{"id":50419,"date":"2018-09-21T01:00:00","date_gmt":"2018-09-26T02:08:54","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e9%a6%96%e4%b8%aa%ef%bc%81%e7%ba%b3%e7%b1%b3%e6%8a%80%e6%9c%af%e4%bb%8b%e5%85%a5%e6%8a%91%e7%99%8c%e5%9f%ba%e5%9b%a0%e5%9c%a8%e5%89%8d%e5%88%97%e8%85%ba%e7%99%8c%e4%b8%ad%e5%8f%96%e5%be%97%e7%aa%81\/"},"modified":"2018-09-26T10:08:56","modified_gmt":"2018-09-26T02:08:56","slug":"%e9%a6%96%e4%b8%aa%ef%bc%81%e7%ba%b3%e7%b1%b3%e6%8a%80%e6%9c%af%e4%bb%8b%e5%85%a5%e6%8a%91%e7%99%8c%e5%9f%ba%e5%9b%a0%e5%9c%a8%e5%89%8d%e5%88%97%e8%85%ba%e7%99%8c%e4%b8%ad%e5%8f%96%e5%be%97%e7%aa%81","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/50419\/","title":{"rendered":"\u9996\u4e2a\uff01\u7eb3\u7c73\u6280\u672f\u4ecb\u5165\u6291\u764c\u57fa\u56e0\u5728\u524d\u5217\u817a\u764c\u4e2d\u53d6\u5f97\u7a81\u7834\u8fdb\u5c55 | Nature\u5b50\u520a"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  class=\"\" style=\"font-size: 16px;white-space: normal;max-width: 100%;text-align: justify;background-color: rgb(255, 255, 255);letter-spacing: 0.476px;color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding: 0.8em;max-width: 100%;border-width: 1px 0.4em;border-style: solid;border-color: rgb(172, 29, 16);border-radius: 0.3em;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 0.476px;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u4f17\u6240\u5468\u77e5\uff0c\u6291\u764c\u57fa\u56e0PTEN\u548cP53\u7b49\u7684\u7a81\u53d8\u548c\u7f3a\u5931\u4f1a\u5bfc\u81f4\u764c\u75c7\u4e0d\u53d7\u6291\u5236\u5730\u751f\u957f\u3002\u9488\u5bf9\u76f8\u5173\u57fa\u56e0\u7a81\u53d8\u7684\u7814\u7a76\u6709\u5f88\u591a\uff0c\u800c\u9488\u5bf9\u764c\u75c7\u4e2d\u4e22\u5931\u7684\u86cb\u767d\u8d28\u7684\u7814\u7a76\u4e00\u76f4\u662f\u4e00\u4e2a\u6311\u6218\u3002\u8fd1\u65e5\uff0c\u603b\u90e8\u4f4d\u4e8e\u6ce2\u58eb\u987f\u7684\u4e00\u4e2a\u5408\u4f5c\u56e2\u961f\u5229\u7528\u7eb3\u7c73\u6280\u672f\u548c\u72ec\u7279\u7684mRNA\u7279\u6027\uff0c\u901a\u8fc7\u9776\u5411PTEN\u6291\u5236\u4e86\u524d\u5217\u817a\u764c\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u7684\u80bf\u7624\u751f\u957f\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><img class=\"\"     style=\"margin-top: 6px;margin-bottom: 6px;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537927735.jpg\" alt=\"\u9996\u4e2a\uff01\u7eb3\u7c73\u6280\u672f\u4ecb\u5165\u6291\u764c\u57fa\u56e0\u5728\u524d\u5217\u817a\u764c\u4e2d\u53d6\u5f97\u7a81\u7834\u8fdb\u5c55 | Nature\u5b50\u520a\" title=\"\u9996\u4e2a\uff01\u7eb3\u7c73\u6280\u672f\u4ecb\u5165\u6291\u764c\u57fa\u56e0\u5728\u524d\u5217\u817a\u764c\u4e2d\u53d6\u5f97\u7a81\u7834\u8fdb\u5c55 | Nature\u5b50\u520a\"  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><span style=\"color: rgb(136, 136, 136);font-size: 15px;\">DOI\uff1ahttps:\/\/doi.org\/10.1038\/s41551-018-0284-0<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e9\u670817\u65e5\u4ee5\u201cRestoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA\u201d\u4e3a\u9898\u53d1\u8868\u5728\u300aNature Biomedical Engineering\u300b\u6742\u5fd7\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u6211\u4eec\u7684\u65b9\u6cd5\u4ee3\u8868\u4e86\u7eb3\u7c73\u6280\u672f\u548c\u751f\u7269\u5b66\u7684\u878d\u5408\uff0c\u201d\u901a\u8baf\u4f5c\u8005\u4e4b\u4e00\u3001\u5e03\u5217\u6839\u548c\u5987\u5973\u533b\u9662\uff08BWH\uff09\u7eb3\u7c73\u533b\u5b66\u4e2d\u5fc3\u6559\u6388\u517c\u9ebb\u9189\u526f\u6559\u6388Jinjun Shi\u535a\u58eb\u8bf4\uff0c\u201c\u5728\u7ea6\u4e00\u534a\u7684\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u548c\u8bb8\u591a\u5176\u4ed6\u4eba\u7c7b\u764c\u75c7\u4e2d\u90fd\u53ef\u89c2\u5bdf\u5230PTEN\u57fa\u56e0\u7684\u4e22\u5931\u6216\u7a81\u53d8\uff0c\u4f46\u662f\u529f\u80fd\u6027PTEN\u7684\u91cd\u5efa\u88ab\u8bc1\u660e\u662f\u56f0\u96be\u7684\u3002\u800c\u6700\u65b0\u57fa\u4e8emRNA\u7684\u7eb3\u7c73\u6cbb\u7597\u7684\u6f5c\u5728\u5f71\u54cd\u5728\u4e8e\uff0c\u5b83<strong>\u4e3a\u764c\u75c7\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u7b56\u7565\uff0c\u5e76\u4e14\u53ef\u4ee5\u8865\u5145\u76ee\u524d\u53ef\u7528\u7684\u5982\u9776\u5411\u6291\u5236\u5242\u7b49\u6cbb\u7597\u65b9\u6cd5<\/strong>\u3002\u201d<\/span><\/p>\n<section class=\"\"  style=\"max-width: 100%;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin: 10px auto;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 3px;margin-left: 33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"margin-bottom: 10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span>&nbsp;&nbsp;&nbsp;<\/span><\/section>\n<section style=\"margin-top: -2px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: bottom;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;display: inline-block;border-width: 1px;border-style: solid;border-color: rgb(255, 255, 255);width: 30px;height: 30px;line-height: 30px;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-right: auto;margin-left: auto;max-width: 100%;min-height: 1em;white-space: pre-wrap;min-width: 1px;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">01<\/p>\n<\/section>\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 3px;margin-left: -33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><span style=\"margin-bottom: -10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span>&nbsp; &nbsp;<\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(123, 12, 0);font-size: 16px;letter-spacing: 0.544px;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;text-align: justify;\">\u7814\u7a76\u7ed3\u679c<\/span><\/span><\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(123, 12, 0);font-size: 16px;letter-spacing: 0.544px;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 15px;text-align: justify;\"><br  \/><\/span><\/span><\/span><\/strong><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5177\u4f53\u800c\u8a00\uff0c\u8be5\u5c0f\u7ec4\u7684\u76ee\u6807\u662f<strong>\u5c06PTEN\u7684\u529f\u80fd\u62f7\u8d1d\u91cd\u65b0\u5f15\u5165\u764c\u7ec6\u80de\uff0c\u4ee5\u9006\u8f6c\u4eba\u4f53\u7684\u5929\u7136\u80bf\u7624\u6291\u5236\u673a\u5236<\/strong>\u3002\u4e3a\u4e86\u505a\u5230\u8fd9\u4e00\u70b9\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86<strong>mRNA\u7eb3\u7c73\u7c92\u5b50<\/strong>\uff0c\u8fd9\u662f\u4e00\u79cd\u8d85\u5c0f\u578b\u8fd0\u8f7d\u5de5\u5177\uff0c\u53ef\u4ee5\u5c06\u9057\u4f20\u4fe1\u606f\u4f20\u9012\u5230\u7ec6\u80de\u4e2d\u3002\u8be5\u5c0f\u7ec4\u5728\u5b9e\u9a8c\u5ba4\u6d4b\u8bd5\u4e86\u6df7\u5408\u7eb3\u7c73\u9897\u7c92\u5bf9\u524d\u5217\u817a\u764c\u7ec6\u80de\u7684\u5f71\u54cd\uff0c\u53d1\u73b0\u7eb3\u7c73\u9897\u7c92\u53ef\u4ee5\u6709\u6548<strong>\u6e17\u900f\u7ec6\u80de\uff0c\u4fdd\u62a4mRNA\u514d\u53d7\u964d\u89e3\uff0c\u6062\u590d\u80bf\u7624\u6291\u5236\u529f\u80fd\uff0c\u6740\u6b7b\u764c\u7ec6\u80de\u3002<\/strong><\/span><br  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8be5\u5c0f\u7ec4\u8fd8\u62a5\u9053\uff0c\u5728\u5c0f\u9f20\u524d\u5217\u817a\u764c\u6a21\u578b\uff0c\u5305\u62ec\u524d\u5217\u817a\u764c\u9aa8\u6a21\u578b(\u524d\u5217\u817a\u764c\u6700\u5e38\u89c1\u7684\u4f20\u64ad\u90e8\u4f4d)\u4e2d\uff0c\u80bf\u7624\u751f\u957f\u548c\u8fdb\u5c55\u53d7\u5230\u663e\u8457\u6291\u5236\u3002\u5229\u7528\u6210\u50cf\u5206\u6790\uff0c\u7814\u7a76\u5c0f\u7ec4\u76f4\u89c2\u5730\u8bc1\u5b9e\u4e86\u8fd9\u4e9b\u7ed3\u679c\uff0c\u53d1\u73b0\u901a\u8fc7\u7eb3\u7c73\u7c92\u5b50\u4f20\u9012\u7684PTEN mRNA\u662f\u764c\u7ec6\u80de\u7834\u574f\u589e\u52a0\u7684\u539f\u56e0\u3002\u6b64\u5916\uff0c\u7814\u7a76\u5c0f\u7ec4\u62a5\u544a\u4e86\u8fd9\u79cd\u6cbb\u7597\u7b56\u7565\u7684\u5b89\u5168\u6027\u8bc1\u636e\u2014\u2014\u5c0f\u9f20\u4f53\u91cd\u6ca1\u6709\u663e\u8457\u53d8\u5316\uff0c\u4e5f\u6ca1\u6709\u5668\u5b98\u6bd2\u6027\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><img class=\"\"     style=\"margin-top: 6px;margin-bottom: 6px;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1537927735.jpeg\" alt=\"\u9996\u4e2a\uff01\u7eb3\u7c73\u6280\u672f\u4ecb\u5165\u6291\u764c\u57fa\u56e0\u5728\u524d\u5217\u817a\u764c\u4e2d\u53d6\u5f97\u7a81\u7834\u8fdb\u5c55 | Nature\u5b50\u520a\" title=\"\u9996\u4e2a\uff01\u7eb3\u7c73\u6280\u672f\u4ecb\u5165\u6291\u764c\u57fa\u56e0\u5728\u524d\u5217\u817a\u764c\u4e2d\u53d6\u5f97\u7a81\u7834\u8fdb\u5c55 | Nature\u5b50\u520a\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<section class=\"\"  style=\"max-width: 100%;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin: 10px auto;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 3px;margin-left: 33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"margin-bottom: 10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span>&nbsp;&nbsp;&nbsp;<\/span><\/section>\n<section style=\"margin-top: -2px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: bottom;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;display: inline-block;border-width: 1px;border-style: solid;border-color: rgb(255, 255, 255);width: 30px;height: 30px;line-height: 30px;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-right: auto;margin-left: auto;max-width: 100%;min-height: 1em;white-space: pre-wrap;min-width: 1px;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">02<\/p>\n<\/section>\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 3px;margin-left: -33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><span style=\"margin-bottom: -10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span>&nbsp; &nbsp;<\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(123, 12, 0);font-size: 16px;letter-spacing: 0.544px;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u91cd\u8981\u610f\u4e49<\/span><\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(123, 12, 0);font-size: 16px;letter-spacing: 0.544px;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/span><\/strong><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u5927\u591a\u6570\u764c\u75c7\u7597\u6cd5\u4f1a\u963b\u6b62\u67d0\u4e9b\u4e1c\u897f\uff08\u6bd4\u5982\u81f4\u764c\u57fa\u56e0\uff09\uff0c\u6765\u4f7f\u80bf\u7624\u7ec6\u80de\u5f02\u5e38\u3002\u6ce2\u58eb\u987f\u513f\u7ae5\u533b\u9662\u8840\u7ba1\u751f\u7269\u5b66\u9879\u76ee\u7684\u53e6\u4e00\u901a\u8baf\u4f5c\u8005Bruce R. Zetter\u535a\u58eb\u6307\u51fa\uff0c\u201c\u5728\u8fd9\u79cd\u65b9\u6cd5\u4e2d\uff0c\u6211\u4eec\u6dfb\u52a0\u4e86\u4e00\u79cd\u86cb\u767d\u8d28\uff0c\u4f7f\u80bf\u7624\u7ec6\u80de\u66f4\u50cf\u6b63\u5e38\u7ec6\u80de\uff0c\u4e0d\u592a\u53ef\u80fd\u751f\u957f\u5931\u63a7\u3002\u201d<\/span><br  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4f5c\u8005\u4e4b\u4e00\u3001\u7eaa\u5ff5\u65af\u9686\u2022\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u7684\u533b\u5b66\u7cfb\u4e3b\u4efbPhilip Kantoff\u535a\u58eb\u8bf4\uff0c\u201c\u4e34\u5e8a\u6807\u672c\u7684\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u663e\u793a\uff0c\u5305\u62ecPTEN\u5728\u5185\u7684\u4e0d\u540c\u80bf\u7624\u6291\u5236\u56e0\u5b50\u7684\u9010\u6e10\u4e22\u5931\/\u5931\u6d3b\u4e0e\u524d\u5217\u817a\u764c\u7684\u53d1\u5c55\u548c\u8f6c\u79fb\u76f8\u5173\uff0c\u4eba\u4eec\u975e\u5e38\u9700\u8981\u6062\u590d\u80bf\u7624\u6291\u5236\u9014\u5f84\uff0c\u7a81\u51fa\u8fd9\u9879\u5de5\u4f5c\u7684\u4e34\u5e8a\u610f\u4e49\u3002\u201d<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u5bf9\u4e8e\u6838\u9178\u6cbb\u7597\u9886\u57df\u6765\u8bf4\uff0c\u8fd9\u662f\u6fc0\u52a8\u4eba\u5fc3\u7684\u65f6\u523b\uff0c\u9996\u4e2asiRNA\u7597\u6cd5\u548c\u4f17\u591a\u4e34\u5e8a\u7814\u7a76\u4e2d\u7684mRNA\u7597\u6cd5\u6700\u8fd1\u5f97\u5230\u4e86\u76d1\u7ba1\u673a\u6784\u7684\u6279\u51c6\uff0c\u8fd9\u9879\u5de5\u4f5c\u662f<strong>\u4f7f\u7528\u7eb3\u7c73\u6280\u672f\u7cfb\u7edf\u9012\u9001mRNA\u4ee5\u6062\u590d\u4f53\u5185\u80bf\u7624\u751f\u957f\u6291\u5236\u7684\u7b2c\u4e00\u4e2a\u6982\u5ff5\u8bc1\u660e<\/strong>\uff0c\u5305\u62ec\u5728\u80bf\u7624\u8d1f\u62c5\u5e7f\u6cdb\u5206\u5e03\u7684\u8f6c\u79fb\u73af\u5883\u4e2d\u3002\u6211\u4eec\u7684\u65b9\u6cd5\u53ef\u80fd\u88ab\u8bc1\u660e\u5728\u6cbb\u7597<strong>\u5404\u79cd\u6076\u6027\u80bf\u7624<\/strong>\u65b9\u9762\u662f\u6709\u7528\u7684\uff0c\u201d\u4f5c\u8005\u4e4b\u4e00\u3001\u7eb3\u7c73\u533b\u5b66\u4e2d\u5fc3\u4e3b\u4efb\u3001BWH\u9ebb\u9189\u6559\u6388Omid Farokhzad\u8bf4\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4f5c\u8005\u5f3a\u8c03\uff0c\u8fd9\u9879\u5de5\u4f5c\u662f\u4e00\u9879\u6982\u5ff5\u9a8c\u8bc1\u7814\u7a76\uff0c\u8bc1\u660e\u4e86\u8fd9\u79cd\u65b9\u6cd5\u7684\u6f5c\u5728\u5f71\u54cd\uff0c\u4f46\u5728\u7528\u4e8e\u4eba\u7c7b\u4e4b\u524d\uff0c\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u6d4b\u8bd5\u548c\u9a8c\u8bc1\u3002\u8be5\u5c0f\u7ec4\u5c06\u7ee7\u7eed\u6d4b\u8bd5\u8fd9\u79cd\u65b9\u6cd5\uff0c\u5e76\u8ba1\u5212\u63a2\u7d22\u5176\u5728\u5176\u4ed6\u80bf\u7624\u6291\u5236\u56e0\u5b50(\u5982P53 )\u4e2d\u7684\u5e94\u7528\uff0c\u4ee5\u53ca\u5c06\u8fd9\u79cd\u7b56\u7565\u4e0e\u5176\u4ed6\u7597\u6cd5\u76f8\u7ed3\u5408\u7684\u80fd\u529b\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: right;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">\u8d23\u7f16\uff1a\u6d6e\u82cf<\/span><\/strong><\/p>\n<section  class=\"\" style=\"max-width: 100%;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  class=\"\" style=\"max-width: 100%;line-height: 28.4444px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section  style=\"margin: 1em auto;max-width: 100%;border-width: 0px;border-style: none;border-color: initial;text-align: center;width: 941px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span class=\"\"  style=\"max-width: 100%;width: 941px;border-bottom: 1px solid rgb(172, 29, 16);border-top-color: rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-left-color: rgb(172, 29, 16);display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/p>\n<section class=\"\" style=\"margin-bottom: -3px;padding-top: 5px;padding-right: 10px;padding-left: 10px;max-width: 100%;display: inline-block;min-height: 32px;border-bottom: 5px solid rgb(172, 29, 16);font-size: 20px;color: rgb(121, 121, 121);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-top: 5px;margin-bottom: 5px;max-width: 100%;min-height: 1em;line-height: 1.6em;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">End<\/p>\n<\/section>\n<p><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/strong><span style=\"font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 12px;\">1\uff09Nanoparticle therapeutic restores function of tumor suppressor in prostate cancer<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 1.75em;\"><span style=\"max-width: 100%;font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\">2\uff09Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 1.75em;\"><span style=\"max-width: 100%;font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<section  class=\"\" style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;text-align: justify;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);line-height: 25.6px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"padding: 2px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: dotted;border-color: rgb(218, 98, 71);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin: 5px auto;max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;width: 50px;float: left;border-top: 2px solid rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-bottom-color: rgb(172, 29, 16);border-left: 2px solid rgb(172, 29, 16);color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;display: inline-block;color: rgb(172, 29, 16);clear: both;border-color: rgb(172, 29, 16);word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section class=\"\"  style=\"margin: -0.8em 0.3em;padding: 0.8em;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;color: inherit;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;overflow-wrap: break-word;color: rgb(51, 51, 51);font-size: 1em;line-height: 1.75em;word-break: break-all;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"max-width: 100%;color: rgb(0, 0, 0);line-height: 22.4px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u672c\u6587\u7cfb\u751f\u7269\u63a2\u7d22\u539f\u521b\uff0c\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u5206\u4eab\u3002\u5176\u4ed6\u4efb\u4f55\u5a92\u4f53\u3001\u7f51\u7ad9\u5982\u9700\u8f6c\u8f7d\uff0c\u987b\u5728\u6b63\u6587\u524d\u6ce8\u660e\u6765\u6e90\u751f\u7269\u63a2\u7d22\u3002<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;width: 50px;float: right;border-bottom: 2px solid rgb(172, 29, 16);border-top-color: rgb(172, 29, 16);border-right: 2px solid rgb(172, 29, 16);border-left-color: rgb(172, 29, 16);color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4f17\u6240\u5468\u77e5\uff0c\u6291\u764c\u57fa\u56e0PTEN\u548cP53\u7b49\u7684\u7a81\u53d8\u548c\u7f3a\u5931\u4f1a\u5bfc\u81f4\u764c\u75c7\u4e0d\u53d7\u6291\u5236\u5730\u751f\u957f\u3002\u9488\u5bf9\u76f8\u5173\u57fa\u56e0\u7a81\u53d8\u7684\u7814\u7a76\u6709\u5f88\u591a\uff0c\u800c\u9488\u5bf9 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":50420,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/50419"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=50419"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/50419\/revisions"}],"predecessor-version":[{"id":50423,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/50419\/revisions\/50423"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/50420"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=50419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=50419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=50419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}