{"id":52639,"date":"2018-09-27T01:00:00","date_gmt":"2018-09-30T01:36:06","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e5%bf%ab%e8%ae%af%ef%bc%9a%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9ebtk%e8%b5%9e%e5%b8%83%e6%9b%bf%e5%b0%bc%ef%bc%8c%e5%95%86%e5%93%81%e5%90%8d%e5%b7%b2%e5%ae%9a%e7%99%be%e6%82%a6%e6%b4%8b\/"},"modified":"2018-09-30T09:36:08","modified_gmt":"2018-09-30T01:36:08","slug":"%e5%bf%ab%e8%ae%af%ef%bc%9a%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9ebtk%e8%b5%9e%e5%b8%83%e6%9b%bf%e5%b0%bc%ef%bc%8c%e5%95%86%e5%93%81%e5%90%8d%e5%b7%b2%e5%ae%9a%e7%99%be%e6%82%a6%e6%b4%8b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/52639\/","title":{"rendered":"\u5feb\u8baf\uff1a\u767e\u6d4e\u795e\u5ddeBTK\u8d5e\u5e03\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\u5df2\u5b9a#\u767e\u60a6\u6d0b#"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1538271366.jpg\" alt=\"\u5feb\u8baf\uff1a\u767e\u6d4e\u795e\u5ddeBTK\u8d5e\u5e03\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\u5df2\u5b9a#\u767e\u60a6\u6d0b#\" title=\"\u5feb\u8baf\uff1a\u767e\u6d4e\u795e\u5ddeBTK\u8d5e\u5e03\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\u5df2\u5b9a#\u767e\u60a6\u6d0b#\"  \/><\/p>\n<h2 class=\"rich_media_title\" style=\"margin-bottom: 14px;font-size: 22px;line-height: 1.4;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;widows: 1;zoom: 0.888889;background-color: rgb(255, 255, 255);\"><br  \/><\/h2>\n<h2 class=\"rich_media_title\">\u767e\u6d4e\u795e\u5dde\u6838\u5fc3\u8d44\u4ea7\uff0cBTK\u901a\u7528\u540d,\u5b9a\u4e3a\u8d5e\u5e03\u66ff\u5c3c\uff0c\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u4e8e2018\u5e748\u670829\u65e5\u83b7\u5f97CDE\u627f\u529e\u516c\u793a\u3002<\/h2>\n<h2 class=\"rich_media_title\"><span style=\"font-size: 12px;\"><br  \/><\/span><\/h2>\n<h2 class=\"rich_media_title\"><span style=\"font-size: 12px;\">\u7b14\u8005\u9884\u8ba1\u6700\u5feb6\u4e2a\u6708\u53ef\u83b7\u6279\u4e0a\u5e02\uff0c\u610f\u89c1\u4ec5\u4f9b\u53c2\u8003\uff0c\u4e0d\u4f5c\u4e3a\u6295\u8d44\u5efa\u8bae\u3002<\/span><\/h2>\n<p><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"      style=\"zoom: 0.888889;box-sizing: border-box !important;word-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1538271367.jpg\" alt=\"\u5feb\u8baf\uff1a\u767e\u6d4e\u795e\u5ddeBTK\u8d5e\u5e03\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\u5df2\u5b9a#\u767e\u60a6\u6d0b#\" title=\"\u5feb\u8baf\uff1a\u767e\u6d4e\u795e\u5ddeBTK\u8d5e\u5e03\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\u5df2\u5b9a#\u767e\u60a6\u6d0b#\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">1.Zanubrutinib((BGB-3111)\uff0c\u4e00\u6b3e\u5728\u7814\u7684\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5242\uff0c\u4f5c\u4e3a\u9488\u5bf9<span style=\"max-width: 100%;background-color: rgb(255, 215, 213);box-sizing: border-box !important;word-wrap: break-word !important;\">\u590d\u53d1\/\u96be\u6cbb\u6027\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09<\/span>\u60a3\u8005\u6f5c\u5728\u7597\u6cd5\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\u3002Zanubrutinib\u7531\u767e\u6d4e\u795e\u5dde\u4f4d\u4e8e\u4e2d\u56fd\u5317\u4eac\u7684\u79d1\u7814\u4e2d\u5fc3\u53d1\u73b0\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">2.\u8fd9\u9879NDA\u662f\u57fa\u4e8e\u767e\u6d4e\u795e\u5dde\u5e7f\u6cdb\u7684\u4e34\u5e8a\u548c\u975e\u4e34\u5e8a\u6570\u636e\uff0c\u5305\u62ec\u9488\u5bf986\u4f4d\u590d\u53d1\u6216\u96be\u6cbb\u6027\u4e2d\u56fdMCL\u60a3\u8005\u4ee5\u6bcf\u6b21160mg\u3001\u6bcf\u65e5\u4e24\u6b21\u5242\u91cf\u8fdb\u884c\u7684<span style=\"max-width: 100%;background-color: rgb(255, 215, 213);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5355\u81c2\u5173\u952e\u60272\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002<\/span>\u5bf9\u8fd9\u9879\u8bd5\u9a8c\u7597\u6548\u6570\u636e\u7684\u72ec\u7acb\u8bc4\u5ba1\u7ed3\u679c\u663e\u793a<span style=\"max-width: 100%;background-color: rgb(255, 215, 213);box-sizing: border-box !important;word-wrap: break-word !important;\">\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a84%<\/span>\uff0c\u5305\u62ec<span style=\"max-width: 100%;background-color: rgb(255, 215, 213);box-sizing: border-box !important;word-wrap: break-word !important;\">59%\u7684\u75c5\u4eba\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09<\/span>\u3002\u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a8.3\u4e2a\u6708\u7684\u60c5\u51b5\u4e0b\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4(mDOR)\u5c1a\u672a\u8fbe\u5230\uff0c\u56e0\u4e3a\u7814\u7a76\u4e2d\u8d85\u8fc7\u4e00\u534a\u6709\u7f13\u89e3\u7684\u60a3\u8005\u4ecd\u5bf9\u6cbb\u7597\u6709\u54cd\u5e94\u3002<span style=\"max-width: 100%;background-color: rgb(255, 215, 213);box-sizing: border-box !important;word-wrap: break-word !important;\">(\u7533\u8bf7\u6709\u6761\u4ef6\u6279\u51c6)<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"     style=\"zoom: 0.888889;box-sizing: border-box !important;word-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1538271368.jpg\" alt=\"\u5feb\u8baf\uff1a\u767e\u6d4e\u795e\u5ddeBTK\u8d5e\u5e03\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\u5df2\u5b9a#\u767e\u60a6\u6d0b#\" title=\"\u5feb\u8baf\uff1a\u767e\u6d4e\u795e\u5ddeBTK\u8d5e\u5e03\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\u5df2\u5b9a#\u767e\u60a6\u6d0b#\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(25, 25, 25);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;letter-spacing: 0.483556px;line-height: 22.7556px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 13px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(192, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u53c2\u8003\uff1a<\/span><\/strong><\/span><\/p>\n<h1 style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\">NMPA\/CDE\uff1b<\/span><\/h1>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u836f\u878d\u6570\u636e\uff0cPharnex &nbsp;Datamonitor;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u76f8\u5173\u516c\u53f8\u516c\u5f00\u62ab\u9732\u7b49\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\"><img   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1538271368.jpg\" alt=\"\u5feb\u8baf\uff1a\u767e\u6d4e\u795e\u5ddeBTK\u8d5e\u5e03\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\u5df2\u5b9a#\u767e\u60a6\u6d0b#\" title=\"\u5feb\u8baf\uff1a\u767e\u6d4e\u795e\u5ddeBTK\u8d5e\u5e03\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\u5df2\u5b9a#\u767e\u60a6\u6d0b#\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(171, 25, 66);background-color: rgb(255, 215, 213);box-sizing: border-box !important;word-wrap: break-word !important;\">\u836f\u878d\u5708\u4e3a\u836f\u7269\u7b80\u8baf\u5408\u4f5c\u5e73\u53f0.<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u767e\u6d4e\u795e\u5dde\u6838\u5fc3\u8d44\u4ea7\uff0cBTK\u901a\u7528\u540d,\u5b9a\u4e3a\u8d5e\u5e03\u66ff\u5c3c\uff0c\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u4e8e2018\u5e748\u670829\u65e5\u83b7\u5f97CDE\u627f\u529e\u516c\u793a\u3002 \u7b14 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":52640,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/52639"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=52639"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/52639\/revisions"}],"predecessor-version":[{"id":52645,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/52639\/revisions\/52645"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/52640"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=52639"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=52639"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=52639"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}