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CAR-T\u4e3b\u8981\u7684\u6bd2\u526f\u4f5c\u7528\u662f\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\uff0c\u795e\u7ecf\u6bd2\u6027\u548cB\u7ec6\u80de\u7f3a\u5931\u3002\u5728\u4e8c\u9662CAR-T\u4e34\u5e8a\u8bd5\u9a8c\u7684\u77e5\u60c5\u540c\u610f\u4e66\u4e2d\uff0c\u5217\u660e\u7684\u6bd2\u526f\u4f5c\u7528\u4e3b\u8981\u75c7\u72b6\u8868\u73b0\u662f\u53d1\u70e7\u3001\u808c\u8089\u9178\u75db\u548c\u6076\u5fc3\uff0c\u4e25\u91cd\u7684\u8fd8\u4f1a\u51fa\u73b0\u4f4e\u8840\u538b\u3001\u6bdb\u7ec6\u8840\u7ba1\u6e17\u6f0f\u548c\u7f3a\u6c27\uff0c\u4ea7\u751f\u5e7b\u89c9\u3001\u610f\u8bc6\u6a21\u7cca\u548c\u9ad8\u70e7\u5f15\u53d1\u7684\u8c35\u5984\u7b49\u5176\u4ed6\u6bd2\u6027\u53cd\u5e94\u3002<\/span><\/p>\n


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\u300a\u8d22\u7ecf\u300b\u8bb0\u8005\u5c31\u738b\u5fd7\u6167\u662f\u5426\u53d1\u751f\u4e86\u6bd2\u526f\u4f5c\u7528\u4e00\u4e8b\u5411\u4e3b\u6cbb\u533b\u751f\u6c42\u8bc1\uff0c\u66f9\u6c5f\u89e3\u91ca\u79f0\uff0c\u201c\u786e\u5b9e\u51fa\u73b0\u8fc7\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\uff0c\u6211\u4eec\u4e5f\u53ca\u65f6\u8fdb\u884c\u836f\u7269\u6cbb\u7597\uff0c\u4f46\u4e0d\u662f\u81f4\u6b7b\u539f\u56e0\u3002\u201d<\/span><\/strong><\/p>\n


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\u535e\u79c0\u82b3\u4e0d\u8ba4\u53ef\u8fd9\u4e00\u8bf4\u6cd5\u30026\u670812\u65e5\u5979\u5c06\u4e8c\u9662\u544a\u4e0a\u5f90\u5dde\u5e02\u6cc9\u5c71\u533a\u4eba\u6c11\u6cd5\u9662\uff0c\u5728\u8d77\u8bc9\u4e66\u4e2d\u5c06\u77db\u5934\u76f4\u63a5\u6307\u5411\u6b64\u6b21CAR-T\u6cbb\u7597\u7684\u5408\u6cd5\u6027\uff0c\u201c\u6211\u4eec\u6ca1\u6709\u89c1\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\u77e5\u60c5\u540c\u610f\u4e66\u3002\u201d\u539f\u544a\u65b9\u8868\u793a\u3002<\/strong><\/span><\/p>\n


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\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c2017\u5e7412\u6708\u738b\u5fd7\u6167\u5c31\u4ee5\u63a5\u53d7CAR-T\u6cbb\u7597\u4e3a\u76ee\u7684\u4f4f\u8fdb\u4e8c\u9662\uff0c\u4e0d\u8fc7\u76f4\u52302018\u5e742\u670828\u65e5\uff0c\u738b\u5fd7\u6167\u8f93\u5165CAR-T\u7ec6\u80de\u7684\u5f53\u5929\u624d\u7b7e\u7f72\u4e34\u5e8a\u8bd5\u9a8c\u77e5\u60c5\u540c\u610f\u4e66\u3002<\/span><\/strong><\/p>\n


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\u9996\u6b21\u5165\u9662\u540e\uff0c\u7531\u4e8e\u738b\u5fd7\u6167\u7684\u8eab\u4f53\u72b6\u6001\u8fd8\u4e0d\u9002\u5b9c\u63d0\u53d6\u7ec6\u80de\uff0c\u4ecd\u9700\u6cbb\u7597\u8c03\u6574\u3002\u4e8c\u9662\u7684CAR-T\u7ec6\u80de\u5236\u5907\u662f\u514d\u8d39\u7684\uff0c\u4f46\u65e5\u5e38\u68c0\u67e5\u3001\u6cbb\u7597\u7684\u5f00\u9500\u8981\u6bd4\u76d0\u57ce\u5e02\u533b\u9662\u9ad8\u51fa\u4e0d\u5c11\uff0c\u56e0\u6b64\u4f4f\u9662\u4e0d\u5230\u4e00\u5468\u738b\u5fd7\u6167\u51fa\u9662\u8fd4\u56de\u8001\u5bb6\u8c03\u6574\u8eab\u4f53\u3002<\/span><\/p>\n


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\u62db\u52dfCAR-T\u4e34\u5e8a\u8bd5\u9a8c\u60a3\u8005\u7684\u5ba3\u4f20\u6d77\u62a5\uff0c\u5c31\u7acb\u5728\u4e8c\u9662\u8840\u6db2\u79d1\u503c\u73ed\u533b\u751f\u529e\u516c\u5ba4\u7684\u65c1\u8fb9\u3002\u66f9\u6c5f\u544a\u8bc9\u300a\u8d22\u7ecf\u300b\u8bb0\u8005\uff0c\u5728\u7b7e\u77e5\u60c5\u540c\u610f\u4e66\u4e4b\u524d\uff0c\u6211\u662f\u544a\u8bc9\u8fc7\u4ed6\u4eec\u8fd9\u662f\u4e34\u5e8a\u8bd5\u9a8c\u7684\uff0c\u800c\u4e14\u591a\u6b21\u8bb2\u8fc7\u53ef\u80fd\u4f1a\u6709\u5404\u79cd\u5e76\u53d1\u75c7\u7684\u98ce\u9669\uff0c\u7a0b\u5e8f\u4e0a\u53ea\u8981\u5728\u8f93\u5165\u7ec6\u80de\u4e4b\u524d\u8ba9\u5979\u7b7e\u5b57\u5c31\u53ef\u4ee5\u3002<\/span><\/p>\n


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\u591a\u4f4d\u53c2\u4e0e\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e1a\u5185\u4eba\u58eb\u544a\u8bc9\u300a\u8d22\u7ecf\u300b\u8bb0\u8005\uff0c\u77e5\u60c5\u540c\u610f\u4e66\u5e94\u5f53\u5728\u786e\u5b9a\u5165\u7ec4\u3001\u4e34\u5e8a\u8bd5\u9a8c\u5f00\u59cb\u4e4b\u524d\u5c31\u7b7e\u8ba2\u597d\u3002<\/span><\/strong><\/p>\n


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\u77e5\u60c5\u540c\u610f\u4e66\u4e2d\u5bf9\u4e8eCAR-T\u7684\u4ecb\u7ecd\u4e3a\uff0c2013\u5e74\u7684\u80bf\u7624\u5b66\u6700\u5927\u6210\u5c31\uff0c\u5728\u590d\u53d1\u3001\u96be\u6cbb\u6027\u6025\u6027\u6dcb\u5df4\u767d\u8840\u75c5\u6cbb\u7597\u4e2d\u8fbe\u5230\u4e86\u8d85\u8fc790%\u7684\u5b8c\u5168\u7f13\u89e3\u7387\uff0c\u73b0\u5728\u8fd9\u4e00\u4ee3\u8868\u56fd\u9645\u6700\u524d\u6cbf\u548c\u6700\u65b0\u53d1\u5c55\u8d8b\u52bf\u7684\u6280\u672f\u6b63\u5728\u88ab\u63a8\u5e7f\u5230\u5305\u62ec\u5b9e\u4f53\u80bf\u7624\u5728\u5185\u7684\u5404\u79cd\u764c\u75c7\u6cbb\u7597\u7684\u8bd5\u9a8c\u4e2d\u3002<\/span><\/p>\n


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\u8fd9\u4e00\u4ecb\u7ecd\u548c\u5b9e\u9645\u6570\u636e\u7565\u6709\u51fa\u5165\u3002\u66f9\u6c5f\u4ecb\u7ecd\uff0c\u4e8c\u9662\u4ece2015\u5e74\u672b\u5f00\u5c55CAR-T\u9879\u76ee\u4ee5\u6765\uff0c\u7528\u4e8e\u665a\u671f\u767d\u8840\u75c5\u3001\u6dcb\u5df4\u7624\u548c\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u7efc\u5408\u6709\u6548\u7387\u4e3a80%\uff0d90%\uff0c\u800c\u4ec5\u5c31\u738b\u5fd7\u6167\u6240\u60a3\u7684\u6dcb\u5df4\u7624\u6765\u8bf4\uff0c\u6709\u6548\u7387\u572870%\uff0d80%\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\u4e3a40%\uff0d50%\u3002<\/span><\/p>\n


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\u5317\u4eac\u534f\u548c\u533b\u5b66\u9662\u4eba\u6587\u5b66\u9662\u6559\u6388\u5f20\u65b0\u5e86\u5206\u6790\uff0c\u5728\u4e34\u5e8a\u8bd5\u9a8c\u7684\u77e5\u60c5\u540c\u610f\u544a\u77e5\u65f6\uff0c\u4e0d\u5e94\u5e26\u6709\u8bf1\u5bfc\u6027\u7684\u8bed\u53e5\uff0c\u8981\u5ba2\u89c2\u5168\u9762\u5730\u4ecb\u7ecd\u4e34\u5e8a\u8bd5\u9a8c\u7684\u76ee\u7684\u3001\u8fc7\u7a0b\u3001\u98ce\u9669\u548c\u53d7\u76ca\u7b49\u3002<\/span><\/strong>\u4e0d\u5e94\u4f7f\u7528\u201c\u4ee3\u8868\u56fd\u9645\u6700\u524d\u6cbf\u548c\u6700\u65b0\u53d1\u5c55\u8d8b\u52bf\u201d\u6765\u5938\u5927\u7814\u7a76\u7684\u610f\u4e49\u548c\u53ef\u80fd\u7684\u7597\u6548\uff0c\u5c06\u6bd2\u526f\u4f5c\u7528\u8868\u8ff0\u4e3a\u201c\u4f34\u968f\u53cd\u5e94\u201d\u8fd9\u6837\u7684\u8bcd\u8bed\u6765\u9003\u907f\u4f7f\u7528\u201c\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u201d\u7b49\u98ce\u9669\u4fe1\u606f\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u8868\u8ff0\u4f1a\u5bf9\u6f5c\u5728\u53d7\u8bd5\u8005\u4ea7\u751f\u4e0d\u6b63\u5f53\u7684\u5f71\u54cd\uff0c\u8bf1\u4f7f\u4ed6\u4eec\u975e\u81ea\u613f\u5730\u53c2\u4e0e\u8fd9\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n


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\u535e\u79c0\u82b3\u5bf9CAR-T\u7684\u5e0c\u5180\u51e0\u4e4e\u6df9\u6ca1\u4e86\u5979\u5bf9\u98ce\u9669\u7684\u8b66\u60d5\u3002\u524d\u540e\u4e09\u6b21\u4f4f\u8fdb\u4e8c\u9662\uff0c\u535e\u79c0\u82b3\u82b1\u8d39\u7ea617\u4e07\u5143\u3002\u52a0\u4e0a\u4e4b\u524d\u4e00\u5e74\u7684\u8bca\u6cbb\u5316\u7597\uff0c\u5bb6\u4e2d\u8d1f\u503a\u5df2\u8fd130\u4e07\u5143\u3002<\/span><\/p>\n


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\u867d\u7136\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6838\u5fc3\u90e8\u5206CAR-T\u7ec6\u80de\u5236\u5907\u5168\u90e8\u514d\u8d39\uff0c\u4f46\u8d5e\u52a9\u7ecf\u8d39\u5e76\u4e0d\u80fd\u8986\u76d6\u6240\u6709\u8d39\u7528\u3002<\/span><\/strong>\u201cCAR-T\u7ec6\u80de\u5236\u5907\u4e4b\u5916\u7684\u4f4f\u9662\u3001\u8bca\u7597\u8d39\u7528\u662f\u6309\u6b63\u5e38\u6807\u51c6\u6536\u53d6\u7684\u3002\u201d\u5317\u5927\u4eba\u6c11\u533b\u9662\u8840\u6db2\u79d1\u526f\u4e3b\u4efb\u533b\u5e08\u95eb\u6668\u534e\u5411\u300a\u8d22\u7ecf\u300b\u8bb0\u8005\u4ecb\u7ecd\u3002\u4f4f\u9662\u3001\u8bca\u7597\u8d39\u7528\u5728\u5404\u4e34\u5e8a\u8bd5\u9a8c\u673a\u6784\u4e0d\u5c3d\u76f8\u540c\u3002<\/span><\/p>\n


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\u201c\u9664\u4e86\u5fc5\u8981\u7684\u68c0\u67e5\u3001\u5316\u7597\u6536\u8d39\uff0c\u7531\u4e8eCAR-T\u6cbb\u7597\u4ea7\u751f\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u5982\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u7b49\u6cbb\u7597\u3001\u62a2\u6551\u90fd\u662f\u6536\u8d39\u7684\uff0c\u901a\u5e38\u4e00\u4e2a\u7597\u7a0b\u4e0b\u6765\u4e5f\u8981\u5c0f\u5341\u4e07\u5427\u3002\u201d\u6dcb\u5df4\u7624\u4e4b\u5bb6\u521b\u59cb\u4eba\u6d2a\u98de\u544a\u8bc9\u300a\u8d22\u7ecf\u300b\u8bb0\u8005\u3002<\/span><\/p>\n


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\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u751f\u5b58\u8d1f\u62c5\u539f\u672c\u5c31\u4e0d\u4f4e\u3002\u6839\u636e\u6dcb\u5df4\u7624\u4e4b\u5bb6\u60a3\u8005\u7ec4\u7ec7\u516c\u5e03\u7684\u300a\u4e2d\u56fd\u6dcb\u5df4\u7624\u60a3\u8005\u751f\u5b58\u62a5\u544a2017\u300b\u7edf\u8ba1\uff0c\u670939%\u7684\u6dcb\u5df4\u7624\u60a3\u8005\u4e3a\u53ef\u4ee5\u9002\u7528CAR-T\u7684\u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff1b\u670970%\u7684\u60a3\u8005\u4f7f\u7528\u8fc7\u6216\u8005\u6b63\u5728\u4f7f\u7528\u9776\u5411\u6216\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff0c\u5176\u4e2d\u67091%\u7684\u60a3\u8005\u53c2\u4e0e\u8fc7CAR-T\u4e34\u5e8a\u8bd5\u9a8c\u3002\u800c\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\uff0c\u670940%\u7684\u60a3\u8005\u81ea\u8d39\u91d1\u989d\u8d85\u8fc7\u5bb6\u5ead\u5e74\u6536\u5165\u76843\u500d\u3002<\/span><\/p>\n


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CAR-T\u7597\u6cd5\u7684\u4ef7\u683c\u6210\u672c\u786e\u5b9e\u9ad8\u6602\uff0c\u5df2\u5728\u7f8e\u56fd\u4e0a\u5e02\u7684\u4e24\u6b3e\u4ea7\u54c1\u5206\u522b\u552e\u4ef7\u4e3a47.5\u4e07\u7f8e\u5143\u300137.3\u4e07\u7f8e\u5143\uff0c\u5982\u679c\u52a0\u4e0a\u68c0\u67e5\u3001\u4f4f\u9662\u7b49\u8d39\u7528\uff0c\u6bcf\u540d\u60a3\u8005\u82b1\u8d39\u5c06\u8fbe\u523080\u4e07\u81f3150\u4e07\u7f8e\u5143\u3002<\/span><\/p>\n


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\u76f8\u6bd4\u800c\u8a00\uff0c\u5341\u51e0\u4e07\u5143\u80fd\u53c2\u4e0eCAR-T\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5bf9\u4e0d\u5c11\u4eba\u6765\u8bf4\u4e5f\u662f\u96be\u5f97\u7684\u673a\u4f1a\u3002\u4e14\u5728\u56fd\u5185\uff0c\u4e0d\u5c11\u7531\u4f01\u4e1a\u4e3b\u5bfc\u7684CAR-T\u4e34\u5e8a\u8bd5\u9a8c\u51e0\u8fd1\u514d\u8d39\u3002<\/span><\/strong><\/p>\n


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\u201c\u6211\u4eec\u4e0d\u6536\u53d6\u4efb\u4f55\u8d39\u7528\uff0c\u533b\u9662\u4e5f\u53ea\u6536\u6700\u57fa\u7840\u7684\u5e8a\u4f4d\u8d39\u7b49\uff0c\u4e00\u4e2a\u7597\u7a0b\u4e0b\u6765\u4e0d\u8d85\u8fc71\u4e07\u5143\u3002\u201d\u4e2d\u79d1\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7814\u7a76\u5458\u4e07\u6653\u6625\u5411\u300a\u8d22\u7ecf\u300b\u8bb0\u8005\u4ecb\u7ecd\u3002<\/span><\/p>\n


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\u6709\u7684\u533b\u7597\u673a\u6784\u4f1a\u627f\u62c5\u5305\u62ec\u60a3\u8005\u53c2\u4e0e\u8bd5\u9a8c\u7684\u5f80\u8fd4\u8def\u8d39\u7b49\u4e00\u7cfb\u5217\u8d39\u7528\u3002\u201c\u4f5c\u4e3a\u4e34\u5e8a\u8bd5\u9a8c\u662f\u8981\u5b9a\u671f\u968f\u8bbf\u3001\u68c0\u67e5\uff0c\u5982\u679c\u6ca1\u6709\u7ecf\u8d39\u4fdd\u969c\uff0c\u60a3\u8005\u968f\u65f6\u6709\u53ef\u80fd\u9000\u51fa\u8bd5\u9a8c\uff0c\u540e\u671f\u7684\u8bd5\u9a8c\u6570\u636e\u4e5f\u4e0d\u80fd\u5f97\u5230\u4fdd\u969c\u3002\u201d\u4e00\u4f4d\u4e1a\u5185\u4eba\u58eb\u544a\u8bc9\u300a\u8d22\u7ecf\u300b\u8bb0\u8005\u3002<\/span><\/p>\n


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\u535e\u79c0\u82b3\u8ba4\u4e3a\u4e8c\u9662\u7684\u65e5\u5e38\u6cbb\u7597\u8d39\u7528\u8f83\u9ad8\u3002\u7531\u4e8e\u539f\u544a\u5728\u7b2c\u4e00\u6b21\u5f00\u5ead\u65f6\u4e34\u65f6\u5c06\u8bc9\u8bbc\u8bf7\u6c42\u7684\u8d54\u507f\u91d1\u989d\u75313\u4e07\u5143\u63d0\u5347\u81f3100\u4e07\u5143\uff0c\u4e8c\u9662\u8981\u6c42\u7b54\u8fa9\u51c6\u5907\u671f\uff0c\u6848\u4ef6\u5f53\u5929\u672a\u8fdb\u884c\u4efb\u4f55\u5b9e\u8d28\u6027\u5ba1\u7406\u3002<\/span><\/p>\n


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\u5ba1\u7406\u8be5\u6848\u7684\u5f90\u5dde\u5e02\u6cc9\u5c71\u533a\u4eba\u6c11\u6cd5\u9662\u6cd5\u5b98\u5f20\u65b0\u5efa\u544a\u8bc9\u300a\u8d22\u7ecf\u300b\u8bb0\u8005\uff0c\u5f90\u533b\u9644\u9662\u5728\u7b2c\u4e00\u6b21\u5f00\u5ead\u65f6\u66fe\u8868\u793a\u548c\u89e3\u610f\u5411\uff0c\u4f46\u8d54\u507f\u91d1\u989d\u7684\u7a81\u7136\u53d8\u66f4\uff0c\u4f7f\u5f97\u5176\u4ee3\u7406\u5f8b\u5e08\u63d0\u51fa\u8981\u548c\u533b\u9662\u9886\u5bfc\u5546\u91cf\u3002<\/span><\/strong><\/p>\n


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\u4e0a\u6d77\u5e02\u8054\u5408\u5f8b\u5e08\u4e8b\u52a1\u6240\u5f8b\u5e08\u5362\u610f\u5149\u8868\u793a\uff0c\u786e\u5b9e\u6709\u4e00\u4e9b\u533b\u7597\u673a\u6784\uff0c\u751a\u81f3\u975e\u533b\u7597\u673a\u6784\uff0c\u5047\u501f\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u7684\u4e34\u5e8a\u7814\u7a76\u4e4b\u540d\uff0c\u884c\u4e34\u5e8a\u5e94\u7528\u4e4b\u5b9e\uff0c\u4e25\u91cd\u635f\u5bb3\u60a3\u8005\u5408\u6cd5\u6743\u76ca\u3002<\/span><\/p>\n


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\u4e2d\u56fd\u88c1\u5224\u6587\u4e66\u7f51\u6848\u4f8b\u663e\u793a\uff0c2017\u5e7411\u6708\uff0c\u82cf\u5dde\u4f70\u901a\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u4e0b\u79f0\u201c\u4f70\u901a\u751f\u7269\u201d\uff09\u7ed9\u4e00\u540d\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u8f93\u5165\u4e86CAR-NK\u6cbb\u7597\uff0c\u6574\u4e2a\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u62a5\u4ef735\u4e07\u5143\u5de6\u53f3\uff0c\u540e\u60a3\u8005\u6b7b\u4ea1\u3002\u800c\u8fd9\u5bb6\u516c\u53f8\u5e76\u4e0d\u5177\u5907\u533b\u7597\u8d44\u8d28\uff0c\u4e3b\u8425\u8303\u56f4\u53ea\u662f\u751f\u7269\u6280\u672f\u7684\u7814\u53d1\u53ca\u6280\u672f\u54a8\u8be2\u670d\u52a1\uff1b\u9500\u552e\u975e\u5371\u9669\u5316\u5de5\u4ea7\u54c1\u3001\u5316\u5986\u54c1\uff08\u4f9d\u6cd5\u987b\u7ecf\u6279\u8f6c\u7684\u9879\u76ee\uff0c\u7ecf\u76f8\u5173\u90e8\u95e8\u6279\u51c6\u540e\u65b9\u53ef\u5f00\u5c55\u7ecf\u8425\u6d3b\u52a8\uff09\u3002<\/span><\/p>\n


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\u6c5f\u82cf\u7701\u82cf\u5dde\u5e02\u4e2d\u7ea7\u4eba\u6c11\u6cd5\u9662\u8ba4\u5b9a\uff0c\u867d\u7136\u96be\u4ee5\u8bc1\u660e\u8f93\u5165CAR-NK\u76f4\u63a5\u5bfc\u81f4\u60a3\u8005\u6b7b\u4ea1\uff0c\u4f46\u4f70\u901a\u751f\u7269\u5bf9\u60a3\u8005\u7684\u6b7b\u4ea1\u5b58\u5728\u8fc7\u9519\uff0c\u5e94\u627f\u62c5\u8d54\u507f\u8d23\u4efb\u3002<\/span><\/p>\n


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\u5728\u738b\u5fd7\u6167\u6848\u4e2d\uff0c\u53cc\u65b9\u5bf9\u8fd9\u4e00\u4e34\u5e8a\u8bd5\u9a8c\u5408\u6cd5\u6027\u6709\u5206\u6b67\uff0c\u6e90\u81ea\u4e8e\u53cc\u65b9\u5bf9CAR-T\u5b9a\u4f4d\u7684\u4e0d\u540c\u3002<\/span><\/p>\n


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8\u670823\u65e5\u4e0a\u5348\uff0c\u7b2c\u4e8c\u6b21\u5f00\u5ead\u4e2d\uff0c\u53cc\u65b9\u4e3b\u8981\u77db\u76fe\u805a\u7126\u5728CAR-T\u5230\u5e95\u5c5e\u4e8e\u836f\u54c1\u8fd8\u662f\u6cbb\u7597\u6280\u672f\u4e0a\u3002\u539f\u544a\u65b9\u575a\u6301\u8ba4\u4e3a\uff0cCAR-T\u5df2\u7ecf\u7eb3\u5165\u56fd\u5bb6\u836f\u76d1\u5c40\u7ba1\u7406\uff0c\u5e94\u6309\u7167\u836f\u54c1\u4e34\u5e8a\u8bd5\u9a8c\u7ba1\u7406\u3002\u800c\u4e8c\u9662\u8868\u793a\uff0cCAR-T\u53ea\u662f\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u624b\u6bb5\uff0c\u8fd9\u662f\u4e00\u9879\u79d1\u5b66\u7814\u7a76\u6027\u8d28\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n


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\u539f\u544a\u65b9\u4ecb\u7ecd\uff0c\u76ee\u524d\u6cd5\u9662\u8981\u6c42\u5176\u5411\u56fd\u5bb6\u836f\u76d1\u5c40\u8fdb\u884c\u4e66\u9762\u54a8\u8be2\uff0c\u660e\u786eCAR-T\u4e34\u5e8a\u8bd5\u9a8c\u662f\u5426\u9700\u8981\u836f\u76d1\u5c40\u5ba1\u6279\u540e\u624d\u53ef\u4ee5\u5f00\u5c55\u3002<\/span><\/strong><\/p>\n


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\u5728\u4e2d\u56fd\u8fdb\u884c\u7684CAR-T\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5927\u4f53\u53ef\u5206\u4e3a\u4e24\u7c7b\uff0c\u4e00\u7c7b\u662f\u8ba1\u5212\u7533\u62a5\u836f\u54c1\u7684\u6ce8\u518c\u7c7b\u8bd5\u9a8c\uff0c\u7531\u56fd\u5bb6\u836f\u76d1\u5c40\u5ba1\u6279\uff0c\u5b8c\u5168\u6309\u7167\u836f\u54c1\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5404\u9879\u51c6\u5219\u8fdb\u884c\u3002\u7b2c\u4e8c\u7c7b\uff0c\u5219\u7531\u533b\u9662\u548c\u79d1\u7814\u673a\u6784\u4e3b\u5bfc\u7684\uff0c\u7814\u7a76\u7c7b\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u53ea\u9700\u8981\u83b7\u5f97\u533b\u9662\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u5ba1\u67e5\u5373\u53ef\u8fdb\u884c\u3002<\/span>\u591a\u6570\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8d70\u7684\u662f\u7b2c\u4e8c\u7c7b\u3002<\/span><\/p>\n


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\u65e9\u57282009\u5e74\uff0c\u539f\u536b\u751f\u90e8\u9881\u53d1\u7684\u300a\u533b\u7597\u6280\u672f\u4e34\u5e8a\u5e94\u7528\u7ba1\u7406\u529e\u6cd5\u300b\u5c31\u5c06CAR-T\u5212\u5b9a\u4e3a\u7b2c\u4e09\u7c7b\u533b\u7597\u6280\u672f\uff0c\u4f4d\u5217\u9996\u6279\u5141\u8bb8\u8fdb\u884c\u4e34\u5e8a\u5e94\u7528\u7684\u540d\u5355\u4e4b\u4e0a\uff0c\u7531\u536b\u751f\u90e8\u5ba1\u5b9a\u3002<\/span><\/p>\n


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\u201c\u8fd9\u5c31\u662f\u4e00\u79cd\u6cbb\u7597\u6280\u672f\uff0c\u628a\u7ec6\u80de\u62ff\u51fa\u6765\u52a0\u5de5\u4e00\u4e0b\u518d\u8f93\u5165\u56de\u53bb\uff0c\u5c31\u597d\u50cf\u80c3\u90e8\u624b\u672f\u8fc7\u7a0b\u4e2d\u628a\u80c3\u62ff\u51fa\u4f53\u5916\uff0c\u5904\u7406\u4e00\u4e0b\u518d\u653e\u56de\u53bb\u4e00\u6837\u3002\u201d\u5317\u4eac\u67d0\u4e09\u7ea7\u533b\u9662\u4e00\u540d\u4ece\u4e8bCAR-T\u9879\u76ee\u7684\u533b\u751f\u5bf9\u300a\u8d22\u7ecf\u300b\u8bb0\u8005\u8bf4\u3002<\/span><\/strong><\/p>\n


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\u76f4\u52302013\u5e74\uff0cCAR-T\u7597\u6cd5\u5728\u4e2d\u56fd\u624d\u771f\u6b63\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f46\u5f53\u65f6\u51e0\u4e4e\u5904\u4e8e\u65e0\u5e8f\u72b6\u6001\uff0c\u90e8\u5206\u533b\u9662\u76f4\u63a5\u7528\u4e8e\u4e34\u5e8a\u6cbb\u7597\uff0c\u5373\u4f7f\u662f\u505a\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u4f1a\u6536\u8d39\uff0c\u5305\u62ecCAR-T\u7ec6\u80de\u5236\u5907\u73af\u8282\u3002\u52302015\u5e74\uff0c\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u624d\u88ab\u660e\u4ee4\u7981\u6b62\u4e34\u5e8a\u5e94\u7528\uff0c\u7b2c\u4e09\u7c7b\u533b\u7597\u6280\u672f\u7684\u4e34\u5e8a\u5e94\u7528\u4ece\u5ba1\u6279\u5236\u6539\u4e3a\u5907\u6848\u5236\uff0c\u7136\u800cCAR-T\u5df2\u4ece\u300a\u9650\u5236\u4e34\u5e8a\u5e94\u7528\u7684\u533b\u7597\u6280\u672f\uff082015\u7248\uff09\u300b\u540d\u5355\u4e2d\u88ab\u5254\u9664\u3002<\/span><\/p>\n


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\u81ea\u6b64\uff0cCAR-T\u5b8c\u5168\u505c\u6b62\u4e86\u4e34\u5e8a\u5e94\u7528\uff0c\u53ea\u80fd\u4f5c\u4e3a\u4e34\u5e8a\u8bd5\u9a8c\u5728\u56fd\u5185\u5f00\u5c55\uff0c\u7ec6\u80de\u5236\u5907\u4e5f\u6210\u4e3a\u5fc5\u987b\u514d\u8d39\u7684\u73af\u8282\u3002<\/span><\/p>\n


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\u53ea\u4e0d\u8fc7\uff0c\u8fd9\u4e00\u9636\u6bb5\u5728\u4e2d\u56fd\u5982\u706b\u5982\u837c\u5f00\u5c55\u7684CAR-T\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f9d\u7136\u7f3a\u4e4f\u5ba1\u6838\u4e0e\u6807\u51c6\u3002<\/span><\/strong><\/p>\n


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2017\u5e7410\u6708\uff0c\u539f\u56fd\u5bb6\u98df\u836f\u76d1\u603b\u5c40\u53d1\u5e03\u300a\u836f\u54c1\u6ce8\u518c\u7ba1\u7406\u529e\u6cd5\uff08\u4fee\u8ba2\u7a3f\uff09\u300b\uff0c\u5411\u793e\u4f1a\u5f81\u6c42\u610f\u89c1\u3002\u4fee\u8ba2\u7a3f\u9488\u5bf9\u751f\u7269\u5236\u54c1\u7684\u89c4\u5b9a\u4e2d\uff0c\u4e00\u4e2a\u91cd\u8981\u7684\u53d8\u5316\u662f\uff0c\u7ec6\u80de\u6cbb\u7597\u53ef\u4ee5\u540c\u836f\u54c1\u4e00\u6837\u7533\u62a5\u6ce8\u518c\u3002\u4e0d\u8fc7\uff0c\u8fdf\u8fdf\u672a\u843d\u9524\u5b9a\u97f3\u3002<\/span><\/p>\n


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\u4e24\u4e2a\u6708\u540e\uff0c\u539f\u56fd\u5bb6\u98df\u836f\u76d1\u603b\u5c40\u53c8\u51fa\u53f0\u4e86\u300a\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u7814\u7a76\u4e0e\u8bc4\u4ef7\u6280\u672f\u6307\u5bfc\u539f\u5219\uff08\u8bd5\u884c\uff09\u300b\uff0c\u5bf9\u5176\u9002\u7528\u7684\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u8303\u56f4\u8fdb\u884c\u4e86\u9650\u5b9a\uff0c\u662f\u6307\u7528\u4e8e\u6cbb\u7597\u4eba\u7684\u75be\u75c5\uff0c\u6765\u6e90\u3001\u64cd\u4f5c\u548c\u4e34\u5e8a\u8bd5\u9a8c\u8fc7\u7a0b\u7b26\u5408\u4f26\u7406\u8981\u6c42\uff0c\u6309\u7167\u836f\u54c1\u7ba1\u7406\u76f8\u5173\u6cd5\u89c4\u8fdb\u884c\u7814\u53d1\u548c\u6ce8\u518c\u7533\u62a5\u7684\u4eba\u4f53\u6765\u6e90\u7684\u6d3b\u7ec6\u80de\u4ea7\u54c1\u3002<\/span><\/p>\n


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\u5728\u4e0d\u5c11\u4e1a\u5185\u4eba\u58eb\u770b\u6765\uff0c\u8fd9\u4e00\u6307\u5bfc\u539f\u5219\u7b97\u662f\u660e\u786e\u4e86CAR-T\u8d70\u4e0a\u6309\u7167\u836f\u54c1\u76d1\u7ba1\u7684\u89c4\u8303\u8def\u5f84\uff0c\u800c\u836f\u54c1\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u5fc5\u987b\u7ecf\u8fc7\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\uff0c\u901a\u5e38\u7531\u5236\u836f\u4f01\u4e1a\u7533\u8bf7\u3002<\/span><\/strong>2018\u5e743\u670813\u65e5\uff0c\u5357\u4eac\u4f20\u5947\u751f\u7269\u7684CAR-T\u7597\u6cd5\u83b7\u5f97\u539f\u56fd\u5bb6\u98df\u836f\u76d1\u603b\u5c40\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\uff0c\u6210\u4e3a\u4e2d\u56fd\u9996\u4e2a\u83b7\u6279\u4e34\u5e8a\u8bd5\u9a8c\u7684CAR-T\u7597\u6cd5\u3002<\/span><\/p>\n


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\u5b9e\u9645\u4e0a\uff0c\u5728\u56fd\u9645\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u7f51\u7ad9ClinicalTrials.gov\u4e2d\uff0c\u6709152\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u6765\u81ea\u4e2d\u56fd\u3002\u4f46\u622a\u81f38\u670823\u65e5\uff0c\u4ec5\u670921\u4e2aCAR-T\u7ec6\u80de\u5236\u5242\u4ea7\u54c1\u5411\u56fd\u5bb6\u836f\u76d1\u5c40\u63d0\u4ea4\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u3002\u53ef\u89c1\uff0c\u5927\u90e8\u5206\u7684CAR-T\u4e34\u5e8a\u8bd5\u9a8c\u90fd\u5904\u5728\u81ea\u7531\u53d1\u5c55\u72b6\u6001\u3002<\/span><\/p>\n


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\u4e8c\u9662\u7684\u8bd5\u9a8c\u9879\u76ee\u5df2\u767b\u8bb0\u8fc7\u3002\u66f9\u6c5f\u8ba4\u4e3a\uff0c\u201c\u6211\u4eec\u662f\u79d1\u7814\u6027\u8d28\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u4e0d\u6253\u7b97\u7533\u62a5\u836f\u54c1\uff0c\u6240\u4ee5\u4e5f\u4e0d\u9700\u8981\u6309\u7167\u836f\u54c1\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8981\u6c42\u8fdb\u884c\u3002\u4f5c\u4e3a\u6280\u672f\u7597\u6cd5\u53ea\u9700\u8981\u901a\u8fc7\u9662\u5185\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u5ba1\u6838\u5373\u53ef\u5f00\u5c55\u3002\u201d<\/span><\/p>\n


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\u5728\u7f8e\u56fd\uff0cCAR-T\u7684\u7814\u53d1\u3001\u4e34\u5e8a\u4e0e\u4e0a\u5e02\uff0c\u4e00\u76f4\u662f\u7531\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u8d1f\u8d23\u3002\u201c\u7c7b\u4f3c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u88ab\u79f0\u4e3a\u7814\u7a76\u8005\u53d1\u8d77\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff08Investigator Initial Trial\uff0cIITs\uff09\u3002\u201d\u7f8e\u56fd\u9ad8\u683c\u5229\u534e\u5f8b\u5e08\u4e8b\u52a1\u6240\u521b\u59cb\u5408\u4f19\u4eba\u90d1\u5229\u534e\u5411\u300a\u8d22\u7ecf\u300b\u8bb0\u8005\u4ecb\u7ecd\uff0c\u5982\u679c\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u5728FDA\u5df2\u7ecf\u6709\u76f8\u5e94\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08IND\uff09\uff0c\u90a3\u7814\u7a76\u673a\u6784\u53ea\u9700\u901a\u8fc7\u5185\u90e8\u4f26\u7406\u59d4\u5458\u4f1a\u6279\u51c6\u5373\u53ef\uff1b\u5982\u679cFDA\u8fd8\u8bbe\u6709\u5f00\u653e\u8be5\u65b0\u836f\u7684IND\uff0c\u90a3\u4e48\u7814\u7a76\u673a\u6784\u8981\u5148\u5728FDA\u83b7\u53d6IND\u3002\u5f53\u7136\uff0cIITs\u8fd8\u8981\u7b26\u5408GCP(\u300a\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u8d28\u91cf\u7ba1\u7406\u89c4\u8303\u300b)\u548cGLP\uff08\u300a\u836f\u7269\u975e\u4e34\u5e8a\u7814\u7a76\u8d28\u91cf\u7ba1\u7406\u89c4\u8303\u300b\uff09\u7b49\u3002FDA\u4e5f\u4e13\u95e8\u51fa\u53f0\u4e86\u9488\u5bf9\u7814\u7a76\u8005\u53d1\u8d77\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6307\u5357\u3002<\/span><\/p>\n


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\u201c\u73b0\u5728\u8fd9\u4e48\u591a\u7684CAR-T\u7814\u7a76\u673a\u6784\uff0c\u5927\u591a\u662f\u7814\u7a76\u751f\u7269\u5236\u5242\u7684\uff0c\u5b83\u4eec\u5728\u64cd\u4f5c\u89c4\u8303\u548c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ecf\u9a8c\u4e0a\u90fd\u4e0d\u5982\u836f\u4f01\u3002\u201d\u6d2a\u98de\u8bf4\uff0c\u6bd4\u5982\u836f\u54c1\u4e34\u5e8a\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u65b9\u6848\u662f\u4e0d\u80fd\u968f\u610f\u8c03\u6574\u7684\uff0c\u4f46\u662f\u4e00\u4e9b\u751f\u7269\u5236\u5242\u7814\u7a76\u6240\u53ef\u80fd\u968f\u65f6\u90fd\u4f1a\u8c03\u6574\u7ec6\u80de\u5236\u5907\u7684\u65b9\u6cd5\uff0c\u540c\u4e00\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5148\u540e\u53c2\u4e0e\u7684\u60a3\u8005\u4f7f\u7528\u7684\u90fd\u4e0d\u662f\u540c\u4e00\u65b9\u6cd5\u5236\u5907\u7684\u7ec6\u80de\u3002<\/span><\/p>\n


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\u56fd\u5bb6\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u9ad8\u5efa\u8d85\u5728\u5176\u6587\u7ae0\u300a\u4e2d\u7f8e\u4e24\u56fdCAR-T\u7ec6\u80de\u4e34\u5e8a\u8bd5\u9a8c\u6bd4\u8f83\u5206\u6790\u300b\u4e2d\u6307\u51fa\uff0c\u4e2d\u56fd\u7684CAR-T\u7ec6\u80de\u4e34\u5e8a\u8bd5\u9a8c\u5177\u6709\u589e\u901f\u5feb\u3001\u6570\u91cf\u5927\u3001\u4e0e\u897f\u65b9\u5148\u8fdb\u6280\u672f\u4ee3\u5dee\u5c0f\u7b49\u7279\u70b9\uff0c\u540c\u65f6\u5b58\u5728\u8bd5\u9a8c\u4eba\u7fa4\u89c4\u6a21\u5c0f\u3001\u8bd5\u9a8c\u8bbe\u8ba1\u8f83\u4e3a\u6fc0\u8fdb\u3001\u5b89\u5168\u6027\u98ce\u9669\u66b4\u9732\u4e0d\u8db3\u7b49\u95ee\u9898\u3002<\/span><\/p>\n


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\u5f90\u5dde\u5e02\u536b\u8ba1\u59d4\u4e00\u4f4d\u5de5\u4f5c\u4eba\u5458\u544a\u8bc9\u300a\u8d22\u7ecf\u300b\u8bb0\u8005\uff0c\u4e8c\u9662\u662f\u7701\u5c5e\u533b\u9662\uff0c\u6240\u5f00\u5c55\u7684\u65b0\u9879\u76ee\u4e5f\u7531\u7701\u4e00\u7ea7\u5ba1\u6279\uff0c\u800c\u5e02\u5c5e\u533b\u9662\u7684\u514d\u75ab\u7ec6\u80de\u7814\u7a76\u9879\u76ee\u65e9\u5df2\u5168\u90e8\u53eb\u505c\u3002\u5f90\u5dde\u5e02\u836f\u76d1\u5c40\u4e5f\u8868\u793a\uff0c\u4ed6\u4eec\u53ea\u8d1f\u8d23\u5df2\u7ecf\u4e0a\u5e02\u7684\u836f\u54c1\u8d28\u91cf\u76d1\u7ba1\uff0c\u4ece\u672a\u6536\u5230\u4e0a\u7ea7\u4efb\u4f55\u5173\u4e8eCAR-T\u7ba1\u7406\u7684\u901a\u77e5\u3002<\/span><\/strong><\/p>\n


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\u5728\u6c5f\u82cf\u7701\u836f\u76d1\u5c40\u5bf9\u4e8c\u9662\u7684\u56de\u590d\u4e2d\u8868\u660e\uff0c\u5982\u679c\u5df2\u7ecf\u901a\u8fc7\u56fd\u5bb6\u836f\u76d1\u5c40\u5ba1\u6279\uff0c\u83b7\u5f97\u836f\u54c1\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\uff0c\u90a3\u4e48\u5176\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5177\u4f53\u5f00\u5c55\u9700\u8981\u7ecf\u8fc7\u7701\u836f\u76d1\u5c40\u5ba1\u6838\u3002\u5982\u679c\u5e76\u6ca1\u6709\u5411\u56fd\u5bb6\u836f\u76d1\u5c40\u62a5\u8bf7\uff0c\u4e5f\u5c31\u4e0d\u5728\u7701\u836f\u76d1\u5c40\u7ba1\u8f96\u8303\u56f4\uff0c\u53ea\u9700\u8981\u901a\u8fc7\u533b\u9662\u5185\u90e8\u7684\u5ba1\u6838\u3002<\/span><\/p>\n


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\u4e2d\u56fd\u5927\u90e8\u5206\u7684CAR-T\u4e34\u5e8a\u8bd5\u9a8c\u90fd\u5c5e\u4e8e\u6b64\u7c7b\u6d41\u7a0b\u3002<\/span><\/p>\n


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\u300a\u8d22\u7ecf\u300b\u8bb0\u8005\u5c31CAR-T\u4e34\u5e8a\u8bd5\u9a8c\u662f\u5426\u5c5e\u4e8e\u836f\u54c1\u4e34\u5e8a\u8bd5\u9a8c\u5411\u56fd\u5bb6\u836f\u76d1\u5c40\u6c42\u8bc1\uff0c\u622a\u81f3\u53d1\u7a3f\u65f6\u5c1a\u672a\u5f97\u5230\u56de\u590d\u3002<\/span><\/strong><\/p>\n


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2016\u5e74\uff0c\u7f8e\u56fd5\u540d\u60a3\u6709\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u5728\u63a5\u53d7Juno\u516c\u53f8\u7684CAR-T\u4e34\u5e8a\u8bd5\u9a8c\u540e\uff0c\u76f8\u7ee7\u6b7b\u4ea1\u3002Juno\u5f53\u65f6\u4e0d\u5f97\u4e0d\u4e2d\u6b62\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n


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\u4e07\u6653\u6625\u8ba4\u4e3a\uff0c\u6bd2\u526f\u4f5c\u7528\u4e00\u5b9a\u662f\u6709\u7684\uff0c\u5176\u75c7\u72b6\u548c\u76f8\u5e94\u7684\u6cbb\u7597\u65b9\u6848\u4e5f\u6bd4\u8f83\u660e\u786e\uff0c\u57fa\u672c\u53ef\u4ee5\u5f97\u5230\u6709\u6548\u63a7\u5236\uff0c\u6211\u4eec\u786e\u5b9e\u8fd8\u6ca1\u6709\u51fa\u73b0\u81f4\u6b7b\u7684\u60c5\u51b5\u3002<\/span><\/p>\n


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\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

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