{"id":51500,"date":"2018-09-21T01:00:00","date_gmt":"2018-09-26T02:19:23","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/26\/%e5%a5%bd%e6%b6%88%e6%81%af%e4%b8%a8%e8%bf%99%e6%ac%be%e7%be%8e%e5%9b%bd%e4%b8%b4%e5%ba%8a%e6%b2%bb%e7%96%97%e5%8d%b5%e5%b7%a2%e7%99%8c%e6%9c%80%e5%b8%b8%e7%94%a8%e7%9a%84parp%e6%8a%91%e5%88%b6\/"},"modified":"2018-09-26T10:19:26","modified_gmt":"2018-09-26T02:19:26","slug":"%e5%a5%bd%e6%b6%88%e6%81%af%e4%b8%a8%e8%bf%99%e6%ac%be%e7%be%8e%e5%9b%bd%e4%b8%b4%e5%ba%8a%e6%b2%bb%e7%96%97%e5%8d%b5%e5%b7%a2%e7%99%8c%e6%9c%80%e5%b8%b8%e7%94%a8%e7%9a%84parp%e6%8a%91%e5%88%b6","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/51500\/","title":{"rendered":"\u597d\u6d88\u606f\u4e28\u8fd9\u6b3e\u7f8e\u56fd\u4e34\u5e8a\u6cbb\u7597\u5375\u5de2\u764c\u6700\u5e38\u7528\u7684PARP\u6291\u5236\u5242\u5c06\u8981\u6765\u4e2d\u56fd\u4e86"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: circle;\">\n<li>\n<p style=\"margin-bottom: 10px;\"><span style=\"font-size: 15px;\">\u5375\u5de2\u764c\u53d1\u75c5\u7387\u5c45\u5973\u6027\u751f\u6b96\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u7b2c\u4e09\u4f4d\uff0c\u6b7b\u4ea1\u7387\u5c45\u5987\u79d1\u6076\u6027\u80bf\u7624\u4e4b\u9996[1]\uff0c\u5b58\u5728\u5de8\u5927\u7684\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42<\/span><\/p>\n<\/li>\n<li>\n<p style=\"margin-bottom: 10px;\"><span style=\"font-size: 15px;\">Niraparib\u4f5c\u4e3a\u5168\u7403\u9886\u5148\u7684PARP\u6291\u5236\u5242\uff0c\u5728\u94c2\u654f\u611f\u590d\u53d1\u5375\u5de2\u764c\u4e2d\u5404\u4e9a\u7ec4\u4e2d\u5747\u6709\u6548\u5ef6\u957f\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color: rgb(0, 147, 221);\"><strong><span style=\"color: rgb(0, 147, 221);font-size: 15px;\">Niraparib\u662f\u7f8e\u56fd\u4e34\u5e8a\u6cbb\u7597\u5375\u5de2\u764c\u6700\u5e38\u7528\u7684PARP\u6291\u5236\u5242\uff0c\u6709\u671b\u4eca\u5e74\u7b2c\u56db\u5b63\u5ea6\u5728\u9999\u6e2f\u4e0a\u5e02\uff0c\u968f\u540e\u5728\u6fb3\u95e8\u4e0a\u5e02\uff0c\u8ba9\u66f4\u591a\u5375\u5de2\u764c\u60a3\u8005\u83b7\u76ca<\/span><\/strong><\/span><\/p>\n<\/li>\n<\/ul>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 15px;\">\u518d\u9f0e\u533b\u836f\u4eca\u65e5\u643a\u91cd\u78c5\u4ea7\u54c1ZL-2306\uff08Niraparib\uff09\u9996\u6b21\u4eae\u76f82018\u5e74CSCO\u5b66\u672f\u5e74\u4f1a\u3002<\/span><span style=\"color: rgb(0, 147, 221);\"><strong><span style=\"font-size: 15px;\">Niraparib\u662f\u5168\u7403\u7b2c\u4e00\u4e2a\u83b7\u6279\u7528\u4e8e\u6240\u6709\u94c2\u654f\u611f\u590d\u53d1\u5375\u5de2\u764c\u60a3\u8005\u7684PARP\u6291\u5236\u5242\uff0c\u4e5f\u5c06\u662f\u518d\u9f0e\u533b\u836f\u81ea\u516c\u53f8\u6210\u7acb\u4ee5\u6765\uff0c\u5168\u7403\u8303\u56f4\u5185\u9996\u4e2a\u5546\u4e1a\u4e0a\u5e02\u7684\u4ea7\u54c1\u3002<\/span><\/strong><\/span><span style=\"font-size: 15px;\">\u672c\u6b21CSCO\u5e74\u4f1a\u4e0a\uff0c\u518d\u9f0e\u516c\u5e03\u4e86\u4e00\u9879\u8bc4\u4ef7Niraparib\u5728\u4e2d\u56fd\u5375\u5de2\u764c\u60a3\u8005\u4e2d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u5b89\u5168\u6027\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u2014\u2014\u8fd9\u662fNiraparib<\/span><span style=\"font-size: 15px;color: rgb(0, 147, 221);\"><strong>\u7b2c\u4e00\u4e2a\u5728\u4e2d\u56fd\u53ca\u4e9a\u6d32\u60a3\u8005\u4e2d\u7684\u6570\u636e\u3002<\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 15px;\">\u518d\u9f0e\u533b\u836f\u6b64\u6b21\u516c\u5e03\u7684\u5bf9\u4e8e\u4e2d\u56fd\u751f\u4ea7\u7684ZL-2306\uff08Niraparib\uff09\u5728\u4e2d\u56fd\u5375\u5de2\u764c\u60a3\u8005\u4e2d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u7279\u5f81\u7684\u8bc4\u4f30\uff0c<\/span><span style=\"font-size: 15px;color: rgb(0, 147, 221);\"><strong>\u9996\u6b21\u8bc1\u660e\u4e86ZL-2306\uff08Niraparib\uff09\u5728\u4e9a\u6d32\u60a3\u8005\u4e2dPK\u7279\u5f81\u4e0e\u897f\u65b9\u60a3\u8005\u76f8\u4f3c\uff0c\u65e0\u660e\u663e\u4eba\u79cd\u5dee\u5f02\uff0c<\/strong><\/span><span style=\"font-size: 15px;\">\u4e14\u672a\u53d1\u73b0\u9884\u671f\u5916\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002\u8be5\u7ed3\u679c\u4e5f\u5c06\u7528\u4e8eZL-2306\uff08Niraparib\uff09\u5728\u4e2d\u56fd\u6ce8\u518c\u7684\u5ba1\u8bc4\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1537928364.jpeg\" alt=\"\u597d\u6d88\u606f\u4e28\u8fd9\u6b3e\u7f8e\u56fd\u4e34\u5e8a\u6cbb\u7597\u5375\u5de2\u764c\u6700\u5e38\u7528\u7684PARP\u6291\u5236\u5242\u5c06\u8981\u6765\u4e2d\u56fd\u4e86\" title=\"\u597d\u6d88\u606f\u4e28\u8fd9\u6b3e\u7f8e\u56fd\u4e34\u5e8a\u6cbb\u7597\u5375\u5de2\u764c\u6700\u5e38\u7528\u7684PARP\u6291\u5236\u5242\u5c06\u8981\u6765\u4e2d\u56fd\u4e86\"  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><strong><span style=\"font-size: 15px;\">\u518d\u9f0e\u533b\u836f\u9996\u5e2d\u5546\u52a1\u5b98\u3001\u5927\u4e2d\u534e\u533a\u603b\u88c1 \u6881\u6021 \u5148\u751f\uff1a<\/span><\/strong><br  \/><\/p>\n<p style=\"margin-right: 32px;margin-left: 32px;white-space: normal;\"><em><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u201cZL-2306\uff08Niraparib\uff09\u5c06\u662f\u518d\u9f0e\u533b\u836f\u521b\u7acb\u4ee5\u6765\u5168\u7403\u8303\u56f4\u5185\u5546\u4e1a\u4e0a\u5e02\u7684\u7b2c\u4e00\u4e2a\u4ea7\u54c1\uff0c\u6211\u4eec\u5e0c\u671b\u5b83\u80fd\u591f\u6210\u4e3a\u60e0\u53ca\u66f4\u591a\u5375\u5de2\u764c\u60a3\u8005\u7684PARP\u6291\u5236\u5242\uff0c\u4e3a\u60a3\u8005\u6253\u5f00\u6218\u80dc\u75be\u75c5\u7684\u53e6\u4e00\u6247\u7a97\u3002\u201d<\/span><\/em><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 15px;\">\u5375\u5de2\u764c\u662f\u5e38\u89c1\u7684\u5987\u79d1\u6076\u6027\u80bf\u7624\u4e4b\u4e00\uff0c<\/span><span style=\"font-size: 15px;color: rgb(0, 147, 221);\"><strong>\u53d1\u75c5\u7387\u5c45\u5973\u6027\u751f\u6b96\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u7b2c\u4e09\u4f4d\uff0c\u6b7b\u4ea1\u7387\u5c45\u5987\u79d1\u6076\u6027\u80bf\u7624\u4e4b\u9996\u3002<\/strong><\/span><span style=\"font-size: 15px;\">\u7531\u4e8e\u8d77\u75c5\u9690\u533f\uff0c<\/span><span style=\"font-size: 15px;color: rgb(0, 147, 221);\"><strong>70%\u7684\u60a3\u8005\u53d1\u73b0\u65f6\u5df2\u662f\u665a\u671f\u3002<\/strong><\/span><span style=\"font-size: 15px;\">\u8fc7\u53bb30\u5e74\uff0c\u5375\u5de2\u764c\u7684\u4e3b\u8981\u6cbb\u7597\u624b\u6bb5\u4ee5\u624b\u672f\u548c\u5316\u7597\u4e3a\u4e3b\uff0c\u6839\u636e\u56fd\u5bb6\u764c\u75c7\u4e2d\u5fc3\u57fa\u4e8e2003\u81f32015\u5e74\u7684\u4e2d\u56fd\u764c\u75c7\u60a3\u8005\u6570\u636e\uff0c<\/span><span style=\"font-size: 15px;color: rgb(0, 147, 221);\"><strong>\u5375\u5de2\u764c\u60a3\u80055\u5e74\u751f\u5b58\u7387\u8fd1\u5341\u5e74\u6765\u65e0\u660e\u663e\u53d8\u5316\u3002<\/strong><\/span><br  \/><span style=\"font-size: 15px;\"><\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 15px;\">\u76ee\u524d\uff0c\u6211\u56fd\u5375\u5de2\u764c\u7684\u6cbb\u7597\u4ee5\u201c\u624b\u672f\u53ca\u4ee5\u94c2\u548c\u7d2b\u6749\u9187\u4e3a\u57fa\u7840\u7684\u5316\u7597\u65b9\u6848\u201d\u4e3a\u4e3b\uff0c\u76f8\u5f53\u90e8\u5206\u60a3\u8005\u7684\u75c5\u60c5\u5f97\u5230\u7f13\u89e3\uff0c\u4f46\u5374\u65e0\u6cd5\u663e\u8457\u5ef6\u957f\u80bf\u7624\u590d\u53d1\u7684\u95f4\u9694\u65f6\u95f4\u548c\u751f\u5b58\u671f\uff0c<\/span><span style=\"font-size: 15px;color: rgb(0, 147, 221);\"><strong>\u5375\u5de2\u764c\u7684\u590d\u53d1\u7387\u9ad8\u8fbe70%\u3002<\/strong><\/span><span style=\"font-size: 15px;\">\u800c\u957f\u671f\u5316\u7597\u5e26\u6765\u7684\u5267\u70c8\u6bd2\u526f\u4f5c\u7528\u8ba9\u60a3\u8005\u7684\u751f\u5b58\u8d28\u91cf\u96be\u4ee5\u4fdd\u969c\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1537928365.jpeg\" alt=\"\u597d\u6d88\u606f\u4e28\u8fd9\u6b3e\u7f8e\u56fd\u4e34\u5e8a\u6cbb\u7597\u5375\u5de2\u764c\u6700\u5e38\u7528\u7684PARP\u6291\u5236\u5242\u5c06\u8981\u6765\u4e2d\u56fd\u4e86\" title=\"\u597d\u6d88\u606f\u4e28\u8fd9\u6b3e\u7f8e\u56fd\u4e34\u5e8a\u6cbb\u7597\u5375\u5de2\u764c\u6700\u5e38\u7528\u7684PARP\u6291\u5236\u5242\u5c06\u8981\u6765\u4e2d\u56fd\u4e86\"  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><strong><span style=\"font-size: 15px;\">\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5987\u79d1\u4e3b\u4efb \u5218\u7ee7\u7ea2 \u6559\u6388\uff1a<\/span><\/strong><\/p>\n<p style=\"margin-right: 32px;margin-left: 32px;white-space: normal;text-align: center;\"><em><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u201c\u5375\u5de2\u764c\u9886\u57df\u5b58\u5728\u7740\u5de8\u5927\u7684\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u6cbb\u7597\u9700\u6c42\uff0c<\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5982\u4f55\u5e2e\u52a9\u60a3\u8005\u63d0<\/span><\/em><em><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9ad8\u751f\u5b58\u8d28\u91cf\u3001\u5ef6\u957f\u751f\u547d\u662f\u6211\u4eec\u5f53\u4e0b\u6cbb\u7597\u5375\u5de2\u764c\u7684\u96be\u9898\u3002\u201d<\/span><\/em><\/p>\n<p><br  \/><\/p>\n<p><span style=\"color: rgb(0, 147, 221);\"><strong><span style=\"font-size: 15px;\">Niraparib\u4e8e2017\u5e743\u6708\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u7684\u6279\u51c6\u4e0a\u5e02\uff0c<\/span><\/strong><\/span><span style=\"font-size: 15px;\">\u7528\u4e8e\u590d\u53d1\u6027\u4e0a\u76ae\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u5973\u6027\u60a3\u8005\u7684\u7ef4\u6301\u6cbb\u7597\uff0c<\/span><span style=\"font-size: 15px;color: rgb(0, 147, 221);\"><strong>\u662f\u5168\u7403\u7b2c\u4e00\u4e2a\u83b7\u6279\u7684\u9002\u7528\u4e8e\u6240\u6709\u94c2\u654f\u611f\u590d\u53d1\u5375\u5de2\u764c\u60a3\u8005\u7fa4\u4f53\u3001\u800c\u65e0\u8bbaBRCA\u662f\u5426\u7a81\u53d8\u7684PARP\u6291\u5236\u5242\u3002<\/strong><\/span><span style=\"font-size: 15px;\">\u6839\u636e\u7f8e\u56fd\u7684\u4e00\u9879\u7814\u7a76\uff0c2017\u5e744\u6708\u81f32018\u5e744\u6708\u671f\u95f4\uff0cNiraparib\u662f\u7f8e\u56fd\u4e34\u5e8a\u6cbb\u7597\u5375\u5de2\u764c\u6700\u5e38\u7528\u7684PARP\u6291\u5236\u5242\uff1b\u5728212\u4f8b\u7ecfPARP\u6291\u5236\u5242\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u670962%\u63a5\u53d7Niraparib\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 15px;\">2016\u5e74\uff0c\u4e00\u9879III\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff08NOVA\uff09\u663e\u793a<\/span><span style=\"font-size: 15px;color: rgb(0, 147, 221);\"><strong>Niraparib\u80fd\u6709\u6548\u5ef6\u7f13\u5375\u5de2\u764c\u60a3\u8005\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff1a<\/strong><\/span><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: circle;\">\n<li>\n<p style=\"margin-bottom: 10px;\"><span style=\"font-size: 15px;\">\u5e94\u7528Niraparib\u7684BRCA\u7a81\u53d8\u60a3\u8005\u4e2d\uff0c\u4e2d\u4f4dPFS\u8fbe21\u6708\uff0c\u76f8\u8f83\u5b89\u6170\u5242\u7ec45.5\u6708\u6709\u660e\u663e\u4f18\u52bf\uff0c\u6574\u4f53\u6b7b\u4ea1\u98ce\u9669\u4e0b\u8c0373%\uff1b\u968f\u8bbf\u81f318\u4e2a\u6708\uff0cNiraparib\u7ec450%\u7684\u60a3\u8005\u8fd8\u672a\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 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