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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

Blueprint Medicines\u4eca\u65e5\u5728\u56fd\u9645\u80ba\u764c\u7814\u7a76\u534f\u4f1a\u4e3e\u529e\u7684\u4e16\u754c\u80ba\u764c\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86\u5176\u5728\u7814\u7279\u5f02\u6027RET\u53d7\u4f53\u6291\u5236\u5242BLU-667\u4e0eosimertinib<\/strong>\uff08<\/span>\u963f<\/span>\u65af\u5229\u5eb7\u7684Tagrisso\uff09\u8054\u7528\uff0c\u6cbb\u7597\u643a\u5e26EGFR<\/em>\u57fa\u56e0\u7a81\u53d8\u7684\u96be\u6cbb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u4e24\u9879\u4e34\u5e8a\u6982\u5ff5\u9a8c\u8bc1\u8bd5\u9a8c\u7684\u79ef\u6781\u7ed3\u679c\u3002\u8be5\u8bd5\u9a8c\u7ed3\u679c\u540c\u65f6\u4e5f\u5728\u300aCancer Discovery\u300b\u4e0a\u83b7\u5f97\u53d1\u8868\u3002\u5728\u4e24\u9879\u8bd5\u9a8c\u4e2d\uff0c\u8be5<\/span>\u7ec4\u5408\u7597\u6cd5\u514b\u670d\u4e86\u4ee5\u5f80\u5728\u6807\u51c6\u7597\u6cd5\u4e2d\u4ea7\u751f\u7684\u7531\u4e8eRET<\/em>\u878d\u5408\u800c\u5f15\u8d77\u7684\u96be\u6cbb\u6027\uff0c\u5e76\u4f7f\u80bf\u7624\u7ec6\u80de\u663e\u8457\u51cf\u5c11\u3002<\/strong><\/p>\n


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RET<\/span><\/em>\u878d\u5408\u548c\u7a81\u53d8\u662f\u4ea7\u751f\u591a\u79cd\u764c\u75c7\u7684\u5173\u952e\u539f\u56e0\uff0c\u5176\u4e2d\u5305\u62ecNSCLC\u4e0e\u7532\u72b6\u817a\u9ad3\u6837\u764c\uff08MTC\uff09\u3002NSCLC\u60a3\u8005\u4e2d\u53d1\u751fRET<\/em>\u878d\u5408\u7684\u4eba\u6570\u7ea6\u4e3a1-2%\uff0c\u800c\u5728MTC\u60a3\u8005\u4e2d\u643a\u5e26RET<\/em>\u57fa\u56e0\u7a81\u53d8\u7684\u9ad8\u8fbe60%\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u7ed3\u76f4\u80a0\u764c\u3001\u4e73\u817a\u764c\u3001\u80f0\u817a\u764c\u7b49\u5176\u4ed6\u764c\u75c7\u4e5f\u6709\u8f83\u4f4e\u6982\u7387\u7684RET<\/em>\u878d\u5408\u53d1\u751f\u3002\u643a\u5e26EGFR<\/em>\u57fa\u56e0\u7a81\u53d8\u7684\u96be\u6cbb\u6027NSCLC\u60a3\u8005\u4e5f\u53ef\u80fd\u53d1\u751fRET<\/em>\u878d\u5408\u3002\u76ee\u524d\u5e76\u6ca1\u6709\u4efb\u4f55\u83b7\u6279\u7597\u6cd5\u53ef\u4ee5\u9009\u62e9\u6027\u9776\u5411RET\u6cbb\u7597\u764c\u75c7\uff0c\u4f46\u51e0\u6b3e\u5df2\u83b7\u5f97\u6279\u51c6\u7684\u591a\u86cb\u767d\u6fc0\u9176\u6291\u5236\u5242\uff08MKIs\uff09\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7686\u5bf9RET\u505a\u51fa\u8fc7\u8bc4\u4f30\u3002\u7136\u800c\uff0c\u8fd9\u51e0\u6b3eMKIs\u867d\u7136\u80fd\u591f\u6291\u5236RET\u7684\u6d3b\u6027\uff0c\u4f46\u540c\u65f6\u53ef\u80fd\u56e0\u4e3a\u8131\u9776\u6548\u5e94\u800c\u4ea7\u751f\u6bd2\u526f\u4f5c\u7528\uff0c\u800c\u4e14\u5bf9RET\u6d3b\u6027\u7684\u6291\u5236\u7a0b\u5ea6\u6709\u9650\u3002\u56e0\u6b64\uff0c\u60a3\u8005\u4eec\u6025\u9700\u4e00\u6b3e\u53ef\u4ee5\u9776\u5411RET<\/em>\u7a81\u53d8\u548c\u8010\u836f\u7a81\u53d8\u7684\u7cbe\u51c6\u7597\u6cd5\u5e2e\u52a9\u4ed6\u4eec\u5e26\u6765\u6301\u7eed\u5b89\u5168\u7684\u7597\u6548\u3002<\/span><\/p>\n


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BLU-667\u662fBlueprint Medicines\u5728\u7814\u7684\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u5f3a\u529bRET\u7279\u5f02\u6027\u6291\u5236\u5242\uff0c\u4e13\u95e8\u9776\u5411\u81f4\u764c\u7684RET<\/em>\u878d\u5408\u548c\u7a81\u53d8\u3002<\/span><\/strong>\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0cBLU-667\u663e\u793a\u51fa\u4e86\u9488\u5bf9\u591a\u79cd\u5e38\u89c1\u7684RET<\/em>\u878d\u5408\u3001\u7a81\u53d8\u4ee5\u53ca\u8010\u836f\u7a81\u53d8\u7684\u6301\u7eed\u4e9a\u6469\u5c14\uff08sub-nanomolar\uff09\u6c34\u5e73\u53cd\u5e94\u3002\u4e0e\u591a\u4e2a\u5df2\u83b7\u6279\u7684MKIs\u76f8\u6bd4\uff0cBLU-667\u5bf9RET\u7684\u9009\u62e9\u6027\u660e\u663e\u5927\u5e45\u63d0\u9ad8\uff0c\u5bf9\u6bd4VEGFR-2\u66f4\u662f\u63d0\u9ad8\u4e8680\u591a\u500d\u3002\u901a\u8fc7\u6291\u52361\u7ea7\u548c2\u7ea7\u7a81\u53d8\u578b\uff0cBLU-667\u6709\u53ef\u80fd\u514b\u670d\u5e76\u9884\u9632\u4e34\u5e8a\u8010\u836f\u7a81\u53d8\u3002\u8fd9\u5c06\u4f7fBLUE-667\u6709\u671b\u83b7\u5f97\u9488\u5bf9\u591a\u79cdRET<\/em>\u7a81\u53d8\u7684\u6301\u7eed\u4e34\u5e8a\u79ef\u6781\u53cd\u5e94\u4ee5\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/span><\/p>\n


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\u9664\u6b64\u4e4b\u5916\uff0c\u8be5\u836f\u9488\u5bf9\u643a\u5e26RET<\/em>\u53d8\u5f02\u7684NSCLC\u3001MTC\u53ca\u5176\u4ed6\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u5168\u7403\u8303\u56f41\u671f\u4e34\u5e8a\u8bd5\u9a8cARROW\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u8bc4\u4f30\u3002Blueprint Medicines\u5df2\u4e8e\u4eca\u5e744\u6708\u5728\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff092018\u5e74\u5e74\u4f1a\u4e0a\u5ba3\u5e03\u4e86ARROW\u7684\u79ef\u6781\u7ed3\u679c\u3002\u8be5\u8bd5\u9a8c\u5305\u542b19\u540dNSCLC\u60a3\u8005\uff0c29\u540dMTC\u60a3\u8005\u53ca5\u540d\u5176\u5b83\u5b9e\u4f53\u7624\u60a3\u8005\u3002\u8fd953\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u5242\u91cf\u9012\u589e\u7684BLU-667\u6cbb\u7597\uff0c\u5176\u4e2d27\u4eba\u5728\u6b64\u4e4b\u524d\u63a5\u53d7\u8fc7MKIs\u6cbb\u7597\uff0c\u53e6\u670918\u4eba\u63a5\u53d7\u8fc7\u514d\u75ab\u7597\u6cd5\u6cbb\u7597\u3002\u5b9e\u9a8c\u7ed3\u679c\u8868\u793a\uff0c84%\u643a\u5e26RET<\/em>\u53d8\u5f02\u5b9e\u4f53\u7624\u4e14\u75c5\u7076\u53ef\u4ee5\u88ab\u68c0\u6d4b\u7684\u60a3\u8005\u7684\u80bf\u7624\u6709\u6240\u7f29\u5c0f\uff0c\u4e14BLU-667\u7684\u8010\u836f\u6027\u826f\u597d\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

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\u6b64\u6b21\u516c\u5e03\u7684\u7ec4\u5408\u7597\u6cd5\u7684\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c\u4e24\u540d\u53c2\u4e0e\u8bd5\u9a8c\u7684\u643a\u5e26EGFR<\/em>\u57fa\u56e0\u7a81\u53d8\u7684\u91cd\u5ea6NSCLC\u60a3\u8005\u5728\u63a5\u53d7\u7ec4\u5408\u7597\u6cd58\u5468\u540e\uff0c\u5747\u83b7\u5f97\u4e86\u90e8\u5206\u7f13\u89e3\uff08PR\uff09<\/strong>\u3002\u53c2\u4e0e\u8bd5\u9a8c\u7684\u4e24\u4f4d\u91cd\u5ea6\u60a3\u8005\u90fd\u66fe\u63a5\u53d7\u8fc7\u524d\u671f\u6cbb\u7597\uff0c\u5e76\u7531\u4e8eRET\u878d\u5408\u57fa\u56e0\u5bf9\u6807\u51c6\u6cbb\u7597\u4ea7\u751f\u4e86\u96be\u6cbb\u6027\u3002<\/span>\u636e\u5b9e\u4f53\u7624\u7597\u6548\u8bc4\u4ef7\u6807\u51c6\uff08RECIST\uff091.1\u7248\u8bc4\u4f30\uff0c\u4e24\u540d\u60a3\u8005\u7684\u80bf\u7624\u5404\u51cf\u5c11\u4e8678%<\/strong>\uff0c\u4e14\u7ec4\u5408\u7597\u6cd5\u7684\u8010\u836f\u6027\u826f\u597d\u3002<\/span><\/p>\n


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\u201cBLU-667\u4e0eosimertinib\u8fd9\u4e24\u79cd\u9ad8\u5ea6\u9009\u62e9\u6027\u836f\u7269\u7684\u7ec4\u5408\u5f88\u6709\u53ef\u80fd\u5c06\u6210\u4e3a\u6cbb\u7597\u643a\u5e26EGFR<\/em>\u57fa\u56e0\u7a81\u53d8\u7684\u96be\u6cbb\u6027NSCLC\u7684\u65b0\u4e00\u4ee3\u7597\u6cd5\uff0c\u201d\u9ebb\u7701\u603b\u533b\u9662\u764c\u75c7\u4e2d\u5fc3\u533b\u7597\u80bf\u7624\u5b66\u4e13\u5bb6\u3001\u54c8\u4f5b\u533b\u5b66\u9662\u526f\u6559\u6388\u517c\u8bd5\u9a8c\u62a5\u544a\u8d44\u6df1\u4f5c\u8005Lecia V. Sequist\u535a\u58eb\u8bf4\uff1a\u201c\u53c2\u4e0e\u8bd5\u9a8c\u7684\u4e24\u4f4d\u91cd\u5ea6\u60a3\u8005\u90fd\u66fe\u63a5\u53d7\u8fc7\u524d\u671f\u6cbb\u7597\uff0c\u5e76\u7531\u4e8eRET<\/em>\u878d\u5408\u5bf9\u6807\u51c6\u6cbb\u7597\u4ea7\u751f\u4e86\u96be\u6cbb\u6027\u3002\u5728\u8fd9\u6b21\u8bd5\u9a8c\u4e2d\uff0c\u4e24\u4f4d\u60a3\u8005\u5728\u63a5\u53d7\u7ec4\u5408\u7597\u6cd58\u5468\u540e\u90fd\u663e\u793a\u51fa\u4e86\u660e\u663e\u7684\u79ef\u6781\u6cbb\u7597\u53cd\u5e94\uff0c\u8fd9\u610f\u5473\u7740BLU-667\u4e0eosimertinib\u7684\u7ec4\u5408\u7597\u6cd5\u5177\u6709\u6781\u5927\u7684\u6f5c\u529b\uff0c\u5e76\u5c06\u652f\u6301\u6211\u4eec\u5728\u4ee5\u540e\u7684\u8bd5\u9a8c\u4e2d\u6269\u5927\u60a3\u8005\u7684\u9009\u62e9\u8303\u56f4\u3002\u201d<\/span><\/p>\n


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\u6211\u4eec\u795d\u8d3a\u8fd9\u4e00\u7ec4\u5408\u7597\u6cd5\u6b64\u6b21\u83b7\u5f97\u7684\u4e34\u5e8a\u8bd5\u9a8c\u79ef\u6781\u7ed3\u679c\uff0c\u5e76\u671f\u5f85\u8fd9\u4e00\u7a81\u7834\u6027\u7597\u6cd5\u53ef\u4ee5\u65e9\u65e5\u83b7\u5f97\u5b8c\u5584\uff0c\u4e0e\u60a3\u8005\u4eec\u89c1\u9762\u3002<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] Blueprint Medicines Announces Proof-of-Concept Data Showing Combination of BLU-667 and Osimertinib Overcame Treatment Resistance in Two Patients with EGFR-Mutant, Non-Small Cell Lung Cancer and an Acquired RET Fusion. Retrieved September 26, 2018, from https:\/\/www.prnewswire.com\/news-releases\/blueprint-medicines-announces-proof-of-concept-data-showing-combination-of-blu-667-and-osimertinib-overcame-treatment-resistance-in-two-patients-with-egfr-mutant-non-small-cell-lung-cancer-and-an-acquired-ret-fusion-300718953.html<\/span><\/p>\n

[2] RET\u7279\u5f02\u6027\u6291\u5236\u5242\u4e34\u5e8a\u8bd5\u9a8c\u6548\u679c\u79ef\u6781. Retrieved September 26, 2018, from https:\/\/mp.weixin.qq.com\/s\/HFXN8iDv8NJcr2cWfU2QwQ<\/span><\/p>\n


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