{"id":53349,"date":"2018-09-27T01:00:00","date_gmt":"2018-09-30T01:43:48","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e5%85%8d%e7%96%ab%e8%82%bf%e7%98%a4%e7%b3%bb%e5%88%97%ef%bc%9aido%e6%8a%91%e5%88%b6%e5%89%82%e6%9c%80%e8%bf%91%e6%80%8e%e6%a0%b7%e4%ba%86%ef%bc%9f\/"},"modified":"2018-09-30T09:43:50","modified_gmt":"2018-09-30T01:43:50","slug":"%e5%85%8d%e7%96%ab%e8%82%bf%e7%98%a4%e7%b3%bb%e5%88%97%ef%bc%9aido%e6%8a%91%e5%88%b6%e5%89%82%e6%9c%80%e8%bf%91%e6%80%8e%e6%a0%b7%e4%ba%86%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/53349\/","title":{"rendered":"\u514d\u75ab\u80bf\u7624\u7cfb\u5217\uff1aIDO\u6291\u5236\u5242\u6700\u8fd1\u600e\u6837\u4e86\uff1f"},"content":{"rendered":"
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\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8<\/span><\/p>\n


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[\u6570\u636e\u6765\u6e90\uff1aDatamonitor Healthcare\u00ae \/ Biomedtracker\u00ae \/  Medtrack\u00ae \/ <\/span>Pharmaprojects\u00ae \/ Citeline\u00ae \/ Trialtrove\u00ae\uff0c Informa | Pharma Intelligence]<\/span>
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\u6674\u5929\u9739\u96f3 – Incyte\u7684Epacadostat<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2018\u5e744\u67086\u65e5\u53d1\u5e03\u7684ECHO-301\/KEYNOTE-252\u7b2cIII\u9636\u6bb5\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u662fIDO\u4e16\u754c\u7684\u6674\u5929\u9739\u96f3\u3002E<\/span>pacadostat<\/span>\u4e0eKeytruda \u8054\u7528\u4e8e\u9ed1\u7d20\u7624\u6cbb\u7597<\/span>\u7684\u7b2cIII\u9636\u6bb5\u4e34\u5e8a\u8bd5\u9a8c\u672a\u8fbe\u4e3b\u8981\u7ec8\u70b9\u3002\u5728Incyte\u6295\u8d44\u8005\u7535\u8bdd\u4f1a\u8bae\u671f\u95f4\uff0c\u7ba1\u7406\u5c42\u5ba3\u5e03\u5176\u8bd5<\/span>\u9a8c\u7684PFS\u7684\u98ce\u9669\u6bd4\uff08HR\uff09\u4e3a1.00\uff0cOS\u4e3a1.13\uff0c\u4e0eKeytruda <\/span>\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u8be5\u7814\u7a76\u5e76\u672a\u8fbe\u5230\u6539\u5584PFS\u7684\u4e3b\u8981\u7ec8\u70b9\u3002 \u8be5\u7814\u7a76\u7684OS\uff08\u7b2c\u4e8c\u4e3b\u8981\u7ec8\u70b9\uff09\u4e5f\u8fbe\u4e0d\u5230\u7edf\u8ba1\u5b66\u7684\u663e\u8457\u6027<\/span>\u3002\u4e0b\u4e00\u6b65\uff0cIncyte\u4f1a\u4ece\u65b0\u627e\u751f\u7269\u6807\u8bb0\u7269\uff0c\u5e0c\u671b\u53ef\u4ee5\u5206\u6790ECHO-301\/KEYNOTE-252<\/span>\u7684\u7ed3\u679c\u3002<\/span>Incyte\u516c\u53f8\u7684\u80a1\u7968\u4ef7\u683c\u5728\u53d1\u5e03\u5f53\u5929\u4ece83\u7f8e\u5143\u4e0b\u8dcc\u523064\u7f8e\u5143\u3002Incyte\u6839\u636eECHO-301\u7684\u7ed3\u679c\u505a\u4ee5\u4e0b\u51b3\u5b9a\uff1a<\/span><\/p>\n


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\u2022\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9dBMS\uff08Nivolumab <\/span>\uff09\u7684\u5408\u4f5c\uff1a\u505c\u6b62\u80ba\u764c\uff0c\u5934\u9888\u764c\u7684\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c<\/p>\n


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\u2022\u963f\u65af\u5229\u5eb7\u5236\u836fAZ\uff08Durvalumab\uff09\u7684\u5408\u4f5c\uff1a\u6709\u5173\u80ba\u764c\u7684\u5173\u952e\u8bd5\u9a8c\u5c06\u4e0d\u4f1a\u542f\u52a8<\/p>\n


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\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u81f3\u4eca\u6709\u5173Epacadostat\u4e0eKeytruda \u8054\u7528\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e00\u5171\u670929\u4e2a\uff0c\u4f46\u5728\u5f00\u5c55\u6709706\u4f4d\u9ed1\u7d20\u7624\u60a3\u8005\u7684\u7b2cIII\u9636\u6bb5\u7684ECHO-301\/KEYNOTE-252\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u524d\uff082016\u5e746\u670822\u65e5\uff09\uff0c\u53ea\u8fdb\u884c\u8fc7\u4e00\u4e2a\u7b2cI\/II\u9636\u6bb5\u7684ECHO-202\/KEYNOTE-037\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u572828\u4f4d\u53d7\u8bd5\u8005\u4e2d\uff0c\u53ea\u670911\u4f4d\u662f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002\u5229\u7528Trialtrove\u00ae<\/span> \u5206\u6790\u6709\u5173Epacadostat<\/span>\u51c6\u5907\u5f00\u5c55\uff08Planned\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u7533\u529e\u8005\uff0c\u5f53\u4e2d\u5df2\u7ecf\u4e0d\u89c1\u9ed8\u514b\u3001\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u3001\u963f\u65af\u5229\u5eb7\u5236\u836f\u7b49\u7814\u53d1<\/span>PD-1\/PD-L1\u6291\u5236\u5242\u4e4b\u5927\u578b\u836f\u4f01\u7684\u8e2a\u5f71\uff08\u56fe\u4e00\uff09\u3002<\/p>\n


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\u56fe\u4e00\uff1a\u6709\u5173Epacasostat \u51c6\u5907\u5f00\u5c55\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u7533\u529e\u8005 [\u6765\u6e90: Trialtrove\u00ae]<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u514d\u75ab\u80bf\u7624\u7cfb\u5217\uff1aIDO\u6291\u5236\u5242\u6700\u8fd1\u600e\u6837\u4e86\uff1f\"<\/section>\n<\/section>\n<\/section>\n
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\u6b83\u53ca\u6c60\u9c7c – \u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u7684BMS-986205<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2015\u5e742\u6708\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u4ee512.5\u4ebf\u7f8e\u5143\u4eceFlexus Biosciences Inc.\u83b7\u5f97\u5f53\u65f6\u8fd8\u5728\u4e34\u5e8a\u524d\u9636\u6bb5\u7684IDO\u6291\u5236\u5242\uff08BMS-986205\uff09\uff0c\u9884\u9644\u91d1\u66f4\u9ad8\u8fbe8\u4ebf\u7f8e\u5143\u3002BMS-986205\u66fe\u88ab\u5b9a\u4f4d\u4e3aBest-in-class\uff0c\u56e0\u4e3aEpacadostat\u4e0eIndoximod\u6bcf\u5929\u8981\u7ed9\u836f\u4e24\u6b21\uff0c\u4f46BMS-986205\u53ea\u9700\u6bcf\u5929\u8981\u7ed9\u836f<\/span>\u4e00\u6b21\u3002\u4f462018\u5e744\u6708\u5e95\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u5ba3\u5e03\u7ec8\u6b62\u5927\u90e8\u5206\u6709\u5173BMS-986205\u4e0eOpdivo \u8054\u7528\u7684\u7b2cIII\u9636\u6bb5\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u867d\u7136\u6709\u5173\u9ed1\u8272\u7d20\u7624\u7684\u7b2cIII\u9636\u6bb5<\/span>\u7814\u7a76\u8fd8\u5728\u8fdb\u884c\u4e2d\uff0c\u4f46\u5df2\u7ecf\u4e0d\u518d\u62db\u52df\u53d7\u8bd5\u8005\uff08NCT03329846\uff09\u3002\u73b0\u6b63\u8fdb\u884c\u4e2d\uff08Open\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff08\u56fe\u4e8c\uff09<\/span>\uff0c\u5927\u90e8\u5206\u90fd\u662fBMS-986205<\/span>\u4e0eBMS\u65d7\u4e0b\u7684\u836f\u7269\u8054\u7528\u4e4b\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u800c\u4e14\u53ea\u662f\u5904\u4e8eI\/II\u9636\u6bb5\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\u6709\u5173BMS-986205\u4e0eBacille Calmette-Guerinvaccine\uff08BCG\u75ab\u82d7\uff09\u8054\u7528\u7684\u591a\u81c2\u4e34\u5e8a\u8bd5\u9a8c\u662f\u57282018\u5e745\u670825\u65e5\u624d\u5f00\u59cb\u7684\uff0c\u5f53\u4e2d\u7b2c\u4e09\u548c\u7b2c\u56db\u8bd5\u9a8c\u7ec4\u5206\u522b\u6d4b\u8bd5Opivo + BMS-896205\u548cOpdivo + BMS-986205 + BCG\u75ab\u82d7\u5bf9\u8180\u80f1\u764c\u6cbb\u7597\u7684\u7597\u6548\uff0c\u9884\u671f\u8bd5\u9a8c\u7ec8\u6b62\u65e5\u671f\u4e3a2022\u5e741\u67084\u65e5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fe\u4e8c\uff1a\u5f00\u5c55\u4e2d\u7684BMS-986205\u4e34\u5e8a\u7814\u7a76[\u6765\u6e90: Trialtrove\u00ae]<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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NewLink\u7684Indoximod\u662f\u4e0e\u4f17\u4e0d\u540c\u5417\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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NewLink\u4e00\u76f4\u5f3a\u8c03Indoximod\u7684\u4f5c\u7528\u673a\u5236\u548c\u4f4d\u70b9\u4e0e\u5176\u4ed6IDO\u6291\u5236\u5242\u4e0d\u540c\uff0c\u4f462018\u5e745\u67084\u65e5\u516c\u5e03\u7684\u4fe1\u606f\u663e\u793a\u672c\u6765\u8ba1\u5212\u8fdb\u884c\u7684\u7b2cII\u9636\u6bb5\u6709\u5173 Indoximod \u4e0e Imfinzi\u8054\u7528\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u4e0d\u518d\u7ee7\u7eed\u3002<\/p>\n


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NewLink\u5728\u4eca\u5e74\u7684ASCO\u53d1\u5e03\u4e86\u7b2cIb\/II\u9636\u6bb5\uff08NLG2103\uff09\u6709\u5173Indoximod \u4e0eKeytruda\u8054\u7528\u4e8e<\/span>\u9ed1\u8272\u7d20\u7624\u6cbb\u7597\u7684\u9633\u6027\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\uff0c\u8fd9\u662fIDO\u754c\u7684\u597d\u6d88\u606f\u3002\u4f46\u4ed4\u7ec6\u6bd4\u8f83NLG2103\u4e0eIncyte\u7684ECHO-202\u4e34\u5e8a\u8bd5\u9a8c\u53d1\u73b0\uff0c\u8fd9\u4e24\u4e2a\u7b2cII\u9636\u6bb5\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/span>\u6709\u60ca\u4eba\u7684\u76f8\u4f3c\u6027\u3002\u5728ECHO-202\u4e2d\uff0c\u7528Epacadostat\u548cKeytruda\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684ORR\u4e3a56%\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\u4e3a14\uff05\u3002ECHO-202\u548cNLG2103\u7684\u4e2d\u4f4dPFS\u540c\u4e3a12.4\u4e2a\u6708\u3002\u4f46\u968f\u7740Epacadostat\u8fdb\u5165\u7b2cIII\u9636\u6bb5\u7684ECHO-301\u8bd5\u9a8c\uff0cORR\u964d\u81f334.2\uff05\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\u4e3a4\uff05\uff0c\u4e2d\u4f4dPFS\u4e3a4.7\u4e2a\u6708\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\u5728NLG2103\u4e2d\uff0cPD-L1\u9634\u6027\u961f\u5217\u5bf9Indoximod<\/span>\u7684\u53cd\u5e94\u7387\u53cd\u800c\u66f4\u9ad8\u3002<\/p>\n


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\u8f89\u745e\u4e00\u65e9\u9000\u8fd8IDO\u8d44\u4ea7\uff08EOS200271\uff09\u7ed9 iTeos<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2014\u5e7412\u67088\u65e5\uff0c\u8f89\u745e\u4ece\u6bd4\u5229\u65f6\u751f\u7269\u6280\u672f\u516c\u53f8iTeos Therapeutics SA\u83b7\u5f97EOS200271\u3002\u53ef\u60dc\uff0c2018\u5e741\u67084\u65e5\u516c\u5e03\u7684\u7b2cI\u671f\u4e34\u5e8a\u7ed3\u679c\u663e\u793a\uff0c\u5728\u6700\u9ad8\u5242\u91cf(500mg)\u4e4b\u4e0b\u4e5f\u6ca1\u6709\u8fbe\u5230\u529f\u6548\uff0c\u540c\u65f6\u8f89\u745e\u4e0eiTeos\u7ec8\u6b62\u5408\u4f5c\u3002<\/p>\n


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\u4eca\u5e746\u670820\u65e5\uff0ciTeos\u53d6\u5f97MPM Capital\uff0c \u901a\u548c\u6bd3\u627f\u7b497500\u4e07\u7f8e\u91d1\u7684B\u8f6e\u878d\u8d44\u540e\uff0c\u516c\u5e03\u4f1a\u628a\u7814\u53d1\u91cd\u70b9\u653e\u5728EOS100850\uff0c\u817a\u82f7A2A \u53d7\u4f53\u62ee\u6297\u5242\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2014\u5e7410\u670820\u65e5\u7f57\u6c0f<\/span>\u4e0eNewLink Genetics\u516c\u53f8\u8fbe\u6210\u5168\u7403\u7684\u8bb8\u53ef\u534f\u8bae\uff0c\u7f57\u6c0f\u5411NewLink\u652f\u4ed81.5\u4ebf\u7f8e\u5143\uff0c\u7528\u4e8e\u5f00\u53d1GDC-0919\u548c\u5176\u4ed6IDO\/TDO \u6291\u5236\u5242\u3002\u4f46\u53bb\u5e745\u670817\u65e5\u7684ASCO\u4e0a\u53d1\u5e03\u7684\u7ed3\u679c\u4ee4\u4eba\u5931\u671b\uff1a Ib\u671f\u7814\u7a76\u7684\u53d7\u8bd5\u4eba\u6570\u591a\u8fbe305\u4eba\uff0c\u4f46ASCO\u7684\u6570\u636e\u4ec5\u53d1\u5e03\u90e8\u5206\uff08n = 45\uff09\u6570\u636e\uff0c\u6458\u8981\u4e2d\u663e\u793aORR\u76f8\u5bf9\u8f83\u4f4e\uff08<\/span>9\uff05\uff09<\/span>\uff0c\u4f46\u6ca1\u6709\u5176\u4ed6\u7ec6\u8282\u3002\u540c\u5e74 6\u67086\u65e5\uff0c\u7f57\u6c0f\u9000\u51fa\u4e0eNewLink\u7684\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8 [\u6570\u636e\u6765\u6e90\uff1aDatamonitor He […]<\/p>\n","protected":false},"author":1,"featured_media":53350,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/53349"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=53349"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/53349\/revisions"}],"predecessor-version":[{"id":53355,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/53349\/revisions\/53355"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/53350"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=53349"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=53349"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=53349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}