{"id":53551,"date":"2018-09-27T01:00:00","date_gmt":"2018-09-30T01:46:16","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/car-t%e7%bb%86%e8%83%9e%e5%85%8d%e7%96%ab%e7%96%97%e6%b3%95%ef%bc%9a%e8%ae%a9%e7%99%8c%e7%97%87%e6%b2%bb%e6%84%88%e6%88%90%e4%b8%ba%e5%8f%af%e8%83%bd%ef%bc%81\/"},"modified":"2018-09-30T09:46:24","modified_gmt":"2018-09-30T01:46:24","slug":"car-t%e7%bb%86%e8%83%9e%e5%85%8d%e7%96%ab%e7%96%97%e6%b3%95%ef%bc%9a%e8%ae%a9%e7%99%8c%e7%97%87%e6%b2%bb%e6%84%88%e6%88%90%e4%b8%ba%e5%8f%af%e8%83%bd%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/53551\/","title":{"rendered":"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01"},"content":{"rendered":"
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CAR-T\uff0c\u5168\u79f0\u662fChimeric Antigen Receptor T-Cell Immunotherapy\u6307\u7684\u662f\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u3002<\/span><\/p>\n

    
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\u662f\u4e0d\u662f\u770b\u8d77\u6765\u5f88\u9ad8\u7ea7\uff0c\u542c\u8d77\u6765\u5374\u5f88\u6655\uff1f<\/span><\/p>\n


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\u90a3\u5c31\u5bf9\u4e86\uff0c\u8fd9\u79cd\u9ed1\u79d1\u6280\u5b9e\u9645\u4e0a\u5c31\u662f\u5c06\u4eba\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u4e00\u79cd\u767d\u7ec6\u80de\u8fdb\u884c\u6539\u9020\uff0c\u4ee5\u6b64\u6765\u6cbb\u6108\u75be\u75c5\u3002<\/span><\/p>\n


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\u8bf4\u8d77CAR-T\u7597\u6cd5\uff0c\u5b83\u6709\u591a\u5e74\u7684\u7814\u7a76\u5386\u53f2\uff0c\u53ea\u662f\u6700\u8fd1\u51e0\u5e74\u624d\u88ab\u6539\u826f\u4f7f\u7528\u5230\u4e34\u5e8a\u4e0a\u7684\u65b0\u578b\u7ec6\u80de\u7597\u6cd5\uff0c\u5728\u6025\u6027\u767d\u8840\u75c5\u548c\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u821e\u53f0\u4e0a\uff0cCAR-T\u514d\u75ab\u7597\u6cd5\u53ef\u4ee5\u8bf4\u662f\u95ea\u4eae\u767b\u573a\uff0c\u5982\u4e00\u9897\u9897\u95ea\u95ea\u4eae\u8d77\u7684\u660e\u661f\uff0c\u5b83\u6709\u7740\u663e\u8457\u7684\u7597\u6548\uff0c\u88ab\u8ba4\u4e3a\u662f\u6700\u6709\u524d\u666f\u7684\u80bf\u7624\u6cbb\u7597\u65b9\u5f0f\u4e4b\u4e00\u3002<\/strong><\/span><\/p>\n


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\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/p>\n


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CAR-T\u514d\u75ab\u7597\u6cd5\u548c\u5176\u4ed6\u514d\u75ab\u7597\u6cd5\u7c7b\u4f3c\uff0c\u5b83\u7684\u539f\u7406\u5c31\u662f\u5229\u7528\u75c5\u4eba\u81ea\u8eab\u7684\u514d\u75ab\u7ec6\u80de\u6765\u6e05\u9664\u764c\u7ec6\u80de\uff0c\u552f\u4e00\u6709\u6240\u4e0d\u540c\u7684\u662f\uff0c\u5b83\u662f\u4e00\u79cd\u7ec6\u80de\u7597\u6cd5\uff0c\u800c\u4e0d\u662f\u4e00\u79cd\u836f\u3002<\/strong><\/span><\/p>\n

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\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/section>\n<\/section>\n
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CAR-T\u8fdb\u884c\u6cbb\u7597\uff0c\u5927\u81f4\u901a\u8fc7\u4ee5\u4e0b\u6b65\u9aa4\u8fdb\u884c\uff1a<\/span><\/strong>\u4ece\u60a3\u8005\u4f53\u5185\u63d0\u53d6t\u7ec6\u80de\uff1b<\/span>\u5229\u7528\u57fa\u56e0\u5de5\u7a0b\u6280\u672f\u5c06\u5176\u6539\u9020\u4e3aCAR-T\u7ec6\u80de\uff1b\u5927\u91cf\u6269\u589eCAR-T\u7ec6\u80de\uff1b\u5c06\u5176\u8f93\u56de\u81f3\u60a3\u8005\u4f53\u5185\u5c55\u5f00\u6cbb\u7597\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5<\/span><\/strong><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n


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\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/p>\n

CAR-T \u53d1\u5c55\u7b80\u53f2<\/span><\/p>\n


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\u201cCAR-T\u7597\u6cd5\u201d\u5230\u5e95\u662f\u4ec0\u4e48\uff1f<\/span><\/p>\n

\u9996\u5148\uff0c\u7fd4\u53d4\u5148\u7ed9\u5927\u5bb6\u79d1\u666e\u4e00\u4e0b\uff1a<\/span><\/p>\n


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CAR-T\u7597\u6cd5\uff0c\u5373\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff0c\u662f\u4e00\u79cd\u65b0\u578b\u7684\u7ec6\u80de\u7597\u6cd5\u3002\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6280\u672f\uff0c\u4eba\u5de5\u6539\u9020\u80bf\u7624\u60a3\u8005\u7684T\u7ec6\u80de\uff0c\u5728\u4f53\u5916\u5927\u91cf\u57f9\u517b\u540e\u751f\u6210\u80bf\u7624\u7279\u5f02\u6027CAR-T\u7ec6\u80de\uff0c\u518d\u5c06\u5176\u56de\u8f93\u5165\u60a3\u8005\u4f53\u5185\u7528\u4ee5\u653b\u51fb\u764c\u7ec6\u80de\u3002<\/span><\/p>\n

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\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/span><\/p>\n


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CAR-T\u582a\u79f0\u201c\u5b9a\u5411\u5de1\u822a\u751f\u7269\u5bfc\u5f39\u201d\uff0c\u7f8e\u56fd\u653f\u5e9c\u5df2\u7ecf\u6279\u51c6CAR-T\u7ec6\u80de\u836f\u7269\u7597\u6cd5\u4e0a\u5e02\uff0c\u8fd9\u8ba9\u6cbb\u7597\u764c\u75c7\u548c\u5176\u4ed6\u4e25\u91cd\u5371\u53ca\u751f\u547d\u7684\u75be\u75c5\u6709\u4e86\u65b0\u7684\u9009\u62e9\u3002\u4f46\u8fc4\u4eca\u4e3a\u6b62\uff0cCAR-T\u7ec6\u80de\u7597\u6cd5\u4ec5\u88ab\u6279\u51c6\u5728\u59cb\u4e8eB\u7ec6\u80de\u7684\u67d0\u4e9b\u767d\u8840\u75c5\u548c\u6dcb\u5df4\u7624\u4e0a\u4f7f\u7528\u3002\u7814\u7a76\u4eba\u5458\u6b63\u81f4\u529b\u4e8e\u5168\u65b9\u4f4d\u6539\u9020T\u7ec6\u80de\uff0c\u8fdb\u4e00\u6b65\u964d\u4f4e\u6cbb\u7597\u98ce\u9669\u3002<\/span><\/p>\n

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\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/section>\n<\/section>\n
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\u5728\u8fc7\u53bb\u7684\u4e00\u5e74\u4e2d\uff0c\u7f8e\u56fdFDA\u8fde\u7eed\u6279\u51c6\u4e86\u4e09\u6b3eCAR-T\u7597\u6cd5\u4e0a\u5e02\uff0c\u53ef\u4ee5\u8bf4\u662f\u6709\u7740\u8de8\u65f6\u4ee3\u7684\u610f\u4e49\u3002<\/span><\/strong><\/p>\n


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\u8fd9\u4e09\u6b3eCAR-T\u7597\u6cd5\u5206\u522b\u662f\uff1a8\u6708\u5e95\u8bfa\u534enovartis\u7684kymrish,10\u6708\u51ef\u7279kite\u7684yescarta\u548c12\u6708\u65af\u5df4\u514b\u533b\u7597spark therapeutics\u7684luxturna\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/p>\n


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\u5982\u679c\u8bf4\u4e4b\u524d\u7684\u836f\u7269\u662f\u6ca1\u6709\u751f\u547d\u7684\uff0c\u90a3\u4e48\u8fd9\u4e09\u6b3e\u7597\u6cd5\u5219\u662f\u9971\u542b\u7740\u751f\u547d\u7684\u80fd\u91cf\u3002<\/span><\/strong>\u4e16\u754c\u4e0a\u7b2c\u4e00\u4f4d\u63a5\u53d7CAR-T\u7597\u6cd5\u7684\u5c0f\u5973\u5b69\u513f\u827e\u7c73\u8389\u00b7\u6000\u7279\u6d77\u5fb7\uff08Emily Whitehead\uff09\u5c31\u5f88\u597d\u7684\u8be0\u91ca\u4e86\u8fd9\u4e00\u70b9\u3002<\/span><\/p>\n

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\u751f\u547d\u7684\u5947\u8ff9\uff1a\u5168\u7403\u7b2c\u4e00\u4e2a\u63a5\u53d7CAR-T\u6cbb\u7597<\/span><\/strong><\/p>\n

\u7684\u767d\u8840\u75c5\u5973\u5b69\u5982\u4eca\u5df2\u88ab\u6210\u529f\u6cbb\u6108<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u89c1\u60ef\u4e86\u751f\u6b7b\uff0c\u4eba\u4e5f\u4f1a\u53d8\u5f97\u9ebb\u6728\uff0c\u5927\u6982\u4eba\u4eec\u5bf9\u4e8e\u533b\u751f\u603b\u4f1a\u4ea7\u751f\u8fd9\u6837\u7684\u8bef\u89e3\u3002\u4f46\u5728\u9769\u547d\u6027\u7684\u7597\u6cd5\u51fa\u73b0\u7684\u65f6\u5019\uff0c\u6ca1\u6709\u4eba\u4f1a\u6bd4\u4ed6\u4eec\u66f4\u6fc0\u52a8\u3002<\/span><\/p>\n


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\u827e\u7c73\u8389\u00b7\u6000\u7279\u6d77\u5fb7\uff08Emily Whitehead\uff09\u53ef\u80fd\u662f\u5168\u4e16\u754c\u4e0a\u6700\u6709\u540d\u7684\u60a3\u8005\uff0c\u8fde\u5965\u5df4\u9a6c\u90fd\u4e13\u95e8\u63a5\u89c1\u8fc7\u5979\u3002\u8fd9\u4e00\u5207\uff0c\u90fd\u56e0\u4e3a\u5979\u662f\u7b2c\u4e00\u4f4d\u63a5\u53d7\u4e86\u201cCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u201d\u7684\u513f\u7ae5\uff0c\u5e76\u4e14\u6210\u529f\u5730\u201c\u6cbb\u6108\u201d\u4e86\u81ea\u8eab\u7684\u767d\u8840\u75c5\u3002<\/strong><\/span><\/p>\n<\/blockquote>\n


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\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/p>\n


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\u827e\u7c73\u8389\u00b7\u6000\u7279\u6d77\u5fb7\u5728\u4e94\u5c81\u65f6\u88ab\u8bca\u65ad\u60a3\u4e0a\u6025\u6027\u6dcb\u5df4\u767d\u8840\u75c5\uff08\u7b80\u79f0\uff1aALL\uff09\uff0c\u5979\u8eab\u4f53\u91cc\u4e00\u79cd\u672c\u6765\u5e2e\u52a9\u8eab\u4f53\u62b5\u5fa1\u5916\u754c\u611f\u67d3\u7684\u514d\u75abB\u7ec6\u80de\u53d1\u751f\u4e86\u764c\u53d8\uff0c\u5728\u5979\u4f53\u5185\u91ce\u8349\u4e00\u822c\u6269\u6563\u5f00\u6765\uff0c\u66f4\u4e0d\u5e78\u7684\u662f\uff0c\u827e\u7c73\u8389\u7684\u767d\u8840\u75c5\u5bf9\u73b0\u6709\u7684\u5316\u7597\u836f\u7269\u5e76\u4e0d\u654f\u611f\u3002<\/span><\/p>\n


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\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/p>\n


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\u5728\u6025\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\u4e24\u6b21\u590d\u53d1\u540e\u547d\u60ac\u4e00\u7ebf\u4e4b\u9645\uff0c\u827e\u7c73\u8389\u63a5\u53d7\u4e86\u4e00\u79cd\u5b9e\u9a8c\u6027\u7684\u767d\u8840\u75c5\u65b0\u7597\u6cd5\u2014\u2014\u514d\u75ab\u7ec6\u80de\u7597\u6cd5<\/strong>\uff1a\u533b\u751f\u4ece\u5979\u4f53\u5185\u5206\u79bb\u5177\u6709\u764c\u75c7\u6740\u4f24\u6f5c\u529b\u7684T\u7ec6\u80de\uff0c\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u8ba9\u5176\u5e26\u4e0a\u4e00\u79cd\u764c\u75c7\u6297\u539f\u7279\u5f02\u6027\u7684\u5d4c\u5408\u6027\u53d7\u4f53\uff0c\u4f7f\u5b83\u4eec\u53ef\u4ee5\u53d1\u73b0\u548c\u653b\u51fb\u764c\u7ec6\u80de\uff0c\u5c06\u8fd9\u4e9b\u7ec6\u80de\u5728\u4f53\u5916\u6269\u589e\u540e\u518d\u8f93\u5165\u5230\u5c0f\u827e\u7c73\u8389\u4f53\u5185\u3002<\/span><\/p>\n


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\u88ab\u6539\u9020\u7684T\u7ec6\u80de\u8fdb\u5165\u4f53\u5185\u540e\uff0c\u5728\u8fc5\u901f\u6740\u6b7b\u5927\u91cf\u764c\u7ec6\u80de\u7684\u540c\u65f6\uff0c\u4e5f\u4f1a\u77ac\u95f4\u5728\u5c40\u90e8\u4ea7\u751f\u8d85\u5927\u91cf\u7684\u7ec6\u80de\u56e0\u5b50\uff0c\u5f15\u8d77\u60ca\u4eba\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u5373\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\uff0c\u53c8\u79f0\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u3002<\/strong>\u8fd9\u4f7f\u5f97\u827e\u7c73\u8389\u5728\u6cbb\u7597\u7684\u6700\u521d\u9636\u6bb5\u51fa\u73b0\u4e86\u53ef\u6015\u7684\u526f\u4f5c\u7528\uff0c\u7ec6\u80de\u5728\u6ce8\u5c04\u5230\u4f53\u5185\u540e\uff0c\u827e\u7c73\u8389\u8fc5\u901f\u53d1\u70e7\uff0c\u8840\u538b\u9aa4\u964d\uff0c\u91cd\u5ea6\u660f\u8ff7\uff0c\u5728\u91cd\u75c7\u76d1\u62a4\u5ba4\u91cc\u9760\u547c\u5438\u673a\u71ac\u8fc7\u4e86\u4e24\u5468\u3002<\/span><\/p>\n


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\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/p>\n


<\/p>\n

\u5c31\u5728\u6240\u6709\u4eba\u8ba4\u4e3a\u827e\u7c73\u8389\u633a\u4e0d\u8fc7\u6765\u7684\u65f6\u5019\uff0c\u5947\u8ff9\u53d1\u751f\u4e86\uff0c\u5728\u7ed9\u836f\u540e\u7684\u51e0\u4e2a\u5c0f\u65f6\u4e4b\u5185\uff0c\u5979\u7684\u8eab\u4f53\u72b6\u51b5\u8fc5\u901f\u6062\u590d\uff0c\u5e76\u5728\u7b2c\u4e8c\u5929\u9192\u4e86\u8fc7\u6765\u3002\u800c\u5979\u4f53\u5185\u539f\u672c\u8086\u8650\u7684\u764c\u7ec6\u80de\u4e5f\u88ab\u6e05\u9664\u6b86\u5c3d\uff0c\u5979\u4f53\u5185\u7684\u764c\u7ec6\u80de\u5b8c\u5168\u6d88\u5931\u4e86\u3002\u66f4\u4ee4\u4eba\u60ca\u559c\u7684\u662f\uff0c\u827e\u7c73\u8389\u5728\u63a5\u53d7\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de(CAR-T)\u7597\u6cd5\u6cbb\u7597\u76845\u5e74\u540e\u4ecd\u7136\u6ca1\u6709\u590d\u53d1\u3002<\/strong><\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/p>\n<\/section>\n

\n
\n
\n

\u25b2\u827e\u7c73\u8389\u572810\u5c81\u65f6\u5728\u767d\u5bab\u88ab\u5965\u5df4\u9a6c\u63a5\u89c1\u30022012\u5e74\uff0c\u5979\u662f\u5168\u7403\u7b2c\u4e00\u4e2a\u63a5\u53d7\u5b9e\u9a8c\u6027\u7ec6\u80de\u7597\u6cd5\u7684\u513f\u7ae5<\/span><\/p>\n


<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

\u5982\u4eca\uff0c\u8fd9\u4f4d\u5168\u7403\u7b2c\u4e00\u4e2a\u63a5\u53d7CAR-T\u7ec6\u80de\u6cbb\u7597\u7684\u767d\u8840\u75c5\u5973\u5b69\uff0c\u5df2\u7ecf\u5065\u5eb7\u5feb\u4e50\u7684\u8fce\u6765\u4e8612\u5c81\u7684\u751f\u65e5\u3002
<\/span><\/p>\n


<\/p>\n

\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/p>\n

\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/p>\n<\/section>\n

\n
\n
\n


<\/p>\n

<\/span><\/p>\n

\u7f8e\u56fd\u65f6\u95f42017\u5e747\u670812\u65e5\uff0cFDA\u80bf\u7624\u836f\u7269\u4e13\u5bb6\u54a8\u8be2\u59d4\u5458\u4f1a\uff08ODAC\uff09\u4ee510-0\u7684\u6295\u7968\u7ed3\u679c\uff0c\u652f\u6301\u6279\u51c6\u4f7f\u7528\u7ecf\u57fa\u56e0\u6539\u9020\u7684\u60a3\u8005\u81ea\u8eab\u514d\u75ab\u7ec6\u80de\u6765\u6cbb\u7597\u8840\u6db2\u764c\u75c7\u3002\u8fd9\u9879\u6280\u672f\u7528\u4e8e\u6cbb\u7597\u60a3\u6709\u665a\u671f\u767d\u8840\u75c5\u7684\u513f\u7ae5\u548c\u5e74\u8f7b\u6210\u4eba\u60a3\u8005\u3002\u8fd9\u610f\u5473\u7740\uff0cCAR-T\u7ec6\u80de\u7597\u6cd5\u5c06\u4f1a\u4f5c\u4e3a\u836f\u7269\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u827e\u7c73\u8389\u4e00\u5bb6\u4eba\uff0c\u4ee5\u53ca\u63a5\u53d7CAR-T\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u540e\u83b7\u5f97\u91cd\u751f\u7684\u60a3\u8005\u57287\u670812\u65e5\u8fd9\u5929\u4e5f\u90fd\u51fa\u73b0\u5728\u4e86FDA\u7684\u8bc4\u5ba1\u73b0\u573a\uff0c\u73b0\u8eab\u8bf4\u6cd5\u547c\u5401\u59d4\u5458\u4f1a\u6279\u51c6\u8fd9\u79cd\u633d\u6551\u4e86\u4ed6\u4eec\u751f\u547d\u7684\u6cbb\u7597\u624b\u6bb5\u3002\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5dde\u79d1\u5b66\u5bb6\u3001CAR-T\u7597\u6cd5\u7684\u5148\u9a71Carl June\u6559\u6388\u8bf4\uff0c\u8fd9\u5c06\u6253\u5f00\u514d\u75ab\u7597\u6cd5\u7684\u6700\u65b0\u7bc7\u7ae0\u2014\u2014\u201c\u771f\u6b63\u7684\u6d3b\u6027\u836f\u7269\u201d\u3002<\/strong><\/span><\/p>\n


<\/strong><\/span><\/p>\n

\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

12\u5c81\u7684\u827e\u7c73\u8389\u00b7\u6000\u7279\u6d77\u5fb7\u548c\u5979\u7684\u7236\u6bcd\u51fa\u73b0\u5728FDA\u4f1a\u8bae\u4e0a<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n

<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u53c2\u4e0e\u8fd9\u9879\u6cbb\u7597\u7684\u533b\u751f\u8868\u793a\uff0cCAR-T\u6280\u672f\u5728\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u662f\u6709\u6548\u679c\u7684\uff0c\u4ed6\u4eec\u7684\u56e2\u961f\u5728\u524d\u671f\u89c2\u6d4b\u5230\uff0c\u7ecf\u8fc7\u6539\u9020\u7684T\u7ec6\u80de\u8f93\u5165\u5230\u60a3\u8005\u4f53\u5185\u540e\uff0c\u6709\u4f5c\u7528\u7684\u60a3\u8005\u6bd4\u4f8b\u8fbe\u523093%\uff0c<\/strong>\u4e00\u5e74\u53ca\u4ee5\u540e\uff0c\u4f53\u5185\u7684\u8fd9\u4e9b\u6539\u9020T\u7ec6\u80de\u4ecd\u7136\u53d1\u6325\u4f5c\u7528\u7684\u60a3\u8005\u6bd4\u4f8b\u8fbe\u5230\u4e8678%\u7684\u9ad8\u6cbb\u6108\u7387\u3002<\/strong><\/span><\/p>\n

 <\/p>\n

\u4e0d\u53ea\u662f\u827e\u7c73\u8389\uff0c\u5728CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u524d\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u6765\u81ea\u5341\u51e0\u4e2a\u56fd\u5bb6\u7684\u60a3\u6709\u767d\u8840\u75c5\u513f\u7ae5\u548c\u9752\u5c11\u5e74\uff0c\u4ed6\u4eec\u5728\u73b0\u6709\u7597\u6cd5\u6cbb\u7597\u4e0b\u901a\u5e38\u9884\u540e\u5f88\u5dee\u3002\u5728\u63a5\u53d7\u8fd9\u4e00\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u540e\uff0c\u670983\uff05\u7684\u60a3\u8005\u5f97\u5230\u4e86\u7f13\u89e3\u3002\u6cbb\u7597\u7ed3\u675f\u4e00\u5e74\u540e\uff0c\u4e09\u5206\u4e4b\u4e8c\u7684\u60a3\u8005\u4ecd\u7136\u4fdd\u6301\u75be\u75c5\u7f13\u89e3\u72b6\u6001\u3002\u827e\u7c73\u8389\u7684\u6545\u4e8b\u5728\u66f4\u591a\u7684\u60a3\u6709\u8840\u6db2\u80bf\u7624\u7684\u75c5\u4eba\u8eab\u4e0a\u5f97\u5230\u5ef6\u7eed\u3002<\/strong><\/span><\/p>\n

\n
\n


<\/p>\n

\n
\n
\n
\n

3<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n

CAR-T\u7ec6\u80de\u7597\u6cd5<\/strong><\/h3>\n

\u6700\u65b0\u7684\u6280\u672f\u7a81\u7834\u4e0e<\/strong>\u5728\u4e2d\u56fd\u7684\u53d1\u5c55<\/strong><\/h3>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n<\/section>\n<\/section>\n

<\/span><\/p>\n

\u5f53\u7136\uff0cCAR-T\u672c\u8eab\u8fd8\u6709\u5f88\u591a\u672a\u77e5\u4e9f\u5f85\u63a2\u7d22\uff0c\u79d1\u5b66\u5bb6\u4eec\u4ecd\u5728\u4e0d\u65ad\u5730\u901a\u8fc7\u5404\u79cd\u52aa\u529b\u6765\u5b8c\u5584\u548c\u6539\u8fdbCAR-T\u6cbb\u7597\u6280\u672f\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u53ef\u4ee5\u7cbe\u51c6\u201c\u542f\u505c\u201d\u7684\u9776\u7ec6\u80de<\/span><\/strong><\/p>\n

 <\/span><\/p>\n

\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/p>\n

<\/span>
<\/p>\n

\u501f\u52a9\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CARs\uff09\u6216T\u7ec6\u80de\u53d7\u4f53\uff08TCRs\uff09\uff0cT\u7ec6\u80de\u80fd\u591f\u5b9a\u5411\u6740\u6b7b\u764c\u7ec6\u80de\u3002\u7136\u800c\uff0c\u56e0\u80bf\u7624\u8868\u8fbe\u7279\u5f02\u6027\u5355\u4e00\u6297\u539f\u7684\u60c5\u51b5\u8f83\u4e3a\u7f55\u89c1\uff0c\u4f7f\u5f97\u8fd9\u4e00\u7597\u6cd5\u7684\u53d1\u5c55\u53d7\u5230\u4e86\u4e00\u5b9a\u7684\u5236\u7ea6\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u79d1\u5b66\u5bb6Leonardo Morsut\u548cKole T. Roybal\u7b49\u4eba\u6b63\u5728\u7814\u53d1\u4e00\u79cd\u7cfb\u7edf\uff0c\u4ee5\u63a7\u5236\u4eba\u4f53\u5de5\u7a0bT\u7ec6\u80de\u4f55\u65f6\u4f55\u5730\u88ab\u6fc0\u6d3b\u3002\u4ed6\u4eec\u628a\u4e00\u79cd\u86cb\u767d\u8d28\u9644\u7740\u5728T\u7ec6\u80de\u8868\u9762\uff0c\u8fd9\u79cd\u53cc\u53d7\u4f53AND-gate T\u7ec6\u80de\uff08dual-receptor AND-gate T cells\uff09\u53ea\u6709\u5728\u80bf\u7624\u7ec6\u80de\u540c\u65f6\u8868\u8fbe\u4e24\u79cd\u6297\u539f\u7684\u60c5\u51b5\u4e0b\u624d\u4f1a\u88ab\u6fc0\u6d3b\u3002\u4f53\u5185\u5b9e\u9a8c\u4e2d\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u5c55\u73b0\u51fa\u4e86\u7cbe\u51c6\u7684\u8bc6\u522b\u4e0e\u6cbb\u7597\u80fd\u529b\uff0c\u80fd\u591f\u533a\u5206\u51fa\u53ea\u62e5\u6709\u5355\u4e2a\u6297\u539f\u7684\u975e\u76ee\u6807\u80bf\u7624\uff0c\u4e14\u6709\u6548\u6e05\u9664\u643a\u5e26\u7ec4\u5408\u6297\u539f\u7684\u80bf\u7624\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u66f4\u5b89\u5168\u7684\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u4ec5\u4f5c\u7528\u4e8e\u60a3\u8005\u7684T\u7ec6\u80de<\/span><\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/p>\n

<\/span>
<\/p>\n

IL-2\u662f\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u4e00\u7c7b\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff0c\u80fd\u8c03\u63a7\u514d\u75ab\u7cfb\u7edf\u4e2d\u767d\u8840\u7403\u7684\u7ec6\u80de\u6d3b\u6027\uff0c\u5e76\u53c2\u4e0e\u6297\u4f53\u53cd\u5e94\u3001\u9020\u8840\u548c\u80bf\u7624\u76d1\u89c6\u3002<\/strong>IL-2\u4e3b\u8981\u7531T\u7ec6\u80de\u4ea7\u751f\u3002\u7531\u4e8e\u7528\u4e8e\u6807\u8bb0\u6807\u8bb0\u80bf\u7624\u7ec6\u80de\u7684\u76ee\u6807\u6297\u539f\u5728\u5176\u5b83\u5065\u5eb7\u7ec4\u7ec7\u4e2d\u4e5f\u6709\u53ef\u80fd\u5b58\u5728\uff0c\u8fd9\u5c31\u53ef\u80fd\u5f15\u53d1\u5371\u53ca\u751f\u547d\u7684\u4e0d\u826f\u53cd\u5e94\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4f46\u79d1\u5b66\u5bb6\u4eec\u627e\u5230\u4e86\u4e00\u79cd\u65b9\u6cd5\uff0c\u6539\u53d8\u7ec6\u80de\u56e0\u5b50IL-2\u7684\u6027\u72b6\u4ee5\u53ca\u4e0e\u4e4b\u76f8\u5173\u7684T\u7ec6\u80de\u53d7\u4f53\uff0cIL-2\u5c06\u53ea\u4f5c\u7528\u4e8e\u60a3\u8005\u4f53\u5185\u7684T\u7ec6\u80de\uff0c\u8fd9\u53ef\u5e2e\u52a9T\u7ec6\u80de\u533a\u5206\u5916\u6765\u7ec6\u80de\u4e0e\u81ea\u8eab\u7ec6\u80de\uff0c\u4f7f\u5f97IL-2\u53ea\u4e0e\u88ab\u4fee\u9970\u7684T\u7ec6\u80de\u8fdb\u884c\u4ea4\u6d41\u5e76\u4fc3\u8fdb\u5176\u4ea7\u751f\uff0c\u800c\u4e0d\u662f\u4e0e\u8eab\u4f53\u5176\u4ed6\u90e8\u4f4d\u7684T\u7ec6\u80de\u8fdb\u884c\u4ea4\u6d41\u3002\u8fd9\u5c31\u4f7fCAR-T\u6cbb\u7597\u66f4\u6709\u9488\u5bf9\u6027\uff0c\u66f4\u5177\u5b89\u5168\u6027\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u90a3\u4e48\uff0cCAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u4ef7\u683c\u5982\u4f55\uff1f<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\"CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff1a\u8ba9\u764c\u75c7\u201c\u6cbb\u6108\u201d\u6210\u4e3a\u53ef\u80fd\uff01\"<\/p>\n

<\/span>
<\/p>\n

\u76ee\u524d\uff0c\u8bfa\u534e\u7684CAR-T\u7ec6\u80de\u7597\u6cd5Kymriah\u5728\u7f8e\u56fd\u7684\u5b9a\u4ef7\u4e3a47.5\u4e07\u7f8e\u5143(\u4e00\u7597\u7a0b)\uff0cKite\u7684Yescarta\u5b9a\u4ef7\u4e3a37.3\u4e07\u7f8e\u5143\uff1b\u5982\u679c\u8fd9\u4e24\u79cd\u7597\u6cd5\u8fdb\u5165\u4e2d\u56fd\u5e76\u4e0a\u5e02\uff0c\u9884\u8ba1\u4ef7\u683c\u53ef\u80fd\u9ad8\u8fbe\u767e\u4e07\u4eba\u6c11\u5e01\u3002\u4e0d\u8fc7\uff0c\u5728\u66f4\u52a0\u5f00\u653e\u653f\u7b56\u7684\u652f\u6301\u4e0b\uff0c\u56fd\u5185CAR-T\u4e0a\u5e02\u6b65\u4f10\u4e5f\u5c06\u52a0\u5feb\u3002\u4e13\u5bb6\u8868\u793a\uff1a<\/span><\/p>\n


<\/span><\/p>\n

\n

 CAR-T\u662f\u4e3a\u6570\u4e0d\u591a\u7684\u4e2d\u56fd\u4e0e\u897f\u65b9\u56fd\u5bb6\u6bd4\u80a9\u7684\u836f\u54c1\u7814\u53d1\u9886\u57df\uff0c\u751a\u81f3\u5728\u67d0\u4e9b\u65b9\u5411\u4e0a\u4e2d\u56fd\u8fd8\u5177\u6709\u9886\u5148\u4f18\u52bf\u3002\u53ea\u6709\u4e2d\u56fd\u672c\u571f\u4f01\u4e1a\u5177\u6709\u4e86\u7814\u53d1\u7684\u5b9e\u529b\uff0c\u624d\u6709\u53ef\u80fd\u4e89\u53d6\u5230\u5b9a\u4ef7\u6743\uff0c\u4e0d\u7136\u5c31\u53ea\u80fd\u88ab\u56fd\u5916\u516c\u53f8\u5784\u65ad\u3002<\/strong><\/span><\/p>\n<\/blockquote>\n

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\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

CAR-T\uff0c\u5168\u79f0\u662fChimeric Antigen Receptor T-Cell Immunotherapy […]<\/p>\n","protected":false},"author":1,"featured_media":53552,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/53551"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=53551"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/53551\/revisions"}],"predecessor-version":[{"id":53573,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/53551\/revisions\/53573"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/53552"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=53551"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=53551"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=53551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}