{"id":52652,"date":"2018-09-28T01:00:00","date_gmt":"2018-09-30T01:36:16","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e8%bf%91%e4%b8%80%e4%b8%aa%e6%9c%88%e8%8d%af%e7%89%a9%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e6%a6%82%e8%a7%88\/"},"modified":"2018-09-30T09:36:20","modified_gmt":"2018-09-30T01:36:20","slug":"%e8%bf%91%e4%b8%80%e4%b8%aa%e6%9c%88%e8%8d%af%e7%89%a9%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e6%a6%82%e8%a7%88","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/52652\/","title":{"rendered":"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982\u89c8"},"content":{"rendered":"
\n

\u672c\u6587\u4f9d\u636eInforma\u6570\u636e\u5e93\u68b3\u7406\u4e86\u8fd1\u4e00\u4e2a\u6708\uff082018\u5e748\u670810\u65e5\uff5e2018\u5e749\u670813\u65e5\uff09\u5728\u7814\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982\u51b5\u3002\u5728\u68c0\u7d22\u65f6\u95f4\u5185\uff0c\u670970\u4e2a\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u79ef\u6781\u8fdb\u5c55\uff08\u8bc4\u4ef7\u6307\u6807\u4e3aInforma\u6570\u636e\u5e93\u836f\u7269\u8bc4\u5206\u6307\u6807\u63d0\u5347\uff09\uff0c\u5176\u4e2d\uff0c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u5c0f\u5206\u5b50\u6291\u5236\u5242\u6548\u679c\u663e\u8457\uff0c\u5305\u62ec\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u516c\u53f8\u94f6\u5c51\u75c5\u65b0\u836fBMS-986165\u53ca\u5409\u5229\u5fb7\u516c\u53f8\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u65b0\u836fFilgotinib\uff0c\u4e8c\u8005\u5747\u4e3aJAK\u6291\u5236\u5242\uff0c\u524d\u8005\u7279\u5f02\u9776\u5411TYK2\uff0c\u540e\u8005\u9009\u62e9\u6027\u4f5c\u7528JAK1\uff0c\u5747\u663e\u793a\u51fa\u8f83\u597d\u7684\u6cbb\u7597\u6548\u679c\u548c\u8f83\u9ad8\u7684\u5b89\u5168\u6027\uff1b\u670938\u4e2a\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u4e0d\u7406\u60f3\uff08\u8bc4\u4ef7\u6307\u6807\u4e3aInforma\u6570\u636e\u5e93\u836f\u7269\u8bc4\u5206\u6307\u6807\u964d\u4f4e\uff09\uff0c\u5176\u4e2d\u5305\u62ecGemphire\u516c\u53f8\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u836fGemcabene\uff0c\u7531\u4e8e\u5b89\u5168\u6027\u95ee\u9898\uff0cFDA\u4e0d\u540c\u610f\u5176\u5f00\u5c55\u8fdb\u4e00\u6b65\u7684\u957f\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u53e6\u6709\u963f\u65af\u5229\u5eb7\u516c\u53f8\u7814\u53d1\u7684\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u836f\u7269Anifrolumab\u7684\u4e34\u5e8a\u2162\u671f\u7814\u7a76\u672a\u80fd\u5230\u8fbe\u75be\u75c5\u6d3b\u52a8\u663e\u7740\u964d\u4f4e\u7684\u4e3b\u8981\u7ec8\u70b9\u7b49\uff1b\u6b64\u5916\uff0c\u672c\u6708\u670954\u4e2a\u836f\u7269\uff08\u9002\u5e94\u75c7\uff09\u9996\u6b21\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002\u672c\u6587\u4e3b\u8981\u5bf9\u8fd1\u4e00\u4e2a\u6708\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\u60c5\u51b5\u8fdb\u884c\u76d8\u70b9\uff0c\u5e76\u7740\u91cd\u4ecb\u7ecd\u90e8\u5206\u836f\u7269\u7684\u4e34\u5e8a\u5173\u952e\u4e8b\u4ef6\uff0c\u4f9b\u7814\u53d1\u4eba\u5458\u53c2\u8003\u3002<\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982\u89c8\"<\/strong><\/section>\n
\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982\u89c8\"<\/strong><\/section>\n
\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982\u89c8\"<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\u4e34\u5e8a\u8bd5\u9a8c\u79ef\u6781\u8fdb\u5c55\u4e8b\u4ef6<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u5728\u68c0\u7d22\u65f6\u95f4\u5185\uff0c\u670970\u4e2a\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u79ef\u6781\u8fdb\u5c55\uff08\u88681\uff0c\u6309\u65f6\u95f4\u6392\u5e8f\uff09\uff0c\u4e0b\u9762\u5bf9\u90e8\u5206\u836f\u7269\u7684\u91cd\u8981\u4e34\u5e8a\u8bd5\u9a8c\u60c5\u51b5\u8fdb\u884c\u4ecb\u7ecd\u3002<\/span>
<\/p>\n

\u88681\uff1a2018\u5e748\u670810\u65e5\uff5e2018\u5e749\u670813\u65e5\u4e34\u5e8a\u8bd5\u9a8c\u6709\u79ef\u6781\u8fdb\u5c55\u7684\u836f\u7269<\/span><\/p>\n

\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982\u89c8\"<\/p>\n

\u6ce8\uff1a\u5176\u4e2d\u5bf9\u7ea2\u8272\u6807\u6ce8\u7684\u836f\u7269\u4f5c\u91cd\u70b9\u4ecb\u7ecd<\/span><\/p>\n

Fasinumab<\/strong><\/span><\/p>\n

Fasinumab\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u7684\u795e\u7ecf\u751f\u957f\u56e0\u5b50\uff08Nerve Growth Factor\uff0cNGF\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u901a\u8fc7\u4e0eNGF\u7ed3\u5408\u53ef\u4ee5\u963b\u65adNGF\u5728\u75db\u89c9\u4ea7\u751f\u65b9\u9762\u7684\u4f5c\u7528\u3002\u7531\u518d\u751f\u5143\u516c\u53f8\u4e0e\u68af\u74e6\u516c\u53f8\u8054\u5408\u5f00\u53d1\uff0c\u8fd1\u65e5\uff0cfasinumab\u5728\u6cbb\u7597\u56e0\u81c0\u90e8\u548c\u819d\u76d6\u9aa8\u6027\u5173\u8282\u708e\uff08osteoarthritis\uff0cOA\uff09\u5bfc\u81f4\u7684\u6162\u6027\u75bc\u75db\u7684\u4e34\u5e8a\u2162\u671f\u8bd5\u9a8c\u4e2d\u8fbe\u5230\u5171\u540c\u4e3b\u8981\u7ec8\u70b9\u4ee5\u53ca\u6240\u6709\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u3002\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u63a5\u53d7fasinumab\u6cbb\u7597\u7684\u60a3\u8005\u611f\u53d7\u5230\u7684\u75bc\u75db\u660e\u663e\u51cf\u8f7b\uff0c\u800c\u4e14\u8fd0\u52a8\u80fd\u529b\u83b7\u5f97\u663e\u8457\u6539\u5584\u3002<\/span><\/p>\n

\u5728\u8fd9\u9879\u968f\u673a\u53cc\u76f2\uff0c\u542b\u5b89\u6170\u5242\u5bf9\u7167\u7684\u4e34\u5e8a\u2162\u671f\u8bd5\u9a8c\u4e2d\uff0c649\u540d\u56e0\u4e3a\u81c0\u90e8\u6216\u819d\u76d6OA\u4ea7\u751f\u75bc\u75db\u7684\u60a3\u8005\u88ab\u5206\u4e3a\u4e09\u7ec4\uff0c\u63a5\u53d7\u4e86\u4e0d\u540c\u5242\u91cf\u7684fasinumab\u6216\u5b89\u6170\u5242\u7684\u6cbb\u7597\uff0c\u5176\u4e2d\uff0c85\uff05\u60a3\u8005\u7684OA\u4f4d\u4e8e\u819d\u76d6\u90e8\u4f4d\u3002\u7814\u7a76\u7684\u5171\u540c\u4e3b\u8981\u7ec8\u70b9\u4e3a\u63a5\u53d7\u6cbb\u759716\u5468\u4e4b\u540e\uff0c\u75bc\u75db\u6c34\u5e73\u4e0e\u57fa\u7ebf\u6c34\u5e73\u76f8\u6bd4\u7684\u53d8\u5316\uff0c\u4ee5\u53ca\u8fd0\u52a8\u529f\u80fd\u4e0e\u57fa\u7ebf\u6c34\u5e73\u76f8\u6bd4\u7684\u53d8\u5316\u3002\u7814\u7a76\u4eba\u5458\u4f7f\u7528WOMAC\u7684\u75bc\u75db\u91cf\u8868\u8bc4\u5206\u548c\u8fd0\u52a8\u529f\u80fd\u91cf\u8868\u8bc4\u5206\u6765\u68c0\u6d4b\u60a3\u8005\u7684\u75bc\u75db\u548c\u8fd0\u52a8\u529f\u80fd\u6c34\u5e73\uff08\u5206\u503c\u533a\u95f4\uff1a0\uff0d10\uff09\u3002\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u5728\u63a5\u53d7\u6cbb\u759716\u5468\u4e4b\u540e\uff0c\u4e24\u79cd\u4e0d\u540c\u5242\u91cf\u7684fasinumab\u7597\u6cd5\u90fd\u80fd\u591f\u663e\u8457\u964d\u4f4e\u60a3\u8005\u7684\u75bc\u75db\u6c34\u5e73\u3002\u5728\u6bcf\u516b\u5468\u63a5\u53d7\u4e00\u6b21\u5242\u91cf\u4e3a1mg\u7684fasinumab\u6ce8\u5c04\u7684\u60a3\u8005\u4e2d\uff0c\u75bc\u75db\u6c34\u5e73\u5e73\u5747\u964d\u4f4e\u4e862.25\uff08p=0.0019\uff09\uff1b\u5728\u6bcf\u56db\u5468\u63a5\u53d7\u4e00\u6b21\u5242\u91cf\u4e3a1mg\u7684fasinumab\u6ce8\u5c04\u7684\u60a3\u8005\u4e2d\uff0c\u75bc\u75db\u6c34\u5e73\u964d\u4f4e\u4e862.78\uff08p<0.0001\uff09\u3002\u5b89\u6170\u5242\u7ec4\u75bc\u75db\u6c34\u5e73\u7684\u51cf\u5c11\u53ea\u67091.56\u3002\u5728\u8fd0\u52a8\u80fd\u529b\u65b9\u9762\uff0c\u6bcf\u516b\u5468\u63a5\u53d7\u4e00\u6b21\u6ce8\u5c04\u7684\u60a3\u8005\u8fd0\u52a8\u6c34\u5e73\u5e73\u5747\u6539\u55842.10\uff08p=0.0011\uff09\uff0c\u56db\u5468\u4e00\u6b21\u7684\u60a3\u8005\u8fd0\u52a8\u6c34\u5e73\u6539\u55842.57\uff08p<0.0001\uff09\u3002\u5b89\u6170\u5242\u7ec4\u7684\u6539\u5584\u4e3a1.37\u3002\u572816\u5468\u65f6fasinumab\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u8868\u73b0\u4e0e\u4ee5\u524d\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u8868\u73b0\u76f8\u540c\u3002<\/span><\/p>\n

MC2-01<\/strong><\/span><\/p>\n

MC2-01\u4e73\u818f\u7684\u6d3b\u6027\u6210\u5206\u4e3a\u5361\u6cca\u4e09\u70ef\/\u4e8c\u4e19\u9178\u500d\u4ed6\u7c73\u677e\uff0c\u8be5\u836f\u7269\u5229\u7528\u4e86MC2 Therapeutics\u516c\u53f8PAD\u914d\u65b9\u6280\u672f\u5c06\u8fd9\u4e24\u79cd\u6210\u5206\u5236\u9020\u6210\u7a33\u5b9a\u7684\u6c34\u5305\u6cb9\u4e73\u5242\uff0c\u4f7f\u4e4b\u80fd\u591f\u8fc5\u901f\u88ab\u76ae\u80a4\u5438\u6536\uff0c\u540c\u65f6\u4fdd\u6301\u76ae\u80a4\u6e7f\u6da6\u3002\u60a3\u8005\u5728\u4f7f\u7528\u4e73\u5242\u4e4b\u540e\u53ef\u4ee5\u8fc5\u901f\u7a7f\u8863\u8fdb\u884c\u65e5\u5e38\u751f\u6d3b\u3002\u8fd1\u671fMC2 Therapeutics\u516c\u5e03\u4e86MC2-01\u4e73\u5242\u4e34\u5e8a\u2162\u671f\u7814\u7a76\u7684\u79ef\u6781\u9876\u7ebf\u6570\u636e\u3002MC2-01\u7684\u7814\u7a76\u663e\u793a\uff0c\u5176\u5728\u6cbb\u7597\u6210\u529f\u7387\u548c\u4fbf\u5229\u6027\u4e0a\u90fd\u8d85\u8fc7\u4e86\u5bf9\u7167\u836f\u7269taclonex\uff08\u5916\u7528\u60ac\u6d6e\u5242\uff09\u3002\u8bd5\u9a8c\u8fbe\u5230\u4e86\u4e3b\u8981\u53ca\u6b21\u8981\u7ec8\u70b9\uff0c\u516c\u53f8\u5df2\u8ba1\u5212\u57282019\u5e74\u4e0a\u534a\u5e74\u63d0\u4ea4NDA\u7533\u8bf7\u3002<\/span><\/p>\n

\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff1a\u6b64\u6b21\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4f9d\u636e\u533b\u5e08\u5168\u7403\u8bc4\u4f30\uff08PGA\uff09\u8bc4\u5206\u89c4\u5b9a\u7684\u6cbb\u7597\u6210\u529f\u5b9a\u4e49\uff0c\u76f8\u6bd4taclonex\u5916\u7528\u60ac\u6d6e\u5242\uff0cMC2-01\u4e73\u818f\u5728\u6cbb\u7597\u7b2c8\u5468\u65f6\u5177\u6709\u66f4\u4f18\u7684\u7597\u6548\uff0840.1%\u5bf924.0%\uff0cp<0.0001\uff09\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u8bd5\u9a8c\u8fbe\u5230\u4e86\u5b83\u7684\u4e3b\u8981\u7ec8\u70b9\uff0c\u8bc1\u660e\u4e86MC2-01\u4e73\u818f\u4e0etaclonex\u7684\u975e\u52a3\u6548\u6027\u3002\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\uff1a\u5bf9\u4e8emPASI\u4ece\u57fa\u7ebf\u964d\u81f3\u7b2c8\u5468\u7684\u767e\u5206\u6bd4\uff0cMC2-01\u4e73\u818f\u662f\u4f18\u4e8etaclone\u7684\uff0864.8% vs 52.3%, p < 0.0001\uff09\u3002MC2-01\u4e73\u818f\u5728\u7b2c1\u5468\u8868\u73b0\u51fa\u5feb\u901f\u8d77\u6548(p<0.001)\uff0c\u4f18\u4e8etaclonex\u3002MC2-01\u4e73\u818f\u5728\u75c5\u4eba\u6cbb\u7597\u4fbf\u5229\u6027\u65b9\u9762\u4f18\u4e8etaclonex (p<0.0001)\u3002\u901a\u8fc7\u7619\u75d2\u4e25\u91cd\u7a0b\u5ea611\u4e2a\u6570\u5b57\u7b49\u7ea7\u56db\u7ea7\u6216\u66f4\u9ad8\u7ea7\u7684\u6539\u5584\u9891\u7387\u6307\u6807\uff0cMC2-01\u4e73\u818f\u80fd\u6709\u6548\u5730\u51cf\u5c11\u7619\u75d2(\u5728\u7b2c4\u5468\u65f6\u4e3a60.2%)\u3002\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u7684\u4e0d\u826f\u53cd\u5e94\u5747\u53ef\u9884\u6d4b\uff0c\u901a\u5e38\u662f\u4e0e\u5361\u6cca\u4e09\u70ef\u548c\u5c40\u90e8\u76ae\u8d28\u7c7b\u56fa\u9187\u6709\u5173\u7684\u836f\u7406\u53cd\u5e94\uff0cMC2-01\u4e73\u818f\u7684\u5b89\u5168\u6027\u4e0etaclonex\u5df2\u77e5\u7684\u5b89\u5168\u6027\u8d28\u76f8\u4f3c\u3002<\/span><\/p>\n

ABX464<\/strong><\/span><\/p>\n

ABX464\u662f\u4e00\u79cd\u9996\u521b\uff08first-in-class\uff09\u7684\u53e3\u670d\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u6700\u521d\u5f00\u53d1\u7528\u4e8eHIV\u7684\u6cbb\u7597\uff0c\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u8868\u73b0\u51fa\u4e86\u5f3a\u70c8\u7684\u6297\u708e\u4f5c\u7528\u30029\u67085\u65e5\uff0cAbivax\u516c\u53f8\u516c\u5e03\u4e86\u5176\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff08UC\uff09\u2161a\u671f\u4e34\u5e8a\u8bd5\u9a8cABX464\u7684\u9876\u7ebf\u7ed3\u679c\uff1a\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u572832\u540d\u60a3\u8005\u4e2d\u8fdb\u884c\uff0c\u7528\u4e8e\u4e2d\u5ea6\u81f3\u91cd\u5ea6UC\u7684\u8bf1\u5bfc\u6cbb\u7597\uff0c\u8fd9\u4e9b\u60a3\u8005\u4f7f\u7528TNF\u5355\u514b\u9686\u6297\u4f53\u6216\u76ae\u8d28\u7c7b\u56fa\u9187\u6cbb\u7597\u6548\u679c\u4e0d\u4f73\uff0c\u9876\u7ebf\u6570\u636e\u8868\u660e\uff0cABX464\u5728\u4e34\u5e8a\u548c\u5185\u7aa5\u955c\u7ec8\u70b9\u4e0a\u8868\u73b0\u51fa\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u7597\u6548\uff0c\u5e76\u4e14\u5177\u5907\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u8be5\u4e34\u5e8a\u7814\u7a76\u5728\u516d\u4e2a\u6b27\u6d32\u56fd\u5bb6\u768415\u4e2a\u4e2d\u5fc3\u8fdb\u884c\uff0c\u62db\u52df\u60a3\u8005\u63092:1\u7684\u6bd4\u4f8b\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21ABX464\u53e3\u670d\u7247\u5242\u6216\u5b89\u6170\u5242\uff0c32\u540d\u60a3\u8005\u4e2d\u768429\u540d\u5df2\u7ecf\u6309\u7167\u65b9\u6848\u5b8c\u6210\u4e86\u7814\u7a76\u3002<\/span><\/p>\n

\u6700\u7ec88\u5468\u7684\u6570\u636e\u663e\u793a\uff0c35\uff05\u4f7f\u7528ABX464\u7684\u60a3\u8005\u83b7\u5f97\u4e86\u4e34\u5e8a\u7f13\u89e3\uff0c\u8fd9\u4e00\u6570\u636e\u5728\u5b89\u6170\u5242\u7ec4\u4e2d\u4e3a11\uff05\u3002\u5728\u7c98\u819c\u6108\u5408\u65b9\u9762\uff0c50\uff05\u4f7f\u7528ABX464\u7684\u60a3\u8005\u51fa\u73b0\u4e86\u79ef\u6781\u53cd\u5e94\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a11\uff05\u3002\u7ed3\u679c\u663e\u793a\uff0cABX464\u4ea7\u751f\u4e8670\uff05\u7684\u4e34\u5e8a\u7f13\u89e3\u7387\uff08clinical response rate\uff09\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a30\uff05\u3002\u6b64\u5916\uff0c\u5728\u6cbb\u75974\u5468\u540e\uff0c\u4e0e\u5b89\u6170\u5242\uff08\u6bd4\u57fa\u7ebf\u6c34\u5e73\u964d\u4f4e1.6\u500d\uff09\u76f8\u6bd4\uff0c\u63a5\u53d7ABX464\u7684\u60a3\u8005\u7684\u9499\u7ed3\u5408\u86cb\u767d\uff08calprotectin\uff09\u663e\u8457\u964d\u4f4e\uff08\u6bd4\u57fa\u7ebf\u6c34\u5e73\u964d\u4f4e4.4\u500d\uff09\uff0c\u5176\u4e2d\uff0c\u9499\u7ed3\u5408\u86cb\u767d\u662fUC\u4e2d\u7814\u7a76\u6700\u5b8c\u5907\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/span><\/p>\n

Flortaucipir F 18<\/strong><\/span><\/p>\n

\u8fd1\u65e5\uff0c\u7f8e\u56fd\u5236\u836f\u5de8\u5934\u793c\u6765\u53ca\u5176\u5168\u8d44\u5b50\u516c\u53f8Avid Radiopharmaceuticals\u5ba3\u5e03\uff0c\u4e00\u79cd\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\uff08PET\uff09\u663e\u50cf\u5242flortaucipir F18\u5728\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff08A16\uff09\u4e2d\u83b7\u5f97\u6210\u529f\uff0c\u8fbe\u5230\u4e86\u7814\u7a76\u7684\u4e24\u4e2a\u4e3b\u8981\u7ec8\u70b9\uff1a\u9884\u6d4b\u5927\u8111tau\u86cb\u767d\u75c5\u7406\u5b66\u4ee5\u53ca\u9884\u6d4b\u963f\u5c14\u8328\u6d77\u9ed8\uff08AD\uff09\u8bca\u65ad\u3002<\/span><\/p>\n

\u8fd9\u9879\u540d\u4e3aA16\u7684\u7814\u7a76\u4e2d\uff0c\u5171\u5165\u7ec4\u4e86156\u4f8b\u4f34\u6709\u75f4\u5446\u3001\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u6216\u6b63\u5e38\u8ba4\u77e5\u7684\u7ec8\u672b\u671f\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u63a5\u53d7\u4e86flortaucipir PET\u6210\u50cf\u3002\u968f\u540e\uff0c\u5176\u4e2d67\u4f8b\u60a3\u8005\u5728\u6b7b\u4ea1\u540e\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u7814\u7a76\u8fbe\u5230\u4e86\u9884\u5b9a\u4e49\u7684\u4e24\u4e2a\u7ec8\u70b9\uff1a1\uff09flortaucipir\u5728\u8bc6\u522bBraak\u5206\u671fV\/VI\u671ftau\u86cb\u767d\u75c5\u7406\u5b66\u65b9\u9762\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u654f\u611f\u6027\u548c\u7279\u5f02\u6027\uff0cBraak\u5206\u671fV\/VI\u662ftau\u795e\u7ecf\u7ea4\u7ef4\u7f20\u7ed3\u7684\u75c5\u7406\u5206\u671f\u91cf\u8868\uff1b2\uff09flortaucipir\u8fd8\u5728\u68c0\u6d4b\u9ad8\u6c34\u5e73\u7684\u603bAD\u795e\u7ecf\u75c5\u7406\u6539\u53d8\uff08tau\u548c\u6dc0\u7c89\u6837\u6591\u5757\u5bc6\u5ea6\uff0c\u91c7\u7528NIA-AA\u795e\u7ecf\u75c5\u7406\u6027\u6807\u51c6\u8bc4\u4f30\uff09\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u654f\u611f\u6027\u548c\u7279\u5f02\u6027\u3002<\/span><\/p>\n

BMS-986165<\/strong><\/span><\/p>\n

BMS-986165\u662f\u4e00\u79cd\u65b0\u578b\u53e3\u670d\u9009\u62e9\u6027TYK2\u6291\u5236\u5242\uff0c\u8be5\u836f\u6240\u5177\u6709\u7684\u72ec\u7279\u4f5c\u7528\u673a\u5236\u6709\u671b\u63d0\u4f9b\u4e00\u79cd\u6709\u524d\u666f\u7684\u53e3\u670d\u9009\u62e9\uff0c\u5e2e\u52a9\u60a3\u8005\u6709\u6548\u63a7\u5236\u5176\u94f6\u5c51\u75c5\u3002\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u8fd1\u65e5\u516c\u5e03\u4e86\u5b9e\u9a8c\u6027\u6297\u708e\u836fBMS-986165\u6cbb\u7597\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u6591\u5757\u578b\u94f6\u5c51\u75c5\u7684II\u671f\u4e34\u5e8a\u7814\u7a76IM011-011\u7684\u79ef\u6781\u6570\u636e\u3002<\/span><\/p>\n

\u8be5\u7814\u7a76\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u5e73\u884c\u7ec4\u7814\u7a76\uff0c\u5728\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u6591\u5757\u578b\u94f6\u5c51\u75c5\u6210\u4eba\u60a3\u8005\u4e2d\u5f00\u5c55\uff0c\u65e8\u5728\u8bc4\u4f30BMS-986165\u7684\u4e34\u5e8a\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u8be5\u7814\u7a76\u5171\u5165\u7ec4\u4e86267\u4f8b\u60a3\u8005\uff0c\u7814\u7a76\u4e2d\u8fd9\u4e9b\u60a3\u8005\u4ee51:1:1:1:1:1\u7684\u6bd4\u4f8b\u5206\u914d\u81f35\u79cdBMS-986165\u65b9\u6848\u7ec4\uff083mg QOD[\u6bcf\u9694\u4e00\u59293mg\uff0cn=44]\u30013mg QD[\u6bcf\u59293mg\uff0cn=44]\u30013mg BID[\u6bcf\u59292\u6b213mg\uff0cn=45]\u30016mg QD[\u6bcf\u59292\u6b216mg\uff0cn=45]\u300112mg QD[\u6bcf\u592912mg\uff0cn=44]\uff09\u6216\u5b89\u6170\u5242\u7ec4\uff08n=45\uff09\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u6cbb\u7597\u7b2c12\u5468\u5b9e\u73b0PASI75\u7684\u60a3\u8005\u6bd4\u4f8b\uff0c\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u5305\u62ecPASI90\u3001PASI100\u3001\u76ae\u80a4\u75c5\u751f\u6d3b\u8d28\u91cf\u6307\u6570\uff08DLQI\uff09\u3002<\/span><\/p>\n

\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5728\u6cbb\u7597\u7684\u7b2c12\u5468\uff0c3mg BID\u53ca\u66f4\u9ad8\u5242\u91cfBMS-986165\u6cbb\u7597\u7ec4\u5b9e\u73b0PASI75\u7684\u60a3\u8005\u6bd4\u4f8b\u572867%-75%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a7%\u3002\u5177\u4f53\u800c\u8a00\uff0c\u5b9e\u73b0PASI75\u7684\u60a3\u8005\u6bd4\u4f8b\uff1a\u5b89\u6170\u5242\u7ec47%\u30013mgQOD\u4e3a9%\uff08p=0.49\uff09\u30013mgQD\u4e3a39%\uff08p\uff1c0.001\uff09\u30013mgBID\u4e3a69%\uff08p\uff1c0.001\uff09\u30016mgBID\u4e3a67%\uff08p\uff1c0.001\uff09\u300112mgQD\u4e3a75%\uff08p\uff1c0.001\uff09\u3002\u6240\u89c2\u5bdf\u5230\u7597\u6548\u4e0e\u60a3\u8005\u5148\u524d\u662f\u5426\u63a5\u53d7\u8fc7\u751f\u7269\u7597\u6cd5\u65e0\u5173\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ecPASI90\uff08\u5206\u522b\u4e3a\uff1a2%\u30017%\u300116%\u300144%\u300144%\u300143%\uff09\u548cPASI100\uff08\u5206\u522b\u4e3a0%\u30012%\u30010%\u30019%\u300118%\u300125%\uff09\u3002\u9759\u6001\u533b\u5e08\u5168\u9762\u8bc4\u4f30\uff08sPGA\uff09\u8bc4\u5206\u4e3a0\uff08\u6e05\u6670\uff09\u62161\uff08\u5fae\u5c0f\u75be\u75c5\uff09\u65b9\u9762\uff0c3mgBID\u53ca\u66f4\u9ad8\u5242\u91cfBMS-986165\u6cbb\u7597\u7ec4\u7684\u60a3\u8005\u6bd4\u4f8b\u572864%-76%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a7%\u3002DLQI\u8bc4\u5206\u4e3a0\u62161\u65b9\u9762\uff0c3mgBID\u30016mgBID\u300112mgQD\u6cbb\u7597\u7ec4\u5206\u522b\u4e3a42%\u300160%\u300164%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a4%\u3002\u5b89\u5168\u6027\u65b9\u9762\uff0cBMS-986165\u6cbb\u7597\u7ec4\u53d1\u751f3\u4f8b\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5b89\u6170\u5242\u7ec4\u53d1\u751f2\u4f8b\u3002BMS-986165\u6700\u9ad8\u5242\u91cf\u7ec4\uff086mgBID\u548c12mgQD\uff09\u6ca1\u6709\u53d1\u751f\u4e25\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002BMS-986165\u6cbb\u7597\u7ec4\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u4e3a55%-80%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a51%\u3002\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u9f3b\u54bd\u708e\u3001\u5934\u75db\u3001\u8179\u6cfb\u3001\u6076\u5fc3\u548c\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3002<\/span><\/p>\n

BMS-986165\u662f\u4e00\u79cd\u65b0\u578b\u3001\u53e3\u670d\u3001\u9009\u62e9\u6027TYK2\u6291\u5236\u5242\uff0c\u5176\u72ec\u7279\u7684\u4f5c\u7528\u673a\u5236\u4e0d\u540c\u4e8e\u5176\u4ed6\u6fc0\u9176\u6291\u5236\u5242\u3002\u76ee\u524d\uff0c\u8bc4\u4f30\u8be5\u836f\u6cbb\u7597\u6591\u5757\u578b\u94f6\u5c51\u75c5\u7684\u2162\u671f\u4e34\u5e8a\u9879\u76ee\u6b63\u5728\u62db\u52df\u60a3\u8005\uff0c\u8bc4\u4f30\u8be5\u836f\u6cbb\u7597\u5176\u4ed6\u514d\u75ab\u4ecb\u5bfc\u6027\u75be\u75c5\u5982\u72fc\u75ae\u548c\u514b\u7f57\u6069\u75c5\u6b63\u5904\u4e8e\u2161\u671f\u4e34\u5e8a\u3002<\/span><\/p>\n

Filgotinib<\/strong><\/span><\/p>\n

Filgotinib\u662f\u4e00\u79cd\u9009\u62e9\u6027JAK1\u6291\u5236\u5242\uff0c\u53ef\u7528\u4e8e\u591a\u79cd\u708e\u75c7\u6027\u75be\u75c5\u7684\u6cbb\u7597\u3002\u8fd1\u65e5\uff0c\u5409\u5229\u5fb7\u79d1\u5b66\u4e0eGalapagos\u5ba3\u5e03\uff0cfilgotinib\u5728\u6cbb\u7597\u4e2d\u91cd\u5ea6\u6d3b\u52a8\u6027\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff08RA\uff09\u7684\u4e34\u5e8a\u2162\u671f\u8bd5\u9a8c\u4e2d\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u53ca\u6240\u6709\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u3002<\/span><\/p>\n

FINCH 2\u662f\u4e00\u9879\u4e3a\u671f24\u5468\u7684\u5168\u7403\u6027\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u76843\u671f\u7814\u7a76\uff0c\u5728\u4e2d\u91cd\u5ea6\u6d3b\u52a8\u6027\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u60a3\u8005\u4e2d\uff0c\u8bc4\u4f30filgotinib\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u8fd9\u4e9b\u60a3\u8005\u540c\u65f6\u670d\u7528\u5e38\u89c4\u5408\u6210\u6539\u5584\u75c5\u60c5\u6297\u98ce\u6e7f\u836f\uff08csDMARDs\uff09\u3002\u4ed6\u4eec\u5bf9\u751f\u7269\u5236\u5242\u7c7bDMARDs\uff08bDMARDs\uff09\u53cd\u5e94\u4e0d\u4f73\uff0c\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c23.7\uff05\u7684\u60a3\u8005\u63a5\u53d7\u8fc7\u4e09\u79cd\u6216\u66f4\u591a\u79cdbDMARDs\u7684\u6cbb\u7597\u3002\u6240\u6709\u60a3\u8005\u88ab\u968f\u673a\uff081\uff1a1\uff1a1\uff09\u5206\u914d\u63a5\u53d7filgotinib 100 mg\u3001filgotinib 200 mg\u6216\u5b89\u6170\u5242\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u5728\u7b2c12\u5468\u8fbe\u5230\u7f8e\u56fd\u98ce\u6e7f\u75c5\u5b66\u4f1a20\uff05\u7f13\u89e3\uff08ACR20\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u7814\u7a76\u8fbe\u5230\u4e86\u5176\u4e3b\u8981\u7ec8\u70b9\u3002\u5e76\u4e14\u5728\u7b2c12\u5468\u548c\u7b2c24\u5468\uff0c\u6cbb\u7597\u7ec4\u8fbe\u5230ACR50\u548cACR70\u3001\u4f4e\u75be\u75c5\u6d3b\u52a8\uff08LDA\uff0cDAS28\uff08CRP\uff09\u22643.2\uff09\u548c\u4e34\u5e8a\u7f13\u89e3\uff08DAS28\uff08CRP\uff09<2.6\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\u663e\u8457\u9ad8\u4e8e\u5b89\u6170\u5242\u7ec4\u3002\u6b64\u5916\uff0cfilgotinib\u5728\u7814\u7a76\u4e2d\u8868\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e0e\u4e4b\u524d\u7684\u8bd5\u9a8c\u76f8\u6bd4\u6ca1\u6709\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u56e0\u6cbb\u7597\u5f15\u8d77\u7684\u4e0d\u826f\u4e8b\u4ef6\u548c\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7684\u4e25\u91cd\u7a0b\u5ea6\u5927\u591a\u4e3a\u8f7b\u5ea6\u6216\u4e2d\u5ea6\u3002Gilead\u62ab\u9732filgotinib\u7528\u4e8eRA\u7684\u5173\u952eIII\u671f\u6570\u636e\u603b\u4f53\u800c\u8a00\uff0c\u6cbb\u7597\u6548\u679c\u7c7b\u4f3c\u4e8e\u827e\u4f2f\u7ef4\u7684upadacitinib\u4f18\u4e8e\u8f89\u745e\u7684Xeljanz\u53ca\u793c\u6765\u7684olumiant\uff0c\u540c\u65f6\u5b89\u5168\u6027\u6709\u671b\u6700\u4f73\u3002<\/span><\/p>\n


<\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982\u89c8\"<\/section>\n
\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982\u89c8\"<\/section>\n
\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982\u89c8\"<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\u4e34\u5e8a\u8bd5\u9a8c\u79ef\u6781\u8fdb\u5c55\u4e0d\u4f73\u4e8b\u4ef6<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u5728\u68c0\u7d22\u65f6\u95f4\u5185\uff0c\u670938\u4e2a\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u4e0d\u7406\u60f3\u3001\u751a\u81f3\u6682\u505c\u7814\u53d1\uff08\u88682\uff09\uff0c\u4e0b\u9762\u5bf9\u90e8\u5206\u836f\u7269\u7684\u91cd\u8981\u4e34\u5e8a\u8bd5\u9a8c\u60c5\u51b5\u8fdb\u884c\u4ecb\u7ecd\u3002<\/span>
<\/p>\n

\u88682\uff1a2018\u5e748\u670810\u65e5\uff5e2018\u5e749\u670813\u65e5\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u4e0d\u4f73\u7684\u836f\u7269<\/span><\/p>\n

\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982\u89c8\"<\/p>\n

\u6ce8\uff1a\u5176\u4e2d\u5bf9\u7ea2\u8272\u6807\u6ce8\u7684\u836f\u7269\u4f5c\u91cd\u70b9\u4ecb\u7ecd<\/span><\/p>\n

Gemcabene<\/strong><\/span><\/p>\n

Gemcabene\u662f\u7531Gemphire\u516c\u53f8\u5f00\u53d1\u7684first-in-class\u3001\u6bcf\u65e5\u4e00\u6b21\u7684\u53e3\u670d\u7597\u6cd5\uff0c\u53ef\u80fd\u9002\u7528\u4e8e\u91c7\u7528\u76ee\u524d\u5df2\u6279\u51c6\u7597\u6cd5\uff08\u4e3b\u8981\u662f\u4ed6\u6c40\u7c7b\u836f\u7269\uff09\u4f46\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\uff08LDL-C\uff09\u6216TG\u4ecd\u65e0\u6cd5\u8fbe\u5230\u6b63\u5e38\u6c34\u5e73\u7684\u60a3\u8005\u3002Gemcabene\u65e8\u5728\u63d0\u9ad8\u8840\u6d46\u4e2dVLDL\u7684\u6e05\u9664\u7387\uff0c\u5e76\u6291\u5236\u809d\u810f\u4e2d\u80c6\u56fa\u9187\u548cTG\u7684\u4ea7\u751f\u3002<\/span><\/p>\n

2018\u5e748\u670810\u65e5\uff0cGemphire Therapeutics\u5ba3\u5e03\u7ec8\u6b62\u5176Gemcabene\u7684\u513f\u7ae5\u6027NAFLD\u4e34\u5e8aIIa\u671f\u7814\u7a76\uff0c\u7531\u4e8e\u6700\u65e9\u63a5\u53d7Gemcabene\u6cbb\u7597\u76843\u540d\u60a3\u8005\u7684\u809d\u810f\u8102\u80aa\u6c34\u5e73\u6709\u6240\u589e\u52a0\uff0c\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u8fd9\u4e0eGemcabene\u6709\u5173\u5e76\u5bf9\u60a3\u8005\u5b89\u5168\u4ea7\u751f\u98ce\u9669\uff0cGemcabene\u5728\u6210\u4eba\u4e0e\u513f\u7ae5\u4e2d\u7684\u8868\u73b0\u76f8\u5dee\u5f88\u5927\u3002\u6b64\u5916\uff0c8\u67088\u65e5Gemphire\u8868\u793aFDA\u4e0d\u540c\u610f\u5176\u5f00\u5c55Gemcabene\u8fdb\u4e00\u6b65\u7684\u957f\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u76f4\u5230\u5b89\u5168\u6027\u6570\u636e\u5ba1\u67e5\u7ed3\u675f\u3002<\/span><\/p>\n

\u5728\u6b64\u4e4b\u524d\uff0cGemphire Therapeutics\u516c\u5e03gemcabene\u5df2\u7ecf\u62b5\u8fbe\u2161b\u671f\u4e34\u5e8a\u8bd5\u9a8cINDIGO-1\u7684\u4e3b\u8981\u7ec8\u70b9\uff0c\u80fd\u964d\u4f4e\u57fa\u7ebf\u8840\u6e05\u7518\u6cb9\u4e09\u916f\uff08TG\uff09>500mg\/dL\u7684\u4e25\u91cd\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\uff08SHTG\uff09\u60a3\u8005\u7684TG\u3002<\/span><\/p>\n

PF-06252616<\/strong><\/span><\/p>\n

PF-06252616\uff08domagrozumab\uff09\u662f\u4e00\u79cd\u5355\u514b\u9686\u6297\u4f53\u836f\u7269\uff0c\u9776\u5411\u808c\u8089\u751f\u957f\u6291\u7d20\uff0c\u8fd9\u662f\u4e00\u79cd\u5728\u4eba\u4f53\u7684\u808c\u8089\u4e2d\u81ea\u7136\u5b58\u5728\u7684\u86cb\u767d\u8d28\uff0c\u8d77\u5230\u63a7\u5236\u808c\u8089\u8fc7\u5ea6\u751f\u957f\u7684\u4f5c\u7528\u3002\u8be5\u836f\u65e8\u5728\u6291\u5236\u808c\u8089\u751f\u957f\u6291\u7d20\uff0c\u4ee5\u589e\u52a0DMD\u7b49\u808c\u8089\u840e\u7f29\u75c7\u60a3\u8005\u7684\u808c\u8089\u4f53\u79ef\uff0c\u4ece\u800c\u8d77\u5230\u6cbb\u7597\u7684\u4f5c\u7528\u3002\u8f89\u745e\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5c06\u7ec8\u6b62PF-06252616\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u6b63\u5728\u8fdb\u884c\u4e2d\u7684\u4e24\u9879\u4e34\u5e8a\u7814\u7a76\uff1a\u4e00\u9879II\u671f\u5b89\u5168\u548c\u6709\u6548\u6027\u7814\u7a76\uff08B5161002\uff09\u548c\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u6269\u5c55\u7814\u7a76\uff08B5161004\uff09\u3002<\/span><\/p>\n

B5161002\u662f\u4e00\u98792\u5e74\u671f\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\uff0c\u5728121\u4f8b6-15\u5c81DMD\u7537\u5b69\uff08\u4e0d\u8bba\u5176\u6f5c\u5728\u57fa\u56e0\u7a81\u53d8\u60c5\u51b5\u5982\u4f55\uff09\u4e2d\u5f00\u5c55\uff0c\u65e8\u5728\u8bc4\u4f30\u6bcf\u6708\u4e00\u6b21\u9759\u8109\u8f93\u6ce8PF-06252616\u76f8\u5bf9\u4e8e\u5b89\u6170\u5242\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u4e3b\u8981\u5206\u6790\u5728\u6cbb\u7597\u4e00\u5e74\u540e\u5f00\u5c55\u3002B5161004\u5f00\u653e\u6807\u7b7e\u7814\u7a76\u65e8\u5728\u8bc4\u4f30PF-06252616\u7684\u957f\u671f\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u524d\u8005\u6570\u636e\u663e\u793a\uff0c\u63a5\u53d7\u4e00\u5e74\u6cbb\u7597\u540e\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0cPF-06252616\u6cbb\u7597\u7ec4\u57284\u7ea7\u722c\u697c\u68af\u6d4b\u8bd5\u4e2d\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u7684\u5e73\u5747\u53d8\u5316\u5e76\u6ca1\u6709\u8868\u73b0\u51fa\u5dee\u5f02\uff0c\u6ca1\u6709\u8fbe\u5230\u7814\u7a76\u7684\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\uff1b\u6b64\u5916\uff0c\u5bf9\u5305\u62ec\u6b21\u8981\u7ec8\u70b9\u5728\u5185\u603b\u4f53\u8bc1\u636e\u7684\u8fdb\u4e00\u6b65\u8bc4\u4f30\u4e5f\u4e0d\u652f\u6301\u836f\u7269\u5177\u6709\u663e\u8457\u7684\u6cbb\u7597\u6548\u679c\u3002<\/span><\/p>\n

\u8f89\u745e\u8868\u793a\uff0c\u6b64\u6b21\u51b3\u5b9a\u662f\u57fa\u4e8e\u4e3b\u8981\u5206\u6790\u65f6\u5bf9\u6240\u6709\u53ef\u7528\u6570\u636e\u8fdb\u884c\u5f7b\u5e95\u5ba1\u67e5\u4e4b\u540e\u505a\u51fa\u7684\uff0c\u5206\u6790\u5305\u62ec\u6cbb\u7597\u4e00\u5e74\u540e\u7684\u6240\u6709\u7814\u7a76\u53d7\u8bd5\u8005\u3002\u7814\u7a76\u7ec8\u6b62\u5e76\u975e\u7531\u4e8e\u5b89\u5168\u6027\u539f\u56e0\uff0c\u8f89\u745e\u5c06\u7ee7\u7eed\u5ba1\u67e5\u8fd9\u4e9b\u6570\u636e\uff0c\u4ee5\u4fbf\u66f4\u597d\u5730\u7406\u89e3\u5176\u53ef\u80fd\u63d0\u4f9b\u7684\u4efb\u4f55\u89c1\u89e3\uff0c\u5e76\u5c06\u4e0e\u79d1\u5b66\u754c\u548c\u60a3\u8005\u754c\u5206\u4eab\u76f8\u5173\u7ed3\u679c\u3002\u5c3d\u7ba1\u51b3\u5b9a\u7ec8\u6b62domagrozumab\u4e34\u5e8a\u5f00\u53d1\uff0c\u4f46\u8f89\u745e\u4ecd\u5728\u7ee7\u7eed\u63a8\u8fdbDMD\u548c\u7f55\u89c1\u795e\u7ecf\u808c\u8089\u75be\u75c5\u9886\u57df\u7684\u7814\u7a76\uff0c\u5176\u4e2d\u5305\u62ec\u4e00\u6b3e\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u57fa\u56e0\u7597\u6cd5PF-06939926\u3002<\/span><\/p>\n

Anifrolumab<\/strong><\/span><\/p>\n

Anifrolumab\u662f\u4e00\u79cd\u9776\u5411I\u578b\u5e72\u6270\u7d20\u53d7\u4f53\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u4e2d\u5ea6\u5230\u91cd\u5ea6\u7cfb\u7edf\u7cfb\u6027\u7ea2\u6591\u72fc\u75ae\u3002\u963f\u65af\u5229\u5eb7\u8fd1\u65e5\u5ba3\u5e03\uff0c\u8be5\u836f\u7684\u4e34\u5e8a\u2162\u671f\u7814\u7a76\u672a\u80fd\u5230\u8fbe\u75be\u75c5\u6d3b\u52a8\u663e\u7740\u964d\u4f4e\u7684\u4e3b\u8981\u7ec8\u70b9\u3002<\/span><\/p>\n

\u76ee\u524d\u5e02\u573a\u4e0a\u53ef\u9009\u62e9\u7684\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u836f\u7269\u5f88\u5c11\uff0c\u5728\u6b64\u4e4b\u524d\uff0c\u963f\u65af\u5229\u5eb7\u62a5\u9053anifrolumab\uff08\u4ee5\u524d\u79f0\u4e3aMEDI-546\uff09\u5230\u8fbe\u5176II\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u548c\u6b21\u8981\u76ee\u6807\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u5728\u591a\u4e2a\u7ec8\u70b9\u4e0a\u663e\u7740\u964d\u4f4e\u72fc\u75ae\u75be\u75c5\u6d3b\u52a8\u3002<\/span><\/p>\n

Dasotraline<\/strong><\/span><\/p>\n

Dasotraline\u662f\u4e00\u79cd\u65b0\u578b\u7684\u5177\u6709\u53cc\u91cd\u9776\u5411\u4f5c\u7528\u7684\u591a\u5df4\u80fa\u548c\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u518d\u6444\u53d6\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u6ce8\u610f\u529b\u7f3a\u9677\u591a\u52a8\u969c\u788d\uff08ADHD\uff09\uff0c\u4e5f\u6b63\u5728\u88ab\u7814\u7a76\u7528\u4e8e\u6cbb\u7597\u7f8e\u56fd\u6210\u5e74\u4eba\u7684\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u66b4\u98df\u75c7\uff08BED\uff09\u3002<\/span><\/p>\n

\u6cbb\u7597ADHD\u4e34\u5e8a\u7814\u7a76\u5bf9\u7ea62500\u540d\u60a3\u6709ADHD\u7684\u513f\u7ae5\u548c\u6210\u4eba\u53d7\u8bd5\u3001\u6709\u591a\u7ec4\u5b89\u6170\u5242\u5bf9\u7167\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7814\u7a761\u30012\u30013\u30014\u4ee5\u53ca\u4e24\u4e2a\u957f\u671f\u5b89\u5168\u6027\u7814\u7a76\u4e2d\u5bf9dasotraline\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002Sunovion\u5236\u836f\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u53d1\u5e03\u4e86\u4e00\u4efd\u5173\u4e8e\u51762017\u5e7411\u6708\u4efd\u7533\u8bf7\u7684\u5316\u5b66\u65b0\u836fdasotraline\u7684\u5b8c\u6574\u56de\u5e94\u4fe1\uff0cFDA\u5b8c\u6210\u5ba1\u8bc4\u540e\uff0c\u51b3\u5b9a\u4e0d\u4e88\u4ee5\u6279\u51c6\uff0c\u5ba1\u8bc4\u673a\u6784\u6307\u51fa\uff0c\u9700\u8981\u66f4\u591a\u7684\u4e34\u5e8a\u6570\u636e\u6765\u8fdb\u4e00\u6b65\u8bc4\u4f30dasotraline\u7684\u7597\u6548\u548c\u8010\u53d7\u6027\u3002Sunovion\u8ba1\u5212\u4e0eFDA\u4f1a\u9762\uff0c\u8ba8\u8bba\u4ed6\u4eec\u7684\u610f\u89c1\u5e76\u51b3\u5b9a\u4e0b\u4e00\u6b65\u7684\u884c\u52a8\u3002<\/span><\/p>\n

Nucala<\/strong><\/span><\/p>\n

2018\u5e749\u67087\u65e5\uff0c\u845b\u5170\u7d20\u53f2\u514b\uff08GSK\uff09\u53d1\u8868\u58f0\u660e\uff1aFDA\u62d2\u7eddNucala\u4f5c\u4e3a\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\uff08COPD\uff09\u7684\u9644\u52a0\u6cbb\u7597\uff0cFDA\u8ba4\u4e3a\u7f3a\u4e4f\u8db3\u591f\u7684\u6570\u636e\u8bc1\u660eNucala\u7684\u7597\u6548\u4ee5\u53ca\u8868\u5f81\u6700\u6709\u53ef\u80fd\u4ece\u8fd9\u79cd\u9776\u5411\u751f\u7269\u7597\u6cd5\u4e2d\u53d7\u76ca\u7684\u60a3\u8005\u7fa4\u4f53\u3002<\/span><\/p>\n

2017\u5e7411\u6708\uff0cGSK\u5411FDA\u9012\u4ea4\u4e86Nucala\u4f5c\u4e3a\u5438\u5165\u6027\u76ae\u8d28\u7c7b\u56fa\u9187\u7ef4\u6301\u65b9\u6848\u7684\u9644\u52a0\u7597\u6cd5\u6cbb\u7597\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u6027COPD\u7684\u65b0\u9002\u5e94\u75c7\u7533\u8bf7\uff0c\u5176sBLA\u7684\u6570\u636e\u4f9d\u636e\u662f\u4e24\u9879\u4e34\u5e8aIII\u671f\u7814\u7a76\uff1aMEA117106\u548cMEA117113\uff0c\u5176\u4e3b\u8981\u7ec8\u70b9\u5747\u4e3a52\u5468\u4e2d\u91cd\u5ea6COPD\u6076\u5316\u7684\u53d1\u751f\u7387\u3002<\/span><\/p>\n

2108\u5e747\u6708\uff0cFDA\u80ba\u53d8\u6001\u53cd\u5e94\u836f\u7269\u54a8\u8be2\u59d4\u5458\u4f1a\uff08PADAC\uff09\u5bf9GSK\u9012\u4ea4\u7684\u6570\u636e\u8fdb\u884c\u4e86\u8ba8\u8bba\uff0c\u4ee53\u7968\u8d5e\u6210\u300116\u7968\u53cd\u5bf9\u7684\u6295\u7968\u7ed3\u679c\u8ba4\u4e3aNucala\u7684\u98ce\u9669\u6548\u76ca\u4e0d\u8db3\u4ee5\u652f\u6301\u5176\u6279\u51c6\uff0cPADAC\u5efa\u8baeGSK\u63d0\u4f9b\u8fdb\u4e00\u6b65\u7684\u6570\u636e\u6765\u8868\u5f81\u6700\u6709\u53ef\u80fd\u4ece\u8fd9\u79cd\u9776\u5411\u751f\u7269\u7597\u6cd5\u4e2d\u53d7\u76ca\u7684\u60a3\u8005\u7fa4\u4f53\u3002<\/span><\/p>\n

\u5728\u4ec5\u6709\u7684\u4e24\u9879III\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0cMEA117106\u62b5\u8fbe\u4e3b\u8981\u7ec8\u70b9\uff0c\u800cMEA117113\u5e76\u6ca1\u6709\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u3002PADAC\u63d0\u5230\uff0c\u5bf9\u4e8e\u67d0\u4e9b\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff0c\u4f8b\u5982\u53d1\u751f\u9996\u6b21\u4e2d\u5ea6\u81f3\u91cd\u5ea6COPD\u6025\u6027\u52a0\u91cd\u7684\u65f6\u95f4\u5728\u6570\u503c\u4e0a\u4ec5\u663e\u793a\u51fa\u6709\u5229\u4e8eNucala\u7684\u8d8b\u52bf\uff0c\u7136\u800c\u5728\u91cd\u5ea6COPD\u6025\u6027\u52a0\u91cd\u7387\u3001FEV1\u3001SGRQ\u65b9\u9762\uff0c100mg\u5242\u91cfNucala\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u5e76\u6ca1\u6709\u8868\u73b0\u51fa\u4e00\u81f4\u7684\u4e34\u5e8a\u610f\u4e49\u4e0a\u7684\u5dee\u5f02\u3002<\/span><\/p>\n

2018\u5e749\u67087\u65e5\uff0c\u5728\u4e00\u4efd\u7b80\u77ed\u7684\u58f0\u660e\u4e2dGSK\u5ba3\u5e03\u201c\u8be5\u5b8c\u6574\u7b54\u590d\u51fd\u8868\u660e\u9700\u8981\u66f4\u591a\u7684\u4e34\u5e8a\u6570\u636e\u4ee5\u652f\u6301Nucala\u7684\u7533\u8bf7\uff0cGSK\u5c06\u4f1a\u4e0eFDA\u7d27\u5bc6\u5408\u4f5c\u51b3\u5b9asBLA\u7684\u4e0b\u4e00\u6b65\u65b9\u5411\u3002\u201d\u4e5f\u5c31\u662f\u8bf4\uff0cFDA\u6b63\u5f0f\u62d2\u7eddNucala\u4f5c\u4e3aCOPD\u9644\u52a0\u6cbb\u7597\u7684\u7533\u8bf7\uff0c\u8ba4\u4e3a\u7f3a\u4e4f\u8db3\u591f\u7684\u6570\u636e\u8bc1\u660eNucala\u7684\u7597\u6548\u4ee5\u53ca\u8868\u5f81\u6700\u6709\u53ef\u80fd\u4ece\u8fd9\u79cd\u9776\u5411\u751f\u7269\u7597\u6cd5\u4e2d\u53d7\u76ca\u7684\u60a3\u8005\u7fa4\u4f53\u3002<\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982\u89c8\"<\/section>\n
\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982\u89c8\"<\/section>\n
\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982\u89c8\"<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\u9996\u6b21\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u7814\u53d1\u4e8b\u4ef6<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u5728\u68c0\u7d22\u65f6\u95f4\u5185\uff0c\u5171\u670954\u4e2a\u836f\u7269\uff08\u9002\u5e94\u75c7\uff09\u9996\u6b21\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u7edd\u5927\u591a\u6570\u4e3a\u80bf\u7624\u6cbb\u7597\u9886\u57df\u65b0\u836f\uff0c\u670933\u4e2a\uff0c\u8be6\u60c5\u89c1\u88683\u3002<\/span><\/p>\n

\u88683\uff1a2018\u5e748\u670810\u65e5\uff5e2018\u5e749\u670813\u65e5\u9996\u6b21\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u7684\u836f\u7269<\/span><\/p>\n

\n

\u3010\u53c2\u8003\u8d44\u6599\u3011<\/span>
<\/p>\n

1. Informa\u6570\u636e\u5e93, \u68c0\u7d22\u65e5\u671f: 2018\u5e749\u670826\u65e5.<\/span><\/p>\n

2. Clarivate Analytics Integrity\u6570\u636e\u5e93, \u68c0\u7d22\u65e5\u671f: 2018\u5e749\u670825\u65e5.<\/span><\/p>\n

3. \u5176\u5b83\u7f51\u7edc\u516c\u5f00\u53ef\u83b7\u53d6\u8d44\u6e90.<\/span><\/p>\n


<\/p>\n

\n
\n
\n
<\/section>\n
\n
<\/section>\n
<\/section>\n
<\/section>\n<\/section>\n<\/section>\n
\n
\n

\u7248\u6743\u58f0\u660e<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u6587\u4e2d\u6240\u8ff0\u4ec5\u4ee3\u8868\u5176\u4e2a\u4eba\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u516c\u4f17\u53f7\u89c2\u70b9\u3002<\/span><\/strong>\u6b22\u8fce\u4e2a\u4eba\u3001\u7f51\u7ad9\u3001\u516c\u4f17\u53f7\u7b49\u5f15\u7528\u3001\u8f6c\u8f7d\u548c\u5206\u4eab\u3002\u975e\u4e2a\u4eba\u8f6c\u8f7d\u6216\u5f15\u7528\u672c\u7f51\u7248\u6743\u6240\u6709\u5185\u5bb9\u987b\u83b7\u5f97\u6388\u6743\u5e76\u5728\u9192\u76ee\u5904\u6ce8\u660e\u201c\u8f6c\u81ea\uff1a\u521b\u836f\u7f51\u201d\u3002\u6b22\u8fce\u5408\u4f5c\uff0c\u8bf7\u8054\u7cfbiddds@simm.ac.cn\u3002<\/span><\/strong><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u672c\u6587\u4f9d\u636eInforma\u6570\u636e\u5e93\u68b3\u7406\u4e86\u8fd1\u4e00\u4e2a\u6708\uff082018\u5e748\u670810\u65e5\uff5e2018\u5e749\u670813\u65e5\uff09\u5728\u7814\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u6982 […]<\/p>\n","protected":false},"author":1,"featured_media":52653,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/52652"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=52652"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/52652\/revisions"}],"predecessor-version":[{"id":52665,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/52652\/revisions\/52665"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/52653"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=52652"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=52652"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=52652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}