{"id":54616,"date":"2018-09-29T01:00:00","date_gmt":"2018-09-30T01:57:33","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e3%80%90%e6%9c%89%e6%9c%ba%e3%80%91%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9albomycins-%ce%b41-%ce%b42%e5%92%8c%ce%b5%e7%9a%84%e9%a6%96%e6%ac%a1%e5%85%a8%e5%90%88%e6%88%90%e5%8f%8a%e5%85%b6%e5%af%b9\/"},"modified":"2018-09-30T09:57:35","modified_gmt":"2018-09-30T01:57:35","slug":"%e3%80%90%e6%9c%89%e6%9c%ba%e3%80%91%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9albomycins-%ce%b41-%ce%b42%e5%92%8c%ce%b5%e7%9a%84%e9%a6%96%e6%ac%a1%e5%85%a8%e5%90%88%e6%88%90%e5%8f%8a%e5%85%b6%e5%af%b9","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/54616\/","title":{"rendered":"\u3010\u6709\u673a\u3011\u5929\u7136\u4ea7\u7269Albomycins \u03b41, \u03b42\u548c\u03b5\u7684\u9996\u6b21\u5168\u5408\u6210\u53ca\u5176\u5bf9\u4e34\u5e8a\u83cc\u682a\u6297\u83cc\u6d3b\u6027\u7814\u7a76"},"content":{"rendered":"
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\u200d\u200d<\/span>\u200d<\/a>\"\u3010\u6709\u673a\u3011\u5929\u7136\u4ea7\u7269Albomycins<\/span><\/a><\/span><\/a><\/p>\n


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\u6297\u751f\u7d20\u7684\u5e7f\u6cdb\u5e94\u7528\uff0c\u7279\u522b\u662f\u6297\u751f\u7d20\u6ee5\u7528\u5bfc\u81f4\u7684\u7ec6\u83cc\u8010\u836f\u6027\u95ee\u9898\u5df2\u6210\u4e3a\u4e34\u5e8a\u6297\u611f\u67d3\u6cbb\u7597\u6700\u4e3a\u68d8\u624b\u7684\u96be\u9898\u4e4b\u4e00\u3002\u591a\u91cd\u8010\u836f\u83cc\u751a\u81f3\u201c\u8d85\u7ea7\u7ec6\u83cc\u201d\u7684\u51fa\u73b0\u53ca\u8513\u5ef6\u5df2\u5bf9\u4eba\u7c7b\u5065\u5eb7\u6784\u6210\u4e86\u65b0\u7684\u5a01\u80c1\u3002\u5f00\u53d1\u65b0\u578b\u7684\u6297\u751f\u7d20\u523b\u4e0d\u5bb9\u7f13\u3002<\/span><\/p>\n


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Albomycins\uff08\u6700\u65e9\u88ab\u79f0\u4e3aGrisein\uff09\u662f\u4ece\u571f\u58e4\u7070\u8272\u94fe\u9709\u83cc\uff08Streptomyces griseus<\/em>\uff09\u7684\u4ee3\u8c22\u7269\u4e2d\u5206\u79bb\u5f97\u5230\u7684\u4e00\u7c7b\u5177\u6709\u663e\u8457\u6297\u83cc\u6d3b\u6027\u7684\u5929\u7136\u4ea7\u7269\uff0c\u5176\u7ed3\u6784\u7531\u94c1\u8f7d\u4f53\uff08Siderophore\uff09\u548c\u786b\u6742\u6838\u82f7\u5316\u5408\u7269\uff08\u5982SB-217452\uff09\u7ec4\u6210\u3002<\/span><\/p>\n

\"\u3010\u6709\u673a\u3011\u5929\u7136\u4ea7\u7269Albomycins<\/p>\n

Albomycins\u7684\u5316\u5b66\u7ed3\u6784\u3002\u56fe\u7247\u6765\u6e90\uff1aNat. Commun.<\/em><\/span><\/p>\n


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\u6700\u8fd1\uff0c\u91cd\u5e86\u5927\u5b66\u836f\u5b66\u9662<\/strong>\u7684\u8d3a\u8018<\/strong>\u6559\u6388\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86<\/span>Albomycin \u03b4<\/span>1<\/sub><\/span>, \u03b4<\/span>2<\/sub><\/span>\u548c\u03b5\u7684\u9996\u6b21\u5168\u5408\u6210<\/span><\/strong>\uff0c\u5e76\u5bf9\u8fd9\u4e09\u4e2a\u5929\u7136\u4ea7\u7269\u8fdb\u884c\u4e86\u6d3b\u6027\u6d4b\u8bd5\uff0c\u5176\u4e2dAlbomycin \u03b4<\/span>2<\/sub><\/span>\u8868\u73b0\u51fa\u4f18\u826f\u7684\u6297\u83cc\u6d3b\u6027\uff0c\u5c24\u5176\u662f\u5bf9\u80ba\u708e\u94fe\u7403\u83cc\u548c\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\uff08\u5305\u62ecMRSA\uff09\u3002\u8fd9\u4e00\u6210\u679c\u5728\u7ebf\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520a<\/span>Nature Communications <\/strong><\/em><\/span>\u4e0a\u3002<\/span><\/p>\n


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\u57fa\u4e8eAlbomycins\u7684\u7ed3\u6784\u7279\u70b9\uff0c\u4f5c\u8005\u91c7\u7528\u6c47\u805a\u5408\u6210\u7684\u65b9\u5f0f\uff0c\u5206\u522b\u5408\u6210\u56db\u80bd\u7247\u6bb52<\/strong>\u548c\u786b\u6742\u6838\u82f73a-c<\/strong>\uff0c\u800c\u7efc\u5408\u8003\u8651\u4fdd\u62a4\u57fa\u7684\u7b5b\u9009\u662f\u987a\u5229\u5b8c\u6210\u5168\u5408\u6210\u7684\u5173\u952e\u3002\u56db\u80bd2<\/strong>\u4ee5\u7b80\u5355\u6613\u5f97\u7684\u9e1f\u6c28\u9178\u5316\u5408\u72698<\/strong>\u4e3a\u8d77\u59cb\u539f\u6599\uff0c\u7ecf\u8fc7\u6c27\u5316\u5f15\u5165\u5f02\u7f9f\u809f\u9178\u90e8\u5206\uff0c\u518d\u901a\u8fc7\u8fde\u7eed\u4e09\u6b65\u7f29\u5408\u53cd\u5e94\uff0c\u5373\u53ef\u4ee5\u8f83\u9ad8\u7684\u6536\u7387\u83b7\u5f97\u3002\u786b\u6742\u6838\u82f73a-c<\/strong>\u7684\u6784\u5efa\u662f\u8be5\u5168\u5408\u6210\u7684\u91cd\u70b9\u4e5f\u662f\u96be\u70b9\u6240\u5728\uff0c\u5c24\u5176\u662f\u9ad8\u6548\u3001\u9ad8\u7acb\u4f53\u9009\u62e9\u6027\u5730\u5f15\u5165\u5c3f\u5627\u5576\u548c\u786b\u6742\u6838\u82f7\u7684\u4fa7\u94fe\u90e8\u5206\u3002\u4f5c\u8005\u6700\u7ec8\u9009\u7528Pummerer\u53cd\u5e94\u5f15\u5165\u5c3f\u5627\u5576\uff0c\u518d\u4ee5Aldol\u53cd\u5e94\u9ad8\u7acb\u4f53\u9009\u62e9\u6027\u5730\u6784\u5efa\u4e86\u786b\u6742\u6838\u82f7\u7684\u4fa7\u94fe\u90e8\u5206\uff0c6\u4e2a\u8fde\u7eed\u7684\u624b\u6027\u4e2d\u5fc3\u901a\u8fc7\u5355\u6676\u884d\u5c04\u786e\u5b9a\u3002\u6700\u540e\uff0c\u4ed6\u4eec\u5206\u522b\u5c06\u56db\u80bd\u7247\u6bb52<\/strong>\u548c\u786b\u6742\u6838\u82f73a-c<\/strong>\u8fdb\u884c\u5076\u8054\uff0c\u5e76\u6d88\u9664\u4fdd\u62a4\u57fa\uff0c\u5f97\u5230\u5929\u7136\u4ea7\u7269Albomycin \u03b4<\/span>1<\/sub><\/span>, \u03b4<\/span>2<\/sub><\/span>\u548c\u03b5\u3002\u7531\u4e8e\u8be5\u7c7b\u5929\u7136\u4ea7\u7269\u6781\u6027\u975e\u5e38\u5927\uff0c\u4f5c\u8005\u9009\u7528\u51dd\u80f6\u67f1Sephadex<\/span>TM<\/sup><\/span> G-15\u5bf9\u6700\u7ec8\u4ea7\u7269\u8fdb\u884c\u5206\u79bb\u7eaf\u5316\u3002<\/span><\/p>\n


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\u7531\u4e8e\u4e4b\u524d\u62a5\u9053\u7684\u6297\u83cc\u6d3b\u6027\u5747\u662f\u4ee5Albomycins\u6df7\u5408\u7269\u7684\u5f62\u5f0f\u8fdb\u884c\u6d4b\u8bd5\uff0c\u4f5c\u8005\u5728\u5b8c\u6210Albomycin \u03b4<\/span>1<\/sub><\/span>, \u03b4<\/span>2<\/sub><\/span>\u548c\u03b5\u7684\u5168\u5408\u6210\u540e\uff0c\u5206\u522b\u5bf9\u4e09\u4e2a\u5929\u7136\u4ea7\u7269\u8fdb\u884c\u4e86\u6d3b\u6027\u6d4b\u8bd5\uff0c\u4ee5\u63a2\u7d22\u5404\u81ea\u7684\u6297\u83cc\u6d3b\u6027\u3002\u4ece\u83b7\u5f97\u7684\u6297\u83cc\u6570\u636e\u53ef\u77e5\uff0cAlbomycin \u03b4<\/span>2<\/sub><\/span>\u7684\u6297\u83cc\u6d3b\u6027\u6700\u4f73\uff0c\u5176\u6297\u83cc\u6d3b\u6027\u4f18\u4e8e\u5bf9\u7167\u836f\u7269Ciprofloxacin\u3001Vancomycin\u548cPenicillin\u3002<\/span><\/p>\n

\"\u3010\u6709\u673a\u3011\u5929\u7136\u4ea7\u7269Albomycins<\/p>\n

Albomycin \u03b4<\/span><\/span>1<\/sub><\/span>, \u03b4<\/span>2<\/sub><\/span>\u548c\u03b5\u7684\u5408\u6210\u8def\u7ebf\u3002\u56fe\u7247\u6765\u6e90\uff1aNat. Commun.<\/em><\/span><\/p>\n


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\"\u3010\u6709\u673a\u3011\u5929\u7136\u4ea7\u7269Albomycins<\/p>\n

Albomycin \u03b4<\/span><\/span>1<\/sub><\/span>, \u03b4<\/span>2<\/sub><\/span>\u548c\u03b5\u6297\u83cc\u6d3b\u6027\u7684\u7b5b\u9009\u3002\u56fe\u7247\u6765\u6e90\uff1aNat. Commun.<\/em><\/span><\/p>\n


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\"\u3010\u6709\u673a\u3011\u5929\u7136\u4ea7\u7269Albomycins<\/p>\n

Albomycin \u03b4<\/span><\/span>2<\/sub><\/span>\u5bf9\u4e34\u5e8a\u80ba\u708e\u94fe\u7403\u83cc\u548c\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\uff08\u5305\u62ecMRSA\uff09\u7684\u6297\u83cc\u6d3b\u6027\u3002\u56fe\u7247\u6765\u6e90\uff1aNat. Commun.<\/em><\/span><\/p>\n


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Albomycin \u03b4<\/span>1<\/sub><\/span>, \u03b4<\/span>2<\/sub><\/span>\u548c\u03b5\u7684\u5168\u5408\u6210\u4ee5\u53ca\u5206\u522b\u8fdb\u884c\u6297\u83cc\u6d3b\u6027\u6d4b\u8bd5\uff0c\u4e3a\u63a5\u4e0b\u6765\u7684\u6784\u6548\u5173\u7cfb\u7814\u7a76\u63d0\u4f9b\u4e86\u575a\u5b9e\u7684\u57fa\u7840\uff0c\u540c\u65f6\u4e5f\u4e3a\u8fdb\u4e00\u6b65\u7684\u4e34\u5e8a\u5f00\u53d1\u505a\u4e86\u5f88\u597d\u7684\u94fa\u57ab\u3002\u91cd\u5e86\u5927\u5b66\u7684\u8d3a\u8018<\/strong>\u6559\u6388\u4e3a\u8be5\u8bba\u6587\u7684\u901a\u8baf\u4f5c\u8005\u3002\u8d3a\u8018\u6559\u6388\u8bfe\u9898\u7ec4\u535a\u58eb\u751f\u6797\u5b50\u534e<\/strong>\u3001\u5f90\u5c0f\u6ce2<\/strong>\u548c\u8d75\u80dc<\/strong>\u4e3a\u5e76\u5217\u7b2c\u4e00\u4f5c\u8005\uff0c\u91cd\u5e86\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u513f\u7ae5\u533b\u9662\u548c\u6e05\u534e\u5927\u5b66\u76d6\u8328\u57fa\u91d1\u5168\u7403\u5065\u5eb7\u836f\u7269\u7814\u53d1\u4e2d\u5fc3\u4e3a\u5408\u4f5c\u5355\u4f4d\u3002<\/span><\/p>\n


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\u8be5\u8bba\u6587\u4f5c\u8005\u4e3a\uff1a<\/span><\/strong>Zihua Lin, Xiaobo Xu, Sheng Zhao, Xiaohong Yang, Jian Guo, Qun Zhang, Chunmei Jing, Shawn Chen & Yun He<\/span><\/p>\n

\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762\uff09\uff1a<\/span><\/p>\n

\"\u3010\u6709\u673a\u3011\u5929\u7136\u4ea7\u7269Albomycins<\/p>\n

Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens<\/span><\/p>\n

Nat. Commun.<\/span><\/em>, 2018<\/strong>, DOI: 10.1038\/s41467-018-05821-1<\/span><\/p>\n


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\u5bfc\u5e08\u4ecb\u7ecd<\/span><\/p>\n

\u8d3a\u8018<\/span><\/p>\n

http:\/\/www.x-mol.com\/university\/faculty\/18606<\/span><\/p>\n

\u8bfe\u9898\u7ec4\u94fe\u63a5<\/span><\/p>\n

http:\/\/www.iddts.com\/<\/span><\/p>\n


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\u6ce8\uff1a<\/span><\/strong>Albomycin\u5c1a\u65e0\u901a\u7528\u7684\u4e2d\u6587\u540d\uff1b\u5df2\u62a5\u9053\u7684\u4e2d\u6587\u540d\u6709\u201c\u767d\u9709\u7d20\u201d\u548c\u201c\u963f\u6ce2\u9709\u7d20\u201d\uff0c\u7ecf\u8fc7\u67e5\u9605\u76f8\u5173\u8d44\u6599\u53d1\u73b0\uff0c\u201c\u767d\u9709\u7d20\u201d\u8fd9\u4e2a\u540d\u5b57\u6307\u5411\u5176\u4ed6\u4e0d\u540c\u7684\u5316\u5408\u7269\u3002\u4f8b\u5982\u767e\u5ea6\u767e\u79d1\u4e2d\uff0c\u201c\u767d\u9709\u7d20\u201d\u7684\u82f1\u6587\u540d\u5b57\u662f\u201cKitasamycin\u201d\uff0c\u800c\u201cKitasamycin\u201d\u4e0e\u201cAlbomycin\u201d\u662f\u4e24\u79cd\u5b8c\u5168\u4e0d\u540c\u7684\u5316\u5408\u7269\u3002\u6240\u4ee5\u4f5c\u8005\u8ba4\u4e3a\u201c\u767d\u9709\u7d20\u201d\u5df2\u4e0d\u5b9c\u7528\u4e8e\u6307\u4ee3\u201cAlbomycin\u201d\uff0c\u800c\u201c\u963f\u6ce2\u9709\u7d20\u201d\u57fa\u672c\u6307\u5411\u201cAlbomycin\u201d\uff0c\u5efa\u8bae\u5728\u5c06\u201cAlbomycin\u201d\u7ffb\u8bd1\u4e3a\u4e2d\u6587\u65f6\uff0c\u7528\u201c\u963f\u6ce2\u9709\u7d20\u201d\u8fd9\u4e00\u540d\u8bcd\uff0c\u7279\u6b64\u8bf4\u660e\u3002<\/span><\/p>\n


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<\/a>\"\u3010\u6709\u673a\u3011\u5929\u7136\u4ea7\u7269Albomycins<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\"\u3010\u6709\u673a\u3011\u5929\u7136\u4ea7\u7269Albomycins<\/p>\n

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\u672c\u6587\u7248\u6743\u5c5e\u4e8eX-MOL<\/strong><\/span>\uff08x-mol.com\uff09\uff0c\u672a\u7ecf\u8bb8\u53ef\u8c22\u7edd\u8f6c\u8f7d\uff01\u6b22\u8fce\u8bfb\u8005\u670b\u53cb\u4eec\u5206\u4eab\u5230\u670b\u53cb\u5708or\u5fae\u535a\uff01<\/span><\/p>\n


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\u957f\u6309<\/strong><\/span>\u4e0b\u56fe\u8bc6\u522b\u56fe\u4e2d\u4e8c\u7ef4\u7801<\/strong>\uff0c\u8f7b\u677e\u5173\u6ce8\u6211\u4eec\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u3010\u6709\u673a\u3011\u5929\u7136\u4ea7\u7269Albomycins<\/p>\n<\/section>\n<\/section>\n

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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587<\/span>\u201d\uff0c\u67e5\u770b \u5316\u5b66 \u2022 \u6750\u6599 <\/strong>\u9886\u57df\u6240\u6709\u6536\u5f55\u671f\u520a<\/span><\/span><\/p>\n

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