{"id":52921,"date":"2018-09-28T01:00:00","date_gmt":"2018-09-30T01:39:05","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e5%a6%8a%e5%a8%a0%e6%9c%9f%e5%a5%b3%e6%80%a7%e7%99%ab%e7%97%ab%e7%ae%a1%e7%90%86%e5%8f%8a-epi-%e7%94%a8%e8%8d%af%e6%8c%87%e5%8d%97%e8%af%a6%e8%a7%a3\/"},"modified":"2018-09-30T09:39:08","modified_gmt":"2018-09-30T01:39:08","slug":"%e5%a6%8a%e5%a8%a0%e6%9c%9f%e5%a5%b3%e6%80%a7%e7%99%ab%e7%97%ab%e7%ae%a1%e7%90%86%e5%8f%8a-epi-%e7%94%a8%e8%8d%af%e6%8c%87%e5%8d%97%e8%af%a6%e8%a7%a3","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/52921\/","title":{"rendered":"\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u7ba1\u7406\u53ca EPI \u7528\u836f\u6307\u5357\u8be6\u89e3"},"content":{"rendered":"
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\u672c\u6587\u4ece\u598a\u5a20\u671f\u766b\u75eb\u53d1\u4f5c\u9891\u7387\u5f71\u54cd\u56e0\u7d20\u3001\u598a\u5a20\u671f\u6297\u766b\u75eb\u836f\u7269\uff08AEDs\uff09\u836f\u4ee3\u52a8\u529b\u5b66\u53d8\u5316\u3001\u5b55\u524d\u53f6\u9178\u4f7f\u7528\u3001\u5b55\u4e2d AEDs \u4f7f\u7528\u3001\u5206\u5a29\u671f\u95f4\u4ea7\u79d1\u98ce\u9669\u3001\u65b0\u751f\u513f\u5065\u5eb7\u3001\u6bcd\u4e73\u5582\u517b\u7b49\u591a\u89d2\u5ea6\u5168\u9762\u5730\u63a2\u8ba8\u4e86\u598a\u5a20\u671f\u766b\u75eb\u5973\u6027\u7684\u89c4\u8303\u5316\u7ba1\u7406\u3002<\/p>\n


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\u25b7\u9996\u5148\u63d0\u5230\u591a\u79cd\u751f\u7406\u53d8\u5316\u53ca\u5fc3\u7406\u56e0\u7d20\u5747\u53ef\u589e\u52a0\u598a\u5a20\u671f\u766b\u75eb\u53d1\u4f5c\u9891\u7387<\/strong>\uff0c\u56e0\u6b64\uff0c\u63a8\u8350\u672a\u89e3\u9664\u766b\u75eb\u8bca\u65ad\u7684\u60a3\u8005\u5e94\u7ee7\u7eed\u4f7f\u7528 AEDs, \u4f46\u662f\u7279\u522b\u5f3a\u8c03\u907f\u514d\u4f7f\u7528\u5fb7\u5df4\u91d1\u3001\u82ef\u5df4\u6bd4\u59a5\u7b49\u81f4\u7578\u6027\u5f3a\u7684\u836f\u7269\u3002<\/p>\n


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\u25b7\u4fa7\u9762\u63d0\u793a\u4e86\u766b\u75eb\u53d1\u4f5c\uff0c\u7279\u522b\u662f\u5168\u9762\u5f3a\u76f4\u9635\u631b\u53d1\u4f5c\uff0c\u5bf9\u540e\u4ee3\u5f71\u54cd\u5927\u4e8e LEV\u3001LTG \u7b49\u81f4\u7578\u6027\u5c0f\u7684 AEDs \u5bf9\u540e\u4ee3\u7684\u5f71\u54cd\u3002\u672c\u6587\u5f3a\u8c03\u4e86\u5b55\u524d\u53f6\u9178\u4f7f\u7528\u7684\u5fc5\u8981\u6027\uff0c\u53ef\u964d\u4f4e\u540e\u4ee3\u795e\u7ecf\u7ba1\u7578\u5f62\u98ce\u9669\uff0c\u6587\u4e2d\u867d\u7136\u63d0\u5230\u53f6\u9178\u591a\u79cd\u7528\u6cd5\uff0c\u4f46\u662f\u5927\u591a\u6570\u6307\u5357\u63a8\u8350\u53f6\u9178\u4f7f\u7528\u5242\u91cf\u4e3a 5 mg\/\u5929\u3002<\/p>\n


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\u5c3d\u7ba1\u672c\u6587\u5f3a\u8c03\u5b55\u671f\u6b63\u89c4\u670d\u7528 AEDs \u5927\u591a\u6570\u766b\u75eb\u5973\u6027\u53ef\u751f\u80b2\u5065\u5eb7\u540e\u4ee3\uff0c\u4f46\u4ecd\u5b58\u5728\u589e\u52a0\u65b0\u751f\u513f\u5065\u5eb7\u7684\u98ce\u9669\uff0c\u4f8b\u5982\uff0c\u51fa\u751f\u4f53\u91cd\u4f4e\u3001\u5c0f\u4e8e\u80ce\u9f84\u513f (SGA)\u3001Apgar \u8bc4\u5206\u4f4e\u7b49\u3002<\/p>\n


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\u7531\u6b64\u53ef\u89c1\uff0c\u751f\u80b2\u671f WWE \u9700\u8981\u766b\u75eb\u4e13\u79d1\u3001\u5987\u4ea7\u79d1\u3001\u513f\u79d1\u3001\u65b0\u751f\u513f\u79d1\u7b49\u591a\u5b66\u79d1\u5171\u540c\u7ba1\u7406\u3002<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ea7\u524d\u66b4\u9732\u4e8e\u6297\u766b\u75eb\u836f\u7269 (AEDs) \u53ef\u80fd\u5bfc\u81f4\u80ce\u513f\u5148\u5929\u7578\u5f62 (MCM)\u3001\u5bab\u5185\u53d1\u80b2\u8fdf\u7f13\u3001\u8ba4\u77e5\u969c\u788d\u7b49\u95ee\u9898\uff0c\u5f15\u8d77\u8ba1\u5212\u598a\u5a20\u7684\u5973\u6027\u766b\u75eb\u60a3\u8005 (WWE) \u7684\u6781\u5927\u5173\u6ce8\u3002<\/span><\/p>\n


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\u5df2\u6709\u7814\u7a76\u4e3a\u8fd9\u4e9b\u95ee\u9898\u63d0\u4f9b\u4e86\u6709\u4ef7\u503c\u7684\u6570\u636e\u3002\u7f8e\u56fd Patel SI \u548c Pennell PB \u53d1\u8868\u4e86\u4e00\u7bc7\u7efc\u8ff0\uff0c\u56de\u987e\u4e86\u6700\u65b0\u7684\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u60a3\u8005\u5173\u6ce8\u95ee\u9898\uff0c\u5305\u62ec AED \u836f\u4ee3\u52a8\u529b\u5b66\u3001AEDs \u4e34\u5e8a\u7ba1\u7406\u3001MCM\u3001\u5206\u5a29\u8fc7\u7a0b\u4e2d\u7684\u4ea7\u79d1\u98ce\u9669\u3001\u795e\u7ecf\u53d1\u80b2\u7ed3\u5c40\u3001\u56f4\u4ea7\u671f\u5e76\u53d1\u75c7\u53ca\u6bcd\u4e73\u5582\u517b\u7b49\u95ee\u9898\u3002<\/span><\/p>\n


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\u54ea\u4e9b\u56e0\u7d20\u5f71\u54cd\u598a\u5a20\u671f\u766b\u75eb\u53d1\u4f5c\u9891\u7387\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u598a\u5a20\u4e0e\u591a\u79cd\u751f\u7406<\/strong><\/span>\u3001\u5185\u5206\u6ccc\u548c\u5fc3\u7406\u53d8\u5316\u76f8\u5173<\/span>\uff0c\u4efb\u4f55\u4e00\u79cd\u56e0\u7d20\u5747\u6709\u53ef\u80fd\u964d\u4f4e\u766b\u75eb\u53d1\u4f5c\u9608\u503c\u3002<\/strong>\u5e76\u4e14\uff0c\u598a\u5a20\u671f\u7684\u751f\u7406\u53d8\u5316\u5f71\u54cd AEDs \u836f\u4ee3\u52a8\u529b\u5b66\uff0c\u53ef\u80fd\u5bfc\u81f4\u60a3\u8005\u766b\u75eb\u7684\u6076\u5316\u3002<\/span>
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\u5df2\u6709\u7814\u7a76\u8bc1\u660e\uff0c\u598a\u5a20\u671f\u766b\u75eb\u53d1\u4f5c\u9891\u7387\u7684\u6700\u4f73\u9884\u6d4b\u6307\u6807\u662f\u598a\u5a20\u524d 1 \u5e74\u7684\u53d1\u4f5c\u9891\u7387\u3002\u800c\u766b\u75eb\u6076\u5316\u5219\u7531\u591a\u56e0\u7d20\u5bfc\u81f4\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u7528\u836f\u4f9d\u4ece\u6027\u5dee\u3001AEDs \u6d53\u5ea6\u964d\u4f4e\u53ca AEDs \u4ee3\u8c22\u6539\u53d8\u3001\u6fc0\u7d20\u6539\u53d8\u3001\u7761\u7720\u5265\u593a\u53ca\u5fc3\u7406\u538b\u529b\u3002<\/p>\n


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\u598a\u5a20\u671f AEDs \u836f\u4ee3\u52a8\u529b\u5b66\u6709\u4f55\u53d8\u5316\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u598a\u5a20\u671f AEDs \u8840\u6d46\u6d53\u5ea6\u4f1a\u56e0\u836f\u7269\u5438\u6536\u3001\u80be\u6e05\u9664\u7387\u589e\u52a0\u3001\u809d\u6e05\u9664\u7387\u6539\u53d8\u3001\u8840\u6d46\u5bb9\u91cf\u5206\u5e03\u589e\u52a0\u53ca\u5973\u6027\u6fc0\u7d20\u5bf9\u809d\u810f\u9176\u7684\u8bf1\u5bfc\u4f5c\u7528\u800c\u6ce2\u52a8\u3002<\/strong><\/p>\n


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\u7406\u60f3\u60c5\u51b5\u4e0b\uff0c\u5e94\u5728\u598a\u5a20\u524d\u6839\u636e\u766b\u75eb\u75c5\u53f2\u548c\u6cbb\u7597\u6d53\u5ea6\u4e2a\u4f53\u5316\u786e\u5b9a AEDs \u7684\u76ee\u6807\u8840\u6d46\u6d53\u5ea6\u3002\u4e3a\u907f\u514d\u766b\u75eb\u53d1\u4f5c\uff0c\u9700\u5728\u598a\u5a20\u671f\u4fdd\u6301 AEDs \u7684\u76ee\u6807\u6c34\u5e73\uff0cAEDs \u5242\u91cf\u5e94\u6839\u636e\u9700\u8981\u8fdb\u884c\u8c03\u6574\u3002<\/span><\/p>\n


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\u67d0\u4e9b ADEs\uff0c\u5982\u5de6\u4e59\u62c9\u897f\u5766 (LEV)<\/span> \u3001<\/span>\u62c9\u83ab\u4e09\u55ea (LTG)\u3001\u548c\u5965\u5361\u897f\u5e73 (OXC)\uff0cMCM \u53d1\u751f\u7387\u4f4e\uff0c\u6240\u4ee5\u662f\u8ba1\u5212\u598a\u5a20 WWE \u7684\u6cbb\u7597\u9009\u62e9\u3002\u8fd9\u7c7b AEDs \u5728\u598a\u5a20\u671f\u56e0\u6e05\u9664\u589e\u52a0\u5f15\u8d77\u836f\u7269\u8840\u6d46\u6d53\u5ea6\u7684\u6539\u53d8\uff0c\u9700\u8981\u5bc6\u5207\u76d1\u6d4b\u3002<\/span><\/p>\n


<\/p>\n

\u5c3d\u7ba1\u598a\u5a20\u671f\u66f4\u503e\u5411\u4e8e\u4f7f\u7528\u65b0\u578b\u548c\u7b2c\u4e09\u4ee3 AEDs\uff0c\u4f46\u4e16\u754c\u8303\u56f4\u5185\u4ecd\u6709\u4e00\u90e8\u5206\u60a3\u8005\u53ea\u80fd\u4f7f\u7528\u4f20\u7edf AEDs\u3002\u5c0f\u90e8\u5206\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u4f20\u7edf AEDs\uff0c\u5982\u5361\u9a6c\u897f\u5e73 (CBZ)\u3001\u82ef\u5df4\u6bd4\u59a5 (PB)\u3001\u82ef\u59a5\u82f1\u94a0 (PHT) \u548c\u4e19\u620a\u9178 (VPA)\uff0c\u6574\u4e2a\u598a\u5a20\u671f\u8840\u6d46\u6d53\u5ea6\u5747\u4f1a\u964d\u4f4e\uff0c\u5c24\u5176\u662f\u5728\u598a\u5a20\u665a\u671f\u3002<\/p>\n


<\/p>\n

\u598a\u5a20\u671f\u8fdb\u884c\u6cbb\u7597\u836f\u7269\u76d1\u6d4b\u4ee5\u7ef4\u6301\u598a\u5a20\u524d AED \u7684\u76ee\u6807\u6c34\u5e73\uff0c\u6709\u52a9\u4e8e\u9632\u6b62\u598a\u5a20\u671f\u766b\u75eb\u7684\u6076\u5316\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982\u4f55\u6709\u6548\u907f\u514d AEDs \u5f15\u8d77\u7684\u81f4\u7578\u6027\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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MCM \u901a\u5e38\u88ab\u5b9a\u4e49\u4e3a\u300c\u598a\u5a20\u65e9\u671f\u5668\u5b98\u5f62\u6210\u9636\u6bb5\u53d1\u751f\u7684\u5916\u79d1\u3001\u5185\u79d1\u3001\u529f\u80fd\u6216\u7f8e\u5bb9\u7684\u91cd\u8981\u7684\u7ed3\u6784\u5f02\u5e38\u300d<\/strong>\u3002<\/span><\/p>\n


<\/p>\n

\u82e5\u5e72\u5168\u7403\u598a\u5a20\u767b\u8bb0\u8c03\u67e5\u4e86\u5bab\u5185\u66b4\u9732\u4e8e AEDs \u5bfc\u81f4\u7684\u80ce\u513f\u7578\u5f62\u53d1\u751f\u7387\uff0c\u5176\u4e2d\u8f83\u4e3a\u5927\u578b\u7684\u524d\u77bb\u6027 AEDs \u598a\u5a20\u767b\u8bb0\u5305\u62ec\u5317\u7f8e\u6297\u766b\u75eb\u836f\u7269\u598a\u5a20\u767b\u8bb0 (NAAPR)\u3001\u82f1\u56fd\u766b\u75eb\u4e0e\u598a\u5a20\u767b\u8bb0\u53ca\u6b27\u6d32\u6297\u766b\u75eb\u836f\u7269\u4e0e\u598a\u5a20\u767b\u8bb0 (EURAP)\u3002\u8fd9\u4e9b\u598a\u5a20\u767b\u8bb0\u62a5\u9053\u7684\u4e0e AEDs \u76f8\u5173 MCM \u7ed3\u679c\u89c1\u8868 1\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u598a\u5a20\u767b\u8bb0\u6570\u636e\u663e\u793a\uff0cVPA \u5355\u836f\u53ca\u8054\u5408\u6cbb\u7597\u80ce\u513f MCM \u53d1\u751f\u7387\u6700\u9ad8\uff0c\u5176\u6b21\u662f PB \u548c\u6258\u5421\u916f (TPM)\u3002VPA \u5242\u91cf\u8d8a\u9ad8\uff0cMCM \u53d1\u751f\u7387\u66f4\u9ad8\u3002<\/span><\/p>\n


<\/p>\n

\u4e00\u822c\u6765\u8bf4\uff0c\u76f8\u6bd4\u5355\u836f\u6cbb\u7597\uff0c\u5bab\u5185\u66b4\u9732\u4e8e\u591a\u836f\u8054\u5408 MCM \u53d1\u751f\u7387\u66f4\u9ad8\u3002\u82f1\u56fd\u548c\u7231\u5c14\u5170\u598a\u5a20\u767b\u8bb0\u8fd1\u671f\u62a5\u9053\uff0c\u5e38\u7528\u4e8e\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u60a3\u8005\u7684 LEV \u5148\u5929\u7578\u5f62\u53d1\u751f\u98ce\u9669\u4f4e\u3002<\/span>
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\u8868 1  \u598a\u5a20\u671f\u66b4\u9732\u4e8e\u4e0d\u540c AEDs \u5355\u836f\u6cbb\u7597\u5f15\u8d77\u7684\u80ce\u513f\u5148\u5929\u7578\u5f62\u53d1\u751f\u7387<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u7ba1\u7406\u53ca<\/section>\n<\/section>\n<\/section>\n
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CI\uff1a\u7f6e\u4fe1\u533a\u95f4<\/span>
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\u6b64\u7c7b\u7814\u7a76\u603b\u7ed3\u5982\u4e0b\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9996\u5148\uff0c\u80b2\u9f84\u671f\u5973\u6027\u5e94\u5c3d\u53ef\u80fd\u907f\u514d\u4f7f\u7528 VPA\u3002\u5982\u67d0\u4e00\u60a3\u8005\u6240\u6709\u66ff\u4ee3\u65b9\u6848\u5931\u8d25\uff0c\u4ec5 VPA \u80fd\u63a7\u5236\u766b\u75eb\u53d1\u4f5c\uff0c\u90a3\u4e48\u5c3d\u53ef\u80fd\u4f7f\u7528\u80fd\u5408\u7406\u63a7\u5236\u766b\u75eb\u7684\u6700\u4f4e\u5242\u91cf\uff0c\u5e94\u8bbe\u6cd5\u7ef4\u6301 VPA \u65e5\u5242\u91cf\uff1c700 mg\/\u5929\u3002<\/p>\n


<\/p>\n

\u5176\u6b21\uff0c\u598a\u5a20\u65e9\u671f AEDs \u7684\u6570\u91cf\u53ca\u5242\u91cf\u5e94\u5c3d\u91cf\u51cf\u5c11\uff0c\u4ee5\u964d\u4f4e\u80ce\u513f MCM \u98ce\u9669\uff0c\u540c\u65f6\u5e94\u6839\u636e\u4e2a\u4f53\u766b\u75eb\u7279\u5f81\u548c\u76ee\u6807\u6d53\u5ea6\u7ef4\u6301\u766b\u75eb\u63a7\u5236\uff1b\u518d\u6b21\uff0cLEV \u548c LTG \u5355\u836f\u53ca\u8054\u5408\u7528\u836f\u81f4\u7578\u7387\u8f83\u4f4e\uff0c\u56e0\u6b64\u662f\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u60a3\u8005\u7684\u7406\u60f3\u7528\u836f\u9009\u62e9\uff1b\u6700\u540e\uff0c\u76d1\u6d4b\u6cbb\u7597\u836f\u7269\u53ef\u9884\u9632\u598a\u5a20\u671f\u766b\u75eb\u6076\u5316\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n<\/section>\n
\n
\n
\n
\n

\u5982\u4f55\u964d\u4f4e WWE \u5206\u5a29\u671f\u95f4\u7684\u4ea7\u79d1\u98ce\u9669\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5973\u6027\u766b\u75eb\u60a3\u8005\u4ea7\u79d1\u5e76\u53d1\u75c7\u98ce\u9669\u53ef\u80fd\u589e\u52a0\uff0c\u5305\u62ec\u6b7b\u4ea1 (\u589e\u52a0 10 \u500d\u4ee5\u4e0a)\u3001\u5256\u5bab\u4ea7\u3001\u5148\u5146\u5b50\u75eb\u3001\u5148\u5146\u5b50\u75eb\u7684\u766b\u75eb\u53d1\u4f5c\u3001\u5f15\u4ea7\u3001\u4e25\u91cd\u4ea7\u540e\u51fa\u8840\u3001\u65e9\u4ea7\u3001\u80ce\u819c\u65e9\u7834\u3001\u7ed2\u6bdb\u819c\u7f8a\u819c\u708e\u98ce\u9669\u53ca\u4f4f\u9662\u65f6\u95f4\u5ef6\u957f\u3002<\/span>
<\/p>\n


<\/p>\n

\u5973\u6027\u766b\u75eb\u60a3\u8005\uff0c\u5c24\u5176\u662f\u63a5\u53d7 AEDs \u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5e94\u63a5\u53d7\u5206\u5a29\u671f\u95f4\u53ef\u80fd\u53d1\u751f\u4ea7\u79d1\u5e76\u53d1\u75c7\u7684\u6559\u80b2\u3002\u56e0\u5176\u4ea7\u79d1\u5e76\u53d1\u75c7\u589e\u52a0\uff0c\u6545\u6b64\u7c7b\u60a3\u8005\u5728\u5206\u5a29\u8fc7\u7a0b\u4e2d\u9700\u4ed4\u7ec6\u76d1\u6d4b\u3002\u6b64\u5916\uff0c\u9488\u5bf9\u5206\u5a29\u8fc7\u7a0b\u4e2d\u5177\u6709\u6f5c\u5728\u4ea7\u79d1\u5e76\u53d1\u75c7\u98ce\u9669\u7684\u5973\u6027\u766b\u75eb\u60a3\u8005\uff0c\u5987\u4ea7\u79d1\u533b\u751f\u5e94\u7ed9\u4e88\u9f13\u52b1\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n
<\/section>\n<\/section>\n
\n
\n
\n
\n

\u5a74\u513f\u56f4\u4ea7\u671f\u7ed3\u5c40\u5982\u4f55\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u63a5\u53d7 AEDs \u6cbb\u7597\u7684\u5973\u6027\u766b\u75eb\u60a3\u8005\u5206\u5a29\u7684\u65b0\u751f\u513f\u51fa\u73b0\u56f4\u4ea7\u671f\u5e76\u53d1\u75c7\u98ce\u9669\u66f4\u9ad8\uff0c\u5305\u62ec\u51fa\u751f\u4f53\u91cd\u4f4e\u3001\u5c0f\u4e8e\u80ce\u9f84\u513f (SGA)\u3001Apgar \u8bc4\u5206*\u4f4e\u3001\u5c0f\u5934\u7578\u5f62\u3001\u547c\u5438\u95ee\u9898\u53ca\u9001\u5165\u65b0\u751f\u513f\u76d1\u62a4\u5ba4\u3002<\/span>
<\/p>\n


<\/p>\n

\u8fd1\u5e74\u6765\u7814\u7a76\u6570\u636e\u8868\u660e\uff0cVPA \u4e0e SGA\u30011 \u5206\u949f Apgar \u8bc4\u5206\u53ca\u5c0f\u5934\u7578\u5f62\u76f8\u5173\u3002\u5e94\u544a\u77e5\u60a3\u8005\u4f7f\u7528 AEDs \u7684\u6f5c\u5728\u56f4\u4ea7\u671f\u5e76\u53d1\u75c7\uff0c\u5e76\u4e14\u5e94\u907f\u514d\u4f7f\u7528 VPA\u3002\u82e5\u5fc5\u987b\u4f7f\u7528 VPA \u6cbb\u7597\uff0c\u9700\u544a\u77e5\u60a3\u8005\u4e0e VPA \u76f8\u5173\u7684\u6f5c\u5728\u56f4\u4ea7\u671f\u5e76\u53d1\u75c7\u3002<\/p>\n

*Apgar \u8bc4\u5206\uff1a\u5373\u963f\u6c0f\u8bc4\u5206\u3001\u65b0\u751f\u513f\u8bc4\u5206\uff0c\u5305\u62ec\uff1a\u808c\u5f20\u529b\u3001\u8109\u640f\u3001\u76b1\u7709\u52a8\u4f5c\u5373\u5bf9\u523a\u6fc0\u7684\u53cd\u5e94\u3001\u5916\u8c8c\u3001\u547c\u5438\u3002\u6ee1 10 \u5206\u8005\u4e3a\u6b63\u5e38\u65b0\u751f\u513f\uff0c\u8bc4\u5206 7 \u5206\u4ee5\u4e0b\u7684\u65b0\u751f\u513f\u8003\u8651\u60a3\u6709\u8f7b\u5ea6\u7a92\u606f\uff0c\u8bc4\u5206\u5728 4 \u5206\u4ee5\u4e0b\u8003\u8651\u60a3\u6709\u91cd\u5ea6\u7a92\u606f\u3002\u5927\u90e8\u5206\u65b0\u751f\u513f\u7684\u8bc4\u5206\u591a\u5728 7 – 10 \u5206\u4e4b\u95f4<\/span>
<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n<\/section>\n
\n
\n
\n
\n

AEDs \u66b4\u9732\u7684\u5a74\u513f\u795e\u7ecf\u8ba4\u77e5\u529f\u80fd\u53d1\u5c55\u5982\u4f55\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u80ce\u513f\u66b4\u9732\u4e8e AEDs \u4e0e\u8f83\u9ad8\u7684\u795e\u7ecf\u53d1\u80b2\u7f3a\u9677\u98ce\u9669\u76f8\u5173\u3002\u8fd1\u671f\u7814\u7a76\u5df2\u5f00\u59cb\u5173\u6ce8\u5b50\u5bab\u5185\u66b4\u9732\u4e8e AEDs \u5bfc\u81f4\u7684\u8ba4\u77e5\u529f\u80fd\u969c\u788d (\u6216\u79f0\u4e3a\u300c\u8ba4\u77e5\u81f4\u7578\u6027\u300d)\u3002 <\/span><\/p>\n


<\/p>\n

\u6297\u766b\u75eb\u836f\u7269\u795e\u7ecf\u53d1\u80b2\u5f71\u54cd\u7814\u7a76 (NEAD \u7814\u7a76) \u8bc1\u5b9e\uff0c\u66b4\u9732\u4e8e VPA \u5355\u836f\u6cbb\u7597\u7684\u513f\u7ae5 6 \u5c81\u65f6\u667a\u5546 (IQ) \u4f4e\u4e8e\u66b4\u9732\u4e8e CBZ\u3001LTG \u6216 PHT\u3002<\/span><\/p>\n


<\/p>\n

\u53e6\u4e00\u9879\u524d\u77bb\u6027\u7814\u7a76\u8868\u660e\uff0c\u76f8\u6bd4\u5bf9\u7167\u7ec4\uff0cWWE \u540e\u4ee3\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u53d1\u751f\u7387\u66f4\u9ad8\u3002\u66b4\u9732\u4e8e VPA \u5355\u836f\u6216\u8054\u5408\u6cbb\u7597\u7684\u513f\u7ae5\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u98ce\u9669\u589e\u52a0\uff0c\u4ee5\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d (ASD) \u6700\u4e3a\u5e38\u89c1\u3002<\/span>
<\/p>\n


<\/p>\n

\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u53ef\u7528\u4e8e\u6559\u80b2\u8ba1\u5212\u598a\u5a20\u7684 WWE\uff0c\u6216\u7528\u4e8e\u8bc6\u522b\u66b4\u9732\u4e8e AEDs \u513f\u7ae5\u53ef\u80fd\u53d1\u751f\u7684\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n<\/section>\n
\n
\n
\n
\n

\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u60a3\u8005\u9700\u8981\u8865\u5145\u53f6\u9178\u5417\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e00\u822c\u4eba\u7fa4\u4e2d\uff0c\u53f6\u9178\u7f3a\u4e4f\u4e0e\u795e\u7ecf\u7ba1\u7f3a\u9677 (NTD) \u76f8\u5173\uff0c\u9002\u5f53\u8865\u5145\u53f6\u9178 (0.36-4.0 mg) \u53ef\u4f7f NTD \u98ce\u9669\u964d\u4f4e 60-86%\uff0c\u4f46\u662f\u5bf9\u4e8e WWE \u4eba\u7fa4\uff0c\u5c24\u5176\u662f\u63a5\u53d7 AEDs \u6cbb\u7597\u7684 WWE\uff0c\u8fd9\u79cd\u5173\u8054\u5e76\u672a\u5f97\u5230\u786e\u8ba4\u3002<\/span>
<\/p>\n


<\/p>\n

\u5927\u591a\u6570\u533b\u751f\u5efa\u8bae WWE \u670d\u7528\u53f6\u9178\u6765\u9884\u9632 NTD\uff0c\u4f46\u662f\u5242\u91cf\u5c1a\u672a\u660e\u786e\uff0c\u7f8e\u56fd\u795e\u7ecf\u75c5\u5b66\u4f1a (ANN) \u5efa\u8bae\u80b2\u9f84\u671f\u5973\u6027\u598a\u5a20\u524d\u53ca\u598a\u5a20\u671f\u95f4\u53f6\u9178\u81f3\u5c11\u6bcf\u5929 0.4 mg\uff0c\u800c\u591a\u6570\u4e13\u5bb6\u5efa\u8bae\u5242\u91cf\u4e3a 1-5 mg \u6bcf\u5929\u3002\u672a\u6765\u9700\u8981\u66f4\u591a\u7684\u7814\u7a76\u8fdb\u4e00\u6b65\u786e\u5b9a\u63a5\u53d7 AEDs \u6cbb\u7597\u7684 WWE \u670d\u7528\u53f6\u9178\u9884\u9632 NTD \u548c MCM \u7684\u5242\u91cf\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n<\/section>\n
\n
\n
\n
\n

\u63a5\u53d7 AEDs \u6cbb\u7597\u53ef\u4ee5\u6bcd\u4e73\u5582\u517b\u5417\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6bcd\u4e73\u5582\u517b\u5bf9\u6bcd\u5a74\u5065\u5eb7\u6709\u8bb8\u591a\u76ca\u5904\uff0c\u4f46\u662f\uff0c\u591a\u6570 WWE \u62c5\u5fc3\u6bcd\u4e73\u5582\u517b\u5ef6\u957f\u5a74\u513f AEDs \u7684\u66b4\u9732\u65f6\u95f4\u3002\u60a3\u8005\u9700\u4e0e\u8d1f\u8d23\u5206\u5a29\u7684\u533b\u7597\u56e2\u961f\u53ca\u513f\u79d1\u533b\u751f\u8ba8\u8bba\u6bcd\u4e73\u5582\u517b\u83b7\u76ca\u4e0e\u65b0\u751f\u513f\u836f\u7269\u66b4\u9732\u98ce\u9669\u95f4\u7684\u5229\u5f0a\u3002<\/strong><\/span>
<\/p>\n


<\/p>\n

\u6bcd\u4e73\u5582\u517b\u65f6 AEDs \u5bf9\u5a74\u513f\u7684\u5f71\u54cd\u53d6\u51b3\u4e8e\u591a\u79cd\u56e0\u7d20\uff0c\u5305\u62ec\u6bcd\u4f53\u8840\u6d46\u836f\u7269\u6d53\u5ea6\u3001\u836f\u7269\u7684\u4e73\u6c41\/\u8840\u6d46\u6bd4\u3001\u5a74\u513f\u6444\u5165\u7684\u5976\u91cf\u4ee5\u53ca\u836f\u7269\u5728\u5a74\u513f\u4f53\u5185\u7684\u5438\u6536\u3001\u4ee3\u8c22\u548c\u6e05\u9664\u3002\u5373\u4f7f\u5728\u6bcd\u4e73\u4e2d\u51fa\u73b0 AEDs\uff0c\u65b0\u751f\u513f\u66b4\u9732\u4e8e\u836f\u7269\u7684\u7a0b\u5ea6\u4ecd\u53ef\u80fd\u5c0f\u4e8e\u598a\u5a20\u671f\u95f4\u7684\u66b4\u9732\u7a0b\u5ea6\u3002<\/p>\n


<\/p>\n

\u4e00\u822c\u6765\u8bf4\uff0c\u86cb\u767d\u7ed3\u5408\u529b\u5c0f\u3001\u8102\u6eb6\u6027\u5f3a\u7684 AEDs \u66f4\u5bb9\u6613\u5728\u6bcd\u4e73\u4e2d\u5206\u5e03\u3002\u4e3a\u4e86\u5c3d\u91cf\u51cf\u5c11\u5a74\u513f\u66b4\u9732\u4e8e AED\uff0c\u6bcd\u4f53 AEDs \u9700\u8981\u7ef4\u6301\u8f83\u4f4e\u7684\u6709\u6548\u5242\u91cf\uff0c\u5982\u53d1\u73b0\u6f5c\u5728\u4e0d\u826f\u53cd\u5e94\u8ff9\u8c61 (\u55dc\u7761\uff0c\u5582\u517b\u4e0d\u826f)\uff0c\u9700\u76d1\u6d4b\u5a74\u513f\u4f53\u5185\u8840\u6d46\u836f\u7269\u6d53\u5ea6\u3002<\/p>\n


<\/p>\n

\u8fd1\u671f\u7814\u7a76\u6570\u636e\u8868\u660e\uff0c\u6bcd\u4e73\u5582\u517b\u83b7\u76ca\u5927\u4e8e\u98ce\u9669\uff0c\u5e94\u9f13\u52b1\u63a5\u53d7 AEDs \u6cbb\u7597\u7684\u5973\u6027\u766b\u75eb\u60a3\u8005\u9009\u62e9\u6bcd\u4e73\u5582\u517b\u3002<\/span><\/strong><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u598a\u5a20\u671f WWE \u7684\u6cbb\u7597\u76ee\u6807\u662f\u5bab\u5185\u80ce\u513f\u5c3d\u91cf\u5c11\u66b4\u9732\u4e8e AEDs \u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u6700\u4f73\u7684\u766b\u75eb\u63a7\u5236\uff0c\u4ee5\u51cf\u5c11\u4e0d\u826f\u7ed3\u5c40\u548c\u795e\u7ecf\u53d1\u80b2\u81f4\u7578\u7684\u98ce\u9669\u3002\u598a\u5a20\u671f\u751f\u7406\u53d8\u5316\u4f1a\u5f71\u54cd AEDs \u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff0c\u53ef\u80fd\u5bfc\u81f4\u766b\u75eb\u6076\u5316\uff0c\u598a\u5a20\u671f\u548c\u4ea7\u540e\u8fdb\u884c\u6cbb\u7597\u836f\u7269\u76d1\u6d4b\uff0c\u8c03\u6574 AEDs \u5242\u91cf\u53ef\u5e2e\u52a9\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\u3002<\/span><\/p>\n


<\/p>\n

\u63a5\u53d7 AEDs \u6cbb\u7597\u7684 WWE \u9700\u8fdb\u884c\u5173\u4e8e\u6f5c\u5728 MCM\u3001\u795e\u7ecf\u53d1\u80b2\u7ed3\u5c40\u3001\u4ea7\u79d1\u98ce\u9669\u3001\u56f4\u4ea7\u671f\u5e76\u53d1\u75c7\u548c\u54fa\u4e73\u7684\u6559\u80b2\u3002\u598a\u5a20\u671f\u5973\u6027\u60a3\u8005\u7684\u7ba1\u7406\u975e\u5e38\u91cd\u8981\uff0c\u5fc5\u987b\u5f3a\u8c03\u7684\u662f\uff0c\u5c3d\u7ba1\u62a4\u7406\u8fc7\u7a0b\u590d\u6742\uff0c\u7edd\u5927\u591a\u6570\u7684 WWE \u90fd\u53ef\u4ee5\u62e5\u6709\u5065\u5eb7\u7684\u598a\u5a20\u3002<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u598a\u5a20\u5973\u6027\u766b\u75eb\u60a3\u8005\u53d1\u4f5c\u9891\u7e41\uff0c\u4f7f\u598a\u5a20\u76f8\u5173\u5e76\u53d1\u75c7\u98ce\u9669\u589e\u52a0\u3002\u5904\u65b9\u6297\u766b\u75eb\u836f\u7269 (AEDs) \u53ef\u964d\u4f4e\u766b\u75eb\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u4f46\u670d\u7528 AEDs \u7684\u5987\u5973\u6d41\u4ea7\u548c\u80ce\u513f\u7578\u5f62\u7684\u98ce\u9669\u53ef\u80fd\u66f4\u5927\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u901a\u8fc7\u80ce\u76d8\u4ece\u800c\u5f71\u54cd\u80ce\u513f\uff0c\u636e\u62a5\u9053\u540e\u4ee3\u60a3\u6709\u4e3b\u8981\u5148\u5929\u6027\u7578\u5f62 (CM) \u7684\u53ef\u80fd\u6027\u4e3a 4-8%\u3002<\/p>\n


<\/p>\n

\u8fd1\u5e74\u6765\u6210\u7acb\u4e86\u51e0\u4e2a\u5927\u89c4\u6a21\u598a\u5a20\u767b\u8bb0\u673a\u6784\uff0c\u7528\u4ee5\u8bc4\u4f30\u4f20\u7edf\u548c\u65b0\u578b AEDs \u7684\u5b89\u5168\u6027\u3002\u7136\u800c\uff0c\u6211\u4eec\u5bf9\u5bab\u5185 AED \u66b4\u9732\u5b89\u5168\u6027\u7684\u300c\u6bd4\u8f83\u300d\u77e5\u4e4b\u751a\u5c11\uff0c\u800c\u4e14\u4ee5\u524d\u591a\u79cd AED \u6bd4\u8f83\u7684\u7814\u7a76\u5f80\u5f80\u6837\u672c\u91cf\u5f88\u5c0f\u4e14\u4e0d\u5177\u6743\u5a01\u6027\u3002\u56e0\u6b64\uff0c\u672c\u6587\u901a\u8fc7\u7cfb\u7edf\u8bc4\u4ef7\u548c\u7f51\u7edc\u835f\u8403\u5206\u6790\u6bd4\u8f83\u4e86\u5bab\u5185 AEDs \u66b4\u9732\u7684\u5b89\u5168\u6027\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8bc4\u4f30\u65b9\u6cd5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7eb3\u5165\u6807\u51c6\uff1a\u56e0\u4efb\u4f55\u9002\u5e94\u75c7\u670d\u7528 AEDs \u7684\u598a\u5a20\u5973\u6027\u5747\u4e3a\u7814\u7a76\u5bf9\u8c61\u3002\u56e0\u6b64\uff0c\u51e1\u62a5\u9053\u4efb\u610f\u5242\u91cf\u7684\u4f20\u7edf AEDs(\u5361\u9a6c\u897f\u5e73\uff0c\u6c2f\u5df4\u5360\uff0c\u6c2f\u785d\u897f\u6cee\uff0c\u4e59\u7425\u80fa\uff0c\u82ef\u5df4\u6bd4\u59a5\uff0c\u82ef\u59a5\u82f1\uff0c\u6251\u75eb\u916e\uff0c\u4e19\u620a\u9178) \u548c\u65b0\u578b AEDs(\u52a0\u5df4\u55b7\u4e01\uff0c\u62c9\u83ab\u4e09\u55ea\uff0c\u5de6\u4e59\u62c9\u897f\u5766\uff0c\u5965\u5361\u897f\u5e73\uff0c\u6258\u5421\u916f\uff0c\u6c28\u5df1\u70ef\u9178) \u6cbb\u7597\u7684\u7814\u7a76\u5747\u88ab\u7eb3\u5165\u3002\u5bf9\u7167\u7ec4\u591a\u4e3a\u5b89\u6170\u5242\u6216\u672a\u63a5\u53d7 AED \u6cbb\u7597\u7684\u766b\u75eb\u5973\u6027\u60a3\u8005\uff0c\u4ee5\u53ca\u4e0e\u5176\u4ed6 AEDs \u6cbb\u7597\u6bd4\u8f83\u3002<\/span>
<\/p>\n


<\/p>\n

\u8bc4\u4f30\u6307\u6807\uff1a\u4e3b\u8981\u7ed3\u679c\u662f\u603b\u4f53\u548c\u7279\u5b9a\u7c7b\u578b\u4e3b\u8981\u5148\u5929\u6027\u7578\u5f62\u7684\u53d1\u751f\u7387\uff0c\u662f\u6307\u5728\u51fa\u751f\u65f6\u5373\u5177\u6709\u624b\u672f\u3001\u836f\u7269\u3001\u529f\u80fd\u6216\u7f8e\u5bb9\u5fc5\u8981\u7684\u7578\u5f62\u3002\u7279\u5b9a\u7c7b\u578b\u7684\u5148\u5929\u6027\u7578\u5f62\uff0c\u6700\u5e38\u62a5\u9053\u7684\u5305\u62ec 6 \u7c7b\uff0c\u5206\u522b\u4e3a\uff1a\u5fc3\u810f\u7578\u5f62\uff0c\u5c3f\u9053\u4e0b\u88c2\uff0c\u5507\/\u816d\u88c2\uff0c\u9a6c\u8e44\u5185\u7ffb\u8db3\uff0c\u8179\u80a1\u6c9f\u759d\u548c\u9690\u777e (\u4ec5\u9650\u7537\u7ae5)\u3002<\/p>\n


<\/p>\n

\u4fe1\u606f\u6765\u6e90\uff1a\u7531 2 \u4f4d\u8bc4\u5ba1\u5458\u72ec\u7acb\u4ece MEDLINE\uff0cEMBASE \u548c Cochrane CENTRAL \u4e2d\u7b5b\u9009 2015 \u5e74 12 \u6708 15 \u65e5\u4e4b\u524d\u7684\u7b26\u5408\u5165\u9009\u6807\u51c6\u7684\u6240\u6709\u6807\u9898\/\u6458\u8981\u548c\u5168\u6587\u6587\u732e\u3002\u5171\u68c0\u7d22\u51fa 5305 \u7bc7\u6807\u9898\u548c\u6458\u8981\uff0c642 \u7bc7\u53ef\u80fd\u76f8\u5173\u7684\u5168\u6587\u6587\u7ae0\u548c 17 \u7bc7\u6765\u81ea\u626b\u63cf\u53c2\u8003\u6587\u732e\u7684\u7814\u7a76\uff0c\u7ecf\u7b5b\u9009\uff0c\u5171 96 \u9879\u7814\u7a76\u7b26\u5408\u6761\u4ef6 (58461 \u4f8b\u60a3\u8005)\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8bc4\u4f30\u7ed3\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u603b\u4f53\u4e3b\u8981\u5148\u5929\u6027\u7578\u5f62 (CM)<\/span>
<\/p>\n

\u6240\u6709\u7814\u7a76\u4e2d\uff0c\u5bf9\u7167\u7ec4 (\u672a\u66b4\u9732\u4e8e AED) \u4e3b\u8981 CM \u7684\u57fa\u7ebf\u98ce\u9669 (\u4e2d\u4f4d\u6570) \u4e3a 0.026\u3002\u603b\u4f53\u4e3b\u8981 CM \u7684\u7f51\u7edc\u835f\u8403\u5206\u6790\u5305\u62ec 75 \u9879\u961f\u5217\u7814\u7a76\uff0c2 \u9879\u75c5\u4f8b\u5bf9\u7167\u7814\u7a76\u548c 1 \u9879 RCT\uff0c\u5171 35016 \u4f8b\u60a3\u8005\uff0c47 \u7ec4 AEDs+\u5bf9\u7167\u7ec4\uff0c\u5176\u4e2d\u6709 15% \u7684\u7814\u7a76\u4e24\u4e24\u6bd4\u8f83\u8fbe\u5230\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u6027\u5dee\u5f02 (\u56fe 2)\u3002<\/span>
<\/p>\n


<\/p>\n

\u56fe 2. \u603b\u4f53\u4e3b\u8981\u5148\u5929\u6027\u7578\u5f62\u7684\u7f51\u7edc\u56fe<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\"\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u7ba1\u7406\u53ca<\/section>\n<\/section>\n<\/section>\n
\n
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<\/p>\n

 <\/span>levet\uff1a\u5de6\u4e59\u62c9\u897f\u5766<\/span>\uff1b<\/span>carbam\uff1a\u5361\u9a6c\u897f\u5e73\uff1b  clobaz\uff1a\u6c2f\u5df4\u5360\uff1b  clonaz\uff1a\u6c2f\u785d\u897f\u6cee\uff1b ethos\uff1a\u4e59\u7425\u80fa\uff1b gabap\uff1a\u52a0\u5df4\u55b7\u4e01\uff1b lamot\uff1a\u62c9\u83ab\u4e09\u55ea\uff1b oxcar\uff1a\u5965\u5361\u897f\u5e73\uff1b pheno\uff1a\u82ef\u5df4\u6bd4\u59a5\uff1b pheny\uff1a\u82ef\u59a5\u82f1\uff1b primid\uff1a\u6251\u75eb\u916e\uff1b topir\uff1a\u6258\u5421\u916f\uff1b valpro\uff1a\u4e19\u620a\u9178\uff1b vigab\uff1a\u6c28\u5df1\u70ef\u9178.<\/span><\/p>\n


<\/p>\n

\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u4ee5\u4e0b AEDs \u5355\u836f\u6cbb\u7597\u7684\u4e3b\u8981 CM \u53d1\u751f\u98ce\u9669\u663e\u8457\u589e\u52a0\uff1a\u5de6\u4e59\u62c9\u897f\u5766 (OR 0.72\uff0c95%CI\uff0c0.43-1.16)<\/span> \uff0c<\/span>\u4e59\u7425\u80fa (OR 3.04; 95%CI\uff0c1.23-7.07)\uff0c\u4e19\u620a\u9178 (OR 2.93; 95%CI\uff0c2.36-3.69)\uff0c\u6258\u5421\u916f (OR 1.90; 95%CI\uff0c1.17-2.97)\uff0c\u82ef\u5df4\u6bd4\u59a5 (OR 1.83; 95%CI\uff0c1.35-2.47)\uff0c\u82ef\u59a5\u82f1 (OR 1.67; 95%C,I\uff0c1.30-2.17) \u548c\u5361\u9a6c\u897f\u5e73 (OR\uff0c1.37; 95% CI\uff0c1.10-1.71)(\u56fe 2)\u3002\u52a0\u5df4\u55b7\u4e01 (OR 1.00,95%CI\uff0c0.47-1.89)\uff0c\u62c9\u83ab\u4e09\u55ea (OR 0.96\uff0c95%CI\uff0c0.72-1.25)\u4ee5\u53ca\u4e5d\u79cd\u591a\u836f\u6cbb\u7597\u56e0\u7f3a\u4e4f\u8db3\u591f\u8bc1\u636e\u672a\u8fbe\u7edf\u8ba1\u5b66\u5dee\u5f02 (\u56fe 3)\u3002<\/span><\/p>\n


<\/p>\n

\u56fe 3. \u4e3b\u8981\u5148\u5929\u6027\u7578\u5f62\u7684\u7f51\u7edc meta \u5206\u6790\u68ee\u6797\u56fe<\/span><\/p>\n

\u65e9\u4ea7<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u7ba1\u7406\u53ca<\/section>\n<\/section>\n<\/section>\n
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<\/p>\n

\u6240\u6709\u7814\u7a76\u4e2d\uff0c\u5bf9\u7167\u7ec4 (\u672a\u66b4\u9732\u4e8e AED) \u65e9\u4ea7\u7684\u57fa\u7ebf\u98ce\u9669 (\u4e2d\u4f4d\u6570) \u4e3a 0.051\u3002\u65e9\u4ea7\u7684\u7f51\u7edc\u835f\u8403\u5206\u6790\u5305\u62ec 17 \u9879\u961f\u5217\u7814\u7a76\uff0c17133 \u540d\u65b0\u751f\u513f\u548c 22 \u7ec4 AEDs+\u5bf9\u7167\u7ec4\uff0c\u5176\u4e2d 5% \u7684\u6bd4\u8f83\u7814\u7a76\u8fbe\u5230\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u6027\u5dee\u5f02\u3002\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u6c2f\u5df4\u5360 (OR 3.42; 95%CI\uff0c1.41-7.92) \u548c\u6251\u75eb\u916e (OR 2.12; 95%CI\uff0c1.01-4.27) \u7684\u65e9\u4ea7\u98ce\u9669\u663e\u8457\u589e\u52a0 (\u56fe 4)\u3002<\/p>\n


<\/p>\n

\u56fe 4. \u65e9\u4ea7\u7684\u7f51\u7edc meta \u5206\u6790\u68ee\u6797\u56fe<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u7ba1\u7406\u53ca<\/section>\n<\/section>\n<\/section>\n
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<\/section>\n<\/section>\n<\/section>\n
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\u5fc3\u810f\u7578\u5f62<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6240\u6709\u7814\u7a76\u4e2d\uff0c\u5bf9\u7167\u7ec4 (\u672a\u66b4\u9732\u4e8e AED) \u5fc3\u810f\u7578\u5f62\u7684\u57fa\u7ebf\u98ce\u9669 (\u4e2d\u4f4d\u6570) \u4e3a 0.000\u3002\u5fc3\u810f\u7578\u5f62\u7684\u7f51\u7edc\u835f\u8403\u5206\u6790\u5305\u62ec 1 \u9879 RCT\uff0c1 \u4f8b\u75c5\u4f8b\u5bf9\u7167\u548c 49 \u9879\u961f\u5217\u7814\u7a76\uff0c21935 \u4f8b\u75c5\u4f8b\uff0c39 \u7ec4 AEDs+\u5bf9\u7167\u7ec4\uff0c\u5176\u4e2d\u6709 11% \u7684\u6bd4\u8f83\u8fbe\u5230\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u6027\u5dee\u5f02\u3002<\/p>\n


<\/p>\n

\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u5de6\u4e59\u62c9\u897f\u5766 (OR 0.25; 95%CI\uff0c0.03-0.96) \u548c\u62c9\u83ab\u4e09\u55ea (OR 0.55; 95%CI\uff0c0.32-0.95) \u4e0e\u5fc3\u810f\u7578\u5f62\u7684\u76f8\u5173\u6027\u65e0\u663e\u8457\u6027\u5dee\u5f02\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u52a0\u5df4\u55b7\u4e01 (OR 5.98; 95%CI\uff0c1.37-19.73)\uff0c\u5361\u9a6c\u897f\u5e73\u8054\u5408\u82ef\u59a5\u82f1 (OR 6.58\uff1b95%CI\uff0c2.25-18.97)\uff0c\u82ef\u5df4\u6bd4\u59a5\u8054\u5408\u4e19\u620a\u9178 (OR 8.01\uff1b95%CI\uff0c1.17-35.40)\uff0c\u82ef\u59a5\u82f1\u8054\u5408\u4e19\u620a\u9178 (OR 8.88\uff1b95%CI\uff0c2.62-30.65) \u548c\u5361\u9a6c\u897f\u5e73\u8054\u5408\u6c2f\u785d\u897f\u6cee (OR 10.08\uff1b95%CI\uff0c1.40-51.22) \u5fc3\u810f\u7578\u5f62\u7684\u53d1\u751f\u7387\u663e\u8457\u589e\u52a0 (\u56fe 5)\u3002<\/p>\n


<\/p>\n

\u56fe 5. \u5fc3\u810f\u7578\u5f62\u7684\u7f51\u7edc meta \u5206\u6790\u68ee\u6797\u56fe<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u7ba1\u7406\u53ca<\/section>\n<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5c3f\u9053\u4e0b\u88c2<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6240\u6709\u7814\u7a76\u4e2d\uff0c\u5bf9\u7167\u7ec4 (\u672a\u66b4\u9732\u4e8e AED) \u5c3f\u9053\u4e0b\u88c2\u7684\u57fa\u7ebf\u98ce\u9669 (\u4e2d\u4f4d\u6570) \u4e3a 0.000\u3002\u5c3f\u9053\u4e0b\u88c2\u7684\u7f51\u7edc\u835f\u8403\u5206\u6790\u5305\u62ec 1 \u9879 RCT\uff0c1 \u4f8b\u75c5\u4f8b\u5bf9\u7167\u548c 29 \u9879\u961f\u5217\u7814\u7a76\uff0c12365 \u4f8b\u75c5\u4f8b\uff0c31 \u7ec4 AEDs+\u5bf9\u7167\u7ec4\uff0c\u5176\u4e2d 7% \u7684\u6bd4\u8f83\u7814\u7a76\u8fbe\u5230\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002<\/span><\/p>\n


<\/p>\n

\u52a0\u5df4\u55b7\u4e01 (OR 16.54\uff1b95%C I\uff0c2.50-121.70)\uff0c\u6c2f\u785d\u897f\u6cee (OR 6.17; 95%CI\uff0c1.17-24.80)\uff0c\u6251\u75eb\u916e (OR 5.92\uff1b95%CI\uff0c1.01-23.77)\uff0c\u4e19\u620a\u9178 (OR 2.58; 95%CI\uff0c1.24-5.76) \u5c3f\u9053\u4e0b\u88c2\u7684\u53d1\u751f\u7387\u663e\u8457\u589e\u52a0 (\u56fe 6)\u3002<\/span>
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<\/p>\n

\u56fe 6. \u5c3f\u9053\u4e0b\u88c2\u7684\u7f51\u7edc meta \u5206\u6790\u68ee\u6797\u56fe<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\"\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u7ba1\u7406\u53ca<\/section>\n<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n
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\u5507\/\u816d\u88c2<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6240\u6709\u7814\u7a76\u4e2d\uff0c\u5bf9\u7167\u7ec4 (\u672a\u66b4\u9732\u4e8e AED) \u5507\/\u816d\u88c2\u7684\u57fa\u7ebf\u98ce\u9669 (\u4e2d\u4f4d\u6570) \u4e3a 0.000\u3002\u5507\/\u816d\u88c2\u7684\u7f51\u7edc\u835f\u8403\u5206\u6790\u5305\u62ec 1 \u9879 RCT\uff0c1 \u4f8b\u75c5\u4f8b\u5bf9\u7167\u548c 27 \u9879\u961f\u5217\u7814\u7a76\uff0c18987 \u4f8b\u75c5\u4f8b\uff0c33 \u7ec4 AEDs+\u5bf9\u7167\u7ec4\uff0c\u5176\u4e2d 11% \u7684\u6bd4\u8f83\u7814\u7a76\u8fbe\u5230\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002\u5355\u836f\u6cbb\u7597\u7684\u5507\/\u816d\u88c2\u98ce\u9669\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\u7684\u836f\u7269\u5305\u62ec\uff1a\u4e59\u7425\u80fa (OR 22.22; 95% CI\uff0c4.56-87.64)\uff0c\u6251\u75eb\u916e (OR 7.68; 95% CI\uff0c1.41-29.27)\uff0c\u6258\u5421\u916f (OR 6.12; 95% CI\uff0c1.89-19.05)\uff0c\u82ef\u5df4\u6bd4\u59a5 (OR 5.75; 95% CI\uff0c2.41-14.08)\uff0c\u82ef\u59a5\u82f1 (OR 3.11; 95% CI\uff0c1.31-7.72)\uff0c\u4e19\u620a\u9178 (OR 3.26; 95% CI\uff0c1.38-5.58)(\u56fe 7)\u3002<\/span>
<\/p>\n


<\/p>\n

\u56fe 7. \u5507\/\u816d\u88c2\u7684\u7f51\u7edc meta \u5206\u6790\u68ee\u6797\u56fe<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\"\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u7ba1\u7406\u53ca<\/section>\n<\/section>\n<\/section>\n
\n
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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n
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\u9a6c\u8e44\u5185\u7ffb\u8db3<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u6240\u6709\u7814\u7a76\u4e2d\uff0c\u5bf9\u7167\u7ec4 (\u672a\u66b4\u9732\u4e8e AED) \u9a6c\u8e44\u5185\u7ffb\u8db3\u7684\u57fa\u7ebf\u98ce\u9669 (\u4e2d\u4f4d\u6570) \u4e3a 0.000\u3002\u9a6c\u8e44\u5185\u7ffb\u8db3\u7684\u7f51\u7edc\u835f\u8403\u5206\u6790\u5305\u62ec 1 \u9879 RCT\uff0c1 \u4f8b\u75c5\u4f8b\u5bf9\u7167\u548c 21 \u9879\u961f\u5217\u7814\u7a76\uff0c8836 \u4f8b\u75c5\u4f8b\uff0c26 \u7ec4 AEDs+\u5bf9\u7167\u7ec4\uff0c\u5176\u4e2d 7% \u7684\u6bd4\u8f83\u7814\u7a76\u8fbe\u5230\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002\u82ef\u59a5\u82f1 (OR 2.73; 95% CI\uff0c1.13-6.18)\uff0c\u4e19\u620a\u9178 (OR 3.26; 95% CI\uff0c1.43-8.25)\uff0c\u6251\u75eb\u916e (OR 4.71; 95% CI\uff0c1.11-17.24)\uff0c\u4e59\u7425\u80fa (OR 12.99; 95% CI\uff0c1.66-76.39)\uff0c\u5361\u9a6c\u897f\u5e73+\u82ef\u5df4\u6bd4\u59a5 (OR 7.30; 95% CI\uff0c1.29-32.31)\uff0c\u82ef\u5df4\u6bd4\u59a5+\u82ef\u59a5\u82f1+\u6251\u75eb\u916e (OR 13.46; 95% CI\uff0c1.45-132.80) \u9a6c\u8e44\u5185\u7ffb\u8db3\u7684\u53d1\u751f\u7387\u8f83\u5bf9\u7167\u7ec4\u663e\u8457\u589e\u52a0 (\u56fe 8)\u3002<\/span>
<\/p>\n


<\/p>\n

\u56fe 8. \u9a6c\u8e44\u5185\u7ffb\u8db3\u7684\u7f51\u7edc meta \u5206\u6790\u68ee\u6797\u56fe<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\"\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u7ba1\u7406\u53ca<\/section>\n<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
<\/section>\n<\/section>\n<\/section>\n
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\u8179\u80a1\u6c9f\u759d<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u6240\u6709\u7814\u7a76\u4e2d\uff0c\u5bf9\u7167\u7ec4 (\u672a\u66b4\u9732\u4e8e AED) \u8179\u80a1\u6c9f\u759d\u7684\u57fa\u7ebf\u98ce\u9669 (\u4e2d\u4f4d\u6570) \u4e3a 0.000\u3002\u8179\u80a1\u6c9f\u759d\u7684\u7f51\u7edc\u835f\u8403\u5206\u6790\u5305\u62ec 1 \u9879 RCT\uff0c1 \u4f8b\u75c5\u4f8b\u5bf9\u7167\u548c 11 \u9879\u961f\u5217\u7814\u7a76\uff0c12216 \u4f8b\u75c5\u4f8b\uff0c28 \u7ec4 AEDs+\u5bf9\u7167\u7ec4\uff0c\u5176\u4e2d 8% \u7684\u6bd4\u8f83\u7814\u7a76\u8fbe\u5230\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002\u82ef\u5df4\u6bd4\u59a5+\u82ef\u59a5\u82f1 (OR 5.51; 95% CI\uff0c1.25-34.61)\uff0c\u82ef\u5df4\u6bd4\u59a5+\u6251\u75eb\u916e (OR 534.20; 95% CI\uff0c14.39-1.31×105) \u8179\u80a1\u6c9f\u759d\u7684\u53d1\u751f\u7387\u8f83\u5bf9\u7167\u7ec4\u663e\u8457\u589e\u52a0 (\u56fe 9)\u3002<\/p>\n


<\/p>\n

\u56fe 9. \u8179\u80a1\u6c9f\u759d\u7684\u7f51\u7edc meta \u5206\u6790\u68ee\u6797\u56fe<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\"\u598a\u5a20\u671f\u5973\u6027\u766b\u75eb\u7ba1\u7406\u53ca<\/section>\n<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9690\u777e<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6240\u6709\u7814\u7a76\u4e2d\uff0c\u5bf9\u7167\u7ec4 (\u672a\u66b4\u9732\u4e8e AED) \u9690\u777e\u7684\u57fa\u7ebf\u98ce\u9669 (\u4e2d\u4f4d\u6570) \u4e3a 0.000\u3002\u9690\u777e\u7684\u7f51\u7edc\u835f\u8403\u5206\u6790\u5305\u62ec 1 \u9879 RCT\uff0c1 \u4f8b\u75c5\u4f8b\u5bf9\u7167\u548c 8 \u9879\u961f\u5217\u7814\u7a76\uff0c6270 \u4f8b\u7537\u7ae5\uff0c16 \u7ec4 AEDs+\u5bf9\u7167\u7ec4\uff0c\u5176\u4e2d 3% \u7684\u6bd4\u8f83\u7814\u7a76\u8fbe\u5230\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002\u65e0 AEDs \u7684\u9690\u777e\u53d1\u751f\u7387\u8f83\u5bf9\u7167\u7ec4\u663e\u8457\u589e\u52a0 (\u56fe 9)\u3002<\/span>
<\/p>\n


<\/p>\n

\u56fe 9. \u9690\u777e\u7684\u7f51\u7edc meta \u5206\u6790\u68ee\u6797\u56fe<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n
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\u8fd9\u9879\u5927\u91cf\u8bc1\u636e\u7684\u835f\u8403\u5206\u6790\u8868\u660e\uff0c\u62c9\u83ab\u4e09\u55ea\u548c\u5de6\u4e59\u62c9\u897f\u5766\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u4e0d\u589e\u52a0 CM \u98ce\u9669\uff0c\u5e76\u4e14\u53d1\u751f\u5fc3\u810f\u7578\u5f62\u7684\u98ce\u9669\u663e\u8457\u964d\u4f4e\u3002\u76f8\u53cd\uff0c\u4e59\u7425\u80fa\uff0c\u4e19\u620a\u9178\uff0c\u6258\u5421\u916f\uff0c\u82ef\u5df4\u6bd4\u59a5\uff0c\u82ef\u59a5\u82f1\uff0c\u5361\u9a6c\u897f\u5e73\u548c 11 \u79cd\u591a\u836f\u6cbb\u7597\u7684\u7578\u5f62\u98ce\u9669\u589e\u52a0\u3002<\/p>\n


<\/p>\n

\u56e0\u6b64\uff0c\u5f53\u4e3a\u80b2\u9f84\u671f\u5973\u6027\u9996\u6b21\u5904\u65b9 AEDs \u65f6\uff0c\u4ee5\u53ca\u6301\u7eed\u670d\u836f\u7684\u5973\u6027\u8003\u8651\u6000\u5b55\u65f6\uff0c\u5e94\u54a8\u8be2\u836f\u7269\u7684\u81f4\u7578\u98ce\u9669\uff0c\u5982\u4ece\u591a\u836f\u6cbb\u7597\u8f6c\u6362\u4e3a\u98ce\u9669\u8f83\u4f4e\u7684\u5355\u836f\u6cbb\u7597\uff0c\u6216\u907f\u514d\u4f7f\u7528\u4e19\u620a\u9178\u7b49 CM \u98ce\u9669\u9ad8\u7684 AEDs\u3002\u8fd9\u4e9b\u51b3\u7b56\u5fc5\u987b\u4e0e\u63a7\u5236\u53d1\u4f5c\u7684\u9700\u6c42\u76f8\u5e73\u8861\u3002
<\/p>\n


<\/p>\n

\u7f16\u8f91 | \u963f\u7a0b<\/span><\/p>\n


<\/p>\n

\u53c2\u8003\u6587\u732e\uff1aPatel SI, Pennell PB. Management of epilepsy during pregnancy: an update. J Ther Adv Neurol Disord. 2016 Mar;9(2):118-29. <\/p>\n


<\/p>\n

Veroniki AA, et al. Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes. BMC Med. 2017 May 5;15(1):95.<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e13\u5bb6\u5bfc\u8bfb \u672c\u6587\u4ece\u598a\u5a20\u671f\u766b\u75eb\u53d1\u4f5c\u9891\u7387\u5f71\u54cd\u56e0\u7d20\u3001\u598a\u5a20\u671f\u6297\u766b\u75eb\u836f\u7269\uff08AEDs\uff09\u836f\u4ee3\u52a8\u529b\u5b66\u53d8\u5316\u3001\u5b55\u524d\u53f6\u9178\u4f7f\u7528\u3001\u5b55\u4e2d A […]<\/p>\n","protected":false},"author":1,"featured_media":52922,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/52921"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=52921"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/52921\/revisions"}],"predecessor-version":[{"id":52932,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/52921\/revisions\/52932"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/52922"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=52921"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=52921"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=52921"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}