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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

PD-L1\u662f\u5168\u7403\u764c\u75c7\u7814\u7a76\u7684\u660e\u661f\u9776\u70b9\uff0c\u5b83\u5728\u8c03\u8282\u514d\u75ab\u7cfb\u7edf\u5bf9\u764c\u75c7\u7684\u653b\u51fb\u4e2d\u8d77\u5230\u5173\u952e\u4f5c\u7528\u3002PD-L1\u88ab\u79f0\u4e3a\u514d\u75ab\u68c0\u67e5\u70b9\u5206\u5b50\uff0c\u5b83\u53ef\u4e0e\u5bfc\u81f4\u81ea\u4f53\u514d\u75ab\u53cd\u5e94\u7684\u708e\u75c7\u6027T\u7ec6\u80de\u4e2d\u7684PD-1\u53d7\u4f53\u7ed3\u5408\uff0c\u4ece\u800c\u6291\u5236T\u7ec6\u80de\u7684\u6d3b\u6027\u3002\u4f46\u662f\u5982\u679c\u6211\u4eec\u53cd\u5176\u9053\u800c\u884c\u4e4b\uff1a\u4e0d\u662f\u901a\u8fc7\u6291\u5236PD-L1\uff0c\u4f7f\u5b83\u89e3\u653e\u514d\u75ab\u7cfb\u7edf\u5bf9\u764c\u7ec6\u80de\u7684\u8bc6\u522b\u548c\u653b\u51fb\uff0c\u800c\u662f\u901a\u8fc7\u63d0\u9ad8PD-L1\u7684\u6c34\u5e73\uff0c\u6765\u6291\u5236\u514d\u75ab\u7cfb\u7edf\uff0c\u538b\u5236T\u7ec6\u80de\u7684\u81ea\u4f53\u514d\u75ab\u53cd\u5e94\uff0c<\/strong>\u907f\u514d\u5176\u5bf9\u5065\u5eb7\u7ec4\u7ec7\u7684\u653b\u51fb\uff0c<\/strong>\u4f1a\u6709\u4ec0\u4e48\u4f5c\u7528\u5462\uff1f<\/span>
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\"\u524d\u6cbf<\/p>\n

\u25b2\u9488\u5bf91\u578b\u7cd6\u5c3f\u75c5\u7684\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599 [2]\uff09<\/span><\/strong>
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\u6ce2\u58eb\u987f\u513f\u7ae5\u533b\u9662\u80be\u75c5\u79d1\u7684Paolo Fiorina\u535a\u58eb\u9886\u5bfc\u7684\u7814\u7a76\u5c0f\u7ec4\u9996\u5148\u901a\u8fc7\u5206\u6790\u9020\u8840\u5e72\u7ec6\u80de\u548c\u7956\u7ec6\u80de\uff08HSPC\uff09\u8f6c\u5f55\u7ec4\u56fe\u8c31\uff0c\u53d1\u73b01\u578b\u7cd6\u5c3f\u75c5\u7684\u975e\u80a5\u80d6\u578b\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u6a21\u578b\uff08NOD\uff09\u7684PD-L1\u7684\u8868\u8fbe\u6c34\u5e73\u4e0d\u8db3\u3002<\/span><\/p>\n


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\u7814\u7a76\u8005\u4eec\u6700\u540e\u5c1d\u8bd5\u901a\u8fc7\u77eb\u6b63\u8fd9\u79cd\u7f3a\u9677\uff0c\u800c\u4e0d\u662f\u4e00\u822c\u7684\u514d\u75ab\u6291\u5236\u65b9\u6cd5\u6765\u6cbb\u75971\u578b\u7cd6\u5c3f\u75c5\u3002\u5b9e\u9a8c\u8bc1\u660e\uff0c\u77eb\u6b63\u8fc7\u7684HSPC\u7ec6\u80de\u53ef\u4ee5\u5728\u4f53\u5916\u6291\u5236\u81ea\u8eab\u514d\u75ab\u5e94\u7b54\uff0c\u5728\u65b0\u53d1\u9ad8\u8840\u7cd6\u7684NOD\u5c0f\u9f20\u4f53\u5185\u9006\u8f6c\u7cd6\u5c3f\u75c5\uff0c\u5e76\u4e14\u5bcc\u96c6\u4e8e\u9ad8\u8840\u7cd6NOD\u5c0f\u9f20\u7684\u80f0\u817a\u3002<\/strong>\u51e0\u4e4e\u6240\u6709\u5c0f\u9f20\u90fd\u5728\u77ed\u671f\u5185\u6cbb\u6108\u4e86\u7cd6\u5c3f\u75c5\uff0c\u5176\u4e2d\u4e09\u5206\u4e4b\u4e00\u5728\u5176\u4e00\u751f\u4e2d\u7ef4\u6301\u6b63\u5e38\u7684\u8840\u7cd6\u6c34\u5e73\u3002\u65e0\u8bba\u662f\u901a\u8fc7\u57fa\u56e0\u6cbb\u7597\uff08\u65e0\u5bb3\u75c5\u6bd2\u8f7d\u4f53\uff09\u8fd8\u662f\u7528\u5c0f\u5206\u5b50\u9884\u5904\u7406\u523a\u6fc0HSPC\u4e2dPD-L1\u7684\u4ea7\u751f\uff0c\u90fd\u80fd\u591f\u8d77\u5230\u7c7b\u4f3c\u7684\u6548\u679c\u3002<\/span><\/p>\n


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Paolo Fiorina\u535a\u58eb\u8bf4\uff1a\u201c\u8840\u6db2\u5e72\u7ec6\u80de\u5177\u6709\u514d\u75ab\u8c03\u8282\u80fd\u529b\uff0c\u4f46\u4f3c\u4e4e\u5728\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u548c\u4eba\u7c7b\u60a3\u8005\u4e2d\uff0c\u8fd9\u4e9b\u80fd\u529b\u53d7\u635f\u3002\u6211\u4eec\u53d1\u73b0\u5728\u7cd6\u5c3f\u75c5\u4e2d\uff0c\u8840\u6db2\u5e72\u7ec6\u80de\u6709\u7f3a\u9677\uff0c\u4fc3\u8fdb\u708e\u75c7\u5e76\u53ef\u80fd\u5bfc\u81f4\u75be\u75c5\u7684\u53d1\u4f5c\u3002\u5f53\u4f60\u6ce8\u5c04\u8fd9\u4e9b\uff08\u77eb\u6b63\u8fc7\u7684\uff09\u7ec6\u80de\u65f6\uff0c\u771f\u6b63\u91cd\u5851\u4e86\u514d\u75ab\u7cfb\u7edf\u3002\u201d<\/span><\/p>\n


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\u57fa\u4e8e\u8fd9\u4e9b\u6210\u529f\u7684\u52a8\u7269\u5b9e\u9a8c\uff0c\u4e00\u5bb6\u65b0\u7684\u751f\u7269\u6280\u672f\u516c\u53f8Altheia Science\u4e8e\u8fd1\u65e5\u6210\u7acb\u3002\u8be5\u516c\u53f8\u5c06\u57282.5-3\u5e74\u5185\u5c06\u8fd9\u4e00\u6280\u672f\u8fd0\u7528\u4e8e\u4eba\u4f53\u3002\u8fd9\u5bb6\u516c\u53f8\u7531\u4f4d\u4e8e\u610f\u5927\u5229\u7c73\u5170\u7684Aurora-TT\u6280\u672f\u8f6c\u8ba9\u96c6\u56e2\u6210\u7acb\uff0c\u5e76\u5728\u9996\u8f6e\u878d\u8d441100\u4e07\u7f8e\u5143\u3002<\/span><\/p>\n


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Altheia Science\u7684\u76ee\u6807\u5c06\u4e0d\u4ec5\u9650\u4e8e\u7cd6\u5c3f\u75c5\uff0c\u591a\u53d1\u6027\u786c\u5316\u75c7\uff08MS\uff09\u662f\u516c\u53f8\u53e6\u4e00\u4e2a\u65e9\u671f\u76ee\u6807\u3002\u5176\u5b83\u81ea\u4f53\u514d\u75ab\u75be\u75c5\uff0c\u5982\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\uff08RA\uff09\u7684\u7814\u7a76\u5c06\u5728\u665a\u4e9b\u65f6\u5019\u5c55\u5f00\u3002<\/span><\/p>\n


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[1]. An autoimmune upstart turns PD-L1 around to blaze a new approach to diabetes, multiple sclerosis. Retrieved September 25, 2018, from https:\/\/endpts.com\/an-autoimmune-upstart-turns-pd-l1-around-to-blaze-a-new-approach-to-diabetes-multiple-sclerosis\/<\/span><\/p>\n

[2]. Cell-based therapy for type 1 diabetes?. Retrieved September 25, 2018, from https:\/\/www.sciencedaily.com\/releases\/2017\/11\/171115144126.htm<\/span><\/p>\n

[3]. Fiorina, et al., (2017). PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes. Science Translational Medicine, https:\/\/doi.org\/10.1126\/scitranslmed.aam7543<\/span><\/p>\n

[4]. \u610f\u5916\u4e4b\u559c\uff01\u7ed3\u6838\u75ab\u82d7\u7adf\u80fd\u6cbb\u7597\u7cd6\u5c3f\u75c5\uff0c\u6548\u679c\u53ef\u957f\u8fbe8\u5e74. Retrieved September 25, 2018, from https:\/\/mp.weixin.qq.com\/s\/fGNK5yh4ifWEqmYoJUJ-0A<\/span><\/p>\n


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