{"id":53042,"date":"2018-09-26T01:00:00","date_gmt":"2018-09-30T01:40:24","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e6%80%8e%e4%b9%88%e7%9c%8b%e5%be%85ido%e6%8a%91%e5%88%b6%e5%89%82%e5%92%8cpd-1%e6%8a%97%e4%bd%93%e4%b9%8b%e9%97%b4%e7%9a%84%e5%85%b3%e7%b3%bb\/"},"modified":"2018-09-30T09:40:25","modified_gmt":"2018-09-30T01:40:25","slug":"%e6%80%8e%e4%b9%88%e7%9c%8b%e5%be%85ido%e6%8a%91%e5%88%b6%e5%89%82%e5%92%8cpd-1%e6%8a%97%e4%bd%93%e4%b9%8b%e9%97%b4%e7%9a%84%e5%85%b3%e7%b3%bb","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/53042\/","title":{"rendered":"\u600e\u4e48\u770b\u5f85IDO\u6291\u5236\u5242\u548cPD-1\u6297\u4f53\u4e4b\u95f4\u7684\u5173\u7cfb"},"content":{"rendered":"
\n
\n
\n
\n

PD-1\u6297\u4f53\u836f\u7269\u7a76\u7adf\u662f\u5982\u4f55\u5f15\u8d77\u5e7f\u5927\u4eba\u6c11\u7fa4\u4f17\u5982\u6b64\u5173\u6ce8\uff1f<\/span><\/span>
<\/p>\n

<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

 \u5168\u65871181\u5b57\uff0c\u7528\u65f62.2\u5206\u949f<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u4f5c\u8005\uff1a\u4e01\u5fc3\u6167<\/span><\/p>\n

\u7b14\u8005\u5bf9\u836f\u54c1\u5927\u6570\u636e\u9886\u57df\u8fd1\u671f\u5927\u4e8b\u4ef6\u4e2d\u5370\u8c61\u6700\u4e3a\u6df1\u523b\u7684\u662f\u670b\u53cb\u5708\u75af\u72c2\u8f6c\u53d1\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53-1 (programmed cell death-1, PD-1) \u6297\u4f53\u836f\u7269\u6b63\u5f0f\u767b\u9646\u4e2d\u56fd\uff0cPD-1\u6297\u4f53\u836f\u7269\u7a76\u7adf\u662f\u5982\u4f55\u5f15\u8d77\u5e7f\u5927\u4eba\u6c11\u7fa4\u4f17\u5982\u6b64\u5173\u6ce8\uff1f<\/span><\/p>\n

\u7b2c\u4e00\u70b9\uff0cPD-1\u6297\u4f53\u836f\u7269\u662f\u6297\u80bf\u7624\u836f\u7269\u53f2\u4e0a\u4e00\u4e2a\u91cc\u7a0b\u7891\u5f0f\u7684\u836f\u7269\uff0c\u662fFDA\u9996\u6b21\u4e0d\u4f9d\u636e\u80bf\u7624\u6765\u6e90\uff0c\u800c\u662f\u4f9d\u636e\u751f\u7269\u6807\u5fd7\u7269\u533a\u5206\u6279\u51c6\u7684\u6297\u80bf\u7624\u7597\u6cd5\u3002\u8ba9\u6211\u4eec\u6765\u4e86\u89e3\u4e00\u4e0bPD-1\u662f\u4ec0\u4e48\uff1fPD-1\u6709PD-L1\u548cPD-L2\u4e24\u79cd\u7ec6\u80de\u819c\u86cb\u767d\u914d\u4f53\u3002PD-L1\u8f83PD-L2\u8868\u8fbe\u8303\u56f4\u5e7f\uff0cPD-L2\u4ec5\u8868\u8fbe\u4e8e\u6d3b\u5316\u7684\u6811\u7a81\u72b6\u7ec6\u80de\uff0c\u800cPD-L1\u5e7f\u6cdb\u8868\u8fbe\u4e8e\u6811\u7a81\u72b6\u7ec6\u80de\u4ee5\u53ca\u8840\u7ba1\u3001\u5fc3\u808c\u3001\u80ce\u76d8\u3001\u80ba\u7b49\u7ec4\u7ec7\u5668\u5b98\u3002\u80bf\u7624\u5fae\u73af\u5883\u53ef\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u9ad8\u8868\u8fbePD-L1\uff0cPD-L1\u901a\u8fc7\u4e0ePD-1\u7ed3\u5408\uff0c\u8d1f\u6027\u8c03\u8282T \u7ec6\u80de\u529f\u80fd\uff0c\u6291\u5236T\u7ec6\u80de\u589e\u6b96\uff0c\u6291\u5236\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u540c\u65f6\u6291\u5236\u7ec6\u80de\u56e0\u5b50\u5982\u767d\u7ec6\u80de\u4ecb\u7d20-2\u3001\u5e72\u6270\u7d20-\u03b3\u7b49\u7684\u4ea7\u751f\uff0c\u4ece\u800c\u4ecb\u5bfc\u80bf\u7624\u7684\u514d\u75ab\u9003\u9038\u3002\u800cPD-1\u6297\u4f53\u963b\u65ad\u4e86\u6b64\u901a\u8def\uff0c\u53ef\u4ee5\u8ba9\u764c\u75c7\u90e8\u4f4d\u7684\u514d\u75ab\u7ec6\u80de\u6b63\u5e38\u5de5\u4f5c\uff0c\u4ece\u800c\u6cbb\u7597\u643a\u5e26\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u9ad8\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u7684\u6210\u4eba\u548c\u513f\u7ae5\u5b9e\u4f53\u7624\u60a3\u8005\u3002<\/span><\/p>\n

\u7b2c\u4e8c\u70b9\uff0c\u4e5f\u662f\u8001\u767e\u59d3\u5173\u6ce8\u5ea6\u6700\u9ad8\u7684\u70b9\uff0c\u836f\u54c1\u4ef7\u683c\u591a\u5c11\uff1f\u80fd\u4e0d\u80fd\u5165\u533b\u4fdd\uff1f\u8fd9\u5757\u5185\u5bb9\u5df2\u7ecf\u6709\u5f88\u591a\u6587\u7ae0\u8bb2\u8ff0\uff0c\u5728\u8fd9\u4e5f\u5c31\u4e0d\u591a\u8d58\u8ff0\u4e86\u3002<\/span><\/p>\n

\u7b2c\u4e09\u70b9\uff0cPD-1\u6297\u4f53\u836f\u7269\u5b8c\u7f8e\u7b26\u5408\u4e86\u8054\u5408\u7528\u836f\u6cbb\u7597\u764c\u75c7\u7684\u5927\u8d8b\u52bf\u3002PD-1\u6297\u4f53\u836f\u7269\u8054\u5408\u5176\u4ed6\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u7269\u5728\u591a\u79cd\u6076\u6027\u80bf\u7624\u7684\u6cbb\u7597\u6548\u679c\u4e2d\u663e\u793a\u5177\u6709\u826f\u597d\u7684\u534f\u540c\u4f5c\u7528\uff0c\u540c\u65f6\u4e5f\u80fd\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u51cf\u5f31PD-1\u6297\u4f53\u836f\u7269\u7684\u8010\u836f\u6027\u3002\u8fd9\u4e5f\u5c31\u4e0d\u5f97\u4e0d\u63d0\u53caIDO\u6291\u5236\u5242\u836f\u7269\u3002\u7b14\u8005\u66fe\u8c03\u67e5\u8fc7BMS(\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d)\u7684BMS-986205\u7247\uff0c\u6b64\u6b3e\u836f\u7269\u5c31\u662f\u4e00\u79cdIDO\u6291\u5236\u5242\u7c7b\u836f\u7269\u3002\u5728\u8c03\u67e5\u8fc7\u7a0b\u4e2d\u610f\u5916\u53d1\u73b0\u4e86IDO\u6291\u5236\u5242\u4e0ePD-1\u6297\u4f53\u540c\u4e3a\u514d\u75ab\u8c03\u8282\u6291\u5236\u5242\u4e4b\u95f4\u5bc6\u5207\u7684\u8054\u7cfb\u3002<\/span><\/p>\n

\u540c\u6837\u8ba9\u6211\u4eec\u6765\u4e86\u89e3\u4e00\u4e0bIDO\u3002\u5432\u54da\u80fa-2,3-\u53cc\u52a0\u6c27\u9176-1 (indoleamine 2,3-dioxy-genase 1, IDO-1)\u662f\u673a\u4f53\u5185\u5929\u7136\u5b58\u5728\u7684\u514d\u75ab\u8c03\u8282\u9176\uff0c\u4e0e\u540c\u5de5\u9176\u5432\u54da\u80fa-2,3-\u53cc\u52a0\u6c27\u9176-2 (indoleamine 2,3-dioxygenase 2, IDO-2)\u3001\u8272\u6c28\u9178-2,3-\u53cc\u52a0\u6c27\u9176 (tryptophan 2,3-dioxygenase, TDO)\u5171\u540c\u7ec4\u6210IDO\u5bb6\u65cf\u3002IDO\u662f\u9664\u809d\u810f\u5916\u552f\u4e00\u80fd\u4ecb\u5bfc\u4eba\u4f53\u8272\u6c28\u9178\u6cbf\u72ac\u5c3f\u6c28\u9178\u9014\u5f84\u964d\u89e3\u7684\u9650\u901f\u9176\uff0c\u548cPD-1\u4e00\u6837\u53ef\u4ee5\u53ef\u4ecb\u5bfc\u591a\u79cd\u80bf\u7624\u7684\u514d\u75ab\u9003\u9038\u3002IDO \u6291\u5236\u5242\u53ef\u6fc0\u6d3bT \u7ec6\u80de\u3001NK \u7ec6\u80de\uff0c\u4e0a\u8c03\u03b3\u5e72\u6270\u7d20\u8868\u8fbe\uff0c\u9006\u8f6cIDO\u8bf1\u5bfc\u7684DC\u7ec6\u80de\u51cb\u4ea1\u3002<\/span><\/p>\n

\u6297PD-1\u836f\u7269\u5355\u836f\u6cbb\u7597\u7684DCR\u7ea6\u4e3a70%\uff0c\u610f\u5473\u7740\u5c06\u8fd130%\u7684\u60a3\u8005\u5bf9\u6297PD-1 \u5355\u836f\u65e0\u53cd\u5e94\uff0c\u800c\u8054\u5408\u4f7f\u7528IDO\u7c7b\u6291\u5236\u5242\u836f\u7269\u8fd9\u79cd\u805a\u7126\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u7684\u9776\u5411\u7597\u6cd5\uff0c\u80fd\u4f7f\u6cbb\u7597\u7684\u6210\u529f\u7387\u66f4\u9ad8\u3002\u5176\u4e2d\u6700\u5177\u4ee3\u8868\u6027\u7684\u836f\u7269\u662fepacadostat\u2014\u2014\u7b2c\u4e00\u4e2a\u4e0ePD-1\u6297\u4f53\u8054\u5408\u6cbb\u7597\u5b9e\u4f53\u7624\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684IDO \u6291\u5236\u5242\u30022016\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u5e74\u4f1a\uff08ESMO\uff09\u4e2depacadostat\u4e0ePD-1\u6297\u4f53pembrolizumab\u8054\u5408\u7528\u836f\u2160~\u2161\u671f\u7814\u7a76\u4e2d\u5305\u542b\u4e8656\u4f8b\u665a\u671f\u6076\u6027\u80bf\u7624\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec36\u4f8b\u6076\u6027\u9ed1\u8272\u7d20\u7624\uff0c20\u4f8b\u80be\u764c\uff0c18\u4f8b\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002\u5b89\u5168\u6027\u5206\u6790\u663e\u793a\u6b64\u8054\u5408\u7528\u836f\u8010\u53d7\u826f\u597d\uff0c\u6ca1\u6709\u89c2\u5bdf\u52304\u7ea7\u62164\u7ea7\u4ee5\u4e0a\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002\u5176\u4e2d36\u4f8b\u6076\u6027\u9ed1\u7d20\u7624\u60a3\u8005\u6570\u636e\u7edf\u8ba1\u5206\u6790\u663e\u793a\uff0c\u5176\u603b\u4f53\u75be\u75c5\u63a7\u5236\u7387\u4e3a74%\uff0c\u603b\u4f53\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a53%\uff0c\u5176\u4e2d26%\u7684\u60a3\u8005\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff0c32%\u60a3\u8005\u8fbe\u90e8\u5206\u7f13\u89e3\u3002\u867d\u7136\u9ed8\u6c99\u4e1c\u5728epacadostat III\u671f\u4e34\u5e8a\u4e2d\u5931\u8d25\uff0c\u4f46IDO\u6291\u5236\u5242\u8054\u5408PD-1\u6297\u4f53\u4ecd\u4e3a\u9006\u8f6c\u514d\u75ab\u6cbb\u7597\u8010\u836f\u63d0\u4f9b\u4e86\u4e00\u79cd\u5d2d\u65b0\u7684\u9ad8\u6548\u5b89\u5168\u7684\u4e34\u5e8a\u6cbb\u7597\u6a21\u5f0f\u3002<\/span><\/p>\n

\u671f\u5f85BMS(\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d)\u3001Roche(\u7f57\u6c0f)\u3001\u4e0a\u6d77\u8bfa\u534e\u8d38\u6613\u6709\u9650\u516c\u53f8\u53ca\u5176\u4ed6\u56fd\u5185\u836f\u7269\u7814\u53d1\u516c\u53f8\u80fd\u5728IDO\u6291\u5236\u5242\u548cPD-1\u6297\u4f53\u8054\u5408\u7528\u836f\u65b9\u9762\u7684\u7814\u7a76\u6709\u6240\u8fdb\u5c55\uff0c\u4e3a\u5b9e\u4f53\u7624\u60a3\u8005\u5e26\u6765\u798f\u97f3\u3002<\/span><\/p>\n

\"\u600e\u4e48\u770b\u5f85IDO\u6291\u5236\u5242\u548cPD-1\u6297\u4f53\u4e4b\u95f4\u7684\u5173\u7cfb\"<\/p>\n

\"\u600e\u4e48\u770b\u5f85IDO\u6291\u5236\u5242\u548cPD-1\u6297\u4f53\u4e4b\u95f4\u7684\u5173\u7cfb\"<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

PD-1\u6297\u4f53\u836f\u7269\u7a76\u7adf\u662f\u5982\u4f55\u5f15\u8d77\u5e7f\u5927\u4eba\u6c11\u7fa4\u4f17\u5982\u6b64\u5173\u6ce8\uff1f  \u5168\u65871181\u5b57\uff0c\u7528\u65f62.2\u5206\u949f \u4f5c\u8005\uff1a\u4e01\u5fc3\u6167 […]<\/p>\n","protected":false},"author":1,"featured_media":53043,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/53042"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=53042"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/53042\/revisions"}],"predecessor-version":[{"id":53046,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/53042\/revisions\/53046"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/53043"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=53042"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=53042"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=53042"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}