{"id":50472,"date":"2018-09-23T01:00:00","date_gmt":"2018-09-26T02:09:36","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e3%80%90%e9%87%8d%e8%a6%81%e3%80%91%e6%96%b0%e5%9e%8b%e6%8a%97%e8%82%bf%e7%98%a4%e8%8d%af%e7%89%a9%e4%b8%b4%e5%ba%8a%e5%ba%94%e7%94%a8%e6%8c%87%e5%af%bc%e5%8e%9f%e5%88%99%ef%bc%882018%e5%b9%b4\/"},"modified":"2018-09-26T10:09:37","modified_gmt":"2018-09-26T02:09:37","slug":"%e3%80%90%e9%87%8d%e8%a6%81%e3%80%91%e6%96%b0%e5%9e%8b%e6%8a%97%e8%82%bf%e7%98%a4%e8%8d%af%e7%89%a9%e4%b8%b4%e5%ba%8a%e5%ba%94%e7%94%a8%e6%8c%87%e5%af%bc%e5%8e%9f%e5%88%99%ef%bc%882018%e5%b9%b4","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/50472\/","title":{"rendered":"\u3010\u91cd\u8981\u3011\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09"},"content":{"rendered":"
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<\/section>\n

\"\u3010\u91cd\u8981\u3011\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\"<\/p>\n

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\"\u3010\u91cd\u8981\u3011\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\"<\/section>\n<\/section>\n
\n

\u5173\u4e8e\u5370\u53d1\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\u7684\u901a\u77e5<\/strong><\/span>
<\/p>\n

 \u56fd\u536b\u529e\u533b\u51fd\u30142018\u3015821\u53f7 <\/p>\n


<\/p>\n

\u5404\u7701\u3001\u81ea\u6cbb\u533a\u3001\u76f4\u8f96\u5e02\u53ca\u65b0\u7586\u751f\u4ea7\u5efa\u8bbe\u56e2\u536b\u751f\u8ba1\u751f\u59d4\uff1a <\/p>\n

     \u4e3a\u89c4\u8303\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\uff0c\u6211\u59d4\u7ec4\u7ec7\u539f\u56fd\u5bb6\u536b\u751f\u8ba1\u751f\u59d4\u5408\u7406\u7528\u836f\u4e13\u5bb6\u59d4\u5458\u4f1a\u7275\u5934\u5236\u5b9a\u4e86\u300a\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\u300b\uff08\u53ef\u5728\u6211\u59d4\u5b98\u65b9\u7f51\u7ad9\u201c\u533b\u653f\u533b\u7ba1\u201d\u680f\u76ee\u4e0b\u8f7d\uff09\u3002\u73b0\u5370\u53d1\u4f60\u4eec\uff0c\u8bf7\u8ba4\u771f\u7ec4\u7ec7\u5b66\u4e60\uff0c\u8d2f\u5f7b\u6267\u884c\u3002 <\/p>\n

\u8be5\u6307\u5bfc\u539f\u5219\u5c06\u5b9a\u671f\u4fee\u8ba2\u66f4\u65b0\uff0c\u6307\u5bfc\u4e34\u5e8a\u5408\u7406\u5e94\u7528\u6297\u80bf\u7624\u836f\u7269\u3002 <\/p>\n

\u9644\u4ef6\uff1a\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09<\/span><\/p>\n

2018\u5e749\u670814\u65e5<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\uff08\u4fe1\u606f\u516c\u5f00\u5f62\u5f0f\uff1a\u4e3b\u52a8\u516c\u5f00\uff09<\/span><\/p>\n

\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<\/span><\/strong><\/span><\/p>\n

\uff082018\u5e74\u7248\uff09<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u76ee \u5f55<\/span><\/strong><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u7b2c\u4e00\u90e8\u5206  \u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<\/span><\/strong><\/td>\n<\/tr>\n
\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7684\u57fa\u672c\u539f\u5219<\/strong><\/td>\n
<\/td>\n<\/tr>\n
\u4e00\u3001\u75c5\u7406\u7ec4\u7ec7\u5b66\u786e\u8bca\u540e\u65b9\u53ef\u4f7f\u7528<\/td>\n1<\/td>\n<\/tr>\n
\u4e8c\u3001\u57fa\u56e0\u68c0\u6d4b\u540e\u65b9\u53ef\u4f7f\u7528<\/td>\n2<\/td>\n<\/tr>\n
\u4e09\u3001\u4e25\u683c\u9075\u5faa\u9002\u5e94\u8bc1\u7528\u836f<\/td>\n4<\/td>\n<\/tr>\n
\u56db\u3001\u4f53\u73b0\u60a3\u8005\u6cbb\u7597\u4ef7\u503c<\/span><\/td>\n4<\/td>\n<\/tr>\n
\u4e94\u3001\u7279\u6b8a\u60c5\u51b5\u4e0b\u7684\u836f\u7269\u5408\u7406\u4f7f\u7528<\/td>\n5<\/td>\n<\/tr>\n
\u516d\u3001\u91cd\u89c6\u836f\u7269\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94<\/td>\n5<\/td>\n<\/tr>\n
\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7ba1\u7406<\/strong><\/td>\n
<\/td>\n<\/tr>\n
\u4e00\u3001\u533b\u7597\u673a\u6784\u5efa\u7acb\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7ba1\u7406\u4f53\u7cfb<\/td>\n6<\/td>\n<\/tr>\n
\u4e8c\u3001\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u5b9e\u884c\u5206\u7ea7\u7ba1\u7406<\/td>\n9<\/td>\n<\/tr>\n
\u4e09\u3001\u7ec6\u80de\u6216\u7ec4\u7ec7\u75c5\u7406\u5b66\u8bca\u65ad<\/td>\n10<\/td>\n<\/tr>\n
\u56db\u3001\u57f9\u8bad\u3001\u8bc4\u4f30\u548c\u7763\u67e5<\/td>\n10<\/td>\n<\/tr>\n
\u7b2c\u4e8c\u90e8\u5206  \u5404\u7cfb\u7edf\u80bf\u7624\u7684\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<\/strong><\/td>\n<\/tr>\n
\u547c\u5438\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/strong><\/td>\n
<\/td>\n<\/tr>\n
\u4e00\u3001\u5409\u975e\u66ff\u5c3c<\/td>\n12<\/td>\n<\/tr>\n
\u4e8c\u3001\u5384\u6d1b\u66ff\u5c3c<\/td>\n14<\/td>\n<\/tr>\n
\u4e09\u3001\u57c3\u514b\u66ff\u5c3c<\/td>\n15<\/td>\n<\/tr>\n
\u56db\u3001\u9a6c\u6765\u9178\u963f\u6cd5\u66ff\u5c3c<\/td>\n16<\/td>\n<\/tr>\n
\u4e94\u3001\u5965\u5e0c\u66ff\u5c3c<\/td>\n17<\/td>\n<\/tr>\n
\u516d\u3001\u514b\u5511\u66ff\u5c3c<\/td>\n18<\/td>\n<\/tr>\n
\u4e03\u3001\u8d1d\u4f10\u73e0\u5355\u6297<\/td>\n20<\/td>\n<\/tr>\n
\u516b\u3001\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20<\/td>\n21<\/td>\n<\/tr>\n
\u4e5d\u3001\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c<\/td>\n21<\/td>\n<\/tr>\n
\u5341\u3001\u585e\u745e\u66ff\u5c3c<\/td>\n22<\/td>\n<\/tr>\n
\u5341\u4e00\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/td>\n24<\/td>\n<\/tr>\n
\u6d88\u5316\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/strong><\/td>\n
<\/td>\n<\/tr>\n
\u4e00\u3001\u745e\u6208\u975e\u5c3c<\/td>\n26<\/td>\n<\/tr>\n
\u4e8c\u3001\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c<\/td>\n28<\/td>\n<\/tr>\n
\u4e09\u3001\u66f2\u59a5\u73e0\u5355\u6297<\/td>\n29<\/td>\n<\/tr>\n
\u56db\u3001\u7532\u78fa\u9178\u963f\u5e15\u66ff\u5c3c<\/td>\n29<\/td>\n<\/tr>\n
\u4e94\u3001\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c<\/td>\n30<\/td>\n<\/tr>\n
\u516d\u3001\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c<\/td>\n31<\/td>\n<\/tr>\n
\u4e03\u3001\u4f9d\u7ef4\u83ab\u53f8<\/td>\n32<\/td>\n<\/tr>\n
\u516b\u3001\u8d1d\u4f10\u73e0\u5355\u6297<\/td>\n33<\/td>\n<\/tr>\n
\u4e5d\u3001\u897f\u59a5\u6614\u5355\u6297<\/td>\n35<\/td>\n<\/tr>\n
\u8840\u6db2\u80bf\u7624\u7528\u836f<\/strong><\/td>\n
<\/td>\n<\/tr>\n
\u4e00\u3001\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c<\/td>\n37<\/td>\n<\/tr>\n
\u4e8c\u3001\u8fbe\u6c99\u66ff\u5c3c<\/td>\n39<\/td>\n<\/tr>\n
\u4e09\u3001\u5c3c\u6d1b\u66ff\u5c3c<\/td>\n39<\/td>\n<\/tr>\n
\u56db\u3001\u5229\u59a5\u6614\u5355\u6297<\/td>\n40<\/td>\n<\/tr>\n
\u4e94\u3001\u897f\u8fbe\u672c\u80fa<\/td>\n42<\/td>\n<\/tr>\n
\u516d\u3001\u4f0a\u5e03\u66ff\u5c3c<\/td>\n43<\/td>\n<\/tr>\n
\u4e03\u3001\u787c\u66ff\u4f50\u7c73<\/td>\n45<\/td>\n<\/tr>\n
\u516b\u3001\u6765\u90a3\u5ea6\u80fa<\/td>\n46<\/td>\n<\/tr>\n
\u4e5d\u3001\u6c99\u5229\u5ea6\u80fa<\/td>\n48<\/td>\n<\/tr>\n
\u5341\u3001\u82a6\u53ef\u66ff\u5c3c<\/td>\n49<\/td>\n<\/tr>\n
\u6ccc\u5c3f\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/strong><\/td>\n
<\/td>\n<\/tr>\n
\u4e00\u3001\u4f9d\u7ef4\u83ab\u53f8<\/td>\n50<\/td>\n<\/tr>\n
\u4e8c\u3001\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c<\/td>\n51<\/td>\n<\/tr>\n
\u4e09\u3001\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c<\/td>\n52<\/td>\n<\/tr>\n
\u56db\u3001\u963f\u6614\u66ff\u5c3c<\/td>\n52<\/td>\n<\/tr>\n
\u4e94\u3001\u57f9\u5511\u5e15\u5c3c<\/td>\n53<\/td>\n<\/tr>\n
\u4e73\u817a\u764c\u7528\u836f<\/strong><\/td>\n
<\/td>\n<\/tr>\n
\u4e00\u3001\u66f2\u59a5\u73e0\u5355\u6297<\/td>\n54<\/td>\n<\/tr>\n
\u4e8c\u3001\u7532\u82ef\u78fa\u9178\u62c9\u5e15\u66ff\u5c3c<\/td>\n56<\/td>\n<\/tr>\n
\u76ae\u80a4\u53ca\u8f6f\u7ec4\u7ec7\u80bf\u7624\u7528\u836f<\/strong><\/td>\n
<\/td>\n<\/tr>\n
\u4e00\u3001\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c<\/td>\n58<\/td>\n<\/tr>\n
\u4e8c\u3001\u7ef4\u83ab\u975e\u5c3c<\/td>\n59<\/td>\n<\/tr>\n
\u4e09\u3001\u4f9d\u7ef4\u83ab\u53f8<\/td>\n60<\/td>\n<\/tr>\n
\u5934\u9888\u90e8\u80bf\u7624\u7528\u836f<\/strong><\/td>\n
<\/td>\n<\/tr>\n
\u4e00\u3001\u5c3c\u59a5\u73e0\u5355\u6297<\/td>\n62<\/td>\n<\/tr>\n
\u4e8c\u3001\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c<\/td>\n63<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


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\"\u3010\u91cd\u8981\u3011\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\"<\/section>\n
01<\/span><\/span><\/section>\n
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 <\/span><\/strong><\/span> \u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528<\/span><\/strong><\/span>\u6307\u5bfc\u539f\u5219<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u4e3a\u89c4\u8303\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\uff0c\u63d0\u9ad8\u80bf\u7624\u5408\u7406\u7528\u836f\u6c34\u5e73\uff0c\u4fdd\u969c\u533b\u7597\u8d28\u91cf\u548c\u533b\u7597\u5b89\u5168\uff0c\u7ef4\u62a4\u80bf\u7624\u60a3\u8005\u5065\u5eb7\u6743\u76ca\uff0c\u7279\u5236\u5b9a\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\u3002\u672c\u6307\u5bfc\u539f\u5219\u6d89\u53ca\u7684\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u662f\u6307\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u548c\u5927\u5206\u5b50\u5355\u514b\u9686\u6297\u4f53\u7c7b\u836f\u7269\u3002<\/span><\/p>\n


<\/p>\n

\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7684\u57fa\u672c\u539f\u5219<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u6297\u80bf\u7624\u836f\u7269\u7684\u5e94\u7528\u6d89\u53ca\u4e34\u5e8a\u591a\u4e2a\u5b66\u79d1\uff0c\u5408\u7406\u5e94\u7528\u6297\u80bf\u7624\u836f\u7269\u662f\u63d0\u9ad8\u7597\u6548\u3001\u964d\u4f4e\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u4ee5\u53ca\u5408\u7406\u5229\u7528\u536b\u751f\u8d44\u6e90\u7684\u5173\u952e\u3002\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u9700\u8003\u8651\u836f\u7269\u53ef\u53ca\u6027\u548c\u60a3\u8005\u6cbb\u7597\u4ef7\u503c\u4e24\u5927\u8981\u7d20\u3002\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u662f\u5426\u5408\u7406\uff0c\u57fa\u4e8e\u4ee5\u4e0b\u4e24\u65b9\u9762\uff1a\u6709\u65e0\u6297\u80bf\u7624\u836f\u7269\u5e94\u7528\u6307\u5f81\uff1b\u9009\u7528\u7684\u54c1\u79cd\u53ca\u7ed9\u836f\u65b9\u6848\u662f\u5426\u9002\u5b9c\u3002<\/span><\/p>\n

\u4e00\u3001\u75c5\u7406\u7ec4\u7ec7\u5b66\u786e\u8bca\u540e\u65b9\u53ef\u4f7f\u7528<\/span><\/strong><\/p>\n

\u53ea\u6709\u7ecf\u7ec4\u7ec7\u6216\u7ec6\u80de\u5b66\u75c5\u7406\u786e\u8bca\u3001\u6216\u7279\u6b8a\u5206\u5b50\u75c5\u7406\u8bca\u65ad\u6210\u7acb\u7684\u6076\u6027\u80bf\u7624\uff0c\u624d\u6709\u6307\u5f81\u4f7f\u7528\u6297\u80bf\u7624\u836f\u7269\u3002\u5355\u7eaf\u4f9d\u636e\u60a3\u8005\u7684\u4e34\u5e8a\u75c7\u72b6\u3001\u4f53\u5f81\u548c\u5f71\u50cf\u5b66\u7ed3\u679c\u5f97\u51fa\u4e34\u5e8a\u8bca\u65ad\u7684\u80bf\u7624\u60a3\u8005\uff0c\u6ca1\u6709\u6297\u80bf\u7624\u836f\u7269\u6cbb\u7597\u7684\u6307\u5f81\u3002\u4f46\u662f\uff0c\u5bf9\u4e8e\u67d0\u4e9b\u96be\u4ee5\u83b7\u53d6\u75c5\u7406\u8bca\u65ad\u7684\u80bf\u7624\uff0c\u5982\u80f0\u817a\u764c\uff0c\u5176\u786e\u8bca\u53ef\u53c2\u7167\u56fd\u5bb6\u76f8\u5173\u6307\u5357\u6216\u89c4\u8303\u6267\u884c\u3002<\/span><\/p>\n

\u4e8c\u3001\u57fa\u56e0\u68c0\u6d4b\u540e\u65b9\u53ef\u4f7f\u7528<\/span><\/strong><\/p>\n

\u73b0\u4ee3\u6297\u80bf\u7624\u836f\u7269\u7684\u4e00\u4e2a\u663e\u8457\u7279\u5f81\uff0c\u662f\u51fa\u73b0\u4e00\u6279\u9488\u5bf9\u5206\u5b50\u5f02\u5e38\u7279\u5f81\u7684\u836f\u7269\u2014\u2014\u5373\u9776\u5411\u836f\u7269\u3002\u6700\u5177\u4ee3\u8868\u6027\u7684\u836f\u7269\u662f\u9488\u5bf9\u8868\u76ae\u751f\u957f\u56e0\u5b50\u4fe1\u53f7\u901a\u8def\u5f02\u5e38\u7684\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002\u76ee\u524d\uff0c\u6839\u636e\u662f\u5426\u9700\u8981\u68c0\u6d4b\u751f\u7269\u6807\u5fd7\u7269\uff0c\u53ef\u4ee5\u5c06\u5e38\u7528\u7684\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u548c\u5927\u5206\u5b50\u5355\u514b\u9686\u6297\u4f53\u7c7b\u836f\u7269\u5206\u4e3a\u4e24\u5927\u7c7b\uff08\u88681\uff09\u3002\u5177\u4f53\u7684\u68c0\u6d4b\u751f\u7269\u6807\u8bb0\u7269\u8be6\u89c1\u5404\u7ae0\u8282\u3002<\/span><\/p>\n

\u88681 \u5e38\u7528\u7684\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u548c\u5927\u5206\u5b50\u5355\u514b\u9686\u6297\u4f53\u7c7b\u836f\u7269<\/span><\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u75c5\u79cd<\/span><\/p>\n<\/td>\n

\n

\u9700\u8981\u68c0\u6d4b\u9776\u70b9\u7684\u836f\u7269<\/span><\/p>\n<\/td>\n

\n

\u4e0d\u9700\u8981\u68c0\u6d4b\u9776\u70b9\u7684\u836f\u7269<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u80ba\u764c<\/span><\/p>\n<\/td>\n

\n

\u5409\u975e\u66ff\u5c3c<\/span><\/p>\n

\u5384\u6d1b\u66ff\u5c3c<\/span><\/p>\n

\u57c3\u514b\u66ff\u5c3c<\/span><\/p>\n

\u9a6c\u6765\u9178\u963f\u6cd5\u66ff\u5c3c<\/span><\/p>\n

\u5965\u5e0c\u66ff\u5c3c<\/span><\/p>\n

\u514b\u5511\u66ff\u5c3c<\/span><\/p>\n

\u585e\u745e\u66ff\u5c3c<\/span><\/p>\n

\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/span><\/p>\n<\/td>\n

\n

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\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20<\/span><\/p>\n

\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u809d\u764c<\/span><\/p>\n<\/td>\n


<\/td>\n		\n

\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c<\/span><\/p>\n

\u745e\u6208\u975e\u5c3c<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u80c3\u764c<\/span><\/p>\n<\/td>\n

\n

\u66f2\u59a5\u73e0\u5355\u6297<\/span><\/p>\n<\/td>\n

\n

\u7532\u78fa\u9178\u963f\u5e15\u66ff\u5c3c<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u80c3\u80a0\u9053\u95f4\u8d28\u7624<\/span><\/p>\n<\/td>\n

\n

\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c<\/span><\/p>\n<\/td>\n

\n

\u745e\u6208\u975e\u5c3c<\/span><\/p>\n

\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u80f0\u817a\u795e\u7ecf\u5185\u5206\u6ccc\u7624<\/span><\/p>\n<\/td>\n


<\/td>\n		\n

\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c<\/span><\/p>\n

\u4f9d\u7ef4\u83ab\u53f8<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

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\n

\u897f\u59a5\u6614\u5355\u6297<\/span><\/p>\n<\/td>\n

\n

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\n

\u767d\u8840\u75c5<\/span><\/p>\n<\/td>\n

\n

\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c<\/span><\/p>\n

\u8fbe\u6c99\u66ff\u5c3c<\/span><\/p>\n

\u5c3c\u6d1b\u66ff\u5c3c<\/span><\/p>\n<\/td>\n

\n

\u4f0a\u5e03\u66ff\u5c3c<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u6dcb\u5df4\u7624<\/span><\/p>\n<\/td>\n

\n

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\n

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\u4f0a\u5e03\u66ff\u5c3c<\/span><\/p>\n

\u787c\u66ff\u4f50\u7c73<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/span><\/p>\n<\/td>\n


<\/td>\n		\n

\u787c\u66ff\u4f50\u7c73<\/span><\/p>\n

\u6765\u90a3\u5ea6\u80fa<\/span><\/p>\n

\u6c99\u5229\u5ea6\u80fa<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u9aa8\u9ad3\u589e\u6b96\u6027\u75be\u75c5<\/span><\/p>\n<\/td>\n


<\/td>\n		\n

\u82a6\u53ef\u66ff\u5c3c<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u80be\u764c<\/span><\/p>\n<\/td>\n


<\/td>\n		\n

\u4f9d\u7ef4\u83ab\u53f8<\/span><\/p>\n

\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c<\/span><\/p>\n

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\u963f\u6614\u66ff\u5c3c<\/span><\/p>\n

\u57f9\u5511\u5e15\u5c3c<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

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\n

\u66f2\u59a5\u73e0\u5355\u6297<\/span><\/p>\n

\u7532\u82ef\u78fa\u9178\u62c9\u5e15\u66ff\u5c3c<\/span><\/p>\n<\/td>\n


<\/td>\n<\/tr>\n
\n

\u9ed1\u8272\u7d20\u7624<\/span><\/p>\n


<\/p>\n<\/td>\n

\n

\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c<\/span><\/p>\n

\u7ef4\u83ab\u975e\u5c3c<\/span><\/p>\n<\/td>\n


<\/td>\n<\/tr>\n
\n

\u7ed3\u8282\u6027\u786c\u5316\u75c7\u76f8\u5173\u7684\u5ba4\u7ba1\u819c\u4e0b\u5de8\u7ec6\u80de\u661f\u5f62\u7ec6\u80de\u7624<\/span><\/p>\n<\/td>\n


<\/td>\n		\n

\u4f9d\u7ef4\u83ab\u53f8<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7ed3\u8282\u6027\u786c\u5316\u75c7\u76f8\u5173\u7684\u80be\u8840\u7ba1\u5e73\u6ed1\u808c\u8102\u80aa\u7624<\/span><\/p>\n<\/td>\n


<\/td>\n		\n

\u4f9d\u7ef4\u83ab\u53f8<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u9f3b\u54bd\u764c<\/span><\/p>\n<\/td>\n

\n

\u5c3c\u59a5\u73e0\u5355\u6297<\/span><\/p>\n<\/td>\n


<\/td>\n<\/tr>\n
\n

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<\/td>\n		\n

\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5bf9\u4e8e\u6709\u660e\u786e\u9776\u70b9\u7684\u836f\u7269\uff0c\u987b\u9075\u5faa\u57fa\u56e0\u68c0\u6d4b\u540e\u65b9\u53ef\u4f7f\u7528\u7684\u539f\u5219\u3002\u68c0\u6d4b\u6240\u7528\u7684\u4eea\u5668\u8bbe\u5907\u3001\u8bca\u65ad\u8bd5\u5242\u548c\u68c0\u6d4b\u65b9\u6cd5\u5e94\u5f53\u7ecf\u8fc7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u6279\u51c6\uff0c\u7279\u522b\u662f\u7ecf\u8fc7\u4f34\u968f\u8bca\u65ad\u9a8c\u8bc1\u7684\u65b9\u6cd5\u3002\u4e0d\u5f97\u5728\u672a\u505a\u76f8\u5173\u68c0\u67e5\u7684\u60c5\u51b5\u4e0b\u76f2\u76ee\u7528\u836f\u3002<\/span>
<\/span><\/p>\n

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1.\u666e\u901a\u4f7f\u7528\u7ea7\uff1a\u6709\u660e\u786e\u7684\u4e34\u5e8a\u4f7f\u7528\u9002\u5e94\u8bc1\u3001\u5df2\u5217\u5165\u300a\u56fd\u5bb6\u57fa\u672c\u836f\u7269\u76ee\u5f55\u300b\u300a\u56fd\u5bb6\u57fa\u672c\u533b\u7597\u4fdd\u9669\u836f\u54c1\u76ee\u5f55\u300b\u548c\u56fd\u5bb6\u8c08\u5224\u836f\u54c1\u7684\u6297\u80bf\u7624\u836f\u7269\u54c1\u79cd\u3002<\/span><\/p>\n

2.\u9650\u5236\u4f7f\u7528\u7ea7\uff1a\u6709\u660e\u786e\u7684\u4e34\u5e8a\u4f7f\u7528\u9002\u5e94\u8bc1\u3001\u672a\u5217\u5165\u300a\u56fd\u5bb6\u57fa\u672c\u836f\u7269\u76ee\u5f55\u300b\u6216\u300a\u56fd\u5bb6\u57fa\u672c\u533b\u7597\u4fdd\u9669\u836f\u54c1\u76ee\u5f55\u300b\u6216\u56fd\u5bb6\u8c08\u5224\u836f\u54c1\u7684\u6297\u80bf\u7624\u836f\u7269\u54c1\u79cd\u3002<\/span><\/p>\n

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\u516d\u3001\u91cd\u89c6\u836f\u7269\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94<\/span><\/strong><\/p>\n

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<\/p>\n

\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7ba1\u7406<\/span><\/strong><\/span><\/p>\n


<\/p>\n

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\u4e00\u3001\u533b\u7597\u673a\u6784\u5efa\u7acb\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7ba1\u7406\u4f53\u7cfb<\/span><\/strong><\/p>\n

\u5404\u7ea7\u533b\u7597\u673a\u6784\u5e94\u5f53\u5efa\u7acb\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7ba1\u7406\u4f53\u7cfb\uff0c\u5236\u5b9a\u7b26\u5408\u672c\u673a\u6784\u5b9e\u9645\u60c5\u51b5\u7684\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7ba1\u7406\u5236\u5ea6\uff0c\u660e\u786e\u533b\u7597\u673a\u6784\u8d1f\u8d23\u4eba\u548c\u5404\u804c\u80fd\u90e8\u95e8\u3001\u4e34\u5e8a\u79d1\u5ba4\u8d1f\u8d23\u4eba\u5728\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7ba1\u7406\u4e2d\u7684\u8d23\u4efb\uff0c\u5e76\u5c06\u5176\u7eb3\u5165\u533b\u9662\u8bc4\u5ba1\u8bc4\u4ef7\u3001\u79d1\u5ba4\u7ba1\u7406\u548c\u533b\u7597\u8d28\u91cf\u8bc4\u4f30\u7684\u8003\u6838\u6307\u6807\uff0c\u786e\u4fdd\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7ba1\u7406\u5f97\u5230\u6709\u6548\u5b9e\u65bd\u3002<\/span><\/p>\n

\uff08\u4e00\uff09\u8bbe\u7acb\u6297\u80bf\u7624\u836f\u7269\u7ba1\u7406\u5de5\u4f5c\u7ec4\u3002<\/span><\/strong><\/p>\n

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\uff08\u56db\uff09\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u76d1\u6d4b\u3002<\/span><\/strong><\/p>\n

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\uff08\u4e94\uff09\u4fe1\u606f\u5316\u7ba1\u7406\u3002<\/span><\/strong><\/p>\n

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1.\u6297\u80bf\u7624\u836f\u7269\u7ba1\u7406\u5236\u5ea6\u3001\u4e34\u5e8a\u8bca\u7597\u6307\u5357\u3001\u76d1\u6d4b\u6570\u636e\u7b49\u76f8\u5173\u4fe1\u606f\u7684\u53d1\u5e03\u3002<\/span><\/p>\n

2.\u6297\u80bf\u7624\u836f\u7269\u5408\u7406\u5e94\u7528\u4e0e\u7ba1\u7406\u7684\u7f51\u7edc\u57f9\u8bad\u4e0e\u8003\u6838\u3002<\/span><\/p>\n

3.\u5b9e\u884c\u533b\u5e08\u6297\u80bf\u7624\u836f\u7269\u5904\u65b9\u6743\u9650\u548c\u836f\u5e08\u6297\u80bf\u7624\u836f\u7269\u5904\u65b9\u8c03\u5242\u8d44\u683c\u7ba1\u7406\u3002<\/span><\/p>\n

4.\u5bf9\u5904\u65b9\u533b\u5e08\u63d0\u4f9b\u79d1\u5b66\u7684\u5b9e\u65f6\u66f4\u65b0\u7684\u836f\u54c1\u4fe1\u606f\u3002<\/span><\/p>\n

5.\u901a\u8fc7\u5b9e\u65bd\u7535\u5b50\u5904\u65b9\u7cfb\u7edf\uff0c\u6574\u5408\u60a3\u8005\u75c5\u53f2\u3001\u75c5\u7406\u7ec4\u7ec7\u5b66\u548c\u5206\u5b50\u75c5\u7406\u5b66\u7ed3\u679c\u62a5\u544a\u3001\u5b9e\u9a8c\u5ba4\u8f85\u52a9\u68c0\u67e5\u7ed3\u679c\u3001\u836f\u7269\u5904\u65b9\u4fe1\u606f\u548c\u4e34\u5e8a\u8bca\u6cbb\u6307\u5357\u7b49\u5f62\u6210\u7535\u5b50\u5316\u6297\u80bf\u7624\u836f\u7269\u5904\u65b9\u7cfb\u7edf\uff0c\u6309\u7167\u300a\u5904\u65b9\u7ba1\u7406\u529e\u6cd5\u300b\u548c\u300a\u533b\u7597\u673a\u6784\u5904\u65b9\u5ba1\u6838\u89c4\u8303\u300b\u52a0\u5f3a\u5bf9\u5904\u65b9\u3001\u533b\u5631\u7684\u5ba1\u6838\uff0c\u4fc3\u8fdb\u4e34\u5e8a\u5408\u7406\u7528\u836f\u3002<\/span><\/p>\n

6.\u52a0\u5f3a\u533b\u5631\u7ba1\u7406\uff0c\u5b9e\u73b0\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u5168\u8fc7\u7a0b\u63a7\u5236\u548c\u76d1\u6d4b\uff0c\u505a\u5230\u6297\u80bf\u7624\u836f\u7269\u5904\u65b9\u5f00\u5177\u548c\u6267\u884c\u7684\u52a8\u6001\u76d1\u6d4b\u3002<\/span><\/p>\n

7.\u5b9e\u73b0\u9662\u3001\u79d1\u4e24\u7ea7\u6297\u80bf\u7624\u836f\u7269\u4f7f\u7528\u7387\u3001\u4f7f\u7528\u60c5\u51b5\u3001\u4e0d\u826f\u53cd\u5e94\u62a5\u544a\u7387\u7b49\u6307\u6807\u4fe1\u606f\u5316\u624b\u6bb5\u5b9e\u65f6\u7edf\u8ba1\u3001\u5206\u6790\u3001\u8bc4\u4f30\u548c\u9884\u8b66\u3002<\/span><\/p>\n

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\uff08\u4e00\uff09\u6297\u80bf\u7624\u836f\u7269\u5206\u7ea7\u539f\u5219\u3002<\/span><\/strong><\/p>\n

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1.\u6839\u636e\u672c\u6307\u5bfc\u539f\u5219\uff0c\u4e8c\u7ea7\u4ee5\u4e0a\u533b\u9662\u6309\u5e74\u5ea6\u5bf9\u533b\u5e08\u548c\u836f\u5e08\u8fdb\u884c\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u77e5\u8bc6\u548c\u89c4\u8303\u5316\u7ba1\u7406\u7684\u57f9\u8bad\uff0c\u6309\u4e13\u4e1a\u6280\u672f\u804c\u79f0\u6388\u4e88\u533b\u5e08\u76f8\u5e94\u5904\u65b9\u6743\u548c\u836f\u5e08\u80bf\u7624\u836f\u7269\u5904\u65b9\u8c03\u5242\u8d44\u683c\u3002\u5982\uff0c\u521d\u7ea7\u548c\u4e2d\u7ea7\u804c\u79f0\u7684\u533b\u5e08\u5177\u6709\u666e\u901a\u4f7f\u7528\u7ea7\u6297\u80bf\u7624\u836f\u7269\u7684\u5904\u65b9\u6743\uff0c\u526f\u9ad8\u53ca\u4ee5\u4e0a\u804c\u79f0\u7684\u533b\u5e08\u5177\u6709\u9650\u5236\u4f7f\u7528\u7ea7\u6297\u80bf\u7624\u836f\u7269\u7684\u5904\u65b9\u6743\u3002<\/span><\/p>\n

2.\u9650\u5236\u4f7f\u7528\u7ea7\u6297\u80bf\u7624\u836f\u7269\u7684\u4e34\u5e8a\u5e94\u7528\u5e94\u5f53\u52a0\u4ee5\u63a7\u5236\u3002\u4e34\u5e8a\u5e94\u7528\u9650\u5236\u4f7f\u7528\u7ea7\u6297\u80bf\u7624\u836f\u7269\u5e94\u5f53\u4e25\u683c\u638c\u63e1\u7528\u836f\u6307\u5f81\uff0c\u7531\u5177\u6709\u76f8\u5e94\u5904\u65b9\u6743\u533b\u5e08\u5f00\u5177\u5904\u65b9\uff0c\u540c\u65f6\uff0c\u7531\u5177\u6709\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7ecf\u9a8c\u3001\u5177\u5907\u9ad8\u7ea7\u4e13\u4e1a\u6280\u672f\u804c\u79f0\u4efb\u804c\u8d44\u683c\u7684\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5408\u7406\u5e94\u7528\u4e13\u5bb6\u7ec4\u5ba1\u6838\u540e\u4f7f\u7528\uff0c\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5408\u7406\u5e94\u7528\u4e13\u5bb6\u7ec4\u53ef\u7531\u80bf\u7624\u4e13\u79d1\u533b\u5e08\u3001\u6297\u80bf\u7624\u4e13\u4e1a\u4e34\u5e8a\u836f\u5e08\u3001\u75c5\u7406\u533b\u5e08\u7b49\u7ec4\u6210\u3002\u5982\u7279\u6b8a\u60c5\u51b5\u4e0b\u8d8a\u7ea7\u4f7f\u7528\u4e86\u9650\u5236\u4f7f\u7528\u7ea7\u6297\u80bf\u7624\u836f\u7269\uff0c\u9700\u572824\u5c0f\u65f6\u5185\u8fdb\u884c\u8865\u529e\u624b\u7eed\uff0c\u5e76\u7531\u5177\u5907\u9ad8\u7ea7\u4e13\u4e1a\u6280\u672f\u804c\u79f0\u4efb\u804c\u8d44\u683c\u7684\u533b\u5e08\u5ba1\u6838\u3002<\/span><\/p>\n

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1.\u6839\u636e\u533b\u7597\u673a\u6784\u5b9e\u9645\u60c5\u51b5\u53ca\u5404\u4e34\u5e8a\u79d1\u5ba4\u4e0d\u540c\u4e13\u4e1a\u7279\u70b9\uff0c\u79d1\u5b66\u8bbe\u5b9a\u533b\u9662\u548c\u79d1\u5ba4\u7684\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u63a7\u5236\u6307\u6807\uff0c\u5bf9\u6297\u80bf\u7624\u836f\u7269\u4f7f\u7528\u8d8b\u52bf\u8fdb\u884c\u5206\u6790\u3002<\/span><\/p>\n

2.\u91cd\u89c6\u6297\u80bf\u7624\u836f\u7269\u5904\u65b9\u3001\u533b\u5631\u7684\u4e13\u9879\u70b9\u8bc4\u3002\u6297\u80bf\u7624\u836f\u7269\u7ba1\u7406\u5de5\u4f5c\u7ec4\u5e94\u7ec4\u7ec7\u80bf\u7624\u4e13\u4e1a\u3001\u75c5\u7406\u5b66\u4e13\u4e1a\u548c\u4e34\u5e8a\u836f\u5b66\u7b49\u76f8\u5173\u4e13\u4e1a\u6280\u672f\u4eba\u5458\u7ec4\u6210\u70b9\u8bc4\u5c0f\u7ec4\uff0c\u7ed3\u5408\u533b\u9662\u5b9e\u9645\u60c5\u51b5\u8bbe\u5b9a\u70b9\u8bc4\u76ee\u6807\uff0c\u91cd\u70b9\u5173\u6ce8\u9650\u5236\u4f7f\u7528\u7ea7\u6297\u80bf\u7624\u836f\u7269\u7684\u7528\u836f\u3001\u5404\u79d1\u5ba4\u6297\u80bf\u7624\u836f\u7269\u5e94\u7528\u60c5\u51b5\u4ee5\u53ca\u4e25\u91cd\u548c\u65b0\u7684\u4e0d\u826f\u53cd\u5e94\u62a5\u544a\u60c5\u51b5\u3002<\/span><\/p>\n

\uff08\u4e09\uff09\u53cd\u9988\u4e0e\u5e72\u9884\u3002<\/span><\/strong><\/p>\n

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1.\u6297\u80bf\u7624\u836f\u7269\u7ba1\u7406\u5de5\u4f5c\u7ec4\u5e94\u5f53\u6839\u636e\u5904\u65b9\u70b9\u8bc4\u7ed3\u679c\uff0c\u7814\u7a76\u5236\u5b9a\u5177\u6709\u9488\u5bf9\u6027\u7684\u4e34\u5e8a\u7528\u836f\u8d28\u91cf\u7ba1\u7406\u7b49\u836f\u4e8b\u7ba1\u7406\u6539\u8fdb\u63aa\u65bd\uff0c\u5e76\u8d23\u6210\u76f8\u5173\u90e8\u95e8\u548c\u79d1\u5ba4\u4e88\u4ee5\u843d\u5b9e\u3002<\/span><\/p>\n

2.\u6297\u80bf\u7624\u836f\u7269\u7ba1\u7406\u5de5\u4f5c\u7ec4\u5e94\u5f53\u5bf9\u5b58\u5728\u95ee\u9898\u7684\u76f8\u5173\u79d1\u5ba4\u3001\u4e2a\u4eba\u8fdb\u884c\u91cd\u70b9\u76d1\u6d4b\u4ee5\u8ddf\u8e2a\u5176\u6539\u8fdb\u60c5\u51b5\uff0c\u901a\u8fc7\u201c\u76d1\u6d4b-\u53cd\u9988-\u5e72\u9884-\u8ffd\u8e2a\u201d\u6a21\u5f0f\uff0c\u4fc3\u8fdb\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7684\u6301\u7eed\u6539\u8fdb\u3002<\/span><\/p>\n

\uff08\u56db\uff09\u52a0\u5f3a\u7763\u5bfc\u68c0\u67e5\u3002<\/span><\/strong><\/p>\n

\u536b\u751f\u5065\u5eb7\u884c\u653f\u90e8\u95e8\u5e94\u5f53\u5c06\u533b\u7597\u673a\u6784\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u60c5\u51b5\u7eb3\u5165\u533b\u7597\u673a\u6784\u8003\u6838\u6307\u6807\u4f53\u7cfb\uff1b\u5c06\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u60c5\u51b5\u4f5c\u4e3a\u533b\u7597\u673a\u6784\u5b9a\u7ea7\u3001\u8bc4\u5ba1\u3001\u8bc4\u4ef7\u7684\u91cd\u8981\u6307\u6807\u3002\u5404\u7ea7\u536b\u751f\u5065\u5eb7\u884c\u653f\u90e8\u95e8\u5e94\u5f53\u5efa\u7acb\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u60c5\u51b5\u516c\u5e03\u548c\u8beb\u52c9\u8c08\u8bdd\u5236\u5ea6\uff0c\u5bf9\u672c\u884c\u653f\u533a\u57df\u5185\u533b\u7597\u673a\u6784\u6297\u80bf\u7624\u836f\u7269\u5e94\u7528\u60c5\u51b5\u8fdb\u884c\u76d1\u6d4b\uff0c\u5b9a\u671f\u5411\u672c\u884c\u653f\u533a\u57df\u8fdb\u884c\u793e\u4f1a\u516c\u5e03\uff0c\u5e76\u62a5\u4e0a\u7ea7\u536b\u751f\u5065\u5eb7\u884c\u653f\u90e8\u95e8\u5907\u6848\u3002<\/span><\/p>\n


<\/p>\n

\n
\n
\n
\"\u3010\u91cd\u8981\u3011\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\"<\/section>\n
02<\/span><\/span><\/section>\n
\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u5404\u7cfb\u7edf\u80bf\u7624\u7684\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u547c\u5438\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u4e00\u3001\u5409\u975e\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u5409\u975e\u66ff\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a250mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>EGFR\u57fa\u56e0\u5177\u6709\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684EGFR\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684EGFR\u654f\u611f\u7a81\u53d8\u3002<\/span><\/p>\n

2.\u80bf\u7624\u7ec4\u7ec7\u548c\u8840\u6db2\u5747\u53ef\u7528\u4e8eEGFR\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\uff0c\u4f46\u7ec4\u7ec7\u68c0\u6d4b\u4f18\u5148\u3002<\/span><\/p>\n

3.\u6cbb\u7597\u671f\u95f4\u56e0\u836f\u7269\u6bd2\u6027\u4e0d\u53ef\u8010\u53d7\u65f6\uff0c\u53ef\u5728\u540c\u4e00\u4ee3\u836f\u7269\u4e4b\u95f4\u66ff\u6362\uff0c\u5982\u75be\u75c5\u8fdb\u5c55\u5219\u4e0d\u80fd\u5728\u540c\u4e00\u4ee3\u836f\u7269\u4e4b\u95f4\u66ff\u6362\u3002<\/span><\/p>\n

4.\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5f71\u50cf\u5b66\u663e\u793a\u7f13\u6162\u8fdb\u5c55\u4f46\u4e34\u5e8a\u75c7\u72b6\u672a\u53d1\u751f\u6076\u5316\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\uff1b\u53d1\u751f\u5c40\u90e8\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\u52a0\u5c40\u90e8\u6cbb\u7597\uff1b\u5bf9\u4e8e\u5feb\u901f\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u6539\u6362\u4e3a\u5176\u4ed6\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n

5.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u53cd\u5e94\u548c\u8179\u6cfb\uff1b\u5e94\u7279\u522b\u6ce8\u610f\u95f4\u8d28\u6027\u80ba\u708e\u3001\u809d\u810f\u6bd2\u6027\u548c\u773c\u90e8\u75c7\u72b6\u7684\u53d1\u751f\u3002<\/span><\/p>\n

6.\u907f\u514d\u4e0eCYP3A4\u8bf1\u5bfc\u5242\uff08\u5982\uff0c\u82ef\u59a5\u82f1\u3001\u5361\u9a6c\u897f\u5e73\u3001\u5229\u798f\u5e73\u3001\u5df4\u6bd4\u59a5\u7c7b\u6216\u5723\u7ea6\u7ff0\u8349\uff09\u8054\u5408\u4f7f\u7528\u3002\u907f\u514d\u4e0eCYP3A4\u9176\u6291\u5236\u5242\uff08\u5982\u916e\u5eb7\u5511\u3001\u5f02\u70df\u80bc\uff09\u7b49\u8054\u5408\u4f7f\u7528\uff0c\u5176\u8054\u5408\u4f7f\u7528\u53ef\u80fd\u5bfc\u81f4\u8840\u836f\u6d53\u5ea6\u5347\u9ad8\u800c\u589e\u52a0\u4e0d\u826f\u53cd\u5e94\u3002\u670d\u7528\u534e\u6cd5\u6797\u7684\u60a3\u8005\u5e94\u5b9a\u671f\u76d1\u6d4b\u51dd\u8840\u9176\u539f\u65f6\u95f4\u6216INR\u7684\u6539\u53d8\u3002\u80fd\u663e\u8457\u4e14\u6301\u7eed\u5347\u9ad8\u80c3\u6db2pH\u503c\u7684\u836f\u7269\u6709\u53ef\u80fd\u4f1a\u964d\u4f4e\u5409\u975e\u66ff\u5c3c\u7684\u8840\u836f\u6d53\u5ea6\uff0c\u4ece\u800c\u964d\u4f4e\u5409\u975e\u66ff\u5c3c\u7597\u6548\u3002<\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>7.\u5728\u67d0\u4e9b\u80bf\u7624\u6025\u75c7\u7684\u60c5\u51b5\u4e0b\u5982\u8111\u8f6c\u79fb\u660f\u8ff7\u6216\u547c\u5438\u8870\u7aed\uff0c\u5728\u5145\u5206\u77e5\u60c5\u7684\u60c5\u51b5\u4e0b\uff0c\u5bf9\u4e0d\u5438\u70df\u7684\u80ba\u817a\u764c\u60a3\u8005\u53ef\u8003\u8651\u4f7f\u7528\u3002\u4e00\u65e6\u75c5\u60c5\u7f13\u89e3\uff0c\u5fc5\u987b\u8865\u5145\u8fdb\u884cEGFR\u7a81\u53d8\u7684\u7ec4\u7ec7\u68c0\u6d4b\u3002<\/span><\/span><\/span><\/p>\n

                                                                    <\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>\u6ce8\uff1a\u672c\u6307\u5bfc\u539f\u5219\u201c\u5408\u7406\u7528\u836f\u8981\u70b9\u201d\u5e26\u203b<\/sup>\u90e8\u5206\u4e3a\u7279\u6b8a\u60c5\u51b5\u4e0b\u7684\u836f\u7269\u5408\u7406\u4f7f\u7528\u4e13\u5bb6\u5171\u8bc6\u3002<\/span><\/strong><\/span><\/p>\n

\u4e8c\u3001\u5384\u6d1b\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u76d0\u9178\u5384\u6d1b\u66ff\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a150mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>EGFR\u57fa\u56e0\u5177\u6709\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u5384\u6d1b\u66ff\u5c3c\u4e00\u7ebf\u6216\u7ef4\u6301\u4f7f\u7528\u4e8e\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u7684\u6cbb\u7597\u65f6\uff0c\u5fc5\u987b\u5bf9\u60a3\u8005\u7684EGFR\u7a81\u53d8\u8fdb\u884c\u8bc4\u4f30\uff0c\u9009\u7528\u7ecf\u8fc7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u654f\u611f\u7a81\u53d8\u3002<\/span><\/p>\n

2.\u6709\u8111\u8f6c\u79fb\u7684EGFR\u57fa\u56e0\u7a81\u53d8\u7684NSCLC\u60a3\u8005\u53ef\u8003\u8651\u4f7f\u7528\u5384\u6d1b\u66ff\u5c3c\u3002<\/span><\/p>\n

3.\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5f71\u50cf\u5b66\u663e\u793a\u7f13\u6162\u8fdb\u5c55\u4f46\u4e34\u5e8a\u75c7\u72b6\u672a\u53d1\u751f\u6076\u5316\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\uff1b\u53d1\u751f\u5c40\u90e8\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\u52a0\u5c40\u90e8\u6cbb\u7597\uff1b\u5bf9\u4e8e\u5feb\u901f\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u6539\u6362\u4e3a\u5176\u4ed6\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n

4.CYP3A4\u6291\u5236\u5242\u4f1a\u4f7f\u5176\u66b4\u9732\u589e\u52a0\u3002\u540c\u65f6CYP3A4\u8bf1\u5bfc\u5242\u5982\u5229\u798f\u5e73\u4e5f\u5e94\u907f\u514d\u4f7f\u7528\uff0c\u82e5\u4f7f\u7528\u65f6\u53ef\u8003\u8651\u589e\u52a0\u5384\u6d1b\u66ff\u5c3c\u5242\u91cf\u3002<\/span><\/p>\n

5.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u53cd\u5e94\u548c\u8179\u6cfb\u3002\u5e94\u7279\u522b\u6ce8\u610f\u95f4\u8d28\u6027\u80ba\u708e\u3001\u809d\u529f\u80fd\u5f02\u5e38\u548c\u773c\u90e8\u75c7\u72b6\u7684\u53d1\u751f\u3002<\/span><\/p>\n

6.\u5438\u70df\u4f1a\u5bfc\u81f4\u5384\u6d1b\u66ff\u5c3c\u7684\u66b4\u9732\u91cf\u964d\u4f4e\uff0c\u5efa\u8bae\u60a3\u8005\u6212\u70df\u3002<\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>7.\u5728\u67d0\u4e9b\u80bf\u7624\u6025\u75c7\u7684\u60c5\u51b5\u4e0b\u5982\u8111\u8f6c\u79fb\u660f\u8ff7\u6216\u547c\u5438\u8870\u7aed\uff0c\u5728\u5145\u5206\u77e5\u60c5\u7684\u60c5\u51b5\u4e0b\uff0c\u5bf9\u4e0d\u5438\u70df\u7684\u80ba\u817a\u764c\u60a3\u8005\u53ef\u8003\u8651\u4f7f\u7528\u3002\u4e00\u65e6\u75c5\u60c5\u7f13\u89e3\uff0c\u5fc5\u987b\u8865\u5145\u8fdb\u884cEGFR\u7a81\u53d8\u7684\u7ec4\u7ec7\u68c0\u6d4b\u3002<\/span><\/span><\/p>\n

\u4e09\u3001\u57c3\u514b\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u76d0\u9178\u57c3\u514b\u66ff\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a125mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>EGFR\u57fa\u56e0\u5177\u6709\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u9488\u5bf9\u4e00\u7ebf\u6cbb\u7597\uff0c\u7528\u836f\u524d\u8fdb\u884cEGFR\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\uff0c\u7ec4\u7ec7\u548c\u6db2\u4f53\u68c0\u6d4b\u5747\u53ef\uff0c\u7ec4\u7ec7\u68c0\u6d4b\u4f18\u5148\u3002<\/span><\/p>\n

2.\u6709\u8111\u8f6c\u79fb\u7684EGFR\u57fa\u56e0\u7a81\u53d8\u7684NSCLC\u60a3\u8005\uff0c\u53ef\u4f18\u5148\u9009\u62e9\u57c3\u514b\u66ff\u5c3c\u3002<\/span><\/p>\n

3.\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5f71\u50cf\u5b66\u663e\u793a\u7f13\u6162\u8fdb\u5c55\u4f46\u4e34\u5e8a\u75c7\u72b6\u672a\u53d1\u751f\u6076\u5316\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\uff1b\u53d1\u751f\u5c40\u90e8\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\u52a0\u5c40\u90e8\u6cbb\u7597\uff1b\u5bf9\u4e8e\u5feb\u901f\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u6539\u6362\u4e3a\u5176\u4ed6\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n

4.\u4e00\u7ebf\u63a5\u53d7\u5316\u7597\u5931\u8d25\u7684\u60a3\u8005\uff0c\u4e8c\u3001\u4e09\u7ebf\u53ef\u8003\u8651\u4f7f\u7528\u57c3\u514b\u66ff\u5c3c\uff0c\u4f46\u4e0d\u63a8\u8350\u7528\u4e8eEGFR\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u7684\u60a3\u8005\u3002<\/span><\/p>\n

5.\u4e0d\u826f\u53cd\u5e94\u4e3b\u8981\u4e3a\u5e38\u89c1\u7684I\u3001\u2161\u5ea6\u76ae\u75b9\u548c\u8179\u6cfb\uff0c\u5e94\u7279\u522b\u5173\u6ce8\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\u3002<\/span><\/p>\n

6.\u57c3\u514b\u66ff\u5c3c\u4e3b\u8981\u901a\u8fc7\u7ec6\u80de\u8272\u7d20P-450\u5355\u52a0\u6c27\u9176\u7cfb\u7edf\u7684CYP2C19\u548cCYP3A4\u4ee3\u8c22\uff0c\u5bf9CYP2C9\u548cCYP3A4\u6709\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528\u3002<\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>7. \u5728\u67d0\u4e9b\u80bf\u7624\u6025\u75c7\u7684\u60c5\u51b5\u4e0b\u5982\u8111\u8f6c\u79fb\u660f\u8ff7\u6216\u547c\u5438\u8870\u7aed\uff0c\u5982\u679c\u8840\u6db2\u68c0\u6d4bEGFR\u57fa\u56e0\u7a81\u53d8\u4ecd\u4e3a\u9634\u6027\uff0c\u5728\u5145\u5206\u77e5\u60c5\u7684\u60c5\u51b5\u4e0b\uff0c\u5bf9\u4e0d\u5438\u70df\u7684\u80ba\u817a\u764c\u53ef\u8003\u8651\u4f7f\u7528\u3002\u4e00\u65e6\u75c5\u60c5\u7f13\u89e3\uff0c\u5fc5\u987b\u8865\u5145\u8fdb\u884cEGFR\u57fa\u56e0\u7a81\u53d8\u7684\u7ec4\u7ec7\u68c0\u6d4b\u3002<\/span><\/span><\/p>\n

\u56db\u3001\u9a6c\u6765\u9178\u963f\u6cd5\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u9a6c\u6765\u9178\u963f\u6cd5\u66ff\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a30mg\u300140mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u5177\u6709EGFR\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\uff0c\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09\u6cbb\u7597\u3002<\/span><\/p>\n

2.\u542b\u94c2\u5316\u7597\u671f\u95f4\u6216\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u7ec4\u7ec7\u5b66\u7c7b\u578b\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3002<\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u4e00\u7ebf\u6cbb\u7597EGFR\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u7684\u665a\u671fNSCLC\u60a3\u8005\uff0c\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684EGFR\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684EGFR\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u3002\u80bf\u7624\u7ec4\u7ec7\u548c\u8840\u6db2\u5747\u53ef\u7528\u4e8eEGFR\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\uff0c\u4f46\u7ec4\u7ec7\u68c0\u6d4b\u4f18\u5148\u3002<\/span><\/p>\n

2.\u867d\u7136\u836f\u54c1\u8bf4\u660e\u4e66\u663e\u793a\u9a6c\u6765\u9178\u963f\u6cd5\u66ff\u5c3c\u4e0d\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u53ef\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u542b\u94c2\u5316\u7597\u671f\u95f4\u6216\u5316\u7597\u540e\u8fdb\u5c55\u7684\u665a\u671f\u80ba\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\uff0c\u4f46\u4ecd\u7136\u4e0d\u63a8\u8350\u7528\u4e8eEGFR\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u7684\u60a3\u8005\u3002<\/span><\/p>\n

3.\u5bf9\u4e8e\u975e\u5e38\u89c1EGFR\u57fa\u56e0\u7a81\u53d8\u60a3\u8005\uff0c\u4f18\u5148\u4f7f\u7528\u9a6c\u6765\u9178\u963f\u6cd5\u66ff\u5c3c\u3002<\/span><\/p>\n

4.\u63a8\u8350\u5242\u91cf\u4e3a40mg\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u53ef\u6839\u636e\u60a3\u8005\u8010\u53d7\u6027\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff0c\u5242\u91cf\u8c03\u6574\u65b9\u6848\u89c1\u88682\u3002<\/span><\/p>\n

5.\u5bf9\u4e8e\u5e74\u8001\u4f53\u5f31\u60a3\u8005\uff0c\u53ef\u4f7f\u752830mg\u4f5c\u4e3a\u63a8\u8350\u5242\u91cf\u3002<\/span><\/p>\n

6.\u9a6c\u6765\u9178\u963f\u6cd5\u66ff\u5c3c\u4e0d\u5e94\u4e0e\u98df\u7269\u540c\u670d\uff0c\u5e94\u5f53\u5728\u8fdb\u98df\u540e\u81f3\u5c113\u5c0f\u65f6\u6216\u8fdb\u98df\u524d\u81f3\u5c111\u5c0f\u65f6\u670d\u7528\u3002<\/span><\/p>\n

7.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u8179\u6cfb\u3001\u76ae\u80a4\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u3001\u95f4\u8d28\u6027\u80ba\u708e\u7b49\u4e0d\u826f\u4e8b\u4ef6\u3002<\/span><\/p>\n

8.\u5982\u9700\u8981\u4f7f\u7528P-\u7cd6\u5316\u86cb\u767d\uff08P-gp\uff09\u6291\u5236\u5242\uff0c\u5e94\u91c7\u7528\u4ea4\u9519\u5242\u91cf\u7ed9\u836f\uff0c\u5c3d\u53ef\u80fd\u5ef6\u957f\u4e0e\u9a6c\u6765\u9178\u963f\u6cd5\u66ff\u5c3c\u7ed9\u836f\u7684\u95f4\u9694\u65f6\u95f4\u3002<\/span><\/p>\n

\u88682 \u9a6c\u6765\u9178\u963f\u6cd5\u66ff\u5c3c\u63a8\u8350\u5242\u91cf\u8c03\u6574\u65b9\u6848<\/span><\/strong><\/p>\n\n\n\n\n\n
\n

CTCAEa<\/span><\/strong>\u836f\u7269\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u9a6c\u6765\u9178\u963f\u6cd5\u66ff\u5c3c\u7684\u5efa\u8bae\u7ed9\u836f\u91cf<\/span><\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1\u7ea7\u62162\u7ea7<\/span><\/p>\n<\/td>\n

\n

\u4e0d\u4e2d\u65adb<\/sup><\/span><\/p>\n<\/td>\n

\n

\u4e0d\u8c03\u6574\u5242\u91cf<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2\u7ea7\uff08\u5ef6\u957fc<\/sup>\u6216\u4e0d\u8010\u53d7\uff09\u6216\u22653\u7ea7<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u65ad\u76f4\u5230\u6062\u590d\u81f30\/1\u7ea7b<\/sup><\/span><\/p>\n<\/td>\n

\n

\u4ee5\u51cf\u91cf10mg\u9012\u51cf\u7ee7\u7eedd<\/sup><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

a<\/span><\/sup>\u7f8e\u56fd\u56fd\u7acb\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u4e0d\u826f\u4e8b\u4ef6\u901a\u7528\u672f\u8bed\u6807\u51c63.0\u7248\u3002<\/span><\/span><\/p>\n

b<\/span><\/sup>\u53d1\u751f\u8179\u6cfb\u65f6\uff0c\u5e94\u7acb\u5373\u4f7f\u7528\u6297\u8179\u6cfb\u836f\u7269\uff08\u5982\u6d1b\u54cc\u4e01\u80fa\uff09\uff0c\u5e76\u4e14\u5bf9\u4e8e\u6301\u7eed\u8179\u6cfb\u7684\u60c5\u51b5\u5e94\u7ee7\u7eed\u7528\u836f\u76f4\u5230\u8179\u6cfb\u505c\u6b62\u3002<\/span><\/span><\/p>\n

c<\/span><\/sup>\u8179\u6cfb\uff1e48\u5c0f\u65f6\u548c\/\u6216\u76ae\u75b9\uff1e7\u5929\u3002<\/span><\/span><\/p>\n

d<\/span><\/sup>\u5982\u679c\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\u6bcf\u592920mg\uff0c\u5e94\u8003\u8651\u6c38\u4e45\u505c\u7528\u672c\u54c1\u3002<\/span><\/span><\/p>\n

\u4e94\u3001\u5965\u5e0c\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d<\/span><\/strong>\uff1a<\/span><\/strong>\u7532\u78fa\u9178<\/span>\u5965\u5e0c\u66ff\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a40mg\u300180mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u672c\u54c1\u9002\u7528\u4e8e\u65e2\u5f80\u7ecfEGFR-TKI\u6cbb\u7597\u65f6\u6216\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u5e76\u4e14\u7ecf\u68c0\u6d4b\u786e\u8ba4\u5b58\u5728EGFR-T790M\u7a81\u53d8\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230EGFR-T790M\u7a81\u53d8\u3002<\/span><\/p>\n

2.\u80bf\u7624\u7ec4\u7ec7\u548c\u8840\u6db2\u5747\u53ef\u7528\u4e8eT790M\u7a81\u53d8\u68c0\u6d4b\uff0c\u4f46\u7ec4\u7ec7\u68c0\u6d4b\u4f18\u5148\u3002EGFR\u7a81\u53d8\u7684\u8111\u8f6c\u79fb\u60a3\u8005\u63a8\u8350\u4f18\u5148\u4f7f\u7528\u3002<\/span><\/p>\n

3.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u53cd\u5e94\u548c\u8179\u6cfb\uff0c\u5e94\u7279\u522b\u6ce8\u610f\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\u3002<\/span><\/p>\n

4.\u907f\u514d\u4e0eCYP3A4\u8bf1\u5bfc\u5242\uff08\u5982\uff0c\u82ef\u59a5\u82f1\u3001\u5361\u9a6c\u897f\u5e73\u3001\u5229\u798f\u5e73\u3001\u5df4\u6bd4\u59a5\u7c7b\u6216\u5723\u7ea6\u7ff0\u8349\uff09\u8054\u5408\u4f7f\u7528\u3002<\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>5.\u5728\u67d0\u4e9b\u80bf\u7624\u6025\u75c7\u7684\u60c5\u51b5\u4e0b\u5982\u8111\u8f6c\u79fb\u660f\u8ff7\u6216\u547c\u5438\u8870\u7aed\uff0c\u5982\u679c\u8840\u6db2\u68c0\u6d4bT790M\u4ecd\u4e3a\u9634\u6027\uff0c\u5728\u5145\u5206\u77e5\u60c5\u7684\u60c5\u51b5\u4e0b\uff0c\u53ef\u8003\u8651\u4f7f\u7528\u3002\u4e00\u65e6\u75c5\u60c5\u7f13\u89e3\uff0c\u5fc5\u987b\u8865\u5145\u8fdb\u884cEGFR\u7a81\u53d8\u7684\u7ec4\u7ec7\u68c0\u6d4b\u3002<\/span><\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>6.\u786e\u8ba4\u8111\u819c\u8f6c\u79fb\u7684\u60a3\u8005\uff0c\u4e14T790M\u68c0\u6d4b\u4e3a\u9634\u6027\uff0c\u5728\u5145\u5206\u77e5\u60c5\u7684\u60c5\u51b5\u4e0b\uff0c\u53ef\u8003\u8651\u4f7f\u7528\u3002<\/span><\/span><\/p>\n

\u516d\u3001\u514b\u5511\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d<\/span><\/strong>\uff1a<\/span><\/strong>\u514b\u5511\u66ff\u5c3c\u80f6\u56ca<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u80f6\u56ca\uff1a200mg\u3001250mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

2.ROS1\u9633\u6027\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684ROS1\u6216ALK\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684ROS1\u9633\u6027\u6216\u8005ALK\u9633\u6027\u3002<\/span><\/p>\n

2. \u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5f71\u50cf\u5b66\u663e\u793a\u7f13\u6162\u8fdb\u5c55\u4f46\u4e34\u5e8a\u75c7\u72b6\u672a\u53d1\u751f\u6076\u5316\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\uff1b\u53d1\u751f\u5c40\u90e8\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\u52a0\u5c40\u90e8\u6cbb\u7597\uff1b\u5bf9\u4e8e\u5feb\u901f\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u6539\u6362\u4e3a\u5176\u4ed6\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n

3.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u809d\u529f\u80fd\u5f02\u5e38\u548c\u89c6\u89c9\u5f02\u5e38\uff0c\u5728\u6cbb\u7597\u5f00\u59cb\u7684\u6700\u521d\u4e24\u4e2a\u6708\u5e94\u6bcf\u5468\u68c0\u6d4b\u4e00\u6b21\uff0c\u4e4b\u540e\u6bcf\u6708\u68c0\u6d4b\u4e00\u6b21\u60a3\u8005\u7684\u809d\u529f\u80fd\uff0c\u4e25\u91cd\u809d\u635f\u4f24\u60a3\u8005\u7981\u7528\u3002<\/span><\/p>\n

4.\u5982\u679c\u60a3\u8005\u51fa\u73b0\u7f8e\u56fd\u56fd\u7acb\u764c\u75c7\u7814\u7a76\u6240\u4e0d\u826f\u4e8b\u4ef6\u901a\u7528\u672f\u8bed\u6807\u51c6\uff08NCICTCAE\uff0c\u7b2c4.0\u7248\uff09\u89c4\u5b9a\u7684\u4e25\u91cd\u7a0b\u5ea6\u4e3a3\u7ea7\u62164\u7ea7\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u9700\u4e00\u6b21\u6216\u591a\u6b21\u51cf\u5c11\u5242\u91cf\uff0c\u6309\u4ee5\u4e0b\u65b9\u6cd5\u51cf\u5c11\u5242\u91cf\uff1a\uff081\uff09\u7b2c\u4e00\u6b21\u51cf\u5c11\u5242\u91cf\uff1a\u53e3\u670d\uff0c200mg\uff0c\u6bcf\u65e5\u4e24\u6b21\uff1b\uff082\uff09\u7b2c\u4e8c\u6b21\u51cf\u5c11\u5242\u91cf\uff1a\u53e3\u670d\uff0c250mg\uff0c\u6bcf\u65e5\u4e00\u6b21\uff1b\u5982\u679c\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d250mg\u514b\u5511\u66ff\u5c3c\u80f6\u56ca\u4ecd\u65e0\u6cd5\u8010\u53d7\uff0c\u5219\u6c38\u4e45\u505c\u670d\u3002<\/span><\/p>\n

5.\u76ee\u524dCYP3A\u6291\u5236\u5242\u5bf9\u7a33\u6001\u514b\u5511\u66ff\u5c3c\u66b4\u9732\u91cf\u5f71\u54cd\u7a0b\u5ea6\u5c1a\u4e0d\u786e\u5b9a\u3002\u514b\u5511\u66ff\u5c3c\u662f\u4e00\u79cdCYP3A\u7684\u4e2d\u5ea6\u6291\u5236\u5242\u3002\u4f53\u5916\u7814\u7a76\u8868\u660e\uff0c\u5c3d\u7ba1\u514b\u5511\u66ff\u5c3c\u662fCYP2B6\u5e95\u7269\u4ee3\u8c22\u7684\u4ecb\u5bfc\u6291\u5236\u5242\uff0c\u4f46\u5728\u4e34\u5e8a\u4e0a\u4e0d\u4f1a\u53d1\u751f\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3002<\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>6.\u7528\u4e8ecMET14\u5916\u663e\u5b50\u8df3\u8dc3\u7a81\u53d8\u7684\u665a\u671fNSCLC\u60a3\u8005\u3002<\/span><\/span><\/p>\n

\u4e03\u3001<\/span>\u8d1d\u4f10\u73e0\u5355\u6297<\/span><\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u8d1d\u4f10\u73e0\u5355\u6297\u6ce8\u5c04\u6db2<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u9488\u5242\uff1a100mg\uff084ml\uff09\/\u74f6\u3001400mg\uff0816ml\uff09\/\u74f6<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u5361\u94c2\u4e0e\u7d2b\u6749\u9187\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u665a\u671f\u3001\u8f6c\u79fb\u6027\u6216\u590d\u53d1\u6027\u975e\u9cde\u72b6\u7ec6\u80deNSCLC\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u8d1d\u4f10\u73e0\u5355\u6297\u4e0d\u9002\u7528\u4e8e\u665a\u671f\u80ba\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

2.\u6709\u4e25\u91cd\u51fa\u8840\u6216\u8005\u8fd1\u671f\u66fe\u6709\u54af\u8840\u3001\u80bf\u7624\u4fb5\u72af\u5927\u8840\u7ba1\u7684\u60a3\u8005\u4e0d\u5e94\u63a5\u53d7\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u3002<\/span><\/p>\n

3.\u8d1d\u4f10\u73e0\u5355\u6297\u4e0e\u5361\u94c2\u548c\u7d2b\u6749\u9187\u8054\u5408\u7528\u836f\u6700\u591a6\u4e2a\u5468\u671f\uff0c\u968f\u540e\u7ed9\u4e88\u8d1d\u4f10\u73e0\u5355\u6297\u5355\u836f\u6cbb\u7597\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u76ee\u524d\u9664\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u5361\u94c2\/\u7d2b\u6749\u9187\u4e00\u7ebf\u6cbb\u7597\u5916\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u94c2\u7c7b\/\u57f9\u7f8e\u66f2\u585e\u4e00\u7ebf\u6cbb\u7597\u4e5f\u6709\u90e8\u5206\u5faa\u8bc1\u4f9d\u636e\u3002<\/span><\/p>\n

4.\u8d1d\u4f10\u73e0\u5355\u6297\u63a8\u8350\u5242\u91cf\u4e3a15mg\/kg\uff0c\u6bcf3\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u4e5f\u53ef\u4ee5\u4f7f\u75287.5mg\/kg\uff0c\u6bcf3\u5468\u7ed9\u836f\u4e00\u6b21\u3002<\/span><\/p>\n

5.\u51fa\u73b0\u4ee5\u4e0b\u60c5\u51b5\uff0c\u505c\u6b62\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\uff1a\uff081\uff09\u80c3\u80a0\u9053\u7a7f\u5b54\uff08\u80c3\u80a0\u9053\u7a7f\u5b54\u3001\u80c3\u80a0\u9053\u7618\u5f62\u6210\u3001\u8179\u8154\u8113\u80bf\uff09\uff0c\u5185\u810f\u7618\u5f62\u6210\u3002\uff082\uff09\u9700\u8981\u5e72\u9884\u6cbb\u7597\u7684\u4f24\u53e3\u88c2\u5f00\u4ee5\u53ca\u4f24\u53e3\u6108\u5408\u5e76\u53d1\u75c7\u3002\uff083\uff09\u91cd\u5ea6\u51fa\u8840\uff08\u4f8b\u5982\u9700\u8981\u5e72\u9884\u6cbb\u7597\uff09\u3002\uff084\uff09\u91cd\u5ea6\u52a8\u8109\u8840\u6813\u4e8b\u4ef6\u3002\uff085\uff09\u5371\u53ca\u751f\u547d\uff084\u7ea7\uff09\u7684\u9759\u8109\u8840\u6813\u6813\u585e\u4e8b\u4ef6\uff0c\u5305\u62ec\u80ba\u6813\u585e\u3002\uff086\uff09\u9ad8\u8840\u538b\u5371\u8c61\u6216\u9ad8\u8840\u538b\u8111\u75c5\u3002\uff087\uff09\u53ef\u9006\u6027\u540e\u90e8\u8111\u75c5\u7efc\u5408\u5f81\uff08PRES\uff09\u3002\uff088\uff09\u80be\u75c5\u7efc\u5408\u5f81\u3002<\/span><\/p>\n

6.\u5982\u679c\u51fa\u73b0\u4ee5\u4e0b\u72b6\u51b5\uff0c\u9700\u6682\u505c\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\uff1a\uff081\uff09\u62e9\u671f\u624b\u672f\u524d4\uff5e6\u5468\u3002\uff082\uff09\u836f\u7269\u63a7\u5236\u4e0d\u826f\u7684\u91cd\u5ea6\u9ad8\u8840\u538b\u3002\uff083\uff09\u4e2d\u5ea6\u5230\u91cd\u5ea6\u7684\u86cb\u767d\u5c3f\u9700\u8981\u8fdb\u4e00\u6b65\u8bc4\u4f30\u3002\uff084\uff09\u91cd\u5ea6\u8f93\u6db2\u53cd\u5e94\u3002<\/span><\/p>\n

\u516b\u3001\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20\u6ce8\u5c04\u6db2<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u9488\u5242\uff1a15mg\uff083ml\uff09\/\u74f6<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u672c\u54c1\u8054\u5408NP\u5316\u7597\u65b9\u6848\u7528\u4e8e\u6cbb\u7597\u521d\u6cbb\u6216\u590d\u6cbb\u7684\u2162\uff5e\u2163\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u8fc7\u654f\u4f53\u8d28\u6216\u5bf9\u86cb\u767d\u7c7b\u751f\u7269\u5236\u54c1\u6709\u8fc7\u654f\u53f2\u8005\u614e\u7528\u3002<\/span><\/p>\n

2.\u6709\u4e25\u91cd\u5fc3\u810f\u75c5\u6216\u75c5\u53f2\u8005\u614e\u7528\uff0c\u672c\u54c1\u4e34\u5e8a\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u5e94\u5b9a\u671f\u68c0\u6d4b\u5fc3\u7535\u56fe\u3002<\/span><\/p>\n

3.\u672c\u54c1\u9002\u7528\u4e8e\u521d\u6cbb\u6216\u590d\u6cbb\u7684\u2162\uff5e\u2163\u671fNSCLC\u60a3\u8005\uff0c\u76ee\u524d\u6ca1\u6709\u5faa\u8bc1\u8bc1\u636e\u652f\u6301\u672c\u54c1\u7528\u4e8e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

\u4e5d\u3001\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d<\/span><\/strong>\uff1a<\/span><\/strong>\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c\u80f6\u56ca<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u80f6\u56ca\uff1a8mg\u300110mg\u300112mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u672c\u54c1\u5355\u836f\u9002\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc72\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u51fa\u73b0\u8fdb\u5c55\u6216\u590d\u53d1\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u6cbb\u7597\u3002\u5bf9\u4e8e\u5b58\u5728EGFR\u57fa\u56e0\u7a81\u53d8\u6216\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9633\u6027\u7684\u60a3\u8005\uff0c\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u5e94\u63a5\u53d7\u76f8\u5e94\u7684\u9776\u5411\u836f\u7269\u6cbb\u7597\u540e\u8fdb\u5c55\u3001\u4e14\u81f3\u5c11\u63a5\u53d7\u8fc72\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u51fa\u73b0\u8fdb\u5c55\u6216\u590d\u53d1\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u4f7f\u7528\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c\u524d\u65e0\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\uff0c\u4f46\u5bf9\u4e8e\u5b58\u5728EGFR\u57fa\u56e0\u7a81\u53d8\u6216ALK\u878d\u5408\u9633\u6027\u7684\u60a3\u8005\uff0c\u5728\u5f00\u59cb\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u524d\u5e94\u63a5\u53d7\u76f8\u5e94\u7684\u6807\u51c6\u9776\u5411\u836f\u7269\u6cbb\u7597\u540e\u8fdb\u5c55\u3001\u4e14\u81f3\u5c11\u63a5\u53d7\u8fc72\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u51fa\u73b0\u8fdb\u5c55\u6216\u590d\u53d1\u3002<\/span><\/p>\n

2.\u4e2d\u592e\u578b\u80ba\u9cde\u72b6\u7ec6\u80de\u764c\u6216\u5177\u6709\u5927\u54af\u8840\u98ce\u9669\u7684\u60a3\u8005\u7981\u7528\u3002<\/span><\/p>\n

3.\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c\u6709\u589e\u52a0\u53d1\u751f\u51fa\u8840\u4e8b\u4ef6\u548c\u53d1\u751f\u8840\u6813\/\u6813\u585e\u4e8b\u4ef6\u7684\u98ce\u9669\uff0c\u56e0\u6b64\u5177\u6709\u51fa\u8840\u98ce\u9669\u3001\u51dd\u8840\u529f\u80fd\u5f02\u5e38\u7684\u60a3\u8005\u3001\u5177\u6709\u8840\u6813\/\u5352\u4e2d\u75c5\u53f2\u7684\u60a3\u8005\u4ee5\u53ca\u670d\u7528\u6297\u51dd\u836f\u7269\u53ca\u76f8\u5173\u75be\u75c5\u7684\u60a3\u8005\u5e94\u614e\u7528\u3002<\/span><\/p>\n

4.\u8001\u5e74\u60a3\u8005\uff0865\u5c81\u4ee5\u4e0a\uff09\u4f7f\u7528\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c\u65f6\uff0c\u65e0\u9700\u8c03\u6574\u7528\u836f\u5242\u91cf\u3002<\/span><\/p>\n

5.\u7528\u836f\u671f\u95f4\u5e94\u5bc6\u5207\u5173\u6ce8\u9ad8\u8840\u538b\u7684\u53d1\u751f\uff0c\u5e38\u89c4\u964d\u538b\u836f\u7269\u53ef\u6709\u6548\u63a7\u5236\u60a3\u8005\u8840\u538b\u3002<\/span><\/p>\n

6.\u907f\u514d\u4e0eCYP1A2\u548cCYP3A4\u7684\u6291\u5236\u5242\u548c\u8bf1\u5bfc\u5242\u8054\u7528\uff0c\u5982\u5229\u798f\u5e73\u3001\u5730\u585e\u7c73\u677e\u3001\u514b\u62c9\u9709\u7d20\u3001\u916e\u5eb7\u5511\u7b49\u3002<\/span><\/p>\n

\u5341\u3001\u585e\u745e\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d<\/span><\/strong>\uff1a<\/span><\/strong>\u585e\u745e\u66ff\u5c3c\u80f6\u56ca<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/strong>\uff1a<\/span><\/strong>\u80f6\u56ca\uff1a150mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u672c\u54c1\u9002\u7528\u4e8e\u6b64\u524d\u63a5\u53d7\u8fc7\u514b\u5511\u66ff\u5c3c\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u6216\u8005\u5bf9\u514b\u5511\u66ff\u5c3c\u4e0d\u8010\u53d7\u7684\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684ALK\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684ALK\u9633\u6027\u3002<\/span><\/p>\n

2. \u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5f71\u50cf\u5b66\u663e\u793a\u7f13\u6162\u8fdb\u5c55\u4f46\u4e34\u5e8a\u75c7\u72b6\u672a\u53d1\u751f\u6076\u5316\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\uff1b\u53d1\u751f\u5c40\u90e8\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\u52a0\u5c40\u90e8\u6cbb\u7597\uff1b\u5bf9\u4e8e\u5feb\u901f\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u6539\u6362\u4e3a\u5176\u4ed6\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n

3.\u672c\u54c1\u7684\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u65e5\u4e00\u6b21\uff0c\u6bcf\u6b21450mg\uff0c\u6bcf\u5929\u5728\u540c\u4e00\u65f6\u95f4\u53e3\u670d\u7ed9\u836f\uff0c\u836f\u7269\u5e94\u4e0e\u98df\u7269\u540c\u65f6\u670d\u7528\u3002<\/span><\/p>\n

4.\u5982\u679c\u5fd8\u8bb0\u670d\u836f\uff0c\u4e14\u8ddd\u4e0b\u6b21\u670d\u836f\u65f6\u95f4\u95f4\u969412\u5c0f\u65f6\u4ee5\u4e0a\u65f6\uff0c\u60a3\u8005\u5e94\u8865\u670d\u6f0f\u670d\u7684\u5242\u91cf\u3002\u82e5\u6cbb\u7597\u671f\u95f4\u53d1\u751f\u5455\u5410\uff0c\u60a3\u8005\u4e0d\u5e94\u670d\u7528\u989d\u5916\u5242\u91cf\uff0c\u4f46\u5e94\u7ee7\u7eed\u670d\u7528\u4e0b\u6b21\u8ba1\u5212\u5242\u91cf\u3002<\/span><\/p>\n

5.\u7528\u836f\u671f\u95f4\u987b\u6ce8\u610f\u80c3\u80a0\u9053\u4e0d\u826f\u53cd\u5e94\u3001\u809d\u6bd2\u6027\u3001\u95f4\u8d28\u6027\u80ba\u708e\/\u975e\u611f\u67d3\u6027\u80ba\u708e\u3001\u5fc3\u5f8b\u5931\u5e38\u3001\u9ad8\u8840\u7cd6\u7b49\u4e0d\u826f\u53cd\u5e94\u3002<\/span><\/p>\n

6.\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u5e94\u907f\u514d\u8054\u5408\u4f7f\u7528\u5f3a\u6548CYP3A\u6291\u5236\u5242\u3002\u5982\u679c\u5fc5\u987b\u540c\u65f6\u4f7f\u7528\u5f3a\u6548CYP3A\u6291\u5236\u5242\uff0c\u5219\u5e94\u5c06\u585e\u745e\u66ff\u5c3c\u7684\u5242\u91cf\u51cf\u5c11\u7ea6\u4e09\u5206\u4e4b\u4e00\uff0c\u53d6\u6574\u81f3\u6700\u63a5\u8fd1\u7684150mg\u6574\u6570\u500d\u5242\u91cf\u3002<\/span><\/p>\n

7.\u5982\u679c\u672c\u54c1\u4e0e\u6291\u5236P-gp\u7684\u836f\u7269\u8054\u5408\u4f7f\u7528\uff0c\u53ef\u80fd\u5bfc\u81f4\u672c\u54c1\u6d53\u5ea6\u5347\u9ad8\u3002\u8054\u5408\u4f7f\u7528P-gp\u6291\u5236\u5242\u65f6\u5e94\u8c28\u614e\uff0c\u6ce8\u610f\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\u3002<\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>8.\u57fa\u4e8eASCEND-4\u7814\u7a76\uff0cALK\u9633\u6027\u7684NSCLC\u53ef\u9009\u62e9\u585e\u745e\u66ff\u5c3c\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>9.\u57fa\u4e8e\u4e00\u9879\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u5728\u7ecf\u5316\u7597\u6cbb\u7597\u540e\u7684ROS1\u91cd\u6392\u7684NSCLC\u60a3\u8005\u53ef\u9009\u62e9\u585e\u745e\u66ff\u5c3c\u8fdb\u884c\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

\u5341\u4e00\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/span><\/strong><\/p>\n

\u901a\u7528\u540d<\/span><\/strong>\uff1a<\/span><\/strong>\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/strong>\uff1a\u9488\u5242\uff1a40mg\uff084ml\uff09\/\u74f6\uff0c100mg\uff0810ml\uff09\/\u74f6<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1<\/span><\/strong>\uff1a\u672c\u54c1\u5355\u836f\u9002\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u65b9\u6848\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\u7684\u4e8c\u7ebf\u6cbb\u7597\uff0c\u9700\u6392\u9664EGFR\u57fa\u56e0\u7a81\u53d8\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u878d\u5408\u7684\u60a3\u8005\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\uff0c\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u65b9\u6848\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u3002<\/span><\/p>\n

2.\u60a3\u8005\u5fc5\u987b\u4e3aEGFR\u9634\u6027\u548cALK\u9634\u6027\u3002<\/span><\/p>\n

3.\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\u3002\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\uff08\u4f8b\u5982\u6700\u521d\u51e0\u4e2a\u6708\u5185\u80bf\u7624\u6682\u65f6\u589e\u5927\u6216\u51fa\u73b0\u65b0\u7684\u5c0f\u75c5\u7076\uff0c\u968f\u540e\u80bf\u7624\u7f29\u5c0f\uff09\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<\/span><\/p>\n

4.\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5728\u4e2d\u56fd\u57fa\u4e8eCheckMate 078\u7814\u7a76\uff0c\u83b7\u6279\u7684\u5242\u91cf\u662f3mg\/kg\uff0c\u6bcf2\u5468\u4e00\u6b21\uff0c60\u5206\u949f\u8f93\u6ce8\u3002\u5728\u6b27\u7f8e\uff0c\u57fa\u4e8ePPK\u7814\u7a76\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5df2\u7ecf\u83b7\u6279\u56fa\u5b9a\u5242\u91cf\uff0c480mg\uff0c\u6bcf4\u5468\u4e00\u6b21\u6216\u8005240mg\uff0c\u6bcf2\u5468\u4e00\u6b21\uff0c30\u5206\u949f\u8f93\u6ce8\u3002<\/span><\/p>\n

5.\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<\/span><\/p>\n

6.\u53d1\u751f4\u7ea7\u6216\u590d\u53d1\u60273\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u57282\u7ea7\u62163\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u3002<\/span><\/p>\n

7.\u8001\u5e74\u60a3\u8005\uff08\u226565\u5c81\uff09\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<\/span><\/p>\n

8.\u8f7b\u6216\u4e2d\u5ea6\u80be\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u91cd\u5ea6\u80be\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002<\/span><\/p>\n

9.\u8f7b\u6216\u4e2d\u5ea6\u809d\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u6ca1\u6709\u5bf9\u91cd\u5ea6\u809d\u635f\u4f24\u60a3\u8005\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\uff0c\u91cd\u5ea6\uff08\u603b\u80c6\u7ea2\u7d20\uff1e3\u500dULN\u548c\u4efb\u4f55AST\uff09\u809d\u635f\u4f24\u60a3\u8005\u5fc5\u987b\u614e\u7528\u672c\u54c1\u3002<\/span><\/p>\n

10.\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u53ef\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u671f\u95f4\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\uff08\u81f3\u5c11\u81f3\u672b\u6b21\u7ed9\u836f\u540e5\u4e2a\u6708\uff09\u3002<\/span><\/p>\n

11.\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u505c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u5e76\u7ed9\u4e88\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3002\u82e5\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u514d\u75ab\u6291\u5236\u7597\u6cd5\u6cbb\u7597\u4e0d\u826f\u53cd\u5e94\uff0c\u75c7\u72b6\u6539\u5584\u540e\uff0c\u9700\u81f3\u5c111\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6e10\u51cf\u91cf\u81f3\u505c\u836f\u3002\u5feb\u901f\u51cf\u91cf\u53ef\u80fd\u5f15\u8d77\u4e0d\u826f\u53cd\u5e94\u6076\u5316\u6216\u590d\u53d1\u3002\u5982\u679c\u867d\u4f7f\u7528\u4e86\u7cd6\u76ae\u8d28\u6fc0\u7d20\u4f46\u4ecd\u6076\u5316\u6216\u65e0\u6539\u5584\uff0c\u5219\u5e94\u589e\u52a0\u975e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6027\u514d\u75ab\u6291\u5236\u6cbb\u7597\u3002<\/span><\/p>\n

12.\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<\/span><\/p>\n

13.\u5982\u679c\u51fa\u73b0\u4efb\u4f55\u91cd\u5ea6\u3001\u590d\u53d1\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55\u5371\u53ca\u751f\u547d\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5fc5\u987b\u6c38\u4e45\u505c\u6b62\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<\/span><\/p>\n

14.\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u662f\u4e00\u79cd\u4eba\u5355\u514b\u9686\u6297\u4f53\uff0c\u56e0\u5355\u514b\u9686\u6297\u4f53\u4e0d\u7ecf\u7ec6\u80de\u8272\u7d20P450\uff08CYP\uff09\u9176\u6216\u5176\u4ed6\u836f\u7269\u4ee3\u8c22\u9176\u4ee3\u8c22\uff0c\u56e0\u6b64\uff0c\u5408\u5e76\u4f7f\u7528\u7684\u836f\u7269\u5bf9\u8fd9\u4e9b\u9176\u7684\u6291\u5236\u6216\u8bf1\u5bfc\u4f5c\u7528\u9884\u671f\u4e0d\u4f1a\u5f71\u54cd\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u3002<\/span><\/p>\n

15.\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\u6bcf\u6beb\u5347\u542b0.1mmol\uff08\u62162.5mg\uff09\u94a0\uff0c\u5728\u5bf9\u63a7\u5236\u94a0\u6444\u5165\u7684\u60a3\u8005\u8fdb\u884c\u6cbb\u7597\u65f6\u5e94\u8003\u8651\u8fd9\u4e00\u56e0\u7d20\u3002<\/span><\/p>\n


<\/p>\n

\u6d88\u5316\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u4e00\u3001\u745e\u6208\u975e\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u745e\u6208\u975e\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a40mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u65e2\u5f80\u63a5\u53d7\u8fc7\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u60a3\u8005\u3002<\/span><\/p>\n

2.\u65e2\u5f80\u63a5\u53d7\u8fc7\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u53ca\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\u7684\u3001\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u6216\u8f6c\u79fb\u6027\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u60a3\u8005\u3002<\/span><\/p>\n

3.\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u6297VEGF\u6cbb\u7597\u3001\u6297EGFR\u6cbb\u7597\uff08RAS\u91ce\u751f\u578b\uff09\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u3002<\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u524d\u65e0\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u3002<\/span><\/p>\n

2.\u836f\u54c1\u8bf4\u660e\u4e66\u63a8\u8350\u5242\u91cf\u4e3a160mg\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u7528\u836f3\u5468\u505c\u836f1\u5468\u3002\u57fa\u4e8e\u4e2a\u4eba\u7684\u5b89\u5168\u53ca\u8010\u53d7\u6027\u8003\u8651\uff0c\u53ef\u80fd\u9700\u8981\u4e2d\u65ad\u6216\u964d\u4f4e\u5242\u91cf\uff0c\u4e5f\u53ef\u4ee5\u8003\u8651\u91c7\u752880\uff5e120mg\u8d77\u59cb\u5242\u91cf\u9010\u6e10\u9012\u589e\u3002<\/span><\/p>\n

3.\u4e9a\u6d32\u4eba\u7fa4\u6700\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u809d\u529f\u80fd\u5f02\u5e38\uff08\u9ad8\u80c6\u7ea2\u7d20\u8840\u75c7\u3001ALT\u5347\u9ad8\u3001AST\u5347\u9ad8\uff09\u548c\u9ad8\u8840\u538b,\u540c\u65f6,\u8fd8\u8981\u6ce8\u610f\u75bc\u75db\u3001\u4e4f\u529b\u3001\u8179\u6cfb\u3001\u98df\u6b32\u4e0b\u964d\u53ca\u8fdb\u98df\u51cf\u5c11\u7b49\u4e0d\u826f\u53cd\u5e94\uff1b\u6700\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u91cd\u5ea6\u809d\u635f\u4f24\u3001\u51fa\u8840\u53ca\u80c3\u80a0\u9053\u7a7f\u5b54\u53ca\u611f\u67d3\uff1b\u6709\u8840\u6813\u3001\u6813\u585e\u75c5\u53f2\u8005\u5e94\u5ba1\u614e\u4f7f\u7528\u3002<\/span><\/p>\n

4.\u5bf9\u745e\u6208\u975e\u5c3c\u4efb\u4e00\u6d3b\u6027\u7269\u8d28\u6216\u8f85\u6599\u6709\u8d85\u654f\u53cd\u5e94\u7684\u60a3\u8005\u7981\u7528\u3002<\/span><\/p>\n

5.\u4e0eCYP3A4\u6d3b\u6027\u7684\u5f3a\u6291\u5236\u5242\uff08\u5982\u514b\u62c9\u9709\u7d20\u3001\u8461\u8404\u67da\u6c41\u3001\u4f0a\u66f2\u5eb7\u5511\u3001\u916e\u5eb7\u5511\u3001\u6cca\u6c99\u5eb7\u5511\u3001\u6cf0\u5229\u9709\u7d20\u548c\u4f0f\u7acb\u5eb7\u5511\uff09\uff0c\u5f3aUGT1A9\u6291\u5236\u5242\uff08\u5982\u7532\u706d\u9178\u3001\u4e8c\u6c1f\u5c3c\u67f3\u548c\u5c3c\u6c1f\u9178\uff09\uff0c\u5f3aCYP3A4\u8bf1\u5bfc\u5242\uff08\u5229\u798f\u5e73\u3001\u82ef\u59a5\u82f1\u3001\u5361\u9a6c\u897f\u5e73\u3001\u82ef\u5df4\u6bd4\u59a5\u548c\u8d2f\u53f6\u8fde\u7fd8\uff09\uff0c\u9700\u5c3d\u91cf\u907f\u514d\u540c\u65f6\u4f7f\u7528\u3002<\/span><\/p>\n

\u4e8c\u3001\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d<\/span><\/strong>\uff1a<\/span><\/strong>\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a0.2g<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u6cbb\u7597\u65e0\u6cd5\u624b\u672f\u6216\u8fdc\u5904\u8f6c\u79fb\u7684\u809d\u7ec6\u80de\u764c\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u671f\u95f4\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u6709\u8179\u6cfb\u3001\u4e4f\u529b\u3001\u8131\u53d1\u3001\u611f\u67d3\u3001\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u76ae\u75b9\u3002<\/span><\/p>\n

2.\u63a8\u8350\u670d\u7528\u5242\u91cf\u4e3a\u6bcf\u6b210.4g\u3001\u6bcf\u65e5\u4e24\u6b21\uff0c\u7a7a\u8179\u6216\u4f34\u4f4e\u8102\u3001\u4e2d\u8102\u996e\u98df\u670d\u7528\uff0c\u5bf9\u7591\u4f3c\u4e0d\u826f\u53cd\u5e94\u7684\u5904\u7406\u5305\u62ec\u6682\u505c\u6216\u51cf\u5c11\u7528\u91cf\uff0c\u5982\u9700\u51cf\u5c11\u5242\u91cf\uff0c\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u7684\u5242\u91cf\u51cf\u4e3a\u6bcf\u65e5\u4e00\u6b21\uff0c\u6bcf\u6b210.4g\uff0c\u53e3\u670d\u3002<\/span><\/p>\n

3.\u4e0e\u901a\u8fc7UGT1A1\u9014\u5f84\u4ee3\u8c22\/\u6e05\u9664\u7684\u836f\u7269\uff08\u5982\u4f0a\u7acb\u66ff\u5eb7\uff09\u3001\u591a\u897f\u4ed6\u8d5b\u8054\u5408\u5e94\u7528\u65f6\u9700\u8c28\u614e\u3002\u4e0e\u534e\u6cd5\u6797\u5408\u7528\u65f6\u5e94\u5b9a\u671f\u68c0\u6d4bINR\u503c\u3002<\/span><\/p>\n

4.\u76ee\u524d\u7f3a\u4e4f\u5728\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\u4e2d\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u4e0e\u4ecb\u5165\u6cbb\u7597\u5982\u809d\u52a8\u8109\u6813\u585e\u5316\u7597\uff08TACE\uff09\u6bd4\u8f83\u7684\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u56e0\u6b64\u5c1a\u4e0d\u80fd\u660e\u786e\u672c\u54c1\u76f8\u5bf9\u4ecb\u5165\u6cbb\u7597\u7684\u4f18\u52a3\uff0c\u4e5f\u4e0d\u80fd\u660e\u786e\u5bf9\u65e2\u5f80\u63a5\u53d7\u8fc7\u4ecb\u5165\u6cbb\u7597\u540e\u60a3\u8005\u4f7f\u7528\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u662f\u5426\u6709\u76ca\u3002<\/span><\/p>\n

5. TACTICS\u7814\u7a76\uff08NCT01217034\uff09\u8bc1\u5b9e\u9996\u6b21TACE\u8054\u5408\u7d22\u62c9\u975e\u5c3c\u8f83\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u7ec4\u83b7\u76ca\u66f4\u4f73\u3002<\/span><\/p>\n

\u4e09\u3001\u66f2\u59a5\u73e0\u5355\u6297<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u6ce8\u5c04\u7528\u66f2\u59a5\u73e0\u5355\u6297<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u9488\u5242\uff1a440mg\uff0820ml\uff09\/\u74f6<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u672c\u54c1\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u62165-\u6c1f\u5c3f\u5627\u5576\u548c\u987a\u94c2\u9002\u7528\u4e8e\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u9488\u5bf9\u8f6c\u79fb\u6027\u75be\u75c5\u6cbb\u7597\u7684HER2\u9633\u6027\u7684\u8f6c\u79fb\u6027\u80c3\u817a\u764c\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u817a\u764c\u60a3\u8005\uff0c\u5bf9\u4e8e\u987a\u94c2\u548c\u6c1f\u5c3f\u5bc6\u5576\u7c7b\u8fdb\u5c55\uff0c\u800c\u672a\u4f7f\u7528\u8fc7\u66f2\u59a5\u73e0\u5355\u6297\u7684HER2\u9633\u6027\u7684\u8f6c\u79fb\u6027\u80c3\u764c\u60a3\u8005\uff0c\u53ef\u4ee5\u8003\u8651\u66f2\u59a5\u73e0\u5355\u6297\u8054\u5408\u5176\u4ed6\u6709\u6548\u7684\u5316\u7597\u836f\u7269\u6cbb\u7597\uff1b\u66f2\u59a5\u73e0\u5355\u6297\u53ea\u80fd\u7528\u4e8eHER2\u9633\u6027\u7684\u8f6c\u79fb\u6027\u80c3\u764c\u60a3\u8005\uff0cHER2\u9633\u6027\u7684\u5b9a\u4e49\u4e3a\u4f7f\u7528\u5df2\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u5f97\u5230\u7684IHC3+\u6216IHC2+\/FISH+\u7ed3\u679c\u3002    <\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u5728\u672c\u54c1\u6cbb\u7597\u524d\uff0c\u5e94\u8fdb\u884cHER2\u68c0\u6d4b\uff0c\u76f8\u5173\u68c0\u6d4b\u5e94\u4f7f\u7528\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u3002<\/span><\/p>\n

2.\u66f2\u59a5\u73e0\u5355\u6297\u5f00\u59cb\u6cbb\u7597\u524d\u5e94\u8fdb\u884c\u5de6\u5ba4\u5c04\u8840\u5206\u6570\uff08LVEF\uff09\u7684\u68c0\u6d4b\uff0c\u6cbb\u7597\u671f\u95f4\u987b\u7ecf\u5e38\u5bc6\u5207\u76d1\u6d4bLVEF\u3002<\/span><\/p>\n

3.\u80c3\u764c\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u60a3\u8005\u51fa\u73b0\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u3001\u5de6\u5fc3\u5ba4\u529f\u80fd\u660e\u663e\u4e0b\u964d\u3001\u4e25\u91cd\u7684\u8f93\u6ce8\u53cd\u5e94\u548c\u80ba\u90e8\u53cd\u5e94\u65f6\uff0c\u8981\u4e2d\u65ad\u6216\u505c\u6b62\u66f2\u59a5\u73e0\u5355\u6297\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

\u56db\u3001\u7532\u78fa\u9178\u963f\u5e15\u66ff\u5c3c<\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u7532\u78fa\u9178\u963f\u5e15\u66ff\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a0.25g\u30010.375g\u30010.425g<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc72\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u8fdb\u5c55\u6216\u590d\u53d1\u7684\u665a\u671f\u80c3\u817a\u764c\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u60a3\u8005\uff0c\u4e14\u60a3\u8005\u63a5\u53d7\u7532\u78fa\u9178\u963f\u5e15\u66ff\u5c3c\u6cbb\u7597\u65f6\u4e00\u822c\u72b6\u51b5\u826f\u597d\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u836f\u54c1\u8bf4\u660e\u4e66\u63a8\u8350\u5242\u91cf\u4e3a850mg\uff0c\u6bcf\u65e5\u4e00\u6b21\u3002\u5bf9\u4e8e\u4f53\u529b\u72b6\u6001\u8bc4\u5206ECOG\u22652\u3001\u56db\u7ebf\u5316\u7597\u4ee5\u540e\u3001\u80c3\u90e8\u539f\u53d1\u764c\u7076\u6ca1\u6709\u5207\u9664\u3001\u9aa8\u9ad3\u529f\u80fd\u50a8\u5907\u5dee\u3001\u5e74\u8001\u4f53\u5f31\u6216\u7626\u5c0f\u7684\u5973\u6027\u60a3\u8005\uff0c\u4e3a\u4e86\u786e\u4fdd\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u63d0\u9ad8\u4f9d\u4ece\u6027\uff0c\u53ef\u4ee5\u9002\u5f53\u964d\u4f4e\u8d77\u59cb\u5242\u91cf\uff0c\u5148\u4ece500mg\u5f00\u59cb\u670d\u836f\uff0c\u670d\u75281\uff5e2\u5468\u540e\u518d\u914c\u60c5\u589e\u52a0\u5242\u91cf\u3002<\/span><\/p>\n

2.\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u51fa\u73b03\uff5e4\u7ea7\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u5efa\u8bae\u6682\u505c\u7528\u836f\uff0c\u5e76\u5bf9\u75c7\u5904\u7406\uff0c\u5f85\u75c7\u72b6\u7f13\u89e3\u6062\u590d\u52301\u7ea7\u4ee5\u5185\uff0c\u968f\u540e\u964d\u4f4e\u5242\u91cf\u670d\u7528\u3002<\/span><\/p>\n

3.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u7279\u522b\u5173\u6ce8\u8840\u538b\u5347\u9ad8\u3001\u86cb\u767d\u5c3f\u3001\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u51fa\u8840\u3001\u5fc3\u810f\u6bd2\u6027\u3001\u809d\u810f\u6bd2\u6027\u7b49\u4e0d\u826f\u53cd\u5e94\u3002<\/span><\/p>\n

4.\u614e\u4e0eCYP3A4\u4ee3\u8c22\u836f\u7269\u3001CYP2C9\u4ee3\u8c22\u836f\u7269\u3001\u5ef6\u957fQT\u95f4\u671f\u7684\u836f\u7269\u540c\u65f6\u4f7f\u7528\u3002<\/span><\/p>\n

\u4e94\u3001\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c\u80f6\u56ca<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u80f6\u56ca\uff1a12.5mg\u300125mg\u300137.5mg\u300150mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u5931\u8d25\u6216\u4e0d\u80fd\u8010\u53d7\u7684\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u60a3\u8005\u3002<\/span><\/p>\n

2.\u4e0d\u53ef\u5207\u9664\u7684\u3001\u8f6c\u79fb\u6027\u9ad8\u5206\u5316\u8fdb\u5c55\u671f\u80f0\u817a\u795e\u7ecf\u5185\u5206\u6ccc\u7624\uff08pNET\uff09\u6210\u5e74\u60a3\u8005\u3002<\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.<\/span><\/strong>\u6bcf\u65e5\u63a8\u8350\u6700\u9ad8\u5242\u91cf50mg\uff0c\u670d\u836f4\u5468\u3001\u505c\u836f2\u5468\uff0c\u4e0e\u8fdb\u98df\u65e0\u76f8\u5173\u6027\uff1b\u82e5\u5fc5\u987b\u4e0eCYP3A4\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\uff0c\u5242\u91cf\u53ef\u51cf\u81f337.5mg\uff1b\u82e5\u5fc5\u987b\u4e0eCYP3A4\u8bf1\u5bfc\u5242\u8054\u5408\u4f7f\u7528\uff0c\u6700\u5927\u5242\u91cf\u4e0d\u8d85\u8fc787.5mg\u3002<\/span><\/span><\/p>\n

2.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u4f8b\u5982\uff1a\u767d\u7ec6\u80de\u51cf\u5c11\u3001\u8179\u6cfb\u3001\u4e4f\u529b\u3001\u624b\u8db3\u7efc\u5408\u5f81\uff1b\u6f5c\u5728\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u809d\u6bd2\u6027\u3001\u5de6\u5fc3\u5ba4\u529f\u80fd\u969c\u788d\u3001QT\u95f4\u671f\u5ef6\u957f\u3001\u51fa\u8840\u3001\u9ad8\u8840\u538b\u3001\u7532\u72b6\u817a\u529f\u80fd\u4e0d\u5168\u3002<\/span><\/p>\n

3.\u82e5\u51fa\u73b0\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u7684\u4e34\u5e8a\u8868\u73b0\uff0c\u5efa\u8bae\u505c\u836f\uff1b\u65e0\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u4e34\u5e8a\u8bc1\u636e\u4f46\u5c04\u8840\u5206\u6570\uff1c50%\u4ee5\u53ca\u5c04\u8840\u5206\u6570\u4f4e\u4e8e\u57fa\u7ebf20%\u7684\u60a3\u8005\u4e5f\u5e94\u505c\u836f\u548c\/\u6216\u51cf\u91cf\u3002<\/span><\/p>\n

4.\u53ef\u5ef6\u957fQT\u95f4\u671f\uff0c\u4e14\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u5e94\u614e\u7528\u4e8e\u5df2\u77e5\u6709QT\u95f4\u671f\u5ef6\u957f\u75c5\u53f2\u7684\u60a3\u8005\u3001\u670d\u7528\u6297\u5fc3\u5f8b\u5931\u5e38\u836f\u7269\u7684\u60a3\u8005\u6216\u6709\u76f8\u5e94\u57fa\u7840\u5fc3\u810f\u75be\u75c5\u3001\u5fc3\u52a8\u8fc7\u7f13\u548c\u7535\u89e3\u8d28\u7d0a\u4e71\u7684\u60a3\u8005\u3002<\/span><\/p>\n

5.\u4f7f\u7528\u671f\u95f4\u5982\u679c\u53d1\u751f\u4e25\u91cd\u9ad8\u8840\u538b\uff0c\u5e94\u6682\u505c\u4f7f\u7528\uff0c\u76f4\u81f3\u9ad8\u8840\u538b\u5f97\u5230\u63a7\u5236\u3002<\/span><\/p>\n

6.\u907f\u514d\u540c\u65f6\u4f7f\u7528CYP3A4\u6291\u5236\u5242\u3001\u8bf1\u5bfc\u5242\u3002<\/span><\/p>\n

\u516d\u3001\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a0.1g<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u4e8e\u6cbb\u7597\u4e0d\u80fd\u5207\u9664\u548c\/\u6216\u53d1\u751f\u8f6c\u79fb\u7684\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u6210\u4eba\u60a3\u8005\u3002<\/span><\/p>\n

2.\u7528\u4e8eKit\uff08CD117\uff09\u9633\u6027\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u624b\u672f\u5207\u9664\u540e\u5177\u6709\u660e\u663e\u590d\u53d1\u98ce\u9669\u7684\u6210\u4eba\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\u3002<\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u4f8b\u5982\uff1a\u4f53\u6db2\u6f74\u7559\u3001\u6076\u5fc3\u3001\u8179\u6cfb\u3001\u76ae\u75b9\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u3001\u75bc\u75db\u6027\u808c\u75c9\u631b\u3001\u4ee5\u53ca\u809d\u529f\u80fd\u635f\u4f24\u3002<\/span><\/p>\n

2.\u809d\u529f\u80fd\u635f\u5bb3\u8005\u614e\u7528\u672c\u836f\u7269\uff0c\u907f\u514d\u540c\u65f6\u4f7f\u7528CYP3A4\u6291\u5236\u5242\u3001\u8bf1\u5bfc\u5242\uff0c\u5c24\u5176\u9700\u8981\u8b66\u60d5\u4e0e\u5bf9\u4e59\u9170\u6c28\u57fa\u915a\u7c7b\u836f\u7269\u8054\u5408\u4f7f\u7528\u3002<\/span><\/p>\n

3.\u6cbb\u7597\u540e\u82e5\u672a\u80fd\u83b7\u5f97\u6ee1\u610f\u7597\u6548\uff0c\u5982\u679c\u6ca1\u6709\u4e25\u91cd\u836f\u7269\u4e0d\u826f\u53cd\u5e94\uff0c\u5242\u91cf\u53ef\u589e\u52a0\u5230\u6bcf\u59290.6\uff5e0.8g\uff1b\u82e5\u60a3\u8005\u4ece\u672c\u836f\u6301\u7eed\u83b7\u76ca\uff0c\u53ef\u6301\u7eed\u63a5\u53d7\u672c\u836f\u6cbb\u7597\u3002<\/span><\/p>\n

4.\u5bf9\u4e8e\u6f5c\u5728\u53ef\u5207\u9664\u7684\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u60a3\u8005\uff0c\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u65b0\u8f85\u52a9\u6cbb\u7597\u4e5f\u53ef\u4ee4\u60a3\u8005\u83b7\u76ca\u3002<\/span><\/p>\n

\u4e03\u3001\u4f9d\u7ef4\u83ab\u53f8<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u4f9d\u7ef4\u83ab\u53f8\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a2.5mg\u30015mg\u300110mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u4e0d\u53ef\u5207\u9664\u7684\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u7684\u3001\u5206\u5316\u826f\u597d\u7684\uff08\u4e2d\u5ea6\u5206\u5316\u6216\u9ad8\u5ea6\u5206\u5316\uff09\u8fdb\u5c55\u671f\u80f0\u817a\u3001\u80c3\u80a0\u9053\u6216\u80ba\u6e90\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u6210\u4eba\u60a3\u8005\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u53e3\u8154\u708e\u3001\u76ae\u75b9\u3001\u75b2\u52b3\u3001\u8179\u6cfb\u3001\u611f\u67d3\u3001\u6076\u5fc3\u3001\u98df\u6b32\u4e0b\u964d\u3001\u8d2b\u8840\u3001\u5473\u89c9\u969c\u788d\u3001\u5468\u56f4\u6c34\u80bf\u3001\u9ad8\u8840\u7cd6\u548c\u5934\u75db\u3002<\/span><\/p>\n

2.\u975e\u611f\u67d3\u6027\u80ba\u708e\u662f\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\uff08\u5305\u62ec\u672c\u54c1\uff09\u7684\u7c7b\u6548\u5e94\u3002\u5bf9\u672c\u54c1\u6709\u6548\u6210\u5206\u3001\u5176\u4ed6\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\u6216\u672c\u54c1\u4e2d\u4efb\u4f55\u8f85\u6599\u8fc7\u654f\u8005\u7981\u7528\u3002\u4f7f\u7528\u4f9d\u7ef4\u83ab\u53f8\u548c\u5176\u4ed6\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u8fc7\u654f\u53cd\u5e94\u8868\u73b0\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff1a\u547c\u5438\u56f0\u96be\u3001\u6f6e\u7ea2\u3001\u80f8\u75db\u6216\u8840\u7ba1\u6027\u6c34\u80bf\uff08\u4f8b\u5982\uff1a\u4f34\u6216\u4e0d\u4f34\u547c\u5438\u529f\u80fd\u4e0d\u5168\u7684\u6c14\u9053\u6216\u820c\u80bf\u80c0\uff09\u3002<\/span><\/p>\n

3.\u540c\u65f6\u4f7f\u7528\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u6362\u9176\u6291\u5236\u5242\u7684\u60a3\u8005\uff0c\u53ef\u80fd\u53d1\u751f\u8840\u7ba1\u6027\u6c34\u80bf\uff08\u5982\u6c14\u9053\u6216\u820c\u80bf\u80c0\uff0c\u4f34\u6709\u6216\u4e0d\u4f34\u6709\u547c\u5438\u9053\u635f\u5bb3\uff09\u7684\u98ce\u9669\u5347\u9ad8\u3002<\/span><\/p>\n

4.\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u5e94\u907f\u514d\u63a5\u79cd\u6d3b\u75ab\u82d7\uff0c\u4f8b\u5982\u6d41\u611f\u3001\u9ebb\u75b9\u3001\u816e\u817a\u708e\u3001\u98ce\u75b9\u3001\u53e3\u670d\u810a\u9ad3\u7070\u8d28\u708e\u3001\u5361\u4ecb\u82d7\u3001\u9ec4\u70ed\u75c5\u3001\u6c34\u75d8\u548cTY21a\u4f24\u5bd2\u75ab\u82d7\u7b49\uff0c\u907f\u514d\u4e0e\u63a5\u79cd\u8fc7\u6d3b\u75ab\u82d7\u7684\u4eba\u5bc6\u5207\u63a5\u89e6\u3002<\/span><\/p>\n

5.\u5e94\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5f3a\u6548CYP3A4\/\u6216P-\u7cd6\u86cb\u767d\u6291\u5236\u5242\u3001CYP3A4\u5f3a\u6548\u8bf1\u5bfc\u5242\u3002<\/span><\/p>\n

\u516b\u3001\u8d1d\u4f10\u73e0\u5355\u6297<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u8d1d\u4f10\u73e0\u5355\u6297\u6ce8\u5c04\u6db2<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u9488\u5242\uff1a100mg\uff084ml\uff09\/\u74f6<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u3002<\/span><\/p>\n

2.\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u4ee55-\u6c1f\u5c3f\u5627\u5576\u4e3a\u57fa\u7840\u7684\u5316\u7597\u9002\u7528\u4e8e\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u4e00\u3001\u4e8c\u7ebf\u6cbb\u7597\uff0c\u53ef\u9009\u62e9\u8d1d\u4f10\u73e0\u5355\u6297+\u5316\u7597\u3002<\/span><\/p>\n

2.\u4e00\u7ebf\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u75c5\u60c5\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u4e8c\u7ebf\u8f6c\u6362\u5316\u7597\u65b9\u6848\u4f46\u53ef\u7ee7\u7eed\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\u3002<\/span><\/p>\n

3.\u4e00\u7ebf\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u75c5\u60c5\u63a7\u5236\u540e\uff0c\u53ef\u9009\u62e9\u8d1d\u4f10\u73e0\u5355\u6297\u00b1\u6c1f\u5c3f\u5627\u5576\u7c7b\u836f\u7269\u7ef4\u6301\u6cbb\u7597\u76f4\u81f3\u75c5\u60c5\u8fdb\u5c55\u3002<\/span><\/p>\n

4.\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u8d1d\u4f10\u73e0\u5355\u6297\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a\uff1a\u8054\u5408FOLFOX\/FOLFIRI\u5316\u7597\u65b9\u6848\u65f6\uff0c5mg\/kg\uff0c\u6bcf\u4e24\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u8054\u5408XELOX\u5316\u7597\u65b9\u6848\u65f6\uff0c7.5mg\/kg\uff0c\u6bcf\u4e09\u5468\u7ed9\u836f\u4e00\u6b21\u3002<\/span><\/p>\n

5.\u8d1d\u4f10\u73e0\u5355\u6297\u7a00\u91ca\u540e\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9996\u6b21\u9759\u8109\u8f93\u6ce8\u65f6\u95f4\u9700\u6301\u7eed90\u5206\u949f\u3002\u5982\u679c\u7b2c\u4e00\u6b21\u8f93\u6ce8\u8010\u53d7\u6027\u826f\u597d\uff0c\u5219\u7b2c\u4e8c\u6b21\u8f93\u6ce8\u7684\u65f6\u95f4\u53ef\u4ee5\u7f29\u77ed\u523060\u5206\u949f\u3002\u5982\u679c\u60a3\u8005\u5bf960\u5206\u949f\u7684\u8f93\u6ce8\u4e5f\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u90a3\u4e48\u968f\u540e\u8fdb\u884c\u7684\u6240\u6709\u8f93\u6ce8\u90fd\u53ef\u4ee5\u752830\u5206\u949f\u7684\u65f6\u95f4\u5b8c\u6210\u3002<\/span><\/p>\n

6.\u5728\u8001\u5e74\u4eba\u4e2d\u5e94\u7528\u65f6\u4e0d\u9700\u8981\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<\/span><\/p>\n

7.\u51fa\u73b0\u4ee5\u4e0b\u60c5\u51b5\uff0c\u505c\u6b62\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\uff1a\u80c3\u80a0\u9053\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff08\u80c3\u80a0\u9053\u7a7f\u5b54\u3001\u80c3\u80a0\u9053\u7618\u5f62\u6210\u3001\u8179\u8154\u8113\u80bf\uff09\uff0c\u6d89\u53ca\u5230\u5185\u810f\u7618\u5f62\u6210\uff1b\u9700\u8981\u5e72\u9884\u6cbb\u7597\u7684\u4f24\u53e3\u88c2\u5f00\u4ee5\u53ca\u4f24\u53e3\u6108\u5408\u5e76\u53d1\u75c7\uff1b\u4e25\u91cd\u51fa\u8840\uff08\u4f8b\u5982\u9700\u8981\u5e72\u9884\u6cbb\u7597\uff09\uff1b\u4e25\u91cd\u52a8\u8109\u8840\u6813\u4e8b\u4ef6\uff1b\u9ad8\u8840\u538b\u5371\u8c61\u6216\u9ad8\u8840\u538b\u8111\u75c5\uff1b\u53ef\u9006\u6027\u540e\u90e8\u767d\u8d28\u8111\u75c5\u7efc\u5408\u5f81\uff08RPLS\uff09\uff1b\u80be\u75c5\u7efc\u5408\u5f81\u3002<\/span><\/p>\n

8.\u5982\u679c\u51fa\u73b0\u4ee5\u4e0b\u72b6\u51b5\uff0c\u9700\u6682\u505c\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\uff1a\u62e9\u671f\u624b\u672f\u524d6\u5468\uff1b\u836f\u7269\u63a7\u5236\u4e0d\u826f\u7684\u4e25\u91cd\u9ad8\u8840\u538b\uff1b\u4e2d\u5ea6\u5230\u91cd\u5ea6\u7684\u86cb\u767d\u5c3f\u9700\u8981\u8fdb\u4e00\u6b65\u8bc4\u4f30\uff1b\u4e25\u91cd\u8f93\u6db2\u53cd\u5e94\u3002<\/span><\/p>\n

9.\u4e0d\u80fd\u5c06\u8d1d\u4f10\u73e0\u5355\u6297\u8f93\u6ce8\u6db2\u4e0e\u53f3\u65cb\u7cd6\u6216\u8461\u8404\u7cd6\u6eb6\u6db2\u540c\u65f6\u6216\u6df7\u5408\u7ed9\u836f\u3002<\/span><\/p>\n

10.\u4e0d\u80fd\u91c7\u7528\u9759\u8109\u5185\u63a8\u6ce8\u6216\u5feb\u901f\u6ce8\u5c04\u3002<\/span><\/p>\n

11.\u8d1d\u4f10\u73e0\u5355\u6297\u914d\u5236\uff0c\u75280.9%\u7684\u6c2f\u5316\u94a0\u6eb6\u6db2\u7a00\u91ca\u5230\u9700\u8981\u7684\u7ed9\u836f\u5bb9\u79ef\u3002\u8d1d\u4f10\u73e0\u5355\u6297\u6eb6\u6db2\u7684\u7ec8\u6d53\u5ea6\u5e94\u8be5\u4fdd\u6301\u57281.4\uff5e16.5mg\/ml\u4e4b\u95f4\u3002<\/span><\/p>\n

12.\u8d1d\u4f10\u73e0\u5355\u6297\u7981\u6b62\u51b7\u51bb\u4fdd\u5b58\uff0c\u7981\u6b62\u6447\u52a8\u3002\u5e94\u907f\u5149\uff0c2\uff5e8\u2103\u5728\u539f\u5305\u88c5\u4e2d\u4fdd\u5b58\u548c\u8fd0\u8f93\u3002<\/span><\/p>\n

13.\u57282\uff5e30\u2103\u6761\u4ef6\u4e0b\uff0c0.9%\u7684\u6c2f\u5316\u94a0\u6eb6\u6db2\u4e2d\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\u5728\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u7684\u5316\u5b66\u548c\u7269\u7406\u7a33\u5b9a\u6027\u53ef\u4ee5\u4fdd\u630148\u4e2a\u5c0f\u65f6\u3002\u4ea7\u54c1\u914d\u5236\u540e\u57282\uff5e8\u2103\u6761\u4ef6\u4e0b\u7684\u4fdd\u5b58\u65f6\u95f4\u4e0d\u5b9c\u8d85\u8fc724\u5c0f\u65f6\u3002<\/span><\/p>\n

\u4e5d\u3001\u897f\u59a5\u6614\u5355\u6297<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u897f\u59a5\u6614\u5355\u6297\u6ce8\u5c04\u6db2<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u9488\u5242\uff1a100mg\uff0820ml\uff09\/\u74f6<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u7528\u4e8e\u6cbb\u7597\u8868\u8fbeEGFR\u3001RAS\u57fa\u56e0\u91ce\u751f\u578b\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff0c\u4e0e\u4f0a\u7acb\u66ff\u5eb7\u8054\u5408\u7528\u4e8e\u7ecf\u542b\u4f0a\u7acb\u66ff\u5eb7\u6cbb\u7597\u5931\u8d25\u540e\u7684\u60a3\u8005\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u524d\u5fc5\u987b\u4f7f\u7528\u7ecf\u8fc7\u9a8c\u8bc1\u7684\u65b9\u6cd5\u68c0\u6d4bRAS\u57fa\u56e0\u72b6\u6001\uff0cRAS\u57fa\u56e0\u91ce\u751f\u578b\u662f\u63a5\u53d7\u897f\u59a5\u6614\u5355\u6297\u6cbb\u7597\u7684\u5148\u51b3\u6761\u4ef6\uff0c\u672c\u54c1\u4e0d\u7528\u4e8e\u6cbb\u7597RAS\u57fa\u56e0\u7a81\u53d8\u578b\u6216RAS\u72b6\u6001\u4e0d\u660e\u7684\u60a3\u8005\u3002<\/span><\/p>\n

2.\u8f6c\u5316\u6027\u6cbb\u7597\uff1a\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u5408\u5e76\u809d\u8f6c\u79fb\u548c\/\u6216\u80ba\u8f6c\u79fb\uff0c\u6f5c\u5728\u53ef\u5207\u9664\uff0c\u53ef\u9009\u62e9\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u5316\u7597\uff08RAS\u91ce\u751f\u578b\uff09\u3002<\/span><\/p>\n

3.\u59d1\u606f\u6cbb\u7597\uff1a\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff08RAS\u91ce\u751f\u578b\uff09\u4e00\u3001\u4e8c\u7ebf\u6cbb\u7597\uff0c\u5c24\u5176\u662f\u5de6\u534a\u80a0\u764c\u60a3\u8005\uff0c\u53ef\u9009\u62e9\u897f\u59a5\u6614\u5355\u6297+\u5316\u7597\u3002\u5bf9\u4e00\u3001\u4e8c\u7ebf\u6cbb\u7597\u4e2d\u6ca1\u6709\u4f7f\u7528\u897f\u59a5\u6614\u5355\u6297\u7684\u60a3\u8005\uff08RAS\u91ce\u751f\u578b\uff09\uff0c\u53ef\u9009\u62e9\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u4f0a\u7acb\u66ff\u5eb7\u5316\u7597\u3002<\/span><\/p>\n

4.\u5982\u679c\u521d\u59cb\u4f7f\u7528\u897f\u59a5\u6614\u5355\u6297\u6cbb\u7597\uff0c\u5728\u4e8c\u7ebf\u6216\u8005\u968f\u540e\u7684\u6cbb\u7597\u4e2d\u5747\u4e0d\u5e94\u518d\u4f7f\u7528\u897f\u59a5\u6614\u5355\u6297\u6cbb\u7597\u3002<\/span><\/p>\n

5.\u672c\u54c1\u5e38\u53ef\u5f15\u8d77\u4e0d\u540c\u7a0b\u5ea6\u7684\u76ae\u80a4\u6bd2\u6027\u53cd\u5e94\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u75e4\u75ae\u6837\u76ae\u75b9\uff0c\u6b64\u7c7b\u60a3\u8005\u7528\u836f\u671f\u95f4\u5e94\u6ce8\u610f\u907f\u5149\u3002\u8f7b\u81f3\u4e2d\u5ea6\u76ae\u80a4\u6bd2\u6027\u53cd\u5e94\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u53d1\u751f\u91cd\u5ea6\u76ae\u80a4\u6bd2\u6027\u53cd\u5e94\u8005\uff0c\u5e94\u914c\u60c5\u51cf\u91cf\u3002<\/span><\/p>\n

6.\u4e25\u91cd\u7684\u8f93\u6db2\u53cd\u5e94\u53d1\u751f\u7387\u4e3a3%\uff0c\u81f4\u6b7b\u7387\u4f4e\u4e8e0.1%\u3002\u5176\u4e2d90%\u53d1\u751f\u4e8e\u7b2c\u4e00\u6b21\u4f7f\u7528\u65f6\uff0c\u4ee5\u7a81\u53d1\u6027\u6c14\u9053\u6897\u963b\u3001\u8368\u9ebb\u75b9\u548c\u4f4e\u8840\u538b\u4e3a\u7279\u5f81\u3002\u9996\u6b21\u6ef4\u6ce8\u672c\u54c1\u4e4b\u524d\uff0c\u60a3\u8005\u5fc5\u987b\u63a5\u53d7\u6297\u7ec4\u80fa\u836f\u7269\u548c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7c7b\u836f\u7269\u7684\u6cbb\u7597\uff0c\u5efa\u8bae\u5728\u968f\u540e\u6bcf\u6b21\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u90fd\u5bf9\u60a3\u8005\u8fdb\u884c\u8fd9\u79cd\u6cbb\u7597\u3002<\/span><\/p>\n

7.\u4ec5\u5bf9\u809d\u80be\u529f\u80fd\u6b63\u5e38\u7684\u60a3\u8005\uff08\u8840\u6e05\u808c\u9150\u2264\u6b63\u5e38\u503c\u4e0a\u9650\u76841.5\u500d\uff0c\u8f6c\u6c28\u9176\u2264\u6b63\u5e38\u503c\u4e0a\u9650\u76845\u500d\uff0c\u80c6\u7ea2\u7d20\u2264\u6b63\u5e38\u503c\u4e0a\u9650\u76841.5\u500d\uff09\u8fdb\u884c\u8fc7\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<\/span><\/p>\n

8.\u672c\u54c1\u5e94\u8d2e\u85cf\u5728\u51b0\u7bb1\u4e2d\uff082\uff5e8\u2103\uff09\uff0c\u7981\u6b62\u51b7\u51bb\uff0c\u5f00\u542f\u540e\u5e94\u7acb\u5373\u4f7f\u7528\u3002<\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>9.\u4e0eFOLFOX\u8054\u5408\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597RAS\u57fa\u56e0\u91ce\u751f\u578b\u3001\u8868\u8fbeEGFR\u57fa\u56e0\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08\u5df2\u6709\u2162\u671f\u4e34\u5e8a\u7ed3\u679c\uff0c\u6b63\u5728\u7533\u62a5\u4e2d\u56fd\u9002\u5e94\u8bc1\uff09\u3002<\/span><\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>10.\u4e0eFOLFIRI\u8054\u5408\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597RAS\u57fa\u56e0\u91ce\u751f\u578b\u3001\u8868\u8fbeEGFR\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08\u7f8e\u56fdFDA\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<\/span><\/span><\/p>\n


<\/p>\n

\u8840\u6db2\u80bf\u7624\u7528\u836f<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u4e00\u3001\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u7247\uff0c\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u80f6\u56ca<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\uff081\uff09\u7247\u5242\uff1a100mg\u3001400mg\uff1b\uff082\uff09\u80f6\u56ca\uff1a50mg\u3001100mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u7528\u4e8e\u6cbb\u7597\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff08Ph+CML\uff09\u7684\u6162\u6027\u671f\u3001\u52a0\u901f\u671f\u6216\u6025\u53d8\u671f\uff1b\u8054\u5408\u5316\u7597\u6cbb\u7597\u65b0\u8bca\u65ad\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08Ph+ALL\uff09\u7684\u513f\u7ae5\u60a3\u8005\uff1b\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u7684\u6216\u96be\u6cbb\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08Ph+ALL\uff09\u7684\u6210\u4eba\u60a3\u8005\uff1b\u7528\u4e8e\u6cbb\u7597\u55dc\u9178\u7c92\u7ec6\u80de\u589e\u591a\u7efc\u5408\u5f81\uff08HES\uff09\u548c\/\u6216\u6162\u6027\u55dc\u9178\u7c92\u7ec6\u80de\u767d\u8840\u75c5\uff08CEL\uff09\u4f34\u6709FIP1L1-PDGFR\u03b1\u878d\u5408\u57fa\u56e0\u7684\u6210\u5e74\u60a3\u8005\uff1b\u7528\u4e8e\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\/\u9aa8\u9ad3\u589e\u6b96\u6027\u75be\u75c5\uff08MDS\/MPD\uff09\u4f34\u6709\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08PDGFR\uff09\u57fa\u56e0\u91cd\u6392\u7684\u6210\u5e74\u60a3\u8005\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6216BCR-ABL\u9633\u6027\u7684\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\u6216\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff0c\u6216\u4f34\u6709PDGFR\u57fa\u56e0\u91cd\u6392\u7684\u9ad3\u7cfb\u589e\u6b96\u6027\u80bf\u7624\u3002<\/span><\/p>\n

2.\u5e94\u5f53\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u8840\u6db2\u5b66\u3001\u7ec6\u80de\u9057\u4f20\u5b66\u548c\u5206\u5b50\u751f\u7269\u5b66\u53cd\u5e94\u3002<\/span><\/p>\n

3.\u6839\u636e\u4e0d\u540c\u75be\u75c5\u79cd\u7c7b\u548c\u5206\u671f\uff0c\u9009\u62e9\u521d\u59cb\u6cbb\u7597\u5242\u91cf\uff0c\u6cbb\u7597\u4e2d\u6839\u636e\u7597\u6548\u548c\u4e0d\u826f\u53cd\u5e94\u8c03\u6574\u5242\u91cf\u3002<\/span><\/p>\n

4.\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\uff08\uff1e10%\uff09\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0c\u8840\u5c0f\u677f\u51cf\u5c11\uff0c\u8d2b\u8840\uff0c\u5934\u75db\uff0c\u6d88\u5316\u4e0d\u826f\uff0c\u6c34\u80bf\uff0c\u4f53\u91cd\u589e\u52a0\uff0c\u6076\u5fc3\uff0c\u5455\u5410\uff0c\u808c\u8089\u75c9\u631b\uff0c\u808c\u8089\u9aa8\u9abc\u75db\uff0c\u8179\u6cfb\uff0c\u76ae\u75b9\uff0c\u75b2\u52b3\u548c\u8179\u75db\u3002<\/span><\/p>\n

5.\u6cbb\u7597\u671f\u95f4\u56e0\u6bd2\u6027\u4e0d\u53ef\u8010\u53d7\u6216\u8010\u836f\u65f6\uff0c\u53ef\u9009\u62e9\u4e8c\u4ee3\u836f\u7269\u66ff\u6362\u3002<\/span><\/p>\n

6.CYP3A4\u6291\u5236\u5242\u548c\u8bf1\u5bfc\u5242\u4f1a\u5f71\u54cd\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u66b4\u9732\u5242\u91cf\uff0c\u5408\u5e76\u7528\u836f\u9700\u8c28\u614e\u3002<\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>7.\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u7528\u4e8e\u521d\u6cbbPh+\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08\u5168\u7403\u5176\u4ed6\u56fd\u5bb6\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<\/span><\/span><\/p>\n

\u4e8c\u3001\u8fbe\u6c99\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u8fbe\u6c99\u66ff\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a20mg\u300150mg\u300170mg\u3001100mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u5bf9\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u8010\u836f\uff0c\u6216\u4e0d\u8010\u53d7\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\u3001\u52a0\u901f\u671f\u548c\u6025\u53d8\u671f\uff08\u6025\u7c92\u53d8\u548c\u6025\u6dcb\u53d8\uff09\u6210\u5e74\u60a3\u8005\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6216BCR-ABL\u9633\u6027\u7684\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\u6216\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3002<\/span><\/p>\n

2.\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\uff08\u5305\u62ecBCR-ABL\u7a81\u53d8\uff09\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u8840\u6db2\u5b66\u3001\u7ec6\u80de\u9057\u4f20\u5b66\u548c\u5206\u5b50\u5b66\u53cd\u5e94\u3002<\/span><\/p>\n

3.\u6839\u636e\u4e0d\u540c\u75be\u75c5\u79cd\u7c7b\u548c\u5206\u671f\uff0c\u9009\u62e9\u521d\u59cb\u6cbb\u7597\u5242\u91cf\uff0c\u6cbb\u7597\u4e2d\u6839\u636e\u7597\u6548\u548c\u4e0d\u826f\u53cd\u5e94\u8c03\u6574\u5242\u91cf\u3002<\/span><\/p>\n

4.\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0c\u8840\u5c0f\u677f\u51cf\u5c11\uff0c\u8d2b\u8840\uff0c\u80f8\u8154\u79ef\u6db2\uff0c\u5934\u75db\uff0c\u8179\u6cfb\uff0c\u75b2\u52b3\u7b49\uff0c\u5c11\u6570\u6709\u80ba\u52a8\u8109\u9ad8\u538b\u3002<\/span><\/p>\n

5.\u672c\u54c1\u662fCYP3A4\u7684\u5e95\u7269\uff0c\u4e0e\u5f3a\u6548\u6291\u5236CYP3A4\u7684\u836f\u7269\u540c\u65f6\u4f7f\u7528\u53ef\u589e\u52a0\u672c\u54c1\u7684\u66b4\u9732\u5242\u91cf\u3002\u56e0\u6b64\uff0c\u4e0d\u63a8\u8350\u540c\u65f6\u7ecf\u5168\u8eab\u7ed9\u4e88\u5f3a\u6548\u7684CYP3A4\u6291\u5236\u5242\u3002\u5982\u679c\u65e0\u6cd5\u907f\u514d\u5408\u5e76\u7528\u836f\uff0c\u5219\u5e94\u5bf9\u6bd2\u6027\u53cd\u5e94\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002<\/span><\/p>\n

\u4e09\u3001\u5c3c\u6d1b\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u5c3c\u6d1b\u66ff\u5c3c\u80f6\u56ca<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u80f6\u56ca\uff1a150mg\u3001200mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u65b0\u8bca\u65ad\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff08Ph+CML\uff09\u6162\u6027\u671f\u6210\u4eba\u60a3\u8005\u3002<\/span><\/p>\n

2.\u5bf9\u65e2\u5f80\u6cbb\u7597\uff08\u5305\u62ec\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\uff09\u8010\u836f\u6216\u4e0d\u8010\u53d7\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684Ph+CML\u6162\u6027\u671f\u6216\u52a0\u901f\u671f\u6210\u4eba\u60a3\u8005\u3002<\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u5c3c\u6d1b\u66ff\u5c3c\u4e0d\u53ef\u7528\u4e8e\u4f4e\u8840\u94be\u3001\u4f4e\u8840\u9541\u6216\u957fQT\u7efc\u5408\u5f81\u7684\u60a3\u8005\u3002\u5728\u4f7f\u7528\u5c3c\u6d1b\u66ff\u5c3c\u4ee5\u524d\u5fc5\u987b\u7ea0\u6b63\u4f4e\u94be\u548c\u4f4e\u9541\uff0c\u5e76\u5b9a\u671f\u8fdb\u884c\u76d1\u6d4b\u3002<\/span><\/p>\n

2.\u907f\u514d\u5408\u7528\u5df2\u77e5\u7684\u53ef\u5ef6\u957fQT\u95f4\u671f\u7684\u836f\u7269\u548cCYP3A4\u7684\u5f3a\u6548\u6291\u5236\u5242\u3002<\/span><\/p>\n

3.\u6709\u809d\u529f\u80fd\u635f\u5bb3\u7684\u60a3\u8005\u5efa\u8bae\u51cf\u91cf\u3002<\/span><\/p>\n

4.\u5728\u5f00\u59cb\u7ed9\u836f\u524d\u3001\u5f00\u59cb\u7ed9\u836f\u540e7\u5929\u4ee5\u53ca\u4e4b\u540e\u65f6\u95f4\u91cc\u5b9a\u671f\u8fdb\u884c\u5fc3\u7535\u56fe\u68c0\u67e5\u4ee5\u76d1\u6d4bQTc\uff0c\u5e76\u4e14\u5728\u4efb\u4f55\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u65f6\u4e5f\u5e94\u5982\u6b64\u3002<\/span><\/p>\n

\u56db\u3001\u5229\u59a5\u6614\u5355\u6297<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u5229\u59a5\u6614\u5355\u6297\u6ce8\u5c04\u6db2<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/strong>\uff1a\u9488\u5242\uff1a100\uff0810ml\uff09\/\u74f6\u3001500mg\uff0850ml\uff09\/\u74f6<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u590d\u53d1\u6216\u8010\u836f\u7684\u6ee4\u6ce1\u6027\u4e2d\u592e\u578b\u6dcb\u5df4\u7624\uff08\u56fd\u9645\u5de5\u4f5c\u5206\u7c7bB\u3001C\u548cD\u4e9a\u578b\u7684B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff09\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

2.\u5148\u524d\u672a\u7ecf\u6cbb\u7597\u7684CD20\u9633\u6027\u2162\uff5e\u2163\u671f\u6ee4\u6ce1\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u60a3\u8005\u5e94\u4e0e\u5316\u7597\u8054\u5408\u4f7f\u7528\u3002<\/span><\/p>\n

3.CD20\u9633\u6027\u5f25\u6f2b\u5927B\u7ec6\u80de\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u5e94\u4e0e\u6807\u51c6CHOP\u5316\u7597\uff08\u73af\u78f7\u9170\u80fa\u3001\u963f\u9709\u7d20\u3001\u957f\u6625\u65b0\u78b1\u3001\u5f3a\u7684\u677e\uff098\u4e2a\u5468\u671f\u8054\u5408\u6cbb\u7597\u3002<\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u63a5\u53d7\u5229\u59a5\u6614\u5355\u6297\u6cbb\u7597\u540e\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\uff0c<\/span>\u4e3b\u8981\u5728\u9996\u6b21\u8f93\u6ce8\u65f6\u53d1\u751f\uff0c\u75c7\u72b6\u53ef\u8868\u73b0\u4e3a\uff1a\u6076\u5fc3\u3001\u7619\u75d2\u3001\u53d1\u70ed\u3001\u98ce\u75b9\/\u76ae\u75b9\u3001\u754f\u5bd2\u3001\u70ed\u75c5\u3001\u5bd2\u6218\u3001\u55b7\u568f\u3001\u8840\u7ba1\u795e\u7ecf\u6027\u6c34\u80bf\u3001\u54bd\u5589\u523a\u6fc0\u3001\u54b3\u55fd\u548c\u652f\u6c14\u7ba1\u75c9\u631b\uff0c\u540c\u65f6\u4f34\u6709\u6216\u4e0d\u4f34\u6709\u4e0e\u836f\u7269\u6cbb\u7597\u76f8\u5173\u7684\u4f4e\u8840\u538b\u6216\u9ad8\u8840\u538b<\/span>\u3002\u6bcf\u6b21\u6ef4\u6ce8\u5229\u59a5\u6614\u5355\u6297\u524d\u5e94\u9884\u5148\u4f7f\u7528\u6297\u8fc7\u654f\u836f\u7269\u3002\u5982\u679c\u6240\u4f7f\u7528\u7684\u6cbb\u7597\u65b9\u6848\u4e0d\u5305\u62ec\u76ae\u8d28\u6fc0\u7d20\u65f6\uff0c\u8fd8\u5e94\u8be5\u9884\u5148\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3002<\/span><\/p>\n

2.<\/span>\u5728\u63a5\u53d7\u5229\u59a5\u6614\u5355\u6297\u548c\u7ec6\u80de\u589e\u6b96\u6291\u5236\u836f\u5316\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u5df2\u62a5\u544a\u53d1\u751f\u4e59\u578b\u809d\u708e\u518d\u6fc0\u6d3b\u7684\u75c5\u4f8b\u3002\u5e94\u5728\u5f00\u59cb\u5229\u59a5\u6614\u5355\u6297\u6cbb\u7597\u524d\u5bf9\u6240\u6709\u60a3\u8005\u6839\u636e\u5f53\u5730\u6307\u5357\u8fdb\u884c\u4e59\u809d\u75c5\u6bd2\uff08HBV\uff09\u7684\u7b5b\u67e5\uff0c\u81f3\u5c11\u5e94\u5305\u62ec\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u548c\u4e59\u809d\u6838\u5fc3\u6297\u4f53\uff08HBcAb\uff09\u6307\u6807\u3002\u4e0d\u5e94\u5bf9\u6d3b\u52a8\u6027\u4e59\u809d\u60a3\u8005\u4f7f\u7528\u5229\u59a5\u6614\u5355\u6297\u8fdb\u884c\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

3.\u7981\u7528\u4e8e\u4e25\u91cd\u6d3b\u52a8\u6027\u611f\u67d3\u6216\u514d\u75ab\u5e94\u7b54\u4e25\u91cd\u635f\u5bb3\uff08\u5982\u4f4e\u7403\u86cb\u767d\u8840\u75c7\uff0cCD4\u6216CD8\u7ec6\u80de\u8ba1\u6570\u4e25\u91cd\u4e0b\u964d\uff09\u60a3\u8005\u53ca\u4e25\u91cd\u5fc3\u8870[\u7ebd\u7ea6\u5fc3\u810f\u75c5\u5b66\u4f1a\uff08NYHA\uff09<\/span>\u5206\u7c7b\u2163\u7ea7]<\/span>\u60a3\u8005\uff1b\u598a\u5a20\u671f\u95f4\u7981\u6b62\u5229\u59a5\u6614\u5355\u6297\u4e0e\u7532\u6c28\u8776\u5464\u8054\u5408\u7528\u836f\u3002<\/span><\/p>\n

4.\u5bf9\u7528\u836f\u60a3\u8005\u8fdb\u884c\u4e25\u5bc6\u76d1\u62a4\uff0c\u76d1\u6d4b\u662f\u5426\u53d1\u751f\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u53ca\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u3002<\/span><\/p>\n

5.\u9884\u5148\u5b58\u5728\u80ba\u529f\u80fd\u4e0d\u5168\u6216\u80bf\u7624\u80ba\u6d78\u6da6\u7684\u60a3\u8005\u5fc5\u987b\u8fdb\u884c\u80f8\u90e8X\u7ebf\u68c0\u67e5\u3002<\/span><\/p>\n

6.\u74f6\u88c5\u5236\u5242\u4fdd\u5b58\u57282\uff5e8\u2103\u3002<\/span><\/p>\n

\u4e94\u3001\u897f\u8fbe\u672c\u80fa<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u897f\u8fbe\u672c\u80fa\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a5mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u9002\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u6b21\u5168\u8eab\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u7684\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\uff08PTCL\uff09\u60a3\u8005\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.<\/span>\u6210\u4eba\u63a8\u8350\u6bcf\u6b21\u670d\u836f30mg\uff0c\u6bcf\u5468\u670d\u836f\u4e24\u6b21\uff0c\u4e24\u6b21\u670d\u836f\u95f4\u9694\u4e0d\u5e94\u5c11\u4e8e3\u5929\uff08\u5982\u5468\u4e00\u548c\u5468\u56db\u3001\u5468\u4e8c\u548c\u5468\u4e94\u3001\u5468\u4e09\u548c\u5468\u516d\u7b49\uff09\uff0c\u65e9\u9910\u540e30\u5206\u949f\u670d\u7528\u3002\u82e5\u75c5\u60c5\u672a\u8fdb\u5c55\u6216\u672a\u51fa\u73b0\u4e0d\u80fd\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5efa\u8bae\u6301\u7eed\u670d\u836f\u3002<\/span><\/span><\/p>\n

2.\u5242\u91cf\u8c03\u6574\uff1a3\u7ea7\u62164\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff08\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\uff1c1.0\u00d7109<\/sup>\/L\uff09\u3001\u8840\u5c0f\u677f\u51cf\u5c11\uff08\u8840\u5c0f\u677f\u8ba1\u6570\uff1c50.0\u00d7109<\/sup>\/L\uff09\u3001\u8d2b\u8840\uff08\u8840\u7ea2\u86cb\u767d\u964d\u4f4e\u81f3\uff1c8.0g\/dl\uff09\u65f6\uff0c\u6682\u505c\u7528\u836f\u3002\u5f85\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u503c\u6062\u590d\u81f3\u22651.5\u00d7109<\/sup>\/L\u3001\u8840\u5c0f\u677f\u6062\u590d\u81f3\u226575.0\u00d7109<\/sup>\/L\u3001\u8840\u7ea2\u86cb\u767d\u6062\u590d\u81f3\u22659.0g\/dl\uff0c\u5e76\u7ecf\u8fde\u7eed\u4e24\u6b21\u68c0\u67e5\u786e\u8ba4\uff0c\u53ef\u7ee7\u7eed\u6cbb\u7597\u3002\u5982\u4e4b\u524d\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a3\u7ea7\uff0c\u6062\u590d\u7528\u836f\u65f6\u53ef\u91c7\u7528\u539f\u5242\u91cf\u6216\u5242\u91cf\u964d\u4f4e\u81f320mg\/\u6b21\uff1b\u5982\u4e4b\u524d\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a4\u7ea7\uff0c\u6062\u590d\u7528\u836f\u65f6\u5242\u91cf\u5e94\u964d\u4f4e\u81f320mg\/\u6b21\u3002<\/span><\/p>\n

3.\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u6709\uff1a\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8840\u5c0f\u677f\u8ba1\u6570\u51cf\u5c11\u3001\u767d\u7ec6\u80de\u6216\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u3001\u8840\u7ea2\u86cb\u767d\u964d\u4f4e\uff1b\u5168\u8eab\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u4e4f\u529b\u3001\u53d1\u70ed\uff1b\u80c3\u80a0\u9053\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8179\u6cfb\u3001\u6076\u5fc3\u548c\u5455\u5410\uff1b\u4ee3\u8c22\u53ca\u8425\u517b\u7cfb\u7edf\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u98df\u6b32\u4e0b\u964d\u3001\u4f4e\u94be\u8840\u75c7\u548c\u4f4e\u9499\u8840\u75c7\uff1b\u4ee5\u53ca\u5934\u6655\u3001\u76ae\u75b9\u7b49\uff1b\u6781\u5c11\u6570\u60a3\u8005\u5fc3\u7535\u56fe\u4f1a\u51fa\u73b0Q-T\u95f4\u671f\u5ef6\u957f\u3002<\/span><\/p>\n

4.\u598a\u5a20\u671f\u5973\u6027\u60a3\u8005\u3001\u4e25\u91cd\u5fc3\u529f\u80fd\u4e0d\u5168\u60a3\u8005\uff08NYHA\u5fc3\u529f\u80fd\u4e0d\u5168\u5206\u7ea7\u2163\u7ea7\uff09\u7981\u7528\u3002<\/span><\/p>\n

\u516d\u3001\u4f0a\u5e03\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u4f0a\u5e03\u66ff\u5c3c\u80f6\u56ca<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u80f6\u56ca\uff1a140mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u5355\u836f\u9002\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

2.\u5355\u836f\u9002\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

3.\u590d\u53d1\u96be\u6cbb\u7684\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff0c\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\u53canon-GCB\u4e9a\u578b\u7684\u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u3002<\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u6216\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff0c\u6839\u636e\u8bca\u65ad\u4e0d\u540c\uff0c\u6cbb\u7597\u5242\u91cf\u4e0d\u540c\u3002<\/span><\/p>\n

2.\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<\/span><\/p>\n

3.\u6cbb\u7597MCL\u7684\u63a8\u8350\u5242\u91cf\u4e3a560mg\uff0c\u6bcf\u65e5\u4e00\u6b21\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\uff1b\u6cbb\u7597CLL\/SLL\u7684\u63a8\u8350\u5242\u91cf\u4e3a420mg\uff0c\u6bcf\u65e5\u4e00\u6b21\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u3002<\/span><\/span><\/p>\n

4.<\/span>\u8f7b\u5ea6\u809d\u635f\u4f24\u60a3\u8005\uff08Child-Pugh A\u7ea7\uff09\u7684\u63a8\u8350\u5242\u91cf\u662f\u6bcf\u5929140mg\u3002\u4e2d\u5ea6\u6216\u91cd\u5ea6\u809d\u635f\u4f24\u60a3\u8005\uff08Child-Pugh B\u7ea7\u548cC\u7ea7\uff09\u5e94\u907f\u514d\u4f7f\u7528\u3002<\/span><\/span><\/p>\n

5.\u53e3\u670d\u7ed9\u836f\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u6bcf\u5929\u7684\u7528\u836f\u65f6\u95f4\u5927\u81f4\u56fa\u5b9a\u3002\u5e94\u7528\u6c34\u9001\u670d\u6574\u7c92\u80f6\u56ca\u3002\u8bf7\u52ff\u6253\u5f00\u3001\u5f04\u7834\u6216\u5480\u56bc\u80f6\u56ca\u3002\u5982\u679c\u672a\u5728\u8ba1\u5212\u65f6\u95f4\u670d\u7528\u672c\u54c1\uff0c\u53ef\u4ee5\u5728\u5f53\u5929\u5c3d\u5feb\u670d\u7528\uff0c\u7b2c\u4e8c\u5929\u7ee7\u7eed\u5728\u6b63\u5e38\u8ba1\u5212\u65f6\u95f4\u670d\u836f\u3002\u8bf7\u52ff\u989d\u5916\u670d\u7528\u672c\u54c1\u4ee5\u5f25\u8865\u6f0f\u670d\u5242\u91cf\u3002<\/span><\/p>\n

6.\u51fa\u73b0\u4efb\u4f55\u22653\u7ea7\u975e\u8840\u6db2\u5b66\u6bd2\u6027\u3001\u22653\u7ea7\u4f34\u611f\u67d3\u6216\u53d1\u70ed\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u6216\u80054\u7ea7\u8840\u6db2\u5b66\u6bd2\u6027\u65f6\uff0c\u5e94\u4e2d\u65ad\u6cbb\u7597\u3002\u5f85\u6bd2\u6027\u75c7\u72b6\u6d88\u9000\u81f31\u7ea7\u6216\u57fa\u7ebf\u6c34\u5e73\uff08\u6062\u590d\uff09\u65f6\uff0c\u53ef\u4ee5\u8d77\u59cb\u5242\u91cf\u91cd\u65b0\u5f00\u59cb\u6cbb\u7597\u3002\u5982\u679c\u8be5\u6bd2\u6027\u518d\u6b21\u53d1\u751f\uff0c\u5e94\u5c06\u5242\u91cf\u51cf\u5c11140mg,\u5982\u6709\u9700\u8981\uff0c\u53ef\u4ee5\u8003\u8651\u518d\u51cf\u5c11140mg\u3002\u5982\u679c\u5728\u4e24\u6b21\u5242\u91cf\u964d\u4f4e\u540e\u8be5\u6bd2\u6027\u4ecd\u7136\u5b58\u5728\u6216\u518d\u6b21\u53d1\u751f\uff0c\u5e94\u505c\u7528\u3002<\/span><\/p>\n

7.\u63a5\u53d7\u672c\u836f\u6cbb\u7597\u7684MCL\u60a3\u8005\u6700\u5e38\u53d1\u751f\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u226520%\uff09\u662f\u8179\u6cfb\u3001\u51fa\u8840\uff08\u5982\u9752\u80bf\uff09\u3001\u75b2\u4e4f\u3001\u9aa8\u9abc\u808c\u8089\u75bc\u75db\u3001\u6076\u5fc3\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u54b3\u55fd\u548c\u76ae\u75b9\u3002\u6700\u5e38\u89c1\u76843\u7ea7\u62164\u7ea7\u4e0d\u826f\u53cd\u5e94\uff08\u22655%\uff09\u662f\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u611f\u67d3\u6027\u80ba\u708e\u548c\u8d2b\u8840\u3002\u63a5\u53d7\u672c\u836f\u6cbb\u7597\u7684CLL\u6216SLL\u60a3\u8005\u6700\u5e38\u53d1\u751f\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u226520%\uff09\u662f\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u8d2b\u8840\u3001\u8179\u6cfb\u3001\u9aa8\u9abc\u808c\u8089\u75bc\u75db\u3001\u6076\u5fc3\u3001\u76ae\u75b9\u3001\u9752\u80bf\u3001\u75b2\u4e4f\u3001\u53d1\u70ed\u548c\u51fa\u8840\u3002<\/span><\/span><\/p>\n

8.\u907f\u514d\u4e0e\u5f3a\u6548\u6216\u4e2d\u6548CYP3A\u6291\u5236\u5242\u540c\u65f6\u7ed9\u836f\uff0c\u53ef\u8003\u8651\u4f7f\u7528CYP3A\u6291\u5236\u4f5c\u7528\u8f83\u5c0f\u7684\u66ff\u4ee3\u836f\u7269\u3002<\/span><\/p>\n

9.\u7528\u836f\u671f\u95f4\u7981\u6b62\u670d\u7528\u585e\u5c14\u7ef4\u4e9a\u6a59\u6216\u8461\u8404\u67da\u3002<\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>10.\u4e00\u7ebf\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff0c\u96be\u6cbb\u590d\u53d1\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff0c\u6162\u6027\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff08\u7f8e\u56fdFDA\u6279\u51c6\u7684\u5176\u4ed6\u9002\u5e94\u8bc1\uff09\u3002<\/span><\/span><\/p>\n

\u4e03\u3001\u787c\u66ff\u4f50\u7c73<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u6ce8\u5c04\u7528\u787c\u66ff\u4f50\u7c73<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u9488\u5242\uff1a1mg\u30013.5mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u590d\u53d1\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u3002<\/span><\/p>\n

2.\u521d\u6cbb\u53ca\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u5e94\u7528\u787c\u66ff\u4f50\u7c73\u4e3a\u57fa\u7840\u7684\u65b9\u6848\u8fdb\u884c\u6cbb\u7597\u8981\u6ce8\u610f\u8fdb\u884c\u795e\u7ecf\u7cfb\u7edf\u75c7\u72b6\uff08\u5305\u62ec\u80a0\u6897\u963b\uff09\u3001\u75c5\u6bd2\u6fc0\u6d3b\u3001\u8840\u6db2\u7cfb\u7edf\u9aa8\u9ad3\u6291\u5236\u7b49\u7684\u76d1\u63a7\u3002<\/span><\/p>\n

2.\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4f7f\u7528\u65e0\u9700\u51cf\u91cf\uff0c\u8fdb\u884c\u900f\u6790\u7684\u60a3\u8005\u5e94\u5728\u900f\u6790\u540e\u4f7f\u7528\u3002<\/span><\/p>\n

3.\u672c\u54c1\u662fCYP3A4\u7684\u5e95\u7269\uff0c\u4e0e\u5f3a\u6548\u6291\u5236CYP3A4\u7684\u836f\u7269\u540c\u65f6\u4f7f\u7528\u53ef\u589e\u52a0\u672c\u54c1\u7684\u66b4\u9732\u5242\u91cf\u3002\u56e0\u6b64\uff0c\u4e0d\u63a8\u8350\u540c\u65f6\u7ecf\u5168\u8eab\u7ed9\u4e88\u5f3a\u6548\u7684CYP3A4\u6291\u5236\u5242\u3002\u5982\u679c\u65e0\u6cd5\u907f\u514d\u5408\u5e76\u7528\u836f\uff0c\u5219\u5e94\u5bf9\u6bd2\u6027\u53cd\u5e94\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002<\/span><\/p>\n

4.\u787c\u66ff\u4f50\u7c73\u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u4e0e\u9759\u8109\u63a8\u6ce8\u540c\u6837\u7684\u7597\u6548\uff0c\u4e14\u795e\u7ecf\u75c5\u53d8\u53d1\u751f\u7387\u66f4\u4f4e\u3002<\/span><\/p>\n

5.\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u9700\u8981\u5177\u6709\u6cbb\u7597\u6307\u5f81\uff0c\u5373\u4ee5\u4e0b\u5176\u4e2d\u4e4b\u4e00\uff1a\u80be\u529f\u80fd\u5f02\u5e38\u3001\u8840\u9499\u5347\u9ad8\u3001\u8d2b\u8840\u53ca\u9aa8\u8d28\u7834\u574f\u3001\u8840\u6e05\u6e38\u79bb\u8f7b\u94fe\u6bd4\u503c\u5927\u4e8e100\u3001\u9aa8\u9ad3\u4e2d\u514b\u9686\u6d46\u7ec6\u80de\u5927\u4e8e60%\u3001\u6838\u78c1\u8bc1\u5b9e2\u5904\u6216\u4ee5\u4e0a\u9aa8\u8d28\u7834\u574f\u624d\u9700\u8981\u6cbb\u7597\u3002\u4e0d\u7b26\u5408\u4ee5\u4e0a\u6807\u51c6\u7684\u5192\u70df\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u76ee\u524d\u4e0d\u5efa\u8bae\u8fdb\u884c\u6cbb\u7597\uff0c\u5305\u62ec\u787c\u66ff\u4f50\u7c73\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>6.\u787c\u66ff\u4f50\u7c73\u5e94\u7528\u4e8e\u521d\u6cbb\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08FDA\u5df2\u83b7\u6279\uff0c\u57fa\u4e8eLYM-3002\u7814\u7a76\uff09\u3002<\/span><\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>7.\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08FDA\u5df2\u6279\u51c6\uff09\u3002<\/span><\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>8.\u5176\u4ed6\u7f55\u89c1\u6d46\u7ec6\u80de\u75c5\uff0c\u5982\u8f7b\u94fe\u578b\u6dc0\u7c89\u6837\u53d8\u6027\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u6570\u636e\uff09\u3001POEMS\uff08\u4ec5\u2160\uff5e\u2161\u671f\u6570\u636e\uff09\u3001MGRS\uff08\u610f\u4e49\u672a\u660e\u5355\u514b\u9686\u514d\u75ab\u7403\u86cb\u767d\u8840\u75c7\u4f34\u80be\u810f\u635f\u5bb3\uff0c\u4ec5\u6709\u2160\uff5e\u2161\u671f\u6570\u636e\uff09\u7b49\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>9.\u787c\u66ff\u4f50\u7c73\u5bf9\u4e8e\u6d3b\u52a8\u6027\u9aa8\u9ad3\u7624\u7684\u76ae\u4e0b\u4f7f\u7528\uff08\u5168\u7403\u5176\u4ed6\u56fd\u5bb6\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<\/span><\/span><\/p>\n

\u516b\u3001\u6765\u90a3\u5ea6\u80fa<\/span><\/strong><\/p>\n

\u901a\u7528\u540d<\/span><\/strong>\uff1a<\/span><\/strong>\u6765\u90a3\u5ea6\u80fa\u80f6\u56ca<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/strong>\uff1a<\/span><\/strong>\u80f6\u56ca\uff1a10mg\u300125mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u521d\u6cbb\u53ca\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u6765\u90a3\u5ea6\u80fa\u5e94\u7528\u540e\u9700\u8981\u76d1\u6d4b\u8840\u5e38\u89c4\uff0c\u53d1\u751f\u9aa8\u9ad3\u6291\u5236\u3001\u8840\u7ec6\u80de\u51cf\u5c11\u4e3a\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u3002<\/span><\/p>\n

2.\u5bf9\u4e8e\u9002\u5408\u63a5\u6536\u81ea\u4f53\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u75c5\u4eba\uff0c\u79fb\u690d\u524d\u5efa\u8bae\u63a5\u53d7\u4e0d\u8981\u8d85\u8fc74\u4e2a\u7597\u7a0b\u542b\u6709\u6765\u90a3\u5ea6\u80fa\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

3.\u787c\u66ff\u4f50\u7c73\u4e0e\u6765\u90a3\u5ea6\u80fa\u5177\u6709\u534f\u540c\u4f5c\u7528\u3002<\/span><\/p>\n

4.\u80be\u529f\u80fd\u4e0d\u5168\u7684\u9aa8\u9ad3\u7624\u60a3\u8005\u5e94\u7528\u540e\u9700\u8981\u51cf\u91cf\u3002<\/span><\/p>\n

5.\u957f\u671f\u5e94\u7528\u4f1a\u589e\u52a0\u7b2c\u4e8c\u80bf\u7624\u7684\u98ce\u9669\u3002<\/span><\/p>\n

6.\u5bf9\u4e8e\u63a5\u53d7\u6765\u90a3\u5ea6\u80fa\u4e0e\u5730\u585e\u7c73\u677e\u6cbb\u7597\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u800c\u8a00\uff0c\u6df1\u9759\u8109\u8840\u6813\u548c\u80ba\u6813\u585e\u7684\u98ce\u9669\u663e\u8457\u5347\u9ad8\u3002\u9700\u8981\u5bc6\u5207\u6ce8\u610f\u8840\u6813\u5bfc\u81f4\u7684\u75c7\u72b6\u548c\u4f53\u5f81\uff0c\u5408\u5e76\u9ad8\u5371\u8840\u6813\u98ce\u9669\u65f6\u5efa\u8bae\u7ed9\u4e88\u9884\u9632\u6027\u6297\u51dd\u3002<\/span><\/p>\n

7.\u53ef\u80fd\u4f1a\u6709\u80da\u80ce-\u751f\u6b96\u6bd2\u6027\uff0c\u4f7f\u7528\u671f\u95f4\u6ce8\u610f\u907f\u5b55\u3002<\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>8.\u6ee4\u6ce1\u7ec6\u80de\u6dcb\u5df4\u7624\uff08\u5168\u7403\u5176\u4ed6\u56fd\u5bb6\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<\/span><\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>9.POEMS\u7efc\u5408\u5f81\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002<\/span><\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>10.\u8f7b\u94fe\u6dc0\u7c89\u6837\u53d8\u6027\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002<\/span><\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>11.MGRS\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002<\/span><\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>12.del\uff085q\uff09\u7684\u4f4e\u5371\/\u4e2d\u53711\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002<\/span><\/span><\/p>\n

\u4e5d\u3001\u6c99\u5229\u5ea6\u80fa<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u6c99\u5229\u5ea6\u80fa\u7247\uff0c\u6c99\u5229\u5ea6\u80fa\u80f6\u56ca<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\uff081\uff09\u7247\u5242\uff1a25mg\uff1b\uff082\uff09\u80f6\u56ca\uff1a25mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u9ebb\u98ce\u75c5\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u6c99\u5229\u5ea6\u80fa\u53ef\u4ee5\u5f15\u8d77\u5fc3\u7387\u51cf\u6162\uff0c\u4e25\u91cd\u8005\u51fa\u73b0\u4e09\u5ea6\u623f\u5ba4\u4f20\u5bfc\u963b\u6ede\u3002<\/span><\/p>\n

2.\u76ae\u75b9\u4ee5\u53ca\u4fbf\u79d8\u3001\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u4e3a\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u901a\u8fc7\u51cf\u91cf\u4ee5\u53ca\u8f85\u52a9\u7528\u836f\u7f13\u89e3\u3002<\/span><\/p>\n

3.\u787c\u66ff\u4f50\u7c73\u4e0e\u6c99\u5229\u5ea6\u80fa\u5177\u6709\u534f\u540c\u4f5c\u7528\u3002<\/span><\/p>\n

4.\u5bf9\u4e8e\u63a5\u53d7\u6c99\u5229\u5ea6\u80fa\u4e0e\u5730\u585e\u7c73\u677e\u6cbb\u7597\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u800c\u8a00\uff0c\u6df1\u9759\u8109\u8840\u6813\u548c\u80ba\u6813\u585e\u7684\u98ce\u9669\u663e\u8457\u5347\u9ad8\u3002\u9700\u8981\u5bc6\u5207\u6ce8\u610f\u8840\u6813\u5bfc\u81f4\u7684\u75c7\u72b6\u548c\u4f53\u5f81\uff0c\u5408\u5e76\u9ad8\u5371\u8840\u6813\u98ce\u9669\u65f6\u5efa\u8bae\u7ed9\u4e88\u9884\u9632\u6027\u6297\u51dd\u3002<\/span><\/p>\n

5.\u7ec6\u80de\u9057\u4f20\u5b66\u9ad8\u5371\u60a3\u8005\u4e0d\u5efa\u8bae\u5355\u72ec\u4f7f\u7528\u6c99\u5229\u5ea6\u80fa\u8fdb\u884c\u7ef4\u6301\u6cbb\u7597\u3002<\/span><\/p>\n

6.\u6709\u80da\u80ce-\u751f\u6b96\u6bd2\u6027\uff0c\u5b55\u671f\u5987\u5973\u53ef\u5f15\u8d77\u80ce\u513f\u6d77\u8c79\u7578\u5f62\uff0c\u5e94\u6ce8\u610f\u907f\u5b55\u3002<\/span><\/p>\n

7.\u670d\u7528\u540e\u4f1a\u51fa\u73b0\u55dc\u7761\uff0c\u7729\u6655\uff0c\u4e0d\u5efa\u8bae\u5f00\u8f66\uff0c\u5e94\u4e34\u7761\u524d\u670d\u7528\u3002<\/span><\/p>\n

\u203b<\/span><\/sup><\/strong>8.\u6c99\u5229\u5ea6\u80fa\u53ef\u4ee5\u7528\u4e8e\u521d\u6cbb\u53ca\u96be\u6cbb\u590d\u53d1\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u75c5\u4eba\uff08\u5728\u56fd\u5916\u5927\u591a\u6570\u56fd\u5bb6\u90fd\u5df2\u7ecf\u6279\u51c6\u7528\u4e8e\u521d\u6cbb\u4ee5\u53ca\u96be\u6cbb\u590d\u53d1\u9aa8\u9ad3\u7624\u6cbb\u7597\uff09\u3002<\/span><\/span><\/p>\n

\u5341\u3001\u82a6\u53ef\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u78f7\u9178\u82a6\u53ef\u66ff\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a5mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u7528\u4e8e\u4e2d\u5371\u6216\u9ad8\u5371\u7684\u539f\u53d1\u6027\u9aa8\u9ad3\u7ea4\u7ef4\u5316\uff08PMF\uff09\uff08\u4ea6\u79f0\u4e3a\u6162\u6027\u7279\u53d1\u6027\u9aa8\u9ad3\u7ea4\u7ef4\u5316\uff09\u3001\u771f\u6027\u7ea2\u7ec6\u80de\u589e\u591a\u75c7\u7ee7\u53d1\u7684\u9aa8\u9ad3\u7ea4\u7ef4\u5316\uff08PPV-MF\uff09\u6216\u539f\u53d1\u6027\u8840\u5c0f\u677f\u589e\u591a\u75c7\u7ee7\u53d1\u7684\u9aa8\u9ad3\u7ea4\u7ef4\u5316\uff08PET-MF\uff09\u7684\u6210\u5e74\u60a3\u8005\uff0c\u6cbb\u7597\u75be\u75c5\u76f8\u5173\u813e\u80bf\u5927\u6216\u75be\u75c5\u76f8\u5173\u75c7\u72b6\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9<\/span><\/strong>\uff1a<\/span><\/span><\/p>\n

1.\u6cbb\u7597\u5242\u91cf\uff1a\u6309\u7167\u8840\u5c0f\u677f\u8ba1\u6570\u7ed9\u4e88\u8d77\u59cb\u5242\u91cf\u3002\uff081\uff09\u8840\u5c0f\u677f\u8ba1\u6570\u5728100 000\uff5e200000\/mm3<\/sup>\uff0c\u8d77\u59cb\u5242\u91cf\u4e3a15mg\uff0c\u6bcf\u65e5\u4e24\u6b21\u3002\uff082\uff09\u8840\u5c0f\u677f\u8ba1\u6570\uff1e200 000\/mm3<\/sup>\uff0c\u8d77\u59cb\u5242\u91cf\u4e3a20mg\uff0c\u6bcf\u65e5\u4e24\u6b21\u3002\uff083\uff09\u8840\u5c0f\u677f\u8ba1\u6570\u572850000\uff5e100 000\/mm3<\/sup>\uff0c\u8d77\u59cb\u5242\u91cf\u4e3a5mg\uff0c\u6bcf\u65e5\u4e24\u6b21\u3002<\/span><\/p>\n

2.\u672c\u54c1\u53ef\u80fd\u9020\u6210\u8840\u6db2\u7cfb\u7edf\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3002\u6cbb\u7597\u524d\uff0c\u5fc5\u987b\u8fdb\u884c\u5168\u8840\u7ec6\u80de\u8ba1\u6570\u68c0\u67e5\uff0c\u4e4b\u540e\u6bcf\u5468\u76d1\u6d4b\u4e00\u6b21\uff0c4\u5468\u540e\u53ef\u6bcf2\uff5e4\u5468\u76d1\u6d4b\u4e00\u6b21\uff0c\u76f4\u5230\u8fbe\u5230\u7a33\u5b9a\uff0c\u7136\u540e\u53ef\u4ee5\u6839\u636e\u4e34\u5e8a\u9700\u8981\u8fdb\u884c\u76d1\u6d4b\u3002\u5f53\u51fa\u73b0\u8840\u5c0f\u677f\u51cf\u5c11\u6216\u8d2b\u8840\u65f6\uff0c\u53ef\u51cf\u5c11\u5242\u91cf\u6216\u6682\u65f6\u505c\u6b62\u7528\u836f\uff0c\u5fc5\u8981\u65f6\u8f93\u6ce8\u8840\u5c0f\u677f\u6216\u7ea2\u7ec6\u80de\u3002<\/span><\/p>\n

3.\u4e2d\u65ad\u6216\u7ec8\u6b62\u672c\u54c1\u6cbb\u7597\u540e\uff0c\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u7684\u75c7\u72b6\u53ef\u80fd\u5728\u5927\u7ea6\u4e00\u5468\u540e\u518d\u6b21\u51fa\u73b0\u3002\u82e5\u975e\u5fc5\u987b\u7d27\u6025\u7ec8\u6b62\u6cbb\u7597\uff0c\u5e94\u53ef\u4ee5\u8003\u8651\u9010\u6b65\u51cf\u5c11\u672c\u54c1\u7684\u7528\u836f\u5242\u91cf\u3002<\/span><\/p>\n

4.\u672c\u54c1\u4e0e\u5f3a\u6548CYP3A4\u6291\u5236\u5242\u6216CYP2C9\u548cCYP3A4\u9176\u53cc\u91cd\u6291\u5236\u5242\u5408\u5e76\u4f7f\u7528\u65f6\uff0c\u6bcf\u65e5\u603b\u5242\u91cf\u5e94\u51cf\u5c11\u7ea650%\u3002<\/span><\/p>\n


<\/p>\n

\u6ccc\u5c3f\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u4e00\u3001\u4f9d\u7ef4\u83ab\u53f8<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u4f9d\u7ef4\u83ab\u53f8\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a5mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u65e2\u5f80\u63a5\u53d7\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c\u6216\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c<\/span>\uff08RCC\uff09\uff0c\u76ee\u524d\u7684\u7814\u7a76\u4e3b\u8981\u57fa\u4e8e\u900f\u660e\u7ec6\u80de\u80be\u764c\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u809d\u529f\u80fd\u53d7\u635f\u4f1a\u4f7f\u4f9d\u7ef4\u83ab\u53f8\u66b4\u9732\u91cf\u589e\u52a0\uff0c\u6309\u5982\u4e0b\u65b9\u5f0f\u8fdb\u884c\u7ed9\u836f\u8c03\u6574\uff1a\uff081\uff09\u8f7b\u5ea6\u809d\u529f\u80fd\u53d7\u635f\uff08Child-Pugh A\u7ea7\uff09\uff1a\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u59297.5mg\uff1b\u5982\u679c\u4e0d\u80fd\u5f88\u597d\u5730\u8010\u53d7\uff0c\u53ef\u5c06\u5242\u91cf\u964d\u81f3\u6bcf\u59295mg\u3002\uff082\uff09\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u635f\uff08Child-Pugh B\u7ea7\uff09\uff1a\u63a8\u8350\u5242\u91cf\u662f\u6bcf\u59295mg\uff1b\u5982\u679c\u4e0d\u80fd\u5f88\u597d\u5730\u8010\u53d7\uff0c\u53ef\u5c06\u5242\u91cf\u964d\u81f3\u6bcf\u59292.5mg\u3002\uff083\uff09\u91cd\u5ea6\u809d\u529f\u80fd\u53d7\u635f\uff08Child-Pugh C\u7ea7\uff09\uff1a\u5982\u679c\u9884\u671f\u7684\u83b7\u76ca\u9ad8\u4e8e\u98ce\u9669\uff0c\u53ef\u4ee5\u91c7\u7528\u6bcf\u59292.5mg\uff0c\u4f46\u4e0d\u5f97\u8d85\u8fc7\u8fd9\u4e00\u5242\u91cf\u3002<\/span><\/p>\n

2.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u53e3\u8154\u708e\u7b49\uff1b\u5e94\u7279\u522b\u6ce8\u610f\u975e\u611f\u67d3\u6027\u80ba\u708e\u7684\u53d1\u751f\u3002<\/span><\/p>\n

3.\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5f3a\u6548CYP3A4\u8bf1\u5bfc\u5242\uff08\u5982\u82ef\u59a5\u82f1\u3001\u5361\u9a6c\u897f\u5e73\u3001\u5229\u798f\u5e73\u3001\u5229\u798f\u5e03\u4e01\u3001\u5229\u798f\u55b7\u6c40\u548c\u82ef\u5df4\u6bd4\u59a5\uff09\u3002<\/span><\/p>\n

4.\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u5e94\u907f\u514d\u63a5\u79cd\u6d3b\u75ab\u82d7\uff0c\u907f\u514d\u4e0e\u63a5\u79cd\u8fc7\u6d3b\u75ab\u82d7\u7684\u4eba\u5bc6\u5207\u63a5\u89e6\u3002<\/span><\/p>\n

\u4e8c\u3001\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a200mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u8f6c\u79fb\u6027\u80be\u764c\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7a7a\u8179\u7ed9\u836f\uff0c\u7528\u836f\u524d\u65e0\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u3002<\/span><\/p>\n

2.\u5b58\u5728\u53ef\u7591\u7684\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u548c\/\u6216\u51cf\u5c11\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u5242\u91cf\u3002<\/span><\/p>\n

3.\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u6709\u8179\u6cfb\uff0c\u4e4f\u529b\uff0c\u8131\u53d1\uff0c\u611f\u67d3\uff0c\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\uff0c\u76ae\u75b9\u3002\u907f\u514d\u5e94\u7528CYP3A4\u5f3a\u6548\u6291\u5236\u5242\uff08\u5982\u916e\u5eb7\u5511\u3001\u4f0a\u66f2\u5eb7\u5511\u3001\u514b\u62c9\u9709\u7d20\u3001\u963f\u624e\u90a3\u97e6\u3001\u5948\u6cd5\u5511\u916e\u3001\u6c99\u594e\u90a3\u97e6\u3001\u6cf0\u5229\u9709\u7d20\u3001\u5229\u6258\u90a3\u97e6\u3001\u831a\u5730\u90a3\u97e6\u3001\u5948\u975e\u90a3\u97e6\u3001\u4f0f\u7acb\u5eb7\u5511\uff09\u3002<\/span><\/p>\n

4.\u5bf9\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u6216\u672c\u54c1\u4efb\u4e00\u975e\u6d3b\u6027\u6210\u5206\u6709\u4e25\u91cd\u8fc7\u654f\u75c7\u72b6\u7684\u60a3\u8005\u7981\u7528\u3002<\/span><\/p>\n

5.\u4e0eUGT1A1\u9014\u5f84\u4ee3\u8c22\/\u6e05\u9664\u7684\u836f\u7269\u8054\u5408\u5e94\u7528\u65f6\uff0c\u9700\u8c28\u614e\uff1b\u4e0e\u591a\u897f\u4ed6\u8d5b\u8054\u5408\u5e94\u7528\u65f6\uff0c\u9700\u8c28\u614e\uff1b\u4e0eCYP3A4\u8bf1\u5bfc\u5242\u8054\u5408\u5e94\u7528\u65f6\u53ef\u5bfc\u81f4\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u7684\u836f\u7269\u6d53\u5ea6\u964d\u4f4e\uff1b\u4e0e\u65b0\u9709\u7d20\u8054\u5408\u5e94\u7528\u53ef\u5bfc\u81f4\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u7684\u66b4\u9732\u91cf\u4e0b\u964d\u3002<\/span><\/p>\n

\u4e09\u3001\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d<\/span><\/strong>\uff1a<\/span><\/strong>\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c\u80f6\u56ca<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u80f6\u56ca\uff1a12.5mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u8f6c\u79fb\u6027\u80be\u764c\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u63a8\u8350\u5242\u91cf\u4e3a50mg\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u53e3\u670d\uff0c\u670d\u836f4\u5468\uff0c\u505c\u836f2\u5468\uff084\/2\u7ed9\u836f\u65b9\u6848\uff09\u3002<\/span><\/p>\n

2.\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4ee512.5mg\u4e3a\u68af\u5ea6\u5355\u4f4d\u9010\u6b65\u8c03\u6574\u5242\u91cf\u3002\u6bcf\u65e5\u6700\u9ad8\u5242\u91cf\u4e0d\u8d85\u8fc775mg\uff0c\u6700\u4f4e\u5242\u91cf\u4e3a25mg\u3002\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u60c5\u51b5\u53ef\u80fd\u9700\u8981\u4e2d\u65ad\u6cbb\u7597\u3002<\/span><\/p>\n

3.\u907f\u514d\u4e0e\u5f3a\u6548CYP3A4\/5\u6291\u5236\u5242\uff08\u5982\u916e\u5eb7\u5511\u3001\u4f0a\u66f2\u5eb7\u5511\u3001\u514b\u62c9\u9709\u7d20\u7b49\uff09\u6216\u5f3a\u6548CYP3A4\/5\u8bf1\u5bfc\u5242\uff08\u5982\u5229\u798f\u5e73\u3001\u5730\u585e\u7c73\u677e\u7b49\uff09\u5408\u7528\u3002<\/span><\/p>\n

4.\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c\u670d\u75284\u5468\uff0c\u505c\u836f2\u5468\uff084\/2\u7ed9\u836f\u65b9\u6848\uff09\u53ef\u80fd\u4f1a\u53d1\u73b0\u767d\u7ec6\u80de\u53ca\u8840\u5c0f\u677f\u4e0b\u964d\u7b49\u4e25\u91cd\u9aa8\u9ad3\u6291\u5236\uff0c\u56e0\u6b64\u7528\u836f\u671f\u95f4\u9700\u8981\u5bc6\u5207\u76d1\u6d4b\u8840\u5e38\u89c4\u3002\u5fc5\u8981\u65f6\u53ef\u91c7\u75282\/1\u7ed9\u836f\u65b9\u6848\uff0c\u5373\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c\u670d\u75282\u5468\uff0c\u505c\u836f1\u5468\u3002<\/span><\/p>\n

\u56db\u3001\u963f\u6614\u66ff\u5c3c<\/span><\/p>\n

\u901a\u7528\u540d<\/span><\/strong>\uff1a<\/span><\/strong>\u963f\u6614\u66ff\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a1mg\u30015mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e00\u79cd\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u6216\u7ec6\u80de\u56e0\u5b50\u6cbb\u7597\u5931\u8d25\u7684\u8fdb\u5c55\u671f\u80be\u7ec6\u80de\u764c\uff08<\/span>RCC\uff09\u7684\u6210\u4eba\u60a3\u8005\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u963f\u6614\u66ff\u5c3c\u63a8\u8350\u7684\u8d77\u59cb\u53e3\u670d\u5242\u91cf\u4e3a5mg\uff0c\u6bcf\u65e5\u4e24\u6b21\uff0c\u53ef\u4e0e\u98df\u7269\u540c\u670d\u6216\u7a7a\u8179\u7ed9\u836f\uff0c\u6bcf\u65e5\u4e24\u6b21\u7ed9\u836f\u7684\u65f6\u95f4\u95f4\u9694\u7ea6\u4e3a12\u5c0f\u65f6\u3002\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5c31\u5e94\u7ee7\u7eed\u6cbb\u7597\u76f4\u81f3\u53d1\u751f\u4e0d\u80fd\u63a5\u53d7\u7684\u6bd2\u6027\u3002\u5982\u679c\u60a3\u8005\u5455\u5410\u6216\u6f0f\u670d\u4e00\u6b21\u5242\u91cf\uff0c\u4e0d\u5e94\u53e6\u5916\u670d\u7528\u4e00\u6b21\u5242\u91cf\uff0c\u5e94\u6309\u5e38\u89c4\u670d\u7528\u4e0b\u4e00\u6b21\u5242\u91cf\u3002<\/span><\/p>\n

2.\u5efa\u8bae\u6839\u636e\u60a3\u8005\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7684\u4e2a\u4f53\u5dee\u5f02\u589e\u52a0\u6216\u964d\u4f4e\u5242\u91cf\uff1a\uff081\uff09\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0c\u6ee1\u8db3\u4e0b\u8ff0\u6807\u51c6\u7684\u60a3\u8005\u53ef\u589e\u52a0\u5242\u91cf\uff1a\u80fd\u8010\u53d7\u963f\u6614\u66ff\u5c3c\u81f3\u5c11\u4e24\u5468\u8fde\u7eed\u6cbb\u7597\u3001\u672a\u51fa\u73b02\u7ea7\u4ee5\u4e0a\u4e0d\u826f\u53cd\u5e94\u3001\u8840\u538b\u6b63\u5e38\u3001\u672a\u63a5\u53d7\u964d\u538b\u836f\u7269\u6cbb\u7597\u3002\u5f53\u63a8\u8350\u4ece5mg\uff0c\u6bcf\u65e5\u4e24\u6b21\u5f00\u59cb\u589e\u52a0\u5242\u91cf\u65f6\uff0c\u53ef\u5c06\u963f\u6614\u66ff\u5c3c\u5242\u91cf\u589e\u52a0\u81f37mg\uff0c\u6bcf\u65e5\u4e24\u6b21\uff0c\u7136\u540e\u91c7\u7528\u76f8\u540c\u6807\u51c6\uff0c\u8fdb\u4e00\u6b65\u5c06\u5242\u91cf\u589e\u52a0\u81f310mg\uff0c\u6bcf\u65e5\u4e24\u6b21\u3002\uff082\uff09\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u6216\u6c38\u4e45\u7ec8\u6b62\u7ed9\u836f\uff0c\u6216\u964d\u4f4e\u963f\u6614\u66ff\u5c3c\u5242\u91cf\u3002\u5982\u679c\u9700\u8981\u4ece5mg\uff0c\u6bcf\u65e5\u4e24\u6b21\u5f00\u59cb\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u4e3a3mg\uff0c\u6bcf\u65e5\u4e24\u6b21\u3002\u5982\u679c\u9700\u8981\u518d\u6b21\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u4e3a2mg\uff0c\u6bcf\u65e5\u4e24\u6b21\u3002<\/span><\/p>\n

3.\u907f\u514d\u4e0e\u5f3a\u6548CYP3A4\/5\u6291\u5236\u5242\uff08\u5982\u916e\u5eb7\u5511\u3001\u4f0a\u66f2\u5eb7\u5511\u3001\u514b\u62c9\u9709\u7d20\u7b49\uff09\u6216\u5f3a\u6548CYP3A4\/5\u8bf1\u5bfc\u5242\uff08\u5982\u5229\u798f\u5e73\u3001\u5730\u585e\u7c73\u677e\u7b49\uff09\u5408\u7528\u3002<\/span><\/p>\n

\u4e94\u3001\u57f9\u5511\u5e15\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u57f9\u5511\u5e15\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a200mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u672c\u54c1\u9002\u7528\u4e8e\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u548c\u66fe\u63a5\u53d7\u7ec6\u80de\u56e0\u5b50\u6cbb\u7597\u7684\u665a\u671fRCC\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u57f9\u5511\u5e15\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a800mg\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u7a7a\u8179\u670d\u836f\u3002\u5982\u679c\u6f0f\u670d\u5242\u91cf\uff0c\u4e14\u8ddd\u4e0b\u6b21\u5242\u91cf\u7684\u670d\u7528\u65f6\u95f4\u4e0d\u8db312\u5c0f\u65f6\uff0c\u5219\u4e0d\u5e94\u8865\u670d\u3002<\/span><\/p>\n

2.\u5242\u91cf\u8c03\u6574\u5e94\u6839\u636e\u4e2a\u4f53\u8010\u53d7\u60c5\u51b5\uff0c\u6309200mg\u7684\u5e45\u5ea6\u9010\u6b65\u9012\u589e\u6216\u9012\u51cf\uff0c\u4ee5\u63a7\u5236\u4e0d\u826f\u53cd\u5e94\u3002\u57f9\u5511\u5e15\u5c3c\u7684\u5242\u91cf\u4e0d\u5e94\u8d85\u8fc7800mg\u3002<\/span><\/p>\n

3.\u5728\u57f9\u5511\u5e15\u5c3c\u4f7f\u7528\u671f\u95f4\uff0c\u8f7b\u5ea6\u6216\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u5bb3\u60a3\u8005\u5e94\u614e\u7528\u57f9\u5511\u5e15\u5c3c\uff0c\u5e76\u4e14\u5e94\u5bc6\u5207\u76d1\u6d4b\uff0c\u5bf9\u4e8e\u57fa\u7ebf\u603b\u80c6\u7ea2\u7d20\u7684\u6570\u503c\u22641.5\u500dULN\uff0c\u4e14AST\u53caALT\u7684\u6570\u503c\u22642\u500dULN\u7684\u60a3\u8005\uff0c\u5176\u5242\u91cf\u8c03\u6574\u53c2\u89c1\u9488\u5bf9\u836f\u7269\u6027\u809d\u6bd2\u6027\u7684\u5242\u91cf\u8c03\u6574\u6307\u5357\u3002<\/span><\/p>\n

4.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u809d\u529f\u80fd\u635f\u5bb3\u548c\u9ad8\u8840\u538b\u3002<\/span><\/p>\n

5.\u907f\u514d\u540c\u65f6\u4f7f\u7528CYP3A4\u3001P-\u7cd6\u86cb\u767d\uff08P-gp\uff09\u6216\u4e73\u817a\u764c\u8010\u836f\u86cb\u767d\uff08BCRP\uff09\u7684\u5f3a\u6291\u5236\u5242\u6cbb\u7597\u3002<\/span><\/p>\n


<\/p>\n

\u4e73\u817a\u764c\u7528\u836f<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u4e00\u3001\u66f2\u59a5\u73e0\u5355\u6297<\/span><\/strong><\/p>\n

\u901a\u7528\u540d<\/span><\/strong>\uff1a<\/span><\/strong>\u6ce8\u5c04\u7528\u66f2\u59a5\u73e0\u5355\u6297<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u9488\u5242\uff1a440mg\uff0820ml\uff09\/\u74f6<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u590d\u53d1\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff1a\u672c\u54c1\u9002\u7528\u4e8eHER2\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff0c\u5355\u836f\u7528\u4e8e\u5df2\u63a5\u53d7\u8fc7\u591a\u4e2a\u5316\u7597\u65b9\u6848\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff1b\u4e0e\u7d2b\u6749\u9187\u6216\u591a\u897f\u4ed6\u8d5b\u7b49\u5316\u7597\u836f\u7269\u8054\u5408\uff0c\u7528\u4e8e\u672a\u63a5\u53d7\u5316\u7597\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002<\/span><\/p>\n

2.\u4e73\u817a\u764c\u8f85\u52a9\u6cbb\u7597\uff1a\u672c\u54c1\u5355\u836f\u9002\u7528\u4e8e\u80bf\u5757\uff1e0.5cm\u6216\u4f34\u814b\u4e0b\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u540e\u7684HER2\u9633\u6027\u4e73\u817a\u764c\u7684\u8f85\u52a9\u6cbb\u7597\u3002\u6216\u4e0e\u7d2b\u6749\u7c7b\u53ca\u5176\u4ed6\uff08\u73af\u78f7\u9170\u80fa\u3001\u5361\u94c2\u7b49\uff09\u5316\u7597\u836f\u7269\u5408\u7528\uff0c\u8fd8\u53ef\u4e0e\u653e\u7597\u3001\u8f85\u52a9\u5185\u5206\u6ccc\u6cbb\u7597\u540c\u65f6\u4f7f\u7528\u3002<\/span><\/p>\n

3.\u4e73\u817a\u764c\u65b0\u8f85\u52a9\u6cbb\u7597\uff1aHER2\u9633\u6027\u4e73\u817a\u764c\u65b0\u8f85\u52a9\u6cbb\u7597\u5e94\u542b\u66f2\u59a5\u73e0\u5355\u6297\u7684\u65b9\u6848\uff0c\u672f\u540e\u7ee7\u7eed\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u603b\u7597\u7a0b\u4e3a1\u5e74\u3002<\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u5728\u63a5\u53d7\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u524d\uff0c\u5e94\u5728\u6709\u8d44\u8d28\u7684\u75c5\u7406\u5b9e\u9a8c\u5ba4\u8fdb\u884cHER2\u68c0\u6d4b\uff0cHER2\u9633\u6027\u60a3\u8005\u65b9\u53ef\u5e94\u7528\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\uff0cHER2\u9633\u6027\u7684\u5b9a\u4e49\u4e3aIHC3+\u6216FISH\u9633\u6027\u3002<\/span><\/p>\n

2.\u4e0e\u84bd\u73af\u7c7b\u836f\u7269\u540c\u671f\u5e94\u7528\u987b\u614e\u91cd\uff0c\u53ef\u80fd\u589e\u52a0\u5fc3\u808c\u635f\u5bb3\uff0c\u4e25\u91cd\u8005\u4f1a\u53d1\u751f\u5fc3\u529b\u8870\u7aed\uff0c\u5e94\u5e8f\u8d2f\u4f7f\u7528\u6216\u5206\u522b\u4f7f\u7528\u3002<\/span><\/p>\n

3.\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u8981\u5bf9\u65e2\u5f80\u53f2\u3001\u4f53\u683c\u68c0\u67e5\u3001\u5fc3\u7535\u56fe\u3001\u8d85\u58f0\u5fc3\u52a8\u56feLVEF\u57fa\u7ebf\u8bc4\u4f30\u540e\uff0c\u518d\u5f00\u59cb\u5e94\u7528\u66f2\u59a5\u73e0\u5355\u6297\uff0c\u4f7f\u7528\u671f\u95f4\u5e94\u6bcf3\u4e2a\u6708\u76d1\u6d4bLVEF\u3002\u82e5\u60a3\u8005\u6709\u65e0\u75c7\u72b6\u6027\u5fc3\u529f\u80fd\u4e0d\u5168\uff0c\u76d1\u6d4b\u9891\u7387\u5e94\u66f4\u9ad8\u3002\u51fa\u73b0\u4e0b\u5217\u60c5\u51b5\u65f6\uff1a\uff081\uff09LVEF\u8f83\u6cbb\u7597\u524d\u7edd\u5bf9\u503c\u4e0b\u964d\u5927\u4e8e\u7b49\u4e8e15%\uff1b\uff082\uff09LVEF\u4f4e\u4e8e\u6b63\u5e38\u8303\u56f4\u5e76\u4e14\u8f83\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u4e0b\u964d\u5927\u4e8e\u7b49\u4e8e10%\uff0c\u5e94\u6682\u505c\u6cbb\u7597\uff0c\u5e76\u8ddf\u8e2a\u76d1\u6d4bLVEF\u7ed3\u679c\uff0c\u59824\uff5e8\u5468\u5185\u82e5LVEF\u56de\u5347\u81f3\u6b63\u5e38\u6216LVEF\u8f83\u6cbb\u7597\u524d\u7edd\u5bf9\u503c\u5c0f\u4e8e\u7b49\u4e8e10%\uff0c\u53ef\u6062\u590d\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u3002LVEF\u6301\u7eed\u4e0b\u964d\uff08\u5927\u4e8e8\u5468\uff09\uff0c\u6216\u80053\u6b21\u4ee5\u4e0a\u56e0\u5fc3\u808c\u75c5\u800c\u505c\u6b62\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u5e94\u6c38\u4e45\u505c\u7528\u66f2\u59a5\u73e0\u5355\u6297\u3002<\/span><\/p>\n

4.\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u8bc1\u5b9e\uff0cHER2\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5728\u5176\u4ed6\u5316\u7597\u836f\u7269\u6216\u5185\u5206\u6ccc\u836f\u7269\u6cbb\u7597\u65f6\uff0c\u8054\u5408\u66f2\u59a5\u73e0\u5355\u6297\u53ef\u8fdb\u4e00\u6b65\u589e\u52a0\u4e34\u5e8a\u83b7\u76ca\u3002<\/span><\/p>\n

5.\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u540e\u8fdb\u5c55\u7684HER2\u9633\u6027\u4e73\u817a\u764c\uff0c\u4e5f\u6709\u8bc1\u636e\u8bc1\u5b9e\u7ee7\u7eed\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u7684\u4e34\u5e8a\u83b7\u76ca\u3002<\/span><\/p>\n

\u4e8c\u3001\u7532\u82ef\u78fa\u9178\u62c9\u5e15\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u7532\u82ef\u78fa\u9178\u62c9\u5e15\u66ff\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a0.25g<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u7532\u82ef\u78fa\u9178\u62c9\u5e15\u66ff\u5c3c\u4e0e\u5361\u57f9\u4ed6\u6ee8\u8054\u7528\uff0c\u9002\u7528\u4e8eHER2\u8fc7\u8868\u8fbe\u4e14\u65e2\u5f80\u63a5\u53d7\u8fc7\u5305\u62ec\u84bd\u73af\u7c7b\u3001\u7d2b\u6749\u7c7b\u548c\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u7684\u665a\u671f\u6216\u8005\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u8003\u8651\u4f7f\u7528\u672c\u836f\u7684\u60a3\u8005\u9700\u8fdb\u884c\u7ec4\u7ec7\u6807\u672c\uff08\u539f\u53d1\u7076\u6216\u8f6c\u79fb\u7076\uff09\u7684HER2\u68c0\u6d4b\uff0c\u65e0\u8bba\u662f\u539f\u53d1\u7076\u8fd8\u662f\u8f6c\u79fb\u7076\uff0c\u9700HER2\u514d\u75ab\u7ec4\u53163+\u6216FISH\u9633\u6027\u3002<\/span><\/p>\n

2.\u4ec5\u9002\u7528\u4e8e\u590d\u53d1\u8f6c\u79fb\u60a3\u8005\uff0c\u539f\u5219\u4e0a\u4e0d\u63a8\u8350\u4e00\u7ebf\u4f7f\u7528\uff0c\u9664\u975e\u662f\u60a3\u8005\u6709\u66f2\u59a5\u73e0\u5355\u6297\u7684\u7981\u5fcc\u8bc1\u6216\u53c2\u52a0\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n

3. \u672c\u54c1\u5355\u72ec\u4f7f\u7528\u65f6\u6bcf\u6b211.25g\uff085\u7247\uff09\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u7b2c1\uff5e21\u5929\u8fde\u7eed\u670d\u7528\u3002\u4e0e\u5361\u57f9\u4ed6\u6ee8\u8054\u7528\u65f6\uff0c\u7532\u82ef\u78fa\u9178\u62c9\u5e15\u66ff\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u540c\u4e0a\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u6bcf21\u59291\u4e2a\u5468\u671f\uff0c\u5efa\u8bae\u5c06\u6bcf\u65e5\u5242\u91cf\u4e00\u6b21\u6027\u670d\u7528\uff0c\u4e0d\u63a8\u8350\u5206\u6b21\u670d\u7528\u3002\u5e94\u5728\u9910\u524d\u81f3\u5c111\u5c0f\u65f6\uff0c\u6216\u9910\u540e\u81f3\u5c111\u5c0f\u65f6\u670d\u7528\u3002\u5361\u57f9\u4ed6\u6ee8\u63a8\u8350\u5242\u91cf\u4e3a2g\/\uff08m2<\/sup><\/span>\u25aa<\/span>d\uff09\uff0c\u52062\u6b21\u53e3\u670d\u3002\u95f4\u9694\u7ea612\u5c0f\u65f6\uff0c\u8fde\u670d14\u5929\uff0c\u4f11\u606f7\u5929\uff0c21\u5929\u4e3a\u4e00\u4e2a\u5468\u671f\u3002\u5361\u57f9\u4ed6\u6ee8\u5e94\u548c\u98df\u7269\u540c\u65f6\u670d\u7528\uff0c\u6216\u9910\u540e30\u5206\u949f\u5185\u670d\u7528\u3002<\/span><\/span><\/p>\n

4.\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u4e3a\u8179\u6cfb\u548c\u76ae\u75b9\uff0c\u8179\u6cfb\u53ef\u5bf9\u75c7\u6b62\u6cfb\uff0c\u7528\u836f\u671f\u95f4\u907f\u514d\u76f4\u63a5\u65e5\u6652\uff0c\u5916\u51fa\u6ce8\u610f\u9632\u6652\u3002\u4f7f\u7528\u672c\u54c1\u53ef\u53d1\u751f\u5fc3\u810f\u6bd2\u6027\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u5de6\u5ba4\u5c04\u8840\u5206\u6570\uff08LVEF\uff09\u51cf\u4f4e\uff0c\u82e5LVEF\u4e0b\u964d\u81f3\u6b63\u5e38\u503c\u4e0b\u9650\uff0c\u6216\u51fa\u73b02\u7ea7\u62162\u7ea7\u4ee5\u4e0a\u4e0eLVEF\u4e0b\u964d\u76f8\u5173\u7684\u75c7\u72b6\uff0c\u5e94\u505c\u836f\u3002\u82e5\u6062\u590d\u81f3\u6b63\u5e38\uff0c\u4e14\u60a3\u8005\u65e0\u75c7\u72b6\uff0c\u53ef\u4ee5\u5728\u505c\u7528\u81f3\u5c112\u5468\u540e\u5c06\u672c\u54c1\u51cf\u91cf\u4f7f\u7528\uff08\u6bcf\u59291g\u4e0e\u5361\u57f9\u4ed6\u6ee8\u8054\u7528\uff09\u3002\u90e8\u5206\u75c5\u4eba\u8fd8\u53ef\u51fa\u73b0\u809d\u635f\u5bb3\u3002<\/span><\/p>\n

5.\u5982\u679c\u60a3\u8005\u6f0f\u670d\u4e86\u67d0\u4e00\u5929\u7684\u5242\u91cf\uff0c\u7b2c\u4e8c\u5929\u7684\u5242\u91cf\u4e0d\u8981\u52a0\u500d\uff0c\u5728\u4e0b\u4e00\u6b21\u670d\u836f\u65f6\u95f4\u6309\u8ba1\u5212\u7ee7\u7eed\u670d\u7528\u5373\u53ef\u3002\u6cbb\u7597\u5e94\u5f53\u6301\u7eed\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u80fd\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002<\/span><\/p>\n

6.\u672c\u54c1\u4e3b\u8981\u7ecfCYP3A4\u4ee3\u8c22\u3002\u670d\u836f\u671f\u95f4\u7981\u98df\u8461\u8404\u67da\u3001\u8461\u8404\u67da\u679c\u6c41\uff0c\u4e0e\u5df2\u77e5CYP3A4\u6291\u5236\u5242\u7ed9\u836f\u65f6\u9700\u8c28\u614e\uff0c\u5fc5\u987b\u5408\u7528\u65f6\uff0c\u6839\u636e\u836f\u52a8\u5b66\u7814\u7a76\uff0c\u672c\u54c1\u5242\u91cf\u51cf\u81f3\u6bcf\u59290.5g\u53ef\u5c06\u672c\u54c1AUC\u8c03\u6574\u81f3\u65e0\u6291\u5236\u5242\u65f6\u7684\u8303\u56f4\uff0c\u4f46\u76ee\u524d\u7f3a\u4e4f\u4e34\u5e8a\u6570\u636e\u652f\u6301\u3002\u4e0eCYP3A4\u8bf1\u5bfc\u5242\u5408\u7528\u65f6\u5e94\u8c28\u614e\uff0c\u5fc5\u987b\u5408\u7528\u65f6\uff0c\u6839\u636e\u836f\u52a8\u5b66\u3001\u8010\u53d7\u6027\uff0c\u53ef\u5c06\u672c\u54c1\u4ece\u6bcf\u59291.25g\u9010\u6b65\u589e\u52a0\u81f3\u6bcf\u59294.5g\uff0c\u4f46\u76ee\u524d\u7f3a\u4e4f\u4e34\u5e8a\u6570\u636e\u652f\u6301\u3002\u4e0e\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u7ed3\u5408\u7528\u65f6\u4e5f\u5e94\u8c28\u614e\u3002<\/span><\/p>\n

7.\u7532\u82ef\u78fa\u9178\u62c9\u5e15\u66ff\u5c3c\u53ef\u964d\u4f4eLVEF\u3002\u5efa\u8bae\u6cbb\u7597\u524d\u8bc4\u4f30LVEF\uff0c\u6cbb\u7597\u4e2d\u5b9a\u671f\u68c0\u6d4bLVEF\u3002LVEF\u51cf\u5c11\u2161\u5ea6\u4ee5\u4e0a\u548cLVEF\u964d\u4f4e\u5230\u6b63\u5e38\u4e0b\u9650\u4ee5\u4e0b\uff0c\u60a3\u8005\u5e94\u4e2d\u65ad\u7532\u82ef\u78fa\u9178\u62c9\u5e15\u66ff\u5c3c\u6cbb\u7597\u3002\u6700\u5c11\u4e24\u5468\u540e\uff0c\u5982LVEF\u6062\u590d\u5230\u6b63\u5e38\u548c\u60a3\u8005\u65e0\u75c7\u72b6\uff0c\u7532\u82ef\u78fa\u9178\u62c9\u5e15\u66ff\u5c3c\u53ef\u51cf\u5c11\u5242\u91cf\uff08\u6bcf\u59291g\uff09\u91cd\u65b0\u5f00\u59cb\u3002<\/span><\/p>\n

8.\u4e5f\u6709\u4e34\u5e8a\u7814\u7a76\u8bc1\u660e\uff0c\u7532\u82ef\u78fa\u9178\u62c9\u5e15\u66ff\u5c3c\u8054\u5408\u5176\u4ed6\u5316\u7597\u836f\u7269\u6216\u5185\u5206\u6ccc\u6cbb\u7597\u836f\u7269\u53ef\u4f7f\u75c5\u4eba\u4e34\u5e8a\u83b7\u76ca\u3002<\/span><\/p>\n


<\/p>\n

\u76ae\u80a4\u53ca\u8f6f\u7ec4\u7ec7\u80bf\u7624\u7528\u836f<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u4e00\u3001\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u7247\uff0c\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u80f6\u56ca<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\uff081\uff09\u7247\u5242\uff1a400mg\u3001100mg\uff1b\uff082\uff09\u80f6\u56ca\uff1a100mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u5bf9\u4e0d\u80fd\u5207\u9664\u548c\/\u6216\u8f6c\u79fb\u6027KIT\u7a81\u53d8\u7684\u6076\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u524d\u5fc5\u987b\u7ecf\u7531\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u786e\u5b9a\u80bf\u7624\u4e3aC-KIT\u7a81\u53d8\u9633\u6027\uff0c\u624d\u53ef\u4f7f\u7528\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\uff0c\u514d\u75ab\u7ec4\u5316CD117\u9633\u6027\u4e0d\u80fd\u66ff\u4ee3KIT\u7a81\u53d8\u57fa\u56e0\u68c0\u6d4b\uff0c\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u4e0d\u80fd\u7528\u4e8eKIT\u91ce\u751f\u578b\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<\/span><\/p>\n

2.\u5bf9\u4e8eKIT\u7a81\u53d8\u7684\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u63a8\u8350\u5242\u91cf\u4e3a400mg\uff1b400mg\u6cbb\u7597\u8fdb\u5c55\u540e\u53ef\u9075\u533b\u5631\u589e\u91cf\u81f3600mg\u3001800mg\uff0c\u4ecd\u6709\u90e8\u5206\u60a3\u8005\u83b7\u76ca\uff0c\u4f46\u4e0d\u826f\u53cd\u5e94\u4ea6\u52a0\u91cd\u3002<\/span><\/p>\n

3.\u7528\u836f\u671f\u95f4\u5e38\u89c1\u7684\u53cd\u5e94\u5305\u62ec\u6c34\u80bf\u3001\u4e4f\u529b\u3001\u98df\u6b32\u51cf\u9000\u3001\u76ae\u75b9\u3001\u7c92\u7ec6\u80de\u4e0b\u964d\u7b49\uff0c\u670d\u836f\u671f\u95f4\u5e94\u5b9a\u671f\u68c0\u6d4b\u8840\u5e38\u89c4\u3001\u809d\u80be\u529f\u80fd\u3002<\/span><\/p>\n

4.\u4e0d\u80fd\u541e\u54bd\u836f\u7247\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u5c06\u836f\u7247\u5206\u6563\u4e8e\u4e0d\u542b\u6c14\u4f53\u7684\u6c34\u4e2d\uff08100mg\u7247\u7ea6\u752850ml\uff0c400mg\u7ea6\u7528200ml\uff09\u3002\u5e94\u6405\u62cc\u6df7\u60ac\u6db2\uff0c\u4e00\u65e6\u836f\u7247\u5d29\u89e3\u5b8c\u5168\u5e94\u7acb\u5373\u670d\u7528\u3002<\/span><\/p>\n

5.\u548cCYP3A4\u8bf1\u5bfc\u5242\u540c\u65f6\u670d\u7528\u53ef\u663e\u8457\u964d\u4f4e\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u7684\u603b\u66b4\u9732\u91cf\uff0c\u56e0\u6b64\u589e\u52a0\u6f5c\u5728\u6cbb\u7597\u5931\u8d25\u7684\u5371\u9669\u3002\u56e0\u6b64\u5e94\u907f\u514d\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u4e0eCYP3A4\u8bf1\u5bfc\u5242\u6216\u6291\u5236\u5242\u5408\u7528\u3002\u5e38\u89c1\u7684CYP3A4\u8bf1\u5bfc\u5242\u6216\u6291\u5236\u5242\u5305\u62ec\u916e\u5eb7\u5511\u3001\u73af\u5b62\u7d20\u3001\u5339\u83ab\u9f50\u7279\u3001\u534e\u6cd5\u6797\u4ee5\u53ca\u5176\u4ed6\u9999\u8c46\u7d20\u884d\u751f\u7269\u3002<\/span><\/p>\n

\u4e8c\u3001<\/span>\u7ef4\u83ab\u975e\u5c3c<\/span><\/span><\/strong><\/p>\n

\u901a\u7528\u540d<\/span><\/strong>\uff1a<\/span><\/strong>\u7ef4\u83ab\u975e\u5c3c\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/strong>\uff1a<\/span><\/strong>\u7247\u5242\uff1a240mg<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u786e\u5b9a\u7684BRAFV600\u7a81\u53d8\u9633\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u7528\u836f\u524d\u5fc5\u987b\u7ecf\u7531\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u786e\u5b9a\u80bf\u7624\u4e3aBRAFV600\u7a81\u53d8\u9633\u6027\uff0c\u624d\u53ef\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\u6cbb\u7597\uff0c\u7ef4\u83ab\u975e\u5c3c\u4e0d\u80fd\u7528\u4e8eBRAF\u91ce\u751f\u578b\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<\/em><\/span><\/p>\n

2.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u53cd\u5e94\u5982\u76ae\u75b9\uff0c\u5149\u654f\u53cd\u5e94\u7b49\u3002<\/em><\/span><\/p>\n

3.\u57fa\u7ebf\u65f6QTc\uff1e500ms\u4e0d\u5efa\u8bae\u5f00\u59cb\u670d\u7528\u7ef4\u83ab\u975e\u5c3c\uff0c\u5bf9\u4e8e\u5b58\u5728\u65e0\u6cd5\u7ea0\u6b63\u7684\u7535\u89e3\u8d28\u5f02\u5e38\u3001\u957fQT\u7efc\u5408\u5f81\u6216\u6b63\u5728\u670d\u7528\u5df2\u77e5\u80fd\u5ef6\u957fQT\u95f4\u671f\u7684\u836f\u7269\u7684\u60a3\u8005\uff0c\u4e0d\u5efa\u8bae\u91c7\u7528\u7ef4\u83ab\u975e\u5c3c\u6cbb\u7597\u3002<\/em><\/span><\/p>\n

4.\u4e0d\u5efa\u8baeIpilimumab\u4e0e\u7ef4\u83ab\u975e\u5c3c\u8054\u5408\u7528\u836f\u3002<\/em><\/span><\/p>\n

5.\u598a\u5a20\u671f\u5987\u5973\u7981\u6b62\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\uff0c\u9664\u975e\u5bf9\u4e8e\u6bcd\u4eb2\u7684\u53ef\u80fd\u53d7\u76ca\u8d85\u8fc7\u5bf9\u80ce\u513f\u7684\u53ef\u80fd\u98ce\u9669\u3002\u5fc5\u987b\u5728\u6743\u8861\u54fa\u4e73\u5582\u517b\u5bf9\u5a74\u513f\u7684\u76ca\u5904\u4ee5\u53ca\u6cbb\u7597\u5bf9\u6bcd\u4eb2\u7684\u76ca\u5904\u4e4b\u540e\uff0c\u505a\u51fa\u662f\u5426\u505c\u6b62\u6bcd\u4e73\u5582\u517b\u6216\u505c\u6b62\u7ef4\u83ab\u975e\u5c3c\u6cbb\u7597\u7684\u51b3\u5b9a\u3002<\/em><\/span><\/p>\n

6.\u4e0d\u5efa\u8bae\u7ef4\u83ab\u975e\u5c3c\u4e0e\u7ecfCYP1A2\u548cCYP3A4\u4ee3\u8c22\u7684\u6cbb\u7597\u7a97\u8f83\u7a84\u7684\u836f\u7269\u8054\u5408\u5e94\u7528\uff0c\u5728\u4e0e\u7ef4\u83ab\u975e\u5c3c\u8054\u5408\u7528\u836f\u7684\u60c5\u51b5\u4e0b\uff0c\u5e94\u614e\u7528\u5f3a\u6548CYP3A4\u6291\u5236\u5242\u5982\u916e\u5eb7\u5511\u548c\u8bf1\u5bfc\u5242\u5982\u82ef\u59a5\u82f1\u3002<\/span><\/p>\n

\u4e09\u3001\u4f9d\u7ef4\u83ab\u53f8<\/span><\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u4f9d\u7ef4\u83ab\u53f8\u7247<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u7247\u5242\uff1a2.5mg\u30015mg\uff0c10mg\uff08\u4e2d\u56fd\u65e0\u672c\u89c4\u683c\uff09<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u9700\u8981\u6cbb\u7597\u5e72\u9884\u4f46\u4e0d\u9002\u4e8e\u624b\u672f\u5207\u9664\u7684\u7ed3\u8282\u6027\u786c\u5316\u75c7\uff08TSC\uff09\u76f8\u5173\u7684\u5ba4\u7ba1\u819c\u4e0b\u5de8\u7ec6\u80de\u661f\u5f62\u7ec6\u80de\u7624\uff08SEGA\uff09\u6210\u4eba\u548c\u513f\u7ae5\u60a3\u8005\u3002<\/span><\/p>\n

2.\u7528\u4e8e\u6cbb\u7597\u4e0d\u9700\u7acb\u5373\u624b\u672f\u6cbb\u7597\u7684\u7ed3\u8282\u6027\u786c\u5316\u75c7\u76f8\u5173\u7684\u80be\u8840\u7ba1\u5e73\u6ed1\u808c\u8102\u80aa\u7624\uff08TSC-RAML\uff09\u6210\u4eba\u60a3\u8005\u3002<\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u809d\u529f\u80fd\u53d7\u635f\u4f1a\u4f7f\u4f9d\u7ef4\u83ab\u53f8\u66b4\u9732\u91cf\u589e\u52a0\uff0c\u6309\u5982\u4e0b\u65b9\u5f0f\u8fdb\u884c\u7ed9\u836f\u8c03\u6574\uff1a\uff081\uff09\u8f7b\u5ea6\u809d\u529f\u80fd\u53d7\u635f\uff08Child-Pugh A\u7ea7\uff09\uff1a\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u59297.5mg\uff1b\u5982\u679c\u4e0d\u80fd\u5f88\u597d\u5730\u8010\u53d7\uff0c\u53ef\u5c06\u5242\u91cf\u964d\u81f3\u6bcf\u59295mg\u3002\uff082\uff09\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u635f\uff08Child-Pugh B\u7ea7\uff09\uff1a\u63a8\u8350\u5242\u91cf\u662f\u6bcf\u59295mg\uff1b\u5982\u679c\u4e0d\u80fd\u5f88\u597d\u5730\u8010\u53d7\uff0c\u53ef\u5c06\u5242\u91cf\u964d\u81f3\u6bcf\u59292.5mg\u3002\uff083\uff09\u91cd\u5ea6\u809d\u529f\u80fd\u53d7\u635f\uff08Child-Pugh C\u7ea7\uff09\uff1a\u5982\u679c\u9884\u671f\u7684\u83b7\u76ca\u9ad8\u4e8e\u98ce\u9669\uff0c\u53ef\u4ee5\u91c7\u7528\u6bcf\u59292.5mg\uff0c\u4f46\u4e0d\u5f97\u8d85\u8fc7\u8fd9\u4e00\u5242\u91cf\u3002<\/span><\/p>\n

2.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u53e3\u8154\u708e\u7b49\uff1b\u5e94\u7279\u522b\u6ce8\u610f\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\uff0c\u53ef\u80fd\u4f1a\u53d1\u751f\u808c\u9150\u3001\u8840\u7cd6\u548c\u8840\u8102\u5f02\u5e38\uff0c\u6ce8\u610f\u7528\u836f\u671f\u95f4\u590d\u67e5\u3002<\/span><\/p>\n

3.\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5f3a\u6548CYP3A4\u8bf1\u5bfc\u5242\uff08\u5982\u82ef\u59a5\u82f1\u3001\u5361\u9a6c\u897f\u5e73\u3001\u5229\u798f\u5e73\u3001\u5229\u798f\u5e03\u4e01\u3001\u5229\u798f\u55b7\u6c40\u548c\u82ef\u5df4\u6bd4\u59a5\uff09\uff0c\u786e\u9700\u4e0eCYP3A4\u5f3a\u8bf1\u5bfc\u5242\u5408\u7528\uff0c\u9700\u589e\u52a0\u5242\u91cf\uff0c\u6700\u5927\u5242\u91cf\u6bcf\u592920mg\u3002<\/span><\/p>\n

4.\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u5e94\u907f\u514d\u63a5\u79cd\u6d3b\u75ab\u82d7\uff0c\u907f\u514d\u4e0e\u63a5\u79cd\u8fc7\u6d3b\u75ab\u82d7\u7684\u4eba\u5bc6\u5207\u63a5\u89e6\u3002<\/span><\/p>\n

5\uff0e\u5982\u9700\u4f7f\u7528CYP3A4\u4e2d\u5ea6\u6291\u5236\u5242\u6216P-\u7cd6\u86cb\u767d\u6291\u5236\u5242\uff0c\u51cf\u91cf\u81f3\u6bcf\u59292.5mg\uff0c\u5982\u679c\u8010\u53d7\u53ef\u589e\u52a0\u81f3\u5242\u91cf\u6bcf\u59295mg\u3002<\/span><\/p>\n

6\uff0e\u598a\u5a20\u5987\u5973\u670d\u7528\u65f6\u53ef\u80fd\u5bf9\u80ce\u513f\u4ea7\u751f\u5371\u5bb3\uff0c\u5e94\u5145\u5206\u544a\u77e5\u3002<\/span><\/p>\n


<\/p>\n

\u5934\u9888\u90e8\u80bf\u7624\u7528\u836f<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u4e00\u3001\u5c3c\u59a5\u73e0\u5355\u6297<\/span><\/strong> <\/span><\/p>\n

\u901a\u7528\u540d\uff1a<\/span><\/strong>\u5c3c\u59a5\u73e0\u5355\u6297\u6ce8\u5c04\u6db2<\/span><\/span><\/p>\n

\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/strong>\u9488\u5242\uff1a50mg\uff0810ml\uff09\/\u74f6<\/span><\/span><\/p>\n

\u9002\u5e94\u8bc1\uff1a<\/span><\/strong>\u4e0e\u653e\u7597\u8054\u5408\u6cbb\u7597EGFR\u57fa\u56e0\u9633\u6027\u8868\u8fbe\u7684\u2162\uff5e\u2163\u671f\u9f3b\u54bd\u764c\u3002<\/span><\/span><\/p>\n

\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1.\u5c3c\u59a5\u73e0\u5355\u6297\u51bb\u878d\u540e\u6297\u4f53\u5927\u90e8\u5206\u6d3b\u6027\u5c06\u4e27\u5931\uff0c\u6545\u5728\u50a8\u5b58\u8fc7\u7a0b\u4e2d\u4e25\u7981\u51b7\u51bb\u3002<\/span><\/p>\n

2.\u5c3c\u59a5\u73e0\u5355\u6297\u914d\u5236\u7684\u6eb6\u6db2\u5728\u8f93\u6db2\u5bb9\u5668\u4e2d2\uff5e8\u2103\u65f6\uff0c\u5176\u7269\u7406\u548c\u5316\u5b66\u7a33\u5b9a\u6027\u53ef\u4fdd\u630112\u5c0f\u65f6\uff0c\u5728\u5ba4\u6e29\u4e0b\u53ef\u4fdd\u63018\u5c0f\u65f6\u3002\u50a8\u5b58\u65f6\u95f4\u8d85\u8fc7\u4e0a\u8ff0\u65f6\u95f4\uff0c\u4e0d\u5b9c\u7ee7\u7eed\u4f7f\u7528\u3002<\/span><\/p>\n

3.\u5c3c\u59a5\u73e0\u5355\u6297\u4e0e\u653e\u7597\u8054\u5408\u9002\u7528\u4e8e\u6cbb\u7597EGFR\u57fa\u56e0\u9633\u6027\u8868\u8fbe\u7684\u2162\uff5e\u2163\u671f\u9f3b\u54bd\u764c\u3002<\/span><\/p>\n

4.\u4f7f\u7528\u5c3c\u59a5\u73e0\u5355\u6297\u524d\uff0c\u5efa\u8bae\u5148\u786e\u8ba4\u80bf\u7624\u7ec4\u7ec7\u7684EGFR\u57fa\u56e0\u8868\u8fbe\u6c34\u5e73\uff0c\u9488\u5bf9EGFR\u57fa\u56e0\u4e2d\u3001\u9ad8\u8868\u8fbe\u7684\u60a3\u8005\u63a8\u8350\u4f7f\u7528\u672c\u54c1\u3002<\/span><\/p>\n

5.\u514d\u75ab\u7ec4\u5316\u6cd5\u68c0\u9a8cEGFR\u57fa\u56e0\u8868\u8fbe\uff0c\u64cd\u4f5c\u5e94\u7531\u719f\u7ec3\u638c\u63e1EGFR\u57fa\u56e0\u68c0\u6d4b\u8bd5\u5242\u76d2\u68c0\u6d4b\u6280\u672f\u7684\u5b9e\u9a8c\u5ba4\u5b8c\u6210\u3002\u68c0\u9a8c\u4e2d\u7684\u67d0\u4e9b\u5931\u8bef\uff0c\u5982\u7ec4\u7ec7\u6837\u672c\u8d28\u91cf\u8f83\u5dee\u3001\u64cd\u4f5c\u4e0d\u89c4\u8303\u3001\u5bf9\u7167\u4f7f\u7528\u4e0d\u5f53\u7b49\u5747\u53ef\u5f71\u54cd\u7ed3\u679c\u3002<\/span><\/p>\n

6.\u6cbb\u7597\u671f\u95f4\u56e0\u6bd2\u6027\u4e0d\u53ef\u8010\u53d7\u65f6\u53ef\u5728\u540c\u4e00\u4ee3\u836f\u7269\u4e4b\u95f4\u66ff\u6362\uff0c\u56e0\u75be\u75c5\u8fdb\u5c55\u4e0d\u80fd\u5728\u540c\u4e00\u4ee3\u836f\u7269\u4e4b\u95f4\u66ff\u6362\u3002<\/span><\/p>\n

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8.\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u53cd\u5e94\u548c\u8179\u6cfb\u3002<\/span><\/p>\n

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\u4e8c\u3001\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c <\/span><\/strong><\/span><\/p>\n

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2.\u5b58\u5728\u53ef\u7591\u7684\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u548c\/\u6216\u51cf\u5c11\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u5242\u91cf\u3002<\/span><\/p>\n

3.\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u6709\u8179\u6cfb\uff0c\u4e4f\u529b\uff0c\u8131\u53d1\uff0c\u611f\u67d3\uff0c\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\uff0c\u76ae\u75b9\u3002<\/span><\/p>\n

4.\u5bf9\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u6216\u672c\u54c1\u4efb\u4e00\u975e\u6d3b\u6027\u6210\u5206\u6709\u4e25\u91cd\u8fc7\u654f\u75c7\u72b6\u7684\u60a3\u8005\u7981\u7528\u3002<\/span><\/p>\n

5.\u4e0eUGT1A1\u9014\u5f84\u4ee3\u8c22\/\u6e05\u9664\u7684\u836f\u7269\u8054\u5408\u5e94\u7528\u65f6\uff0c\u9700\u8c28\u614e\uff1b\u4e0e\u591a\u897f\u4ed6\u8d5b\u8054\u5408\u5e94\u7528\u65f6\uff0c\u9700\u8c28\u614e\uff1b\u4e0eCYP3A4\u8bf1\u5bfc\u5242\u8054\u5408\u5e94\u7528\u65f6\u53ef\u5bfc\u81f4\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u7684\u836f\u7269\u6d53\u5ea6\u964d\u4f4e\uff1b\u4e0e\u65b0\u9709\u7d20\u8054\u5408\u5e94\u7528\u53ef\u5bfc\u81f4\u7532\u82ef\u78fa\u9178\u7d22\u62c9\u975e\u5c3c\u7684\u66b4\u9732\u91cf\u4e0b\u964d\u3002<\/span><\/p>\n

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\"\u3010\u91cd\u8981\u3011\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\"<\/section>\n<\/section>\n<\/section>\n
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\"\u3010\u91cd\u8981\u3011\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\"<\/section>\n<\/section>\n
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\u5ef6\u4f38\u9605\u8bfb<\/span><\/strong><\/section>\n
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\u6297\u4f53\u836f\u7814\u53d1\u73b0\u72b6\u53ca\u7acb\u9879\u89e3\u6790<\/strong><\/span><\/a><\/p>\n


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\u6297\u4f53\u836f\u53d1\u73b0\u53ca\u5e8f\u5217\u4f18\u5316<\/a><\/strong><\/span><\/p>\n


<\/p>\n

\u6297\u4f53\u836f\u751f\u4ea7\u548c\u5de5\u827a\u8d28\u63a7<\/span><\/a><\/p>\n


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QA\u4e13\u5458\u6280\u80fd\u5b8c\u5584\u3001\u63d0\u5347\u4e0e\u5b9e\u64cd\u4e13\u9898\u57f9\u8bad<\/span><\/a><\/p>\n


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\"\u3010\u91cd\u8981\u3011\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\"<\/p>\n<\/section>\n<\/section>\n

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\u4e25\u6b63\u58f0\u660e<\/strong>
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\u672c\u6587\u8f6c\u8f7d\u4e8e\u533b\u5e06\u98ce\u987a\uff0c<\/span>\u65e8\u5728\u77e5\u8bc6\u5171\u4eab\uff0c\u65e0\u4efb\u4f55\u5546\u4e1a\u7528\u9014\uff0c\u5982\u6d89\u53ca\u4fb5\u6743\u8bf7\u53ca\u65f6\u8054\u7cfb\u5c0f\u7f16<\/span>tinorl@163.com<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\"\u3010\u91cd\u8981\u3011\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\"<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\n<\/section>\n<\/section>\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u5173\u4e8e\u5370\u53d1\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\u7684\u901a\u77e5  \u56fd\u536b\u529e\u533b\u51fd\u30142018\u3015821\u53f7&nb […]<\/p>\n","protected":false},"author":1,"featured_media":50473,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/50472"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=50472"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/50472\/revisions"}],"predecessor-version":[{"id":50483,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/50472\/revisions\/50483"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/50473"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=50472"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=50472"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=50472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}