{"id":53735,"date":"2018-09-26T01:00:00","date_gmt":"2018-09-30T01:48:31","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/lions%e5%85%ac%e5%8f%b8%e6%b2%bb%e7%96%97%e5%bf%83%e8%a1%80%e7%ae%a1%e5%8f%8d%e4%b9%89%e8%8d%af%e7%89%a9%e5%85%ac%e5%b8%832%e6%9c%9f%e4%b8%b4%e5%ba%8a%e7%a7%af%e6%9e%81%e7%bb%93%e6%9e%9c\/"},"modified":"2018-09-30T09:48:32","modified_gmt":"2018-09-30T01:48:32","slug":"lions%e5%85%ac%e5%8f%b8%e6%b2%bb%e7%96%97%e5%bf%83%e8%a1%80%e7%ae%a1%e5%8f%8d%e4%b9%89%e8%8d%af%e7%89%a9%e5%85%ac%e5%b8%832%e6%9c%9f%e4%b8%b4%e5%ba%8a%e7%a7%af%e6%9e%81%e7%bb%93%e6%9e%9c","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/53735\/","title":{"rendered":"Lions\u516c\u53f8\u6cbb\u7597\u5fc3\u8840\u7ba1\u53cd\u4e49\u836f\u7269\u516c\u5e032\u671f\u4e34\u5e8a\u79ef\u6781\u7ed3\u679c"},"content":{"rendered":"
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24\u65e5\uff0c<\/span>Akcea Therapeutics<\/span> \u548c\u5176\u6bcd\u516c\u53f8<\/span> <\/span>Ionis<\/span>\u5236\u836f<\/span>\u4eca\u5929\u516c\u5e03\u4e86<\/span>\u5176\u53cd\u4e49\u836f\u7269<\/span>AKCEA-APO(a)-LRx<\/span>\u5728<\/span>\u4e00\u9879<\/span>\u65e2\u5f80\u5fc3\u8840\u7ba1\u75be\u75c5\uff08CVD\uff09\u548c\u8102\u86cb\u767d\uff08a\uff09<\/span>\uff08<\/span>Lp(a)<\/span>\uff09<\/span>\u6c34\u5e73\u5347\u9ad8<\/span><\/span><\/strong>\u7684\u60a3\u8005\u4e2d\u8fdb\u884c\u76842\u671f\u4e34\u5e8a\u7814\u7a76\u7684<\/span>\u79ef\u6781<\/span>\u7ed3\u679c\u3002<\/span>\u8be5\u7814\u7a76<\/span>\u7684<\/span>\u8be6\u7ec6<\/span>\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u5c06\u57282018\u5e7411\u670810\u65e5\u81f312\u65e5\u5728\u829d\u52a0\u54e5\u4e3e\u884c\u7684\u7f8e\u56fd\u5fc3\u810f\u534f\u4f1a\u79d1\u5b66\u4f1a\u8bae\u4e0a<\/span>\u516c\u5e03<\/span>\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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AKCEA-APO(a)-LRx<\/span>\u662f<\/span> <\/span>Ionis<\/span>\u516c\u53f8\u7684\u53cd\u4e49\u836f\u7269\uff0c\u8be5\u836f\u7269\u80fd\u591f<\/span><\/span><\/strong>\u6291\u5236\u8f7d\u8102\u86cb\u767d\uff08a\uff09\u7684\u4ea7\u751f\uff0c\u4ece\u800c\u51cf\u5c11\u8102\u86cb\u767d\uff08a\uff09<\/span><\/strong>\u3002<\/span>\u8be5<\/span>2\u671f\u4e34\u5e8a\u7814\u7a76\u4e3a<\/span><\/span>\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001<\/span>\u8bc4\u4f30<\/span>\u4e0d\u540c\u5242\u91cf<\/span>AKCEA-APO(a)-LRx<\/span>\u836f\u7269<\/span>\u5728<\/span>286\u540dLp(a)\u6c34\u5e73\u5347\u9ad8\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span>\u3002\u7814\u7a76\u91c7\u7528<\/span>5\u6bd4<\/span>1<\/span>\u7684\u968f\u673a\u8bd5\u9a8c\uff0c\u6d4b\u8bd5\u4e86<\/span>AKCEA-APO(a)-LRx<\/span>\u7684\u4e0d\u540c\u5242\u91cf\u548c\u5242\u91cf\u9891\u7387\u3002\u6bcf\u5468\u3001\u6bcf\u9694\u4e00\u5468\u548c\u6bcf\u6708\u8fdb\u884c\u5242\u91cf\u6d4b\u8bd5\uff0c\u5242\u91cf\u8303\u56f4\u4ece<\/span>20<\/span>mg\u5230<\/span>60mg\u4e0d\u7b49\u3002\u60a3\u8005\u81f3\u5c11\u670d\u7528<\/span>6\u4e2a\u6708\uff0c\u6709\u4e9b\u60a3\u8005\u670d\u7528\u957f\u8fbe\u4e00\u5e74\u3002\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u662f<\/span>Lp(a)<\/span>\u5728\u4e3b\u8981\u5206\u6790\u65f6\u95f4\u70b9<\/span>(6<\/span>\u4e2a\u6708<\/span>)<\/span>\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u7684\u57fa\u7ebf\u53d8\u5316\u767e\u5206\u6bd4\u3002<\/span><\/span><\/p>\n

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\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff1a<\/span><\/strong><\/p>\n


<\/span><\/span><\/p>\n

A\u3001<\/span>\u5728\u6240\u6709\u5242\u91cf\u6c34\u5e73\u4e0a\uff0c\u5305\u62ec\u6bcf\u6708\u4f4e\u5242\u91cf\u7684<\/span>AKCEA-APO(a)-LRx, Lp(a)\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u5747\u6709\u663e\u8457\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u964d\u4f4e\uff1b<\/span><\/span><\/p>\n

B\u3001<\/span>\u6d3b\u6027\u7ec4\u4e2d\u7684\u5927\u591a\u6570\u60a3\u8005\u7684<\/span>Lp\uff08<\/span>a<\/span>\uff09\u964d\u4f4e\u4f4e\u4e8e\u65e2\u5b9a\u7684<\/span>CVD<\/span>\u4e8b\u4ef6\u98ce\u9669\u9608\u503c\uff1b<\/span><\/span><\/p>\n

C\u3001<\/span>\u6cbb\u7597\u4e2d\u7684\u7d27\u6025\u4e0d\u826f\u4e8b\u4ef6\u5728\u6d3b\u6027\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\u4e4b\u95f4\u65e0\u5dee\u5f02\uff1b<\/span><\/span><\/p>\n

D\u3001<\/span>\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u662f\u6ce8\u5c04\u90e8\u4f4d\u53cd\u5e94\uff08<\/span>ISR\uff09<\/span>\uff0c<\/span><\/span> ISR\u4e3b\u8981\u662f\u8f7b\u5fae\u7684\uff0c\u5e76\u4e14\u53d1\u751f\u5728\u5c11\u6570\u60a3\u8005\u4e2d<\/span>\uff1b<\/span><\/span><\/p>\n

E\u3001<\/span>\u7814\u7a76\u4e2d<\/span><\/span>\u65e0<\/span><\/span>\u8840\u5c0f\u677f\u4f4e\u4e8e<\/span>100000 \/ mm<\/span>3<\/span><\/sup>\u6c34\u5e73<\/span><\/span>\u7684<\/span><\/span>\u60a3\u8005\u3002\u4f4e\u4e8e\u6b63\u5e38\u7684\u8840\u5c0f\u677f\u6c34\u5e73\uff08<\/span>140000 \/ mm<\/span>3<\/span><\/sup>\uff09\u7684\u53d1\u751f\u7387\u5728\u6d3b\u6027<\/span><\/span>\u7ec4<\/span><\/span>\uff08<\/span>10.5\uff05\uff09\u548c\u5b89\u6170\u5242\uff0814.9\uff05\uff09\u7ec4\u4e4b\u95f4\u662f\u76f8\u5f53\u7684<\/span>\uff1b<\/span><\/span><\/p>\n

F\u3001<\/span>\u5927\u7ea6<\/span>90%\u7684\u60a3\u8005\u5b8c\u6210\u4e86\u6cbb\u7597\uff0c\u800c\u4e2d\u6b62\u6cbb\u7597\u7684\u6bd4\u4f8b\u5728\u6d3b\u6027\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\u4e2d\u76f8\u5f53\u3002<\/span><\/span><\/p>\n

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Akcea Therapeutics\u9996\u5e2d\u6267\u884c\u5b98Paula Soteropoulos<\/span>\u8868\u793a\uff0c\u8fd9\u4e9b\u6570\u636e\u5bf9\u4e8e\u90a3\u4e9b\u7531\u4e8e\u9ad8<\/span>Lp(a)\u6c34\u5e73\u800c\u6709\u5fc3\u8840\u7ba1\u75be\u75c5\u8fc7\u65e9\u6b7b\u4ea1\u98ce\u9669\u7684\u60a3\u8005\u6765\u8bf4\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u8fdb\u6b65\u3002\u5728\u8fd9\u4e2a\u5927\u578b<\/span><\/span>2<\/span>\u671f\u7814\u7a76\u4e2d\uff0c<\/span>AKCEA-APO(a)-LRx\u80fd\u591f\u7a33\u5065\u5730\u964d\u4f4e<\/span>Lp(a)<\/span>\uff0c\u4e14\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u6b64\u5916\uff0c\u8fd9\u9879\u7814\u7a76\u7684\u6570\u636e\u652f\u6301\u4ee5\u65b9\u4fbf\u3001\u4f4e\u5242\u91cf\u7684\u6708\u5242\u91cf\u6cbb\u7597\u75c5\u4eba\u7684\u6f5c\u529b\u3002<\/span><\/span><\/p>\n

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L<\/span>onis\u4f7f\u7528\u5176\u4e13\u6709\u7684\u914d\u4f53\u5171\u8f6d\u53cd\u4e49<\/span>(LICA)<\/span>\u6280\u672f\u53d1\u660e\u4e86<\/span>Akcea – apo (a)-LRx<\/span>\uff0c\u5e76\u4e0e<\/span>Akcea<\/span>\u5171\u540c\u5f00\u53d1\u4e86\u8be5\u836f\u7269\u3002<\/span><\/span>\u8be5\u836f\u7269\u662f<\/span>Akcea\u4e0e\u8bfa\u534e\u516c\u53f8\u6218\u7565\u5408\u4f5c\u7684\u4e00\u90e8\u5206\u3002\u636e\u6089\uff0c<\/span><\/span>\u5982\u679c\u8bfa\u534e\u5728\u6210\u529f\u5b8c\u6210\u4e0e<\/span>FDA\u7684\u7b2c<\/span>2<\/span>\u9636\u6bb5\u4f1a\u8bae\u540e\uff0c\u884c\u4f7f\u8bb8\u53ef<\/span>Akcea – apo (a)-LRx<\/span>\u7684\u9009\u62e9\u6743\uff0c<\/span>Akcea<\/span>\u5c06\u83b7\u5f97<\/span>1.5<\/span>\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u5f0f\u4ed8\u6b3e\uff0c\u5176\u4e2d<\/span>50%<\/span>\u5c06\u652f\u4ed8\u7ed9<\/span>Ionis<\/span>\u3002\u4e4b\u540e\uff0c\u8bfa\u534e\u5c06\u8d1f\u8d23<\/span><\/span>\u8be5\u836f<\/span><\/span>\u6240\u6709\u672a\u6765\u7684\u5f00\u53d1\uff0c\u5305\u62ec\u76ee\u524d\u8ba1\u5212\u7684\u5168\u7403<\/span>3\u671f\u5fc3\u8840\u7ba1\u7ed3\u5c40\u7814\u7a76\uff0c\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0c\u5c06\u8d1f\u8d23\u5168\u7403\u5546\u4e1a\u5316\u6d3b\u52a8\u3002<\/span><\/span><\/p>\n

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\u5173\u4e8e\u53cd\u4e49\u836f\u7269<\/span><\/strong><\/span><\/p>\n

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\u53cd\u4e49\u836f\u7269<\/span><\/span>\uff0c\u901a\u5e38\u662f\u6307\u53cd\u4e49\u5be1\u6838\u82f7\u9178\uff0c\u5373\u4eba\u5de5\u5408\u6210\u7684<\/span>DNA\u6216<\/span>RNA<\/span>\u5355\u94fe\u7247\u6bb5\uff0c<\/span><\/span>\u662f\u8fd1\u4e9b\u5e74\u6765\u53d1\u5c55\u7684\u4e00\u79cd\u5168\u65b0\u7684\u836f\u7269\u8bbe\u8ba1\u65b9\u6cd5\uff0c\u4e3b\u8981\u662f\u6839\u636e\u78b1\u57fa\u4e92\u8865\u914d\u5bf9\u539f\u5219\u548c\u6838\u9178\u6742\u4ea4\u539f\u7406\uff0c\u5229\u7528\u4eba\u5de5\u5408\u6210\u3001\u5929\u7136\u5b58\u5728\u7684\u4e92\u8865\u5be1\u6838\u82f7\u9178\u7247\u6bb5\uff0c\u4e0e\u76ee\u7684\u57fa\u56e0<\/span>(\u5355\u94fe\u3001\u53cc\u94fe<\/span>DNA)<\/span>\u6216\u4fe1\u4f7f\u6838\u7cd6\u6838\u9178<\/span>(mRNA)<\/span>\u7684\u7279\u5b9a\u5e8f\u5217\u76f8\u7ed3\u5408\uff0c\u4ece\u57fa\u56e0\u590d\u5236\u3001\u8f6c\u5f55\u3001\u526a\u63a5\u3001\u8f6c\u8fd0\u7ffb\u8bd1\u7b49\u6c34\u5e73\u4e0a\u8c03\u8282\u9776\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u5e72\u6270\u9057\u4f20\u4fe1\u606f\u4ece\u6838\u9178\u5411\u86cb\u767d\u8d28\u7684\u4f20\u9012\uff0c\u4ece\u800c\u8fbe\u5230\u6291\u5236\u3001\u5c01\u95ed\u6216\u7834\u574f\u9776\u57fa\u56e0\u7684\u76ee\u7684\u3002<\/span><\/span>\u4f20\u7edf\u836f\u7269\u4e3b\u8981\u662f\u76f4\u63a5\u4f5c\u7528\u4e8e\u81f4\u75c5\u86cb\u767d\u672c\u8eab<\/span> ,\u53cd\u4e49\u836f\u7269\u5219\u4f5c\u7528\u4e8e\u4ea7\u751f\u86cb\u767d\u7684\u57fa\u56e0 <\/span>,<\/span>\u56e0\u6b64\u53ef\u5e7f\u6cdb\u5e94\u7528\u4e8e\u591a\u79cd\u75be\u75c5\u7684\u6cbb\u7597 <\/span>,<\/span>\u5982\u4f20\u67d3\u75c5\u3001\u708e\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u53ca\u80bf\u7624\u7b49\u3002\u4e0e\u4f20\u7edf\u836f\u7269\u6bd4\u8f83\u53cd\u4e49\u836f\u7269\u66f4\u5177\u6709\u9009\u62e9\u6027 <\/span>,<\/span>\u56e0\u6b64\u4e5f\u66f4\u9ad8\u6548\u4f4e\u6bd2\u3002<\/span><\/span><\/strong><\/p>\n

 <\/span><\/strong><\/p>\n

\u5173\u4e8e<\/span>Lp(a)<\/span><\/strong><\/span><\/p>\n

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Lp(a)\u5347\u9ad8\u662f\u5fc3\u8840\u7ba1\u75c5\u7684\u72ec\u7acb\u7684\u9057\u4f20\u98ce\u9669\u56e0\u7d20\uff0c\u4e0d\u80fd\u901a\u8fc7\u8c03\u6574\u751f\u6d3b\u65b9\u5f0f<\/span>(<\/span>\u5982\u996e\u98df\u6216\u953b\u70bc<\/span>)<\/span>\u6216\u4f7f\u7528\u73b0\u6709\u7684\u964d\u80c6\u56fa\u9187\u7597\u6cd5\u8fdb\u884c\u6cbb\u7597\u6765\u5f88\u597d\u5730\u63a7\u5236\u3002\u636e\u4f30\u8ba1\uff0c\u6709<\/span>800<\/span>\u4e07\u5230<\/span>1000<\/span>\u4e07\u4eba\u60a3\u6709\u7531<\/span>Lp(a)<\/span>\u6c34\u5e73\u5347\u9ad8\u5f15\u8d77\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\u3002<\/span>AKCEA-APO(a)-LRx<\/span>\u7684<\/span>2<\/span>\u671f\u4e34\u5e8a\u7814\u7a76\u662f\u4e13\u95e8\u9488\u5bf9<\/span>Lp(a)<\/span>\u5347\u9ad8\u60a3\u8005\u8fdb\u884c\u7684\u6700\u5927\u7684\u7814\u7a76\u3002<\/span><\/span><\/p>\n

 <\/span><\/strong><\/p>\n

\u5173\u4e8e<\/span><\/strong>Lonis<\/span><\/span><\/p>\n

 <\/span><\/p>\n

Ionis\u662f<\/span>RNA<\/span>\u9776\u5411\u836f\u7269\u7814\u53d1\u9886\u57df\u7684\u9886\u5148\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u4e3a\u90a3\u4e9b\u533b\u7597\u9700\u6c42\u6700\u9ad8\u7684\u60a3\u8005\u5f00\u53d1\u836f\u7269\uff0c\u4f8b\u5982\u90a3\u4e9b\u60a3\u6709\u4e25\u91cd\u548c\u7f55\u89c1\u75be\u75c5\u7684\u60a3\u8005\u3002<\/span><\/span>\u4f7f\u7528\u5176\u4e13\u6709\u7684\u53cd\u4e49\u6280\u672f<\/span><\/span>\uff0c\u521b\u9020\u4e86\u5927\u91cf<\/span><\/span> <\/span>first-in-class<\/span> <\/span>\u6216\u8005<\/span><\/span>best-in-class<\/span>\u7684\u836f\u7269\uff0c\u6709\u7ea6<\/span>40\u591a\u79cd\u836f\u7269\u6b63\u5728\u7814\u53d1\u4e2d\u3002<\/span><\/span><\/p>\n


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\u6392\u7248\uff1aHerman<\/span><\/p>\n

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\u57f9\u8bad\u548c\u4f1a\u8bae\uff1a<\/p>\n