{"id":51432,"date":"2018-09-19T01:00:00","date_gmt":"2018-09-26T02:18:38","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/car-t%e6%b2%bb%e7%96%97%e6%96%b0%e6%96%b9%e5%90%91%ef%bc%9a%e8%87%aa%e8%ba%ab%e5%85%8d%e7%96%ab%e7%97%85%e4%b8%8e%e7%a7%bb%e6%a4%8d%e7%89%a9%e6%8a%97%e5%ae%bf%e4%b8%bb%e7%97%85\/"},"modified":"2018-09-26T10:18:39","modified_gmt":"2018-09-26T02:18:39","slug":"car-t%e6%b2%bb%e7%96%97%e6%96%b0%e6%96%b9%e5%90%91%ef%bc%9a%e8%87%aa%e8%ba%ab%e5%85%8d%e7%96%ab%e7%97%85%e4%b8%8e%e7%a7%bb%e6%a4%8d%e7%89%a9%e6%8a%97%e5%ae%bf%e4%b8%bb%e7%97%85","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/51432\/","title":{"rendered":"CAR-T\u6cbb\u7597\u65b0\u65b9\u5411\uff1a\u81ea\u8eab\u514d\u75ab\u75c5\u4e0e\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5"},"content":{"rendered":"
\n

\u5bf9\u4e8e\u67d0\u4e9bB\u7ec6\u80de\u76f8\u5173\u7684\u8840\u6db2\u764c\u75c7\u6765\u8bf4\uff0cCAR-T\u7597\u6cd5\u7684\u7597\u6548\u6bcb\u5eb8\u7f6e\u7591\u3002\u53bb\u5e74<\/span>FDA<\/span>\u6279\u51c6\u4e86\u4e24\u6b3eCAR-T\u7597\u6cd5\u4e0a\u5e02\uff0c\u8bb8\u591a\u5236\u836f\u516c\u53f8\u5728\u5f00\u59cb\u5728\u8be5\u9886\u57df\u6295\u5165\u5927\u91cf\u7684\u8d44\u91d1\u548c\u4eba\u529b\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4f46CAR-T\u7597\u6cd5\u7684\u4e34\u5e8a\u5e94\u7528\u4f9d\u7136\u9762\u4e34\u7740\u8bb8\u591a\u7684\u969c\u788d\uff0c\u6bd4\u5982\u6bd2\u6027\u53cd\u5e94\u63a7\u5236\uff0c\u5b9e\u4f53\u7624\u6709\u6548\u7387\u4f4e\uff0c\u8fd9\u4e9b\u90fd\u662f\u4e9f\u9700\u89e3\u51b3\u7684\u95ee\u9898\u3002\u800c\u4e14\u5982\u4f55\u5f00\u53d1\u901a\u7528\u578bCAR-T\u4e5f\u662f\u76ee\u524d\u8be5\u9886\u57df\u7684\u79d1\u7814\u4eba\u5458\u6b63\u5728\u52aa\u529b\u7684\u65b9\u5411\u3002<\/span><\/p>\n


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\u4f46\u4e0e\u6b64\u540c\u65f6\uff0c\u4e5f\u6709\u4e00\u5c0f\u90e8\u5206\u79d1\u5b66\u5bb6\u4e5f\u5728\u5c1d\u8bd5\u56de\u7b54\u53e6\u4e00\u4e2a\u95ee\u9898\uff1a<\/span>\u9664\u4e86\u764c\u75c7\uff0cCAR-T\u7597\u6cd5\u80fd\u5426\u5e94\u7528\u4e8e\u5176\u4ed6\u75be\u75c5\u6cbb\u7597\u9886\u57df\uff1f<\/span><\/p>\n


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\u5f88\u591a\u79d1\u5b66\u5bb6\u76f8\u4fe1\u8fd9\u4e2a\u95ee\u9898\u7684\u7b54\u6848\u662f\u80af\u5b9a\u7684\u3002\u9664\u4e86\u764c\u75c7\uff0cCAR-T\u7597\u6cd5\u4e5f\u540c\u6837\u6709\u53ef\u80fd\u88ab\u5e94\u7528\u4e8e\u75c5\u6bd2\u611f\u67d3\u3001<\/span>\u81ea\u8eab\u514d\u75ab<\/span>\u75c5\u4ee5\u53ca<\/span>\u5668\u5b98\u79fb\u690d<\/span>\u5f15\u8d77\u7684\u6392\u5f02\u53cd\u5e94\u7b49\u75be\u75c5\u9886\u57df\u7684\u6cbb\u7597\uff0c\u800c\u8fd9\u4e5f\u6709\u53ef\u80fd\u5f00\u542fCAR-T\u7597\u6cd5\u7684\u65b0\u7684\u65b9\u5411\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5728\u6cbb\u7597\u764c\u75c7\u7684CAR-T\u76f8\u5173\u7597\u6cd5\u4e2d\uff0c\u533b\u751f\u9996\u5148\u63d0\u53d6\u75c5\u4eba\u7684T\u7ec6\u80de\uff0c\u8fd9\u4e9b\u7ec6\u80de\u5728\u7ecf\u8fc7\u6539\u9020\u5e76\u8868\u8fbe\u7279\u5b9a\u5d4c\u5408\u6297\u539f\u53d7\u4f53\u4e4b\u540e\u4f1a\u88ab\u56de\u8f93\u5230\u8be5\u75c5\u4eba\u7684\u4f53\u5185\uff0c\u4ece\u800c\u8bc6\u522b\u5e76\u6740\u706d<\/span>\u80bf\u7624<\/span>\u7ec6\u80de\u3002\u9700\u8981\u6ce8\u610f\u7684\u662f\u76ee\u524d\u53d6\u5f97\u6210\u529f\u7684\u75be\u75c5\u9886\u57df\u5747\u4e3aB\u7ec6\u80de\u76f8\u5173\u7684\u764c\u75c7\u3002<\/span><\/p>\n


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\u7136\u800cB\u7ec6\u80de\u5728\u8bb8\u591a<\/span>\u81ea\u8eab\u514d\u75ab<\/span>\u75c5\u7684\u75c5\u7406\u8fc7\u7a0b\u4e2d\u540c\u6837\u626e\u6f14\u7740\u91cd\u8981\u4f5c\u7528\u3002B\u7ec6\u80de\u5206\u6ccc\u7684\u67d0\u4e9b\u79cd\u7c7b\u7684\u6297\u4f53\u6709\u53ef\u80fd\u4f1a\u7ed3\u5408\u5065\u5eb7\u7684\u7ec4\u7ec7\u7ec6\u80de\uff0c\u4ece\u800c\u4f7f\u8fd9\u4e9b\u5065\u5eb7\u7684\u7ec6\u80de\u906d\u53d7\u514d\u75ab\u7ec6\u80de\u7684\u653b\u51fb\uff0c\u4ece\u800c\u5f15\u53d1<\/span>\u81ea\u8eab\u514d\u75ab<\/span>\u75c5\u3002<\/span><\/p>\n


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\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8fd9\u4e9b\u514d\u75ab\u75be\u75c5\u8fd8\u6ca1\u6709\u6cbb\u6108\u7684\u53ef\u80fd\uff0c\u75c5\u4eba\u901a\u5e38\u53ef\u4ee5\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u7684\u6cbb\u7597\uff0c\u4f46\u8fd9\u4e9b\u836f\u7269\u6709\u53ef\u80fd\u4f1a\u63d0\u9ad8\u60a3\u8005\u611f\u67d3\u4ee5\u53ca\u764c\u75c7\u7684\u98ce\u9669\u3002<\/span><\/p>\n


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\u56e0\u6b64\u4e00\u4e9b\u79d1\u7814\u4eba\u5458\u4e5f\u5728\u5c1d\u8bd5\u4f7f\u7528CAR-T\u7597\u6cd5\u6765\u6cbb\u7597\u8fd9\u7c7b\u75be\u75c5\u3002\u4f46\u4e0e\u6cbb\u7597\u764c\u75c7\u7684CAR-T\u7597\u6cd5\u4e0d\u540c\u7684\u662f\uff0c\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u75c5\u7684CAR-T\u7597\u6cd5\u5e76\u4e0d\u9700\u8981\u6e05\u9664\u75c5\u4eba\u4f53\u5185\u7684\u6240\u6709B\u7ec6\u80de\uff0c\u800c\u53ea\u8981\u6e05\u9664\u80fd\u591f\u4ea7\u751f\u5f15\u53d1\u81ea\u8eab\u514d\u75ab\u75c5\u6297\u4f53\u7684B\u7ec6\u80de\u5c31\u53ef\u4ee5\u4e86\uff1a\u901a\u8fc7\u4f7fT\u7ec6\u80de\u8868\u8fbe\u7279\u5b9a\u7684CAAR (chimeric autoantibody receptors)\uff0c\u4f7f\u8fd9\u4e9b\u7ec6\u80de\u80fd\u591f\u8bc6\u522b\u7279\u5b9a\u7684\u81ea\u8eab\u514d\u75ab\u6027B\u7ec6\u80de\uff0c\u4ece\u800c\u5c06\u5176\u6740\u706d\u5df2\u8fbe\u5230\u6cbb\u7597\u8be5\u7c7b\u75be\u75c5\u7684\u76ee\u7684\u3002<\/span><\/p>\n


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\u4f46\u5373\u4f7f\u662f\u8fd9\u7c7b\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u75c5\u7684CAR-T\u7597\u6cd5\uff0c\u4f7f\u7528\u7684\u4ecd\u7136\u662f\u6740\u4f24\u7c7b\u7684T\u7ec6\u80de\u3002\u800c\u8fd9\u7c7bT\u7ec6\u80de\u5176\u5b9e\u53ea\u662fT\u7ec6\u80de\u5927\u519b\u4e2d\u7684\u4e00\u5458\u3002\u76ee\u524d\u5f88\u591a\u79d1\u7814\u5de5\u4f5c\u8005\u4e5f\u5728\u7814\u7a76\u5982\u4f55\u4f7f\u7528\u53e6\u4e00\u7c7bT\u7ec6\u80de\uff1aTreg\u7ec6\u80de\uff0c\u5e76\u5c06\u5176\u5e94\u7528\u4e8eCAR-T\u7597\u6cd5\u3002<\/span><\/p>\n


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Treg\u7ec6\u80de\u80fd\u591f\u6291\u5236\u514d\u75ab\u7cfb\u7edf\u7684\u8fc7\u6fc0\u53cd\u5e94\uff0c\u8fd9\u7c7b\u7ec6\u80de\u7684\u5b58\u5728\u4e5f\u7b97\u662f\u673a\u4f53\u7684\u4e00\u79cd\u81ea\u6211\u4fdd\u62a4\u673a\u5236\uff0c\u907f\u514d\u4f53\u5185\u7684\u514d\u75ab\u53cd\u5e94\u5931\u53bb\u63a7\u5236\u800c\u5bf9\u81ea\u8eab\u673a\u4f53\u4ea7\u751f\u4f24\u5bb3\u3002\u5f88\u591a\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u5176\u5b9e\u4e5f\u662f\u56e0\u4e3aTreg\u7ec6\u80de\u65e0\u6cd5\u6b63\u5e38\u53d1\u6325\u4f5c\u7528\u800c\u5bfc\u81f4\u7684\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"CAR-T\u6cbb\u7597\u65b0\u65b9\u5411\uff1a\u81ea\u8eab\u514d\u75ab\u75c5\u4e0e\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\"
<\/p>\n

CAR-expressing regulatory T cell therapy<\/span><\/p>\n


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\u57282016\u5e74\u7684\u65f6\u5019\uff0c\u52a0\u62ff\u5927\u7684\u4e00\u4e2a\u7814\u7a76\u56e2\u961f\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u8868\u8fbe\u5d4c\u5408\u6297\u539f\u53d7\u4f53\u7684Treg\u7ec6\u80de\u80fd\u591f\u6291\u5236<\/span>\u5668\u5b98\u79fb\u690d<\/span>\u5f15\u8d77\u7684\u514d\u75ab\u6392\u65a5\u53cd\u5e94\u3002\u8fd9\u9879\u7814\u7a76\u8bc1\u5b9e\u4e86CAR-Treg\u8fd9\u79cd\u6cbb\u7597\u7b56\u7565\u7684\u53ef\u884c\u6027\u3002<\/span><\/p>\n


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\u524d\u4e0d\u4e45\uff0c\u4e00\u4e9bCAR-Treg\u76f8\u5173\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u663e\u793a\u8be5\u7c7b\u7597\u6cd5\u7684\u5b89\u5168\u6027\u826f\u597d\uff0c\u800c\u4e14\u4e5f\u663e\u793a\u8fd9\u7c7b\u7597\u6cd5\u80fd\u591f\u5ef6\u8fdfI\u578b<\/span>\u7cd6\u5c3f\u75c5<\/span>\u7684\u8fdb\u5c55\u4ee5\u53ca\u63a7\u5236\u9aa8\u9ad3\u79fb\u690d\u4e4b\u540e\u7684\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u3002<\/span><\/p>\n


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\u56fd\u5185\u7684CAR-T\u7597\u6cd5\u540c\u8d28\u5316\u4e25\u91cd\uff0c\u5982\u4f55\u8fdb\u884c\u5dee\u5f02\u5316\u7814\u7a76\u5c06\u4f1a\u662f\u8be5\u9886\u57df\u7684\u8bb8\u591a\u516c\u53f8\u672a\u6765\u9762\u4e34\u7684\u4e00\u4e2a\u96be\u9898\u3002\u6216\u8bb8\u4e13\u6ce8\u4e8e\u81ea\u8eab\u514d\u75ab\u75c5\u4e0e\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u7684\u7814\u7a76\u4f1a\u6210\u4e3a\u5f88\u591a\u516c\u53f8\u5bfb\u6c42\u5dee\u5f02\u5316\u7684\u65b0\u65b9\u5f0f\u3002<\/span><\/p>\n


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\u8f6c\u8f7d\u81ea\uff1a\u533b\u836f\u9b54\u65b9 <\/span>  \u5982\u6709\u4fb5\u6743\u8bf7\u8054\u7cfb\u5220\u9664<\/span><\/p>\n

\"CAR-T\u6cbb\u7597\u65b0\u65b9\u5411\uff1a\u81ea\u8eab\u514d\u75ab\u75c5\u4e0e\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\"
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\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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