{"id":54571,"date":"2018-09-26T01:00:00","date_gmt":"2018-09-30T01:57:12","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/proqr-rna-editing\/"},"modified":"2018-09-30T09:57:18","modified_gmt":"2018-09-30T01:57:18","slug":"proqr-rna-editing","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/54571\/","title":{"rendered":"ProQR-RNA editing"},"content":{"rendered":"
\n

\u4f5c\u8005 l MT<\/span><\/strong><\/p>\n

\u7f16\u8f91 l \u7ec6\u80de\u623f<\/span><\/strong><\/p>\n


<\/span><\/p>\n

2018\u5e749\u67085\u65e5\uff0cProQR\u516c\u53f8\u5ba3\u5e03\u4e3b\u6253\u4ea7\u54c1QR-110\u5728\u6cbb\u7597LCA\uff08Leber’s\u5148\u5929\u6027\u9ed1\u6726\uff09\u7684phase I\/II\u4e2d\u671f\u4e34\u5e8a\u7ed3\u679c\u663e\u793a\uff0c\u5bf9\u60a3\u8005\u89c6\u529b\u51c6\u786e\u5ea6\uff0c\u773c\u7403\u8f6c\u52a8\uff0c\u611f\u5149\uff08<\/span>\u7ea2\u84dd\u5149\u523a\u6fc0\uff09\u548c\u773c\u7403\u9707\u98a4\uff08Visualacuity, mobility course, full field stimulus test, ocular instability\uff09\u90fd\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u63d0\u9ad8\uff0c\u5e76\u65e0\u4e0d\u826f\u53cd\u5e94\u3002\u542f\u52a8II\/III\u671f\u4e34\u5e8a\uff0c\u5f53\u5929\u80a1\u4ef7\u4e0a\u6da8120%\u3002<\/span><\/p>\n

\"ProQR-RNA<\/p>\n


<\/p>\n

ProQR\u7684\u6280\u672f\u5e73\u53f0\u4f7f\u7528\u53cd\u4e49\u5be1\u6838\u7518\u9178\u4f5c\u4e3aguide RNA\uff0c\u901a\u8fc7RNA-editing\u7684\u673a\u5236\u4ecemRNA\u7f16\u8f91\u5c42\u9762\u6cbb\u7597\u7531\u57fa\u56e0\u7a81\u53d8\u5bfc\u81f4\u7684\u75be\u75c5\u3002\u7ba1\u7ebf\u4e2d\u76ee\u524d\u6709\u56db\u4e2a\u4ea7\u54c1\uff1aQR-110\u3001QR-331\u3001QR-421a\u548cQR-010\uff0c\u6b64\u5916\u8fd8\u6709\u76f8\u5bf9\u65e9\u671f\u7684QR-411\u3001QRX-504\u3001QRX-704\u548cQR1011\u3002\u8fd9\u91cc\u5c0f\u7f16\u4f1a\u9009\u62e9QR-110\u548cQR-010\u6765\u4ecb\u7ecd\uff0c\u4e24\u8005\u4f7f\u7528\u4e0d\u540c\u673a\u5236\uff0c\u5206\u522b\u4ee3\u8868\u5355\u78b1\u57fa\u7684\u66ff\u6362\u548c\u78b1\u57fa\u7684\u63d2\u5165\u3002<\/span><\/p>\n

\"ProQR-RNA<\/p>\n


<\/span><\/p>\n

\u7528\u4e8e\u6cbb\u7597LCA\u7684QR-110<\/span><\/strong> <\/span><\/p>\n

LCA\uff08Leber’s \u5148\u5929\u6027\u9ed1\u6726\uff09<\/span><\/strong>\u662f\u4e00\u79cd\u53ef\u53d8\u526a\u5207\u9519\u8bef\u5bfc\u81f4\u9057\u4f20\u75c5\uff0c\u662f\u513f\u7ae5\u9057\u4f20\u6027\u5931\u660e\u7684\u6700\u5e38\u89c1\u539f\u56e0\uff0c\u6b27\u7f8e\u6709\u5927\u7ea615,000\u540d\u60a3\u8005\u3002LCA\u60a3\u8005\u7684CEP290\u86cb\u767d\u8d28\u4e2d\u7684Cys998X\u7a81\u53d8\uff08\u5bf9\u5e94\u78b1\u57fac.2991 + 1655A> G\u7a81\u53d8\uff09\uff0c\u7a81\u53d8\u4f4d\u7f6e\u4e3aexon 26\u548cexon 27\u4e4b\u95f4\uff0c\u5bfc\u81f4\u5185\u542b\u5b50\u6ede\u7559\uff0c\u4ea7\u751f\u65e0\u610f\u4e49\u7684\u86cb\u767d\u8d28\u3002CEP290\u7684\u7a81\u53d8\u4f7f\u8fde\u63a5\u89c6\u690e\u548c\u89c6\u6746\u7ec6\u80de\u4e4b\u95f4\u7684\u7ea4\u6bdb\u751f\u957f\u969c\u788d\uff0c\u5f71\u54cd\u89c6\u529b\u3002\u60a3\u8005\u901a\u5e38\u5728\u51fa\u751f\u540e2\u52303\u4e2a\u6708\u51fa\u73b0\u75c7\u72b6\uff0c\u9010\u6e10\u4e27\u5931\u89c6\u529b\uff0c\u76ee\u524d\u5c1a\u65e0\u4e34\u5e8a\u6279\u51c6\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n

\"ProQR-RNA<\/p>\n

\"ProQR-RNA<\/p>\n


<\/span><\/p>\n

QR-110<\/span><\/strong>\u662f\u4e00\u6bb5\u53cd\u4e49\u6838\u7518\u9178\uff0c\u4ecb\u5bfc\u53d1\u751f\u78b1\u57fa\u7a81\u53d8\u7684mRNA\u8fdb\u884c\u201c\u56de\u590d\u7a81\u53d8\u201d\uff0c\u901a\u8fc7\u6ce8\u5c04\u5230\u773c\u775b\u7684\u73bb\u7483\u4f53\u5185\u8fdb\u884c\u7ed9\u836f\u3002\u4e0b\u56fe\u6458\u81ea\u516c\u53f8\u5b98\u7f51\u53d1\u5e03\u7684poster\uff0c\u4e34\u5e8a\u524d\u7684\u5b9e\u9a8c\u9a8c\u8bc1\u663e\u793aQR-110\u53ef\u4ee5\u51cf\u5c11\u7a81\u53d8mRNA\u7684\u8868\u8fbe\uff0c\u63d0\u9ad8\u91ce\u751f\u578b\uff08\u6b63\u5e38\uff09CEP290 mRNA\u53ca\u86cb\u767d\u8d28\u7684\u8868\u8fbe\u3002\u516c\u53f8\u5de7\u5999\u7684\u4f7f\u7528iPSC\u5efa\u7acb\u7684\u89c6\u690e\u7ec6\u80de\u663e\u793aQR-110\u6709\u52a9\u4e8e\u5176\u7ea4\u6bdb\u7684\u751f\u957f\uff08\u957f\u5ea6\uff09\uff0c\u5e76\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u9a8c\u8bc1\u3002<\/span><\/p>\n

\"ProQR-RNA<\/p>\n


<\/p>\n

\"ProQR-RNA<\/p>\n


<\/p>\n

\"ProQR-RNA<\/p>\n

<\/span>
<\/p>\n

\u4eca\u5e749\u67085\u53f7\u516c\u5e03\u7684phase I\/II\u4e2d\u671f\u4e34\u5e8a\u7ed3\u679c\u663e\u793a\uff0c\u5728\u89c6\u529b\u51c6\u786e\u5ea6\u7684\u8bc4\u4f30\u4e0a\uff0c\u4f7f\u7528\u4f2f\u514b\u5229\u521d\u7ea7\u89c6\u529b\u6d4b\u8bd5\uff08BRVT\uff09\u548c\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\u65e9\u671f\u6cbb\u7597\uff08ETDRS\uff09\u89c6\u529b\u8868\u6253\u5206\uff0c\u6700\u4f73\u77eb\u6b63\u89c6\u529b\uff08BCVA\uff09\u5e73\u5747\u6539\u5584\u4e3a-0.67 LogMAR\uff08SEM 0.32\uff09\uff0c62.5\uff05\u7684\u53d7\u8bd5\u8005\u663e\u793a\u4ece\u57fa\u7ebf\u6539\u5584\u5927\u4e8e-0.3 LogMAR\u3002\u773c\u7403\u79fb\u52a8\u7684\u5e73\u5747\u6539\u5584\u4e3a2.6\u7ea7\uff08SEM 1.2\uff09\uff0c57.1\uff05\u7684\u53d7\u8bd5\u8005\u6539\u5584\u8d85\u8fc72.0\u7ea7\u3002\u7ea2\u5149\u7075\u654f\u5ea6\u7684\u5e73\u5747\u6539\u5584\u4e3a-0.74log Cd \/ m2\uff08SEM 0.35\uff09\uff0c\u84dd\u5149\u7075\u654f\u5ea6\u7684\u6539\u5584\u4e3a-0.91log Cd \/ m2\uff08SEM 0.38\uff09\u3002\u6b64\u5916\uff0c\u60a3\u8005\u7684\u773c\u7403\u9707\u98a4\u5f97\u5230\u6539\u5584\uff0c\u4e14\u76ee\u524d\u8010\u53d7\u6027\u826f\u597d\uff0c\u65e0\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff0c\u5bf9\u8fdb\u4e00\u6b65\u7684\u5242\u91cf\u9012\u589e\u6216\u513f\u79d1\u5242\u91cf\u6ca1\u6709\u9650\u5236\u3002<\/span><\/p>\n


<\/p>\n

ADAR\u673a\u5236<\/span><\/strong><\/p>\n

\"ProQR-RNA<\/p>\n


<\/span><\/p>\n

A-to-I RNA\u7f16\u8f91\u662f\u4e00\u79cd\u8f6c\u5f55\u540e\u4fee\u9970\uff0c\u53ef\u5c06RNA\u7684\u817a\u82f7\uff08A\uff09\u8f6c\u6362\u4e3a\u808c\u82f7\uff08I\uff09\u975e\u7f16\u7801RNA\u8f6c\u5f55\u672c\u3002\u7531ADAR\uff08RNA\u817a\u82f7\u8131\u6c28\u9176\uff09\u50ac\u5316\uff0c\u53ef\u4ee5\u5728\u8f6c\u5f55\u540e\u6539\u53d8\u5bc6\u7801\u5b50\uff0c\u5f15\u5165\u6216\u53bb\u9664\u526a\u63a5\u4f4d\u70b9\uff0c\u6216\u5f71\u54cdRNA\u5206\u5b50\u4e0e\u5176\u81ea\u8eab\u6216\u4e0e\u5176\u4ed6RNA\u7684\u78b1\u57fa\u914d\u5bf9\uff0c\u76f8\u6bd4\u591a\u78b1\u57fa\u63d2\u5165\u673a\u5236\u7814\u7a76\u76f8\u5bf9\u6e05\u695a\u3002<\/span><\/p>\n

\"ProQR-RNA<\/p>\n


<\/span><\/p>\n

ADAR\u5df2\u88ab\u8bc1\u660e\u6709\u52a9\u4e8e\u7f16\u8f91ApoB\u548cGluR\u7684pre-mRNA\uff0c\u76ee\u524d\u4e0eA-to-I RNA\u7f16\u8f91\u76f8\u5173\u7684\u75be\u75c5\u89c1\u4e0b\u9762\u5217\u8868\uff0c\u5305\u62ec\u764c\u75c7\uff0c\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7b49\u3002ADAR\u9664\u4e86\u5bf9pre-mRNA\u6709\u7f16\u8f91\u4f5c\u7528\u5916\uff0c\u4e5f\u6709\u7814\u7a76\u53d1\u73b0\u53ef\u4f5c\u7528\u4e8etRNA\u3002<\/span><\/p>\n

\u88681 A-to-I RNA\u7f16\u8f91\u4e3b\u8981\u7814\u7a76\u548c\u4eba\u7c7b\u76f8\u5173\u75be\u75c5<\/span><\/p>\n

\"ProQR-RNA<\/p>\n

<\/span>
<\/p>\n

\u7528\u4e8e\u6cbb\u7597CF\u7684QR-010<\/span><\/strong><\/p>\n

\u56ca\u6027\u7ea4\u7ef4\u5316\uff08Cystic fibrosis\uff0cCF\uff09\u662f\u4e00\u79cd\u7531CFTR\u7a81\u53d8\u5bfc\u81f4\u7684\u9690\u5f62\u9057\u4f20\u6027\u75be\u75c5\uff0c90%\u7684\u60a3\u8005\u643a\u5e26F508del\u7684CFTR<\/em>\u57fa\u56e0\u3002CFTR\u86cb\u767d\u662f\u4e00\u4e2a\u6c2f\u79bb\u5b50\u901a\u9053\uff0c\u63a7\u5236Cl-\u548cHCO3-\u7684\u901a\u8fc7\uff0cCFTR\u529f\u80fd\u7f3a\u9677\u4f1a\u5f71\u54cd\u4e0a\u76ae\u7ec4\u7ec7\u7684pH\u503c\uff0c\u76d0\u548c\u6c34\u7684\u5e73\u8861\u3002\u7531\u4e8eCFTR\u4e3b\u8981\u8868\u8fbe\u5728\u4e0a\u76ae\u7ec6\u80de\uff0c\u56e0\u6b64\u6709\u4e0a\u76ae\u7ec6\u80de\u7ec4\u6210\u5668\u5b98\u90fd\u4f1a\u53d7\u5230\u5f71\u54cd\uff0c\u662f\u4e00\u79cd\u7cfb\u7edf\u6027\u75be\u75c5\uff0c\u4f46\u5927\u90e8\u5206\u53bb\u4e16\u7684\u60a3\u8005\u662f\u7531\u4e8e\u80ba\u90e8\u611f\u67d3\u6216\u80ba\u7ea4\u7ef4\u5316\uff0c\u901a\u5e38\u4e5f\u4f1a\u628aCF\u53eb\u80ba\u56ca\u7ea4\u7ef4\u5316\u3002\u6bcf\u5e74\u67092000\u4e2a\u65b0\u589e\u60a3\u8005\uff0c\u4e3b\u6253\u6cbb\u7597CF\u4ea7\u54c1\u7684Vertex\u5e02\u503c450\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

\"ProQR-RNA<\/p>\n


<\/span><\/p>\n

QR-010\u7684\u8bbe\u8ba1\u7b80\u5355\uff0c\u9488\u5bf9CFTR\u7684mRNA\u7684508\u4f4d\u7f3a\u5931\u7684CUU\u5bf9\u5e94\u589e\u52a0\u4e86GAA\u3002\u52a8\u7269\u6a21\u578b\u7684\u7ed9\u836f\u65b9\u5f0f\u4e3asalin buffer\u6eb6\u89e3\u7684QR-010\u80ba\u90e8\u55b7\u96fe\u7ed9\u836f\uff0c\u5b9e\u9a8c\u53d1\u73b0QR-010\u53ef\u4ee5\u5747\u5300\u7684\u5206\u6563\u5728\u4e0a\u76ae\u7ec4\u7ec7\u8868\u9762\u7684\u7c98\u6db2\u4e2d\uff0c\u5e76\u8fdb\u5165\u4e0a\u76ae\u7ec6\u80de\u3002\u5c0f\u7f16\u4e5f\u662f\u5f88\u8be7\u5f02\uff0c\u65e9\u5e74CF\u7814\u7a76\u4e2d\u4f7f\u7528\u75c5\u6bd2\u643a\u8f7d\u5168\u957fCFTR\u7684\u7b2c\u4e00\u4e2a\u58c1\u5792\u5c31\u662f\u7a7f\u8fc7CF\u60a3\u8005\u80ba\u90e8\u7c98\u7a20\u7684\u75f0\u6db2\u5bfc\u81f4\u75c5\u6bd2\u4fb5\u67d3\u6548\u7387\u5f88\u4f4e\u3002<\/strong><\/span><\/p>\n

\"ProQR-RNA<\/p>\n


<\/span><\/p>\n

\u76ee\u524d\uff0c\u53ea\u5728\u591a\u5934\u7ed2\u6ce1\u83cc\uff08P.Polycephalum\uff09\u548c\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u7684\u7ebf\u7c92\u4f53\u4e2d\u5b58\u5728\u53ef\u5b9e\u73b0\u591a\u78b1\u57fa\u63d2\u5165\u7684\u590d\u5408\u7269\uff0c\u8517\u7cd6\u68af\u5ea6\u79bb\u5fc3\u53d1\u73b0\u590d\u5408\u7269\u591a\u4e3a20S\u3002\u81f3\u4e8eQR-010\u4f5c\u7528\u662f\u5982\u4f55\u5728\u4e0a\u76ae\u7ec6\u80de\u7684\u80de\u8d28\u5185\u5b8c\u6210\uff0c\u5f88\u96be\u53bb\u8bf4\uff0c\u4ece\u673a\u5236\u6216\u8005\u5206\u5b50\u6c34\u5e73\u9a8c\u8bc1\u6765\u770b\uff0c\u6bd5\u7adf\u516c\u53f8\u5e76\u4e0d\u50cfQR-110\u90a3\u6837\u516c\u5e03\u5bf9\u6b63\u5e38mRNA\u548c\u86cb\u767d\u8d28\u6539\u53d8\u7684\u8bc1\u636e\u3002\u8fd9\u91cc\u60f3\u5230\u6709\u5b9e\u9a8c\u5ba4\u91cd\u590d\u97e9\u6625\u96e8\u4e4b\u524d\u7684\u7ed3\u679c\u53d1\u73b0\uff0cAgo\u4e0d\u662f\u53c2\u4e0eDNA\u7f16\u8f91\uff08\u526a\u5207\uff09\uff0c\u800c\u662fRNA\uff0c\u8fd9\u91cc\u4e5f\u53ea\u662f\u79d1\u7814\u6ca1\u6709\u8ddf\u4e0a\u4e34\u5e8a\u5e94\u7528\u7684\u811a\u6b65\u3002\u8fd9\u91cc\u5c0f\u7f16\u5f97\u91c7\u53d6\u4e0d\u770b\u673a\u5236\u770b\u7597\u6548\u7684\u6001\u5ea6\uff0c\u5df2\u5f00\u5c55\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u90e8\u5206\u7ed3\u679c\u663e\u793a\uff0c\u57286.25\uff0c12.5\uff0c25mg\u548c50mg\u7684\u5242\u91cf\u7ec4\u4e2d\u4f7f\u7528ppFEV\uff08\u547c\u6c14\u5230\u5e95\u6d4b\u7684\u80ba\u6d3b\u91cf\uff09\u4e3a\u68c0\u67e5\u6807\u51c6\uff0c\u524d\u4e09\u4e2a\u5242\u91cf\u663e\u793a\u4e00\u5b9a\u6548\u679c\u3002<\/span><\/p>\n

\"ProQR-RNA<\/p>\n


<\/span><\/p>\n

\u53c2\u8003\u6587\u732e<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

1. ProQR\u5b98\u7f51\uff08poster & publication\uff09<\/span><\/p>\n

Exploratory immune assaysdistinguish healthy volunteer from CF patient cohorts and were validated in adose escalation study of eluforsen (QR-010) in subjects with cystic fibrosishomozygous for the F508del CFTR mutation<\/span><\/p>\n

A Phase 1b, Dose-escalation Studyof QR-010, a Novel Antisense Oligonucleotide Administered in Subjects withCystic Fibrosis Homozygous for the F508del CFTR Mutation<\/span><\/p>\n

QR-010 via inhalation is safe,well-tolerated, and achieves systemic concentrations in a single ascending dosestudy in subjects with cystic fibrosis homozygous for the F508del CFTR mutation<\/span><\/p>\n

QR-010 Significantly Improves CFTRfunction in Nasal Potential Difference Proof of Concept Study in Subjects withCF Homozygous for the F508del-CFTR mutation<\/span><\/p>\n

QR-010 Penetrates the Mucus Barrierin Vitro and in Vivo<\/span><\/p>\n

QR-110 Restores CEP290 in p.Cys998X(c.2991+1655A>G) LCA 10 Models<\/span><\/p>\n

QR-110 Treatment for Leber\u2019sCongenital Amaurosis Type 10: Restoration of CEP290 Levels in Optic Cup andFibroblast Models<\/span><\/p>\n

QR-110 treatment for Leber\u2019s congenitalamaurosis Type 10: Investigation of in vitro restoration of CEP290 levels andin vivo delivery of the oligonucleotide to the outer nuclear layer<\/span><\/p>\n

2. Slotkin W, Nishikura K. Adenosine-to-inosine RNA editing and human disease[J]. Genome medicine, 2013, 5(11): 105.<\/span><\/span><\/p>\n

3. Ruslan Aphasizhev, et al. A 100-kD complex of two RNA-binding proteins from mitochondria of Leishmania tarentolae catalyzes RNA annealing and interacts with several RNA editing components[J]. Rna, 2003, 9(1): 62-76.<\/span><\/span><\/p>\n

4. Ruslan Aphasizhev, et al. Isolation of a U\u2010insertion\/deletion editing complex from Leishmania tarentolae mitochondria[J]. The EMBO Journal, 2003, 22(4): 913-924.<\/span><\/span><\/p>\n

5. Maas S, Rich A. Changing genetic information through RNA editing[J]. Bioessays, 2000, 22(9): 790-802.<\/span><\/span><\/p>\n


<\/p>\n

\u6b22\u8fce\u548c\u6211\u4eec\u4e00\u8d77\u53d1\u73b0\u6297\u4f53\u6e90\u52a8\u529b\uff0c\u201c<\/span><\/strong><\/span>\u9605\u8bfb\u539f\u6587<\/span><\/strong>\u201d\u62a5\u540d\u53c2\u52a0\u6297\u4f53\u836f\u7814\u53d1\u8bfe\u7a0b<\/span><\/strong><\/p>\n


<\/span><\/strong><\/span><\/p>\n

\"ProQR-RNA<\/p>\n

\u6b22\u8fce\u52a0\u5165\u5c0f\u7f16\u56e2\u961f\u6210\u4e3a\u5c0f\u7f16\u4e00\u5458<\/strong><\/span>
<\/p>\n

\u8bf7\u52a0\u5c0f\u7f16\u5fae\u4fe1\u53f7\uff1awuwenjun7237<\/span><\/strong><\/span><\/p>\n

\u5982\u6709\u6280\u672f\u89e3\u8bfb\u3001\u884c\u4e1a\u6d1e\u89c1\u613f\u610f\u5206\u4eab<\/span><\/strong><\/span><\/p>\n

\u6b22\u8fce\u6295\u7a3f\u5230\u5c0f\u7f16\u90ae\u7bb1\uff1awuwj06@163.com<\/strong><\/span><\/strong><\/span><\/strong><\/span><\/span><\/span><\/strong><\/p>\n

\"ProQR-RNA
<\/p>\n

\n
\n
\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
<\/section>\n
<\/section>\n<\/section>\n
\n
\n
<\/span><\/strong><\/span>\u7248<\/section>\n<\/section>\n
\n
\u6743<\/section>\n<\/section>\n
\n
\u58f0<\/section>\n<\/section>\n
\n
\u660e<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u5206\u4eab\u3002\u5176\u4ed6\u4efb\u4f55\u5a92\u4f53\u3001\u7f51\u7ad9\u5982\u9700\u8f6c\u8f7d\u6216\u5f15\u7528\u672c\u7f51\u7248\u6743\u6240\u6709\u5185\u5bb9\u987b\u83b7\u5f97\u6388\u6743\u4e14\u5728\u9192\u76ee\u4f4d\u7f6e\u5904\u6ce8\u660e\u201c\u8f6c\u81ea\uff1a\u751f\u7269\u5236\u836f\u5c0f\u7f16\u201d\u3002<\/span><\/p>\n

\n
\n
<\/section>\n
<\/section>\n
<\/section>\n<\/section>\n
\n
\n


\u575a\u6301\u539f\u521b\u3001\u575a\u6301\u4e13\u4e1a<\/strong><\/span><\/p>\n

\u6b22\u8fce\u5173\u6ce8<\/strong><\/span>\u751f\u7269\u5236\u836f\u5c0f\u7f16<\/strong><\/span><\/span><\/p>\n

\u6295\u7a3f\u4fe1\u7bb1\uff1awuwj06@163.com<\/span><\/p>\n

\u5c0f\u7f16\u56e2\u961f\u73b0\u670921\u4f4d\u6210\u5458\uff1a<\/strong><\/span><\/span><\/p>\n

Armstrong\u3001\u533b\u836f\u5c40\u5916\u4eba\u3001Fairy\u3001<\/span>Jone\u3001<\/span>\u4e1c\u80dc\u897f\u725b\u3001Alpharesearcher\u3001MT\u3001\u767e\u8349\u3001Irene\u3001<\/span>Self Renew\u3001\u86cb\u767d\u5de5\u4eba\u3001At.Zhou\u3001Julia\u3001\u6e38\u65b9\u548c\u5c1a\u3001Grand\u3001\u5915\u9633\u6b66\u58eb\u3001\u5403\u74dc\u7fa4\u4f17\u3001Nathan\u3001\u795e\u7ecf\u5143\u3001Clear\u516e\u3001\u5357\u5c71\u5357<\/span><\/span><\/p>\n

\u6b22\u8fce\u6709\u5171\u540c\u5174\u8da3\u7684\u670b\u53cb\u52a0\u5165<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n

\n
<\/section>\n
<\/section>\n<\/section>\n<\/section>\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u4f5c\u8005 l MT \u7f16\u8f91 l \u7ec6\u80de\u623f 2018\u5e749\u67085\u65e5\uff0cProQR\u516c\u53f8\u5ba3\u5e03\u4e3b\u6253\u4ea7\u54c1QR-110\u5728\u6cbb\u7597L […]<\/p>\n","protected":false},"author":1,"featured_media":54572,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/54571"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=54571"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/54571\/revisions"}],"predecessor-version":[{"id":54588,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/54571\/revisions\/54588"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/54572"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=54571"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=54571"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=54571"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}