{"id":55065,"date":"2018-09-26T01:00:00","date_gmt":"2018-09-30T02:01:26","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e9%80%9f%e9%80%92-%e9%a6%96%e6%ac%be%ef%bc%81imfinzi%e6%98%be%e8%91%97%e5%bb%b6%e9%95%bf%e8%82%ba%e7%99%8c%e6%82%a3%e8%80%85%e7%94%9f%e5%ad%98%e6%9c%9f%ef%bc%8c%e6%ad%bb%e4%ba%a1%e9%a3%8e%e9%99%a9\/"},"modified":"2018-09-30T10:01:28","modified_gmt":"2018-09-30T02:01:28","slug":"%e9%80%9f%e9%80%92-%e9%a6%96%e6%ac%be%ef%bc%81imfinzi%e6%98%be%e8%91%97%e5%bb%b6%e9%95%bf%e8%82%ba%e7%99%8c%e6%82%a3%e8%80%85%e7%94%9f%e5%ad%98%e6%9c%9f%ef%bc%8c%e6%ad%bb%e4%ba%a1%e9%a3%8e%e9%99%a9","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/55065\/","title":{"rendered":"\u901f\u9012 | \u9996\u6b3e\uff01Imfinzi\u663e\u8457\u5ef6\u957f\u80ba\u764c\u60a3\u8005\u751f\u5b58\u671f\uff0c\u6b7b\u4ea1\u98ce\u9669\u4e0b\u964d1\/3"},"content":{"rendered":"
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\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n

\u4eca\u65e5\uff0c\u4e1a\u5185\u4f20\u6765\u4e00\u6761\u91cd\u78c5\u65b0\u95fb\u3002\u963f\u65af\u5229\u5eb7\u4e0eMedImmune\u5ba3\u5e03\uff0c\u5176\u514d\u75ab\u7597\u6cd5Imfinzi\uff08durvalumab\uff09\u5728\u4e00\u9879\u9488\u5bf9\u80ba\u764c\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u663e\u8457\u5ef6\u957f\u4e86\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8fd9\u4e5f\u662f\u9488\u5bf9\u4e0d\u53ef\u5207\u9664\u7684III\u671f\u80ba\u764c\uff0c\u5f70\u663e\u51fa\u663e\u8457\u603b\u751f\u5b58\u671f\u76ca\u5904\u7684\u9996\u6b3e\u514d\u75ab\u7597\u6cd5\u3002<\/strong>
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\"\u901f\u9012<\/p>\n


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\u6211\u4eec\u77e5\u9053\uff0c\u80ba\u764c\u662f\u4e00\u7c7b\u5f71\u54cd\u5e7f\u6cdb\u7684\u75be\u75c5\u3002\u4e00\u65e6\u80ba\u764c\u8fdb\u5165\u665a\u671f\uff0c\u80fd\u591f\u5bf9\u5176\u8fdb\u884c\u6cbb\u7597\u7684\u7597\u6cd5\u5c31\u5f88\u6709\u9650\u3002\u5728\u6240\u6709\u7684\u80ba\u764c\u4e2d\uff0cIII\u671f\uff08\u5c40\u90e8\u665a\u671f\uff09\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5927\u7ea6\u5360\u4e86\u4e09\u5206\u4e4b\u4e00\uff0c\u6bcf\u5e74\u5728\u51e0\u4e2a\u80ba\u764c\u5927\u56fd\u91cc\u5f71\u54cd\u4e86\u8d85\u8fc710\u4e07\u540d\u60a3\u8005\u3002\u5bf9\u4e8e\u8fd9\u4e9b\u60a3\u8005\u6765\u8bf4\uff0cIII\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5f80\u5f80\u65e0\u6cd5\u901a\u8fc7\u624b\u672f\u5207\u9664\uff0c\u56e0\u6b64\u53ea\u80fd\u901a\u8fc7\u5316\u7597\/\u653e\u7597\u8fdb\u884c\u63a7\u5236\u3002\u5728\u521b\u65b0\u7597\u6cd5\u4e0a\uff0c\u4ed6\u4eec\u5df2\u7ecf\u7b49\u5f85\u4e86\u51e0\u5341\u5e74\u3002<\/span><\/p>\n


<\/p>\n

Imfinzi\u7684\u826f\u597d\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff0c\u6709\u671b\u6539\u53d8\u8fd9\u4e00\u73b0\u72b6\u3002\u4f5c\u4e3a\u4e00\u6b3e\u4eba\u6e90\u5316\u7684PD-L1\u5355\u514b\u9686\u6297\u4f53\uff0cImfinzi\u80fd\u6709\u6548\u6291\u5236PD-L1\u4e0ePD-1\u548cCD80\u7684\u7ed3\u5408\uff0c\u4ece\u800c\u8ba9\u80bf\u7624\u65e0\u6cd5\u51fa\u73b0\u514d\u75ab\u9003\u9038\u3002\u81ea\u95ee\u4e16\u4ee5\u6765\uff0c\u5b83\u5df2\u83b7\u6279\u6cbb\u7597\u591a\u79cd\u764c\u75c7\uff0c\u5176\u4e2d\u5305\u62ec\u4e86\u5c3f\u8def\u4e0a\u76ae\u764c\u4e0e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/span><\/p>\n


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\u5728\u4e00\u9879\u540d\u4e3aPACIFIC\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u8bc4\u4f30\u4e86Imfinzi\u5728\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u548c\u603b\u751f\u5b58\u671f\u4e0a\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u4f5c\u4e3a\u7b2c\u4e8c\u4e2a\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\uff0c\u5728\u603b\u751f\u5b58\u671f\u4e0a\uff0cImfinzi\u53d6\u5f97\u4e86\u4e0d\u4fd7\u7684\u6570\u636e\u3002\u4e0e\u6807\u51c6\u7597\u6cd5\u76f8\u6bd4\uff0c\u8fd9\u6b3e\u514d\u75ab\u7597\u6cd5\u80fd\u5c06\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e32%\uff08HR 0.68, 99.73% CI 0.47-0.997; p=0.0025\uff09<\/strong>\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8fd9\u4e9b\u6570\u636e\u5e76\u6ca1\u6709\u5c06PD-L1\u7684\u8868\u8fbe\u6c34\u5e73\u8003\u8651\u5728\u5185\uff0c\u4f53\u73b0\u4e86Imfinzi\u7684\u5e7f\u6cdb\u6f5c\u529b\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e5f\u4e8e\u4eca\u65e5\u5728\u7ebf\u53d1\u8868\u5728\u4e86\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u4e0a\u3002<\/span><\/p>\n


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\"\u901f\u9012<\/p>\n

\u25b2PACIFIC 3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u7ec8\u70b9\u6570\u636e\u6458\u8981\uff08\u56fe\u7247\u6765\u6e90\uff1a\u963f\u65af\u5229\u5eb7\u516c\u53f8\u5b98\u7f51\uff09<\/span><\/strong><\/p>\n


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\u963f\u65af\u5229\u5eb7\u8d1f\u8d23\u5168\u7403\u836f\u7269\u5f00\u53d1\u7684\u6267\u884c\u526f\u603b\u88c1\u517c\u9996\u5e2d\u533b\u5b66\u5b98Sean Bohen\u535a\u58eb\u8bf4\uff1a\u201c\u8fd9\u4e9b\u6570\u636e\u8ba9Imfinzi\u6210\u4e3a\u4e86\u4e3a\u653e\u5316\u7597\u4e4b\u540e\u4e0d\u53ef\u5207\u9664\u7684III\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5e26\u6765\u603b\u4f53\u751f\u5b58\u6536\u76ca\u7684\u9996\u6b3e\u514d\u75ab\u7597\u6cd5\u3002\u4eca\u5929\u7684\u65b0\u95fb\u4e5f\u4e3a\u8fd9\u4e9b\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u7684\u5e0c\u671b\u3002\u4ed6\u4eec\u7684\u75be\u75c5\u751f\u5b58\u7387\u51e0\u5341\u5e74\u6765\u90fd\u6ca1\u6709\u53d1\u751f\u53d8\u5316\u3002\u201d<\/span><\/p>\n


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PACIFIC\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u8981\u8d1f\u8d23\u4ebaScott J. Antonia\u535a\u58eb\u8865\u5145\u8bf4\uff1a\u201c\u8fd9\u79cd\u75be\u75c5\u76845\u5e74\u751f\u5b58\u7387\u5728\u653e\u5316\u7597\u540e\uff0c\u4e5f\u53ea\u670915%\u5de6\u53f3\u3002PACIFIC\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u7684\u663e\u8457\u751f\u5b58\u6536\u76ca\u8ba9\u6211\u4eec\u5bf9\u65b0\u7684\u6cbb\u7597\u6807\u51c6\u6709\u4e86\u4fe1\u5fc3\u3002\u201d<\/span><\/p>\n


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\u6211\u4eec\u795d\u8d3a\u8fd9\u6b3e\u65b0\u836f\u80fd\u57283\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u51fa\u5bf9\u96be\u6cbb\u80ba\u764c\u7684\u751f\u5b58\u671f\u6536\u76ca\uff0c\u4e5f\u5e0c\u671b\u5b83\u80fd\u8fdb\u4e00\u6b65\u4e3a\u60a3\u8005\u5e26\u6765\u798f\u97f3\u3002<\/span><\/p>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n

[1] <\/span>Imfinzi<\/span> is the first immunotherapy to demonstrate <\/span>significant<\/span> overall survival benefit in unresectable, Stage III lung cancer, Retrieved September 25, 2018, from https:\/\/www.astrazeneca.com\/media-centre\/press-releases\/2018\/imfinzi-is-the-first-immunotherapy-to-demonstrate-significant-overall-survival-benefit-in-unresectable-stage-iii-lung-cancer25092018.html<\/span><\/p>\n

[2] AstraZeneca spells out a major drop in the risk of death for stage 3 NSCLC patients taking Imfinzi \u2014 and why that\u2019s important, Retrieved September 25, 2018, from https:\/\/endpts.com\/astrazeneca-spells-out-a-major-drop-in-the-risk-of-death-for-stage-3-nsclc-patients-taking-imfinzi\/<\/span><\/p>\n


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\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span>
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