{"id":53714,"date":"2018-09-27T01:00:00","date_gmt":"2018-09-30T01:48:16","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e6%81%a9%e6%9d%82%e9%b2%81%e8%83%ba%e7%94%a8%e4%ba%8e%e9%9d%9e%e8%bd%ac%e7%a7%bb%e6%80%a7%e5%8e%bb%e5%8a%bf%e6%8a%b5%e6%8a%97%e5%89%8d%e5%88%97%e8%85%ba%e7%99%8c%e6%82%a3%e8%80%85%e8%8e%b7chmp\/"},"modified":"2018-09-30T09:48:16","modified_gmt":"2018-09-30T01:48:16","slug":"%e6%81%a9%e6%9d%82%e9%b2%81%e8%83%ba%e7%94%a8%e4%ba%8e%e9%9d%9e%e8%bd%ac%e7%a7%bb%e6%80%a7%e5%8e%bb%e5%8a%bf%e6%8a%b5%e6%8a%97%e5%89%8d%e5%88%97%e8%85%ba%e7%99%8c%e6%82%a3%e8%80%85%e8%8e%b7chmp","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/53714\/","title":{"rendered":"\u6069\u6742\u9c81\u80fa\u7528\u4e8e\u975e\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u524d\u5217\u817a\u764c\u60a3\u8005\u83b7CHMP\u8ba4\u53ef"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section label=\"Copyleft 2018 iPaiban All lefts Reserved \uff08\u672c\u6837\u5f0f\u5df2\u505a\u7248\u6743\u4fdd\u62a4\uff0c\u672a\u7ecf\u6b63\u5f0f\u6388\u6743\u4e0d\u5141\u8bb8\u4efb\u4f55\u7b2c\u4e09\u65b9\u7f16\u8f91\u5668\u3001\u4f01\u4e1a\u3001\u4e2a\u4eba\u4f7f\u7528\uff0c\u8fdd\u8005\u5fc5\u7ea0\uff09\" style=\"width: 98%;border-width: initial;border-color: initial;border-style: none;margin: 0rem auto;\" donone=\"shifuMouseDownPayStyle(&#39;shifu_qmi_006&#39;)\">\n<section style=\"width:1.25rem;height:2px;background-color:rgb(130, 195, 26);border-radius:0.625rem;opacity:0.3;color:rgb(130, 195, 26);\" class=\"ipaiban-bg\"><\/section>\n<section style=\"width:2.5rem;height:2px;background-color:rgb(130, 195, 26);margin-top:3px;border-radius:0.625rem;opacity:0.6;color:rgb(130, 195, 26);\" class=\"ipaiban-bg\"><\/section>\n<section style=\"height:2px;background-color:rgb(130, 195, 26);margin-top:3px;border-radius:0.625rem;color:rgb(130, 195, 26);\" class=\"ipaiban-bg\"><\/section>\n<section style=\"font-size:0.875rem;letter-spacing:1.5px;text-align:center;padding:0.625rem;color:rgb(68, 68, 68);line-height:1.75em;\">\n<p style=\"margin-bottom: 10px;text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><span style=\"color: rgb(85, 87, 89);\">2018<\/span><span style=\"color: rgb(85, 87, 89);font-family: \u5b8b\u4f53;\">\u5e74<\/span><span style=\"color: rgb(85, 87, 89);\">9<\/span><span style=\"color: rgb(85, 87, 89);font-family: \u5b8b\u4f53;\">\u6708<\/span><span style=\"color: rgb(85, 87, 89);\">24<\/span><span style=\"color: rgb(85, 87, 89);font-family: \u5b8b\u4f53;\">\u65e5<\/span><span style=\"color: rgb(85, 87, 89);\">,<\/span><span style=\"color: rgb(85, 87, 89);font-family: \u5b8b\u4f53;\">\u5b89\u65af\u6cf0\u6765\u5236\u836f\u516c\u53f8\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98<\/span><span style=\"color: rgb(85, 87, 89);\">Kenki Yasukawa<\/span><span style=\"color: rgb(85, 87, 89);font-family: \u5b8b\u4f53;\">\u535a\u58eb\u4eca\u5929\u5ba3\u5e03\uff0c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08<\/span><span style=\"color: rgb(85, 87, 89);\">EMA<\/span><span style=\"color: rgb(85, 87, 89);font-family: \u5b8b\u4f53;\">\uff09\u4eba\u7528\u836f\u59d4\u5458\u4f1a\uff08<\/span><span style=\"color: rgb(85, 87, 89);\">CHMP<\/span><span style=\"color: rgb(85, 87, 89);font-family: \u5b8b\u4f53;\">\uff09\u91c7\u53d6\u4e86\u5c06<\/span><span style=\"color: rgb(85, 87, 89);\">Xtandi<\/span><span style=\"color: rgb(85, 87, 89);font-family: \u5b8b\u4f53;\">\uff08\u6069\u6742\u9c81\u80fa\uff09\u7684\u9002\u5e94\u75c7\u6269\u5927\u5230\u5305\u62ec\u5177\u6709\u9ad8\u98ce\u9669\u975e\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff08<\/span><span style=\"color: rgb(85, 87, 89);\">nmCRPC<\/span><span style=\"color: rgb(85, 87, 89);font-family: \u5b8b\u4f53;\">\uff09\u7684\u6210\u5e74\u7537\u6027\u7684\u79ef\u6781\u610f\u89c1\uff0c\u5982\u679c\u8be5\u63d0\u8bae\u5f97\u5230\u6b27\u76df\u59d4\u5458\u4f1a\uff08<\/span><span style=\"color: rgb(85, 87, 89);\">EC<\/span><span style=\"color: rgb(85, 87, 89);font-family: \u5b8b\u4f53;\">\uff09\u7684\u6279\u51c6<\/span><span style=\"color: rgb(85, 87, 89);\">&nbsp;<\/span><span style=\"color: rgb(85, 87, 89);font-family: \u5b8b\u4f53;\">\uff0c<\/span><span style=\"color: rgb(85, 87, 89);\">enzalutamide<\/span><span style=\"color: rgb(85, 87, 89);font-family: \u5b8b\u4f53;\">\u5c06\u662f\u7528\u4e8e\u8fd9\u4e00\u75be\u75c5\u5173\u952e\u9636\u6bb5\u7684\u9996\u6279\u6cbb\u7597\u65b9\u6cd5\u4e4b\u4e00\uff0c\u540c\u65f6\u4e5f\u6269\u5927\u4e86\u8be5\u836f\u7684\u7528\u836f\u7fa4\u4f53\u3002<\/span><\/span><span style=\"color:rgb(85,87,89);font-size:16px;\">&nbsp;<\/span><\/p>\n<\/section>\n<section style=\"height:2px;background-color:rgb(130, 195, 26);border-radius:0.625rem;color:rgb(130, 195, 26);\" class=\"ipaiban-bg\"><\/section>\n<section style=\"height:2px;text-align:right;margin-top:3px;\">\n<section style=\"width:2.5rem;height:2px;background-color:rgb(130, 195, 26);border-radius:0.625rem;opacity:0.6;display:inline-block;vertical-align:top;color:rgb(130, 195, 26);\" class=\"ipaiban-bg\"><\/section>\n<\/section>\n<section style=\"height:2px;text-align:right;margin-top:3px;\">\n<section style=\"width:1.25rem;height:2px;background-color:rgb(130, 195, 26);border-radius:0.625rem;opacity:0.3;display:inline-block;vertical-align:top;color:rgb(130, 195, 26);\" class=\"ipaiban-bg\"><\/section>\n<\/section>\n<\/section>\n<section label=\"Copyleft 2018 iPaiban All lefts Reserved \uff08\u672c\u6837\u5f0f\u5df2\u505a\u7248\u6743\u4fdd\u62a4\uff0c\u672a\u7ecf\u6b63\u5f0f\u6388\u6743\u4e0d\u5141\u8bb8\u4efb\u4f55\u7b2c\u4e09\u65b9\u7f16\u8f91\u5668\u3001\u4f01\u4e1a\u3001\u4e2a\u4eba\u4f7f\u7528\uff0c\u8fdd\u8005\u5fc5\u7ea0\uff09\" style=\"width: 98%;border-width: initial;border-color: initial;border-style: none;margin: 0rem auto;\" donone=\"shifuMouseDownPayStyle(&#39;shifu_qmi_014&#39;)\">\n<section style=\"margin: 10px auto;width: 100%;height: 40px;border-bottom: 1px solid rgb(246, 246, 246);overflow: hidden;color: inherit;background-color: rgb(251, 251, 251);text-align: center;\">\n<section style=\"display: inline-block;width: auto;height:2.5rem;margin-left: 20px;border-radius: 10px 0px 10px;transform: skew(-30deg);color: rgb(255, 255, 255);background-color: #03A9F4;\" class=\"ipaiban-bg\">\n<section style=\"padding-right: 30px;padding-left: 30px;font-size: 1rem;line-height: 2.5rem;color: inherit;transform: skew(30deg);\">\n<p><span style=\"color: rgb(255, 0, 0);font-size: 16px;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;font-family: \u5b8b\u4f53;\">\u65b0\u578b\u6cbb\u7597<\/span><span style=\"color: rgb(255, 0, 0);font-size: 16px;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;\">CRPC <\/span><span style=\"color: rgb(255, 0, 0);font-size: 16px;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;font-family: \u5b8b\u4f53;\">\u836f\u7269\u7684\u7814\u53d1\u80cc\u666f<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u524d\u5217\u817a\u764c\u662f\u5168\u7403\u6700\u5e38\u89c1\u764c\u75c7\u4e4b\u4e00\uff0c\u662f\u9020\u6210\u5168\u7403\u7537\u6027\u6b7b\u4ea1\u7684\u7b2c\u4e8c\u5927\u764c\u75c7\u6740\u624b\uff0c2017\u5e74\u7f8e\u56fd\u6709\u8d85\u8fc716\u4e07\u4eba\u88ab\u8bca\u65ad\u51fa\u60a3\u6709\u524d\u5217\u817a\u764c\uff0c\u5c45\u7f8e\u56fd\u7537\u6027\u764c\u75c7\u7b2c\u4e8c\u4f4d\uff0c\u65e9\u671f\u4e34\u5e8a\u7814\u7a76\u8bc1\u5b9eCRPC\u5bf9\u6709\u4e1d\u5206\u88c2\u6291\u5236\u5242\u5c24\u4e3a\u654f\u611f\uff0c\u5982\u591a\u897f\u4ed6\u8d5b\uff08docetaxel\uff0cDTX\uff09\u3002\u56e0\u6b64\u4ee5\u7d2b\u6749\u7c7b\u836f\u7269\u4e3a\u57fa\u7840\u7684\u5316\u7597\u662fCRPC\u76ee\u524d\u6700\u5e38\u7528\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u540e\u6765\u7684\u7814\u7a76\u53d1\u73b0\u4ee5\u7d2b\u886b\u7c7b\u836f\u7269\u4e3a\u57fa\u7840\u7684\u5316\u7597\u4ec5\u53ef\u4f7f\u751f\u5b58\u83b7\u76ca\uff0c\u4f46\u662f\u5f88\u96be\u5b8c\u5168\u63a7\u5236\uff0c\u6240\u4ee5\u7edd\u5927\u591a\u6570CRPC\u60a3\u8005\u5728\u8bca\u65ad\u540e3\u5e74\u5185\u6b7b\u4ea1\uff0c\u4e3a\u89e3\u51b3\u8fd9\u4e00\u96be\u9898\uff0c\u9488\u5bf9&nbsp;CRPC \u60a3\u8005\u7684\u75c5\u56e0\u5b66\u673a\u5236\uff0c\u4e0d\u540c\u7684\u6cbb\u7597\u836f\u7269\u53ca\u65b9\u6848\u4e5f\u5728\u4e0d\u65ad\u63a8\u9648\u51fa\u65b0\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<section label=\"Copyleft 2018 iPaiban All lefts Reserved \uff08\u672c\u6837\u5f0f\u5df2\u505a\u7248\u6743\u4fdd\u62a4\uff0c\u672a\u7ecf\u6b63\u5f0f\u6388\u6743\u4e0d\u5141\u8bb8\u4efb\u4f55\u7b2c\u4e09\u65b9\u7f16\u8f91\u5668\u3001\u4f01\u4e1a\u3001\u4e2a\u4eba\u4f7f\u7528\uff0c\u8fdd\u8005\u5fc5\u7ea0\uff09\" donone=\"shifuMouseDownPayStyle(&#39;shifu_qmi_014&#39;)\" style=\"margin: 0rem auto;white-space: normal;width: 546.828px;border-width: initial;border-color: initial;border-style: none;\">\n<section style=\"margin: 10px auto;width: 546.828px;height: 40px;border-bottom: 1px solid rgb(246, 246, 246);overflow: hidden;color: inherit;background-color: rgb(251, 251, 251);text-align: center;\">\n<section class=\"ipaiban-bg\" style=\"margin-left: 20px;display: inline-block;width: auto;height: 2.5rem;border-radius: 10px 0px;transform: skew(-30deg);color: rgb(255, 255, 255);background-color: rgb(3, 169, 244);\">\n<section style=\"padding-right: 30px;padding-left: 30px;font-size: 1rem;line-height: 2.5rem;color: inherit;transform: skew(30deg);\">\n<p><span style=\"color: rgb(255, 0, 0);background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;font-family: \u5b8b\u4f53;\">\u6069\u6742\u9c81\u80fa\u83b7\u6279\u60c5\u51b5<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6069\u6742\u9c81\u80fa( enzalutamide)\u5176\u4e34\u5e8a\u836f\u7269\u662f\u7531Medivation \u516c\u53f8\u548c\u5b89\u65af\u6cf0\u6765( Astellas) \u516c\u53f8\u5408\u4f5c\u5f00\u53d1\uff0c\u4e8e2012\u5e748 \u670831 \u65e5\u7ecf\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u7ba1\u7406\u5c40( FDA) \u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u5df2\u6269\u6563\u6216\u590d\u53d1\u7684\u665a\u671f\u7537\u6027\u53bb\u52bf\u8010\u53d7\u524d\u5217\u817a\u764c(CRPC) \uff0c\u5546\u54c1\u540d\u4e3aXtandi&nbsp;[1]&nbsp;&nbsp;\uff0c\u8be5\u836f\u4e3a\u53e3\u670d\u5236\u5242\uff0c2018\u5e747\u670813\u65e5\uff0cFDA\u6279\u51c6\u8be5\u836f\u7269\u7528\u4e8e\u975e\u8f6c\u79fb\u6027CRPC\uff08NM-CRPC\uff09\u60a3\u8005\uff0c\u6269\u5927\u4e86\u7528\u836f\u7684\u7fa4\u4f53\u3002\u6069\u6742\u9c81\u80fa\u4e8e2013\u5e746\u6708\u9996\u6b21\u83b7\u5f97EC\u6279\u51c6\uff0c\u7528\u4e8e\u75be\u75c5\u5df2\u6076\u5316\u6216\u96c4\u6fc0\u7d20\u5265\u593a\u6cbb\u7597\uff08ADT\uff09\u5931\u8d25\u540e\u65e0\u75c7\u72b6\u6216\u8f7b\u5ea6\u75c7\u72b6\u6216\u4ee5\u591a\u897f\u4ed6\u8d5b\u6cbb\u7597\u540e\u7684&nbsp;mCRPC \u60a3\u8005\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<section label=\"Copyleft 2018 iPaiban All lefts Reserved \uff08\u672c\u6837\u5f0f\u5df2\u505a\u7248\u6743\u4fdd\u62a4\uff0c\u672a\u7ecf\u6b63\u5f0f\u6388\u6743\u4e0d\u5141\u8bb8\u4efb\u4f55\u7b2c\u4e09\u65b9\u7f16\u8f91\u5668\u3001\u4f01\u4e1a\u3001\u4e2a\u4eba\u4f7f\u7528\uff0c\u8fdd\u8005\u5fc5\u7ea0\uff09\" donone=\"shifuMouseDownPayStyle(&#39;shifu_qmi_014&#39;)\" style=\"margin: 0rem auto;white-space: normal;width: 546.828px;border-width: initial;border-color: initial;border-style: none;\">\n<section style=\"margin: 10px auto;width: 546.828px;height: 40px;border-bottom: 1px solid rgb(246, 246, 246);overflow: hidden;color: inherit;background-color: rgb(251, 251, 251);text-align: center;\">\n<section class=\"ipaiban-bg\" style=\"margin-left: 20px;display: inline-block;width: auto;height: 2.5rem;border-radius: 10px 0px;transform: skew(-30deg);color: rgb(255, 255, 255);background-color: rgb(3, 169, 244);\">\n<section style=\"padding-right: 30px;padding-left: 30px;font-size: 1rem;line-height: 2.5rem;color: inherit;transform: skew(30deg);\">\n<p><span style=\"color: rgb(255, 0, 0);background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;font-family: \u5b8b\u4f53;\">CHMP\u79ef\u6781\u610f\u89c1\u7f18\u7531<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">CHMP\u7684\u89c2\u70b9\u662f\u57fa\u4e8e\u5173\u952e\u76843\u671fPROSPER\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u8fd9\u9879\u7814\u7a76\u4e00\u5171\u62db\u52df\u4e861401\u540d\u60a3\u8005\uff0c\u8be5\u8bd5\u9a8c\u8bc4\u4f30\u4e86enzalutamide\u52a0ADT\u4e0e\u5b89\u6170\u5242\u52a0ADT\u5bf9nmCRPC\u60a3\u8005\u548c\u524d\u5217\u817a\u7279\u5f02\u6027\u6297\u539f\uff08PSA\uff09\u6c34\u5e73\u5feb\u901f\u4e0a\u5347\u7684\u5f71\u54cd,&nbsp;\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u6069\u6742\u9c81\u80fa\u4e0eADT\u6784\u6210\u7684\u7ec4\u5408\u7597\u6cd5\u4e0eADT\u4e0e\u5b89\u6170\u5242\u7ec4\u5408\u7597\u6cd5\u76f8\u6bd4\u663e\u8457\u5ef6\u957f\u60a3\u8005\u7684\u65e0\u8f6c\u79fb\u751f\u5b58\u671f&nbsp;(metastasis free survival, MFS)&nbsp;\uff0c\u8be5\u7ed3\u679c\u7b26\u5408\u65e0\u8f6c\u79fb\u751f\u5b58\uff08MFS\uff09\u7684\u4e3b\u8981\u7ec8\u70b9\u3002\u63a5\u53d7\u6069\u6742\u9c81\u80fa\u52a0ADT\u7684\u7537\u6027\u4e2d\u4f4dMFS\u4e3a36.6\u4e2a\u6708\uff0c\u800c\u5b89\u6170\u5242\u52a0ADT\u7684\u60a3\u8005\u4e3a14.7\u4e2a\u6708\uff08n = 1401; HR = 0.29 [95\uff05CI\uff1a0.24-0.35]; p &lt;0.001\uff09\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">PROSPER\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242\u52a0ADT\u76f8\u6bd4\uff0cnmCRPC\u60a3\u8005\u7684\u653e\u5c04\u5b66\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e71\uff05\uff0cPSA\u6c34\u5e73\u8fc5\u901f\u5347\u9ad8\uff08HR = 0.29 [95\uff05CI\uff1a0.24-0.35]; p &lt;0.001\uff09\uff0c\u4efb\u4f55\u7b49\u7ea7\u5305\u62ecenzalutamide\u52a0ADT\u4e0e\u5b89\u6170\u5242\u52a0ADT\u7684\u6700\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\u662f(\u226510\uff05\u6216\u66f4\u591a\u7684\u60a3\u8005)\uff1a\u75b2\u52b3\uff0833\uff05vs 14\uff05\uff09\uff0c\u70ed\u6f6e\u7ea2\uff0813\uff05vs 8\uff05\uff09\uff0c\u9ad8\u8840\u538b\uff0812\uff05\uff09&nbsp;vs 5\uff05\uff09\uff0c\u6076\u5fc3\uff0811\uff05vs 9\uff05\uff09\uff0c\u8dcc\u5012\uff0811\uff05vs 4\uff05\uff09\uff0c\u5934\u6655\uff0810\uff05vs 4\uff05\uff09\u548c\u98df\u6b32\u4e0b\u964d\uff0810\uff05vs 4\uff05\uff09.\u8fd9\u4e9b\u7ed3\u679c\u53d1\u8868\u4e8e2018\u5e746\u6708\u7684\u201c\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u201d\u3002<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<section label=\"Copyleft 2018 iPaiban All lefts Reserved \uff08\u672c\u6837\u5f0f\u5df2\u505a\u7248\u6743\u4fdd\u62a4\uff0c\u672a\u7ecf\u6b63\u5f0f\u6388\u6743\u4e0d\u5141\u8bb8\u4efb\u4f55\u7b2c\u4e09\u65b9\u7f16\u8f91\u5668\u3001\u4f01\u4e1a\u3001\u4e2a\u4eba\u4f7f\u7528\uff0c\u8fdd\u8005\u5fc5\u7ea0\uff09\" donone=\"shifuMouseDownPayStyle(&#39;shifu_qmi_014&#39;)\" style=\"margin: 0rem auto;white-space: normal;width: 546.828px;border-width: initial;border-color: initial;border-style: none;\">\n<section style=\"margin: 10px auto;width: 546.828px;height: 40px;border-bottom: 1px solid rgb(246, 246, 246);overflow: hidden;background-color: rgb(251, 251, 251);text-align: center;\">\n<section class=\"ipaiban-bg\" style=\"margin-left: 20px;display: inline-block;width: auto;height: 2.5rem;border-radius: 10px 0px;transform: skew(-30deg);background-color: rgb(3, 169, 244);\">\n<section style=\"padding-right: 30px;padding-left: 30px;font-size: 1rem;line-height: 2.5rem;transform: skew(30deg);\">\n<p style=\"\"><span style=\"color:#ff0000;font-family:\u5b8b\u4f53;\">\u5c55\u671b\u672a\u6765<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u5728nmCRPC\u4e2d\uff0c\u9ad8\u98ce\u9669\u60a3\u8005\u6b63\u5904\u4e8e\u764c\u75c7\u53d1\u5c55\u7684\u9636\u6bb5\uff0c\u5c3d\u7ba1\u76ee\u524d\u6fc0\u7d20\u7684\u6cbb\u7597\u6548\u679c\u8fd8\u770b\u4e0d\u51fa\u6765\uff0c\u4f46\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u4f1a\u663e\u73b0\u51fa\u6765\u3002\u8fd9\u4e9b\u60a3\u8005\u65e9\u671f\u4f7f\u7528\u6069\u6742\u9c81\u80fa\u7684\u76ee\u7684\u662f\u5ef6\u8fdf\u8f6c\u79fb\u7684\u51fa\u73b0\uff0c\u6539\u5584\u751f\u6d3b\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\u201d\u7f8e\u56fd\u897f\u5317\u5927\u5b66\u4e2d\u5fc3\u548c\u9996\u5e2d\u7814\u7a76\u5458, \u533b\u5b66\u535a\u58eb, \u533b\u5b66<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6559\u6388<\/span><span style=\"font-size: 15px;\">Maha Hussain<\/span><span style=\"font-size: 15px;\">\u8bf4\u3002<\/span><span style=\"font-size: 15px;\">&nbsp;\u201c<\/span><span style=\"font-size: 15px;\">\u8be5\u75be\u75c5\u9636\u6bb5\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6848\u610f\u5473\u7740\u91cd\u8981\u7684\u6cbb\u7597\u8fdb\u5c55\u3002<\/span><span style=\"font-size: 15px;\">\u201d<\/span><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u8fd9\u4e00\u79ef\u6781\u7684CHMP\u610f\u89c1\u8fc8\u51fa\u4e86\u5411\u4e13\u4e1a\u533b\u7597\u4fdd\u5065\u4e13\u4e1a\u4eba\u5458\u63d0\u4f9bnmCRPC\u60a3\u8005\u548c\u524d\u5217\u817a\u7279\u5f02\u6027\u6297\u539f\u6c34\u5e73\u8fc5\u901f\u4e0a\u5347\u7684\u65b0\u6cbb\u7597\u65b9\u6848\u7684\u91cd\u8981\u4e00\u6b65\u3002\u8fd9\u4e9b\u60a3\u8005\u53d1\u751f\u8f6c\u79fb\u548c\u6b7b\u4ea1\u7684\u98ce\u9669\u8f83\u9ad8\u3002\u5728\u83b7\u5f97EMA\u6279\u51c6\u7684\u60c5\u51b5\u4e0b\uff0c\u6211\u4eec\u6709\u53ef\u80fd\u6269\u5927enzalutamide\u5728\u533b\u7597\u9700\u6c42\u660e\u663e\u672a\u5f97\u5230\u6ee1\u8db3\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\u7684\u4f7f\u7528\u8303\u56f4&nbsp;\u201c\u5b89\u65af\u6cf0\u6765\u80bf\u7624\u5b66\u53d1\u5c55\u9ad8\u7ea7\u526f\u603b\u88c1\u517c\u5168\u7403\u6cbb\u7597\u533a\u8d1f\u8d23\u4ebaSteven Benner\u5148\u751f\u8bf4\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u73b0\u5728\u5c06\u7531\u6b27\u76df\u59d4\u5458\u4f1a\u5ba1\u67e5CHMP\u7684\u79ef\u6781\u610f\u89c1\uff0c\u6b27\u76df\u59d4\u5458\u4f1a\u6709\u6743\u6279\u51c628\u4e2a\u6b27\u76df\u6210\u5458\u56fd\u4ee5\u53ca\u51b0\u5c9b\uff0c\u632a\u5a01\u548c\u5217\u652f\u6566\u58eb\u767b\u7684\u836f\u54c1\u3002EC\u901a\u5e38\u4f1a\u9075\u5faaCHMP\u7684\u5efa\u8bae\uff0c\u9884\u8ba1\u5c06\u57282018\u5e74\u7684\u6700\u540e\u4e00\u4e2a\u5b63\u5ea6\u505a\u51fa\u6700\u7ec8\u51b3\u5b9a\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u53c2\u8003\u6587\u732e:<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 15px;\">Astellas Receives Positive CHMP Opinion for XTANDI\u2122&nbsp;(enzalutamide) for Adult Men with High-Risk Non-Metastatic Castration-Resistant Prostate Cancer<\/span><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6392\u7248\uff1a\u9621\u4e0a\u964c\u964c<\/span><br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<section style=\"font-size: 16px;white-space: normal;max-width: 677px;box-sizing: border-box;word-wrap: break-word;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;\">\n<section style=\"margin-right: 3px;margin-left: 3px;padding: 20px;max-width: 677px;box-sizing: border-box;word-wrap: break-word;background-color: rgb(254, 254, 254);border-color: rgb(210, 150, 20);box-shadow: rgb(210, 150, 20) 0px 0px 4px;\">\n<p style=\"max-width: 631px;box-sizing: border-box;word-wrap: break-word;min-height: 18px;color: rgb(210, 150, 20);font-size: 18px;font-weight: 700;min-width: 1px;\">\u57f9\u8bad\u548c\u4f1a\u8bae\uff1a<\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 595.8px;box-sizing: border-box;word-wrap: break-word;min-height: 17px;color: rgb(6, 6, 6);letter-spacing: 0.54px;\"><span style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;font-size: 15px;\">\u540c\u5199\u610f\u57f9\u8bad<\/span><\/p>\n<\/li>\n<\/ul>\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 631px;box-sizing: border-box;word-wrap: break-word;border-color: rgb(210, 150, 20);\">\n<h2 style=\"max-width: 631px;box-sizing: border-box;word-wrap: break-word;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650624081&amp;idx=1&amp;sn=c5f77cee20dc1335acc21f30ad489921&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box;word-wrap: break-word;\">\u5199\u610f\u5de8\u732e\u4e2830\u4f4d\u4e13\u5bb6\u8bba\u9053\u4e0a\u6d77\u6ee9\uff1a\u65b0\u836f\u4e2d\u7f8e\u53cc\u62a5\u4e4b\u4e34\u5e8a\u7814\u7a76\u5cf0\u4f1a<\/a><\/h2>\n<p style=\"max-width: 631px;box-sizing: border-box;word-wrap: break-word;min-height: 16px;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI5ODI5NDE2OA==&amp;mid=2247497001&amp;idx=1&amp;sn=c6d3e795d153103a34195954e1597758&amp;chksm=ecaabbdedbdd32c80256923d841e8469d77fbd41a885fd17633d55cd43582c0301e12a3acace&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box;word-wrap: break-word;\">\u90b1\u6021\u8679\u7387\u4f17\u5236\u5242\u5927\u5bb6\u8bb2\u6388\u6ee1\u8db3\u4e2d\u7f8e\u53cc\u62a5\u7684\u65b0\u836f\u5236\u5242\u7814\u53d1<\/a><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;\"  \/><\/p>\n<hr style=\"white-space: normal;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/>\n<p style=\"font-size: 16px;white-space: normal;max-width: 677px;box-sizing: border-box;word-wrap: break-word;min-height: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;text-align: center;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;\"  \/><\/p>\n<p style=\"font-size: 16px;white-space: normal;max-width: 677px;box-sizing: border-box;word-wrap: break-word;min-height: 16px;letter-spacing: 0.54px;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: justify;\"><span style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;font-size: 15px;\">\u836f\u4e8b\u7eb5\u6a2a\u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u73b0\u6709\u6210\u545835\u540d\uff0c\u5206\u522b\u4e3aVoyager88\uff0c\u96f7\u8bfa\u5c9b\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0cyhqqqqq\uff0c\u5360\u5c0f\u5175\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0cflydp511\uff0c\u5de7\u5de7\uff0c\u9621\u4e0a\u964c\u964c\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0cKailyn\uff0cSeven\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cVicky\uff0cSophia \uff0c\u4f9d\u7136\u7279\u96f7\u897f\uff0c\u5076\u9635\u96e8\uff0cAimee\uff0c\u4ed6\u5c71\u4e4b\u77f3\uff0c\u96f6\u4e0b274\u2103\uff0cBreathless\uff0cLuffy\uff0c\u80e1\u4e0d\u559c\uff0c&nbsp;Helen\uff0c\u7b49\u7b49\uff0cSUNRISE\uff0cZMJ\uff0c\u6da6\u513f\uff0cJessie<span style=\"letter-spacing: 0.54px;\">\u3001\u4e91\u5377<\/span>\u3002\u6b22\u8fce\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u6211\u4eec\u56e2\u961f\u3002\u6295\u7a3f\u3001\u5408\u4f5c\u3001\u52a0\u4e13\u4e1a\u7fa4\u8bf7\u52a0\u5fae\u4fe1442015666\uff0c\u836f\u4e8b\u7eb5\u6a2a\u4e8c\u5343\u4ebaQQ\u7fa422711855\u3002<\/span><span yahei=\"yahei\" sans=\"sans\" helvetica=\"helvetica\" px=\"px\" gb=\"gb\" neue=\"neue\" none=\"none\" left=\"left\" normal=\"normal\" ui=\"ui\" sc=\"sc\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;display: inline;float: none;\">&nbsp;&nbsp;<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>2018\u5e749\u670824\u65e5,\u5b89\u65af\u6cf0\u6765\u5236\u836f\u516c\u53f8\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98Kenki Yasukawa\u535a\u58eb\u4eca\u5929\u5ba3\u5e03\uff0c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":53715,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/53714"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=53714"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/53714\/revisions"}],"predecessor-version":[{"id":53716,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/53714\/revisions\/53716"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/53715"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=53714"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=53714"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=53714"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}