{"id":50445,"date":"2018-09-18T01:00:00","date_gmt":"2018-09-26T02:09:16","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e4%b8%89%e7%af%87nejm%e9%bd%90%e5%8f%91%ef%bc%81%e6%af%8f%e6%97%a5%e4%bd%8e%e5%89%82%e9%87%8f%e6%9c%8d%e7%94%a8%e9%98%bf%e5%8f%b8%e5%8c%b9%e6%9e%97%ef%bc%8c%e5%b9%b6%e4%b8%8d%e4%bc%9a%e5%bb%b6\/"},"modified":"2018-09-26T10:09:17","modified_gmt":"2018-09-26T02:09:17","slug":"%e4%b8%89%e7%af%87nejm%e9%bd%90%e5%8f%91%ef%bc%81%e6%af%8f%e6%97%a5%e4%bd%8e%e5%89%82%e9%87%8f%e6%9c%8d%e7%94%a8%e9%98%bf%e5%8f%b8%e5%8c%b9%e6%9e%97%ef%bc%8c%e5%b9%b6%e4%b8%8d%e4%bc%9a%e5%bb%b6","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/50445\/","title":{"rendered":"\u4e09\u7bc7NEJM\u9f50\u53d1\uff01\u6bcf\u65e5\u4f4e\u5242\u91cf\u670d\u7528\u963f\u53f8\u5339\u6797\uff0c\u5e76\u4e0d\u4f1a\u5ef6\u957f\u5bff\u547d"},"content":{"rendered":"
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\u4e4b\u524d\u300a\u67f3\u53f6\u5200\u300b\u53d1\u6587\u79f0\uff0c\u201c\u795e\u836f\u201d\u963f\u53f8\u5339\u6797\u5728\u9884\u9632\u5fc3\u810f\u75c5\u548c\u4e2d\u98ce\u4e0a\u5e76\u6ca1\u6709\u201c\u5b9a\u8bba\u201d\u3002\u73b0\u5728\uff0c\u300aNew England Journal of Medicine\u300b\u671f\u520a\u540c\u6837\u201c\u8c28\u614e\u201d\u8868\u6001\uff1a\u5bf9\u4e8e\u5065\u5eb7\u7684\u8001\u5e74\u4eba\uff08\u65e0\u5fc3\u8840\u7ba1\u75be\u75c5\uff09\uff0c\u6bcf\u5929\u670d\u7528\u4f4e\u5242\u91cf\u963f\u53f8\u5339\u6797\u5e76\u4e0d\u4f1a\u5ef6\u957f\u5bff\u547d\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/fieldset>\n<\/section>\n

\"\u4e09\u7bc7NEJM\u9f50\u53d1\uff01\u6bcf\u65e5\u4f4e\u5242\u91cf\u670d\u7528\u963f\u53f8\u5339\u6797\uff0c\u5e76\u4e0d\u4f1a\u5ef6\u957f\u5bff\u547d\"
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\u963f\u53f8\u5339\u6797\u88ab\u8a89\u4e3a\u201c\u795e\u836f\u201d\uff0c\u6e90\u4e8e\u5b83\u9664\u4e86\u6700\u521d\u7684\u9547\u75db\u6d88\u708e\u4e4b\u5916\uff0c\u8fd8\u88ab\u8bc1\u5b9e\u5728\u6297\u8840\u6813\u3001\u6297\u764c\u7b49\u591a\u65b9\u9762\u53d1\u6325\u7740\u79ef\u6781\u7684\u6f5c\u80fd\u3002\u201c\u4e34\u5e8a\u6307\u5357\u8868\u660e\uff0c\u51a0\u5fc3\u75c5\u7b49\u5fc3\u8840\u7ba1\u75be\u75c5\u60a3\u8005\u670d\u7528\u963f\u53f8\u5339\u6797\u53ef\u4ee5\u9884\u9632\u5fc3\u810f\u75c5\u3001\u4e2d\u98ce\u3002\u201d NIA\u4e3b\u4efbRichard J. Hodes\u8868\u793a\uff0c\u201c\u4f46\u662f\u4eba\u4eec\u66f4\u5173\u5fc3\u7684\u662f\uff0c\u963f\u53f8\u5339\u6797\u5bf9\u4e8e\u6ca1\u6709\u8fd9\u4e9b\u75be\u75c5\u7684\u5065\u5eb7\u8001\u5e74\u4eba\uff0c\u662f\u5426\u6709\u76f8\u540c\u7684\u76ca\u5904\uff1f<\/strong>\u201d<\/span><\/p>\n


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9\u670816\u65e5\uff0c\u300aNew England Journal of Medicine\u300b\u671f\u520a\u540c\u65f6\u53d1\u8868\u4e09\u7bc7\u6587\u7ae0\u7ed9\u51fa\u4e86\u6700\u65b0\u7b54\u6848\uff1a\u5bf9\u4e8e\u5065\u5eb7\u7684\u8001\u5e74\u4eba\uff08\u65e0\u5fc3\u8840\u7ba1\u75be\u75c5\uff09\uff0c\u6bcf\u5929\u670d\u7528\u4f4e\u5242\u91cf\u963f\u53f8\u5339\u6797\u5e76\u4e0d\u4f1a\u5ef6\u957f\u5bff\u547d\u3002<\/strong>\u800c\u4e14\uff0c\u8001\u5e74\u4eba\u82e5\u5c06\u670d\u7528\u4f4e\u5242\u91cf\u963f\u53f8\u5339\u6797\u4f5c\u4e3a\u4e3b\u8981\u7684\u9884\u9632\u5fc3\u8840\u7ba1\u75be\u75c5\u7b56\u7565\uff0c\u5bb9\u6613\u589e\u52a0\u5927\u51fa\u8840\u7684\u98ce\u9669\u3002\u540c\u65f6\uff0c\u8fd9\u4e00\u7b56\u7565\u5e76\u6ca1\u6709\u5bfc\u81f4\u5fc3\u8840\u7ba1\u75be\u75c5\u98ce\u9669\u660e\u663e\u4f4e\u4e8e\u5b89\u6170\u5242\u7ec4\u3002<\/strong><\/span><\/p>\n


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\u83ab\u7eb3\u4ec0\u5927\u5b66\u6d41\u884c\u75c5\u5b66\u548c\u9884\u9632\u5065\u5eb7\u7cfb\u4e3b\u4efbJohn J. McNeil\u5e26\u9886\u56e2\u961f\u5b8c\u6210\u4e86\u76f8\u5173\u7814\u7a76\uff0c\u5176\u4e2d\u963f\u53f8\u5339\u6797\u548c\u5b89\u6170\u5242\u7531\u62dc\u8033\u516c\u53f8\uff08\u672a\u53c2\u4e0e\u8fd9\u9879\u7814\u7a76\uff09\u63d0\u4f9b\u3002<\/span><\/p>\n


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\u8fd9\u4e00\u7814\u7a76\uff08ASPREE\uff09\u662f\u4e00\u4e2a\u56fd\u9645\u6027\u3001\u968f\u673a\u3001\u53cc\u76f2\u7684\u5bf9\u7167\u6027\u8bd5\u9a8c\uff0c\u5171\u62db\u52df\u4e8619114\u540d\u8001\u5e74\u4eba\uff0816703\u540d\u6fb3\u5927\u5229\u4e9a\u4eba\uff0c2411\u540d\u7f8e\u56fd\u4eba\uff09\uff0c\u5f00\u59cb\u4e8e2010\u5e74\uff0c\u53c2\u4e0e\u8005\u5728\u767b\u8bb0\u65f6\u5747\u6ca1\u6709\u8001\u5e74\u75f4\u5446\u6216\u8005\u5176\u4ed6\u75be\u75c5\u3001\u6b8b\u75be\uff0c\u5e76\u4e14\u4e0d\u9700\u8981\u670d\u7528\u963f\u53f8\u5339\u6797\u3002\u4ed6\u4eec\u5e73\u5747\u88ab\u968f\u8bbf\u4e864.7\u5e74\u3002<\/span><\/p>\n


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\u53c2\u4e0e\u8005\u4eec\u6bcf\u5929\u670d\u7528100\u6beb\u514b\u7684\u4f4e\u5242\u91cf\u963f\u53f8\u5339\u6797\u6216\u8005\u5b89\u6170\u5242\u3002\u7ed3\u679c\u663e\u793a\uff0c\u963f\u53f8\u5339\u6797\u7ec490.3%\u7684\u53c2\u4e0e\u8005\u7ed3\u675f\u4e4b\u540e\u4ecd\u7136\u5065\u5eb7\u7684\u6d3b\u7740\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u8fd9\u4e00\u6bd4\u4f8b\u4e3a90.5%\u3002<\/span><\/p>\n


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\"\u4e09\u7bc7NEJM\u9f50\u53d1\uff01\u6bcf\u65e5\u4f4e\u5242\u91cf\u670d\u7528\u963f\u53f8\u5339\u6797\uff0c\u5e76\u4e0d\u4f1a\u5ef6\u957f\u5bff\u547d\"
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\u963f\u53f8\u5339\u6797\u7ec4\u6709\u66f4\u9ad8\u7684\u5168\u56e0\u6b7b\u4ea1\u7387<\/span><\/strong><\/p>\n


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\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u963f\u53f8\u5339\u6797\u7ec4\u4e2d\u67095.9%\u7684\u4eba\u5728\u7814\u7a76\u671f\u95f4\u6b7b\u4ea1\u3002\u5bf9\u7167\u7ec4\u8fd9\u4e00\u6bd4\u4f8b\u4e3a5.2%\u3002<\/strong>\u5176\u4e2d\uff0c 50%\u53bb\u4e16\u7684\u4eba\u90fd\u60a3\u6709\u67d0\u79cd\u764c\u75c7\uff0c\u6b64\u5916\u5fc3\u810f\u75c5\u3001\u4e2d\u98ce\u5360\u6b7b\u4ea1\u4eba\u6570\u768419%\uff0c\u5927\u51fa\u8840\u53605%\u3002<\/span><\/p>\n


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\u7814\u7a76\u4eba\u5458\u5206\u6790\uff0c\u6bcf\u5929\u670d\u7528\u963f\u53f8\u5339\u6797\u7684\u4eba\u6bd4\u670d\u7528\u5b89\u6170\u5242\u7684\u4eba\u6709\u66f4\u9ad8\u7684\u5168\u56e0\u6b7b\u4ea1\u7387\uff0c\u4e3b\u8981\u6e90\u4e8e\u8f83\u9ad8\u7684\u764c\u75c7\u6b7b\u4ea1\u7387\u3002<\/strong>\u6570\u636e\u663e\u793a\uff0c\u963f\u53f8\u5339\u6797\u7ec4\u51fa\u73b0\u65b0\u589e\u764c\u75c7\u60a3\u8005\u7684\u6bd4\u4f8b\u53d1\u751f\u5c0f\u5e45\u5ea6\u589e\u52a0\u3002\u4f46\u662f\uff0c\u7814\u7a76\u4eba\u5458\u5f3a\u8c03\uff0c\u8fd9\u4e00\u5dee\u5f02\u53ef\u80fd\u662f\u5076\u7136\u7684\u3002\u8fd9\u80cc\u540e\u7684\u539f\u56e0\u9700\u8981\u8c28\u614e\u8c03\u67e5\u3002<\/span><\/p>\n


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02<\/p>\n<\/section>\n

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\u963f\u53f8\u5339\u6797\u5e76\u672a\u964d\u4f4e\u5fc3\u8840\u7ba1\u75be\u75c5\u98ce\u9669<\/span><\/span><\/strong><\/p>\n


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\u540c\u65f6\uff0c\u7a76\u4eba\u5458\u8fd8\u5206\u6790\u4e86\u4e24\u7ec4\u53c2\u4e0e\u8005\u53d1\u751f\u5fc3\u8840\u7ba1\u75be\u75c5\uff08\u5305\u62ec\u51a0\u5fc3\u75c5\u3001\u975e\u81f4\u547d\u6027\u5fc3\u810f\u75c5\u53d1\u4f5c\u3001\u81f4\u547d\u548c\u975e\u81f4\u547d\u7684\u7f3a\u8840\u6027\u4e2d\u98ce\uff09\u7684\u53d1\u751f\u7387\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e24\u7ec4\u7684\u53d1\u751f\u6982\u7387\u76f8\u4f3c<\/strong>\u2014\u2014\u5728\u963f\u53f8\u5339\u6797\u7ec4\u6709448\u4eba\u53d1\u751f\u8fd9\u7c7b\u75be\u75c5\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u6709474\u4eba\u751f\u75c5\u3002<\/span><\/p>\n


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\u963f\u53f8\u5339\u6797\u589e\u52a0\u51fa\u8840\u98ce\u9669<\/span><\/span><\/strong><\/p>\n


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\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u963f\u53f8\u5339\u6797\u4e0e\u51fa\u8840\u98ce\u9669\u663e\u8457\u589e\u52a0\u6709\u5173\uff0c\u4e3b\u8981\u53d1\u751f\u5728\u80c3\u80a0\u9053\u548c\u5927\u8111<\/strong>\u2014\u2014361\u540d\u670d\u7528\u963f\u53f8\u5339\u6797\u7684\u53c2\u4e0e\u8005\uff083.8%\uff09\u53d1\u751f\u51fa\u8840\u4e8b\u4ef6\uff0c265\u540d\u670d\u7528\u5b89\u6170\u5242\u7684\u53c2\u4e0e\u8005\uff082.7%\uff09\u53d1\u751f\u51fa\u8840\u4e8b\u4ef6\u3002<\/span><\/p>\n


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\u201c\u963f\u53f8\u5339\u6797\u7ec4\u7684\u53c2\u4e0e\u8005\u56e0\u764c\u75c7\u800c\u53bb\u4e16\u7684\u6982\u7387\u589e\u52a0\uff0c\u8fd9\u662f\u5f88\u8ba9\u4eba\u610f\u5916\u7684\uff0c\u56e0\u4e3a\u5148\u524d\u7684\u7814\u7a76\u8868\u660e\u4f7f\u7528\u963f\u53f8\u5339\u6797\u53ef\u4ee5\u6539\u5584\u764c\u75c7\u9884\u540e\u3002\u201d\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u764c\u75c7\u9884\u9632\u79d1\u4e34\u5e8a\u7814\u7a76\u526f\u4e3b\u4efbLeslie Ford\u89e3\u91ca\u9053\u3002<\/span><\/p>\n


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\u7814\u7a76\u4eba\u5458\u5f3a\u8c03\uff0c\u8001\u5e74\u4eba\u5e94\u8be5\u8c28\u9075\u533b\u5631\uff0c\u5173\u4e8e\u6bcf\u5929\u662f\u5426\u670d\u7528\u963f\u53f8\u5339\u6797\u5e94\u8be5\u8be2\u95ee\u81ea\u5df1\u7684\u4e3b\u6cbb\u533b\u751f\u3002<\/strong>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u9879\u65b0\u53d1\u73b0\u5e76\u4e0d\u9002\u7528\u4e8e\u5df2\u7ecf\u670d\u7528\u8fc7\u963f\u53f8\u5339\u6797\u7684\u4eba\uff0c\u6bd4\u5982\u4e2d\u98ce\u3001\u5fc3\u810f\u75c5\u6216\u5176\u4ed6\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8fd9\u9879\u7814\u7a76\u5e76\u6ca1\u6709\u6d89\u53ca\u963f\u53f8\u5339\u6797\u5bf965\u5c81\u4ee5\u4e0b\u4eba\u7fa4\u7684\u5f71\u54cd\u3002<\/span><\/p>\n


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\u8d23\u7f16\uff1a\u98ce\u94c3<\/span><\/strong><\/p>\n

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End<\/p>\n<\/section>\n

<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/strong>1\uff09<\/span>Daily low-dose aspirin found to have no effect on healthy life span in older people<\/span><\/p>\n

2\uff09Effect of Aspirin on Disability-free Survival in the Healthy Elderly
<\/span><\/p>\n

3\uff09Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly
<\/span><\/p>\n

4\uff09Effect of Aspirin on All-Cause Mortality in the Healthy Elderly<\/span><\/p>\n

<\/span><\/p>\n

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\u672c\u6587\u7cfb\u751f\u7269\u63a2\u7d22\u539f\u521b\uff0c\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u5206\u4eab\u3002\u5176\u4ed6\u4efb\u4f55\u5a92\u4f53\u3001\u7f51\u7ad9\u5982\u9700\u8f6c\u8f7d\uff0c\u987b\u5728\u6b63\u6587\u524d\u6ce8\u660e\u6765\u6e90\u751f\u7269\u63a2\u7d22\u3002<\/span><\/p>\n<\/section>\n

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\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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