{"id":54760,"date":"2018-09-27T01:00:00","date_gmt":"2018-09-30T01:58:35","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/uiuc%e9%99%86%e8%89%ba%e5%9b%a2%e9%98%9fscience%ef%bc%9a%e4%ba%ba%e5%b7%a5%e5%90%88%e6%88%90%e9%87%91%e5%b1%9e%e9%85%b6%e5%82%ac%e5%8c%96%e8%bf%98%e5%8e%9f%e4%ba%9a%e7%a1%ab%e9%85%b8%e7%9b%90\/"},"modified":"2018-09-30T09:58:38","modified_gmt":"2018-09-30T01:58:38","slug":"uiuc%e9%99%86%e8%89%ba%e5%9b%a2%e9%98%9fscience%ef%bc%9a%e4%ba%ba%e5%b7%a5%e5%90%88%e6%88%90%e9%87%91%e5%b1%9e%e9%85%b6%e5%82%ac%e5%8c%96%e8%bf%98%e5%8e%9f%e4%ba%9a%e7%a1%ab%e9%85%b8%e7%9b%90","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/54760\/","title":{"rendered":"UIUC\u9646\u827a\u56e2\u961fScience\uff1a\u4eba\u5de5\u5408\u6210\u91d1\u5c5e\u9176\u50ac\u5316\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u2014\u2014\u91d1\u5c5e\u86cb\u767d\u5de5\u7a0b\u7528\u4e8e\u50ac\u5316\u5242\u8bbe\u8ba1\u7684\u91cc\u7a0b\u7891"},"content":{"rendered":"
\n

\u200d\u200d<\/span>\u200d<\/a>\"UIUC\u9646\u827a\u56e2\u961fScience\uff1a\u4eba\u5de5\u5408\u6210\u91d1\u5c5e\u9176\u50ac\u5316\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u2014\u2014\u91d1\u5c5e\u86cb\u767d\u5de5\u7a0b\u7528\u4e8e\u50ac\u5316\u5242\u8bbe\u8ba1\u7684\u91cc\u7a0b\u7891\"<\/span><\/a><\/span><\/a><\/p>\n


<\/a><\/p>\n

\u65e0\u673a\u6c27\u5316\u6001\u9634\u79bb\u5b50\u5982\u9ad8\u6c2f\u9178\u76d0\u3001\u785d\u9178\u76d0\u3001\u7837\u9178\u76d0\u662f\u73af\u5883\u4e2d\u7684\u6c34\u6eb6\u6027\u6c61\u67d3\u7269\uff0c\u5b83\u4eec\u5bb9\u6613\u5728\u6c34\u57df\u4e2d\u6269\u6563\uff0c\u5bfc\u81f4\u591a\u79cd\u5065\u5eb7\u6216\u73af\u5883\u95ee\u9898\u3002\u73b0\u6709\u9664\u53bb\u8fd9\u4e9b\u6c27\u5316\u6001\u9634\u79bb\u5b50\u7684\u65b9\u6cd5\u4e3b\u8981\u662f\u5c06\u5355\u4e00\u7684\u6c27\u5316\u6001\u9634\u79bb\u5b50\u5bcc\u96c6\u4e8e\u542b\u91d1\u5c5e\u7684\u6709\u673a\u7269\u4e2d\uff0c\u6216\u7528\u8fc7\u6e21\u91d1\u5c5e\u5143\u7d20\u50ac\u5316\u8fd8\u539f\u3002\u7136\u800c\u8fd9\u4e9b\u6c27\u5316\u6001\u9634\u79bb\u5b50\u6c61\u67d3\u7269\u4e0e\u8fc7\u6e21\u91d1\u5c5e\u7684\u7ed3\u5408\u80fd\u529b\u5f31\uff0c\u800c\u4e14\u73af\u5883\u4e2d\u5176\u4ed6\u7684\u6c27\u5316\u6001\u79bb\u5b50\uff08\u5982\u4e9a\u786b\u9178\u76d0\uff09\u4f1a\u5e72\u6270\u8fd9\u4e9b\u6709\u5bb3\u6c27\u5316\u6001\u9634\u79bb\u5b50\u7684\u751f\u7269\u964d\u89e3\u8fc7\u7a0b\uff0c\u5bfc\u81f4\u6c27\u5316\u6001\u9634\u79bb\u5b50\u6c61\u67d3\u7269\u96be\u4ee5\u88ab\u6709\u6548\u6e05\u9664\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u53bb\u9664\u73af\u5883\u4e2d\u7684\u6c27\u5316\u6001\u9634\u79bb\u5b50\u6c61\u67d3\u4e00\u76f4\u662f\u5316\u5b66\u5bb6\u9762\u4e34\u7684\u91cd\u8981\u6311\u6218\u3002<\/span><\/p>\n


<\/p>\n

\u7531\u4e8e\u53cd\u5e94\u6b65\u9aa4\u591a\u3001\u50ac\u5316\u6d3b\u6027\u4f4d\u70b9\u590d\u6742\u7b49\u539f\u56e0\uff0c\u8bbe\u8ba1\u4eba\u5de5\u50ac\u5316\u5242\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u7684\u53cd\u5e94\u5728\u6b64\u4e4b\u524d\u4e00\u76f4\u6ca1\u80fd\u88ab\u79d1\u5b66\u5bb6\u5b9e\u73b0\u3002\u8fd9\u4e9b\u6c27\u5316\u6001\u79bb\u5b50\u7684\u8fd8\u539f\u53ea\u80fd\u901a\u8fc7\u5fae\u751f\u7269\u819c\u7684\u65e0\u6c27\u547c\u5438\u8fc7\u7a0b\u5b8c\u6210\uff0c\u8be5\u8fc7\u7a0b\u4e2d\u50ac\u5316\u8fd9\u4e00\u751f\u7269\u8fd8\u539f\u53cd\u5e94\u7684\u662f\u4e9a\u786b\u9178\u76d0\u8fd8\u539f\u9176<\/strong>\uff08sulfite reductase, SiR\uff09\uff0c\u8fd9\u79cd\u9176\u5305\u542b\u4e00\u4e2a\u539f\u8840\u7ea2\u7d20<\/strong>\uff08Siroheme\uff09\u548c\u4e00\u4e2a\u7acb\u65b9\u70f7\u578b\u56db\u94c1\u56db\u786b\u7c07\u5408\u7269<\/strong>\uff08[4Fe-4S]\uff09\u3002\u4e9a\u786b\u9178\u76d0\u8fd8\u539f\u9176\u4e2d\u7684\u4e00\u4e2a\u534a\u80f1\u6c28\u9178\u6b8b\u57fa\u540c\u65f6\u5145\u5f53\u539f\u8840\u7ea2\u7d20\u548c\u94c1\u786b\u7c07\u57fa\u56e2\u4e2d\u4e00\u4e2a\u94c1\u539f\u5b50\u7684\u914d\u4f53\uff0c\u5e2e\u52a9\u7535\u5b50\u4ece\u94c1\u786b\u7c07\u8f6c\u79fb\u5230\u539f\u8840\u7ea2\u7d20\uff0c\u8fdb\u884c\u4e9a\u786b\u9178\u76d0\u7684\u8fd8\u539f\u53cd\u5e94\uff08\u56fe1\uff09\u3002\u636e\u6b64\u539f\u7406\uff0c\u6b64\u524d\u79d1\u5b66\u5bb6\u4eec\u8bd5\u56fe\u7528\u540c\u65f6\u5305\u542b\u94c1\u786b\u7c07\u548c\u8840\u7ea2\u7d20\uff08heme\uff09\u7684\u4eba\u5de5\u5408\u6210\u86cb\u767d\u7ed3\u6784\u6765\u6a21\u62df\u4e9a\u786b\u9178\u76d0\u8fd8\u539f\u9176\uff0c\u7136\u800c\u8fd9\u4e9b\u5408\u6210\u7cfb\u7edf\u6ca1\u6709\u5e2e\u52a9\u7535\u5b50\u4f20\u9012\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\uff0c\u5e76\u4e0d\u5177\u5907\u50ac\u5316\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u7684\u80fd\u529b\u3002<\/span><\/p>\n

\"UIUC\u9646\u827a\u56e2\u961fScience\uff1a\u4eba\u5de5\u5408\u6210\u91d1\u5c5e\u9176\u50ac\u5316\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u2014\u2014\u91d1\u5c5e\u86cb\u767d\u5de5\u7a0b\u7528\u4e8e\u50ac\u5316\u5242\u8bbe\u8ba1\u7684\u91cc\u7a0b\u7891\"<\/p>\n

\u56fe1. \u6a21\u62dfSiR\u9176\u8bbe\u8ba1\u7ec6\u80de\u8272\u7d20C\u8fc7\u6c27\u5316\u7269\u9176\u7ed3\u5408\u94c1\u786b\u7c07\u4f4d\u70b9\u3002\u56fe\u7247\u6765\u6e90\uff1a<\/span>Science<\/em>
<\/span><\/p>\n


<\/p>\n

\u7f8e\u56fd\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66\u9999\u69df\u5206\u6821<\/span><\/strong>\uff08UIUC\uff09\u7684\u9646\u827a<\/strong>\uff08Yi Lu\uff09\u6559\u6388\u8bfe\u9898\u7ec4\u957f\u671f\u4ee5\u6765\u5173\u6ce8\u4e8e\u751f\u7269\u5408\u6210\u5316\u5b66\u7814\u7a76\u4ee5\u53ca\u5e94\u7528\u3002\u8be5\u8bfe\u9898\u7ec4\u4f7f\u7528\u751f\u7269\u5de5\u7a0b\u53ca\u5408\u6210\u751f\u7269\u5b66\u65b9\u6cd5\u5408\u6210\u91d1\u5c5e\u86cb\u767d\u7684\u6a21\u62df\u7269\u4f5c\u4e3a\u751f\u7269\u50ac\u5316\u5242\uff0c\u5e76\u4e14\u7814\u7a76\u91d1\u5c5e\u86cb\u767d\u53ca\u751f\u7269\u50ac\u5316\u5242\u7684\u7ed3\u6784\u4e0e\u529f\u80fd\u3002\u6b64\u5916\uff0c\u8be5\u8bfe\u9898\u7ec4\u540c\u65f6\u5173\u6ce8\u751f\u7269\u50ac\u5316\u5242\u7684\u5c0f\u5206\u5b50\u6fc0\u6d3b\u65b9\u5f0f\u53ca\u5728\u518d\u751f\u80fd\u6e90\u4e2d\u7684\u5e94\u7528\u3002\u6700\u8fd1\uff0c\u8be5\u8bfe\u9898\u7ec4\u901a\u8fc7\u5c06\u94c1\u786b\u7c07\u57fa\u56e2\u5f15\u5165\u7ec6\u80de\u8272\u7d20C\u8fc7\u6c27\u5316\u7269\u9176<\/strong>\uff08cytochrome c<\/em> peroxidase, CcP\uff09\uff0c\u6539\u9020\u91d1\u5c5e\u548c\u5e95\u7269\u7ed3\u5408\u4f4d\u70b9\u7684\u4e8c\u7ea7\u914d\u4f4d\u533a\u57df\u6c28\u57fa\u9178\uff0c\u8bbe\u8ba1\u548c\u5408\u6210\u4e86\u53ef\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u7684\u4eba\u5de5\u5408\u6210\u91d1\u5c5e\u9176<\/strong>\uff0c\u7a81\u7834\u4e86\u751f\u7269\u50ac\u5316\u9886\u57df\u591a\u5e74\u7684\u6280\u672f\u74f6\u9888\u3002\u76f8\u5173\u8bba\u6587\u8fd1\u671f\u53d1\u8868\u5728Science <\/em><\/strong>\u4e0a\uff0c\u540c\u671fScience <\/em>\u6742\u5fd7\u8fd8\u520a\u767b\u4e86\u5eb7\u5948\u5c14\u5927\u5b66Kyle M. Lancaster\u6559\u6388\u5bf9\u6b64\u9879\u5de5\u4f5c\u9898\u4e3a\u201cRevving up an artificial metalloenzyme\u201d\u7684\u8bc4\u8bba\u6587\u7ae0\uff0c\u79f0\u8fd9\u4e00\u6210\u679c\u4e3a\u201c\u4f7f\u7528\u91d1\u5c5e\u86cb\u767d\u5de5\u7a0b\u4f5c\u4e3a\u50ac\u5316\u5242\u8bbe\u8ba1\u5de5\u5177\u7684\u4e00\u4e2a\u91cc\u7a0b\u7891<\/strong>\u201d <\/span><\/sup><\/span>[1]<\/span><\/sup><\/span>\u3002<\/span><\/p>\n

\"UIUC\u9646\u827a\u56e2\u961fScience\uff1a\u4eba\u5de5\u5408\u6210\u91d1\u5c5e\u9176\u50ac\u5316\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u2014\u2014\u91d1\u5c5e\u86cb\u767d\u5de5\u7a0b\u7528\u4e8e\u50ac\u5316\u5242\u8bbe\u8ba1\u7684\u91cc\u7a0b\u7891\"<\/p>\n

\u9646\u827a\u6559\u6388\u3002\u56fe\u7247\u6765\u6e90\uff1a\u9646\u827a\u6559\u6388\u8bfe\u9898\u7ec4 \/ UIUC<\/span>
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\u7ec6\u80de\u8272\u7d20C\u8fc7\u6c27\u5316\u7269\u9176\u662f\u4e00\u4e2a\u5929\u7136\u7684\u8840\u7ea2\u7d20\u7ed3\u5408\u86cb\u767d\uff0c\u5177\u6709\u4f53\u79ef\u5c0f\u3001\u7a33\u5b9a\u6027\u597d\u7684\u4f18\u52bf\u3002\u4f5c\u8005\u5229\u7528\u86cb\u767d\u8bbe\u8ba1\u8f6f\u4ef6\uff0c\u7ed3\u5408\u8ba1\u7b97\u5206\u6790\u65b9\u6cd5\u548c\u5408\u7406\u8bbe\u8ba1\u539f\u7406\uff0c\u7b5b\u9009\u9488\u5bf9\u7ec6\u80de\u8272\u7d20C\u8fc7\u6c27\u5316\u7269\u9176\u86cb\u767d\u9aa8\u67b6\u7684\u5b9a\u70b9\u7a81\u53d8\uff0c\u5c06\u94c1\u786b\u7c07[4Fe-4S]\u91cd\u7ec4\u5230\u8840\u7ea2\u7d20\u8fd1\u7aef\u7684\u7a7a\u8154\u4e2d\u3002\u4ed6\u4eec\u9009\u62e9\u5c06\u7b2c175\u4f4d\u7684\u7ec4\u6c28\u9178\u7a81\u53d8\u4e3a\u534a\u80f1\u6c28\u9178\uff0c\u5145\u5f53\u8fde\u63a5\u8840\u7ea2\u7d20\u548c\u94c1\u786b\u7c07\u7684\u914d\u4f53\uff1b\u5c06\u7b2c180\u4f4d\u7684\u82cf\u6c28\u9178\u3001\u7b2c191\u4f4d\u7684\u8272\u6c28\u9178\u548c\u7b2c232\u4f4d\u7684\u4eae\u6c28\u9178\u5206\u522b\u7a81\u53d8\u4e3a\u4e09\u4e2a\u534a\u80f1\u6c28\u9178\uff0c\u8f85\u52a9\u94c1\u786b\u7c07\u4e2d\u94c1\u539f\u5b50\uff1b\u540c\u65f6\u5c06\u7b2c230\u4f4d\u7684\u7532\u786b\u6c28\u9178\u7a81\u53d8\u4e3a\u4e19\u6c28\u9178\u3001\u7b2c235\u4f4d\u5929\u51ac\u6c28\u9178\u7a81\u53d8\u4e3a\u7f2c\u6c28\u9178\u4ee5\u589e\u5f3a\u86cb\u767d\u7a33\u5b9a\u6027\uff08\u56fe1\uff09\u3002\u57fa\u4e8e\u8fd9\u4e9b\u8bbe\u8ba1\uff0c\u4f5c\u8005\u4eba\u5de5\u5408\u6210\u4e86\u57fa\u4e8e\u7ec6\u80de\u8272\u7d20C\u8fc7\u6c27\u5316\u7269\u9176\u86cb\u767d\u9aa8\u67b6\u7684\u5408\u6210\u86cb\u767d\u6765\u6a21\u62df\u5929\u7136\u4e9a\u786b\u9178\u76d0\u8fd8\u539f\u9176\u3002<\/span><\/p>\n


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\u901a\u8fc7\u4e00\u7cfb\u5217\u7684\u7d2b\u5916-\u53ef\u89c1\u5438\u6536\u3001\u7535\u5b50\u987a\u78c1\u5171\u632f\u3001\u6269\u5c55X-\u5c04\u7ebf\u5438\u6536\u7cbe\u7ec6\u7ed3\u6784\u7b49\u5149\u8c31\u8868\u5f81\u624b\u6bb5\uff0c\u4f5c\u8005\u8bc1\u660e\u4e86\u7ec6\u80de\u8272\u7d20C\u8fc7\u6c27\u5316\u7269\u9176\u86cb\u767d\u9aa8\u67b6\u7684\u8868\u8fbe\u7eaf\u5316\u4ee5\u53ca\u94c1\u786b\u7c07\u548c\u8840\u7ea2\u7d20\u7684\u6210\u529f\u6574\u5408\uff08\u56fe2a-c\uff09\u3002\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5206\u522b\u6d4b\u8bd5\u6bd4\u8f83\u4e86\u5408\u6210\u86cb\u767d\u3001\u5929\u7136\u4e9a\u786b\u9178\u76d0\u8fd8\u539f\u9176\u548c\u7ec6\u80de\u8272\u7d20C\u8fc7\u6c27\u5316\u7269\u9176\u4e0e\u6c30\u6839\u79bb\u5b50\u7684\u7ed3\u5408\u80fd\u529b\uff08\u56fe2c-d\uff09\uff0c\u5e76\u901a\u8fc7\u6bd4\u8f83\u8fd9\u4e09\u4e2a\u86cb\u767d\u5b58\u5728\u65f6\u4e9a\u786b\u9178\u94a0\u5bf9\u7535\u5b50\u4f20\u9012\u4ecb\u8d28\u7532\u57fa\u7d2b\u7cbe\u7684\u6c27\u5316\u80fd\u529b\uff0c\u8bc1\u5b9e\u4eba\u5de5\u5408\u6210\u86cb\u767d\u83b7\u5f97\u4e86\u50ac\u5316\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u7684\u80fd\u529b\u3002<\/span><\/p>\n

\"UIUC\u9646\u827a\u56e2\u961fScience\uff1a\u4eba\u5de5\u5408\u6210\u91d1\u5c5e\u9176\u50ac\u5316\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u2014\u2014\u91d1\u5c5e\u86cb\u767d\u5de5\u7a0b\u7528\u4e8e\u50ac\u5316\u5242\u8bbe\u8ba1\u7684\u91cc\u7a0b\u7891\"<\/p>\n

\u56fe2. \u4eba\u5de5\u5408\u6210\u86cb\u767d\u7ed3\u5408\u8840\u7ea2\u7d20\u53ca\u94c1\u786b\u7c07\u540e\u7684\u5149\u8c31\u6027\u8d28\u3002\u56fe\u7247\u6765\u6e90\uff1a<\/span>Science<\/em>
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\u4e3a\u8fdb\u4e00\u6b65\u63d0\u5347\u5408\u6210\u86cb\u767d\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u7684\u50ac\u5316\u80fd\u529b\uff0c\u4f5c\u8005\u7cfb\u7edf\u5206\u6790\u4e86\u5929\u7136\u4e9a\u786b\u9178\u76d0\u8fd8\u539f\u9176\u7684\u6d3b\u6027\u533a\u57df\uff0c\u5e76\u5bf9\u5408\u6210\u86cb\u767d\u8fdb\u884c\u6539\u9020\uff0c\u5c06\u7b2c51\u4f4d\u8272\u6c28\u9178\u7a81\u53d8\u4e3a\u8d56\u6c28\u9178\u3001\u7b2c52\u4f4d\u7ec4\u6c28\u9178\u7a81\u53d8\u4e3a\u7cbe\u6c28\u9178\u3001\u7b2c145\u4f4d\u812f\u6c28\u9178\u7a81\u53d8\u4e3a\u8d56\u6c28\u9178\uff0c\u63d0\u5347\u86cb\u767d\u7684\u5e95\u7269\u7ed3\u5408\u80fd\u529b\u548c\u8d28\u5b50\u5316\u80fd\u529b\uff0c\u6210\u529f\u5c06\u5408\u6210\u86cb\u767d\u7684\u50ac\u5316\u6d3b\u6027\u63d0\u9ad85.3\u500d\uff08\u56fe3a\uff09\u3002\u4e4b\u540e\u4f5c\u8005\u8fdb\u4e00\u6b65\u5bf9\u5408\u6210\u86cb\u767d\u4e2d\u4e0e\u94c1\u786b\u7c07\u53ca\u8840\u7ea2\u7d20\u76f8\u4e92\u4f5c\u7528\u7684\u4e8c\u7ea7\u914d\u4f4d\u533a\u57df<\/span>\u6c28\u57fa\u9178\u8fdb\u884c\u4f18\u5316\uff0c\u5c06\u7b2c235\u4f4d\u5929\u51ac\u6c28\u9178\u7a81\u53d8\u4e3a\u534a\u80f1\u6c28\u9178\uff08\u56fe3b\uff09\uff0c\u589e\u52a0\u4e8c\u7ea7\u914d\u4f4d\u533a\u57df\u4e0e\u94c1\u786b\u7c07\u57fa\u56e2\u7684\u6c22\u952e\u7ed3\u5408\uff0c\u4f7f\u5408\u6210\u9176\u6d3b\u6027\u8f83\u6700\u521d\u7248\u672c\u63d0\u9ad863\u500d\u3002\u7ecf\u8fc7\u8fde\u7eed\u7684\u6539\u9020\uff0c\u5408\u6210\u86cb\u767d\u7684\u6d3b\u6027\u8fbe\u5230\u5929\u7136\u4e9a\u786b\u9178\u76d0\u8fd8\u539f\u9176\u7684\u8fd120%\uff08\u56fe3c\uff09\uff0c\u80fd\u5c06\u4e9a\u786b\u9178\u76d0\u8fd8\u539f\u4e3a\u786b\u5316\u6c22\uff08\u516d\u7535\u5b50\u8fd8\u539f\u4ea7\u7269\uff09\u4ee5\u53ca\u4e24\u7535\u5b50\u548c\u56db\u7535\u5b50\u8fd8\u539f\u7684\u4e2d\u95f4\u4ea7\u7269\u3002\u603b\u4f53\u7535\u5b50\u5229\u7528\u7387\u9ad8\u8fbe90%\uff0c\u5e95\u7269\u8f6c\u5316\u6548\u7387\u63a5\u8fd1\u5f02\u5316\u578b\u7684\u5929\u7136\u4e9a\u786b\u9178\u76d0\u8fd8\u539f\u9176\u3002\u6574\u4e2a\u5408\u6210\u86cb\u767d\u7684\u6539\u9020\u8fc7\u7a0b\u63ed\u793a\u4e86\u4e8c\u7ea7\u914d\u4f4d\u533a\u57df\u6c28\u57fa\u9178\u5bf9\u591a\u7535\u5b50\u8f6c\u79fb\u7684\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u9176\u6d3b\u6027\u5177\u6709\u91cd\u8981\u4f5c\u7528<\/strong>\uff0c\u4e3a\u5176\u4ed6\u5229\u7528\u7b80\u5355\u86cb\u767d\u9aa8\u67b6\u5b9e\u73b0\u591a\u7535\u5b50\u3001\u591a\u8d28\u5b50\u8f6c\u79fb\u53cd\u5e94\u7684\u86cb\u767d\u5de5\u7a0b\u5b66\u7814\u7a76\u63d0\u4f9b\u542f\u53d1\u548c\u501f\u9274\u3002<\/span><\/p>\n

\"UIUC\u9646\u827a\u56e2\u961fScience\uff1a\u4eba\u5de5\u5408\u6210\u91d1\u5c5e\u9176\u50ac\u5316\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u2014\u2014\u91d1\u5c5e\u86cb\u767d\u5de5\u7a0b\u7528\u4e8e\u50ac\u5316\u5242\u8bbe\u8ba1\u7684\u91cc\u7a0b\u7891\"<\/p>\n

\u56fe3. \u7ed3\u5408\u94c1\u786b\u7c07\u7684\u4e8c\u7ea7\u914d\u4f4d\u533a\u57df\u6c28\u57fa\u9178\u6b8b\u57fa\u7a81\u53d8\u51b3\u5b9a\u4eba\u5de5\u5408\u6210\u86cb\u767d\u50ac\u5316\u6d3b\u6027\u3002\u56fe\u7247\u6765\u6e90\uff1a<\/span>Science<\/em>
<\/span><\/p>\n


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\u2014\u2014\u603b\u7ed3\u2014\u2014<\/span><\/strong><\/p>\n


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\u4f5c\u4e3a\u73af\u5883\u7684\u4e3b\u8981\u6c61\u67d3\u7269\uff0c\u4e0d\u540c\u6c27\u5316\u6001\u7684\u9178\u6839\u79bb\u5b50\u5982\u4f55\u6e05\u9664\u964d\u89e3\u4e00\u76f4\u662f\u56f0\u6270\u5316\u5b66\u5bb6\u548c<\/span>\u751f\u7269\u5316\u5b66\u5bb6\u7684\u74f6\u9888\u95ee\u9898\u3002\u5982\u4eca\uff0c\u9646\u827a\u6559\u6388\u8bfe\u9898\u7ec4\u901a\u8fc7\u6a21\u62df\u751f\u7269\u4f53\u4e2d\u7684\u4e9a\u786b\u9178\u76d0\u8fd8\u539f\u9176\uff0c\u57fa\u4e8e\u7b80\u5355\u7684\u86cb\u767d\u9aa8\u67b6\uff0c\u9488\u5bf9\u6027\u5730\u8bbe\u8ba1\u5e76\u6210\u529f\u5408\u6210\u80fd\u50ac\u5316\u591a\u7535\u5b50\u8f6c\u79fb\u53cd\u5e94\u7684\u9ad8\u6548\u7387\u65b0\u578b\u50ac\u5316\u5242\uff0c\u4e3a\u8bbe\u8ba1\u66f4\u591a\u7684\u9176\u7c7b\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\uff0c\u4e5f\u5728\u73af\u5883\u6c61\u67d3\u6cbb\u7406\u7b49\u76f8\u5173\u9886\u57df\u6709\u91cd\u8981\u610f\u4e49\u3002\u8be5\u7814\u7a76\u4e3b\u8981\u5f97\u5230\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u548c\u7f8e\u56fd\u80fd\u6e90\u90e8\u7684\u91cd\u8981\u8d44\u52a9\u3002\u9646\u827a\u6559\u6388\u8bfe\u9898\u7ec4\u5728\u8be5\u7814\u7a76\u53ca\u76f8\u5173\u7814\u7a76\u4e2d\u83b7\u5f97\u591a\u9879\u56fd\u9645\u4e13\u5229\uff0c\u5e76\u79ef\u6781\u63a8\u52a8\u79d1\u7814\u6210\u679c\u7684\u5e02\u573a\u8f6c\u5316\u3002<\/span><\/p>\n


<\/p>\n

\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762\uff09\uff1a<\/span><\/p>\n

\"UIUC\u9646\u827a\u56e2\u961fScience\uff1a\u4eba\u5de5\u5408\u6210\u91d1\u5c5e\u9176\u50ac\u5316\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u2014\u2014\u91d1\u5c5e\u86cb\u767d\u5de5\u7a0b\u7528\u4e8e\u50ac\u5316\u5242\u8bbe\u8ba1\u7684\u91cc\u7a0b\u7891\"<\/p>\n

A designed heme-[4Fe-4S] metalloenzyme catalyzes sulfite reduction like the native enzyme<\/span><\/p>\n

Science<\/span><\/em>, 2018<\/strong>, 361<\/em>, 1098-1101, DOI: 10.1126\/science.aat8474<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

1. Revving up an artificial metalloenzyme. Science<\/em>, 2018<\/strong>, 361<\/em>, 1071-1072, DOI: 10.1126\/science.aau7754<\/span><\/p>\n


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\u7814\u7a76\u56e2\u961f\u7b80\u4ecb<\/span><\/strong><\/p>\n


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\u9646\u827a\u6559\u6388\u73b0\u4e3a\u7f8e\u56fd\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66\u9999\u69df\u5206\u6821\u5316\u5b66\u7cfb\u3001\u751f\u7269\u5316\u5b66\u7cfb\u3001\u6750\u6599\u79d1\u5b66\u53ca\u5de5\u7a0b\u7cfb\u3001\u751f\u7269\u5de5\u7a0b\u7cfb\u7ec8\u8eab\u6559\u6388\uff0cHHMI\u6559\u6388\uff0c\u5e76\u5728\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66Beckman\u7814\u7a76\u6240\u3001\u751f\u7269\u7269\u7406\u53ca\u5b9a\u91cf\u751f\u7269\u5b66\u7814\u7a76\u6240\u3001\u751f\u7269\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76\u6240\u751f\u7269\u7cfb\u7edf\u8bbe\u8ba1\u65b9\u5411\u3001\u7eb3\u7c73\u6280\u672f\u53ca\u7cbe\u51c6\u836f\u7269\u65b9\u5411\u4efb\u804c\u3002\u4ed6\u7684\u7814\u7a76\u9886\u57df\u96c6\u4e2d\u5728\u751f\u7269\u5408\u6210\u5316\u5b66\u53ca\u50ac\u5316\u86cb\u767d\u7684\u673a\u5236\u4ee5\u53ca\u5e94\u7528\uff0c\u5305\u62ec\u91d1\u5c5e\u86cb\u767d\u50ac\u5316\u5242\u6a21\u62df\u3001\u4fe1\u606f\u5316\u9884\u6d4b\u86cb\u767d\u6d3b\u6027\u3001\u591a\u79cd\u86cb\u767d\u8d28\u7684\u6c27\u5316\u8fd8\u539f\u7535\u52bf\u8c03\u8282\u3001\u7535\u5b50\u4f20\u9012\u86cb\u767d\u6539\u9020\u3001\u6c2e\u6c27\u5316\u7269\u8fd8\u539f\u9176\u5e94\u7528\u7b49\u3002\u4ed6\u7684\u7814\u7a76\u5de5\u4f5c\u5f97\u5230\u4e86\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u3001\u7f8e\u56fd\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u80fd\u6e90\u90e8\u8d44\u52a9\uff0c\u5728<\/span>Nature\u3001Science\u3001JACS\u3001PNAS\u3001Nature Chemistry\u3001Nature Nanotechnology<\/em><\/span> <\/em>\u7b49\u671f\u520a\u53d1\u8868\u8bba\u6587330\u4f59\u7bc7\uff0c\u83b7\u5f97\u4e13\u522930\u4e2a\uff0c\u8bba\u6587\u5f15\u7528\u8d85\u8fc720,000\u6b21\u3002\u4ed6\u83b7\u5f97\u591a\u9879\u79d1\u7814\u53ca\u6559\u5b66\u5956\u9879\uff0c\u5305\u62ec\u82f1\u56fd\u7687\u5bb6\u5316\u5b66\u5b66\u4f1a\u5e94\u7528\u65e0\u673a\u5316\u5b66\u5956\u3001\u82f1\u56fd\u7687\u5bb6\u5316\u5b66\u4f1a\u4f1a\u5458\u3001\u7f8e\u56fd\u79d1\u5b66\u4fc3\u8fdb\u534f\u4f1a\u4f1a\u5458\u3001Jay and Ann Schenck\u6559\u6388\u3001\u4f18\u79c0\u6559\u5b66\u5956\u7b49\u3002\u4ece2015\u52302018\u5e74\uff0c\u9646\u6559\u6388\u8fde\u7eed\u56db\u5e74\u88ab\u6c64\u68ee\u8def\u900f\u5217\u5165\u201c\u9ad8\u88ab\u5f15\u7528\u79d1\u5b66\u5bb6\u201d\u540d\u5355\u3002<\/span><\/p>\n


<\/p>\n

\u9646\u827a\u6559\u6388<\/span><\/p>\n

https:\/\/chemistry.illinois.edu\/yi-lu<\/span><\/p>\n

http:\/\/www.x-mol.com\/university\/faculty\/188<\/span><\/p>\n

\u8bfe\u9898\u7ec4\u4e3b\u9875<\/span>
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http:\/\/lulab.scs.illinois.edu\/<\/span><\/p>\n


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\"UIUC\u9646\u827a\u56e2\u961fScience\uff1a\u4eba\u5de5\u5408\u6210\u91d1\u5c5e\u9176\u50ac\u5316\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u2014\u2014\u91d1\u5c5e\u86cb\u767d\u5de5\u7a0b\u7528\u4e8e\u50ac\u5316\u5242\u8bbe\u8ba1\u7684\u91cc\u7a0b\u7891\"<\/p>\n

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\u672c\u6587\u7248\u6743\u5c5e\u4e8eX-MOL<\/strong><\/span>\uff08x-mol.com\uff09\uff0c\u672a\u7ecf\u8bb8\u53ef\u8c22\u7edd\u8f6c\u8f7d\uff01\u6b22\u8fce\u8bfb\u8005\u670b\u53cb\u4eec\u5206\u4eab\u5230\u670b\u53cb\u5708or\u5fae\u535a\uff01<\/span><\/p>\n


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\u957f\u6309<\/strong><\/span>\u4e0b\u56fe\u8bc6\u522b\u56fe\u4e2d\u4e8c\u7ef4\u7801<\/strong>\uff0c\u8f7b\u677e\u5173\u6ce8\u6211\u4eec\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"UIUC\u9646\u827a\u56e2\u961fScience\uff1a\u4eba\u5de5\u5408\u6210\u91d1\u5c5e\u9176\u50ac\u5316\u8fd8\u539f\u4e9a\u786b\u9178\u76d0\u2014\u2014\u91d1\u5c5e\u86cb\u767d\u5de5\u7a0b\u7528\u4e8e\u50ac\u5316\u5242\u8bbe\u8ba1\u7684\u91cc\u7a0b\u7891\"<\/p>\n<\/section>\n<\/section>\n

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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587<\/span>\u201d\uff0c\u67e5\u770b \u5316\u5b66 \u2022 \u6750\u6599 <\/strong>\u9886\u57df\u6240\u6709\u6536\u5f55\u671f\u520a<\/span><\/span><\/p>\n

<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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