{"id":55283,"date":"2018-09-29T01:00:00","date_gmt":"2018-09-30T02:03:13","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/09\/30\/%e3%80%90%e6%99%ba%e7%bf%94pdl-1%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%851%e3%80%91gr1501%e6%b3%a8%e5%b0%84%e6%b6%b2%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93%e7%98%a4%e6%88%96%e6%b7%8b%e5%b7%b4\/"},"modified":"2018-09-30T10:03:13","modified_gmt":"2018-09-30T02:03:13","slug":"%e3%80%90%e6%99%ba%e7%bf%94pdl-1%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%851%e3%80%91gr1501%e6%b3%a8%e5%b0%84%e6%b6%b2%e5%9c%a8%e6%99%9a%e6%9c%9f%e5%ae%9e%e4%bd%93%e7%98%a4%e6%88%96%e6%b7%8b%e5%b7%b4","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/55283\/","title":{"rendered":"\u3010\u667a\u7fd4PDL-1\u62db\u52df\u60a3\u80051\u3011GR1501\u6ce8\u5c04\u6db2\u5728\u665a\u671f\u5b9e\u4f53\u7624\u6216\u6dcb\u5df4\u7624\u7684\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u5242\u91cf\u9012\u589e\u7684\u5b89\u5168\u6027\u53ca\u521d\u6b65\u7597\u6548\u8bc4\u4ef7\u4e34\u5e8a\u7814\u7a76"},"content":{"rendered":"
\n
<\/mpcps><\/section>\n

<\/span><\/span>
<\/p>\n

1.       <\/span><\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span><\/span><\/p>\n

GR1501<\/span>\u6ce8\u5c04\u6db2\u662f<\/span>\u91cd\u5e86\u667a\u7fd4\u91d1\u6cf0<\/span>\u7814\u53d1\u7684\u6297<\/span>PDL-1<\/span>\u5355\u514b\u9686\u6297\u4f53\uff0c\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f<\/span>\u665a\u671f\u5b9e\u4f53\u80bf\u7624\u6216\u6dcb\u5df4\u7624<\/span>\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

2.       <\/span><\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n

\u8bc4\u4ef7<\/span>GR1405<\/span>\u6ce8\u5c04\u6db2\u5728\u4e2d\u56fd\u665a\u671f\u5b9e\u4f53\u80bf\u7624\u548c\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\u7684\u6700\u5927\u8010\u53d7\u5242\u91cf\u548c\u5b89\u5168\u6027\u7279\u5f81\uff1b\u8bc4\u4ef7<\/span>GR1405<\/span>\u6ce8\u5c04\u6db2\u5728\u4e2d\u56fd\u665a\u671f\u5b9e\u4f53\u80bf\u7624\u548c\u6dcb\u5df4\u7624\u60a3\u8005\u4f53\u5185\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u4ee5\u53ca\u521d\u6b65\u7597\u6548\u3001\u514d\u75ab\u539f\u6027\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

3.       <\/span><\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u5206\u7c7b\uff1a<\/span>  <\/span>\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u5206\u671f\uff1a<\/span>  I<\/span>\u671f<\/span><\/span><\/p>\n

\u8bbe\u8ba1\u7c7b\u578b\uff1a<\/span>  <\/span>\u5355\u81c2\u8bd5\u9a8c<\/span><\/span><\/p>\n

\u968f\u673a\u5316\uff1a<\/span>      <\/span>\u975e\u968f\u673a\u5316<\/span><\/span><\/p>\n

\u76f2\u6cd5\uff1a<\/span>          <\/span>\u5f00\u653e<\/span> <\/span><\/span><\/p>\n

\u8bd5\u9a8c\u8303\u56f4\uff1a<\/span>  <\/span>\u56fd\u5185\u8bd5\u9a8c<\/span>        <\/span><\/span><\/p>\n

\u8bd5\u9a8c\u4eba\u6570\uff1a<\/span>  60~124<\/span>\u4eba<\/span><\/span><\/p>\n

 <\/span><\/p>\n

4.       <\/span><\/span>\u5165\u9009\u6807\u51c6<\/span><\/span><\/p>\n

\uff08<\/span>1<\/span>\uff09\u80bf\u7624\u60a3\u8005\uff0c\u6839\u636e<\/span>RECIST v1.1<\/span>\uff08\u5b9e\u4f53\u7624\uff09\u6216<\/span>Lugano 2014<\/span>\u6807\u51c6\uff08\u6dcb\u5df4\u7624\uff09\uff0c\u53d7\u8bd5\u8005\u81f3\u5c11\u5b58\u5728\u4e00\u4e2a\u53ef\u6d4b\u91cf\u75c5\u7076\u6216\u53ef\u8bc4\u4f30\u75c5\u7076\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>2<\/span>\uff09\u5e74\u9f84\u2265<\/span> 18<\/span>\u5468\u5c81\u4e14\u2264<\/span>75<\/span>\u5468\u5c81\uff0c\u7537\u5973\u5747\u53ef\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>3<\/span>\uff09<\/span> ECOG <\/span>\u8bc4\u5206\u2264<\/span>1<\/span>\u5206\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>4<\/span>\uff09\u80b2\u9f84\u671f\u5973\u6027\u53d7\u8bd5\u8005\u6216\u7537\u6027\u53d7\u8bd5\u8005\u53ca\u5176\u4f34\u4fa3\uff0c\u613f\u610f\u5728\u6574\u4e2a\u6cbb\u7597\u671f\u53ca\u6cbb\u7597\u671f\u540e<\/span>6<\/span>\u4e2a\u6708\u91c7\u53d6\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>5<\/span>\uff09\u5177\u6709\u5145\u5206\u7684\u5668\u5b98\u548c\u9aa8\u9ad3\u529f\u80fd\uff0c<\/span><\/span><\/p>\n

\uff08<\/span>6<\/span>\uff09\u9996\u6b21\u7ed9\u836f\u524d\u60a3\u8005\u63a5\u53d7\u4e0a\u4e00\u6b21\u6297\u80bf\u7624\u6cbb\u7597\u540e\u81f3\u5c11<\/span>4<\/span>\u5468\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>7<\/span>\uff09\u60a3\u8005\u6216\u5176\u6cd5\u5b9a\u4ee3\u7406\u4eba\u7b7e\u7f72\u4e66\u9762\u77e5\u60c5\u540c\u610f\u4e66\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

5.       <\/span><\/span>\u6392\u9664\u6807\u51c6<\/span><\/span><\/p>\n

\uff08<\/span>1<\/span>\uff09\u65e2\u5f80\u63a5\u53d7\u4efb\u4f55\u514d\u75ab\u6cbb\u7597\u836f\u7269\u671f\u95f4\u51fa\u73b0\u8fc7\u4efb\u4f55<\/span>NCI CTCAE v4.03 <\/span>\u2265<\/span>3<\/span>\u7ea7<\/span>irAE<\/span>\u8005\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>2<\/span>\uff09\u65e2\u5f80\u6216\u540c\u65f6\u60a3\u6709\u5176\u5b83\u6076\u6027\u80bf\u7624\u8005\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>3<\/span>\uff09\u6000\u5b55\u6216\u8005\u54fa\u4e73\u671f\u5973\u6027\u60a3\u8005\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>4<\/span>\uff09\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027<\/span>\/<\/span>\u7537\u6027\u8bd5\u9a8c\u671f\u95f4\u62d2\u7edd\u91c7\u7528\u907f\u5b55\u63aa\u65bd\u7684\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>5<\/span>\uff09\u4e25\u91cd\u7684\u75be\u75c5\u6216\u5e76\u53d1\u75c7\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>6<\/span>\uff09\u5165\u9009\u524d<\/span>6<\/span>\u4e2a\u6708\u5185\u6025\u6027\u5fc3\u808c\u6897\u6b7b\u3001\u4e0d\u7a33\u5b9a\u5fc3\u7ede\u75db\u3001\u4e2d\u98ce\u6216\u77ed\u6682\u6027\u8111\u7f3a\u8840\u6027\u53d1\u4f5c\u7b49\u75be\u75c5\u53f2\uff0c\u7f8e\u56fd\u7ebd\u7ea6\u5fc3\u810f\u75c5\u5b66\u4f1a\uff08<\/span>NYHA<\/span>\uff09\u5206\u7ea7\u4e3a<\/span>2<\/span>\u7ea7\u53ca\u4ee5\u4e0a\u7684\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>7<\/span>\uff09\u6709\u514d\u75ab\u7f3a\u9677\u75c5\u53f2\uff0c\u5305\u62ec\uff1a<\/span>HIV<\/span>\u9633\u6027\uff0c\u6216\u5176\u4ed6\u83b7\u5f97\u6027\u3001\u5148\u5929\u6027\u514d\u75ab\u7f3a\u9677\u75be\u75c5\uff0c\u6216\u6709\u81ea\u4f53\u5668\u5b98\u79fb\u690d\u53f2\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>8<\/span>\uff09\u9157\u9152\u8005\u548c<\/span>\/<\/span>\u6216\u836f\u7269\u6ee5\u7528\u8005\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>9<\/span>\uff09\u8fc7\u654f\u4f53\u8d28\u8005\u3001\u6216\u5bf9\u5df2\u77e5\u7814\u7a76\u836f\u7269\u6210\u5206\u8fc7\u654f\u8005\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>10<\/span>\uff09\u9996\u6b21\u7ed9\u836f\u524d<\/span>1<\/span>\u4e2a\u6708\u5185\u63a5\u53d7\u8fc7\u5176\u4ed6\u4e34\u5e8a\u8bd5\u9a8c\u836f\u7269\u6cbb\u7597\u8005\uff1b<\/span><\/span><\/p>\n

\uff08<\/span>11<\/span>\uff09\u7814\u7a76\u8005\u8ba4\u4e3a\u6709\u4e0d\u9002\u5408\u53c2\u52a0\u8bd5\u9a8c\u7684\u5176\u4ed6\u56e0\u7d20\u8005\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

6.       <\/span><\/span>\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n\n\n\n\n\n\n
\n

\u5e8f\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u673a\u6784\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u7814\u7a76\u8005 <\/span><\/p>\n<\/td>\n

\n

\u56fd\u5bb6 <\/span><\/p>\n<\/td>\n

\n

\u7701\uff08\u5dde\uff09 <\/span><\/p>\n<\/td>\n

\n

\u57ce\u5e02 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u4eba\u6c11\u89e3\u653e\u519b\u7b2c\u4e090\u4e03\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5f90\u5efa\u660e <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2 <\/span><\/p>\n<\/td>\n

\n

\u54c8\u5c14\u6ee8\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u767d\u7389\u8d24 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u9ed1\u9f99\u6c5f\u7701 <\/span><\/p>\n<\/td>\n

\n

\u54c8\u5c14\u6ee8\u5e02 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

3 <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5f90\u519c <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f <\/span><\/p>\n<\/td>\n

\n

\u676d\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n

\u672c\u8bd5\u9a8c\u4fe1\u606f\u6765\u81ea<\/span>CFDA<\/span>\u201c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u516c\u793a\u5e73\u53f0\u201d\u3002<\/span><\/span><\/p>\n

\u6b22\u8fce\u7533\u529e\u65b9\/CRO\/\u533b\u9662\u63d0\u4f9b\u80bf\u7624\u62db\u52df\u4fe1\u606f\uff0c\u53ef\u4ee5\u53d1\u90ae\u4ef6\u81f3LCSYZMXX@163.com\uff0c\u672c\u516c\u4f17\u53f7\u514d\u8d39\u63a8\u9001\u3002<\/span><\/p>\n

\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

1.       \u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb GR1501\u6ce8\u5c04\u6db2 […]<\/p>\n","protected":false},"author":1,"featured_media":55284,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/55283"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=55283"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/55283\/revisions"}],"predecessor-version":[{"id":55285,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/55283\/revisions\/55285"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/55284"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=55283"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=55283"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=55283"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}