{"id":55028,"date":"2018-09-27T01:00:00","date_gmt":"2018-09-30T02:01:00","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e9%80%9f%e9%80%92-%e6%8c%81%e4%b9%85%e6%b2%bb%e7%96%97%e8%82%ba%e7%99%8c%ef%bc%8cloxo%e6%9b%b4%e6%96%b0ret%e6%8a%91%e5%88%b6%e5%89%82%e6%9c%80%e6%96%b0%e6%95%b0%e6%8d%ae\/"},"modified":"2018-09-30T10:01:02","modified_gmt":"2018-09-30T02:01:02","slug":"%e9%80%9f%e9%80%92-%e6%8c%81%e4%b9%85%e6%b2%bb%e7%96%97%e8%82%ba%e7%99%8c%ef%bc%8cloxo%e6%9b%b4%e6%96%b0ret%e6%8a%91%e5%88%b6%e5%89%82%e6%9c%80%e6%96%b0%e6%95%b0%e6%8d%ae","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/55028\/","title":{"rendered":"\u901f\u9012 | \u6301\u4e45\u6cbb\u7597\u80ba\u764c\uff0cLoxo\u66f4\u65b0RET\u6291\u5236\u5242\u6700\u65b0\u6570\u636e"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/p>\n


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\u65e5\u524d\uff0cLoxo Oncology\u516c\u53f8\u57282018\u5e74\u7b2c19\u5c4a\u4e16\u754c\u80ba\u764c\u5927\u4f1a\u4e0a\uff0c\u5ba3\u5e03\u4e86\u8be5\u516c\u53f8\u7684\u5728\u7814\u836f\u7269LOXO-292\uff0c\u5728\u6cbb\u7597RET<\/em>\u878d\u5408\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u5168\u7403\u60271\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6700\u65b0\u4e2d\u671f\u7ed3\u679c\u3002\u8bd5\u9a8c\u7ed3\u679c\u63d0\u4f9b\u4e86LOXO-292\u8868\u73b0\u51fa\u6301\u4e45\u6d3b\u6027\u7684\u521d\u6b65\u8bc1\u636e\u3002<\/strong><\/span><\/p>\n

\"\u901f\u9012<\/p>\n

\u5728\u7f16\u7801RET\u86cb\u767d\u6fc0\u9176\u7684\u57fa\u56e0\u4e0a\u51fa\u73b0\u7684\u53d8\u5f02\u5305\u62ec\u878d\u5408\u548c\u6fc0\u6d3b\u6027\u70b9\u7a81\u53d8\uff0c\u8fd9\u4f1a\u5bfc\u81f4RET\u4fe1\u53f7\u901a\u8def\u8fc7\u5ea6\u6fc0\u6d3b\u548c\u65e0\u6cd5\u63a7\u5236\u7684\u7ec6\u80de\u589e\u957f\u3002RET<\/em>\u878d\u5408\u5728\u5927\u7ea62%\u7684NSCLC\u4e2d\u51fa\u73b0\uff0c\u800c\u6fc0\u6d3b\u6027RET<\/em>\u70b9\u7a81\u53d8\u5728\u5927\u7ea660%\u7684\u7532\u72b6\u817a\u9ad3\u6837\u764c\uff08MTC\uff09\u4e2d\u51fa\u73b0\u3002\u643a\u5e26RET<\/em>\u878d\u5408\u6216RET<\/em>\u70b9\u7a81\u53d8\u7684\u80bf\u7624\u4e3b\u8981\u4f9d\u9760\u8fd9\u4e00\u6fc0\u6d3b\u7684\u86cb\u767d\u6fc0\u9176\u6765\u652f\u6301\u4ed6\u4eec\u7684\u589e\u6b96\u548c\u751f\u5b58\uff0c\u56e0\u6b64\u4ed6\u4eec\u5bf9\u9776\u5411RET\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5242\u975e\u5e38\u654f\u611f\u3002<\/span><\/p>\n


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Loxo\u516c\u53f8\u7814\u53d1\u7684LOXO-292\u662f\u4e00\u79cd\u53e3\u670d\uff0c\u7279\u5f02\u6027RET\u6291\u5236\u5242\u3002\u5b83\u4e0d\u4f46\u80fd\u591f\u6291\u5236\u5929\u7136RET\u4fe1\u53f7\u901a\u8def\uff0c\u800c\u4e14\u53ef\u4ee5\u6291\u5236\u80bf\u7624\u53ef\u80fd\u4ea7\u751f\u7684\u6297\u6027\u673a\u5236\u3002\u800c\u8fd9\u4e9b\u6297\u6027\u673a\u5236\u662f\u9650\u5236\u5176\u5b83\u7597\u6cd5\u7597\u6548\u7684\u91cd\u8981\u539f\u56e0\u3002LOXO-292\u5df2\u7ecf\u83b7\u5f97FDA\u6388\u4e88\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u3002<\/strong><\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

\u25b2\u80bf\u7624\u4e2dRET<\/em>\u57fa\u56e0\u53d8\u5f02\u7684\u4e24\u79cd\u4e3b\u8981\u65b9\u5f0f\uff08\u56fe\u7247\u6765\u6e90\uff1aLoxo Oncology\u516c\u53f8\u5b98\u7f51\uff09<\/span><\/strong><\/p>\n


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\u5728\u540d\u4e3aLIBRETTO-001\u7684\u5f00\u653e\u6807\u7b7e1\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u643a\u5e26RET<\/em>\u878d\u5408\u7684NSCLC\u60a3\u8005\uff0cRET<\/em>\u70b9\u7a81\u53d8\u7684MTC\u60a3\u8005\u548c\u5176\u5b83RET\u6d3b\u6027\u4e0a\u5347\u7684\u764c\u75c7\u60a3\u8005\u63a5\u53d7\u4e86LOXO-292\u7684\u6cbb\u7597\u3002\u8fd9\u4e9b\u60a3\u8005\u90fd\u5df2\u7ecf\u63a5\u53d7\u8fc7\u591a\u79cd\u524d\u671f\u7cfb\u7edf\u6027\u7597\u6cd5\u300239%\u7684\u60a3\u8005\u63a5\u53d7\u8fc7\u94c2\u57fa\u5316\u7597\u548cPD-1\u6216PD-L1\u6291\u5236\u5242\u7597\u6cd5\u3002<\/span><\/p>\n


<\/p>\n

\u6700\u65b0\u7684\u4e2d\u671f\u6570\u636e\u5206\u6790\u8868\u660e\uff0c\u572838\u540d\u643a\u5e26RET<\/em>\u878d\u5408\u7684NSCLC\u60a3\u8005\u4e2d\uff0c26\u540d\u60a3\u8005\u51fa\u73b0\u5ba2\u89c2\u7f13\u89e3<\/strong>\uff08\u4f9d\u636eRECIST 1.1\uff09\u3002\u603b\u7f13\u89e3\u7387\u4e3a68%\uff0826\/38\uff09\uff0895% CI\uff1a51%-83%\uff09\u3002\u572826\u540d\u51fa\u73b0\u7f13\u89e3\u7684\u60a3\u8005\u4e2d\uff0c96%\uff0825\/26\uff09\u7684\u60a3\u8005\u4ecd\u7136\u5728\u63a5\u53d7\u6cbb\u7597\uff0c92%\uff0824\/26\uff09\u7684\u60a3\u8005\u4ecd\u5904\u4e8e\u7f13\u89e3\u671f\u3002\u4ecd\u5728\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u7684\u4e2d\u4f4d\u968f\u8bbf\u671f\u4e3a9.5\u4e2a\u6708\u3002\u7f13\u89e3\u671f\u6700\u957f\u7684\u4e00\u4f4d\u60a3\u8005\u5df2\u7ecf\u63a5\u53d7\u6cbb\u7597\u8d85\u8fc714\u4e2a\u6708<\/strong>\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

\u25b2LOXO-292\u90e8\u5206\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff08\u56fe\u7247\u6765\u6e90\uff1aLoxo Oncology\u516c\u53f8\u5b98\u7f51\uff09<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u201c\u6211\u5f88\u9ad8\u5174\u80fd\u591f\u4e0e\u80ba\u764c\u4e16\u754c\u5927\u4f1a\u7684\u4e0e\u4f1a\u8005\u5206\u4eabLOXO-292\u6cbb\u7597RET<\/em>\u878d\u5408\u9633\u6027\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\uff0c\u201d\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684\u533b\u5b66\u6559\u6388\u517c\u4e39\u5a1c-\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u6240\uff08Dana-Farber Cancer Institute\uff09\u80f8\u90e8\u80bf\u7624\u5b66\u5bb6Geoffrey R. Oxnard\u535a\u58eb\u8bf4\uff1a\u201c\u4eca\u5929\u7684\u6570\u636e\u4e3aLOXO-292\u80fd\u591f\u5728\u63a5\u53d7\u8fc7\u591a\u6b21\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u6301\u4e45\u7684\u7597\u6548\u63d0\u4f9b\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u8bc1\u636e\u3002\u201d<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] Loxo Oncology Announces LOXO-292 Durability Update in Patients with RET Fusion-Positive Non-Small Cell Lung Cancer from LIBRETTO-001 at the IASLC 19th World Conference on Lung CancerRetrieved September 26, 2018, from https:\/\/ir.loxooncology.com\/press-releases\/2368923-Loxo-oncology-announces-loxo-292-durability-update-in-patients-with-ret-fusion-positive-non-small-cell-lung-cancer-from-libretto-001-at-the-iaslc-19th-world-conference-on-lung-cancer<\/span><\/p>\n

[2] Clinical Activity of LOXO-292, a Highly Selective RET Inhibitor, in Patients with RET Fusion+ Non-Small Cell Lung Cancer, An Update from ASCO 2018. Retrieved September 26, 2018, from https:\/\/ir.loxooncology.com\/docs\/events\/WCLC_2018-LOXO292.PDF<\/span><\/p>\n


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\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span>
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