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#ffffff;box-sizing: border-box;\">\n<section style=\"margin: -5px 0% 5px;box-sizing: border-box;transform: translate3d(-5px, 0px, 0px);-webkit-transform: translate3d(-5px, 0px, 0px);-moz-transform: translate3d(-5px, 0px, 0px);-ms-transform: translate3d(-5px, 0px, 0px);-o-transform: translate3d(-5px, 0px, 0px);\">\n<section style=\"display: inline-block;vertical-align: top;border-style: dashed;border-width: 1px;border-radius: 0px;border-color: #6cabae;padding:5px 10px 5px 10px;letter-spacing: 0px;background-color: #feffff;box-sizing: border-box;\">\n<section style=\"margin-top: 5px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"color: #6cabae;font-size: 18px;line-height: 1.1;letter-spacing: 2px;box-sizing: border-box;\">\n<p style=\"margin-bottom: 10px;box-sizing: border-box;\"><strong>\u8fd1\u671f\u83b7\u6279\u7684\u6297\u80bf\u76241\u7c7b\u65b0\u836f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u5c3d\u7ba1\u6211\u56fd\u7684\u56fd\u4ea7\u6297\u80bf\u7624\u836f\u7269\u4f9d\u7136\u4ee5\u4eff\u5236\u836f\u4e3a\u4e3b\uff0c\u4e0d\u8fc7\u968f\u7740\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u81ea\u4e3b\u7814\u53d1\u578b\u521b\u65b0\u836f\u7269\u9010\u6e10\u589e\u591a\u3002\u4ee5\u6c5f\u82cf\u6052\u745e\u4e3a\u4ee3\u8868\u7684\u521b\u65b0\u836f\u7269\u7814\u53d1\u4f01\u4e1a\u9010\u6e10\u4e0e\u56fd\u9645\u63a5\u8f68\uff0c\u5c24\u5176\u662f\u5728\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u9886\u57df\u53d6\u5f97\u4e86\u4f18\u5f02\u7684\u6210\u679c\u3002\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u65b0\u836f\u57c3\u514b\u66ff\u5c3c\uff082011\u5e74\u83b7\u6279\uff09\u3001\u80c3\u764c\u65b0\u836f\u963f\u5e15\u66ff\u5c3c\uff082014\u5e74\u83b7\u6279\uff09\u3001\u4ee5\u53ca\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\u6cbb\u7597\u836f\u7269\u897f\u8fbe\u672c\u80fa\uff082014\u5e74\u83b7\u6279\uff09\u90fd\u4e3a\u6211\u56fd\u764c\u75c7\u60a3\u8005\u5e26\u6765\u4e86\u798f\u97f3\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u65f6\u96944\u5e74\u4e4b\u540e\uff0c2018\u5e74\u6211\u56fd\u836f\u4f01\u81ea\u4e3b\u7814\u53d1\u76841\u7c7b\u6297\u80bf\u7624\u65b0\u836f\u7ec8\u4e8e\u53c8\u8fce\u6765\u91cd\u5927\u8fdb\u5c55\uff0c3\u4e2a\u66ff\u5c3c\u7c7b\u5c0f\u5206\u5b50\u6297\u80bf\u76241\u7c7b\u65b0\u836f\u6b63\u5f0f\u83b7\u6279\u4e0a\u5e02\uff0c\u5206\u522b\u4e3a\u6b63\u5927\u5929\u6674\u7684\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c\u3001\u6052\u745e\u7684\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\u4ee5\u53ca\u548c\u8bb0\u9ec4\u57d4\u7684\u544b\u55b9\u66ff\u5c3c\uff08\u88682\uff09\u3002<\/span><br  \/><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u88682\uff1a2018\u5e74\u83b7\u6279\u4e0a\u5e02\u7684\u56fd\u4ea7\u6297\u80bf\u76241\u7c7b\u65b0\u836f<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;\"><img align=\"\" class=\"\"             style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1538271384.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c<\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c\u7531Advenchen Laboratory\u548c\u6b63\u5927\u5929\u6674\u5408\u4f5c\u5f00\u53d1\uff0c\u662f\u4e00\u6b3e\u65b0\u578b\u5c0f\u5206\u5b50\u591a\u9776\u70b9\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u80fd\u591f\u6709\u6548\u6291\u5236VEGFR\u3001PDGFR\uff08\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff09\u3001FGFR\uff08\u7ea4\u7ef4\u6bcd\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff09\u3001c-Kit\u7b49\u6fc0\u9176\uff0c\u5177\u6709\u6297\u80bf\u7624\u8840\u7ba1\u751f\u6210\u548c\u6291\u5236\u80bf\u7624\u751f\u957f\u7684\u4f5c\u7528\u30022018\u5e745\u6708\uff0c\u8be5\u836f\u83b7NMPA\u6279\u51c6\uff0c\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc72\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u51fa\u73b0\u8fdb\u5c55\u6216\u590d\u53d1\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7597\uff08\u56fe1\uff09\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u5b89\u7f57\u66ff\u5c3c\u83b7\u6279\u6cbb\u7597\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff0c\u4e3b\u8981\u4f9d\u636e\u662f\u4e0e\u5b89\u6170\u5242\u5bf9\u7167\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u2162\u671f\u8bd5\u9a8c\uff08NCT02388919\uff0cALTER-0303\uff09\u3002\u8be5\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff1a\u5b89\u7f57\u66ff\u5c3c\u5355\u836f\u80fd\u591f\u663e\u8457\u5ef6\u957f\u4e2d\u4f4d\u603b\u4f53\u751f\u5b58\u671f\uff08OS\uff09\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0cOS\u5ef6\u957f3.3\u4e2a\u6708\uff089.6 vs 6.3\u4e2a\u6708\uff09\uff1bPFS\u5ef6\u957f4.0\u4e2a\u6708\uff085.4 vs 1.4\u4e2a\u6708\uff09\u3002EGFR\u4e9a\u7ec4\u5206\u6790\u663e\u793a\uff0cEGFR\u654f\u611f\u6027\u7a81\u53d8\u9633\u6027\u6216\u9634\u6027\u7684\u60a3\u8005\u90fd\u80fd\u4ece\u5b89\u7f57\u66ff\u5c3c\u7684\u6cbb\u7597\u4e2d\u83b7\u5f97OS\u548cPFS\u7684\u53cc\u91cd\u83b7\u76ca\u3002<\/span><\/p>\n<p style=\"text-align: justify;margin-top: 10px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;line-height: normal;margin-bottom: 5px;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"299\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" width=\"560\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1538271384.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-top: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u56fe1\uff1a\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c\u7684\u7814\u53d1\u91cc\u7a0b\u7891\u4e8b\u4ef6<\/span><\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u8be5\u836f\u76ee\u524d\u5728\u591a\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u5f00\u5c55\u4e34\u5e8a\u7814\u7a76\uff0c\u9664\u4e86\u5df2\u7ecf\u83b7\u6279\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9002\u5e94\u75c7\u4e4b\u5916\uff0c\u9488\u5bf9\u7532\u72b6\u817a\u9ad3\u6837\u764c\u548c\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u6cbb\u7597\u4e5f\u5df2\u7ecf\u5728\u4e2d\u56fd\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u3002\u9488\u5bf9\u8f6f\u7ec4\u7ec7\u8089\u7624\u3001\u5e73\u6ed1\u808c\u8089\u7624\u3001\u80c3\u764c\u7b49\u9002\u5e94\u75c7\u5904\u4e8e\u4e34\u5e8a\u2162\u671f\u7814\u7a76\u9636\u6bb5\uff1b\u9488\u5bf9\u8f93\u5375\u7ba1\u764c\u3001\u5bab\u9888\u764c\u3001\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u3001\u809d\u7ec6\u80de\u764c\u3001\u8179\u819c\u80bf\u7624\u3001\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u3001\u98df\u7ba1\u764c\u3001\u5b50\u5bab\u5185\u819c\u764c\u3001\u5c0f\u7ec6\u80de\u80ba\u764c\u7b49\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u2161\u671f\u7814\u7a76\u4e5f\u5728\u8fdb\u884c\uff08\u88683\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u88683\uff1a\u76d0\u9178\u5b89\u7f57\u66ff\u5c3c\u5728\u7814\u9002\u5e94\u75c7<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><img align=\"\" class=\"\"             style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/2-1538271384.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c<\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\u662f\u6c5f\u82cf\u6052\u745e\u7814\u53d1\u7684\u6cdb-ErbB\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u540c\u65f6\u5177\u6709\u6297EGFR\u3001HER1\u3001HER2\u4ee5\u53caHER4\u6d3b\u6027\u3002\u8be5\u836f\u4e8e2018\u5e748\u670812\u65e5\u83b7\u5f97NMPA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8eHER2\u9633\u6027\u665a\u671f\u4e73\u817a\u764c\u7684\u9776\u5411\u6cbb\u7597\u3002\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\u662f\u57fa\u4e8e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u53d6\u5f97\u7a81\u7834\u6027\u7597\u6548\u88abCDE\u5217\u5165\u4f18\u5148\u5ba1\u8bc4\uff0c\u4ece\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\u5230\u6b63\u5f0f\u83b7\u6279\u4ec5\u5386\u65f61\u5e74\u65f6\u95f4\uff08\u56fe2\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;\"><img align=\"\" class=\"\"             style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1538271385.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u56fe2\uff1a\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\u7684\u7814\u53d1\u91cc\u7a0b\u7891\u4e8b\u4ef6<\/span><\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u6052\u745e\u533b\u836f\u57282015\u5e74\u542f\u52a8\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\u9488\u5bf9HER2\u8868\u8fbe\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u2160\/\u2161\u671f\u8bd5\u9a8c\uff08NCT02422199\u3001CTR20150279\uff09\uff0c\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a\u5728\u9488\u5bf9\u7ecf\u84bd\u73af\u7c7b\u548c\u7d2b\u6749\u7c7b\u836f\u7269\u6cbb\u7597\u5931\u8d25\uff0c\u4e14\u590d\u53d1\/\u8f6c\u79fb\u540e\u5316\u7597\u4e0d\u8d85\u8fc72\u7ebf\u7684\u4e73\u817a\u764c\u60a3\u8005\uff0c\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\u7247\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u7247\uff08ORR\u4e3a78.5%\uff0cmPFS\u4e3a18.1\u4e2a\u6708\uff09\uff0c\u4e0e\u7532\u82ef\u78fa\u9178\u62c9\u5e15\u66ff\u5c3c\u7247\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u7247\uff08ORR\u4e3a 57.1%\uff0cmPFS\u4e3a7.0\u4e2a\u6708\uff09\u76f8\u6bd4\uff0c\u751f\u5b58\u671f\u663e\u8457\u5ef6\u957f\uff0c\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u610f\u4e49\uff08P&lt;0.0001\uff09\uff0c\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u4e0b\u964d63.7%\uff08HR=0.363\uff09\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u5421\u54af\u66ff\u5c3c\u662f\u9776\u5411\u6027\u975e\u5e38\u5f3a\u7684\u836f\uff0c\u53ea\u80fd\u7528\u4e8eHER2\u53d7\u4f53\u9633\u6027\u60a3\u8005\u3002\u4f5c\u4e3a\u6297\u80bf\u7624\u4e2a\u6027\u5316\u836f\u7269\uff0c\u5421\u54af\u66ff\u5c3c\u9488\u5bf9\u7684\u6cbb\u7597\u4eba\u7fa4\u5e76\u4e0d\u7b97\u5e7f\u6cdb\uff0c\u76ee\u524d\u8be5\u836f\u5728\u7814\u7684\u9002\u5e94\u75c7\u8fd8\u5305\u62ecHER2\u9633\u6027\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4ee5\u53caHER2\u9633\u6027\u7684\u665a\u671f\u80c3\u764c\uff08\u88684\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u88684\uff1a\u9a6c\u6765\u9178\u5421\u54af\u66ff\u5c3c\u5728\u7814\u9002\u5e94\u75c7<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><img align=\"\" class=\"\"              style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/3-1538271385.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>\u544b\u55b9\u66ff\u5c3c<\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u544b\u55b9\u66ff\u5c3c\u662f\u55b9\u5511\u5549\u7c7b\u5c0f\u5206\u5b50\u8840\u7ba1\u751f\u6210\u6291\u5236\u5242\uff0c\u4e3b\u8981\u4f5c\u7528\u9776\u70b9\u662fVEGFR\u6fc0\u9176\u5bb6\u65cf\uff08VEGFR1\/2\/3\uff09\u3002\u9ad8\u6548\u3001\u4f4e\u6bd2\u3001\u9002\u5408\u8054\u5408\u7528\u836f\u662f\u544b\u55b9\u66ff\u5c3c\u533a\u522b\u4e8e\u5176\u4ed6\u5df2\u83b7\u6279\u7684\u5c0f\u5206\u5b50VEGFR\u6291\u5236\u5242\u7684\u4f18\u826f\u7279\u6027\u30022013\u5e7410\u6708\uff0c\u548c\u8bb0\u9ec4\u57d4\u6388\u6743\u7ed9\u793c\u6765\u516c\u53f8\u5408\u4f5c\u5f00\u53d1\u544b\u55b9\u66ff\u5c3c\u30022018\u5e749\u6708\uff0cNMPA\u6279\u51c6\u544b\u55b9\u66ff\u5c3c\u80f6\u56ca\u4e0a\u5e02\uff0c\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u7c7b\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u6cbb\u7597\u3001\u6297\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u6cbb\u7597\uff08RAS\u91ce\u751f\u578b\uff09\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff08\u56fe3\uff09\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u544b\u55b9\u66ff\u5c3c\u80f6\u56ca\u4e3a\u5883\u5185\u5916\u5747\u672a\u4e0a\u5e02\u7684\u521b\u65b0\u836f\uff0c\u662f\u7531\u4e2d\u56fd\u672c\u571f\u4f01\u4e1a\u81ea\u4e3b\u7814\u5236\u7684\u3001\u5177\u6709\u5b8c\u5168\u77e5\u8bc6\u4ea7\u6743\u7684\u65b0\u578b\u9776\u5411\u6297\u80bf\u7624\u836f\u7269\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"315\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" width=\"500\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1538271385.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u56fe3\uff1a\u544b\u55b9\u66ff\u5c3c\u7684\u7814\u53d1\u91cc\u7a0b\u7891\u4e8b\u4ef6<\/span><\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">2014\u5e7412\u6708\uff0c\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684\u591a\u4e2d\u5fc3\u7684\u5173\u952e\u6027\u4e34\u5e8aIII\u671f\u7814\u7a76\uff08FRESCO\uff0cNCT02314819\uff09\u5728\u4e2d\u56fd\u542f\u52a8\u3002\u8be5\u7814\u7a76\u4e8e2017\u5e741\u670817\u65e5\u7ed3\u675f\uff0c\u7814\u7a76\u5171\u5165\u7ec4416\u540d\u60a3\u8005\uff0c\u5176\u4e2d404\u540d\u60a3\u8005\u5b8c\u6210\u4e86\u8bd5\u9a8c\u3002\u7814\u7a76\u6210\u529f\u5730\u8fbe\u5230\u4e86\u9884\u8bbe\u7684\u5168\u90e8\u7ec8\u70b9\uff08OS\u4e3a\u4e3b\u8981\u7ec8\u70b9\uff0cPFS\u3001ORR\u4e3a\u6b21\u8981\u7ec8\u70b9\uff09\u3002\u544b\u55b9\u66ff\u5c3c\u7ec4\u60a3\u8005\u7684mOS\u3001mPFS\u5206\u522b\u4e3a9.3\u4e2a\u6708\u4e0e3.7\u4e2a\u6708\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u60a3\u8005\u7684mOS\u3001mPFS\u5206\u522b\u4e3a6.6\u4e2a\u6708\u4e0e1.8\u4e2a\u6708\uff1b\u6b64\u5916\uff0c\u544b\u55b9\u66ff\u5c3c\u7ec4ORR\uff08\u5ba2\u89c2\u7f13\u89e3\u7387\uff09\u548cDCR\uff08\u75be\u75c5\u63a7\u5236\u7387\uff09\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff084.7%\u300162.2% vs 0%\u300112.3%\uff09\uff0c\u964d\u4f4e\u75be\u75c5\u8fdb\u5c55\u98ce\u966974%\u3002\u76ee\u524d\uff0c\u544b\u55b9\u66ff\u5c3c\u9488\u5bf9\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u80c3\u764c\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\uff08\u88685\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u88685\uff1a\u544b\u55b9\u66ff\u5c3c\u5728\u7814\u9002\u5e94\u75c7<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;margin-top: 5px;margin-bottom: 5px;\"><img align=\"\" class=\"\"              style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1538271386.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"display: inline-block;vertical-align: top;padding: 5px;box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-width: 0px;box-sizing: border-box;\">\n<section style=\"margin-top: -10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;transform: translate3d(-10px, 0px, 0px);-webkit-transform: translate3d(-10px, 0px, 0px);-moz-transform: translate3d(-10px, 0px, 0px);-ms-transform: translate3d(-10px, 0px, 0px);-o-transform: translate3d(-10px, 0px, 0px);\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;border-width: 0px;box-sizing: border-box;\">\n<section style=\"margin-top: 20px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;transform: translate3d(5px, 0px, 0px);-webkit-transform: translate3d(5px, 0px, 0px);-moz-transform: translate3d(5px, 0px, 0px);-ms-transform: translate3d(5px, 0px, 0px);-o-transform: translate3d(5px, 0px, 0px);\">\n<section style=\"display: inline-block;vertical-align: top;border-style: dashed;border-width: 1px;border-radius: 0px;border-color: rgb(108, 171, 174);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"margin: -5px 0% 5px;box-sizing: border-box;transform: translate3d(-5px, 0px, 0px);-webkit-transform: translate3d(-5px, 0px, 0px);-moz-transform: translate3d(-5px, 0px, 0px);-ms-transform: translate3d(-5px, 0px, 0px);-o-transform: translate3d(-5px, 0px, 0px);\">\n<section style=\"display: inline-block;vertical-align: top;border-style: dashed;border-width: 1px;border-radius: 0px;border-color: rgb(108, 171, 174);padding:5px 10px 5px 10px;letter-spacing: 0px;background-color: rgb(254, 255, 255);box-sizing: border-box;\">\n<section style=\"margin-top: 5px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"color: rgb(108, 171, 174);font-size: 18px;line-height: 1.1;letter-spacing: 2px;box-sizing: border-box;\">\n<p style=\"margin-bottom: 10px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u76841\u7c7b\u65b0\u836f\u53ca\u5176\u76f8\u5173\u9776\u70b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u6211\u56fd\u5236\u836f\u4f01\u4e1a\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u7ba1\u7ebf\u54c1\u79cd\u4e30\u5bcc\uff0c\u9488\u5bf9EGFR\u3001ALK\u3001PD-1\u7b49\u70ed\u95e8\u9776\u70b9\u7684\u836f\u7269\u7814\u53d1\u5747\u6709\u5e03\u5c40\u3002\u76ee\u524d\uff0c\u5df2\u5411CDE\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u7684\u5316\u5b66\u836f1\u7c7b\u5019\u9009\u65b0\u836f\u67095\u4e2a\uff08\u88686\uff09\uff0c\u5305\u62ec\u827e\u68ee\u751f\u7269\u7684\u9a6c\u6765\u9178\u827e\u7ef4\u66ff\u5c3c\u3001\u8c6a\u68ee\u533b\u836f\u7684\u7532\u78fa\u9178\u6c1f\u9a6c\u66ff\u5c3c\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u7684\u8d5e\u5e03\u66ff\u5c3c\u7b49\u3002<\/span><br  \/><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u88686\uff1a\u5728\u4e2d\u56fd\u63d0\u4ea4NDA\u7684\u5728\u78141\u7c7b\u5316\u836f<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;\"><img align=\"\" class=\"\"              style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1538271386.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u827e\u68ee\u751f\u7269\u7684\u9a6c\u6765\u9178\u827e\u7ef4\u66ff\u5c3c\u662f\u56fd\u4ea7\u7b2c\u4e09\u4ee3EGFR\u6291\u5236\u5242\uff08\u9776\u5411EGFRT790M\u7a81\u53d8\uff09\u4e2d\u7814\u53d1\u8fdb\u5ea6\u6700\u5feb\u7684\u5019\u9009\u836f\u7269\u30022018\u5e746\u6708\uff0c\u8be5\u836f\u62df\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e0a\u5e02\u7533\u8bf7\u83b7CDE\u627f\u529e\u53d7\u7406\uff0c\u5e76\u4e8e8\u6708\u88ab\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff0c\u6709\u671b\u6210\u4e3a\u9996\u4e2a\u56fd\u5185\u81ea\u4e3b\u7814\u53d1\u5e76\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3EGFR\u6291\u5236\u5242\u3002\u76ee\u524d\u5728\u56fd\u5185\u83b7\u6279\u7684\u540c\u7c7b\u578b\u4ea7\u54c1\u53ea\u6709\u963f\u65af\u5229\u5eb7\u7684\u5965\u5e0c\u66ff\u5c3c\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u5728\u7814\u7684\u7b2c\u4e09\u4ee3EGFR\u6291\u5236\u5242\u8fd8\u5305\u62ec\u7532\u78fa\u9178\u827e\u6c1f\u66ff\u5c3c\u3001\u8fc8\u534e\u66ff\u5c3c\u3001BPI-15086\u3001YZJ-0318\u4ee5\u53caHS-10296\u7b49\uff08\u88687\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u88687\uff1a\u56fd\u5185\u5728\u7814\u7684\u4e3b\u8981\u7b2c\u4e09\u4ee3EGFR\u6291\u5236\u5242<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><img align=\"\" class=\"\"          style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1538271386.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 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52);\">\u7532\u78fa\u9178\u6c1f\u9a6c\u66ff\u5c3c\u662fBcr-abl\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5bf9\u6fc0\u9176\u7684\u6291\u5236\u4f5c\u7528\u5f3a\u4e8e\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u3002\u7532\u78fa\u9178\u6c1f\u9a6c\u66ff\u5c3c\u5bf9Bcr-abl\u7684\u4e0b\u6e38\u4fe1\u53f7\u5982ERK\u548cPDGFR\u4e5f\u6709\u6291\u5236\u4f5c\u7528\uff1b\u4f46\u5bf9\u5176\u5b83\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u5982EGFR\u3001VEGFR2\/KDR\u5219\u6ca1\u6709\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528\u3002\u8be5\u836f\u7531\u6c5f\u82cf\u8c6a\u68ee\u7814\u53d1\uff0c2013\u5e743\u6708\uff0c\u7532\u78fa\u9178\u6c1f\u9a6c\u66ff\u5c3c\u9996\u6b21\u5728\u4e2d\u56fd\u63d0\u4ea4\u751f\u4ea7\u7533\u8bf7\uff08\u672a\u83b7\u751f\u4ea7\u6279\u4ef6\uff0c\u540e\u7ee7\u7eed\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u53c8\u4e8e2014\u5e74\u63d0\u4ea4\u8865\u5145\u7533\u8bf7\uff0c\u4f46\u4ecd\u672a\u83b7\u6279\u4e0a\u5e02\uff09\u30022018\u5e747\u6708\uff0c\u7532\u78fa\u9178\u6c1f\u9a6c\u66ff\u5c3c\u518d\u6b21\u5728\u4e2d\u56fd\u63d0\u4ea4\u751f\u4ea7\u7533\u8bf7\uff0c\u4e14\u4e8e2018\u5e749\u6708\u83b7\u4e2d\u56fdNMPA\u7684\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff08Ph+ 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15px;\">\u8d5e\u5e03\u66ff\u5c3c\u662f\u7531\u767e\u6d4e\u795e\u5dde\u5f00\u53d1\u7684\u4e00\u6b3e\u5f3a\u6548\u4e14\u5177\u6709\u9ad8\u9009\u62e9\u6027\u7684\u5c0f\u5206\u5b50BTK\uff08Bruton\u916a\u6c28\u9178\u6fc0\u9176\uff09\u6291\u5236\u5242\uff0c\u4f5c\u4e3a\u5355\u4e00\u5236\u5242\u548c\u7ec4\u5408\u7597\u6cd5\u836f\u7269\u88ab\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u5404\u79cd\u6dcb\u5df4\u7624\uff0c\u8be5\u836f\u76ee\u524d\u5728\u591a\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u30022015\u5e746\u6708\uff0c\u8d5e\u5e03\u66ff\u5c3c\u83b7\u5f97FDA\u6279\u51c6\u5728\u7f8e\u56fd\u8fdb\u884c\u4e34\u5e8a\u7814\u7a76\uff0c\u4e4b\u540e\u57282016\u5e746\u6708\uff0c\u8be5\u836f\u9646\u7eed\u83b7\u5f97FDA\u6388\u4e88\u76843\u9879\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c\u5206\u522b\u7528\u4e8e\u6cbb\u7597\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u3001\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u548c\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u30022018\u5e747\u6708\uff0c\u8be5\u836f\u83b7\u5f97FDA\u7684\u5feb\u901f\u901a\u9053\u8d44\u683c\u7528\u4e8e\u6cbb\u7597\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005\u3002\u540c\u5e748\u6708\uff0c\u8d5e\u5e03\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u65b0\u836f\u7533\u8bf7\u83b7NMPA\u53d7\u7406\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 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style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u88688\uff1a\u56fd\u5185\u5728\u7814\u7684\u6297\u80bf\u7624\u9886\u57dfBTK\u6291\u5236\u5242<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><img align=\"\" class=\"\"             style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/9-1538271386.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u76ee\u524d\u6211\u56fd\u6297\u80bf\u76241\u7c7b\u751f\u7269\u836f\u7684\u7814\u53d1\u4e3b\u8981\u96c6\u4e2d\u5728\u514d\u75ab\u6cbb\u7597\u9886\u57df\uff0c\u5c3d\u7ba1\u4fe1\u8fbe\u3001\u541b\u5b9e\u3001\u767e\u6d4e\u795e\u5dde\u4ee5\u53ca\u6c5f\u82cf\u6052\u745e\u7684PD-1\u5355\u6297\u836f\u90fd\u63d0\u4ea4\u4e86\u4e0a\u5e02\u7533\u8bf7\uff08\u88689\uff09\uff0c\u4f46\u662f\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u7684Opdivo\u548c\u9ed8\u6c99\u4e1c\u7684Keytruda\u5df2\u7ecf\u76f8\u7ee7\u83b7\u5f97NMPA\u7684\u6279\u51c6\uff0c\u56fd\u5185PD-1\u836f\u7269\u7814\u53d1\u7ade\u4e89\u5f02\u5e38\u6fc0\u70c8\u3002\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u662f\u4e3a\u6570\u4e0d\u591a\u7684\u6211\u56fd\u7814\u53d1\u6c34\u5e73\u4e0e\u56fd\u9645\u7814\u53d1\u6c34\u5e73\u76f8\u5dee\u4e0d\u7b97\u592a\u5927\u7684\u9886\u57df\uff0cPD-(L)1\u4ee5\u53caCAR-T\u7597\u6cd5\u6211\u56fd\u81ea\u4e3b\u7814\u53d1\u5e76\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u4ea7\u54c1\u6570\u91cf\u4f17\u591a\uff0c\u800c\u9488\u5bf9\u5176\u5b83\u514d\u75ab\u6cbb\u7597\u9776\u70b9\uff08\u5982CD47\u3001LAG-3\u3001TIM-3\u7b49\uff09\u4e5f\u5df2\u7ecf\u6709\u6240\u5e03\u5c40\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u88689\uff1a\u5728\u4e2d\u56fd\u63d0\u4ea4BLA\u76841\u7c7b\u751f\u7269\u836f<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><img align=\"\" class=\"\"              style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/4-1538271387.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u9664\u4e86\u5df2\u7ecf\u7533\u8bf7\u4e0a\u5e02\u76844\u4e2aPD-1\u6297\u4f53\uff0c\u6211\u56fd\u5728\u7814\u7684PD-1\u6297\u4f53\u4e3b\u8981\u5904\u4e8e\u4e34\u5e8a\u2161\u671f\u548c\u2160\u671f\u7814\u7a76\u9636\u6bb5\u3002\u767e\u5965\u6cf0\u3001\u8a89\u8861\u836f\u4e1a\u4ee5\u53ca\u5609\u548c\u751f\u7269\u7684PD-1\u6297\u4f53\u90fd\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u2161\u671f\u7814\u7a76\u3002\u5eb7\u65b9\u751f\u7269\u6709\u4e09\u4e2aPD-1\u6297\u4f53\u5904\u5728\u2160\u671f\u4e34\u5e8a\uff0c\u5176\u4e2dAK-104\u662f\u4e00\u6b3e\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u53ef\u4ee5\u540c\u65f6\u9776\u5411CTLA-4\u548cPD-1\uff0cCTLA-4\u548cPD-1\u662f\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4T\u7ec6\u80de\u4e0a\u5171\u8868\u8fbe\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u86cb\u767d\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"color: rgb(62, 52, 52);font-size: 15px;\">\u56fd\u5185PD-L1\u6297\u4f53\u836f\u7269\u7814\u53d1\u8fdb\u7a0b\u6700\u5feb\u7684\u662f\u5eb7\u5b81\u6770\u745e\u4e0e\u601d\u8def\u8fea\u5171\u540c\u7814\u53d1\u7684KN-035\uff0c\u8be5\u836f\u9488\u5bf9\u80c6\u9053\u764c\u7684\u7814\u7a76\u5df2\u7ecf\u5904\u4e8e\u4e34\u5e8a\u2162\u671f\uff0c\u5eb7\u5b81\u6770\u745e\u7684\u53e6\u4e00\u6b3ePD-L1\u6297\u4f53KN-046\u4e5f\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u2160\u671f\u3002\u79d1\u4f26\u3001\u57fa\u77f3\u836f\u4e1a\u548c\u767e\u6d4e\u795e\u5dde\u5728PD-L1\u9886\u57df\u4e5f\u6709\u6240\u5e03\u5c40\uff0c\u5404\u81ea\u7684\u4ea7\u54c1\u90fd\u5728\u8fdb\u884c\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u590d\u5b8f\u6c49\u9716\u5728PD-1\u548cPD-L1\u9886\u57df\u5404\u6709\u4e00\u4e2a\u4ea7\u54c1\u5728\u8fdb\u884c\u4e34\u5e8a\u2160\u671f\u8bd5\u9a8c\uff08\u886810\uff09\u3002\u6211\u56fd\u81ea\u4e3b\u7814\u53d1\u7684PD-(L)1\u6297\u4f53\u9488\u5bf9\u7684\u9002\u5e94\u75c7\u4e3b\u8981\u4e3a\u56fd\u5185\u53d1\u75c5\u7387\u8f83\u9ad8\u7684\u764c\u79cd\uff0c\u591a\u4e3a\u809d\u764c\u3001\u80ba\u764c\u7b49\u5b9e\u4f53\u7624\uff0c\u9488\u5bf9\u9ed1\u8272\u7d20\u7624\u7684\u7814\u53d1\u5e76\u4e0d\u591a\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u886810\uff1a\u6211\u56fd\u4e34\u5e8a\u5728\u7814PD-(L)1\u6297\u4f53\u836f<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"612\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" width=\"660\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/10-1538271387.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"display: inline-block;vertical-align: top;padding: 5px;box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-width: 0px;box-sizing: border-box;\">\n<section style=\"margin-top: -10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;transform: translate3d(-10px, 0px, 0px);-webkit-transform: translate3d(-10px, 0px, 0px);-moz-transform: translate3d(-10px, 0px, 0px);-ms-transform: translate3d(-10px, 0px, 0px);-o-transform: translate3d(-10px, 0px, 0px);\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;border-width: 0px;box-sizing: border-box;\">\n<section style=\"margin-top: 20px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;transform: translate3d(5px, 0px, 0px);-webkit-transform: translate3d(5px, 0px, 0px);-moz-transform: translate3d(5px, 0px, 0px);-ms-transform: translate3d(5px, 0px, 0px);-o-transform: translate3d(5px, 0px, 0px);\">\n<section style=\"display: inline-block;vertical-align: top;border-style: dashed;border-width: 1px;border-radius: 0px;border-color: rgb(108, 171, 174);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"margin: -5px 0% 5px;box-sizing: border-box;transform: translate3d(-5px, 0px, 0px);-webkit-transform: translate3d(-5px, 0px, 0px);-moz-transform: translate3d(-5px, 0px, 0px);-ms-transform: translate3d(-5px, 0px, 0px);-o-transform: translate3d(-5px, 0px, 0px);\">\n<section style=\"display: inline-block;vertical-align: top;border-style: dashed;border-width: 1px;border-radius: 0px;border-color: rgb(108, 171, 174);padding:5px 10px 5px 10px;letter-spacing: 0px;background-color: rgb(254, 255, 255);box-sizing: border-box;\">\n<section style=\"margin-top: 5px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"color: rgb(108, 171, 174);font-size: 18px;line-height: 1.1;letter-spacing: 2px;box-sizing: border-box;\">\n<p style=\"margin-bottom: 10px;box-sizing: border-box;\"><strong style=\"box-sizing: 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52);\">\u76ee\u524d\uff0c\u5728\u6211\u56fd\u5904\u4e8e\u4e34\u5e8a\u2162\u671f\u7814\u7a76\u9636\u6bb5\u76841\u7c7b\u5019\u9009\u65b0\u836f\u670924\u4e2a\uff0c\u5176\u4e2d\u5316\u5b66\u836f\u4e3a18\u4e2a\uff0c\u751f\u7269\u836f\u4e3a6\u4e2a\uff08\u886811\uff09\u3002\u4ee5VGRFR\u4e3a\u4f5c\u7528\u9776\u70b9\u7684\u836f\u7269\u6570\u91cf\u8f83\u591a\uff0c\u5305\u62ec\u82f9\u679c\u9178\u6cd5\u7c73\u66ff\u5c3c\u3001\u7532\u82ef\u78fa\u9178\u591a\u7eb3\u975e\u5c3c\u3001Vorolanib\u3001\u7d22\u51e1\u66ff\u5c3c\u3001\u4e19\u6c28\u9178\u5e03\u7acb\u5c3c\u5e03\u4ee5\u53ca\u751f\u7269\u836f\u91cd\u7ec4\u4eba\u5185\u76ae\u6291\u7d20\u3002\u7d22\u51e1\u66ff\u5c3c\u662f\u7531\u548c\u8bb0\u9ec4\u57d4\u7814\u53d1\uff0c\u9488\u5bf9\u80f0\u817a\u795e\u7ecf\u5185\u5206\u6ccc\u80bf\u7624\u5904\u4e8e\u4e34\u5e8a\u2162\u671f\u7814\u7a76\uff0c\u9488\u5bf9\u7532\u72b6\u817a\u9ad3\u6837\u764c\u548c\u80c6\u9053\u764c\u7684\u7814\u7a76\u5904\u4e8e\u4e34\u5e8a\u2161\u671f\uff0c\u548c\u8bb0\u9ec4\u57d4\u4fdd\u7559\u7d22\u51e1\u66ff\u5c3c\u5728\u5168\u7403\u7684\u6240\u6709\u6743\u5229\u3002<\/span><br  \/><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;line-height: normal;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u886811\uff1a\u5728\u6211\u56fd\u5904\u4e8e\u4e34\u5e8a\u2162\u671f\u7814\u7a76\u76841\u7c7b\u5019\u9009\u65b0\u836f<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"870\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" width=\"660\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/8-1538271388.jpg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u8fd1\u5e74\u6765\uff0c\u548c\u8bb0\u9ec4\u57d4\u7684\u6297\u80bf\u7624\u521b\u65b0\u836f\u7814\u53d1\u52bf\u5934\u8fc5\u731b\uff0c\u9664\u7d22\u51e1\u66ff\u5c3c\u4ee5\u5916\u8fd8\u6709\u4e24\u4e2a\u836f\u7269\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u2162\u671f\u7814\u7a76\uff0c\u5206\u522b\u4e3a\u7425\u73c0\u9178\u4f9d\u5421\u66ff\u5c3c\u548c\u6c83\u5229\u66ff\u5c3c\u3002\u6c83\u5229\u66ff\u5c3c\u662f\u4e00\u6b3e\u9ad8\u9009\u62e9\u6027\u7684c-Met\u53e3\u670d\u6291\u5236\u5242\uff0c\u5c24\u5176\u662f\u5bf9\u643a\u5e26c-Met\u57fa\u56e0\u6269\u589e\u6216c-Met 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52);\">\u76ee\u524d\uff0c\u5168\u7403\u6682\u65f6\u8fd8\u6ca1\u6709\u9009\u62e9\u6027\u7684c-Met\u6291\u5236\u5242\u6210\u529f\u4e0a\u5e02\uff0c\u800c\u6c83\u5229\u66ff\u5c3c\u6709\u671b\u6210\u4e3a\u201cfirst-in-class\u201d\u54c1\u79cd\uff0c\u6210\u4e3a\u5168\u7403\u7b2c\u4e00\u4e2a\u9ad8\u9009\u62e9\u6027c-Met\u9776\u5411\u836f\u3002\u56fd\u5185\u5728\u7814\u7684c-Met\u6291\u5236\u5242\u9664\u4e86\u6c83\u5229\u66ff\u5c3c\uff0c\u90fd\u5904\u4e8e\u4e34\u5e8a\u2160\/\u2161\u671f\u7814\u7a76\u9636\u6bb5\uff0c\u5176\u4e2d\u5305\u62ec\u4e00\u4e9b\u591a\u9776\u70b9\u6291\u5236\u5242\uff08\u886812\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u886812\uff1a\u6211\u56fdc-Met\u6291\u5236\u5242\u4e34\u5e8a\u5728\u7814\u836f\u7269<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><img align=\"\" class=\"\"             style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1538271389.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u6069\u66ff\u8bfa\u7279\u662f\u4e00\u6b3e\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176\uff08HDAC\uff09\u6291\u5236\u5242\uff0c\u76ee\u524d\u5904\u4e8e\u4e34\u5e8aIII\u671f\uff0c\u7528\u4e8e\u6cbb\u7597\u6297\u96cc\u6fc0\u7d20\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u8fdb\u5c55\u7684\u7edd\u7ecf\u540e\u3001\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u3002\u8be5\u836f\u6700\u65e9\u7531\u4e09\u4e95\u5236\u836f\u7814\u53d1\uff0c\u62dc\u8033\u5148\u7075\u8446\u96c5\u5236\u836f\u516c\u53f8\u901a\u8fc7\u6536\u8d2d\u4e09\u4e95\u5236\u836f\u83b7\u5f97\u8be5\u5316\u5408\u7269\uff1b2007\u5e74\uff0cSyndax\u4ece\u62dc\u8033\u5148\u7075\u8446\u96c5\u5236\u836f\u516c\u53f8\u83b7\u5f97\u8be5\u5316\u5408\u7269\u7684\u5168\u7403\u6392\u4ed6\u6027\u6743\u5229\uff1b2013\u5e74\uff0c\u4ebf\u817e\u836f\u4e1a\u83b7\u5f97\u8be5\u836f\u5728\u4e2d\u56fd\u53ca\u90e8\u5206\u4e9a\u6d32\u56fd\u5bb6\u7684\u5f00\u53d1\u6743\u5229\u3002\u76ee\u524d\u56fd\u5185\u9664\u4e862014\u5e74\u83b7\u6279\u7684\u897f\u8fbe\u672c\u80fa\uff0c\u5904\u4e8e\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u7684HDAC\u6291\u5236\u5242\u67096\u4e2a\uff08\u886813\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u886813\uff1a\u56fd\u5185\u4e34\u5e8a\u5728\u7814\u7684HDAC\u6291\u5236\u5242<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><img align=\"\" class=\"\"             style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/7-1538271389.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">PARP\u6291\u5236\u5242Pamiparib\uff08BGB-290\uff09\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u6cbb\u7597\u5375\u5de2\u764c\u548c\u80c3\u764c\u7684\u4e34\u5e8a\u2162\u671f\u8bd5\u9a8c\u3002\u767e\u6d4e\u795e\u5dde\u4e5f\u662f\u4ee5\u6297\u80bf\u7624\u836f\u7269\u4e3a\u4e3b\u8981\u9886\u57df\u7684\u521b\u65b0\u836f\u7814\u53d1\u4f01\u4e1a\uff0c\u5176BTK\u6291\u5236\u5242\u548cPD-1\u6297\u4f53\u90fd\u5df2\u7ecf\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u3002Pamiparib\u4e5f\u662f\u767e\u6d4e\u795e\u5dde\u7814\u53d1\u7ba1\u7ebf\u4e2d\u7684\u91cd\u70b9\u4ea7\u54c1\uff0c\u636e\u5b98\u7f51\u6d88\u606f\uff0cPamiparib\u5728\u9009\u62e9\u6027\u3001DNA\u6355\u83b7\u6d3b\u6027\u3001\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u548c\u8840\u8111\u5c4f\u969c\u901a\u900f\u6027\u65b9\u9762\uff0c\u5177\u6709\u533a\u522b\u4e8e\u5305\u62ec\u5965\u62c9\u5e15\u5c3c\u5728\u5185\u7684\u5176\u4ed6PARP\u6291\u5236\u5242\u7684\u6f5c\u529b\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u53e6\u5916\uff0cPamiparib\u663e\u793a\u51fa\u7684\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u975e\u5e38\u6709\u5229\u4e8e\u8be5\u836f\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6216\u5316\u7597\u836f\u7269\u7684\u8054\u5408\u4f7f\u7528\u3002\u76ee\u524d\u56fd\u5185\u4e34\u5e8a\u5728\u7814\u7684PARP\u6291\u5236\u5242\u9664\u4e86Pamiparib\uff0c\u90fd\u5904\u5728\u4e34\u5e8a\u2160\u671f\u7814\u7a76\u9636\u6bb5\uff0c\u4e2d\u79d1\u9662\u4e0a\u6d77\u836f\u7269\u6240\u67092\u4e2a\u4ea7\u54c1\u5728\u7814\uff08\u5e0c\u660e\u54cc\u745e\u3001\u76d0\u9178\u7f8e\u544b\u54cc\u745e\uff09\uff0c\u4eba\u798f\u3001\u9752\u5cf0\u3001\u8c6a\u68ee\u3001\u5929\u58eb\u529b\u548c\u745b\u6d3e\u836f\u4e1a\u5404\u67091\u4e2a\u4ea7\u54c1\u5728\u7814\uff08\u886814\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u886814\uff1a\u6211\u56fd\u4e34\u5e8a\u5728\u7814PARP\u6291\u5236\u5242<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><img align=\"\" class=\"\"             style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1538271389.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u8d1d\u8fbe\u4e0eXcovery\u516c\u53f8\u5408\u4f5c\u5f00\u53d1\u7684Ensartinib\uff08\u7231\u6c99\u66ff\u5c3c\uff09\u5728\u56fd\u5185ALK\u6291\u5236\u5242\u7814\u53d1\u9886\u57df\u5904\u4e8e\u7814\u53d1\u8fdb\u5ea6\u8f83\u4e3a\u9886\u5148\u7684\u4f4d\u7f6e\uff0c\u8be5\u836f\u6700\u521d\u7531Xcovery\u7814\u53d1\uff0c2014\u5e74\u6388\u6743\u7ed9\u8d1d\u8fbe\u836f\u4e1a\u3002\u7231\u6c99\u66ff\u5c3c\u5728\u56fd\u5185\u5916\u5747\u6709\u7533\u62a5\uff0c\u9488\u5bf9\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u7814\u7a76\u56fd\u5185\u5916\u90fd\u5728\u5f00\u5c55\u2162\u671f\u4e34\u5e8a\u3002\u76ee\u524d\uff0c\u5168\u7403\u4e0a\u5e02\u76844\u4e2aALK\u6291\u5236\u5242\u67093\u4e2a\u90fd\u5df2\u7ecf\u5728\u4e2d\u56fd\u4e0a\u5e02\uff08\u514b\u5511\u66ff\u5c3c\u3001\u8272\u745e\u66ff\u5c3c\u3001\u963f\u6765\u66ff\u5c3c\uff09\uff0c\u53e6\u5916\uff0c\u6b63\u5728\u56fd\u5185\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u7684ALK\u6291\u5236\u5242\u6570\u91cf\u5e76\u4e0d\u5c11\uff08\u886815\uff09\uff0c\u7231\u6c99\u66ff\u5c3c\u9762\u4e34\u7684\u7ade\u4e89\u5c06\u4f1a\u76f8\u5f53\u6fc0\u70c8\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u886815\uff1a\u6211\u56fd\u4e34\u5e8a\u5728\u7814\u7684ALK\u6291\u5236\u5242<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><img align=\"\" class=\"\"             style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1538271390.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">BAT8001\u662f\u767e\u5965\u6cf0\u5f00\u53d1\u7684\u9996\u4e2aADC\u836f\u7269\uff0c\u4e3a\u91cd\u7ec4\u4eba\u6e90\u5316\u6297ErbB2\/ Neu\/HER2\u5355\u514b\u9686\u6297\u4f53\u901a\u8fc7\u8fde\u63a5\u5b50\u4e0e\u7f8e\u767b\u7d20\u836f\u7269\u884d\u751f\u7269\u8fdb\u884c\u5076\u8054\u800c\u6210\u3002\u5176\u8fde\u63a5\u5b50\u5bf9\u9178\u4e0d\u654f\u611f\u3001\u5bf9\u80bd\u9176\u7ec4\u7ec7\u86cb\u767d\u9176\u4e0d\u654f\u611f\u5e76\u4e14\u4e0d\u542b\u4e8c\u786b\u952e\uff0c\u53ef\u7ef4\u6301\u5076\u8054\u7269\u5728\u8fdb\u5165\u7ec6\u80de\u524d\u7684\u7a33\u5b9a\u6027\u3002\u8be5\u836f\u662f\u76f4\u63a5\u8df3\u8fc7\u2161\u671f\u4e34\u5e8a\uff0c\u6210\u4e3a\u56fd\u5185\u9996\u4e2a\u8fdb\u5165\u2162\u671f\u4e34\u5e8a\u7684\u56fd\u4ea7ADC\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597HER2+\u5b9e\u4f53\u7624\u3002\u76ee\u524d\u5168\u7403\u8303\u56f4\u5185\u83b7\u6279\u4e0a\u5e02\u7684ADC\u836f\u7269\u67094\u4e2a\uff0c\u5df2\u4e0a\u5e02\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\u4e2d\uff0c\u5e02\u573a\u8868\u73b0\u6700\u597d\u7684\u4fbf\u662f\u7f57\u6c0f\u9776\u5411Her2\u7684\u4e73\u817a\u764c\u836f\u7269Kadcyla\uff0c2017\u5e74\u5168\u7403\u9500\u552e\u989d\u8fbe\u52309.3\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u6211\u56fd\u672c\u571f\u4f01\u4e1a\u5728\u7814\u7684ADC\u836f\u7269\u4e3b\u8981\u6709\u8363\u660c\u751f\u7269\u7684RC48-ADC\u3001\u6d59\u6c5f\u533b\u836f\u7684ARX788\u3001\u6052\u745e\u533b\u836f\u7684SHR-A1201\u3001SHR-A1403\u4ee5\u53ca\u7f8e\u96c5\u73c2\u7684MRG003\u7b49\uff08\u886816\uff09\u3002\u8363\u660c\u751f\u7269\u7684RC48-ADC\u662f\u56fd\u5185\u9996\u4e2a\u9012\u4ea4\u9776\u5411HER2\u6297\u4f53\u5076\u8054\u836f\u7269\u4e34\u5e8a\u7533\u8bf7\u5e76\u83b7\u5f97\u4e34\u5e8a\u6279\u4ef6\u7684\u5728\u7814\u836f\u7269\uff0c\u76ee\u524d\u5728\u8fdb\u884c\u4e34\u5e8a\u2161\u671f\u7814\u7a76\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;margin-bottom: 5px;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u886816\uff1a\u6211\u56fd\u4e34\u5e8a\u5728\u7814\u7684\u4e3b\u8981ADC\u836f\u7269<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><img align=\"\" class=\"\"             style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/1-1538271390-1.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"display: inline-block;vertical-align: top;padding: 5px;box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-width: 0px;box-sizing: border-box;\">\n<section style=\"margin-top: -10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;transform: translate3d(-10px, 0px, 0px);-webkit-transform: translate3d(-10px, 0px, 0px);-moz-transform: translate3d(-10px, 0px, 0px);-ms-transform: translate3d(-10px, 0px, 0px);-o-transform: translate3d(-10px, 0px, 0px);\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;border-width: 0px;box-sizing: border-box;\">\n<section style=\"margin-top: 20px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;transform: translate3d(5px, 0px, 0px);-webkit-transform: translate3d(5px, 0px, 0px);-moz-transform: translate3d(5px, 0px, 0px);-ms-transform: translate3d(5px, 0px, 0px);-o-transform: translate3d(5px, 0px, 0px);\">\n<section style=\"display: inline-block;vertical-align: top;border-style: dashed;border-width: 1px;border-radius: 0px;border-color: rgb(108, 171, 174);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"margin: -5px 0% 5px;box-sizing: border-box;transform: translate3d(-5px, 0px, 0px);-webkit-transform: translate3d(-5px, 0px, 0px);-moz-transform: translate3d(-5px, 0px, 0px);-ms-transform: translate3d(-5px, 0px, 0px);-o-transform: translate3d(-5px, 0px, 0px);\">\n<section style=\"display: inline-block;vertical-align: top;border-style: dashed;border-width: 1px;border-radius: 0px;border-color: rgb(108, 171, 174);padding:5px 10px 5px 10px;letter-spacing: 0px;background-color: rgb(254, 255, 255);box-sizing: border-box;\">\n<section style=\"margin-top: 5px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"color: rgb(108, 171, 174);font-size: 18px;line-height: 1.1;letter-spacing: 2px;box-sizing: border-box;\">\n<p style=\"margin-bottom: 10px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5176\u5b83\u70ed\u95e8\u6280\u672f\u53ca\u9776\u70b9\u7684\u7814\u53d1\u60c5\u51b5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>CAR-T\u7ec6\u80de\u7597\u6cd5<\/strong><\/span><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u6211\u56fd\u7533\u8bf7\u4e34\u5e8a\u7684CAR-T\u7597\u6cd5\u5927\u591a\u6570\u4ee5CD19\u4e3a\u9776\u70b9\uff0c\u5176\u6b21\u662f\u4ee5BCMA\u4e3a\u9776\u70b9\uff0c\u53ea\u6709\u79d1\u6d4e\u751f\u7269\u7684\u4e00\u9879CAR-T\u7597\u6cd5\u662f\u4ee5GPC3\u4e3a\u9776\u70b9\uff0c\u5176\u5728\u7814\u9002\u5e94\u75c7\u4e3a\u80ba\u764c\u548c\u809d\u7ec6\u80de\u764c\u3002\u5357\u4eac\u4f20\u5947\u3001\u5b89\u79d1\u751f\u7269\u3001\u666e\u745e\u91d1\u751f\u7269\u3001\u5317\u4eac\u827a\u5999\u533b\u7597\u79d1\u6280\u4ee5\u53ca\u6052\u6da6\u8fbe\u751f\u90fd\u6709\u5404\u81ea\u7684\u4ea7\u54c1\u63a8\u8fdb\u5230\u4e34\u5e8a\u2161\u671f\uff0c\u79d1\u6d4e\u751f\u7269\u67093\u9879CAR-T\u7597\u6cd5\u8fdb\u5165\u4e34\u5e8a\u2160\u671f\u7814\u7a76\uff0c\u660e\u805a\u751f\u7269\u7684CAR-T\u7597\u6cd5\u4e5f\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u2160\u671f\u3002\u53e6\u5916\uff0c\u5f53\u524d\u6b63\u5728\u7533\u8bf7\u4e34\u5e8a\u4f46\u8fd8\u5728\u5ba1\u8bc4\u4e2d\u7684\u516c\u53f8\u6709\u4f18\u5361\u8fea\u3001\u7cbe\u51c6\u751f\u7269\u3001\u534e\u9053\u751f\u7269\u3001\u6052\u6da6\u8fbe\u751f\u4ee5\u53ca\u6df1\u5733\u56e0\u8bfa\u514d\u75ab\uff08\u886817\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);margin-bottom: 5px;text-indent: 0em;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u886817\uff1a\u6211\u56fd\u4e34\u5e8a\u5728\u7814CAR-T\u7597\u6cd5<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"510\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" width=\"660\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/6-1538271391.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>PI3K\/mTOR\u6291\u5236\u5242<\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u5728\u591a\u79cd\u764c\u75c7\u4e2d\uff0cPI3K-AKT-mTOR\u901a\u8def\u662f\u8fc7\u5ea6\u6d3b\u5316\u7684\uff0c\u56e0\u6b64\u51cf\u5c11\u51cb\u4ea1\u4fc3\u8fdb\u589e\u6b96\u3002\u7814\u7a76\u8868\u660e\uff0c\u9776\u5411PI3K-AKT-mTOR\u901a\u8def\u7684\u6291\u5236\u5242\u5bf9\u6cbb\u7597\u80bf\u7624\u6709\u79ef\u6781\u4f5c\u7528\u3002\u76ee\u524d\u5728\u80bf\u7624\u6cbb\u7597\u9886\u57df\uff0cFDA\u6279\u51c6\u4e0a\u5e02\u7684mTOR\u6291\u5236\u5242\u6709\u8f89\u745e\u516c\u53f8\u7684\u66ff\u897f\u7f57\u83ab\u53f8\u548c\u8bfa\u534e\u7684\u4f9d\u7ef4\u83ab\u53f8\uff1bFDA\u6279\u51c6\u4e0a\u5e02\u7684PI3K\u6291\u5236\u5242\u4e3a\u5409\u5229\u5fb7\u7684\u827e\u5fb7\u62c9\u5c3c\u548c\u62dc\u8033\u7684Copanlisib Hydrochloride\u3002\u56fd\u5185PI3K-AKT-mTOR\u901a\u8def\u6291\u5236\u5242\u90fd\u5904\u4e8e\u65e9\u671f\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff08\u886818\uff09\uff0c\u6839\u636e\u4f5c\u7528\u673a\u5236\u4e0d\u540c\uff0c\u4e3b\u8981\u5206\u4e3a3\u7c7b\uff1a\u5e7f\u8c31PI3K\u6291\u5236\u5242\uff0c\u4f5c\u7528\u4e8eI\u7c7bPI3K\u7684\u56db\u79cd\u4e9a\u578b\uff1b\u4e9a\u578b\u7279\u5f02\u578bPI3K\u6291\u5236\u5242\u4ee5\u53ca\u4f5c\u7528\u4e8ePI3K\u548cmTOR\u7684\u53cc\u9776\u70b9\u6291\u5236\u5242\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);margin-bottom: 5px;text-indent: 0em;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u886818\uff1a\u56fd\u5185\u5728\u7814PI3K\/mTOR\u6291\u5236\u5242<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"654\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" width=\"660\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/09\/5-1538271392.jpeg\" alt=\"\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 128, 255);\"><strong>CDK4\/6\u6291\u5236\u5242<\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u7ec6\u80de\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u9176\uff08cyclin dependent kinases\uff0cCDKs\uff09\u5728\u7ec6\u80de\u5468\u671f\u7684\u542f\u52a8\u548c\u5404\u4e2a\u65f6\u671f\u7684\u8f6c\u6362\u8c03\u8282\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u76ee\u524dFDA\u6279\u51c6\u4e0a\u5e02\u7684CDK4\/6\u6291\u5236\u5242\u67093\u4e2a\uff1a\u8f89\u745e\u7684Ibrance\uff08\u5e15\u5e03\u6614\u5229\u5e03\uff09\u3001\u8bfa\u534e\u7684Kisqali\uff08Ribociclib\uff09\u4ee5\u53ca\u793c\u6765\u7684Verzenio\uff08Abemaciclib\uff09\u3002CDK4\/6\u6291\u5236\u5242\u663e\u8457\u5ef6\u957f\u4e86ER+\/HER2-\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3002CDK4\/6\u6291\u5236\u5242\u76ee\u524d\u56fd\u5185\u7814\u53d1\u8fdb\u5c55\u6700\u5feb\u662f\u7684\u6052\u745e\u7684SHR6390\uff0c\u76ee\u524d\u5728\u8fdb\u884c\u4e34\u5e8a\u2161\u671f\u7814\u7a76\uff08\u886819\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u886819\uff1a\u56fd\u5185\u5728\u7814CDK4\/6\u6291\u5236\u5242<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"display: inline-block;vertical-align: top;padding: 5px;box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-width: 0px;box-sizing: border-box;\">\n<section style=\"margin-top: -10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;transform: translate3d(-10px, 0px, 0px);-webkit-transform: translate3d(-10px, 0px, 0px);-moz-transform: translate3d(-10px, 0px, 0px);-ms-transform: translate3d(-10px, 0px, 0px);-o-transform: translate3d(-10px, 0px, 0px);\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;border-width: 0px;box-sizing: border-box;\">\n<section style=\"margin-top: 20px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;transform: translate3d(5px, 0px, 0px);-webkit-transform: translate3d(5px, 0px, 0px);-moz-transform: translate3d(5px, 0px, 0px);-ms-transform: translate3d(5px, 0px, 0px);-o-transform: translate3d(5px, 0px, 0px);\">\n<section style=\"display: inline-block;vertical-align: top;border-style: dashed;border-width: 1px;border-radius: 0px;border-color: rgb(108, 171, 174);background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section style=\"margin: -5px 0% 5px;box-sizing: border-box;transform: translate3d(-5px, 0px, 0px);-webkit-transform: translate3d(-5px, 0px, 0px);-moz-transform: translate3d(-5px, 0px, 0px);-ms-transform: translate3d(-5px, 0px, 0px);-o-transform: translate3d(-5px, 0px, 0px);\">\n<section style=\"display: inline-block;vertical-align: top;border-style: dashed;border-width: 1px;border-radius: 0px;border-color: rgb(108, 171, 174);padding:5px 10px 5px 10px;letter-spacing: 0px;background-color: rgb(254, 255, 255);box-sizing: border-box;\">\n<section style=\"margin-top: 5px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"color: rgb(108, 171, 174);font-size: 18px;line-height: 1.1;letter-spacing: 2px;box-sizing: border-box;\">\n<p style=\"margin-bottom: 10px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5c0f\u7ed3<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u6211\u56fd\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u6240\u53d6\u5f97\u7684\u6210\u7ee9\uff0c\u79bb\u4e0d\u5f00\u76d1\u7ba1\u3001\u5236\u836f\u4f01\u4e1a\u548c\u79d1\u7814\u9662\u6240\u7684\u5171\u540c\u52aa\u529b\u3002\u83b7\u6279\u7684\u8fdb\u53e3\u836f\u7269\u548c\u56fd\u4ea7\u836f\u7269\u90fd\u4e3a\u6211\u56fd\u80bf\u7624\u60a3\u8005\u5e26\u6765\u65b0\u7684\u66f4\u6709\u76ca\u7684\u6cbb\u7597\u9009\u62e9\u3002\u8fd1\u5e74\u6765\uff0c\u6211\u56fd\u6297\u80bf\u7624\u5236\u836f\u4f01\u4e1a\u4e0e\u56fd\u5916\u836f\u4f01\u5408\u4f5c\u7814\u53d1\u7684\u6848\u4f8b\u6bd4\u6bd4\u7686\u662f\uff0c\u6c5f\u82cf\u6052\u745e\u3001\u548c\u8bb0\u9ec4\u57d4\u3001\u767e\u6d4e\u795e\u5dde\u7b49\u521b\u65b0\u836f\u7814\u53d1\u4f01\u4e1a\u9010\u6e10\u8d70\u4e0a\u56fd\u9645\u821e\u53f0\uff0c\u5728\u56fd\u5185\u5916\u540c\u65f6\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u56fd\u9645\u5f71\u54cd\u529b\u9010\u6e10\u589e\u5f3a\u3002\u6c5f\u82cf\u6052\u745e\u65e0\u7591\u662f\u56fd\u5185\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u9886\u57df\u7684\u9f99\u5934\u4f01\u4e1a\uff0c\u5728\u51e0\u4e4e\u6240\u6709\u7684\u6297\u80bf\u7624\u70ed\u95e8\u9776\u70b9\u90fd\u6709\u6240\u5e03\u5c40\u3002\u6211\u56fd\u5728\u6297\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u9886\u57df\u4e0e\u56fd\u5916\u7814\u53d1\u6c34\u5e73\u5dee\u8ddd\u8f83\u5c0f\uff0cPD-(L)1\u6291\u5236\u5242\u4e0eCAR-T\u7ec6\u80de\u7597\u6cd5\u7814\u53d1\u7ba1\u7ebf\u6709\u5f88\u591a\u6709\u6f5c\u529b\u7684\u4ea7\u54c1\u3002\u5728BTK\u3001PARP\u3001ALK\u3001HDAC\u7b49\u70ed\u95e8\u9776\u70b9\u7814\u53d1\u9886\u57df\u4e5f\u6709\u4e00\u6279\u5904\u4e8e\u4e34\u5e8a\u7814\u53d1\u540e\u671f\u7684\u6f5c\u529b\u4ea7\u54c1\u3002\u671f\u5f85\u5728\u672a\u6765\u51e0\u5e74\uff0c\u8fd9\u4e9b\u4ea7\u54c1\u6709\u671b\u8d70\u5411\u5e02\u573a\uff0c\u4e3a\u6211\u56fd\u80bf\u7624\u60a3\u8005\u5e26\u6765\u798f\u97f3\u3002<\/span><br  \/><\/p>\n<p style=\"font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 5px;margin-bottom: 5px;line-height: 1.5em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\"><strong style=\"font-size: 15px;text-indent: 2em;\">\u53c2\u8003\u8d44\u6599<\/strong><br  \/><\/span><\/p>\n<p style=\"font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 5px;margin-bottom: 5px;line-height: 1.5em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">1\u3001\tClarivate Analytics Cortellis\u6570\u636e\u5e93\uff0c\u68c0\u7d22\u65e5\u671f\uff1a2018\u5e749\u670810\u65e5\uff1b<\/span><\/p>\n<p style=\"font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;margin-top: 5px;margin-bottom: 5px;line-height: 1.5em;\"><span 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