{"id":54952,"date":"2018-09-29T01:00:00","date_gmt":"2018-09-30T02:00:05","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e9%80%9f%e9%80%92-%e6%98%be%e8%91%97%e5%87%8f%e5%b0%91%e5%a4%b4%e7%97%9b%e5%8f%91%e4%bd%9c%e5%a4%a9%e6%95%b0%ef%bc%8c%e7%a4%bc%e6%9d%a5%e5%85%ac%e5%8f%b8%e5%81%8f%e5%a4%b4%e7%97%9b%e6%96%b0\/"},"modified":"2018-09-30T10:00:07","modified_gmt":"2018-09-30T02:00:07","slug":"%e9%80%9f%e9%80%92-%e6%98%be%e8%91%97%e5%87%8f%e5%b0%91%e5%a4%b4%e7%97%9b%e5%8f%91%e4%bd%9c%e5%a4%a9%e6%95%b0%ef%bc%8c%e7%a4%bc%e6%9d%a5%e5%85%ac%e5%8f%b8%e5%81%8f%e5%a4%b4%e7%97%9b%e6%96%b0","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/54952\/","title":{"rendered":"\u901f\u9012 | \u663e\u8457\u51cf\u5c11\u5934\u75db\u53d1\u4f5c\u5929\u6570\uff0c\u793c\u6765\u516c\u53f8\u504f\u5934\u75db\u65b0\u836f\u83b7\u6279"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/p>\n


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\u8fd1\u65e5\uff0c\u793c\u6765\u516c\u53f8\uff08Eli Lilly\uff09\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u6279\u51c6\u8be5\u516c\u53f8\u7684Emgality\uff08galcanezumab-gnlm\uff09120 mg\u6ce8\u5c04\u5242\u4f5c\u4e3a\u6210\u4eba\u504f\u5934\u75db\uff08migraine\uff09\u7684\u9884\u9632\u7597\u6cd5\u3002<\/strong>Emgality\u662f\u6bcf\u6708\u4e00\u6b21\uff0c\u53ef\u4ee5\u7531\u60a3\u8005\u81ea\u6211\u6ce8\u5c04\u7684\u76ae\u4e0b\u6ce8\u5c04\u836f\u7269\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n


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\u504f\u5934\u75db\u662f\u4e00\u79cd\u5931\u80fd\u6027\u795e\u7ecf\u75be\u75c5\uff0c\u5b83\u7684\u7279\u5f81\u662f\u4e25\u91cd\u5934\u75db\u91cd\u590d\u53d1\u4f5c\uff0c\u5176\u5b83\u75c7\u72b6\u5305\u62ec\u6076\u5fc3\uff0c\u5455\u5410\uff0c\u5bf9\u5149\u58f0\u654f\u611f\uff0c\u4ee5\u53ca\u89c6\u529b\u51fa\u73b0\u53d8\u5316\u3002\u504f\u5934\u75db\u662f\u4e00\u79cd\u975e\u5e38\u5e7f\u6cdb\u7684\u795e\u7ecf\u75be\u75c5\uff0c\u5b83\u5f71\u54cd\u4e16\u754c\u4e0a10\u4ebf\u4eba\u7684\u751f\u6d3b\uff0c\u662f\u4e16\u754c\u4e0a\u7b2c6\u5927\u5931\u80fd\u6027\u75be\u75c5\u3002\u867d\u7136\u6709\u4e9b\u60a3\u8005\u6bcf\u6708\u53ea\u6709\u4e00\u6b21\u6216\u4e24\u6b21\u5934\u75db\u53d1\u4f5c\uff0c\u4f46\u662f\u6709\u8d85\u8fc7400\u4e07\u60a3\u8005\u7684\u504f\u5934\u75db\u4e3a\u6162\u6027\u504f\u5934\u75db\uff08chronic migraine\uff09\uff0c\u4ed6\u4eec\u6bcf\u6708\u81f3\u5c11\u670915\u5929\u4f1a\u5934\u75db\u53d1\u4f5c\u3002\u60a3\u8005\u6025\u9700\u80fd\u591f\u9884\u9632\u5934\u75db\u53d1\u4f5c\u7684\u521b\u65b0\u7597\u6cd5\u3002<\/span><\/p>\n


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\u793c\u6765\u516c\u53f8\u7814\u53d1\u7684Emgality\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u7684CGRP\u5355\u514b\u9686\u6297\u4f53<\/span><\/strong>\u3002\u5b83\u901a\u8fc7\u4e0eCGRP\u7ed3\u5408\uff0c\u80fd\u591f\u963b\u65adCGRP\u4e0e\u5b83\u7684\u53d7\u4f53\u76f8\u7ed3\u5408\u3002CGRP\u662f\u9884\u9632\u504f\u5934\u75db\u7684\u91cd\u8981\u9776\u70b9\uff0c\u4eca\u5e74\u5df2\u7ecf\u6709\u4e24\u6b3e\u9776\u5411CGRP\u7684\u504f\u5934\u75db\u7597\u6cd5\u83b7\u5f97FDA\u6279\u51c6\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

<\/span>\u76f8\u5173\u9605\u8bfb\uff1a<\/span><\/strong>\u91cd\u78c5\u798f\u97f3 FDA\u6279\u51c6\u9996\u4e2a\u504f\u5934\u75db\u9884\u9632\u65b0\u836f<\/span><\/strong><\/a>\uff1b<\/span><\/strong>\u4e00\u6b21\u6cbb\u7597\u53ef\u9884\u9632\u4e09\u4e2a\u6708\u504f\u5934\u75db\uff0cTeva\u65b0\u836f\u83b7FDA\u6279\u51c6<\/a><\/span><\/strong>\uff08\u56fe\u7247\u6765\u6e90\uff1a123RF\uff09<\/span><\/strong><\/p>\n


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Emgality\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u5728\u4e24\u9879\u6cbb\u7597\u53d1\u4f5c\u6027\u504f\u5934\u75db\u60a3\u8005\uff08episodic migraine\uff0c\u6bcf\u6708\u5934\u75db\u53d1\u4f5c\u5929\u6570\u4e3a4-14\u5929\uff09\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08EVOLVE-1\u548cEVOLVE-2\uff09\u548c\u4e00\u9879\u6cbb\u7597\u6162\u6027\u504f\u5934\u75db\u60a3\u8005\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08REGAIN\uff09\u4e2d\u5f97\u5230\u4e86\u8bc1\u660e\u3002<\/span><\/p>\n


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\u5728\u6cbb\u7597\u53d1\u4f5c\u6027\u504f\u5934\u75db\u60a3\u8005\u7684\u53cc\u76f2\u5b89\u6170\u5242\u5bf9\u71673\u671f\u7814\u7a76\u4e2d\uff0cEmgality\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u663e\u8457\u964d\u4f4e\u4e86\u60a3\u8005\u6bcf\u6708\u504f\u5934\u75db\u53d1\u4f5c\u7684\u5929\u6570\u3002<\/strong>\u5728EVOLVE-1\u8bd5\u9a8c\u4e2d\uff0cEmgality\u5c06\u53d1\u4f5c\u5929\u6570\u4ece\u57fa\u7ebf\u5e73\u5747\u964d\u4f4e\u4e864.7\u5929\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a2.8\u5929\uff08p<0.001\uff09\u3002\u5728EVOLVE-2\u8bd5\u9a8c\u4e2d\uff0cEmgality\u5c06\u53d1\u4f5c\u5929\u6570\u4ece\u57fa\u7ebf\u5e73\u5747\u964d\u4f4e\u4e864.3\u5929\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a2.3\u5929\uff08p<0.001\uff09\u3002<\/span><\/p>\n


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\u5728\u6cbb\u7597\u6162\u6027\u504f\u5934\u75db\u60a3\u8005<\/strong>\u7684\u53cc\u76f2\u5b89\u6170\u5242\u5bf9\u71673\u671f\u8bd5\u9a8c\u4e2d\uff0cEmgality\u5c06\u504f\u5934\u75db\u53d1\u4f5c\u5929\u6570\u5e73\u5747\u964d\u4f4e\u4e864.8\u5929\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a2.7\u5929\uff08 p<0.001\uff09\u3002<\/strong><\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

<\/span>\u25b2<\/span>\u793c\u6765\u516c\u53f8\u751f\u7269\u533b\u836f\u603b\u88c1Christi Shaw\u5973\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1a\u793c\u6765\u516c\u53f8\u5b98\u7f51\uff09<\/span><\/strong><\/p>\n


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\u201c\u867d\u7136\u504f\u5934\u75db\u5bf9\u60a3\u8005\u7684\u751f\u6d3b\u6709\u7740\u7834\u574f\u6027\u7684\u5f71\u54cd\uff0c\u4f46\u662f\u53ea\u6709\u5927\u7ea610%\u7684\u60a3\u8005\u76ee\u524d\u4f7f\u7528\u9884\u9632\u6027\u7597\u6cd5\uff0c\u201d\u793c\u6765\u516c\u53f8\u751f\u7269\u533b\u836f\u603b\u88c1Christi Shaw\u5973\u58eb\u8bf4\uff1a\u201c\u793c\u6765\u8ba4\u8bc6\u5230\u8fd9\u4e00\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u7684\u4e25\u91cd\u6027\uff0c\u5e76\u4e14\u5728\u8fc7\u53bb\u768420\u591a\u5e74\u91cc\u4e0d\u61c8\u52aa\u529b\u5f00\u53d1\u9884\u9632\u504f\u5934\u75db\u7684\u521b\u65b0\u6cbb\u7597\u9009\u62e9\u3002\u57fa\u4e8eFDA\u7684\u6279\u51c6\uff0c\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u80fd\u591f\u4e3a\u60a3\u8005\u63d0\u4f9b\u8fd9\u4e00\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] Lilly’s Emgality\u2122 (<\/span>galcanezumab<\/span>–<\/span>gnlm<\/span>) Receives U.S. FDA Approval for the Preventive Treatment of <\/span>Migraine<\/span> in Adults. Retrieved September 28, 2018, from https:\/\/www.prnewswire.com\/news-releases\/lillys-emgality-galcanezumab-gnlm-receives-us-fda-approval-for-the-preventive-treatment-of-migraine-in-adults-300720720.html<\/span><\/p>\n

[2] <\/span>Migraine<\/span>. Retrieved September 28, 2018, from https:\/\/migraineresearchfoundation.org\/about-migraine\/migraine-facts\/<\/span><\/p>\n


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\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span>
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\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u8fd1\u65e5\uff0c\u793c\u6765\u516c\u53f8\uff08Eli Lilly\uff09\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u6279\u51c6\u8be5\u516c\u53f8\u7684Emgality\uff08gal […]<\/p>\n","protected":false},"author":1,"featured_media":54953,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/54952"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=54952"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/54952\/revisions"}],"predecessor-version":[{"id":54957,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/54952\/revisions\/54957"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/54953"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=54952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=54952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=54952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}