{"id":50824,"date":"2018-09-22T01:00:00","date_gmt":"2018-09-26T02:13:03","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/pd-1%e5%b7%b2%e7%bb%8f%e5%bc%80%e5%94%ae%ef%bc%8c%e4%bd%86%e6%9c%89%e7%a7%8d%e9%ba%bb%e7%83%a6%e4%b8%80%e5%ae%9a%e8%a6%81%e5%b0%bd%e5%8a%9b%e9%81%bf%e5%bc%80%ef%bc%81\/"},"modified":"2018-09-26T10:13:06","modified_gmt":"2018-09-26T02:13:06","slug":"pd-1%e5%b7%b2%e7%bb%8f%e5%bc%80%e5%94%ae%ef%bc%8c%e4%bd%86%e6%9c%89%e7%a7%8d%e9%ba%bb%e7%83%a6%e4%b8%80%e5%ae%9a%e8%a6%81%e5%b0%bd%e5%8a%9b%e9%81%bf%e5%bc%80%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/50824\/","title":{"rendered":"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"xmteditor\" style=\"display:none;\"  ><\/section>\n<section style=\"font-size: 15px;line-height: 2;letter-spacing: 0.5px;padding: 0px 20px;color: rgb(99, 99, 110);box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;border-width: 0px;border-radius: 5px;border-style: none;border-color: rgb(99, 99, 110);overflow: hidden;box-sizing: border-box;\"><img class=\"\"          style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;width: 518px;height: 206px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1537927984.jpeg\" alt=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\" title=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"font-size: 13px;color: rgb(132, 132, 141);box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\">\u6587\u4e28\u764c\u5ea6\u533b\u5b66\u90e8<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u81ea\u201c\u795e\u836fPD-1\u201d\u7b2c\u4e00\u6b21\u51fa\u73b0\u5728\u4eba\u4eec\u7684\u89c6\u91ce\u4e2d\uff0c\u5c31\u4e00\u76f4\u95ea\u8000\u7740\u660e\u661f\u822c\u7684\u5149\u8292\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u57fa\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4f18\u79c0\u6570\u636e\uff0c\u5df2\u6709\u4e24\u6b3ePD-1\u7c7b\u836f\u7269<span style=\"color: rgb(132, 132, 141);box-sizing: border-box;\">\uff08O\u836f\u548cK\u836f\uff09<\/span>\u767b\u9646\u4e2d\u56fd\u5e02\u573a\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u56e0\u5177\u6709\u957f\u671f\u7684\u751f\u5b58\u671f\u4f18\u52bf\u548c\u8f83\u5c11\u7684\u526f\u4f5c\u7528\uff0cPD-1\u5728\u8fd1\u51e0\u5e74\u7684\u80bf\u7624\u6cbb\u7597\u9886\u57df\u51fa\u5c3d\u4e86\u98ce\u5934\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u795e\u836f\u90a3\u4e48\u795e\u5947\uff0c\u662f\u4e0d\u662f\u7528\u4e86PD-1\u5c31\u53ef\u4ee5\u9ad8\u6795\u65e0\u5fe7\u4e86\uff1f<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u60c5\u51b5\u5e76\u975e\u5982\u6b64\uff0c\u5e76\u975e\u6bcf\u4e00\u4e2a\u6709\u9002\u5e94\u75c7\u7684\u60a3\u8005\u4f7f\u7528PD-1\u90fd\u6709\u6548\uff0c\u8fd9\u70b9\u6bd4\u8f83\u597d\u7406\u89e3\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u4f46\u5947\u602a\u7684\u662f\uff0c\u6709\u7684\u60a3\u8005\u7528\u4e86PD-1\u80bf\u7624\u4e0d\u4ec5\u6ca1\u7f29\u5c0f\uff0c\u53cd\u800c\u5feb\u901f\u589e\u5927\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u8fd9\u91cc\u6709\u4e24\u79cd\u60c5\u51b5\uff0c<strong style=\"box-sizing: border-box;\">\u4e00\u79cd\u662f\u5047\u6027\u8fdb\u5c55<\/strong>\uff0c\u8fd9\u90e8\u5206\u75c5\u4eba\u9700\u8981\u7ee7\u7eed\u4f7f\u7528PD-1\uff0c\u7ecf\u8fc7\u4e00\u6bb5\u65f6\u95f4\u4e4b\u540e\uff0c\u75c5\u7076\u5c31\u4f1a\u663e\u8457\u7f29\u5c0f\uff0c\u75c5\u4eba\u53ef\u4ee5\u8fbe\u5230\u4e00\u4e2a\u957f\u671f\u7684\u83b7\u76ca\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u4f46\u662f<strong style=\"box-sizing: border-box;\">\u8fd8\u6709\u4e00\u79cd\u60c5\u51b5\u662f\u771f\u7684\u8fdb\u5c55<\/strong>\uff0c\u800c\u4e14\u662f\u75c5\u60c5\u8d85\u7ea7\u8fdb\u5c55\u3002\u5728\u77ed\u671f\u65f6\u95f4\u5185\uff0c\u80bf\u7624\u8fc5\u901f\u589e\u5927<span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8d85\u8fc7\u4e86\u6cbb\u7597\u524d\u768450%<\/strong><\/span>\uff0c\u4f60\u8bf4\u53ef\u6015\u4e0d\u53ef\u6015\uff01<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537927984.jpg\" alt=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\" title=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u8fd8\u597d\u51fa\u73b0\u7206\u53d1\u8fdb\u5c55\u7684\u665a\u671f\u764c\u75c7\u60a3\u8005\u6bd4\u4f8b\u4e0d\u9ad8\uff0c\u4e0d\u523010%\u7684\u6bd4\u4f8b\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5373\u4f7f\u6982\u7387\u6bd4\u8f83\u5c0f\uff0c\u80fd\u5426\u5728\u514d\u75ab\u6cbb\u7597\u524d\u63d0\u524d\u9884\u6d4b\u51fa\u60a3\u8005\u51fa\u73b0\u7206\u53d1\u8fdb\u5c55\u7684\u53ef\u80fd\u6027\u5462\uff1f<\/strong><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u6700\u65b0\u53d1\u8868\u5728\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\u300b\u4e0a\u7684\u4e00\u7bc7\u6587\u7ae0\uff0c\u8bb2\u8ff0\u4e86\u4e00\u4e2a\u5173\u4e8e\u7206\u53d1\u8fdb\u5c55\u7684\u7814\u7a76\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u7814\u7a76\u7684\u76ee\u7684\u662f\u63a2\u8ba8\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<span style=\"color: rgb(132, 132, 141);box-sizing: border-box;\">\uff08NSCLC\uff09<\/span>\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6cbb\u7597\u671f\u95f4\uff0c\u7206\u53d1\u8fdb\u5c55\u662f\u5426\u53ef\u4ee5\u9884\u6d4b\uff0c\u4ee5\u53ca\u7206\u53d1\u8fdb\u5c55\u662f\u5426\u662fPD-1\u7684\u7279\u5f02\u6027\u8fdb\u5c55\u6a21\u5f0f\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u80bf\u7624\u751f\u957f\u7387<span style=\"color: rgb(132, 132, 141);box-sizing: border-box;\">\uff08TGR\uff09<\/span>\u53ef\u4ee5\u8bc4\u4ef7\u80bf\u7624\u4f53\u79ef\u751f\u957f\u7684\u5feb\u6162\uff0c\u52a8\u6001\u53cd\u5e94\u6cbb\u7597\u524d\u540e\u80bf\u7624\u4f53\u79ef\u5927\u5c0f\u7684\u53d8\u5316\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u7814\u7a76\u4eba\u5458\u5728\u4e00\u7ec4\u8ba1\u5212\u514d\u75ab\u6cbb\u7597\u7684\u665a\u671fNSCLC\u60a3\u8005\u4e2d\u6bd4\u8f83\u4e86PD-1\u6cbb\u7597\u524d\u548c\u6cbb\u7597\u671f\u95f4\u7684\u80bf\u7624\u751f\u957f\u7387\uff0c\u5e76\u5c06\u5355\u836f\u5316\u7597\u7684\u60a3\u8005\u4f5c\u4e3a\u5bf9\u7167\u7ec4\uff0c\u6765\u6bd4\u8f83\u4e24\u7ec4\u4e4b\u95f4TGR\u548c\u7206\u53d1\u8fdb\u5c55\u60a3\u75c5\u7387\u7684\u5dee\u5f02\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u5728\u63a5\u53d7PD-1\u6cbb\u7597\u7684406\u540d\u60a3\u8005\u4e2d\uff0c46.3\uff05<span style=\"color: rgb(132, 132, 141);box-sizing: border-box;\">\uff08n = 188\uff09<\/span>\u4e3a65\u5c81\u6216\u4ee5\u4e0a\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a12.1\u4e2a\u6708\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f<span style=\"color: rgb(132, 132, 141);box-sizing: border-box;\">\uff08OS\uff09<\/span>\u4e3a13.4\u4e2a\u6708\u3002\u6700\u540e\u670956\u540d\u60a3<span style=\"color: rgb(132, 132, 141);box-sizing: border-box;\">\uff0813.8\uff05\uff09<\/span>\u88ab\u5f52\u7c7b\u4e3a\u7206\u53d1\u8fdb\u5c55\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u57284.7\uff05<span style=\"color: rgb(132, 132, 141);box-sizing: border-box;\">\uff08n = 19\uff09<\/span>\u7684\u7fa4\u4f53\u4e2d\u89c2\u5bdf\u5230\u5047\u6027\u8fdb\u5c55\u3002\u4e0e\u975e\u7206\u53d1\u8fdb\u5c55\u76f8\u6bd4\uff0c\u7206\u53d1\u8fdb\u5c55\u7684\u75c5\u4eba\u7279\u70b9\u5f80\u5f80\u662f\u4f7f\u7528PD-1\u4e4b\u524d\u5b58\u5728\u8d85\u8fc72\u4e2a\u4ee5\u4e0a\u7684\u8f6c\u79fb\u7076\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u5728PD-1\u6cbb\u7597\u7684\u524d6\u5468\u5185\u51fa\u73b0\u7206\u53d1\u8fdb\u5c55\u7684\u60a3\u8005\u4e0e\u666e\u901a\u8fdb\u5c55\u60a3\u8005\u76f8\u6bd4\uff0cOS\u663e\u8457\u964d\u4f4e<span style=\"color: rgb(132, 132, 141);box-sizing: border-box;\">\uff083.4\u4e2a\u6708vs6.2\u4e2a\u6708\uff09<\/span>\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u572859\u540d\u7b26\u5408\u6761\u4ef6\u7684\u5316\u7597\u60a3\u8005\u4e2d\uff0c<strong style=\"box-sizing: border-box;\">3\u540d\uff085.1\uff05\uff09\u88ab\u5f52\u7c7b\u4e3a\u7206\u53d1\u8fdb\u5c55\u3002<\/strong><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537927985.jpg\" alt=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\" title=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u672c\u7814\u7a76\u662f\u8fc4\u4eca\u4e3a\u6b62\u63a2\u7d22\u7206\u53d1\u8fdb\u5c55\u7684\u6700\u5927\u5206\u6790\uff0c\u4e5f\u662f\u9996\u6b21\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4eba\u7fa4\u4e2d\u8fdb\u884c\u7684\u7814\u7a76\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u4ece\u672c\u7814\u7a76\u7684\u6570\u636e\u6765\u770b\uff0c<strong style=\"box-sizing: border-box;\">PD-1\u7ec4\u4e0e\u5316\u7597\u7ec4\u53d1\u751f\u7206\u53d1\u8fdb\u5c55\u7684\u6bd4\u4f8b\u5206\u522b\u662f13.8\uff05\u548c5.1\uff05\u3002\u800c\u4e14\u5728\u6cbb\u7597\u524d\u6709\u591a\u4e2a\u8f6c\u79fb\u7076\u7684\u60a3\u8005\u4f7f\u7528PD-1\u51fa\u73b0\u7206\u53d1\u8fdb\u5c55\u7684\u6982\u7387\u66f4\u5927\u4e00\u4e9b\u3002<\/strong><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u9274\u4e8e\u76ee\u524d\u7206\u53d1\u8fdb\u5c55\u7684\u53d1\u751f\u673a\u5236\u8fd8\u6ca1\u6709\u786e\u5207\u7684\u7ed3\u8bba\uff0c\u5df2\u7ecf\u51fa\u73b0\u7206\u53d1\u8fdb\u5c55\u60a3\u8005\u8f83\u5dee\u7684\u751f\u5b58\u6570\u636e\uff0c\u65e9\u671f\u5224\u65ad\u51fa\u7206\u53d1\u8fdb\u5c55\u7684\u60a3\u8005\u5c24\u4e3a\u91cd\u8981\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u4ee5\u5f80\u6709\u7814\u7a76\u8868\u660e\uff0c<strong style=\"box-sizing: border-box;\">\u5927\u4e8e65\u7684\u9ad8\u9f84\u60a3\u8005<\/strong>\u4e8e\u7206\u53d1\u8fdb\u5c55\u6709\u5173\u3002\u9664\u6b64\u4e4b\u5916\uff0c<strong style=\"box-sizing: border-box;\">MDM2\u57fa\u56e0\u6269\u589e\u548cEGFR\u7a81\u53d8<\/strong>\u4e5f\u53ef\u80fd\u662f\u7206\u53d1\u8fdb\u5c55\u7684\u9884\u6d4b\u56e0\u7d20\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1537927985.jpg\" alt=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\" title=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u7531\u4e8e\u51fa\u73b0\u7206\u53d1\u8fdb\u5c55\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\u8f83\u5dee\uff0c\u5bf9\u4e8e\u6cbb\u7597\u524d\u6709\u591a\u4e2a\u8f6c\u79fb\u7076\u7684\u60a3\u8005\uff0c\u6216\u8005\u5b58\u5728\u7206\u53d1\u8fdb\u5c55\u53d1\u751f\u56e0\u7d20\u7684\u4e34\u5e8a\u7c7b\u578b\uff0c\u5e94\u5728\u4f7f\u7528\u514d\u75ab\u6cbb\u7597\u7684\u8fc7\u7a0b\u4e2d\u4e25\u683c\u68c0\u6d4b\u75c5\u60c5\u53d8\u5316\uff0c\u82e5\u51fa\u73b0\u7206\u53d1\u8fdb\u5c55\u7684\u82d7\u5934\u65f6\uff0c\u53ca\u65f6\u8f6c\u53d8\u6cbb\u7597\u6a21\u5f0f\uff0c\u53ef\u80fd\u662f\u4e00\u4e2a\u660e\u667a\u7684\u9009\u62e9\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u672c\u7814\u7a76\u7684\u4e3b\u9898\u662f\u4e00\u4e2a\u6709\u4e89\u8bae\u6027\u7684\u95ee\u9898\uff0c\u533b\u5b66\u754c\u8fd8\u6ca1\u6709\u8fbe\u6210\u7edf\u4e00\u7684\u5171\u8bc6\u3002<\/strong><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u5982\u679c\u60a8\u6709\u4ec0\u4e48\u95ee\u9898\u6216\u89c1\u89e3\uff0c\u6b22\u8fce\u5728\u4e0b\u65b9\u7559\u8a00\u4ee5\u4fbf\u5927\u5bb6\u8fdb\u884c\u8ba8\u8bba\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"font-size: 12px;color: rgb(132, 132, 141);box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u6587\u732e\u6765\u6e90\uff1a<\/strong><\/p>\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\">Roberto Ferrara\uff0cet al.,Hyperprogressive Disease in Patients With Advanced Non\u2013Small Cell Lung Cancer Treated With PD-1\/PD-L1 Inhibitors or With Single-Agent Chemotherapy, doi:10.1001\/jamaoncol.2018.3676<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;width: 60%;box-sizing: border-box;\"><img     style=\"vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537927985.png\" alt=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\" title=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\"><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 0px 0% 10px;box-sizing: border-box;\">\n<section style=\"font-size: 14px;letter-spacing: 5px;color: rgb(70, 87, 114);box-sizing: border-box;\">\n<p style=\"text-align: center;margin: 0px;padding: 0px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u764c\u5ea6\u670d\u52a1\u9879\u76ee<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" ><a title=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247492477&amp;idx=3&amp;sn=8a001cef076560de3fe7351b5eb970f1&amp;scene=21#wechat_redirect\" formlinkparm=\"&quot;https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247492477&amp;idx=3&amp;sn=8a001cef076560de3fe7351b5eb970f1&amp;scene=21#wechat_redirect&quot;\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247492477&amp;idx=3&amp;sn=8a001cef076560de3fe7351b5eb970f1&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"box-sizing: border-box;\"><\/p>\n<section style=\"text-align: center;margin: 10px 0% 20px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;border-width: 2px;border-radius: 5px;border-style: groove;border-color: rgb(250, 250, 250);box-shadow: rgb(250, 250, 250) 0px 0px 0px;width: 90%;overflow: hidden;box-sizing: border-box;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;margin: 0px;right: auto;bottom: auto;\"><img     style=\"vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;margin: 0px;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1537927985.jpeg\" alt=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\" title=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\"><\/span><\/section>\n<\/section>\n<p><\/a><\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" ><a title=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491621&amp;idx=3&amp;sn=585b4d9ba8c293fd7a9f67bb3cba1b04&amp;scene=21#wechat_redirect\" formlinkparm=\"&quot;https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491621&amp;idx=3&amp;sn=585b4d9ba8c293fd7a9f67bb3cba1b04&amp;scene=21#wechat_redirect&quot;\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491621&amp;idx=3&amp;sn=585b4d9ba8c293fd7a9f67bb3cba1b04&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"box-sizing: border-box;\"><\/p>\n<section style=\"text-align: center;margin: 10px 0% 20px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;border-width: 2px;border-radius: 5px;border-style: groove;border-color: rgb(250, 250, 250);box-shadow: rgb(0, 0, 0) 0px 0px 0px;width: 90%;overflow: hidden;box-sizing: border-box;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;margin: 0px;right: auto;bottom: auto;\"><img     style=\"vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;margin: 0px;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1537927985.jpeg\" alt=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\" title=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\"><\/span><\/section>\n<\/section>\n<p><\/a><\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" ><a title=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491621&amp;idx=2&amp;sn=f81112744650511081c757f7845c5802&amp;scene=21#wechat_redirect\" formlinkparm=\"&quot;https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491621&amp;idx=2&amp;sn=f81112744650511081c757f7845c5802&amp;scene=21#wechat_redirect&quot;\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491621&amp;idx=2&amp;sn=f81112744650511081c757f7845c5802&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"box-sizing: border-box;\"><\/p>\n<section style=\"text-align: center;margin: 10px 0% 20px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;border-width: 2px;border-radius: 5px;border-style: groove;border-color: rgb(250, 250, 250);box-shadow: rgb(0, 0, 0) 0px 0px 0px;width: 90%;overflow: hidden;box-sizing: border-box;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;margin: 0px;right: auto;bottom: auto;\"><img     style=\"vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;margin: 0px;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537927986.jpeg\" alt=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\" title=\"PD-1\u5df2\u7ecf\u5f00\u552e\uff0c\u4f46\u6709\u79cd\u9ebb\u70e6\u4e00\u5b9a\u8981\u5c3d\u529b\u907f\u5f00\uff01\"><\/span><\/section>\n<\/section>\n<p><\/a><\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" ><a title=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247492477&amp;idx=2&amp;sn=d12ce7450e7a9c8f24bf7c1bf43a13f9&amp;scene=21#wechat_redirect\" formlinkparm=\"&quot;https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247492477&amp;idx=2&amp;sn=d12ce7450e7a9c8f24bf7c1bf43a13f9&amp;scene=21#wechat_redirect&quot;\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247492477&amp;idx=2&amp;sn=d12ce7450e7a9c8f24bf7c1bf43a13f9&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"box-sizing: border-box;\"><\/p>\n<section style=\"text-align: center;margin: 10px 0% 20px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;border-width: 2px;border-radius: 5px;border-style: groove;border-color: rgb(250, 250, 250);box-shadow: rgb(0, 0, 0) 0px 0px 0px;width: 90%;overflow: hidden;box-sizing: border-box;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;margin: 0px;right: auto;bottom: auto;\"><\/span><\/section>\n<\/section>\n<p><\/a><\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6587\u4e28\u764c\u5ea6\u533b\u5b66\u90e8 \u81ea\u201c\u795e\u836fPD-1\u201d\u7b2c\u4e00\u6b21\u51fa\u73b0\u5728\u4eba\u4eec\u7684\u89c6\u91ce\u4e2d\uff0c\u5c31\u4e00\u76f4\u95ea\u8000\u7740\u660e\u661f\u822c\u7684\u5149\u8292\u3002 \u57fa\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4f18\u79c0\u6570\u636e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":50825,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/50824"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=50824"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/50824\/revisions"}],"predecessor-version":[{"id":50834,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/50824\/revisions\/50834"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/50825"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=50824"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=50824"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=50824"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}