{"id":50428,"date":"2018-09-19T01:00:00","date_gmt":"2018-09-26T02:09:05","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e5%8f%88%e4%b8%80%e8%bf%9b%e6%ad%a5%ef%bc%81%e5%9f%ba%e5%9b%a0%e7%96%97%e6%b3%95%e6%b8%85%e9%99%a4%e5%b8%95%e9%87%91%e6%a3%ae%e8%87%b4%e7%97%85%e8%9b%8b%e7%99%bd%e6%8c%87%e6%97%a5%e5%8f%af%e5%be%85\/"},"modified":"2018-09-26T10:09:06","modified_gmt":"2018-09-26T02:09:06","slug":"%e5%8f%88%e4%b8%80%e8%bf%9b%e6%ad%a5%ef%bc%81%e5%9f%ba%e5%9b%a0%e7%96%97%e6%b3%95%e6%b8%85%e9%99%a4%e5%b8%95%e9%87%91%e6%a3%ae%e8%87%b4%e7%97%85%e8%9b%8b%e7%99%bd%e6%8c%87%e6%97%a5%e5%8f%af%e5%be%85","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/50428\/","title":{"rendered":"\u53c8\u4e00\u8fdb\u6b65\uff01\u57fa\u56e0\u7597\u6cd5\u6e05\u9664\u5e15\u91d1\u68ee\u81f4\u75c5\u86cb\u767d\u6307\u65e5\u53ef\u5f85 \u200b"},"content":{"rendered":"
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\u751f\u7269\u63a2\u7d22<\/span><\/section>\n

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\u7f16\u8005\u6309<\/strong><\/span><\/section>\n<\/section>\n
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\u5e15\u91d1\u68ee\u75c5\u662f\u4e00\u79cd\u6162\u6027\u8fdb\u884c\u6027\u8fd0\u52a8\u969c\u788d\uff0c\u5f71\u54cd\u8eab\u4f53\u63a7\u5236\u8fd0\u52a8\u7684\u80fd\u529b\uff0c\u76ee\u524d\u5c1a\u65e0\u6709\u6548\u6cbb\u7597\u65b9\u6cd5\u3002\u8fd1\u65e5\uff0c\u7531\u62c9\u4ec0\u533b\u5b66\u9662(Rush Medical College)\u7684\u7814\u7a76\u4eba\u5458 Jeffrey Kordower\u535a\u58eb\u9886\u5bfc\u7684\u4e00\u4e2a\u56fd\u9645\u5c0f\u7ec4\u5728\u5e15\u91d1\u68ee\u6cbb\u7597\u4e2d\u8fc8\u51fa\u91cd\u8981\u4e00\u6b65\uff1a\u5229\u7528\u57fa\u56e0\u7597\u6cd5\u6e05\u9664\u81f4\u75c5\u86cb\u767d\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/fieldset>\n<\/section>\n


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\"\u53c8\u4e00\u8fdb\u6b65\uff01\u57fa\u56e0\u7597\u6cd5\u6e05\u9664\u5e15\u91d1\u68ee\u81f4\u75c5\u86cb\u767d\u6307\u65e5\u53ef\u5f85<\/p>\n

DOI\uff1ahttps:\/\/doi.org\/10.1038\/s41531-018-0062-4<\/span><\/p>\n


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8\u670822\u65e5\uff0c\u300anpj Parkinson’s Disease\u300b\u6742\u5fd7\u4ee5\u201cProteasome-targeted nanobodies alleviate pathology and functional decline in an \u03b1-synuclein-based Parkinson\u2019s disease model\u201d\u4e3a\u9898\u53d1\u8868\u4e86\u8fd9\u4e00\u7814\u7a76\u7ed3\u679c\u3002<\/span><\/p>\n


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\u5e15\u91d1\u68ee\u75c5\u6e90\u4e8e\u5bf9\u4ea7\u751f\u591a\u5df4\u80fa\u7684\u8111\u7ec6\u80de\u7684\u635f\u5bb3\u3002\u591a\u5df4\u80fa\u662f\u4e00\u79cd\u5316\u5b66\u7269\u8d28\uff0c\u5b83\u5c06\u4fe1\u606f\u4f20\u9012\u7ed9\u5927\u8111\u4e2d\u63a7\u5236\u8fd0\u52a8\u7684\u90e8\u5206\uff0c\u591a\u5df4\u80fa\u7684\u5f02\u5e38\u4f1a\u5bfc\u81f4\u98a4\u6296\u3001\u50f5\u786c\u3001\u7f13\u6162\u8fd0\u52a8\u4ee5\u53ca\u5e73\u8861\u548c\u534f\u8c03\u4e0d\u826f\u3002<\/span><\/p>\n


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Kordower\u56e2\u961f\u5728\u6a21\u62df\u5e15\u91d1\u68ee\u75c5\u7684\u5927\u9f20\u8eab\u4e0a\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u5c06\u4e00\u79cd\u53eb\u505a\u7eb3\u7c73\u4f53\uff08nanobody\uff09<\/strong>\u7684\u6297\u4f53\u57fa\u56e0\u5de5\u7a0b\u7247\u6bb5\u6ce8\u5165\u5927\u9f20\u5927\u8111\u540e\uff0c\u53ef\u6709\u6548\u6e05\u9664\u86cb\u767d\u8d28\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u7684\u6709\u6bd2\u56e2\u5757\u3002<\/span><\/p>\n


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\"\u53c8\u4e00\u8fdb\u6b65\uff01\u57fa\u56e0\u7597\u6cd5\u6e05\u9664\u5e15\u91d1\u68ee\u81f4\u75c5\u86cb\u767d\u6307\u65e5\u53ef\u5f85<\/p>\n

\u5e15\u91d1\u68ee\u60a3\u8005\u9ed1\u8d28\u533a\u57df\u7684\u663e\u5fae\u7167\u7247\u663e\u793a\u4e86\u8def\u6613\u4f53\u548c\u8def\u6613\u795e\u7ecf\u7a81\u8d77\u7684\u4e0d\u540c\u653e\u5927\u500d\u6570\u3002\u4e0a\u56fe\u663e\u793a\u805a\u96c6\u5f62\u6210\u8def\u6613\u4f53\u7684\u03b1\u7a81\u89e6\u6838\u86cb\u767d\u795e\u7ecf\u5185\u5185\u542b\u7269\u653e\u5927\u4e8660\u500d\u3002\u5e95\u90e8\u9762\u677f\u662f20\u500d\u653e\u5927\u7684\u56fe\u50cf\uff0c\u663e\u793a\u4e86\u5404\u79cd\u5c3a\u5bf8\u7684\u7ebf\u72b6Lewy\u795e\u7ecf\u7a81\u8d77\u548c\u5706\u5f62Lewy\u8eab\u4f53\u3002\u80cc\u666f\u4e2d\u53ef\u89c1\u9ed1\u8d28\u5bcc\u542b\u795e\u7ecf\u9ed1\u8272\u7d20\u7684\u7ec6\u80de\u3002\u4f7f\u7528\u7684\u67d3\u8272\u5242:\u5927\u9f20\u5355\u514b\u9686\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u6297\u4f53\uff1b\u7528\u8fc8\u5c14\u82cf\u6728\u7cbe\u590d\u67d3\u3002\u6765\u6e90: Suraj Rajan<\/span><\/p>\n


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01<\/p>\n<\/section>\n

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\u4ece\u5185\u90e8\u56fa\u5b9a\u7ec6\u80de<\/span><\/span><\/span><\/strong><\/p>\n


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\u03b1-\u7a81\u89e6\u6838\u86cb\u767d<\/span><\/strong>\uff0c\u7b80\u79f0\u03b1-\u7a81\u89e6\uff0c\u81ea\u7136\u5b58\u5728\u4e8e\u5927\u8111\u548c\u8eab\u4f53\u7684\u5176\u4ed6\u5730\u65b9\u3002\u7136\u800c\uff0c\u5728\u795e\u7ecf\u75be\u75c5\u4e2d\uff0c\u86cb\u767d\u8d28\u7c07\u4ee5\u9519\u8bef\u6298\u53e0(\u5f02\u5e38\u805a\u96c6\u5728\u4e00\u8d77)\u548c\u7d0a\u4e71\u7684\u5f62\u5f0f\u51fa\u73b0\u3002\u5728\u5e15\u91d1\u68ee\u6c0f\u75c5\u4e2d\uff0c\u7578\u5f62\u7684\u03b1-\u7a81\u89e6\u805a\u96c6\u5728\u88ab\u79f0\u4e3a\u8def\u6613\u4f53\uff08Lewy bodies\uff09\u7684\u72ec\u7279\u7ed3\u6784\u4e2d\uff0c\u8fd9\u88ab\u8ba4\u4e3a\u662f\u5e15\u91d1\u68ee\u75c5\u7684\u4e00\u4e2a\u7ec4\u6210\u90e8\u5206\u3002<\/span>
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Kordower\u8bf4:\u201c\u6211\u4eec\u6b63\u5728\u5bfb\u627e\u964d\u4f4e\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u6c34\u5e73\u7684\u65b9\u6cd5\uff0c\u4ee5\u51cf\u5c11\u7531\u4e8e\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u5728\u795e\u7ecf\u7cfb\u7edf\u5468\u56f4\u6269\u6563\u800c\u5bfc\u81f4\u7684\u79ef\u7d2f\u548c\u6bd2\u6027\u3002\u201d<\/span><\/p>\n


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\u4ed6\u7684\u56e2\u961f\u6b63\u5728\u6d4b\u8bd5\u7684\u8fd9\u79cd\u65b9\u6cd5\u662f\u5c06\u6cbb\u7597\u6027\u7eb3\u7c73\u4f53\u4f5c\u4e3a\u57fa\u56e0\u6539\u53d8\u75c5\u6bd2\u7684\u4e00\u90e8\u5206\u6765\u5165\u4fb5\u7ec6\u80de\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u4e00\u65e6\u8fdb\u5165\u7ec6\u80de\uff0c\u7eb3\u7c73\u4f53\u4f3c\u4e4e\u5c31\u7ec8\u6b62\u4e86\u56e0\u529f\u80fd\u5931\u8c03\u7684\u03b1-\u7a81\u89e6\u805a\u96c6\u5bfc\u81f4\u7684\u795e\u7ecf\u7ec6\u80de\u7684\u4e27\u5931\uff0c\u8fdb\u800c\u9632\u6b62\u4e86\u75be\u75c5\u7684\u53d1\u5c55\u3002<\/span><\/p>\n


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\u8fd9\u9879\u7814\u7a76\u9996\u6b21\u5c06\u7eb3\u7c73\u4f53\u7528\u4e8e\u5e15\u91d1\u68ee\u75c5<\/strong>\u3002\u4e00\u4e9b\u5148\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u6e05\u9664\u7ec6\u80de\u5916\u533a\u57df\u7684\u03b1-\u7a81\u89e6\u662f\u6709\u5e0c\u671b\u7684\uff0c\u4f46\u662fKordower\u8ba4\u4e3a\u7ec6\u80de\u5185\u7684\u65b9\u6cd5\u53ef\u80fd\u66f4\u6709\u6548\uff0c\u56e0\u4e3a\u7ec6\u80de\u5185\u7684\u03b1- \u7a81\u89e6<\/span>\u6570\u91cf\u6bd4\u7ec6\u80de\u5916\u7684\u591a\u3002 \u201c\u5982\u679c\u4f60\u964d\u4f4e\u7ec6\u80de\u5185\u6c34\u5e73\uff0c\u90a3\u4e48a-\u7a81\u89e6\u6838\u86cb\u767d\u5f88\u53ef\u80fd\u4e0d\u4f1a\u8fdb\u5165\u7ec6\u80de\u5916\uff0c\u56e0\u6b64\u4e5f\u5c31\u4e0d\u4f1a\u6269\u6563\u3002\u201d Kordower\u89e3\u91ca\u9053\u3002<\/span><\/p>\n


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\u4f7fPEST\u8fdb\u5165\u7ec6\u80de\u5185<\/span><\/span><\/span><\/strong><\/p>\n


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\u5177\u4f53\u6765\u8bf4\uff0c\u4ed6\u7684\u56e2\u961f\u5728\u53d7\u8bd5\u5927\u9f20\u7684\u5927\u8111\u4e2d\u521b\u9020\u4e86\u03b1- \u7a81\u89e6<\/span>\u7684\u8fc7\u91cf\u8868\u8fbe\u3002\u7136\u540e\uff0c\u4ed6\u4eec\u5728\u4e0d\u540c\u5927\u9f20\u8eab\u4e0a\u6d4b\u8bd5\u4e86\u4e24\u79cd\u7c7b\u578b\u7684\u57fa\u56e0\u7597\u6cd5\uff0c\u5e76\u5728\u5bf9\u7167\u7ec4\u4e2d\u4f7f\u7528\u751f\u7406\u76d0\u6c34\uff0c\u770b\u770b\u7eb3\u7c73\u4f53\u662f\u5426\u80fd\u6e05\u9664\u8fd9\u4e9b\u7ec6\u80de\u5185\u7684\u6742\u7269\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8fd9\u4e9b\u7eb3\u7c73\u4f53\u662f\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u77e2\u91cf\u6838\u5fc3\u4e3a\u8fd9\u9879\u7814\u7a76\u5b9a\u5236\u7684\u3002<\/span>
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\u7814\u7a76\u4eba\u5458\u8fdb\u4e00\u6b65\u89e3\u91ca\uff0cVH14 * PEST\u901a\u8fc7\u964d\u4f4e\u03b1-\u7a81\u89e6\u4e2d\u88ab\u79f0\u4e3a\u4e1d\u6c28\u9178-129\u7684\u6c28\u57fa\u9178\u6c34\u5e73\u6765\u5b9e\u73b0\u8fd9\u4e9b\u7ed3\u679c\uff0c\u8be5\u6c28\u57fa\u9178\u7ecf\u5386\u4e86\u78f7\u9178\u5316\u53cd\u5e94\u3002\u4e1d\u6c28\u9178-129\u662f\u03b1-\u7a81\u89e6\u7684\u6b63\u5e38\u6210\u5206\uff0c\u4f46\u662f\u78f7\u9178\u5316\u7684\u4e1d\u6c28\u9178-129\u4f1a\u5bfc\u81f4\u03b1-\u7a81\u89e6\u7684\u7578\u5f62\u3002<\/span><\/p>\n


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03<\/p>\n<\/section>\n

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\u4f7fPEST\u4eba\u6027\u5316<\/span><\/span><\/span><\/strong><\/p>\n


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\u9274\u4e8eVH14 *PEST\u6cbb\u7597\u663e\u793a\u51fa\u6709\u5e0c\u671b\u7684\u7ed3\u679c\uff0cKordower\u548c\u4ed6\u7684\u56e2\u961f\u8ba1\u5212\u5f00\u5c55\u8fdb\u4e00\u6b65\u7814\u7a76\u3002\u7136\u800c\uff0c\u8be5\u5c0f\u7ec4\u9996\u5148\u5fc5\u987b\u5c06\u5b83\u5728\u5927\u9f20\u6a21\u578b\u4e2d\u4f7f\u7528\u7684\u5316\u5408\u7269\u5b8c\u5168\u201c\u4eba\u6027\u5316\u201d\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u4ed6\u4eec\u5fc5\u987b\u786e\u4fdd\u4eba\u4eec\u7684\u5b89\u5168\u3002<\/span><\/p>\n


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Kodower\u89e3\u91ca\u9053:\u201c\u968f\u540e\u6211\u4eec\u5fc5\u987b\u5728\u5927\u9f20\u8eab\u4e0a\u91cd\u590d\u8fd9\u4e9b\u7814\u7a76\uff0c\u7528\u4eba\u6027\u5316\u7684\u7248\u672c\u6765\u786e\u4fdd\u5b83\u548c\u6211\u4eec\u4e00\u76f4\u5728\u6d4b\u8bd5\u7684\u4e00\u6837\u6709\u6548\u3002\u9002\u65f6\u6211\u4eec\u624d\u80fd\u8003\u8651\u5728\u4eba\u7c7b\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4f7f\u7528\u8fd9\u79cd\u7597\u6cd5\u3002\u201d<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/strong>1\uff09Gene therapy shown to remove core component of Parkinson’s disease<\/span><\/p>\n

2\uff09Proteasome-targeted nanobodies alleviate pathology and functional decline in an \u03b1-synuclein-based Parkinson\u2019s disease model<\/span><\/p>\n


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