u3001PDGFR\u3001FGFR\u3001c-Kit \u7b49\u6fc0\u9176\uff0c\u5177\u6709\u6291\u5236\u80bf\u7624\u8840\u7ba1\u751f\u6210\u548c\u80bf\u7624\u751f\u957f\u7684\u4f5c\u7528\uff0c\u5b89\u5168\u6027\u826f\u597d\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u76d0\u9178\u5b89\u7f57\u66ff\u5c3cIIa\u671f\u4e34\u5e8a\u7814\u7a76\uff08\u5165\u7ec4166\u4f8b\u60a3\u8005\uff09\u663e\u793a\uff0c\u6cbb\u759712\u5468\u7684\u75be\u75c5\u65e0\u8fdb\u5c55\u7387\uff08PFR\uff09\u4e3a68.42%\uff0c\u8fbe\u5230\u4e86\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff1b\u4e2d\u4f4d\u75be\u75c5\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a5.63\u4e2a\u6708\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4e3a12.33\u4e2a\u6708\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a12.65%\uff0c\u817a\u6ce1\u72b6\u8f6f\u7ec4\u7ec7\u8089\u7624\u7ec4\u7684ORR\u6700\u9ad8\u4e3a46.15%\u3002IIb\u671f\u4e34\u5e8a\u7814\u7a76\uff08\u5165\u7ec4233\u4f8b\u60a3\u8005\uff09\u8fbe\u5230\u4e86\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff1a\u5b89\u7f57\u66ff\u5c3c\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u5bf9\u6bd4\uff0c\u80fd\u663e\u8457\u5ef6\u957fPFS\u8fbe4.8\u4e2a\u6708\uff086.27 vs 1.47\u6708\uff0cp<0.0001\uff09\uff1b\u663e\u8457\u63d0\u9ad8ORR\uff0810.13% vs 1.33%\uff0cp=0.0145\uff09\u548c\u75be\u75c5\u63a7\u5236\u7387DCR\uff0855.7% vs 22.67%\uff0cp<0.0001\uff09\uff0c\u603b\u751f\u5b58\u671f\u7684\u6570\u636e\u5c1a\u672a\u6210\u719f\u3002\u5b89\u7f57\u66ff\u5c3c\u5bf9\u591a\u79cd\u8f6f\u7ec4\u7ec7\u8089\u7624\u4e9a\u578b\u6709\u6cbb\u7597\u6548\u679c\uff0c\u5c24\u5176\u662f\u6ed1\u819c\u8089\u7624\u3001\u5e73\u6ed1\u808c\u8089\u7624\u3001\u817a\u6ce1\u72b6\u8f6f\u7ec4\u7ec7\u8089\u7624\u3002\u5b89\u7f57\u66ff\u5c3c\u5c06\u6709\u671b\u586b\u8865\u665a\u671f\u8f6f\u7ec4\u7ec7\u8089\u7624\u4e8c\u7ebf\u6cbb\u7597\u7684\u7a7a\u767d\u3002<\/span><\/p>\n


<\/span><\/p>\n

\uff08\u4e09\uff09\u4e24\u4e2a\u53d1\u5e03III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9879\u76ee\uff0c\u4e00\u4e2a\u662f\u6709\u671b\u6210\u4e3a\u975e\u5417\u5561\u7c7b\u56fd\u9645\u9996\u4e2a\u9769\u547d\u6027\u9547\u75db\u836f\uff0c\u53e6\u4e00\u4e2a\u5c06\u6210\u4e3a\u6211\u56fd\u9996\u4e2a\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f<\/span><\/strong><\/p>\n


<\/span><\/p>\n

1\u3001\u4e00\u79cd\u9769\u547d\u6027\u7684\u9547\u75db\u5242\u2014\u2014\u6cb3\u8c5a\u6bd2\u7d20\u6ce8\u5c04\u6db2Halneuron\u2122\u7684\u7f8e\u56fd\u4e34\u5e8aIII\u671f\u6570\u636e <\/span><\/strong><\/p>\n


<\/span><\/p>\n

\"\u516b\u4e2a\u524d\u6cbf\u5728\u7814\u65b0\u836f\u4e34\u5e8a\u6570\u636e\u5168\u7403\u9996\u53d1\uff0c\u83b7\u6295\u8d44\u673a\u6784\u9ad8\u5ea6\u5173\u6ce8\"
<\/strong><\/p>\n

\u6c47\u62a5\u4eba\uff1aWEX\u836f\u4e1a\u6709\u9650\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98 Christopger C. Gallen<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u4ec5\u7f8e\u56fd\u5c31\u6709\u7ea680\u4e07\u7531\u5316\u7597\u5f15\u8d77\u7684\u795e\u7ecf\u6e90\u6027\u75bc\u75db\u75c5\u4eba\uff0c\u5728\u6b27\u76df\u3001\u65e5\u672c\u3001\u4e2d\u56fd\u548c\u5176\u4ed6\u56fd\u5bb6\u6709\u8d85\u8fc7200\u4e07\u7684\u76f8\u5173\u75c5\u4eba\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u75bc\u75db\u7684\u6b62\u75db\u836f\u4ea7\u751f\u591a\u79cd\u963f\u7247\u7c7b\u7684\u526f\u4f5c\u7528\uff0c\u60a3\u8005\u4e9f\u9700\u5927\u91cf\u7684\u65b0\u578b\u975e\u963f\u7247\u7c7b\u836f\u6cbb\u7597\u795e\u7ecf\u75c5\u7406\u6027\u548c\u4f24\u5bb3\u6027\u75bc\u75db\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u6cb3\u8c5a\u6bd2\u7d20\u6ce8\u5c04\u6db2Halneuron\u2122\u4ee5\u5176\u72ec\u7279\u7684\u4f5c\u7528\u673a\u5236\u4ea7\u751f\u975e\u51e1\u7684\u9547\u75db\u4f5c\u7528\uff0c\u7597\u6548\u4f18\u4e8e\u5176\u5b83\u9547\u75db\u836f\u3002\u5b83\u662f\u4e00\u79cd\u4ece\u6cb3\u8c5a\u9c7c\u4e2d\u63d0\u53d6\u7684\u6709\u6548\u5c0f\u5206\u5b50\uff0c\u7531\u4e8e\u5206\u5b50\u5e26\u7535\uff0c\u53ea\u963b\u65ad\u5916\u5468\u94a0\u901a\u9053Nav1.7\u3001Nav1.4 \uff08\u53ef\u80fd\u8fd8\u6709Nav1.6\uff09\uff0c\u4e0d\u80fd\u901a\u8fc7\u8840\u8111\u5c4f\u969c\u8fdb\u5165\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff1b\u963b\u65ad\u94a0\u901a\u9053Nav 1.7 \u5bf9\u51cf\u8f7b\u5404\u79cd\u7c7b\u578b\u7684\u75bc\u75db\u5177\u6709\u663e\u8457\u7684\u7597\u6548\u3002\u4e0d\u540c\u4e8e\u5df2\u4e0a\u5e02\u7684\u9547\u75db\u836f\uff0cHalneuron\u2122\u4ec5\u9700\u5f88\u5c0f\u7684\u4e34\u5e8a\u5242\u91cf\u5c31\u53ef\u4ea7\u751f\u5b89\u5168\u548c\u6709\u6548\u7684\u9547\u75db\u4f5c\u7528\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u6162\u6027\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u75bc\u75db\uff0c\u4f8b\u5982\u5316\u7597\u5f15\u8d77\u7684\u795e\u7ecf\u6e90\u6027\u75bc\u75db\uff08CINP\uff09\u548c\u764c\u75c7\u76f8\u5173\u75bc\u75db\uff08CRP\uff09\uff0c\u5728\u6162\u6027\u75bc\u75db\u6cbb\u7597\u4e2d\u5c06\u53d1\u751f\u9769\u547d\u6027\u4f5c\u7528\u3002\u76ee\u524d\u5df2\u5b8c\u6210\u4e8613\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5165\u7ec4531 \u4eba(\u75c5\u4eba\u548c\u5065\u5eb7\u53d7\u8bd5\u8005\uff09\uff0c\u60a3\u8005\u5305\u62ec 348 \u540d\u764c\u75c7\u60a3\u8005\u548c157\u540d\u63a5\u53d7\u8fc7\u5b89\u6170\u5242\u7684\u764c\u75c7\u60a3\u8005\uff0c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u4ec5\u9650\u4e8e\u6ce8\u5c04\u671f\uff08\u7b2c1\u5929\u81f3\u7b2c4\u5929\uff09\uff0c\u901a\u5e38\u4e3a\u53e3\u5468\u548c\u6307\u5c16\u8f7b\u5ea6\u9ebb\u6728\uff0c96%\u7684\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u8f7b\u5ea6-\u4e2d\u5ea6\uff0c\u4f46\u75bc\u75db\u7f13\u89e3\u8fdc\u8fdc\u8d85\u51fa\u6ce8\u5c04\u671f\u3002III\u671f\u4e34\u5e8a\u764c\u75c7\u75bc\u75db\u8bd5\u9a8c\u663e\u793a\uff0c\u5728\u670d\u7528\u6b63\u5e38\u963f\u7247\u5242\u91cf\u7684\u75c5\u4eba\u4e2d\uff0cHalneuronTM \u5728\u591a\u79cd\u7597\u6548\u7ec8\u70b9\u4ea7\u751f\u4e86\u5353\u8d8a\u7684\u7597\u6548\u3002<\/span><\/p>\n


<\/span><\/p>\n

2\u3001HLX01\u5229\u59a5\u6614\u5355\u6297\u6ce8\u5c04\u6db2III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e <\/span><\/strong><\/p>\n


<\/span><\/p>\n

\"\u516b\u4e2a\u524d\u6cbf\u5728\u7814\u65b0\u836f\u4e34\u5e8a\u6570\u636e\u5168\u7403\u9996\u53d1\uff0c\u83b7\u6295\u8d44\u673a\u6784\u9ad8\u5ea6\u5173\u6ce8\"
<\/strong><\/p>\n

\u6c47\u62a5\u4eba\uff1a\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u526f\u9662\u957f \u77f3\u8fdc\u51ef<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u7531\u4e8e\u76ee\u524d\u5df2\u4e0a\u5e02\u7684\u6cbb\u7597\u5404\u5927\u80bf\u7624\u9886\u57df\u7684\u751f\u7269\u6297\u4f53\u836f\u7269\u4ef7\u683c\u9ad8\u6602\uff0c\u60a3\u8005\u8d1f\u62c5\u4e25\u91cd\uff0c\u56e0\u6b64\u56fd\u5185\u7814\u53d1\u578b\u4f01\u4e1a\u4e3b\u8981\u805a\u7126\u516d\u5927\u91cd\u78c5\u5355\u514b\u9686\u6297\u4f53\/\u878d\u5408\u86cb\u767d\uff08\u5373\u4fee\u7f8e\u4e50\u3001\u8d6b\u8d5b\u6c40\u3001\u7c7b\u514b\u3001\u6069\u5229\u3001\u963f\u74e6\u65af\u6c40\u3001\u7f8e\u7f57\u534e\uff09\u5f00\u5c55\u751f\u7269\u7c7b\u4f3c\u836f\u7814\u53d1\uff0c\u8fd9\u4e9b\u6297\u4f53\u4e3b\u8981\u9776\u70b9\u4e3aTNF\u03b1\u3001HER2\u3001VEGF\u3001CD20\u7b49\u3002\u590d\u5b8f\u6c49\u9716\u5728\u7814\u7684HLX01\u662f1997\u5e74\u4e0a\u5e02\u7684CD20\u5355\u6297\u7f8e\u7f57\u534e\u7684\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u6309\u6cbb\u7597\u7528\u751f\u7269\u5236\u54c12\u7c7b\u6ce8\u518c\u7533\u62a5\uff0c\u662f\u4e00\u7ebf\u6cbb\u7597CD20\u9633\u6027\u5f25\u6f2b\u578b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u53ca\u6ee4\u6ce1\u578b\u6dcb\u5df4\u7624\u7684\u91d1\u6807\u51c6\u3002\u76ee\u524dHLX01\u5df2\u5b8c\u6210III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff1a\u7b26\u5408\u65b9\u6848\u96c6384\u4f8b\uff0c\u6700\u4f73\u7f13\u89e3\u7387\uff08ORR\uff0993.5%\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\uff08CR\uff0948.5%\uff0c\u90e8\u5206\u7f13\u89e3\u7387\uff08PR\uff0943.8%\uff1b\u4e0d\u826f\u53cd\u5e94\u5728\u53ef\u63a7\u8303\u56f4\u5185\uff1b\u8868\u660eHLX01\u5728\u6cbb\u7597CD20\u9633\u6027\u5f25\u6f2b\u578b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u521d\u6cbb\u60a3\u8005\u4e2d\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u7ec8\u70b9\u3001\u6b21\u8981\u7ec8\u70b9\u5747\u8fbe\u5230\u9884\u8bbe\u6807\u51c6\uff0c\u4e0e\u539f\u7814\u836f\u5728\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u65b9\u9762\u5747\u5177\u6709\u53ef\u6bd4\u6027\uff0c\u53ef\u671b\u6210\u4e3a\u4e2d\u56fd\u7b2c\u4e00\u4e2a\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u3002<\/span><\/p>\n


<\/p>\n

\u4e34\u5e8a\u6570\u636e\u5168\u7403\u9996\u53d1\u4e13\u573a\u5df2\u7ecf\u8fde\u7eed\u4e3e\u529e\u4e24\u5c4a\uff0c\u662f\u56fd\u5185\u9996\u521b\u7684\u4e13\u4e3a\u6295\u8d44\u673a\u6784\u6df1\u5165\u4e86\u89e3\u521b\u65b0\u9879\u76ee\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u7279\u8bbe\u7684\u4e00\u9879\u6d3b\u52a8\u3002\u5f80\u5c4a\u53d1\u8868\u7684\u4e00\u4e9b\u9879\u76ee\u5df2\u83b7\u673a\u6784\u5173\u6ce8\u6216\u8005\u6295\u8d44\u3002\u4eca\u5e74\u53d1\u5e03\u4e34\u5e8a\u6570\u636e\u7684\u516b\u4e2a\u9879\u76ee\u8f83\u5f80\u5e74\u66f4\u5177\u521b\u65b0\u6027\uff0c\u4e34\u5e8a\u6570\u636e\u7ed3\u679c\u66f4\u4f18\uff0c\u56e0\u6b64\u53d7\u5230\u4e86\u4e0e\u4f1a\u6295\u8d44\u53ca\u533b\u836f\u754c\u4e13\u4e1a\u4eba\u58eb\u7684\u5e7f\u6cdb\u5173\u6ce8\u548c\u8ffd\u6367\uff0c\u4e13\u573a\u53c2\u4f1a\u4ee3\u8868\u8d85\u8fc7\u4e24\u5343\u4eba\u3002\u663e\u793a\u51fa\u8be5\u4e13\u573a\u5728\u4fc3\u8fdb\u521b\u65b0\u4e0e\u6295\u8d44\u5408\u4f5c\u65b9\u9762\u80fd\u591f\u53d1\u6325\u4e25\u683c\u5148\u671f\u9074\u9009\u548c\u9ad8\u7aef\u5e73\u53f0\u7684\u91cd\u8981\u4f5c\u7528\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u516b\u4e2a\u524d\u6cbf\u5728\u7814\u65b0\u836f\u4e34\u5e8a\u6570\u636e\u5168\u7403\u9996\u53d1\uff0c\u83b7\u6295\u8d44\u673a\u6784\u9ad8\u5ea6\u5173\u6ce8\"
<\/strong><\/p>\n

\u62a5\u544a\u7ed3\u675f\u6c47\u62a5\u4eba\u88ab\u6295\u8d44\u673a\u6784\u4ee3\u8868\u201c\u56f4\u8ffd\u5835\u622a\u201d<\/span><\/strong><\/p>\n


<\/span><\/strong><\/p>\n

\"\u516b\u4e2a\u524d\u6cbf\u5728\u7814\u65b0\u836f\u4e34\u5e8a\u6570\u636e\u5168\u7403\u9996\u53d1\uff0c\u83b7\u6295\u8d44\u673a\u6784\u9ad8\u5ea6\u5173\u6ce8\"
<\/strong><\/p>\n

\u706b\u7206\u7684\u4e34\u5e8a\u9996\u53d1\u4e13\u573a\u4f1a\u573a<\/span><\/strong><\/p>\n

\n
\n
\n
\n
<\/p>\n
\n

End<\/p>\n<\/section>\n

<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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